Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Hamburg (Germany) 2011
• Research
• 

  Selected Grants

  • A novel platform to determine RABEP2 function as a therapeutic target in human ischemic stroke awarded by  American Heart Association 2022 - 2025
  • ATTRACT: Arterial flow as attractor for endothelial cell migration - a new concept in vascular malformation and stroke regeneration awarded by Fondation Leducq 2018 - 2023
  • A consortium effort to translate therapies for neurological diseases via an immune-competent organotypic platform awarded by University of North Carolina - Chapel Hill 2021 - 2023
  • Novel Targets for Stroke Intervention - Gene Discovery for Modulators of Infarction awarded by National Institutes of Health 2017 - 2022
  • Rock Inhibition as Therapy for Cerebral Cavernous Malformation awarded by University of Chicago 2016 - 2017
  • Natural genetic variation regulating infarct volume awarded by National Institutes of Health 2009 - 2014
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Reuter, Sean P., Mark H. Soonpaa, Dorothy Field, Ed Simpson, Michael Rubart-von der Lohe, Han Kyu Lee, Arthi Sridhar, et al. “Cardiac Troponin I-Interacting Kinase Affects Cardiomyocyte S-Phase Activity but Not Cardiomyocyte Proliferation.” Circulation 147, no. 2 (January 10, 2023): 142–53. https://doi.org/10.1161/CIRCULATIONAHA.122.061130.
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    • Lee, Han Kyu, Do Hoon Kwon, David L. Aylor, and Douglas A. Marchuk. “A cross-species approach using an in vivo evaluation platform in mice demonstrates that sequence variation in human RABEP2 modulates ischemic stroke outcomes.” Am J Hum Genet 109, no. 10 (October 6, 2022): 1814–27. https://doi.org/10.1016/j.ajhg.2022.09.003.
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    • Lee, Han Kyu, Sarah E. Wetzel-Strong, David L. Aylor, and Douglas A. Marchuk. “A Neuroprotective Locus Modulates Ischemic Stroke Infarction Independent of Collateral Vessel Anatomy.” Front Neurosci 15 (2021): 705160. https://doi.org/10.3389/fnins.2021.705160.
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    • Lee, Han Kyu, Samuel J. Widmayer, Min-Nung Huang, David L. Aylor, and Douglas A. Marchuk. “Novel Neuroprotective Loci Modulating Ischemic Stroke Volume in Wild-Derived Inbred Mouse Strains.” Genetics 213, no. 3 (November 2019): 1079–92. https://doi.org/10.1534/genetics.119.302555.
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    • Lee, Han Kyu, Sehwon Koh, Donald C. Lo, and Douglas A. Marchuk. “Neuronal IL-4Rα modulates neuronal apoptosis and cell viability during the acute phases of cerebral ischemia.” Febs J 285, no. 15 (August 2018): 2785–98. https://doi.org/10.1111/febs.14498.
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    • Lee, Han Kyu, Sehoon Keum, Huaxin Sheng, David S. Warner, Donald C. Lo, and Douglas A. Marchuk. “Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume.” J Clin Invest 126, no. 8 (August 1, 2016): 2827–38. https://doi.org/10.1172/JCI84491.
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    • Keum, Sehoon, Han Kyu Lee, Pei-Lun Chu, Matthew J. Kan, Min-Nung Huang, Carol J. Gallione, Michael D. Gunn, Donald C. Lo, and Douglas A. Marchuk. “Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke.” Plos Genet 9, no. 10 (2013): e1003807. https://doi.org/10.1371/journal.pgen.1003807.
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