Scholars@Duke
John Miles Harrelson

John Miles Harrelson

Professor Emeritus of Orthopaedic Surgery
Orthopaedic Surgery
harre004@mc.duke.edu
Box 3023 Med Ctr, Durham, NC 27710
1581 Hosp South - White Zone, Durham, NC 27710

Selected Publications

Leiomyosarcoma of the somatic soft tissues.

Journal Article J Surg Orthop Adv · 2012 Leiomyosarcomas of the somatic soft tissues are tumors of smooth muscle origin that occur in the extremities. These lesions are commonly high-grade tumors that carry a poor prognosis. Recommended treatment often includes wide excision and chemotherapy or r ... Full text Link to item Cite

The effect of intermittent pneumatic compression on fracture healing.

Journal Article J Orthop Trauma · July 2005 OBJECTIVES: Continuously increased venous pressure has been shown to enhance bone growth, stimulate fracture healing, and prevent bone loss, but also causes soft-tissue breakdown as a result of chronic edema. This study was designed to test the hypothesis ... Full text Link to item Cite

Treatment of osseous metastases in patients with renal cell carcinoma.

Journal Article Clin Orthop Relat Res · April 2003 The records of 99 patients treated at one institution for osseous metastases secondary to renal cell carcinoma were reviewed. Patients were followed up for at least 24 months or until death. Survival was analyzed with respect to age, gender, disease-free i ... Full text Link to item Cite

Utility of fine-needle aspiration in the diagnosis of primary osteosarcoma.

Journal Article Diagn Cytopathol · December 2002 Featured Publication Fine-needle aspiration (FNA) is a reliable, safe, and cost-effective procedure with a well-established role in the diagnosis of various solid tissue neoplasms. The role of FNA in the diagnosis of primary bone tumors, including osteosarcoma (OGS), is contro ... Full text Link to item Cite

Intramuscular myxoma: a clinicopathologic study of 17 patients.

Journal Article Clin Orthop Relat Res · October 2002 Featured Publication The office and hospital records of 17 patients treated for intramuscular myxomas between 1979 and the present were reviewed. Thirteen women and four men were diagnosed with an intramuscular myxoma at an average age of 55 years (range, 31-76 years). Each pa ... Link to item Cite

Giant-cell tumor of the appendicular skeleton.

Journal Article Clin Orthop Relat Res · July 2002 Featured Publication The common objective of all surgical procedures in the treatment of giant-cell tumor of bone is to minimize the incidence of local recurrence. The purpose of this study was to determine what, if any, patient factors, tumor characteristics, or surgical prac ... Full text Link to item Cite

Adjuvant chemotherapy for osteosarcoma may not increase survival after neoadjuvant chemotherapy and surgical resection.

Journal Article J Surg Oncol · November 2001 Featured Publication BACKGROUND AND OBJECTIVES: Osteosarcoma is a primary malignancy of bone. Current therapy includes neoadjuvant chemotherapy, surgery, and postoperative (adjuvant) chemotherapy. Prolonged treatment with chemotherapeutic agents may place patients at increased ... Full text Link to item Cite

Chondrosarcoma of bone: analysis of 108 cases and evaluation for predictors of outcome.

Journal Article Clin Orthop Relat Res · October 2001 Featured Publication Chondrosarcoma is the second most common malignant bone tumor and is relatively unresponsive to chemotherapy and radiation regimens. In addition, the clinical course of chondrosarcoma is difficult to predict. The purpose of this study was to review the aut ... Link to item Cite

Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.

Journal Article Mol Cell Biol · July 2001 The function of the epidermal growth factor receptor (EGFR) family member HER4 remains unclear because its activating ligand, heregulin, results in either proliferation or differentiation. This variable response may stem from the range of signals generated ... Full text Link to item Cite

Solitary renal cell carcinoma metastasis to the hand: the need for wide excision or amputation.

Journal Article J Hand Surg Am · January 2001 Featured Publication Metastatic renal cell carcinoma responds poorly to chemotherapy or radiation therapy and is associated with a dismal survival rate. In cases of a solitary acrometastasis, the literature supports complete resection of the lesion in an effort to prolong surv ... Full text Link to item Cite

A phase II trial testing the thermal dose parameter CEM43 degrees T90 as a predictor of response in soft tissue sarcomas treated with pre-operative thermoradiotherapy.

Journal Article Int J Hyperthermia · 2001 Featured Publication We prospectively evaluated whether delivering a thermal dose of > 10 cumulative equivalent minutes at 43 degrees C to >90% of the tumour sites monitored (CEM43 degrees T90) would produce a pathologic complete response (pCR) in > 75% of high-grade soft tiss ... Full text Link to item Cite

The clinical significance of tenascin-C splice variant expression in chondrosarcoma.

Journal Article Oncology · 2001 Featured Publication OBJECTIVES: Tenascin-C (TNC) is an oligomeric glycoprotein of the extracellular matrix that is prominently expressed in malignant tumors. The purpose of this study was: (1) to determine the in vitro TNC splicing pattern in cultured human chondrocytes and c ... Full text Link to item Cite

Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis).

Journal Article Arch Pathol Lab Med · November 2000 Featured Publication CONTEXT: Pigmented villonodular synovitis (PVNS) is a well-recognized entity that has the potential for extensive local destruction, even though it rarely metastasizes. Rare reports of malignant forms are recorded in the literature. We observed 2 patients ... Full text Link to item Cite

Granular cell tumors of the extremities.

Journal Article Clin Orthop Relat Res · November 2000 Granular cell tumors are uncommon tumors that may arise from various soft tissue and visceral sites. These lesions often are multifocal but, with rare exceptions, are benign. Much of the literature on granular cell tumors is based on case reports mostly in ... Full text Link to item Cite

Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis): A histopathologic and fluorescence in situ hybridization analysis of 2 cases with review of the literature

Journal Article Archives of Pathology and Laboratory Medicine · January 1, 2000 Context. - Pigmented villonodular synovitis (PVNS) is a well-recognized entity that has the potential for extensive local destruction, even though it rarely metastasizes. Rare reports of malignant forms are recorded in the literature. We observed 2 patient ... Full text Cite

Calcium-activated tenderization of strip loin, top sirloin, and top round steaks in diverse genotypes of cattle.

Journal Article J Anim Sci · December 1999 Featured Publication Steers of known percentage Brahman (B) and Angus (A) breeding (100% A, n = 6; F1 B x A, n = 6; and 100% B, n = 6) were used to determine the effect of calcium chloride injection on the calpain proteinase system and meat tenderness. The steers were slaughte ... Full text Link to item Cite

The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 1999 Featured Publication PURPOSE: To explore the use of a novel program of preoperative radiation and hyperthermia in the management of high-grade soft tissue sarcomas (STS). METHODS AND MATERIALS: Eligible patients were adults over 18 with Grade 2 or 3 STS, surgically resectable ... Full text Link to item Cite

Collagenase specificity in chondrosarcoma metastasis.

Journal Article Braz J Med Biol Res · July 1999 Featured Publication The treatment of some mesenchymal malignancies has made significant gains over the past few decades with the development of effective systemic therapies. In contrast, the treatment of chondrosarcoma has been limited to surgical resection, with the most sig ... Full text Link to item Cite

Juxtaphyseal aneurysmal bone cysts.

Journal Article Clin Orthop Relat Res · July 1999 Featured Publication Aneurysmal bone cysts are benign primary or secondary lesions that commonly arise in long bones and often before skeletal maturity. Little has been written about aneurysmal bone cysts that abut the physeal plate. The records of 15 patients with juxtaphysea ... Full text Link to item Cite

Synovial sarcoma of the foot and ankle.

Journal Article Clin Orthop Relat Res · July 1999 Featured Publication Synovial sarcoma of the foot and ankle frequently is misdiagnosed, which leads to delays in treatment. The clinical records of 14 patients with synovial sarcoma of the foot and ankle were reviewed. Common findings at presentation were an enlarging mass wit ... Full text Link to item Cite

Pigmented villonodular synovitis of the foot and ankle: a review of six cases.

Journal Article Foot Ankle Int · May 1999 Featured Publication Pigmented villonodular synovitis is a rare but well recognized proliferative lesion of synovial tissue. It has been most commonly described in the knee and hip, with most series reporting <5% occurrence in the foot and ankle. Six patients with pigmented vi ... Full text Link to item Cite

Ipsilateral fibular slide grafts in the management of distal fibula lesions.

Journal Article Foot Ankle Int · February 1999 Featured Publication Full text Link to item Cite

Total femoral replacement

Journal Article Operative Techniques in Orthopaedics · January 1, 1999 The development of limb salvage techniques in the operative management of malignant bone tumors has emerged as a result of effective neoadjuvant preoperative chemotherapy. Wide excision of these tumors has replaced radical excision as definitive management ... Full text Cite

Proximal humeral resection and reconstruction

Journal Article Operative Techniques in Orthopaedics · January 1, 1999 Resection of the proximal humerus may be required for control of benign, primary malignant, or metastatic neoplasms. The defect created by such a resection may spare the shoulder cuff muscles and deltoid (Malawer type IA) or remove them (Malawer type IB). ... Full text Cite

Metastatic carcinoma to skeletal muscle. A report of 15 patients.

Journal Article Clin Orthop Relat Res · October 1998 Featured Publication The records of 15 patients with metastatic carcinoma to skeletal muscle treated between 1979 and the present were reviewed. Fourteen patients were referred with a diagnosis of soft tissue sarcoma and one with suspected infection. There was a previous diagn ... Full text Link to item Cite

Association between ratio of matrix metalloproteinase-1 to tissue inhibitor of metalloproteinase-1 and local recurrence, metastasis, and survival in human chondrosarcoma.

Journal Article J Bone Joint Surg Am · January 1998 Featured Publication Chondrosarcoma, a malignant cartilage-forming mesenchymal tumor, displays a wide range of clinical behavior that can be difficult to predict with histological analysis. Matrix metalloproteinases contribute to the processes of local invasion and metastasis ... Link to item Cite

Cytologic findings in tenosynovial giant cell tumors investigated by fine-needle aspiration cytology.

Journal Article Diagn Cytopathol · April 1997 Tenosynovial giant cell tumor is a relatively common benign proliferation affecting the articular and periarticular soft tissues. Cytologic findings on smears obtained by fine-needle aspiration are rather characteristic and include a mixture of oval or pol ... Full text Link to item Cite

Prognostic markers in chondrosarcoma: evaluation of cell proliferation and of regulators of the cell cycle.

Journal Article Sarcoma · 1997 Purpose. The prognosis, treatment principles and prediction of clinical outcome of patients with chondrosarcoma currently rest on histologic grading which is somewhat ambiguous due to difficulty in pathologic interpretation of this neoplasm. Immunohistoche ... Full text Link to item Cite

Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas.

Journal Article Cancer Res · December 1, 1996 The adverse prognostic impact of tumor hypoxia has been demonstrated in human malignancy. We report the effects of radiotherapy and hyperthermia (HT) on soft tissue sarcoma oxygenation and the relationship between treatment-induced changes in oxygenation a ... Link to item Cite

Monitoring of neoadjuvant therapy response of soft-tissue and musculoskeletal sarcoma using fluorine-18-FDG PET.

Journal Article J Nucl Med · September 1996 UNLABELLED: The purpose of this study was to investigate the potential role of FDG-PET in the monitoring of neoadjuvant therapy of soft-tissue and musculoskeletal sarcomas. METHODS: Nine patients were studied. Neoadjuvant therapy consisted of either chemot ... Link to item Cite

Multifocal vascular lesions of bone: imaging characteristics.

Journal Article Skeletal Radiol · April 1996 OBJECTIVE: Multifocal vascular processes which arise in bone are a very inhomogeneous class of diseases. Four of these processes are derived from endothelial precursors, however, and share a similar radiographic spectrum. These four entities are reviewed i ... Full text Link to item Cite

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

Journal Article Cancer Res · March 1, 1996 This study was performed to explore the relationship between tumor oxygenation and treatment outcome in human soft tissue sarcoma. Twenty-two patients with nonmestastatic, high-grade, soft tissue sarcomas underwent preoperative irradiation and hyperthermia ... Link to item Cite

Fibular osteochondroma presenting as chronic ankle sprain.

Journal Article Foot Ankle Int · April 1995 A 19-year-old baseball player was referred for assessment of recurrent sprains of the right ankle. This was found to be secondary to a palsy of the common peroneal nerve that was compressed by an osteochondroma of the fibular neck. The lesion was resected ... Full text Link to item Cite

Clinical outcome after neoadjuvant thermoradiotherapy in high grade soft tissue sarcomas.

Journal Article J Surg Oncol · November 1994 In the treatment of soft tissue sarcomas, hyperthermia has been demonstrated to enhance tumor necrosis from radiation therapy. The current study reports the clinical course of patients treated with this neoadjuvant therapy regimen. Forty-four patients with ... Full text Link to item Cite

Pretreatment oxygenation profiles of human soft tissue sarcomas.

Journal Article Int J Radiat Oncol Biol Phys · October 15, 1994 PURPOSE: Tumor oxygenation is thought to influence the radiocurability of many malignancies. Advances in polarographic electrode technology have facilitated the in situ measurement of human tumor pO2. The optimal method of defining a "hypoxic" tumor is not ... Full text Link to item Cite

Melanoma of the foot.

Journal Article J Bone Joint Surg Am · June 1994 We performed a prospective study of the results of treatment of primary cutaneous melanoma of the foot in 282 patients to determine if there were any factors that could predict survival. These patients were part of a group of 1018 patients who had primary ... Full text Link to item Cite

Therapy monitoring in human and canine soft tissue sarcomas using magnetic resonance imaging and spectroscopy.

Journal Article Int J Radiat Oncol Biol Phys · January 15, 1994 PURPOSE: The goals of this study were to determine whether magnetic resonance parameters (a) can identify early during therapy those patients most likely to respond to hyperthermia and radiotherapy, (b) can provide prior to or early during therapy informat ... Full text Link to item Cite

MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas.

Journal Article Radiology · January 1994 PURPOSE: To enable prediction of tumor response to a particular treatment. MATERIALS AND METHODS: The authors studied the value of hydrogen-1 T2 and phosphorus-31 magnetic resonance (MR) spectroscopic metabolic determinations as indicators of prognosis in ... Full text Link to item Cite

The diabetic foot: Charcot arthropathy.

Journal Article Instr Course Lect · 1993 Link to item Cite

Free vascularized fibula in traumatic long bone defects and in limb salvaging following tumor resection: comparative study.

Journal Article Microsurgery · 1993 In this retrospective analysis, we present our experience with two groups of patients who had long bone defects secondary to trauma or tumor resection and who were treated with a free vascularized fibular graft for skeletal reconstruction. Both groups were ... Full text Link to item Cite

Vascularized tissue transfer for closure of irradiated wounds after soft tissue sarcoma resection.

Journal Article Ann Surg · November 1992 During the years 1985 to 1989, 82 patients were included in the soft tissue sarcoma protocol. Preoperative irradiation (50-54 Gy) was performed in all patients before tumor extirpation. Microwave hyperthermia was performed in conjunction with radiation in ... Full text Link to item Cite

Relationships among tumor temperature, treatment time, and histopathological outcome using preoperative hyperthermia with radiation in soft tissue sarcomas.

Journal Article Int J Radiat Oncol Biol Phys · 1992 The lack of an unambiguous thermal dosimetry continues to impede progress in clinical hyperthermia. In an attempt to define better this dosimetry, a model based on the cumulative minutes during which arbitrary percentages of measured tumor temperature poin ... Full text Link to item Cite

Treatment of pathologic fracture of the humerus.

Journal Article Clin Orthop Relat Res · July 1991 Twenty-one patients with 22 pathologic humeral fractures were seen between January 1977 and November 1988. All fractures were secondary to myeloma or metastatic disease. Primary bone tumors were not included. Nineteen of 22 fractures were treated with intr ... Link to item Cite

Tetracycline labeling of the femoral head following acute intracapsular fracture of the femoral neck.

Journal Article Clin Orthop Relat Res · June 1991 The purpose of this study was to assess the utility of tetracycline hydrochloride (HCl) labeling of the femoral head following acute intracapsular fracture of the femoral neck to indirectly assess femoral head viability and vascularity. A standard labeling ... Link to item Cite

Hemangiopericytoma of the sciatic nerve. Case report.

Journal Article J Neurosurg · March 1991 The authors report the case of a hemangiopericytoma arising in a sciatic nerve. It was found to be invasive within the epineurium but sparing surrounding tissues. Adequate resection required sacrifice of the nerve. Hemangiopericytomas can be added to the s ... Full text Link to item Cite

Orthotic management of diabetic neuropathic arthropathy

Journal Article Journal of Prosthetics and Orthotics · January 1, 1991 Full text Cite

Pyomyositis in a temperate climate. Presentation, diagnosis, and treatment.

Journal Article J Bone Joint Surg Am · September 1990 The cases of eighteen patients who were treated for pyomyositis between 1970 and 1988 were evaluated. The diagnosis was often delayed because other primary diagnoses were considered, including muscle strain, synovitis, thrombophlebitis, and neoplasm, and b ... Link to item Cite

Soft-tissue sarcomas: MR imaging and MR spectroscopy for prognosis and therapy monitoring. Work in progress.

Journal Article Radiology · March 1990 The authors studied the usefulness of hydrogen-1 T2 measurements and phosphorus-31 magnetic resonance (MR) spectroscopy as indicators of prognosis and monitors of response to therapy in a group of patients with soft-tissue sarcomas. All eight patients were ... Full text Link to item Cite

Multicentric malignant fibrous histiocytoma of soft tissue.

Journal Article Am J Surg Pathol · February 1990 We present an unusual case of multicentric malignant fibrous histiocytoma of soft tissue. Over the past 24 years, a 67-year-old woman developed malignant fibrous histiocytoma in four different soft-tissue sites. There were two local recurrences of one of t ... Full text Link to item Cite

Imaging of tumoral calcinosis: new observations.

Journal Article Radiology · January 1990 Five patients with tumoral calcinosis were evaluated with radiography, bone scintigraphy, computed tomography (CT), and magnetic resonance (MR) imaging. The arthropathy of calcium pyrophosphate dihydrate deposition disease was seen in two of the patients a ... Full text Link to item Cite

Magnetic resonance imaging of the femoral head after acute intracapsular fracture of the femoral neck.

Journal Article J Bone Joint Surg Am · January 1990 In fifteen patients who had a subcapital fracture of the femoral neck (twelve displaced fractures and three non-displaced fractures), magnetic resonance imaging of the femoral head was done with two-dimensional Fourier transform spin-echo technique within ... Link to item Cite

Management of the diabetic foot.

Journal Article Orthop Clin North Am · October 1989 Treatment of diabetic foot pathology requires an accurate assessment of the etiologic factors involved. Dysvascular deterioration may be amenable to vascular reconstruction. When the vascular status cannot be improved, however, amputation is preferable to ... Link to item Cite

Tumor temperature distributions predict hyperthermia effect.

Journal Article Int J Radiat Oncol Biol Phys · March 1989 Review of clinical hyperthermia (HT) trial results shows that there previously has not been a robust model relating efficacy of HT treatments to characteristics of the temperature distribution. Lack of a model has been an impediment in Phase II trials; the ... Full text Link to item Cite

Systemic doxorubicin and intraarterial cisplatin preoperative chemotherapy plus postoperative adjuvant chemotherapy in patients with osteosarcoma.

Journal Article Cancer · March 1, 1989 The role of adjuvant chemotherapy for osteosarcoma has been well defined. Recently, the use of preoperative chemotherapy has been further enhanced by the use of intraarterial cisplatin. The authors describe the use and results of systemic doxorubicin and i ... Full text Link to item Cite

Preoperative hyperthermia and radiation for soft tissue sarcomas: advantage of two vs one hyperthermia treatments per week.

Journal Article Int J Radiat Oncol Biol Phys · January 1989 As part of an ongoing Phase II trial at Duke University Medical Center (DUMC), patients with Stage IIB-IVA soft tissue sarcomas (STS) potentially amenable to wide local excision were treated with preoperative hyperthermia (HT) plus radiation therapy (RT), ... Full text Link to item Cite

Evaluation in cats of a new material for cranioplasty: a composite of plaster of Paris and hydroxylapatite.

Journal Article J Neurosurg · August 1988 The materials ordinarily used to reconstruct bone defects in the calvaria and facial bones either are difficult to shape, are partially resorbed by the body, or are likely to become infected if used near a contaminated area such as the frontal sinus. Calci ... Full text Link to item Cite

Fractures of the polyethylene bearing insert in Bateman bipolar hip prostheses.

Journal Article Clin Orthop Relat Res · March 1988 Six cases of fractures of the polyethylene bearing insert of Bateman bipolar hip prostheses were observed in three patients at four to eight years after implantation. Three fractured prostheses were salvaged by replacement with new bearing inserts. In thre ... Link to item Cite

Primary actinomycosis of an extremity: a case report and review.

Journal Article Rev Infect Dis · 1987 Primary infection of an extremity is an uncommon feature of actinomycosis and can readily be confused with actinomycetoma caused by aerobic actinomycetes such as Nocardia and Streptomyces. A case of primary actinomycosis of the leg is reported, and 35 case ... Full text Link to item Cite

Calcification of entheses associated with X-linked hypophosphatemic osteomalacia.

Journal Article N Engl J Med · July 4, 1985 We undertook a retrospective analysis of 26 patients with X-linked hypophosphatemic osteomalacia (or rickets), whose ages ranged from 1 to 62 years and who were from 11 different kindreds, to determine the prevalence and clinical characteristics of a uniqu ... Full text Link to item Cite

Healing of bone disease in X-linked hypophosphatemic rickets/osteomalacia. Induction and maintenance with phosphorus and calcitriol.

Journal Article J Clin Invest · June 1985 Although conventional therapy (pharmacologic doses of vitamin D and phosphorus supplementation) is usually successful in healing the rachitic bone lesion in patients with X-linked hypophosphatemic rickets, it does not heal the coexistent osteomalacia. Beca ... Full text Link to item Cite

Aluminum deposition at the osteoid-bone interface. An epiphenomenon of the osteomalacic state in vitamin D-deficient dogs.

Journal Article J Clin Invest · May 1985 Although aluminum excess is an apparent pathogenetic factor underlying osteomalacia in dialysis-treated patients with chronic renal failure, the mechanism by which aluminum impairs bone mineralization is unclear. However, the observation that aluminum is p ... Full text Link to item Cite

The concurrence of hypoparathyroidism provides new insights to the pathophysiology of X-linked hypophosphatemic rickets.

Journal Article J Clin Endocrinol Metab · April 1985 Controversy exists over the role that PTH and extracellular fluid calcium concentration may play in modulation of the renal phosphate transport defect in X-linked hypophosphatemic rickets. In previous studies, administration of PTH to affected subjects res ... Full text Link to item Cite

Computed tomography of axial skeletal osteoid osteomas.

Journal Article AJR Am J Roentgenol · April 1984 Five cases of axial skeletal osteoid osteomas were viewed with particular attention to the role of computed tomography (CT) as a key diagnostic tool in the evaluation of osteoid osteoma. The complex anatomy of the axial skeleton can make the diagnosis of o ... Full text Link to item Cite

Postparathyroidectomy hypocalcemia as an accurate indicator of preparathyroidectomy bone histology in the uremic patient.

Journal Article Miner Electrolyte Metab · 1984 19 chronic renal failure patients underwent iliac crest bone biopsy prior to total parathyroidectomy with autotransplantation. The preoperative serum calcium concentration did not correlate with the number of osteoclasts/mm2 present on the preparathyroidec ... Link to item Cite

Septic arthritis due to Mycoplasma hominis.

Journal Article Arthritis Rheum · August 1983 Full text Link to item Cite

Hormonal and metabolic regulation of human chondrosarcoma in vitro.

Journal Article Cancer Res · February 1983 Prostaglandin A1 has a profound inhibitory effect on uridine incorporation into RNA of normal cartilage whereas N6-monobutyryladenosine 3',5'-cyclic monophosphate is either stimulatory or without an effect. Sera from intact and growth hormone-treated hypop ... Link to item Cite

Afferent sensory feedback for lower extremity prosthesis.

Journal Article Clin Orthop Relat Res · September 1982 Electrical stimulation has been applied to sciatic nerves of patients to achieve sensory feedback after lower limb amputation for periods of up to six years. Patients used the sensory feedback device daily. Pain, infection and electrode displacement have n ... Link to item Cite

A quantitative histomorphometric comparison of 40 micron thick Paragon sections with 5 micron thick Goldner sections in the study of undecalcified bone.

Journal Article Calcif Tissue Int · May 1982 The value of quantitative histomorphometric analysis of undecalcified stained sections of bone is widely recognized. Five micron thick sections have been regarded as essential to carry out this analysis, but their production requires expensive equipment. O ... Full text Link to item Cite

Osteomalacia after parathyroidectomy in patients with uremia.

Journal Article Ann Intern Med · January 1982 Five patients on maintenance dialysis had symptoms of osteomalacia, proven by biopsy, after parathyroidectomy. In all five patients clinical and radiographic manifestations of secondary hyperparathyroidism were present before surgery, and in two patients p ... Full text Link to item Cite

Osteomalacia in chronic renal failure: a syndrome previously reported only with maintenance dialysis.

Journal Article Am J Nephrol · 1982 Osteomalacia without marked elevations of parathyroid hormone (PTH) has been described in maintenance dialysis patients. The proposed etiology has centered upon the transfer of an environmental agent (aluminum) from the dialysis water system. The present r ... Full text Link to item Cite

CT detection of intraosseous gas: a new sign of osteomyelitis.

Journal Article AJR Am J Roentgenol · October 1981 In three patients the diagnosis of osteomyelitis was made when computed tomography (CT) demonstrated gas within the medullary cavity of the involved bone. The diagnosis was clinically unsuspected in two of the patients before the CT examination, and none s ... Full text Link to item Cite

A quantitative histologic study of avian osteopetrotic bone demonstrating normal osteoclast numbers and increased osteoblastic activity.

Journal Article Lab Invest · February 1981 Hyperostotic diseases caused by increased osteoblastic activity are poorly understood partially because a suitable animal model is not available for their study. In contrast, a hyperostotic disorder caused by defective osteoclasts (mammalian osteopetrosis) ... Link to item Cite

Evaluation of a role for 1,25-dihydroxyvitamin D3 in the pathogenesis and treatment of X-linked hypophosphatemic rickets and osteomalacia.

Journal Article J Clin Invest · November 1980 Although a defect in renal transport of phosphate seems well established as the primary abnormality underlying the pathogenesis of X-linked hypophosphatemic rickets and osteomalacia, several observations indicate that renal phosphate wasting and hypophosph ... Full text Link to item Cite

Bone-grafting in total hip replacement for acetabular protrusion.

Journal Article J Bone Joint Surg Am · October 1980 Since 1971 we have used homologous and autogenous bone grafts to reinforce the medial acetabular wall when doing a total hip replacement in patients with painful protrusio acetabuli. Thirty-two patients have been followed for a minimum of two years, the lo ... Link to item Cite

The development of the upper end of the femur, with special reference to its internal architecture.

Journal Article Radiology · October 1980 The development of the upper end of the femur was determined from radiographic analysis of the hips in 191 children and a small series of cadaver specimens from young subjects, with special attention directed to the internal architecture. At birth, linearl ... Full text Link to item Cite

Hypophosphatemic osteomalacia: association with prostatic carcinoma.

Journal Article Ann Intern Med · August 1980 Hypophosphatemic osteomalacia that remits after resection of a coexisting tumor has been described in 35 patients. Because the associated neoplasms have been of mesenchymal origin, it has been inferred that this tumor-induced osteomalacia syndrome is uniqu ... Full text Link to item Cite

Newer knowledge of vitamin D and its metabolites in health and disease.

Journal Article Clin Orthop Relat Res · 1979 Renewed interest in vitamin D, over the past several years, has resulted in increased knowledge of (1) the metabolic pathways which result in production of an active metabolite, (2) the role of its various metabolities at target tissues, and (3) its intera ... Link to item Cite

Hand metastasis from melanoma: a case study.

Journal Article Clin Orthop Relat Res · October 1978 Metastases to the hand are rare. Most frequently they result from carcinomas of the lung, breast or kidney. This is a case report of a rare peripheral metastatic lesion in a 24-year-old man with melanoma. There are no previously reported hand metastases fr ... Link to item Cite

Skeletal metastases of melanoma.

Journal Article J Bone Joint Surg Am · July 1978 Sixteen hundred and seventy-seven melanoma patients were treated at Duke University Medical Center from 1956 to 1976. Osseous metastases were more common than previously reported and occurred in 116 patients (6.9 per cent), most often in the axial skeleton ... Link to item Cite

Hypertrophy of the flexor carpi ulnaris as a cause of ulnar nerve compression in the distal part of the forearm. Case report

Journal Article Journal of Bone and Joint Surgery Series A · January 1, 1975 Compression of the ulnar nerve at the wrist,, near or in Guyon's canal, has been reported frequently, and many causes have been identified, but occupationally induced hypertrophy of the flexor carpi ulnaris muscle is not among them. This cause of ulnar ner ... Full text Cite

Meniscectomy in osteoarthritis.

Journal Article Clin Orthop Relat Res · June 1974 Link to item Cite