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Todd B Harshbarger

Assistant Professor in Radiology
Brain Imaging and Analysis Ctr, Box 3918, Durham, NC 27710
40 Duke Medicine Circle, Davison 414, Box 3918, Durham, NC 27710

Selected Publications

Effects of Lifelong Musicianship on White Matter Integrity and Cognitive Brain Reserve.

Journal Article Brain Sci · January 6, 2021 There is a significant body of research that has identified specific, high-end cognitive demand activities and lifestyles that may play a role in building cognitive brain reserve, including volume changes in gray matter and white matter, increased structur ... Full text Link to item Cite

Longitudinal changes in symptom-based female and male LUTS clusters.

Journal Article Neurourol Urodyn · January 2020 AIMS: Lower urinary tract symptoms (LUTS) are diverse in type and variable in severity. We examined symptom change within the Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort study identified clusters over time a ... Full text Link to item Cite

Neural activation for actual and imagined movement following unilateral hand transplantation: a case study.

Journal Article Neurocase · December 2019 Transplantation of a donor hand has been successful as a surgical treatment following amputation, but little is known regarding the brain mechanisms contributing to the recovery of motor function. We report functional magnetic resonance imaging (fMRI) find ... Full text Open Access Link to item Cite

Are three-day voiding diaries feasible and reliable? Results from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) cohort.

Journal Article Neurourol Urodyn · November 2019 AIMS: The aims of this study were to assess the completeness of voiding diaries in a research context and to correlate diary data with patient-reported questionnaires. METHODS: Men and women enrolled in the Symptoms of Lower Urinary Tract Dysfunction Resea ... Full text Link to item Cite

The Distribution of Post-Void Residual Volumes in People Seeking Care in the Symptoms of Lower Urinary Tract Dysfunction Network Observational Cohort Study With Comparison to Asymptomatic Populations.

Journal Article Urology · August 2019 OBJECTIVE: To describe the distribution of post-void residual (PVR) volumes across patients with and without lower urinary tract symptoms (LUTS) and examine relationships between self-reported voiding symptoms, storage symptoms, and PVR. METHODS: PVR and d ... Full text Link to item Cite

Longitudinal Changes in Regional Cerebral Perfusion and Cognition After Cardiac Operation.

Journal Article Ann Thorac Surg · January 2019 BACKGROUND: Cardiac operation has been associated with increased risk of postoperative cognitive decline, as well as dementia risk in the general population. Few studies, however, have examined the impact of coronary revascularization or valve replacement ... Full text Open Access Link to item Cite

Relationship Between Central Obesity, General Obesity, Overactive Bladder Syndrome and Urinary Incontinence Among Male and Female Patients Seeking Care for Their Lower Urinary Tract Symptoms.

Journal Article Urology · January 2019 OBJECTIVES: To describe the relationship between metabolic factors and lower urinary tract symptoms, overactive bladder syndrome (OAB) and urinary incontinence (UI). METHODS: Adult male and female patients who presented to a clinician from the symptoms of ... Full text Link to item Cite

Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults.

Journal Article Hum Brain Mapp · February 2018 OBJECTIVES: Older adults often display postoperative cognitive decline (POCD) after surgery, yet it is unclear to what extent functional connectivity (FC) alterations may underlie these deficits. We examined for postoperative voxel-wise FC changes in respo ... Full text Open Access Link to item Cite

Resting-State Functional Connectivity and Cognition After Major Cardiac Surgery in Older Adults without Preoperative Cognitive Impairment: Preliminary Findings.

Journal Article J Am Geriatr Soc · January 2017 OBJECTIVES: To look for changes in intrinsic functional brain connectivity associated with postoperative changes in cognition, a common complication in seniors undergoing major surgery, using resting-state functional magnetic resonance imaging. DESIGN: Obj ... Full text Open Access Link to item Cite

Changes in Brain Resting-state Functional Connectivity Associated with Peripheral Nerve Block: A Pilot Study.

Journal Article Anesthesiology · August 2016 BACKGROUND: Limited information exists on the effects of temporary functional deafferentation (TFD) on brain activity after peripheral nerve block (PNB) in healthy humans. Increasingly, resting-state functional connectivity (RSFC) is being used to study br ... Full text Open Access Link to item Cite

Symptoms of Lower Urinary Tract Dysfunction Research Network.

Journal Article J Urol · July 2016 PURPOSE: To address gaps in understanding and treating lower urinary tract symptoms, the NIDDK created the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). The goals of LURN are to work collaboratively to 1) identify and explain the imp ... Full text Link to item Cite

Multisensory conflict modulates the spread of visual attention across a multisensory object.

Journal Article Neuroimage · August 15, 2010 Spatial attention to a visual stimulus that occurs synchronously with a task-irrelevant sound from a different location can lead to increased activity not only in the visual cortex, but also the auditory cortex, apparently reflecting the object-related spr ... Full text Link to item Cite

Differentiating sensitivity of post-stimulus undershoot under diffusion weighting: implication of vascular and neuronal hierarchy.

Journal Article PLoS One · August 13, 2008 The widely used blood oxygenation level dependent (BOLD) signal during brain activation, as measured in typical fMRI methods, is composed of several distinct phases, the last of which, and perhaps the least understood, is the post-stimulus undershoot. Alth ... Full text Open Access Link to item Cite

Endogenous functional CBV contrast revealed by diffusion weighting.

Journal Article NMR Biomed · December 2006 Functional MRI (fMRI) based on the blood oxygenation level dependent (BOLD) contrast often suffers from a lack of specificity because of the vascular spread of oxygenation changes. It is suggested from the optical imaging and animal fMRI literature that ce ... Full text Link to item Cite

B factor dependence of the temporal characteristics of brain activation using dynamic apparent diffusion coefficient contrast.

Journal Article Magn Reson Med · December 2004 Functional MRI studies to date have been generally performed using the blood oxygenation level dependent (BOLD) contrast mechanism. Recently, it has been proposed that dynamic change in the apparent diffusion coefficient (ADC), measured using intravoxel in ... Full text Link to item Cite

Functional activation using apparent diffusion coefficient-dependent contrast allows better spatial localization to the neuronal activity: evidence using diffusion tensor imaging and fiber tracking.

Journal Article Neuroimage · October 2003 Recent studies suggested that functional activation using apparent diffusion coefficient (ADC) contrast can be used to detect synchronized functional MRI (fMRI) signal changes during brain activation. Such changes may reflect better spatial localization to ... Full text Link to item Cite

Iterative reconstruction of single-shot spiral MRI with off resonance.

Journal Article IEEE Trans Med Imaging · March 1999 A variety of applications and research directions in magnetic resonance imaging which require fast scan times have recently become popular. In order to satisfy many of the requirements of these applications, snapshot imaging methods, which acquire an entir ... Full text Link to item Cite

A method to measure arbitrary k-space trajectories for rapid MR imaging.

Journal Article Magn Reson Med · September 1997 A method to measure arbitrary k-space trajectories was developed to compensate for nonideal gradient performance during rapid magnetic resonance (MR) imaging with actively or nonactively shielded gradients at a magnetic field strength of 4.1 T. Accurate MR ... Full text Link to item Cite