Scholars@Duke
Harvey Gorden Moore III

Harvey Gorden Moore III

Associate Professor of Surgery
Surgical Oncology

Selected Publications

A Multidimensional Bioinformatic Platform for the Study of Human Response to Surgery.

Journal Article Ann Surg · June 1, 2022 OBJECTIVE: To design and establish a prospective biospecimen repository that integrates multi-omics assays with clinical data to study mechanisms of controlled injury and healing. BACKGROUND: Elective surgery is an opportunity to understand both the system ... Full text Link to item Cite

Disparity of Colon Cancer Outcomes in Rural America: Making the Case to Travel the Extra Mile.

Journal Article J Gastrointest Surg · November 2019 OBJECTIVES: Rural patients experience disparities in cancer care compared to urban patients. We hypothesized that rural patients with colon cancer who traveled to high-volume centers for treatment have similar survival compared to urban patients who also t ... Full text Link to item Cite

Long-term Clinical Outcomes of Nonoperative Management With Chemoradiotherapy for Locally Advanced Rectal Cancer in the Veterans Health Administration.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2019 PURPOSE: Standard therapy for locally advanced rectal cancer includes neoadjuvant chemoradiation and surgery. Complete response (CR) rates after chemoradiation can be as high as 29%, suggesting that nonoperative management (NOM) may be reasonable with appr ... Full text Link to item Cite

Neoadjuvant long-course chemoradiation remains strongly favored over short-course radiotherapy by radiation oncologists in the United States.

Journal Article Cancer · April 15, 2017 BACKGROUND: Short-course radiotherapy (SC-RT) and long-course chemoradiotherapy (LC-CRT) are accepted neoadjuvant treatments of rectal cancer. In the current study, the authors surveyed US radiation oncologists to assess practice patterns and attitudes reg ... Full text Link to item Cite

HIV Infection Is Associated With Poor Outcomes for Patients With Anal Cancer in the Highly Active Antiretroviral Therapy Era.

Journal Article Dis Colon Rectum · December 2015 BACKGROUND: HIV status may affect outcomes after definitive chemoradiotherapy for anal cancer. OBJECTIVE: Here, we report a large series in the highly active antiretroviral therapy era comparing outcomes between HIV-positive and HIV-negative patients with ... Full text Link to item Cite

Validation of the English translation of the low anterior resection syndrome score.

Journal Article Colorectal Dis · October 2015 AIM: Many patients having anterior resection for rectal cancer suffer from severe long-term bowel dysfunction, known as low anterior resection syndrome (LARS). The LARS score was developed in Denmark, and Swedish, Spanish and German versions have been vali ... Full text Link to item Cite

Predictors of complete response and disease recurrence following chemoradiation for rectal cancer

Journal Article Frontiers in Oncology · January 1, 2015 Objective: Approximately 10-40% of rectal patients have a complete response (CR) to neoadjuvant chemoradiation (CRT), and these patients have improved survival. Thus, non-operative management ("watch-and-wait" approach) may be an option for select patients ... Full text Cite

Patients with colorectal and renal cell carcinoma diagnoses appear to be at risk for additional malignancies

Journal Article Clinical Colorectal Cancer · January 1, 2013 Background: Small studies have demonstrated that patients who have both colorectal and renal cell carcinoma may be at increased risk for the development of additional malignancies. A possible genetic basis has been suggested. Our study describes the clinic ... Full text Cite

The safety of a pancreaticoduodenectomy in patients older than 80 years: risk vs. benefits.

Journal Article HPB (Oxford) · September 2012 BACKGROUND: A pancreaticoduodenectomy (PD) offers the only chance of a cure for pancreatic cancer and can be performed with low mortality and morbidity. However, little is known about outcomes of a PD in octogenarians. METHODS: Differences in two groups of ... Full text Link to item Cite

Effect of intra-operative fluid volume on peri-operative outcomes after pancreaticoduodenectomy for pancreatic adenocarcinoma.

Journal Article J Surg Oncol · January 2012 BACKGROUND: Excess use of intravenous fluid can increase post-operative complications. We examined the influence of intra-operative crystalloid (IOC) administration on complications following pancreaticodudenectomy (PD) for pancreatic adenocarcinoma. METHO ... Full text Link to item Cite

Colorectal cancer: what should patients and families be told to lower the risk of colorectal cancer?

Journal Article Surg Oncol Clin N Am · October 2010 Colorectal cancer (CRC) is the second most common cause of cancer-related death in the United States. CRC, however, is potentially preventable, and several strategies may be employed to decrease the incidence of and mortality from CRC. Understanding of ind ... Full text Link to item Cite

Three synchronous primary carcinomas in a patient with HNPCC associated with a novel germline mutation in MLH1: Case report.

Journal Article World J Surg Oncol · December 8, 2009 BACKGROUND: MLH1 is one of six known genes responsible for DNA mismatch repair (MMR), whose inactivation leads to HNPCC. It is important to develop genotype-phenotype correlations for HNPCC, as is being done for other hereditary cancer syndromes, in order ... Full text Link to item Cite

Patterns of recurrence of colorectal cancer.

Conference J Surg Oncol · January 1, 2008 Full text Link to item Cite

Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management.

Journal Article Ann Surg · April 2007 OBJECTIVE: This study summarizes our initial experience with prospective, single-amplicon (mutation-specific) A636P testing in Ashkenazi Jewish patients at risk for Hereditary Nonpolyposis Colorectal Cancer (HNPCC). SUMMARY BACKGROUND DATA: We previously d ... Full text Link to item Cite

A prospective pathologic analysis using whole-mount sections of rectal cancer following preoperative combined modality therapy: implications for sphincter preservation.

Journal Article Ann Surg · January 2007 OBJECTIVE: The aims of this study were to use a comprehensive whole-mount pathologic analysis to characterize microscopic patterns of residual disease, as well as circumferential and distal resection margins, in rectal cancer treated with preoperative CMT; ... Full text Link to item Cite

Effect of Sulindac on Gene Expression in Rectal MucosaLimited Project Grant #071

Journal Article Seminars in Colon and Rectal Surgery · December 1, 2006 Full text Cite

Submucosal resection of giant gastric lipoma.

Journal Article J Surg Oncol · July 1, 2006 Full text Link to item Cite

Familial adenomatous polyposis and mental retardation caused by a de novo chromosomal deletion at 5q15-q22: report of a case.

Journal Article Dis Colon Rectum · November 2005 Familial adenomatous polyposis, caused by mutations in the adenomatous polyposis coli gene located at chromosome 5q21, is an autosomal dominant syndrome characterized by polyposis of the colon and rectum and nearly 100 percent progression to colorectal can ... Full text Link to item Cite

Clinical examination following preoperative chemoradiation for rectal cancer is not a reliable surrogate end point.

Journal Article J Clin Oncol · May 20, 2005 PURPOSE: Clinical assessment of rectal cancer response to preoperative combined-modality therapy (CMT) using digital rectal examination (DRE) has been proposed as a means of assessing efficacy of therapy. However, because the accuracy of this approach has ... Full text Link to item Cite

The authors reply

Journal Article Diseases of the Colon and Rectum · January 1, 2005 Full text Cite

Expression of p27 in residual rectal cancer after preoperative chemoradiation predicts long-term outcome.

Journal Article Ann Surg Oncol · November 2004 BACKGROUND: Compared with surgery alone, preoperative radiotherapy and 5-fluorouracil-based chemotherapy (combined-modality therapy; CMT) improves outcomes in patients with locally advanced rectal cancer. Although numerous studies have focused on identifyi ... Full text Link to item Cite

Colorectal cancer pelvic recurrences: determinants of resectability.

Journal Article Dis Colon Rectum · October 2004 PURPOSE: This study was designed to identify preoperative and intraoperative features of locally recurrent colorectal cancer that predict R0 resection in patients scheduled for attempted complete resection followed by intraoperative radiation therapy. METH ... Full text Link to item Cite

Sequential preoperative fluorodeoxyglucose-positron emission tomography assessment of response to preoperative chemoradiation: a means for determining longterm outcomes of rectal cancer.

Journal Article J Am Coll Surg · July 2004 BACKGROUND: We have previously demonstrated that fluorodeoxyglucose-positron emission tomography (FDG-PET) can assess extent of pathologic response of primary rectal cancer to preoperative chemoradiation. Our goal was to determine the prognostic significan ... Full text Link to item Cite

Rate of pathologic complete response with increased interval between preoperative combined modality therapy and rectal cancer resection.

Journal Article Dis Colon Rectum · March 2004 INTRODUCTION: Recent data suggest a favorable prognosis for rectal cancer patients with a pathologic complete response to preoperative combined modality therapy. Prolongation of the interval between preoperative combined modality therapy and surgery (RT-su ... Full text Link to item Cite

Residual mesorectal lymph node involvement following neoadjuvant combined-modality therapy: rationale for radical resection?

Journal Article Ann Surg Oncol · February 2004 BACKGROUND: In order to evaluate the impact of preoperative radiation and chemotherapy (combined modality therapy, or CMT) on primary rectal cancer and mesorectal lymph nodes (MLNs), middle and lower third rectal cancers were resected with total mesorectal ... Full text Link to item Cite

Patterns of morphological alteration in residual rectal carcinoma following preoperative chemoradiation

Journal Article American Journal of Surgical Pathology · February 1, 2004 Cite

Patterns of morphologic alteration in residual rectal carcinoma following preoperative chemoradiation and their association with long-term outcome.

Journal Article Am J Surg Pathol · February 2004 Preoperative radiation (RT) and chemotherapy improve outcome in patients with locally advanced rectal adenocarcinoma and, therefore, have been used increasingly in patient management. The histopathologic alterations in postirradiated rectal adenocarcinoma ... Full text Link to item Cite

A636P testing in Ashkenazi Jews

Journal Article Familial Cancer · 2004 Full text Cite

Prognostic significance of depth of gross or microscopic perirectal fat invasion in T3 N0 M0 rectal cancers following sharp mesorectal excision and no adjuvant therapy.

Journal Article Int J Colorectal Dis · November 2003 BACKGROUND AND AIMS: Although the standard of care for T3 and/or N1-2 rectal cancers includes adjuvant chemoradiation, it is unclear whether T3 N0 patients with limited microscopic perirectal fat invasion warrant further therapy. Our aim was to determine t ... Full text Link to item Cite

A case-controlled study of 18-fluorodeoxyglucose positron emission tomography in the detection of pelvic recurrence in previously irradiated rectal cancer patients.

Journal Article J Am Coll Surg · July 2003 BACKGROUND: Although effective at detecting locally recurrent colorectal cancer, the accuracy of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) for detecting rectal cancer recurrence in an irradiated pelvis has not been systematicall ... Full text Link to item Cite

Multimodality management of locally advanced rectal cancer.

Journal Article Am Surg · July 2003 Despite the routine use of adjuvant chemoradiation for curatively resected stage II and III rectal cancer a significant percentage of patients ultimately fail locally and/or distally; this underscores the need for continued improvement in the efficacy of c ... Link to item Cite

Adequacy of 1-cm distal margin after restorative rectal cancer resection with sharp mesorectal excision and preoperative combined-modality therapy.

Journal Article Ann Surg Oncol · 2003 BACKGROUND: Preoperative combined-modality therapy (CMT) for rectal cancer allows a sphincter-sparing procedure in some individuals who would otherwise require an abdominoperineal resection. To further define the subset of rectal cancer patients suitable f ... Full text Link to item Cite

Anal neoplasms.

Journal Article Surg Clin North Am · December 2002 A common theme in most anal neoplasms appears to be a delay in diagnosis due to confusion with more common, benign conditions. Thus, the clinician must maintain a high index of suspicion when evaluating lesions of the anal canal and margin. The use of prim ... Full text Link to item Cite

Adenocarcinoma of the anal canal

Journal Article Clinics in Colon and Rectal Surgery · November 1, 2002 Anal adenocarcinoma is a rare tumor, comprising only 3 to 19% of all tumors arising in the anal canal. The site of origin of anal adenocarcinoma is controversial, but likely candidates include the anal glands and chronic fistula-in-ano. Signs and symptoms ... Full text Cite

Local therapy for rectal cancer.

Journal Article Surg Clin North Am · October 2002 Local procedures for carefully selected distal rectal cancer offer significant advantages such as sphincter preservation and avoidance of radical surgery. However, since preoperative selection criteria including current imaging modalities are unable to def ... Full text Link to item Cite

Attenuated familial adenomatous polyposis: an evolving and poorly understood entity.

Journal Article Dis Colon Rectum · January 2002 PURPOSE: Familial adenomatous polyposis is a well-described, autosomal dominant, inherited syndrome characterized by diffuse polyposis of the colon and rectum as well as various upper gastrointestinal and extraintestinal manifestations. A subset of patient ... Full text Link to item Cite

Total mesorectal excision in rectal cancer resection

Journal Article Clinics in Colon and Rectal Surgery · January 1, 2002 Despite the routine use of adjuvant chemoradiation for Stages II-III curatively resected rectal cancer, a significant percentage of patients ultimately fail locally and/or distally. Recognition of the importance of lateral, or circumferential, margins of r ... Full text Cite