Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Research Fellowship, Transplantation Branch, National Institutes of Health 1999 - 2001
  • Surgical Research Fellowship, Surgery, Loma Linda University 1995 - 1997
  • Postdoctoral Research Scientist, Surgery, Columbia University 1991 - 1992
  • PostdoctoralResearch Fellow, Surgery, Columbia University 1988 - 1990
  • Cardiothoracic Fellowship, Surgery, Capital Institute of Medicine (China) 1986 - 1988
  • Resident, Surgery, Capital Institute of Medicine (China) 1983 - 1986
  • M.D., Hebei Medical College (China) 1983
• 

  Duke Appointment History

  • Instructor, Temporary in the Department of Surgery, Surgery, Surgical Sciences, Surgery 2014
• Research
• 

  Selected Grants

  • Phase 2 Study of Belatacept, Alemtuzumab, and Sirolimus in Renal Transplantation awarded by Food and Drug Administration 2015 - 2020
  • T Cell Maturation and the Nexus of Viral- and Allo-Immunity awarded by National Institutes of Health 2014 - 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Conference Papers

    • Zhu, LM, Fang, YS, Sun, ZG, Yu, LZ, and Xu, H. "Monocyte-derived CD40 expression is regulated by interferon-γ/interferon-γ receptor-1 pathway when acting as a bridge during their interaction with T cells and allogeneic endothelial cells." May 2012.  Full Text
    • Xu, H, Gundry, SR, Hancock, W, Matsumiya, G, and Bailey, LL. "Delayed cardiac xenograft rejection in a pig-to-baboon model treated with a tolerance-inducing regimen and donor bone marrow infusion." August 2000.  Full Text
    • Xu, H, Gundry, SR, Hancock, WW, Zuppan, C, Izutani, H, and Bailey, LL. "Effects of pretransplant splenectomy and immunosuppression of humoral immunity in a pig-to-newborn goat cardiac xenograft model." August 2000.  Full Text
    • Xu, H, Gundry, SR, Hancock, WW, Izutani, H, Zuppan, CW, and Bailey, LL. "Effects of immunosuppression and pretransplant splenectomy in newborn cardiac xenograft survival." June 1998.  Full Text

  • Journal Articles

    • Xu, H, Bendersky, VA, Brennan, TV, Espinosa, JR, and Kirk, AD. "IL-7 receptor heterogeneity as a mechanism for repertoire change during postdepletional homeostatic proliferation and its relation to costimulation blockade-resistant rejection." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons 18, no. 3 (March 2018): 720-730.  Full Text
    • Xu, H, Ostbye, T, Vorderstrasse, AA, Dupre, ME, and Wu, B. "Place of Residence and Cognitive Function among the Adult Population in India." Neuroepidemiology 50, no. 3-4 (January 2018): 119-127.  Full Text
    • Manook, M, Kwun, J, Burghuber, C, Samy, K, Mulvihill, M, Yoon, J, Xu, H, MacDonald, AL, Freischlag, K, Curfman, V, Branum, E, Howell, D, Farris, AB, Smith, RA, Sacks, S, Dorling, A, Mamode, N, and Knechtle, SJ. "Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 8 (August 2017): 2055-2064.  Full Text
    • Xu, H, Samy, KP, Guasch, A, Mead, SI, Ghali, A, Mehta, A, Stempora, L, and Kirk, AD. "Postdepletion Lymphocyte Reconstitution During Belatacept and Rapamycin Treatment in Kidney Transplant Recipients." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 2 (February 2016): 550-564.  Full Text
    • Kirk, AD, Guasch, A, Xu, H, Cheeseman, J, Mead, SI, Ghali, A, Mehta, AK, Wu, D, Gebel, H, Bray, R, Horan, J, Kean, LS, Larsen, CP, and Pearson, TC. "Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 5 (May 2014): 1142-1151.  Full Text
    • Xu, H, Perez, SD, Cheeseman, J, Mehta, AK, and Kirk, AD. "The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 2 (February 2014): 319-332.  Full Text
    • Liu, Z, Fang, Y, Wang, X, Wang, P, Yun, P, and Xu, H. "Upregulation of molecules associated with T-regulatory function by thymoglobulin pretreatment of human CD4+ cells." Transplantation 86, no. 10 (November 2008): 1419-1426.  Full Text
    • Fang, Y, Liu, Z, Zhu, L, Wang, P, Wang, Y, and Xu, H. "CD4+ T-cell and monocyte interdependence during discordant xenoimmune responses." Transplantation Proceedings 40, no. 8 (October 2008): 2764-2768.  Full Text
    • Liu, Z, Zhu, B, Wang, X, Jing, Y, Wang, P, and Xu, H. "Reduced antigenicity of formaldehyde-fixed arterial allografts and their potential clinical application." Transplantation Proceedings 40, no. 8 (October 2008): 2750-2754.  Full Text
    • Wang, P, Liu, Z, Wu, C, Zhu, B, Wang, Y, and Xu, H. "Evaluation of CD86/CD28 and CD40/CD154 pathways in regulating monocyte-derived CD80 expression during their interaction with allogeneic endothelium." Transplantation Proceedings 40, no. 8 (October 2008): 2729-2733.  Full Text
    • Zhu, B, Liu, Z, Wang, P, Wu, C, and Xu, H. "A nuclear factor-kappaB inhibitor BAY11-7082 inhibits interactions between human endothelial cells, T cells, and monocytes." Transplantation Proceedings 40, no. 8 (October 2008): 2724-2728.  Full Text
    • Zhu, L, Fang, Y, Liu, Z, Wang, P, Wang, Y, and Xu, H. "Rabbit anti-human leukocyte polyclonal antibody inhibits xenogeneic cell-mediated immune responses." Transplantation Proceedings 40, no. 8 (October 2008): 2760-2763.  Full Text
    • Wang, X, Liu, Z, Zhu, B, Wang, P, Wu, C, and Xu, H. "Molecular characterization of hypoxia-hypothermia-conditioned human endothelial cells and their interaction with human monocytes." Transplantation Proceedings 40, no. 7 (September 2008): 2127-2135.  Full Text
    • Zhu, B, Liu, Z, Wu, C, Wang, P, Wang, X, and Xu, H. "Conversion from mycophenolate mofetil to azathioprine in renal allograft [corrected] patients within the first month posttransplantation." Transplantation Proceedings 40, no. 7 (September 2008): 2258-2261.  Full Text
    • Liu, Z, Zhu, B, Yun, P, Wang, P, Wang, X, and Xu, H. "Are we ready to utilize non-heart-beating donors for clinical allotransplantation in China?." Transplantation Proceedings 40, no. 4 (May 2008): 1018-1020.  Full Text
    • Pearl, JP, Xu, H, Leopardi, F, Preston, E, and Kirk, AD. "CD154 blockade, sirolimus, and donor-specific transfusion prevents renal allograft rejection in cynomolgus monkeys despite homeostatic T-cell activation." Transplantation 83, no. 9 (May 2007): 1219-1225.  Full Text
    • Xu, H, Dhanireddy, KK, and Kirk, AD. "Human monocytes as intermediaries between allogeneic endothelial cells and allospecific T cells: a role for direct scavenger receptor-mediated endothelial membrane uptake in the initiation of alloimmunity." Journal of immunology (Baltimore, Md. : 1950) 176, no. 2 (January 2006): 750-761.  Full Text
    • Xu, H, Zhang, X, Mannon, RB, and Kirk, AD. "Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154." Journal of Clinical Investigation 116, no. 3 (2006): 769-774.  Full Text  Link to Item
    • Cendales, LC, Xu, H, Bacher, J, Eckhaus, MA, Kleiner, DE, and Kirk, AD. "Composite tissue allotransplantation: development of a preclinical model in nonhuman primates." Transplantation 80, no. 10 (November 2005): 1447-1454.  Full Text
    • Preston, EH, Xu, H, Dhanireddy, KK, Pearl, JP, Leopardi, FV, Starost, MF, Hale, DA, and Kirk, AD. "IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 5, no. 5 (May 2005): 1032-1041.  Full Text
    • Dhanireddy, KK, Xu, H, Mannon, RB, Hale, DA, and Kirk, AD. "The clinical application of monoclonal antibody therapies in renal transplantation." Expert Opinion on Emerging Drugs 9, no. 1 (May 2004): 23-37. (Review)  Full Text
    • Xu, H, Elster, EA, Blair, PJ, Burkly, LC, Tadaki, DK, Harlan, DM, and Kirk, AD. "Effects of combined treatment with CD25- and CD154-specific monoclonal antibodies in non-human primate allotransplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 3, no. 11 (November 2003): 1350-1354.  Full Text
    • Hirshberg, B, Preston, EH, Xu, H, Tal, MG, Neeman, Z, Bunnell, D, Soleimanpour, S, Hale, DA, Kirk, AD, and Harlan, DM. "Rabbit antithymocyte globulin induction and sirolimus monotherapy supports prolonged islet allograft function in a nonhuman primate islet transplantation model." Transplantation 76, no. 1 (July 2003): 55-60.  Full Text
    • Xu, H, Montgomery, SP, Preston, EH, Tadaki, DK, Hale, DA, Harlan, DM, and Kirk, AD. "Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation." Journal of immunology (Baltimore, Md. : 1950) 170, no. 5 (March 2003): 2776-2782.  Full Text
    • Montgomery, SP, Xu, H, Tadaki, DK, Celniker, A, Burkly, LC, Berning, JD, Cruzata, F, Elster, EA, Gray, G, Kampen, RL, Swanson, SJ, Harlan, DM, and Kirk, AD. "Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation." Transplantation 74, no. 10 (November 2002): 1365-1369.  Full Text
    • Xu, H, Tadaki, DK, Elster, EA, Burkly, LC, Berning, JD, Cruzata, F, Kampen, RL, Montgomery, SP, Patterson, NB, Harlan, DM, and Kirk, AD. "Humanized anti-CD154 antibody therapy for the treatment of allograft rejection in nonhuman primates." Transplantation 74, no. 7 (October 2002): 940-943.  Full Text
    • Hirshberg, B, Montgomery, S, Wysoki, MG, Xu, H, Tadaki, D, Lee, J, Hines, K, Gaglia, J, Patterson, N, Leconte, J, Hale, D, Chang, R, Kirk, AD, and Harlan, DM. "Pancreatic islet transplantation using the nonhuman primate (rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site." Diabetes 51, no. 7 (July 2002): 2135-2140.  Full Text
    • Montgomery, SP, Mog, SR, Xu, H, Tadaki, DK, Hirshberg, B, Berning, JD, Leconte, J, Harlan, DM, Hale, D, and Kirk, AD. "Efficacy and toxicity of a protocol using sirolimus, tacrolimus and daclizumab in a nonhuman primate renal allotransplant model." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2, no. 4 (April 2002): 381-385.  Full Text
    • Xu, H, Arnaud, F, Tadaki, DK, Burkly, LC, Harlan, DM, and Kirk, AD. "Human platelets activate porcine endothelial cells through a CD154-dependent pathway." Transplantation 72, no. 11 (December 2001): 1858-1861.  Full Text
    • Elster, EA, Xu, H, Tadaki, DK, Montgomery, S, Burkly, LC, Berning, JD, Baumgartner, RE, Cruzata, F, Marx, R, Harlan, DM, and Kirk, AD. "Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates." Transplantation 72, no. 9 (November 2001): 1473-1478.  Full Text
    • Kirk, AD, Tadaki, DK, Celniker, A, Batty, DS, Berning, JD, Colonna, JO, Cruzata, F, Elster, EA, Gray, GS, Kampen, RL, Patterson, NB, Szklut, P, Swanson, J, Xu, H, and Harlan, DM. "Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primates." Transplantation 72, no. 3 (August 2001): 377-384.  Full Text
    • Xu, H, Elster, E, Batty, D, Berning, J, Burkly, L, Kampen, R, Swanson, S, Tadaki, D, Harlan, D, and Kirk, A. "Effects of dose and duration of anti-CD154 antibody therapy in preventing renal allograft rejection in a nonhuman primate model." Transplantation proceedings 33, no. 1-2 (February 2001): 223-224.  Full Text
    • Xu, H, Gundry, SR, Hancock, WW, Matsumiya, G, Zuppan, CW, Morimoto, T, Slater, J, and Bailey, LL. "Prolonged discordant xenograft survival and delayed xenograft rejection in a pig-to-baboon orthotopic cardiac xenograft model." The Journal of Thoracic and Cardiovascular Surgery 115, no. 6 (June 1998): 1342-1349.  Full Text
    • Xu, H, Gundry, SR, Hill, AC, Zuppan, CW, Morimoto, T, Matsumiya, G, Fagoaga, O, and Bailey, LL. "Prolonged discordant cardiac xenograft survival in newborn recipients." Circulation 96, no. 9 Suppl (November 1997): II-364-7-null.
    • Matsumiya, G, Bailey, LL, Gundry, SR, Morimoto, T, Tran, DD, Xu, H, and Zuppan, CW. "Right ventricular outflow tract reconstruction using a Gore-Tex membrane monocusp valve in infant goats." Chest 110, no. 4 SUPPL. (October 1, 1996).
    • Xu, H, Oluwole, SF, Edwards, NM, Chen, JM, Naka, Y, Kim, E, and Michler, RE. "In vitro evaluation of neonatal human immunity against the pig." The Journal of Thoracic and Cardiovascular Surgery 111, no. 5 (May 1996): 920-929.  Full Text
    • Michler, RE, O'Hair, DP, Xu, H, Shah, AS, and Itescu, S. "Newborn baboon immunity: lessons in cross-species transplantation." The Annals of Thoracic Surgery 60, no. 6 Suppl (December 1995): S582-S584.  Full Text
    • Xu, H, Edwards, N, Chen, JM, Dong, X, and Michler, RE. "Age-related development of human anti-pig xenoantibody." The Journal of Thoracic and Cardiovascular Surgery 110, no. 4 Pt 1 (October 1995): 1023-1029.  Full Text
    • Neethling, F, Cooper, DK, Xu, H, and Michler, RE. "Newborn baboon serum anti-alpha galactosyl antibody levels and cytotoxicity to cultured pig kidney (PK15) cells." Transplantation 60, no. 5 (September 1995): 520-521. (Letter)
    • Xu, H, Edwards, NM, Chen, JM, Kwiatkowski, P, Rosenberg, SE, and Michler, RE. "Newborn baboon serum lacks natural anti-pig xenoantibody." Transplantation 59, no. 8 (April 1995): 1189-1194.
    • Kaplon, RJ, Platt, JL, Kwiatkowski, PA, Edwards, NM, Xu, H, Shah, AS, Masroor, S, and Michler, RE. "Absence of hyperacute rejection in pig-to-primate orthotopic pulmonary xenografts." Transplantation 59, no. 3 (February 1995): 410-416.
    • Kaplon, RJ, Michler, RE, Xu, H, Kwiatkowski, PA, Edwards, NM, and Platt, JL. "Absence of hyperacute rejection in newborn pig-to-baboon cardiac xenografts." Transplantation 59, no. 1 (January 1995): 1-6.

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