Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Research Fellowship, Transplantation Branch, National Institutes of Health 1999 - 2001
  • Surgical Research Fellowship, Surgery, Loma Linda University 1995 - 1997
  • Postdoctoral Research Scientist, Surgery, Columbia University 1991 - 1992
  • PostdoctoralResearch Fellow, Surgery, Columbia University 1988 - 1990
  • Cardiothoracic Fellowship, Surgery, Capital Institute of Medicine (China) 1986 - 1988
  • Resident, Surgery, Capital Institute of Medicine (China) 1983 - 1986
  • M.D., Hebei Medical College (China) 1983
• 

  Duke Appointment History

  • Instructor, Temporary in the Department of Surgery, Surgery, Surgical Sciences, Surgery 2014
• Research
• 

  Selected Grants

  • Phase 2 Study of Belatacept, Alemtuzumab, and Sirolimus in Renal Transplantation awarded by Food and Drug Administration 2015 - 2020
  • T Cell Maturation and the Nexus of Viral- and Allo-Immunity awarded by National Institutes of Health 2014 - 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Journal Articles

    • Xu, H, Ostbye, T, Vorderstrasse, AA, Dupre, ME, and Wu, B. "Place of Residence and Cognitive Function among the Adult Population in India." Neuroepidemiology 50, no. 3-4 (March 7, 2018): 119-127.  Full Text
    • Xu, H, Bendersky, VA, Brennan, TV, Espinosa, JR, and Kirk, AD. "IL-7 receptor heterogeneity as a mechanism for repertoire change during postdepletional homeostatic proliferation and its relation to costimulation blockade-resistant rejection." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (November 14, 2017).  Full Text
    • Manook, M, Kwun, J, Burghuber, C, Samy, K, Mulvihill, M, Yoon, J, Xu, H, MacDonald, AL, Freischlag, K, Curfman, V, Branum, E, Howell, D, Farris, AB, Smith, RA, Sacks, S, Dorling, A, Mamode, N, and Knechtle, SJ. "Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 8 (August 2017): 2055-2064.  Full Text
    • Xu, H, Samy, KP, Guasch, A, Mead, SI, Ghali, A, Mehta, A, Stempora, L, and Kirk, AD. "Postdepletion Lymphocyte Reconstitution During Belatacept and Rapamycin Treatment in Kidney Transplant Recipients." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 16, no. 2 (February 2016): 550-564.  Full Text
    • Kirk, AD, Guasch, A, Xu, H, Cheeseman, J, Mead, SI, Ghali, A, Mehta, AK, Wu, D, Gebel, H, Bray, R, Horan, J, Kean, LS, Larsen, CP, and Pearson, TC. "Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 5 (May 2014): 1142-1151.  Full Text
    • Xu, H, Perez, SD, Cheeseman, J, Mehta, AK, and Kirk, AD. "The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14, no. 2 (February 2014): 319-332.  Full Text
    • Pearl, JP, Xu, H, Leopardi, F, Preston, E, and Kirk, AD. "CD154 blockade, sirolimus, and donor-specific transfusion prevents renal allograft rejection in cynomolgus monkeys despite homeostatic T-cell activation." Transplantation 83, no. 9 (May 2007): 1219-1225.  Full Text
    • Xu, P-T, Li, Y-J, Qin, X-J, Scherzer, CR, Xu, H, Schmechel, DE, Hulette, CM, Ervin, J, Gullans, SR, Haines, J, Pericak-Vance, MA, and Gilbert, JR. "Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease." Neurobiology of disease 21, no. 2 (February 2006): 256-275.  Full Text
    • Xu, H, Dhanireddy, KK, and Kirk, AD. "Human monocytes as intermediaries between allogeneic endothelial cells and allospecific T cells: a role for direct scavenger receptor-mediated endothelial membrane uptake in the initiation of alloimmunity." Journal of immunology (Baltimore, Md. : 1950) 176, no. 2 (January 2006): 750-761.  Full Text
    • Xu, H, Zhang, X, Mannon, RB, and Kirk, AD. "Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154." Journal of Clinical Investigation 116, no. 3 (2006): 769-774.  Full Text  Link to Item
    • Cendales, LC, Xu, H, Bacher, J, Eckhaus, MA, Kleiner, DE, and Kirk, AD. "Composite tissue allotransplantation: development of a preclinical model in nonhuman primates." Transplantation 80, no. 10 (November 2005): 1447-1454.  Full Text
    • Preston, EH, Xu, H, Dhanireddy, KK, Pearl, JP, Leopardi, FV, Starost, MF, Hale, DA, and Kirk, AD. "IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 5, no. 5 (May 2005): 1032-1041.  Full Text
    • Dhanireddy, KK, Xu, H, Mannon, RB, Hale, DA, and Kirk, AD. "The clinical application of monoclonal antibody therapies in renal transplantation." Expert opinion on emerging drugs 9, no. 1 (May 2004): 23-37. (Review)  Full Text
    • Xu, H, Elster, EA, Blair, PJ, Burkly, LC, Tadaki, DK, Harlan, DM, and Kirk, AD. "Effects of combined treatment with CD25- and CD154-specific monoclonal antibodies in non-human primate allotransplantation." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 3, no. 11 (November 2003): 1350-1354.  Full Text
    • Hirshberg, B, Preston, EH, Xu, H, Tal, MG, Neeman, Z, Bunnell, D, Soleimanpour, S, Hale, DA, Kirk, AD, and Harlan, DM. "Rabbit antithymocyte globulin induction and sirolimus monotherapy supports prolonged islet allograft function in a nonhuman primate islet transplantation model." Transplantation 76, no. 1 (July 2003): 55-60.  Full Text
    • Xu, H, Montgomery, SP, Preston, EH, Tadaki, DK, Hale, DA, Harlan, DM, and Kirk, AD. "Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation." Journal of immunology (Baltimore, Md. : 1950) 170, no. 5 (March 2003): 2776-2782.  Full Text
    • Montgomery, SP, Xu, H, Tadaki, DK, Celniker, A, Burkly, LC, Berning, JD, Cruzata, F, Elster, EA, Gray, G, Kampen, RL, Swanson, SJ, Harlan, DM, and Kirk, AD. "Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation." Transplantation 74, no. 10 (November 2002): 1365-1369.  Full Text
    • Xu, H, Tadaki, DK, Elster, EA, Burkly, LC, Berning, JD, Cruzata, F, Kampen, RL, Montgomery, SP, Patterson, NB, Harlan, DM, and Kirk, AD. "Humanized anti-CD154 antibody therapy for the treatment of allograft rejection in nonhuman primates." Transplantation 74, no. 7 (October 2002): 940-943.  Full Text
    • Hirshberg, B, Montgomery, S, Wysoki, MG, Xu, H, Tadaki, D, Lee, J, Hines, K, Gaglia, J, Patterson, N, Leconte, J, Hale, D, Chang, R, Kirk, AD, and Harlan, DM. "Pancreatic islet transplantation using the nonhuman primate (rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site." Diabetes 51, no. 7 (July 2002): 2135-2140.  Full Text
    • Montgomery, SP, Mog, SR, Xu, H, Tadaki, DK, Hirshberg, B, Berning, JD, Leconte, J, Harlan, DM, Hale, D, and Kirk, AD. "Efficacy and toxicity of a protocol using sirolimus, tacrolimus and daclizumab in a nonhuman primate renal allotransplant model." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2, no. 4 (April 2002): 381-385.  Full Text
    • Xu, H, Arnaud, F, Tadaki, DK, Burkly, LC, Harlan, DM, and Kirk, AD. "Human platelets activate porcine endothelial cells through a CD154-dependent pathway." Transplantation 72, no. 11 (December 2001): 1858-1861.  Full Text
    • Elster, EA, Xu, H, Tadaki, DK, Montgomery, S, Burkly, LC, Berning, JD, Baumgartner, RE, Cruzata, F, Marx, R, Harlan, DM, and Kirk, AD. "Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates." Transplantation 72, no. 9 (November 2001): 1473-1478.  Full Text
    • Kirk, AD, Tadaki, DK, Celniker, A, Batty, DS, Berning, JD, Colonna, JO, Cruzata, F, Elster, EA, Gray, GS, Kampen, RL, Patterson, NB, Szklut, P, Swanson, J, Xu, H, and Harlan, DM. "Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primates." Transplantation 72, no. 3 (August 2001): 377-384.  Full Text
    • Xu, H, Elster, E, Batty, D, Berning, J, Burkly, L, Kampen, R, Swanson, S, Tadaki, D, Harlan, D, and Kirk, A. "Effects of dose and duration of anti-CD154 antibody therapy in preventing renal allograft rejection in a nonhuman primate model." Transplantation proceedings 33, no. 1-2 (February 2001): 223-224.  Full Text
    • Rotolo, FS, Watters, CR, Xu, H, Quarfordt, SH, and Meyers, WC. "Regulation of biliary protein secretion in dogs." Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 187, no. 2 (February 1988): 149-156.

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