Current Appointments & Affiliations
Associate Professor of Surgery
·
2023 - Present
Surgery, Surgical Sciences,
Surgery
Recent Publications
Immunomodulation of T cell-mediated alloimmunity by proximity to endothelial cells under the mammalian target of rapamycin blockade.
Journal Article Am J Transplant · February 2025 Endothelial cells (ECs) are an initial barrier between vascularized organ allografts and the host immune system and are thus well positioned to initiate and influence alloimmune rejection. The mammalian target of rapamycin inhibitor rapamycin is known to i ... Full text Link to item CiteRapamycin Prevents Expansion of Costimulation Blockade-resistant CD8+ Alloreactive Memory Cells following Depletional Induction in Renal Transplant Recipients.
Journal Article J Immunol · November 1, 2024 Alemtuzumab induction with belatacept/rapamycin-based maintenance immunotherapy (ABR) prevents kidney allograft rejection and specifically limits early costimulation blockade-resistant rejection (CoBRR). To evaluate the mechanisms by which this regimen alt ... Full text Open Access Link to item CiteThe Role of Autophagy in Vascular Endothelial Cell Health and Physiology.
Journal Article Cells · May 2024 Autophagy is a highly conserved cellular recycling process which enables eukaryotes to maintain both cellular and overall homeostasis through the catabolic breakdown of intracellular components or the selective degradation of damaged organelles. In recent ... Full text CiteRecent Grants
A CD6-targeted antibody conjugate (CD6-ADC) selectively ablates alloreactive proliferating T cells in humans and non-human primates (NHPs)
ResearchInvestigator · Awarded by Massachusetts General Hospital · 2024 - 2027Neonatal porcine islet xenografts for the treatment of type 1 diabetes
ResearchInvestigator · Awarded by National Institute of Allergy and Infectious Diseases · 2014 - 2025Phase 2 Study of Belatacept, Alemtuzumab, and Sirolimus in Renal Transplantation
ResearchCo Investigator · Awarded by Food and Drug Administration · 2015 - 2020View All Grants
Education, Training & Certifications
Hebei Medical College (China) ·
1983
M.D.