Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Pediatric Rheumatology Fellowship, Pediatrics, University of Michigan, Ann Arbor 2006 - 2009
  • Fellowship in Pediatric Health Services Research, Pediatrics, University of Michigan, Ann Arbor 2007 - 2008
  • Pediatric Chief Resident, Pediatrics, University of Michigan, Ann Arbor 2004 - 2005
  • Pediatrics Residency, Pediatrics, University of Michigan, Ann Arbor 2001 - 2004
  • M.D., University of Rochester 2001
• 

  Previous Appointments & Affiliations

  • Associate Professor of Pediatrics, Pediatrics, Rheumatology, Pediatrics 2017 - 2020
  • Assistant Professor of Pediatrics, Pediatrics, Rheumatology, Pediatrics 2009 - 2017
• 

  Leadership & Clinical Positions at Duke

  • Pediatric Rheumatology Fellowship Associate Program Director
    Combined Medicine and Pediatric Rheumatology Fellowship Director
    Co-Director of the Pediatric Autoimmune Brain Disease Program
• Recognition
• 

  In the News

  • JUN 21, 2016

    The Atlantic

    When the Body Attacks the Mind
• Expertise
• 

  Subject Headings

  • Adolescent
  • Child
  • Comparative Effectiveness Research
  • Encephalitis
  • Psychometrics
  • Quality of Life
  • Rheumatoid arthritis in children
  • Systemic Vasculitis
  • Treatment Outcome
  • Vasculitis
  • Vasculitis, Central Nervous System
• Research
• 

  Selected Grants

  • Arthritis Foundation Fellowship Training Grant 2019 awarded by Arthritis Foundation 2020 - 2023
  • A Phase 2/3 Open-Label, Single-Arm Trial to Evaluate the Safety and Activity of Eculizumab in Pediatric Patients with Relapsing Neuromyelitis Optica Spectrum Disorder awarded by Alexion Pharmaceuticals, Inc. 2020 - 2022
  • ACR/Amgen Rheumatology Fellowship Training Award awarded by Rheumatology Research Foundation 2020 - 2021
  • RRF Medical and Graduate Student Preceptorship awarded by Rheumatology Research Foundation 2020
  • ACR/Amgen Rheumatology Fellowship Training Award awarded by Rheumatology Research Foundation 2016 - 2017
  • ACR/Amgen Rheumatology Fellowship Training Award awarded by Rheumatology Research Foundation 2015 - 2016
  • Phase 2 - The Effectiveness of Disease-Modifying Anti-Rheumatic Drugs in Children with Juvenile Idiopathic Arthritis awarded by Agency for Healthcare Research and Quality 2009 - 2011
  • Phase 1 - The Effectiveness of Disease-modifying Anti-rheumatic Drugs in Children with Juvenile Idiopathic Arthritis awarded by Agency for Healthcare Research and Quality 2009
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Randell, Rachel L., Sara M. Stern, Heather Van Mater, Laura E. Schanberg, Scott M. Lieberman, Matthew L. Basiaga, Matthew L. CARRA Sjögren Workgroup, and Matthew L. CARRA Investigators. “Pediatric rheumatologists' perspectives on diagnosis, treatment, and outcomes of Sjögren disease in children and adolescents.” Pediatr Rheumatol Online J 20, no. 1 (September 5, 2022): 79. https://doi.org/10.1186/s12969-022-00740-4.
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    • Santoro, Jonathan D., Rebecca Partridge, Runi Tanna, Dania Pagarkar, Mellad Khoshnood, Mustafa Rehmani, Ryan M. Kammeyer, et al. “Evidence of neuroinflammation and immunotherapy responsiveness in individuals with down syndrome regression disorder.” J Neurodev Disord 14, no. 1 (June 3, 2022): 35. https://doi.org/10.1186/s11689-022-09446-w.
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    • Cannon, Laura, David Van Mater, Heather Van Mater, and Mara Becker. “Eye Swelling and Weight Loss in an 18-year-old Adolescent.” Pediatr Rev 43, no. 6 (June 1, 2022): 350–52. https://doi.org/10.1542/pir.2020-004891.
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    • Gorelik, Mark, Sharon A. Chung, Kaveh Ardalan, Bryce A. Binstadt, Kevin Friedman, Kristen Hayward, Lisa F. Imundo, et al. “2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Kawasaki Disease.” Arthritis Care Res (Hoboken) 74, no. 4 (April 2022): 538–48. https://doi.org/10.1002/acr.24838.
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    • Gorelik, Mark, Sharon A. Chung, Kaveh Ardalan, Bryce A. Binstadt, Kevin Friedman, Kristen Hayward, Lisa F. Imundo, et al. “2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Kawasaki Disease.” Arthritis Rheumatol 74, no. 4 (April 2022): 586–96. https://doi.org/10.1002/art.42041.
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    • Harmon, Alexis, Cory Stingl, Aruna Rikhi, Linh Tran, Carolyn Pizoli, Michael Malinzak, and Heather Van Mater. “Pediatric GAD-65 Autoimmune Encephalitis: Assessing Clinical Characteristics and Response to Therapy With a Novel Assessment Scale.” Pediatr Neurol 128 (March 2022): 25–32. https://doi.org/10.1016/j.pediatrneurol.2021.12.007.
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    • Taylor, Kathryn, Eyal Muscal, and Heather Van Mater. “The Role of Pediatric Rheumatologists in Autoimmune Brain Disease.” Rheum Dis Clin North Am 48, no. 1 (February 2022): 343–69. https://doi.org/10.1016/j.rdc.2021.09.002.
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    • Santoro, Jonathan D., Lina Patel, Ryan Kammeyer, Robyn A. Filipink, Grace Y. Gombolay, Kathleen M. Cardinale, Diego Real de Asua, et al. “Assessment and Diagnosis of Down Syndrome Regression Disorder: International Expert Consensus.” Front Neurol 13 (2022): 940175. https://doi.org/10.3389/fneur.2022.940175.
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    • Nosadini, Margherita, Michael Eyre, Erika Molteni, Terrence Thomas, Sarosh R. Irani, Josep Dalmau, Russell C. Dale, et al. “Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis.” Jama Neurol 78, no. 11 (November 1, 2021): 1333–44. https://doi.org/10.1001/jamaneurol.2021.3188.
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    • Kimura, Yukiko, Laura E. Schanberg, George A. Tomlinson, Mary Ellen Riordan, Anne C. Dennos, Vincent Del Gaizo, Katherine L. Murphy, et al. “Optimizing the Start Time of Biologics in Polyarticular Juvenile Idiopathic Arthritis: A Comparative Effectiveness Study of Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans.” Arthritis Rheumatol 73, no. 10 (October 2021): 1898–1909. https://doi.org/10.1002/art.41888.
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    • Abboud, Hesham, John C. Probasco, Sarosh Irani, Beau Ances, David R. Benavides, Michael Bradshaw, Paulo Pereira Christo, et al. “Autoimmune encephalitis: proposed best practice recommendations for diagnosis and acute management.” J Neurol Neurosurg Psychiatry 92, no. 7 (July 2021): 757–68. https://doi.org/10.1136/jnnp-2020-325300.
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    • Nosadini, Margherita, Terrence Thomas, Michael Eyre, Banu Anlar, Thais Armangue, Susanne M. Benseler, Tania Cellucci, et al. “International Consensus Recommendations for the Treatment of Pediatric NMDAR Antibody Encephalitis.” Neurol Neuroimmunol Neuroinflamm 8, no. 5 (July 2021). https://doi.org/10.1212/NXI.0000000000001052.
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    • Abboud, Hesham, John Probasco, Sarosh R. Irani, Beau Ances, David R. Benavides, Michael Bradshaw, Paulo Pereira Christo, et al. “Autoimmune encephalitis: proposed recommendations for symptomatic and long-term management.” J Neurol Neurosurg Psychiatry 92, no. 8 (March 1, 2021): 897–907. https://doi.org/10.1136/jnnp-2020-325302.
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    • Covert, Lauren, Heather Van Mater, and Benjamin L. Hechler. “Comprehensive Management of Rheumatic Diseases Affecting the Temporomandibular Joint.” Diagnostics (Basel) 11, no. 3 (February 27, 2021). https://doi.org/10.3390/diagnostics11030409.
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    • Cannon, Laura, Heather Van Mater, and Carolyn Pizoli. “Hypersomnolence in a 17-year-old Boy.” Pediatr Rev 42, no. Suppl 1 (January 2021): S82–84. https://doi.org/10.1542/pir.2019-0229.
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    • Hart, Sarah J., Gordon Worley, Priya S. Kishnani, and Heather Van Mater. “Case Report: Improvement Following Immunotherapy in an Individual With Seronegative Down Syndrome Disintegrative Disorder.” Frontiers in Neurology 12 (January 2021): 621637. https://doi.org/10.3389/fneur.2021.621637.
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    • Adams, Ashley V., GenaLynne C. Mooneyham, Heather Van Mater, and William Gallentine. “Evaluation of Diagnostic Criteria for Hashimoto Encephalopathy Among Children and Adolescents.” Pediatr Neurol 107 (June 2020): 41–47. https://doi.org/10.1016/j.pediatrneurol.2019.12.011.
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    • Buckley, Mary, and Heather Van Mater. “Idiopathic Pulmonary Hemosiderosis as a Mimic of Pulmonary Vasculitis: A Case Report and Review of the Literature.” Curr Allergy Asthma Rep 20, no. 5 (April 4, 2020): 13. https://doi.org/10.1007/s11882-020-00907-7.
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    • Cellucci, Tania, Heather Van Mater, Francesc Graus, Eyal Muscal, William Gallentine, Marisa S. Klein-Gitelman, Susanne M. Benseler, et al. “Clinical approach to the diagnosis of autoimmune encephalitis in the pediatric patient.” Neurol Neuroimmunol Neuroinflamm 7, no. 2 (March 2020). https://doi.org/10.1212/NXI.0000000000000663.
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    • Mischel, Nicholas A., GenaLynne C. Mooneyham, Cecilia Lau, Heather Van Mater, and Richard D. Weiner. “Non-N-methyl-D-aspartate Autoimmune Encephalopathy and Catatonia Treated With Electroconvulsive Therapy: A Pediatric Case Series and Treatment Guidelines.” Psychosomatics 61, no. 6 (2020): 834–39. https://doi.org/10.1016/j.psym.2019.12.005.
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    • Coppola, Tiziana, Bradford Becken, Heather Van Mater, Marie Theresa McDonald, and Gabriela Maradiaga Panayotti. “A case report of mevalonate kinase deficiency in a 14-month-old female with fevers and lower extremity weakness.” Bmc Pediatr 19, no. 1 (July 20, 2019): 245. https://doi.org/10.1186/s12887-019-1617-1.
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    • Cardinale, Kathleen M., Alexandra Bocharnikov, Sarah J. Hart, Jane Ann Baker, Christopher Eckstein, Joan M. Jasien, William Gallentine, Gordon Worley, Priya S. Kishnani, and Heather Van Mater. “Immunotherapy in selected patients with Down syndrome disintegrative disorder.” Dev Med Child Neurol 61, no. 7 (July 2019): 847–51. https://doi.org/10.1111/dmcn.14127.
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    • Stingl, Cory, and Heather Van Mater. “Mycophenolate mofetil in the treatment of pediatric autoimmune central nervous system disease.” Dev Med Child Neurol 61, no. 4 (April 2019): 388. https://doi.org/10.1111/dmcn.14098.
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    • Liu, Elina, Marinka Twilt, Pascal N. Tyrrell, Anastasia Dropol, Shehla Sheikh, Mark Gorman, Susan Kim, et al. “Health-related quality of life in children with inflammatory brain disease.” Pediatr Rheumatol Online J 16, no. 1 (November 20, 2018): 73. https://doi.org/10.1186/s12969-018-0291-4.
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    • Randell, Rachel L., Ashley V. Adams, and Heather Van Mater. “Tocilizumab in Refractory Autoimmune Encephalitis: A Series of Pediatric Cases.” Pediatr Neurol 86 (September 2018): 66–68. https://doi.org/10.1016/j.pediatrneurol.2018.07.016.
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    • Mater, Heather van, Stephen J. Balevic, Gary L. Freed, and Sarah J. Clark. “Prescribing for Children With Rheumatic Disease: Perceived Treatment Approaches Between Pediatric and Adult Rheumatologists.” Arthritis Care Res (Hoboken) 70, no. 2 (February 2018): 268–74. https://doi.org/10.1002/acr.23273.
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    • Hechler, B. L., J. A. Phero, H. Van Mater, and N. S. Matthews. “Ultrasound versus magnetic resonance imaging of the temporomandibular joint in juvenile idiopathic arthritis: a systematic review.” Int J Oral Maxillofac Surg 47, no. 1 (January 2018): 83–89. https://doi.org/10.1016/j.ijom.2017.07.014.
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    • Mooneyham, GenaLynne C., William Gallentine, and Heather Van Mater. “Evaluation and Management of Autoimmune Encephalitis: A Clinical Overview for the Practicing Child Psychiatrist.” Child Adolesc Psychiatr Clin N Am 27, no. 1 (January 2018): 37–52. https://doi.org/10.1016/j.chc.2017.08.011.
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    • Kimura, Yukiko, Sriharsha Grevich, Timothy Beukelman, Esi Morgan, Peter A. Nigrovic, Kelly Mieszkalski, T Brent Graham, et al. “Pilot study comparing the Childhood Arthritis & Rheumatology Research Alliance (CARRA) systemic Juvenile Idiopathic Arthritis Consensus Treatment Plans.” Pediatr Rheumatol Online J 15, no. 1 (April 11, 2017): 23. https://doi.org/10.1186/s12969-017-0157-1.
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    • Cabral, David A., Debra L. Canter, Eyal Muscal, Kabita Nanda, Dawn M. Wahezi, Steven J. Spalding, Marinka Twilt, et al. “Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener's): An ARChiVe Cohort Study.” Arthritis Rheumatol 68, no. 10 (October 2016): 2514–26. https://doi.org/10.1002/art.39729.
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    • Van Mater, Heather. “Pediatric inflammatory brain diseases: a diagnostic approach.” Curr Opin Rheumatol 26, no. 5 (September 2014): 553–61. https://doi.org/10.1097/BOR.0000000000000092.
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    • Riebschleger, Meredith P., Heather A. Van Mater, Lisa M. Cohn, and Sarah J. Clark. “Prescription patterns for children with juvenile idiopathic arthritis in Michigan Medicaid: a comparison by prescriber type.” Pediatr Rheumatol Online J 12 (2014): 38. https://doi.org/10.1186/1546-0096-12-38.
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    • Morishita, Kimberly, Jaime Guzman, Peter Chira, Eyal Muscal, Andrew Zeft, Marisa Klein-Gitelman, America G. Uribe, et al. “Do adult disease severity subclassifications predict use of cyclophosphamide in children with ANCA-associated vasculitis? An analysis of ARChiVe study treatment decisions.” J Rheumatol 39, no. 10 (October 2012): 2012–20. https://doi.org/10.3899/jrheum.120299.
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    • Mater, Heather A. van, John W. Williams, Remy R. Coeytaux, Gillian D. Sanders, and Alex R. Kemper. “Psychometric characteristics of outcome measures in juvenile idiopathic arthritis: a systematic review.” Arthritis Care Res (Hoboken) 64, no. 4 (April 2012): 554–62. https://doi.org/10.1002/acr.20667.
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    • Kemper, Alex R., Heather A. Van Mater, Remy R. Coeytaux, John W. Williams, and Gillian D. Sanders. “Systematic review of disease-modifying antirheumatic drugs for juvenile idiopathic arthritis.” Bmc Pediatr 12 (March 15, 2012): 29. https://doi.org/10.1186/1471-2431-12-29.
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  • Book Sections

    • Tran, P., J. Frankovich, H. Van Mater, R. C. Dale, N. Or-Geva, A. McHugh, and M. Thienemann. “Pediatric Inflammatory Brain Disease.” In Complex Disorders in Pediatric Psychiatry: A Clinician’s Guide, 169–88, 2018. https://doi.org/10.1016/B978-0-323-51147-6.00014-4.
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  • Conference Papers

    • Jones, Jordan T., Chelsey Smith, Mara L. Becker, Daniel Lovell, and Daniel CARRA Registry Investigators. “Down Syndrome-Associated Arthritis Cohort in the New Childhood Arthritis and Rheumatology Research Alliance Registry: Clinical Characteristics, Treatment, and Outcomes.” In Arthritis Care Res (Hoboken), 73:1739–45, 2021. https://doi.org/10.1002/acr.24418.
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    • Van Mater, Heather A. “2.3 BEHCET’S TO SJOGREN’S: THE ABCS OF AUTOIMMUNE BRAIN DISORDERS.” In Journal of the American Academy of Child &Amp; Adolescent Psychiatry, 58:S131–32. Elsevier BV, 2019. https://doi.org/10.1016/j.jaac.2019.07.625.
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    • Adams, Ashley V., William Gallentine, Heather A. Van Mater, and GenaLynne C. Mooneyham. “4.36 Identification of Clinical Phenotypes Within Seropositive Autoimmune Encephalitis Among Children and Adolescents.” In Journal of the American Academy of Child &Amp; Adolescent Psychiatry, 57:S216–S216. Elsevier BV, 2018. https://doi.org/10.1016/j.jaac.2018.09.262.
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    • Adams, Ashley V., William Gallentine, Heather A. Van Mater, and GenaLynne C. Mooneyham. “4.37 Evaluation of Diagnostic Criteria for Hashimoto's Encephalopathy in Children and Adolescents.” In Journal of the American Academy of Child &Amp; Adolescent Psychiatry, 57:S216–S216. Elsevier BV, 2018. https://doi.org/10.1016/j.jaac.2018.09.263.
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    • Van Mater, Heather A. “16.4 Treatment Approaches in the Management of Autoimmune Encephalopathy.” In Journal of the American Academy of Child &Amp; Adolescent Psychiatry, 57:S25–S25. Elsevier BV, 2018. https://doi.org/10.1016/j.jaac.2018.07.106.
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    • Van Mater, Heather A. “23.4 Treatment Considerations in Autoimmune Encephalopathy.” In Journal of the American Academy of Child &Amp; Adolescent Psychiatry, 56:S34–35. Elsevier BV, 2017. https://doi.org/10.1016/j.jaac.2017.07.135.
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