Skip to main content

Henry Hsien-Chun Tseng

Associate Professor of Ophthalmology
Ophthalmology, Glaucoma
Dukeeye Center, DUMC 3802, Durham, NC 27710
Duke Eye Center, 2351 Erwin Road, DUMC 3802, Durham, NC 27710

Overview


Dr. Tseng is a board-certified and fellowship-trained ophthalmologist in the diagnosis and treatment of glaucoma and cataracts. He is skilled in glaucoma laser and incisional surgical therapies. He also performs cataract surgery using the latest technology, such as femtosecond laser and multifocal intraocular lenses for multifocal vision correction.

Dr. Tseng is also a neuroscience, laboratory-trained clinician-scientist dedicated to both clinical and cutting-edge research into vision loss in glaucoma. The ultiĀ­mate research goal is to develop novel therapies and techniques for earlier detection of glaucoma and neurodegeneration. Dr. Tseng's research investigates molecular and cellular functions of optineurin, which is a gene associated with glaucoma, brain neurodegeneration, and Paget's disease of the bone. He is uncovering common disease mechanisms that leads to cell death in the eye, brain, and bone. Since the bone marrow is the primary source of stem cells, this work will reveal new insights into the development of regenerative and pharmacological therapies.

Current Appointments & Affiliations


Associate Professor of Ophthalmology · 2021 - Present Ophthalmology, Glaucoma, Ophthalmology

Recent Publications


Accelerated Epigenetic Aging Is Associated with Faster Glaucoma Progression: A DNA Methylation Study.

Journal Article Ophthalmology · December 21, 2024 PURPOSE: To investigate the association between epigenetic age acceleration and glaucoma progression. DESIGN: Retrospective cohort study. PARTICIPANTS: A total of 100 patients with primary open-angle glaucoma (POAG) with fast progression and 100 patients w ... Full text Link to item Cite

Age-related effects of optineurin deficiency in the mouse eye.

Journal Article Vision Res · November 2024 Optineurin (OPTN) is a gene associated with familial normal tension glaucoma (NTG). While NTG involves intraocular pressure (IOP)-independent neurodegeneration of the visual pathway that progresses with age, how OPTN dysfunction leads to NTG remains unclea ... Full text Link to item Cite

Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study.

Journal Article Ophthalmology · June 2024 PURPOSE: To evaluate the performance of an intensive, clustered testing approach in identifying eyes with rapid glaucoma progression over 6 months in the Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study. DESIGN: Prospective cohort ... Full text Link to item Cite
View All Publications

Recent Grants


Respiratory Dysfunction in an Optineurin knock out ALS mouse model

ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2022

Comparison of Intraocular Pressure Measurements between Reichert Tono-Vera and Goldmann Tonometry

Clinical TrialPrincipal Investigator · Awarded by Reichert Technologies · 2020 - 2022

Phase I Double Blind,Single & Multiple Ascending-Dose Study to Determine Effects of GDC-0134 in Patients w/ ALS

Clinical TrialPrincipal Investigator · Awarded by Wake Research Associates, LLC · 2017 - 2020

View All Grants

Education, Training & Certifications


University of Pennsylvania · 2002 M.D.
University of Pennsylvania · 2001 Ph.D.