Henry Hsien-Chun Tseng | Scholars@Duke

Henry Hsien-Chun Tseng
Associate Professor of Ophthalmology

Dr. Tseng is a board-certified and fellowship-trained ophthalmologist in the diagnosis and treatment of glaucoma and cataracts. He is skilled in glaucoma laser and incisional surgical therapies. He also performs cataract surgery using the latest technology, such as femtosecond laser and multifocal intraocular lenses for multifocal vision correction.

Dr. Tseng is also a neuroscience, laboratory-trained clinician-scientist dedicated to both clinical and cutting-edge research into vision loss in glaucoma. The ultimate research goal is to develop novel therapies and techniques for earlier detection of glaucoma and neurodegeneration. Dr. Tseng's research investigates molecular and cellular functions of optineurin, which is a gene associated with glaucoma, brain neurodegeneration, and Paget's disease of the bone. He is uncovering common disease mechanisms that leads to cell death in the eye, brain, and bone. Since the bone marrow is the primary source of stem cells, this work will reveal new insights into the development of regenerative and pharmacological therapies.

Current Appointments & Affiliations

Associate Professor of Ophthalmology, Ophthalmology, Glaucoma, Ophthalmology 2021

Contact Information

Duke Eye Center, 2351 Erwin Road, DUMC 3802, Durham, NC 27710
Dukeeye Center, DUMC 3802, Durham, NC 27710
henry.tseng@duke.edu (919) 684-8850

Background
Education, Training, & Certifications
- Glaucoma Fellowship, Ophthalmology, Duke University 2007 - 2008
- Ophthalmology, Duke University 2003 - 2006
- Internal Medicine, University of Pennsylvania 2002 - 2003
- M.D., University of Pennsylvania 2002
- Ph.D., University of Pennsylvania 2001
Previous Appointments & Affiliations
- Associate Professor of Ophthalmology, Ophthalmology, Glaucoma, Ophthalmology 2020
- Assistant Professor of Ophthalmology, Ophthalmology, Glaucoma, Ophthalmology 2018 - 2020
- Assistant Professor of Ophthalmology, Ophthalmology, Glaucoma, Ophthalmology 2008 - 2018
- Clinical Associate in the Department of Ophthalmology, Ophthalmology, Glaucoma, Ophthalmology 2007 - 2008
- Clinical Associate in the Department of Ophthalmology, Ophthalmology, Clinical Science Departments 2006 - 2007
- Instructor, Temporary in the Department of Ophthalmology, Ophthalmology, Clinical Science Departments 2006
Research
Selected Grants
- Respiratory Dysfunction in an Optineurin knock out ALS mouse model awarded by National Institutes of Health 2020 - 2022
- Comparison of Intraocular Pressure Measurements between Reichert Tono-Vera and Goldmann Tonometry awarded by Reichert Technologies 2020 - 2022
- Phase I Double Blind,Single & Multiple Ascending-Dose Study to Determine Effects of GDC-0134 in Patients w/ ALS awarded by Wake Research Associates, LLC 2017 - 2020
- The nGoggle: A portable brain-based device for assessment of visual function deficits awarded by nGoggle, Inc 2018 - 2020
- Neurodegenerative biomarkers in primary open angle glaucoma awarded by Cure Glaucoma Foundation 2017 - 2019
- Engineering Novel Bio-Inspired Materials for Stem Cell-Mediated Bone Regeneration awarded by University of North Carolina - Chapel Hill 2014 - 2019
- Disruption of Mitochondria-related Vesicular Traffic by E50K Optineurin awarded by Northeastern Ohio Universities Colleges of Medicine and Pharmacy 2015 - 2018
- Temporal dynamics of retinal ganglion cell neurodegeneration in glaucoma awarded by National Institutes of Health 2015 - 2018
- Age-related autophagy function in an optineurin mouse model of normal-tension glaucoma awarded by American Glaucoma Society 2016 - 2017
- A novel animal model of normal-pressure glaucoma through genetic deletion of optineurin awarded by Alcon Research 2014 - 2016
- Negative regulation of NF-kB by optineurin in primary open angle glaucoma awarded by National Institutes of Health 2011 - 2014
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Patil, Chandrashekhar D., Rahul Suryawanshi, Joshua Ames, Raghuram Koganti, Alex Agelidis, Divya Kapoor, Tejabhiram Yadavalli, Lulia Koujah, Henry C. Tseng, and Deepak Shukla. “Intrinsic Antiviral Activity of Optineurin Prevents Hyperproliferation of a Primary Herpes Simplex Virus Type 2 Infection.” Journal of Immunology (Baltimore, Md. : 1950) 208, no. 1 (January 2022): 63–73. https://doi.org/10.4049/jimmunol.2100472.
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  - Ames, Joshua, Tejabhiram Yadavalli, Rahul Suryawanshi, James Hopkins, Alexander Agelidis, Chandrashekhar Patil, Brian Fredericks, Henry Tseng, Tibor Valyi-Nagy, and Deepak Shukla. “OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection.” Nat Commun 12, no. 1 (September 13, 2021): 5401. https://doi.org/10.1038/s41467-021-25642-z.
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  - Li, Yina, Laura Anne Jacox, Shannon Coats, Jane Kwon, Peng Xue, Na Tang, Zou Rui, et al. “Roles of autophagy in orthodontic tooth movement.” Am J Orthod Dentofacial Orthop 159, no. 5 (May 2021): 582–93. https://doi.org/10.1016/j.ajodo.2020.01.027.
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  - Xue, Peng, Xiangxiang Hu, Emily Chang, Lufei Wang, Minghui Chen, Tai-Hsien Wu, Dong-Joon Lee, Brian L. Foster, Henry C. Tseng, and Ching-Chang Ko. “Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response.” Exp Mol Med 53, no. 4 (April 2021): 667–80. https://doi.org/10.1038/s12276-021-00596-w.
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  - Wong, Sing-Wai, Bo-Wen Huang, Xiangxiang Hu, Eui Ho Kim, Joseph P. Kolb, Ricardo J. Padilla, Peng Xue, et al. “Correction: Global deletion of optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease.” Cell Death Differ 28, no. 2 (February 2021): 825–26. https://doi.org/10.1038/s41418-020-0586-0.
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  - Jammal, Alessandro A., Atalie C. Thompson, Eduardo B. Mariottoni, Carla N. Urata, Tais Estrela, Samuel I. Berchuck, Henry C. Tseng, Sanjay Asrani, and Felipe A. Medeiros. “Rates of Glaucomatous Structural and Functional Change From a Large Clinical Population: The Duke Glaucoma Registry Study.” Am J Ophthalmol 222 (February 2021): 238–47. https://doi.org/10.1016/j.ajo.2020.05.019.
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  - McCall, Angela L., Justin S. Dhindsa, Logan A. Pucci, Amanda F. Khan, Anna F. Fusco, Debolina D. Biswas, Laura M. Strickland, Henry C. Tseng, and Mai K. ElMallah. “Corrigendum to "Respiratory pathology in the optn^-/- mouse model of amyotrophic lateral sclerosis" [Respir. Physiol. Neurobiol. 282 (2020) 103525].” Respiratory Physiology & Neurobiology 284 (February 2021): 103570. https://doi.org/10.1016/j.resp.2020.103570.
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  - Wang, Lufei, Lichi Han, Peng Xue, Xiangxiang Hu, Sing-Wai Wong, Meng Deng, Henry C. Tseng, Bo-Wen Huang, and Ching-Chang Ko. “Dopamine suppresses osteoclast differentiation via cAMP/PKA/CREB pathway.” Cell Signal 78 (February 2021): 109847. https://doi.org/10.1016/j.cellsig.2020.109847.
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  - Wang, Lufei, Dong Joon Lee, Han Han, Lixing Zhao, Hiroshi Tsukamoto, Yong-Il Kim, Adele M. Musicant, et al. “Application of bioluminescence resonance energy transfer-based cell tracking approach in bone tissue engineering.” J Tissue Eng 12 (2021): 2041731421995465. https://doi.org/10.1177/2041731421995465.
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  - McCall, Angela L., Justin S. Dhindsa, Logan A. Pucci, Amanda F. Kahn, Anna F. Fusco, Debolina D. Biswas, Laura M. Strickland, Henry C. Tseng, and Mai K. ElMallah. “Respiratory pathology in the Optn-/- mouse model of Amyotrophic Lateral Sclerosis.” Respir Physiol Neurobiol 282 (November 2020): 103525. https://doi.org/10.1016/j.resp.2020.103525.
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  - Wakil, Susan M., Faith Birnbaum, Daniel M. Vu, Shan McBurney-Lin, Mohammed K. ElMallah, and Henry Tseng. “Efficacy and safety of a single-use dual blade goniotomy: 18-month results.” J Cataract Refract Surg 46, no. 10 (October 2020): 1408–15. https://doi.org/10.1097/j.jcrs.0000000000000263.
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  - VanderWall, Kirstin B., Kang-Chieh Huang, Yanling Pan, Sailee S. Lavekar, Clarisse M. Fligor, Anna R. Allsop, Kelly A. Lentsch, et al. “Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids.” Stem Cell Reports 15, no. 1 (July 14, 2020): 52–66. https://doi.org/10.1016/j.stemcr.2020.05.009.
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  - Umunakwe, Obinna, Divakar Gupta, and Henry Tseng. “Association of Open-Angle Glaucoma with Non-Alzheimer's Dementia and Cognitive Impairment.” Ophthalmol Glaucoma 3, no. 6 (2020): 460–65. https://doi.org/10.1016/j.ogla.2020.06.008.
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  - Wong, Sing-Wai, Bo-Wen Huang, Xiangxiang Hu, Eui Ho Kim, Joseph P. Kolb, Ricardo J. Padilla, Peng Xue, et al. “Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease.” Cell Death Differ 27, no. 1 (January 2020): 71–84. https://doi.org/10.1038/s41418-019-0341-6.
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  - Xue, Peng, Xiangxiang Hu, James Powers, Nicole Nay, Emily Chang, Jane Kwon, Sing Wai Wong, et al. “CDDO-Me, Sulforaphane and tBHQ attenuate the RANKL-induced osteoclast differentiation via activating the NRF2-mediated antioxidant response.” Biochem Biophys Res Commun 511, no. 3 (April 9, 2019): 637–43. https://doi.org/10.1016/j.bbrc.2019.02.095.
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  - Chen, Si, Bing Bai, Dong Joon Lee, Shannon Diachina, Yina Li, Sing Wai Wong, Zhengyan Wang, Henry C. Tseng, and Ching-Chang Ko. “Dopaminergic enhancement of cellular adhesion in bone marrow derived mesenchymal stem cells (MSCs).” J Stem Cell Res Ther 7, no. 8 (August 2017). https://doi.org/10.4172/2157-7633.1000395.
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  - Gupta, Divakar, Joanne C. Wen, Janet L. Huebner, Sandra Stinnett, Virginia B. Kraus, Henry C. Tseng, and Molly Walsh. “Cytokine biomarkers in tear film for primary open-angle glaucoma.” Clin Ophthalmol 11 (2017): 411–16. https://doi.org/10.2147/OPTH.S125364.
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  - Mukherjee, Nisha, Shan McBurney-Lin, Anthony Kuo, Richard Bedlack, and Henry Tseng. “Retinal thinning in amyotrophic lateral sclerosis patients without ophthalmic disease.” Plos One 12, no. 9 (2017): e0185242. https://doi.org/10.1371/journal.pone.0185242.
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  - McNabb, Ryan P., Tomas Blanco, Howard M. Bomze, Henry C. Tseng, Daniel R. Saban, Joseph A. Izatt, and Anthony N. Kuo. “Method for single illumination source combined optical coherence tomography and fluorescence imaging of fluorescently labeled ocular structures in transgenic mice.” Exp Eye Res 151 (October 2016): 68–74. https://doi.org/10.1016/j.exer.2016.08.003.
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  - Mendel, Thomas, David Fleischman, R Rand Allingham, Henry Tseng, and David A. Chesnutt. “Spectrum and Clinical Course of Visual Field Abnormalities in Ethambutol Toxicity.” Neuroophthalmology 40, no. 3 (June 2016): 139–45. https://doi.org/10.3109/01658107.2016.1173065.
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  - Tseng, Henry C., Thorfinn T. Riday, Celia McKee, Catherine E. Braine, Howard Bomze, Ian Barak, Carrie Marean-Reardon, Simon W. M. John, Benjamin D. Philpot, and Michael D. Ehlers. “Visual impairment in an optineurin mouse model of primary open-angle glaucoma.” Neurobiol Aging 36, no. 6 (June 2015): 2201–12. https://doi.org/10.1016/j.neurobiolaging.2015.02.012.
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  - Lee, Dong Joon, Henry C. Tseng, Sing Wai Wong, Zhengyan Wang, Meng Deng, and Ching-Chang Ko. “Dopaminergic effects on in vitro osteogenesis.” Bone Res 3 (2015): 15020. https://doi.org/10.1038/boneres.2015.20.
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  - Muir, Kelly W., Annie Lim, Sandra Stinnett, Anthony Kuo, Henry Tseng, and Molly M. Walsh. “Risk factors for exposure of glaucoma drainage devices: a retrospective observational study.” Bmj Open 4, no. 5 (May 2, 2014): e004560. https://doi.org/10.1136/bmjopen-2013-004560.
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  - Tseng, Henry C., Stephan J. Ruegg, Margaret Maronski, Conrad A. Messam, Judith B. Grinspan, and Marc A. Dichter. “Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture.” Neurobiol Dis 22, no. 1 (April 2006): 88–97. https://doi.org/10.1016/j.nbd.2005.10.007.
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  - Chen, Jinqiu, Henry C. Tseng, Marc A. Dichter, Hongtao Zhang, and Mark I. Greene. “Differential localization of ErbB receptor ensembles influences their signaling in hippocampal neurons.” Dna Cell Biol 24, no. 9 (September 2005): 553–62. https://doi.org/10.1089/dna.2005.24.553.
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  - Tseng, Henry C., and Marc A. Dichter. “Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons.” Neurobiol Dis 19, no. 1–2 (2005): 77–83. https://doi.org/10.1016/j.nbd.2004.11.007.
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  - Telfeian, Albert E., Henry C. Tseng, Marianna Baybis, Peter B. Crino, and Marc A. Dichter. “Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons.” Epilepsia 44, no. 2 (February 2003): 143–49. https://doi.org/10.1046/j.1528-1157.2003.06102.x.
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  - Tseng, H. C., R. Dadoo, and R. N. Zare. “Selective determination of adenine-containing compounds by capillary electrophoresis with laser-induced fluorescence detection.” Analalytical Biochemistry 222, no. 1 (October 1994): 55–58. https://doi.org/10.1006/abio.1994.1453.
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- Book Sections
  - Ko, C. C., Z. Wang, H. Tseng, D. J. Lee, and C. Guez. “Design, synthesis, and evaluation of polydopamine-laced gelatinous hydroxyapatite nanocomposites for orthopedic applications.” In Advances in Bioceramics and Biotechnologies II, 135–48, 2014. https://doi.org/10.1002/9781118771587.ch13.
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  - Ko, C. C., C. Guez, D. J. Lee, Z. Wang, and H. Tseng. “Design, synthesis, and evaluation of polydopamine-laced gelatinous hydroxyapatite nanocomposites for orthopedic applications,” 247:135–48, 2014. https://doi.org/10.1002/9781118771587.ch13.
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- Conference Papers
  - Fricks, R. W. B., H. H. Tseng, M. Pajic, and K. S. Trivedi. “Transient performance & availability modeling in high volume outpatient clinics.” In Proceedings Annual Reliability and Maintainability Symposium, 2017. https://doi.org/10.1109/RAM.2017.7889777.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Previous Appointments & Affiliations

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses