Herbert Pang | Scholars@Duke

Herbert Pang
Adjunct Assistant Professor in the Department of Biostatistics and Bioinformatics

Classification and Predictive Models
Design and Analysis of Biomarker Clinical Trials
Genomics
Pathway Analysis

Current Appointments & Affiliations

Adjunct Assistant Professor in the Department of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2013

Contact Information

2424 Erwin Road Ste 1102, 11107 Hock Plaza, Durham, NC 27705
Duke Box 2721, Durham, NC 27710
herbert.pang@duke.edu (919) 681-8830

Background
Education, Training, & Certifications
- Ph.D., Yale University 2008
Duke Appointment History
- Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2008 - 2013
Expertise
Subject Headings
Research
Selected Grants
- Characterizing Alcohol's Effects on Repair of Liver Injury awarded by National Institutes of Health 2009 - 2012
- Anti-VEGF in Tumors & Wounds: Efficacy vs Toxicity awarded by National Institutes of Health 2006 - 2012
Publications & Artistic Works
Selected Publications
- Book Sections
  - Pang, H, Kim, I, and Zhao, H. "Pathway-Based Methods for Analyzing Microarray Data." In Analysis of Microarray Data: A Network-Based Approach, 355-384. September 16, 2008. Full Text
  - George, , Wang, , and Pang, . "Endpoints for cancer clinical trials." In Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis, edited by George, 3-36. Chapman & Hall/CRC. (Chapter)
- Conference Papers
  - Pang, H, Stinchcombe, T, Cheng, P, Lee, AW, Lee, VH, Vokes, EE, and Wang, X. "Comparison of chemoradiotherapy treatment strategies in stage III non-small cell lung cancer among elderly patients from multiple data sources." April 2017. Link to Item
  - Wang, X, Lian, H, Nwogu, C, D’Cunha, J, and Pang, H. "P0124 Short-term and long-term outcomes for video-assisted thoracoscopic surgery and open lobectomy: Results from statistical analysis adjusting for treatment selection bias." July 2015. Full Text
  - Clarke, JM, Pang, H, Starr, MD, Hatch, AJ, Kindler, HL, O'Reilly, EM, Innocenti, F, Venook, AP, Hurwitz, H, and Nixon, AB. "Coagulation factors in citrated plasma predict for benefit from bevacizumab (B) in patients with advanced pancreatic cancer (APC): Results from CALGB 80303 (Alliance)." January 20, 2015. Full Text
  - Hatch, AJ, Pang, H, Starr, MD, Brady, JC, Jia, J, Jiang, C, Sibley, A, Owzar, K, Niedzwiecki, D, Venook, AP, Cushman, SM, Hurwitz, H, and Nixon, AB. "Prognostic and predictive blood-based biomarkers of overall survival (OS) in patients (pts) with advanced colorectal cancer (CRC) treated with cetuximab (C): Results from CALGB 80203 (Alliance)." May 20, 2014. Link to Item
  - Liu, Y, Clarke, JM, Starr, MD, Brady, JC, Pang, H, Rushing, C, Alvarez, D, Adams, BJ, Theuer, CP, Hurwitz, H, and Nixon, AB. "Biomarker modulation in patients (pts) receiving TRC105 (T) and bevacizumab (B) in a phase Ib clinical trial." May 20, 2014. Link to Item
  - Hatch, AJ, Pang, H, Starr, MD, Brady, JC, Jia, J, Niedzwiecki, D, Venook, AP, Cushman, SM, Hurwitz, H, and Nixon, AB. "Prognostic and predictive blood-based biomarkers of overall survival (OS) in patients (pts) with advanced colorectal cancer (CRC) treated with cetuximab (C): Results from CALGB 80203 (Alliance)." January 20, 2014. Full Text
  - Bohinc, B, Michelotti, GA, Xie, G, Pang, H, Suzuki, A, Guy, CD, Piercy, DL, Kruger, L, Swiderska-Syn, M, Machado, MV, Pereira, TA, Zavacki, AM, Abdelmalek, MF, and Diehl, AM. "Repair-related Activation of Hedgehog Signaling in Stromal Cells Promotes Intrahepatic Hypothyroidism." 2014. Link to Item
  - Strickler, JH, McCall, S, Nixon, AB, Pang, H, Rushing, C, Arrowood, C, Haley, S, Meadows, K, and Hurwitz, H. "Correlation of Src activation with response to dasatinib, capecitabine, oxaliplatin, and bevacizumab in advanced solid tumors." May 20, 2013. Link to Item
  - Pang, H, Gu, L, Richards, W, Crawford, J, Green, M, Vokes, E, and Wang, X. "Abstract 4707: Validation of survival prognostic models for non-small-cell lung cancer instage- and age-specific groups." April 15, 2013. Full Text
  - Garrett, ME, Moylan, CA, Gibson, J, Yang, H, Pang, H, Dellinger, A, Suzuki, A, Tillmann, HL, Guy, CD, Abdelmalek, MF, Murphy, SK, Diehl, AM, Hauser, M, and Ashley-Koch, AE. "Expression QTL analysis of a gene expression signature which predicts advanced non-alcoholic fatty liver disease." October 2012. Link to Item
  - Suzuki, A, Guy, CD, Pang, H, Smith, AD, Diehl, AM, and Abdelmalek, MF. "Impact of Gender and Menopause on Histologic Severity of Inflammation and Injury in patients with Nonalcoholic Fatty Liver Disease." October 2012. Link to Item
  - Suzuki, A, Pang, H, Guy, CD, Smith, AD, Diehl, AM, and Abdelmalek, MF. "Gender and Menopause Impact Severity of Fibrosis among Patients with Nonalcoholic Steatohepatitis." October 2012. Link to Item
  - Smith, EML, Pang, H, Cirrincione, C, Fleishman, SB, Paskett, ED, Fadul, CE, Knox, C, Shapiro, CL, Gilman, P, and Canc, LGB. "CALGB 170601: A phase III double blind trial of duloxetine to treat painful chemotherapy-induced peripheral neuropathy (CIPN)." June 20, 2012. Link to Item
  - Jia, J, Li, H, Dellinger, A, Pang, H, Russell, KB, Hurwitz, H, and Nixon, AB. "Modulation of pharmacodynamic (PD) biomarkers in dermal biopsies from patients treated on a phase I study of bevacizumab (Bev) in combination with everolimus (Ev) and erlotinib (Erl) for advanced solid tumors." May 20, 2012. Link to Item
  - Liu, Y, Starr, M, Brady, JC, Pang, H, Dellinger, A, Leigh, BR, Theuer, CP, Hurwitz, H, and Nixon, AB. "Modulation of angiogenic biomarkers in patients receiving high-dose TRC105." May 20, 2012. Link to Item
  - Smith, EML, Pang, H, Cirrincione, C, Fleishman, SB, Paskett, ED, Fadul, CE, Knox, C, Shapiro, CL, Gilman, P, and Canc, LGB. "CALGB 170601: A phase III double blind trial of duloxetine to treat painful chemotherapy-induced peripheral neuropathy (CIPN)." May 20, 2012. Full Text Link to Item
  - Tillmann, H, Suzuki, A, Pang, H, Dellinger, A, Guy, CD, Moylan, CA, Piercy, D, Smith, M, Hauser, MA, Diehl, AME, and Abdelmalek, MF. "COFFEE CONSUMPTION INCREASES HEPATIC EXPRESSION OF CYTOCHROME P450S AND SIGNIFICANTLY REDUCES LIVER FIBROSIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE (NAFLD)." March 2011. Full Text Link to Item
- Journal Articles
  - Yan, KK, Zhao, H, and Pang, H. "A comparison of graph- and kernel-based -omics data integration algorithms for classifying complex traits." BMC bioinformatics 18, no. 1 (December 6, 2017): 539-. Full Text
  - Han, L, Lee, C-K, Pang, H, Chan, H-T, Lo, I-L, Lam, S-K, Cheong, T-H, and Ho, JC-M. "Genetic predisposition to lung adenocarcinoma among never-smoking Chinese with different epidermal growth factor receptor mutation status." Lung cancer (Amsterdam, Netherlands) 114 (December 2017): 79-89. Full Text
  - Leung, KC, Mui, C, Chiu, WY, Ng, YY, Chen, MHY, Ho, PH, Kwok, CP, Lam, SSM, Wong, CY, Wong, KY, and Pang, HH. "Impact of patient education on influenza vaccine uptake among community-dwelling elderly: a randomized controlled trial." Health Education Research 32, no. 5 (October 1, 2017): 455-464. Full Text
  - Stinchcombe, TE, Zhang, Y, Vokes, EE, Schiller, JH, Bradley, JD, Kelly, K, Curran, WJ, Schild, SE, Movsas, B, Clamon, G, Govindan, R, Blumenschein, GR, Socinski, MA, Ready, NE, Akerley, WL, Cohen, HJ, Pang, HH, and Wang, X. "Pooled Analysis of Individual Patient Data on Concurrent Chemoradiotherapy for Stage III Non-Small-Cell Lung Cancer in Elderly Patients Compared With Younger Patients Who Participated in US National Cancer Institute Cooperative Group Studies." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 35, no. 25 (September 2017): 2885-2892. Full Text
  - Yao, XI, Wang, X, Speicher, PJ, Hwang, ES, Cheng, P, Harpole, DH, Berry, MF, Schrag, D, and Pang, HH. "Reporting and Guidelines in Propensity Score Analysis: A Systematic Review of Cancer and Cancer Surgical Studies." JNCI Journal of the National Cancer Institute 109, no. 8 (August 2017). (Review) Full Text
  - Quan, J, Li, TK, Pang, H, Choi, CH, Siu, SC, Tang, SY, Wat, NMS, Woo, J, Johnston, JM, and Leung, GM. "Diabetes incidence and prevalence in Hong Kong, China during 2006-2014." Diabetic Medicine 34, no. 7 (July 2017): 902-908. Full Text
  - Ni, MY, Li, TK, Pang, H, Chan, BHY, Kawachi, I, Viswanath, K, Schooling, CM, and Leung, GM. "Longitudinal Patterns and Predictors of Depression Trajectories Related to the 2014 Occupy Central/Umbrella Movement in Hong Kong." American journal of public health 107, no. 4 (April 2017): 593-600. Full Text
  - Smith, EML, Pang, H, Ye, C, Cirrincione, C, Fleishman, S, Paskett, ED, Ahles, T, Bressler, LR, Le-Lindqwister, N, Fadul, CE, Loprinzi, C, Shapiro, CL, and Alliance for Clinical Trials in Oncology, . "Predictors of duloxetine response in patients with oxaliplatin-induced painful chemotherapy-induced peripheral neuropathy (CIPN): a secondary analysis of randomised controlled trial - CALGB/alliance 170601." European journal of cancer care 26, no. 2 (March 2017). Full Text
  - Wang, X, Wang, X, Hodgson, L, George, SL, Sargent, DJ, Foster, NR, Ganti, AK, Stinchcombe, TE, Crawford, J, Kratzke, R, Adjei, AA, Kindler, HL, Vokes, EE, and Pang, H. "Validation of Progression-Free Survival as a Surrogate Endpoint for Overall Survival in Malignant Mesothelioma: Analysis of Cancer and Leukemia Group B and North Central Cancer Treatment Group (Alliance) Trials." The oncologist 22, no. 2 (February 10, 2017): 189-198. Full Text
  - Cheng, L, Kim, I, and Pang, H. "Bayesian Semiparametric Model for Pathway-Based Analysis with Zero-Inflated Clinical Outcomes." Journal of Agricultural, Biological and Environmental Statistics 21, no. 4 (December 2016): 641-662. Full Text
  - Kuang, Y-S, Li, S-H, Guo, Y, Lu, J-H, He, J-R, Luo, B-J, Jiang, F-J, Shen, H, Papasian, CJ, Pang, H, Xia, H-M, Deng, H-W, and Qiu, X. "Composition of gut microbiota in infants in China and global comparison." Scientific Reports 6, no. 1 (December 2016). Full Text
  - Ni, MY, Li, TK, Pang, H, Chan, BHY, Yuan, BY, Kawachi, I, Schooling, CM, and Leung, GM. "Direct Participation in and Indirect Exposure to the Occupy Central Movement and Depressive Symptoms: A Longitudinal Study of Hong Kong Adults." American journal of epidemiology 184, no. 9 (November 2016): 636-643. Full Text
  - Pang, HH, Wang, X, Stinchcombe, TE, Wong, ML, Cheng, P, Ganti, AK, Sargent, DJ, Zhang, Y, Hu, C, Mandrekar, SJ, Redman, MW, Manola, JB, Schilsky, RL, Cohen, HJ, Bradley, JD, Adjei, AA, Gandara, D, Ramalingam, SS, and Vokes, EE. "Enrollment Trends and Disparity Among Patients With Lung Cancer in National Clinical Trials, 1990 to 2012." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 34, no. 33 (November 2016): 3992-3999. Full Text
  - Hatch, AJ, Sibley, AB, Starr, MD, Brady, JC, Jiang, C, Jia, J, Bowers, DL, Pang, H, Owzar, K, Niedzwiecki, D, Innocenti, F, Venook, AP, Hurwitz, HI, Nixon, AB, and Alliance for Clinical Trials in Oncology, . "Blood-based markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance)." Cancer medicine 5, no. 9 (September 2016): 2249-2260. Full Text
  - Salama, JK, Gu, L, Wang, X, Pang, HH, Bogart, JA, Crawford, J, Schild, SE, Vokes, EE, and Ready, NE. "Positive Interaction between Prophylactic Cranial Irradiation and Maintenance Sunitinib for Untreated Extensive-Stage Small Cell Lung Cancer Patients After Standard Chemotherapy: A Secondary Analysis of CALGB 30504 (ALLIANCE)." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 11, no. 3 (March 2016): 361-369. Full Text
  - Pang, H, and Wang, X. "Statistical aspect of translational and correlative studies in clinical trials." Chinese clinical oncology 5, no. 1 (February 2016): 11-. Full Text
  - Dong, K, Pang, H, Tong, T, and Genton, MG. "Shrinkage-based diagonal Hotelling’s tests for high-dimensional small sample size data." Journal of Multivariate Analysis 143 (January 2016): 127-142. Full Text
  - Ni, MY, Li, TK, Yu, NX, Pang, H, Chan, BHY, Leung, GM, and Stewart, SM. "Normative data and psychometric properties of the Connor-Davidson Resilience Scale (CD-RISC) and the abbreviated version (CD-RISC2) among the general population in Hong Kong." Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 25, no. 1 (January 2016): 111-116. Full Text
  - Yuan, J, Pang, H, Tong, T, Xi, D, Guo, W, and Mesenbrink, P. "Seamless Phase IIa/IIb and enhanced dose-finding adaptive design." Journal of biopharmaceutical statistics 26, no. 5 (January 2016): 912-923. Full Text
  - Wang, X, Gu, L, Zhang, Y, Sargent, DJ, Richards, W, Ganti, AK, Crawford, J, Cohen, HJ, Stinchcombe, T, Vokes, E, and Pang, H. "Validation of survival prognostic models for non-small-cell lung cancer in stage- and age-specific groups." Lung cancer (Amsterdam, Netherlands) 90, no. 2 (November 2015): 281-287. Full Text
  - Pang, H, Kim, I, and Zhao, H. "Random Effects Model for Multiple Pathway Analysis with Applications to Type II Diabetes Microarray Data." Statistics in biosciences 7, no. 2 (October 2015): 167-186. Full Text
  - Jia, J, Dellinger, AE, Weiss, ES, Bulusu, A, Rushing, C, Li, H, Howard, LA, Kaplan, N, Pang, H, Hurwitz, HI, and Nixon, AB. "Direct Evidence of Target Inhibition with Anti-VEGF, EGFR, and mTOR Therapies in a Clinical Model of Wound Healing." Clinical cancer research : an official journal of the American Association for Cancer Research 21, no. 15 (August 2015): 3442-3452. Full Text
  - Ready, NE, Pang, HH, Gu, L, Otterson, GA, Thomas, SP, Miller, AA, Baggstrom, M, Masters, GA, Graziano, SL, Crawford, J, Bogart, J, and Vokes, EE. "Chemotherapy With or Without Maintenance Sunitinib for Untreated Extensive-Stage Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase II Study-CALGB 30504 (Alliance)." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 33, no. 15 (May 2015): 1660-1665. Full Text
  - Liu, Y, Starr, MD, Brady, JC, Rushing, C, Bulusu, A, Pang, H, Honeycutt, W, Amara, A, Altomare, I, Uronis, HE, Hurwitz, HI, and Nixon, AB. "Biomarker signatures correlate with clinical outcome in refractory metastatic colorectal cancer patients receiving bevacizumab and everolimus." Molecular cancer therapeutics 14, no. 4 (April 2015): 1048-1056. Full Text
  - Nwogu, CE, D'Cunha, J, Pang, H, Gu, L, Wang, X, Richards, WG, Veit, LJ, Demmy, TL, Sugarbaker, DJ, Kohman, LJ, Swanson, SJ, and Alliance for Clinical Trials in Oncology, . "VATS lobectomy has better perioperative outcomes than open lobectomy: CALGB 31001, an ancillary analysis of CALGB 140202 (Alliance)." The Annals of thoracic surgery 99, no. 2 (February 2015): 399-405. Full Text
  - Rushing, C, Bulusu, A, Hurwitz, HI, Nixon, AB, and Pang, H. "A leave-one-out cross-validation SAS macro for the identification of markers associated with survival." Computers in biology and medicine 57 (February 2015): 123-129. Full Text
  - Uronis, HE, Jia, J, Bendell, JC, Howard, L, Ready, NA, Lee, PH, Starr, MD, Dellinger, A, Pang, H, Nixon, AB, and Hurwitz, HI. "A Phase I/biomarker study of bevacizumab in combination with CNTO 95 in patients with advanced solid tumors." Cancer chemotherapy and pharmacology 75, no. 2 (February 2015): 343-352. Full Text
  - Nwogu, CE, D'Cunha, J, Pang, H, Gu, L, Wang, X, Richards, WG, Veit, LJ, Demmy, TL, Sugarbaker, DJ, Kohman, LJ, and Swanson, SJ. "VATS lobectomy has better perioperative outcomes than open lobectomy: CALGB 31001, an ancillary analysis of CALGB 140202 (Alliance)." Annals of Thoracic Surgery 99, no. 2 (January 1, 2015): 399-405. Full Text
  - Uronis, HE, Jia, J, Bendell, JC, Howard, L, Ready, NA, Lee, PH, Starr, MD, Dellinger, A, Pang, H, Nixon, AB, and Hurwitz, HI. "A Phase I/biomarker study of bevacizumab in combination with CNTO 95 in patients with advanced solid tumors." Cancer Chemotherapy and Pharmacology 75, no. 2 (January 1, 2015): 343-352. Full Text
  - Bohinc, BN, Michelotti, G, Xie, G, Pang, H, Suzuki, A, Guy, CD, Piercy, D, Kruger, L, Swiderska-Syn, M, Machado, M, Pereira, T, Zavacki, AM, Abdelmalek, M, and Diehl, AM. "Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism." Endocrinology 155, no. 11 (November 2014): 4591-4601. Full Text
  - Moylan, CA, Pang, H, Michelotti, G, and Diehl, AM. "Reply." Hepatology 60, no. 4 (October 2014): 1445-1446. Full Text
  - Moylan, CA, Pang, H, Michelotti, G, and Diehl, AM. "Reply: To PMID 23913408." Hepatology (Baltimore, Md.) 60, no. 4 (October 2014): 1445-1446. (Letter) Full Text
  - Rangwala, F, Bendell, JC, Kozloff, MF, Arrowood, CC, Dellinger, A, Meadows, J, Tourt-Uhlig, S, Murphy, J, Meadows, KL, Starr, A, Broderick, S, Brady, JC, Cushman, SM, Morse, MA, Uronis, HE, Hsu, SD, Zafar, SY, Wallace, J, Starodub, AN, Strickler, JH, Pang, H, Nixon, AB, and Hurwitz, HI. "Phase I study of capecitabine, oxaliplatin, bevacizumab, and everolimus in advanced solid tumors." Investigational new drugs 32, no. 4 (August 2014): 700-709. Full Text
  - Dellinger, AE, Nixon, AB, and Pang, H. "Integrative pathway analysis using Graph-Based learning with applications to TCGA colon and ovarian data." Cancer Informatics 13, no. SUPPL.4 (July 28, 2014). Full Text
  - Liu, Y, Starr, MD, Brady, JC, Dellinger, A, Pang, H, Adams, B, Theuer, CP, Lee, NY, Hurwitz, HI, and Nixon, AB. "Modulation of circulating protein biomarkers following TRC105 (anti-endoglin antibody) treatment in patients with advanced cancer." Cancer medicine 3, no. 3 (June 2014): 580-591. Full Text
  - Strickler, JH, McCall, S, Nixon, AB, Brady, JC, Pang, H, Rushing, C, Cohn, A, Starodub, A, Arrowood, C, Haley, S, Meadows, KL, Morse, MA, Uronis, HE, Blobe, GC, Hsu, SD, Zafar, SY, and Hurwitz, HI. "Phase I study of dasatinib in combination with capecitabine, oxaliplatin and bevacizumab followed by an expanded cohort in previously untreated metastatic colorectal cancer." Invest New Drugs 32, no. 2 (April 2014): 330-339. Full Text Link to Item
  - Cirrincione, CT, Lavoie Smith, EM, and Pang, H. "Methodological considerations in the design and implementation of clinical trials." Seminars in oncology nursing 30, no. 1 (February 2014): 74-79. Full Text
  - Moylan, CA, Pang, H, Dellinger, A, Suzuki, A, Garrett, ME, Guy, CD, Murphy, SK, Ashley-Koch, AE, Choi, SS, Michelotti, GA, Hampton, DD, Chen, Y, Tillmann, HL, Hauser, MA, Abdelmalek, MF, and Diehl, AM. "Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease." Hepatology 59, no. 2 (February 2014): 471-482. Full Text Link to Item
  - Dellinger, AE, Nixon, AB, and Pang, H. "Integrative Pathway Analysis Using Graph-Based Learning with Applications to TCGA Colon and Ovarian Data." Cancer informatics 13, no. Suppl 4 (January 2014): 1-9. Full Text
  - Ni, MY, Chan, BHY, Leung, GM, Lau, EHY, and Pang, H. "Transmissibility of the Ice Bucket Challenge among globally influential celebrities: retrospective cohort study." BMJ (Clinical research ed.) 349 (January 2014): g7185-. Full Text
  - Pang, H, and Zhao, H. "Stratified pathway analysis to identify gene sets associated with oral contraceptive use and breast cancer." Cancer informatics 13, no. Suppl 4 (January 2014): 73-78. Full Text
  - Rangwala, F, Bendell, JC, Kozloff, MF, Arrowood, CC, Dellinger, A, Meadows, J, Tourt-Uhlig, S, Murphy, J, Meadows, KL, Starr, A, Broderick, S, Brady, JC, Cushman, SM, Morse, MA, Uronis, HE, Hsu, SD, Zafar, SY, Wallace, J, Starodub, AN, Strickler, JH, Pang, H, Nixon, AB, and Hurwitz, HI. "Phase I study of capecitabine, oxaliplatin, bevacizumab, and everolimus in advanced solid tumors." Investigational New Drugs 32, no. 4 (January 1, 2014): 700-709. Full Text
  - Strickler, JH, McCall, S, Nixon, AB, Brady, JC, Pang, H, Rushing, C, Cohn, A, Starodub, A, Arrowood, C, Haley, S, Meadows, KL, Morse, MA, Uronis, HE, Blobe, GC, Hsu, SD, Zafar, SY, and Hurwitz, HI. "Phase i study of dasatinib in combination with capecitabine, oxaliplatin and bevacizumab followed by an expanded cohort in previously untreated metastatic colorectal cancer." Investigational New Drugs 32, no. 2 (January 1, 2014): 330-339. Full Text
  - Yang, JD, Abdelmalek, MF, Pang, H, Guy, CD, Smith, AD, Diehl, AM, and Suzuki, A. "Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis." Hepatology 59, no. 4 (January 1, 2014): 1406-1414. Full Text
  - Nixon, AB, Pang, H, Starr, MD, Friedman, PN, Bertagnolli, MM, Kindler, HL, Goldberg, RM, Venook, AP, Hurwitz, HI, and Alliance for Clinical Trials In Oncology, . "Prognostic and predictive blood-based biomarkers in patients with advanced pancreatic cancer: results from CALGB80303 (Alliance)." Clin Cancer Res 19, no. 24 (December 15, 2013): 6957-6966. Full Text Link to Item
  - Salama, JK, Pang, H, Bogart, JA, Blackstock, AW, Urbanic, JJ, Hodgson, L, Crawford, J, and Vokes, EE. "Predictors of pulmonary toxicity in limited stage small cell lung cancer patients treated with induction chemotherapy followed by concurrent platinum-based chemotherapy and 70Gy daily radiotherapy: CALGB 30904." Lung Cancer 82, no. 3 (December 1, 2013): 436-440. Full Text
  - Murphy, SK, Yang, H, Moylan, CA, Pang, H, Dellinger, A, Abdelmalek, MF, Garrett, ME, Ashley-Koch, A, Suzuki, A, Tillmann, HL, Hauser, MA, and Diehl, AM. "Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease." Gastroenterology 145, no. 5 (November 2013): 1076-1087. Full Text Link to Item
  - Salama, JK, Hodgson, L, Pang, H, Urbanic, JJ, Blackstock, AW, Schild, SE, Crawford, J, Bogart, JA, Vokes, EE, and Cancer and Leukemia Group B, . "A pooled analysis of limited-stage small-cell lung cancer patients treated with induction chemotherapy followed by concurrent platinum-based chemotherapy and 70 Gy daily radiotherapy: CALGB 30904." J Thorac Oncol 8, no. 8 (August 2013): 1043-1049. Full Text Link to Item
  - Uronis, HE, Cushman, SM, Bendell, JC, Blobe, GC, Morse, MA, Nixon, AB, Dellinger, A, Starr, MD, Li, H, Meadows, K, Gockerman, J, Pang, H, and Hurwitz, HI. "A phase I study of ABT-510 plus bevacizumab in advanced solid tumors." Cancer Med 2, no. 3 (June 2013): 316-324. Full Text Open Access Copy Link to Item
  - Smith, EML, Pang, H, Cirrincione, C, Fleishman, S, Paskett, ED, Ahles, T, Bressler, LR, Fadul, CE, Knox, C, Le-Lindqwister, N, Gilman, PB, Shapiro, CL, and Oncology, ACT. "Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy A Randomized Clinical Trial." JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 309, no. 13 (April 3, 2013): 1359-1367. Full Text Link to Item
  - Liu, Y, Starr, MD, Bulusu, A, Pang, H, Wong, NS, Honeycutt, W, Amara, A, Hurwitz, HI, and Nixon, AB. "Correlation of angiogenic biomarker signatures with clinical outcomes in metastatic colorectal cancer patients receiving capecitabine, oxaliplatin, and bevacizumab." Cancer Med 2, no. 2 (April 2013): 234-242. Full Text Link to Item
  - Pang, H, and Jung, S-H. "Sample size considerations of prediction-validation methods in high-dimensional data for survival outcomes." Genet Epidemiol 37, no. 3 (April 2013): 276-282. Full Text Link to Item
  - Balajonda, N, Bisanar, TL, Mathew, JP, Pang, H, and Voils, CI. "Determinants of a subject's decision to participate in clinical anesthesia research." Anesth Analg 116, no. 2 (February 2013): 448-454. Full Text Link to Item
  - Garrett, ME, Abdelmalek, MF, Ashley-Koch, A, Hauser, MA, Moylan, CA, Pang, H, Diehl, AM, and Tillmann, HL. "IL28B rs12979860 is not associated with histologic features of NAFLD in a cohort of Caucasian North American patients." J Hepatol 58, no. 2 (February 2013): 402-403. (Letter) Full Text Link to Item
  - Balajonda, N, Bisanar, TL, Mathew, JP, Pang, H, and Voils, CI. "Determinants of a subject's decision to participate in clinical anesthesia research." Anesthesia and Analgesia 116, no. 2 (2013): 448-454. Full Text
  - Garrett, ME, Abdelmalek, MF, Ashley-Koch, A, Hauser, MA, Moylan, CA, Pang, H, Diehl, AM, and Tillmann, HL. "IL28B rs12979860 is not associated with histologic features of NAFLD in a cohort of Caucasian North American patients." Journal of Hepatology 58, no. 2 (2013): 402-403. Full Text
  - Kelley, MJ, Bogart, JA, Hodgson, LD, Ansari, RH, Atkins, JN, Pang, H, Green, MR, and Vokes, EE. "Phase II study of induction cisplatin and irinotecan followed by concurrent carboplatin, etoposide, and thoracic radiotherapy for limited-stage small-cell lung cancer, CALGB 30206." J Thorac Oncol 8, no. 1 (January 2013): 102-108. Full Text Link to Item
  - Kelley, MJ, Bogart, JA, Hodgson, LD, Ansari, RH, Atkins, JN, Pang, H, Green, MR, and Vokes, EE. "Phase II study of induction cisplatin and irinotecan followed by concurrent carboplatin, etoposide, and thoracic radiotherapy for limited-stage small-cell lung cancer, CALGB 30206." Journal of Thoracic Oncology 8, no. 1 (2013): 102-108. Full Text
  - Kim, I, Pang, H, and Zhao, H. "Statistical properties on semiparametric regression for evaluating pathway effects." Journal of Statistical Planning and Inference 143, no. 4 (2013): 745-763. Full Text
  - Mauguen, A, Pignon, J-P, Burdett, S, Domerg, C, Fisher, D, Paulus, R, Mandrekar, SJ, Belani, CP, Shepherd, FA, Eisen, T, Pang, H, Collette, L, Sause, WT, Dahlberg, SE, Crawford, J, O'Brien, M, Schild, SE, Parmar, M, Tierney, JF, Pechoux, CL, and Michiels, S. "Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: A re-analysis of meta-analyses of individual patients' data." The Lancet Oncology 14, no. 7 (2013): 619-626. Full Text
  - Mauguen, A, Pignon, J-P, Burdett, S, Domerg, C, Fisher, D, Paulus, R, Mandrekar, SJ, Belani, CP, Shepherd, FA, Eisen, T, and al, E. "Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients' data." The Lancet Oncology (2013). Full Text
  - Pang, H, Tong, T, and Ng, M. "Block-diagonal discriminant analysis and its bias-corrected rules." STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY 12, no. 3 (2013): 347-359. Full Text Link to Item
  - Pang, H, and Jung, S-H. "Sample size considerations of prediction-validation methods in high-dimensional data for survival outcomes." Genetic Epidemiology 37, no. 3 (2013): 276-282. Full Text
  - Salama, JK, Hodgson, L, Pang, H, Urbanic, JJ, Blackstock, AW, Schild, SE, Crawford, J, Bogart, JA, and Vokes, EE. "A pooled analysis of limited-stage small-cell lung cancer patients treated with induction chemotherapy followed by concurrent platinum-based chemotherapy and 70 Gy daily radiotherapy: CALGB 30904." Journal of Thoracic Oncology 8, no. 8 (2013): 1043-1049. Full Text
  - Salama, JK, Pang, H, Bogart, JA, Blackstock, AW, Urbanic, JJ, Hodgson, L, Crawford, J, and Vokes, EE. "Predictors of pulmonary toxicity in limited stage small cell lung cancer patients treated with induction chemotherapy followed by concurrent platinum-based chemotherapy and 70 Gy daily radiotherapy: CALGB 30904." Lung Cancer (2013).
  - Smith, EML, and Pang, H. "Therapy for chemotherapy-induced peripheral neuropathy - In reply." JAMA - Journal of the American Medical Association 310, no. 5 (2013): 538--. Full Text
  - Uronis, HE, Bendell, JC, Altomare, I, Blobe, GC, Hsu, SD, Morse, MA, Pang, H, Zafar, SY, Conkling, P, Favaro, J, Arrowood, CC, Cushman, SM, Meadows, KL, Brady, JC, Nixon, AB, and Hurwitz, HI. "A phase II study of capecitabine, oxaliplatin, and bevacizumab in the treatment of metastatic esophagogastric adenocarcinomas." Oncologist 18, no. 3 (2013): 271-272. Full Text Link to Item
  - Bohinc, B, Suzuki, A, Guy, C, Pang, H, Piercy, D, Feinglos, M, Yen, P, Diehl, AM, and Abdelmalek, M. "The Association of Serum Thyroid Hormone Levels and Hepatic Gene Expression of Potential Regulators of Intracellular Thyroid Hormone Concentration with Severity of Nonalcoholic Fatty Liver Disease." AMERICAN JOURNAL OF GASTROENTEROLOGY 107 (October 2012): S193-S193. Link to Item
  - Pang, H, George, SL, Hui, K, and Tong, T. "Gene selection using iterative feature elimination random forests for survival outcomes." IEEE/ACM Trans Comput Biol Bioinform 9, no. 5 (September 2012): 1422-1431. Full Text Open Access Copy Link to Item
  - Salgia, R, Nallasura, V, Pang, H, Rolle, CE, Richards, W, Hodgson, L, Arif, Q, Husain, A, Kratzke, R, and Vokes, EE. "An Interim Report Of CALGB 150607: Expression And Mutational Status Of c-MET, HGF, EGFR, KRAS, p53, c-CBL, And E-cadherin In Resected Lung Adenocarcinoma Specimens." JOURNAL OF THORACIC ONCOLOGY 7, no. 9 (September 2012): S245-S246. Link to Item
  - Syn, W-K, Agboola, KM, Swiderska, M, Michelotti, GA, Liaskou, E, Pang, H, Xie, G, Philips, G, Chan, IS, Karaca, GF, Pereira, TDA, Chen, Y, Mi, Z, Kuo, PC, Choi, SS, Guy, CD, Abdelmalek, MF, and Diehl, AM. "NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease." Gut 61, no. 9 (September 2012): 1323-1329. Full Text Link to Item
  - Kim, I, Pang, H, and Zhao, H. "Bayesian semiparametric regression models for evaluating pathway effects on continuous and binary clinical outcomes." Stat Med 31, no. 15 (July 10, 2012): 1633-1651. Full Text Link to Item
  - Dudek, AZ, Pang, H, Kratzke, RA, Otterson, GA, Hodgson, L, Vokes, EE, Kindler, HL, and Cancer and Leukemia Group B, . "Phase II study of dasatinib in patients with previously treated malignant mesothelioma (cancer and leukemia group B 30601): a brief report." J Thorac Oncol 7, no. 4 (April 2012): 755-759. Full Text Link to Item
  - Kong, TSK, Laidler, KJ, and Pang, H. "Relationship type, condom use and HIV/AIDS risks among men who have sex with men in six Chinese cities." AIDS Care 24, no. 4 (2012): 517-528. Full Text Link to Item
  - Syn, W-K, Agboola, KM, Swiderska, M, Michelotti, GA, Liaskou, E, Pang, H, Xie, G, Philips, G, Chan, IS, Karaca, GF, Pereira, TDA, Chen, Y, Mi, Z, Kuo, PC, Choi, SS, Guy, CD, Abdelmalek, MF, and Diehl, AM. "NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease." Gut (2012). Full Text
  - Ready, NE, Dudek, AZ, Pang, HH, Hodgson, LD, Graziano, SL, Green, MR, and Vokes, EE. "Cisplatin, irinotecan, and bevacizumab for untreated extensive-stage small-cell lung cancer: CALGB 30306, a phase II study." J Clin Oncol 29, no. 33 (November 20, 2011): 4436-4441. Full Text Link to Item
  - Wong, NS, Fernando, NH, Bendell, JC, Morse, MA, Blobe, GC, Honeycutt, W, Pang, H, and Hurwitz, HI. "A phase II study of oxaliplatin, dose-intense capecitabine, and high-dose bevacizumab in the treatment of metastatic colorectal cancer." Clin Colorectal Cancer 10, no. 3 (September 2011): 210-216. Full Text Link to Item
  - Pang, H, Hauser, M, and Minvielle, S. "Pathway-based identification of SNPs predictive of survival." Eur J Hum Genet 19, no. 6 (June 2011): 704-709. Full Text Link to Item
  - Michiels, S, Mauguen, A, Fisher, D, Burdett, S, Paulus, R, Mandrekar, SJ, Belani, CP, Shepherd, FA, Eisen, T, Pang, H, Collette, L, Le Pechoux, C, and Pignon, J. "Evaluation of disease-free survival as surrogate endpoint for overall survival using two individual patient data meta-analyses of adjuvant chemotherapy in operable non-small cell lung cancer." Journal of Clinical Oncology 29, no. 15_suppl (May 20, 2011): 7004-7004. Full Text
  - Salama, JK, Hodgson, L, Pang, H, Green, MR, Urbanic, JJ, Blackstock, AW, Crawford, J, Bogart, J, and Vokes, EE. "Predictors of pulmonary toxicity in limited-stage (LS) small cell lung cancer (SCLC) patients treated with concurrent chemotherapy (CTX) and high-dose (70 Gy) daily radiotherapy (RT): A pooled analysis of three CALGB studies." Journal of Clinical Oncology 29, no. 15_suppl (May 20, 2011): 7078-7078. Full Text
  - Altomare, I, Bendell, JC, Bullock, KE, Uronis, HE, Morse, MA, Hsu, SD, Zafar, SY, Blobe, GC, Pang, H, Honeycutt, W, Sutton, L, and Hurwitz, HI. "A phase II trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancer." Oncologist 16, no. 8 (2011): 1131-1137. Full Text Link to Item
  - Wong, NS, Fernando, NH, Nixon, AB, Cushman, S, Aklilu, M, Bendell, JC, Morse, MA, Blobe, GC, Ashton, J, Pang, H, and Hurwitz, HI. "A phase II study of capecitabine, oxaliplatin, bevacizumab and cetuximab in the treatment of metastatic colorectal cancer." Anticancer Res 31, no. 1 (January 2011): 255-261. Link to Item
  - Dubey, S, Jänne, PA, Krug, L, Pang, H, Wang, X, Heinze, R, Watt, C, Crawford, J, Kratzke, R, Vokes, E, and Kindler, HL. "A phase II study of sorafenib in malignant mesothelioma: results of Cancer and Leukemia Group B 30307." J Thorac Oncol 5, no. 10 (October 2010): 1655-1661. Full Text Link to Item
  - Otterson, GA, Hodgson, L, Pang, H, Vokes, EE, and Cancer and Leukemia Group B, . "Phase II study of the histone deacetylase inhibitor Romidepsin in relapsed small cell lung cancer (Cancer and Leukemia Group B 30304)." J Thorac Oncol 5, no. 10 (October 2010): 1644-1648. Full Text Link to Item
  - Pang, H, Ebisu, K, Watanabe, E, Sue, LY, and Tong, T. "Analysing breast cancer microarrays from African Americans using shrinkage-based discriminant analysis." Hum Genomics 5, no. 1 (October 2010): 5-16. Link to Item
  - Dudek, A, Pang, H, Kratzke, RA, Otterson, GA, Vokes, EE, and Kindler, HL. "CALGB 30601: A phase II study of dasatinib (D) in patients (pts) with previously treated malignant mesothelioma (MM)." Journal of Clinical Oncology 28, no. 15_suppl (May 20, 2010): 7037-7037. Full Text
  - Nixon, A, Starr, M, Pang, H, Bulusu, A, Honeycutt, W, Amara, A, Bendell, JC, and Hurwitz, H. "Use of plasma angiome to predict PFS in patients with metastatic colorectal cancer (mCRC) treated with capecitabine, oxaliplatin, and bevacizumab (XELOX-A)." Journal of Clinical Oncology 28, no. 15_suppl (May 20, 2010): e21009-e21009. Full Text
  - Ready, N, Dunphy, F, Pang, H, Heinze, R, Crawford, J, and Vokes, EE. "Combination chemotherapy with sunitinib (IND 74019; NSC 736511) for untreated extensive-stage small cell lung cancer (SCLC): CALGB 30504 phase IB safety results." Journal of Clinical Oncology 28, no. 15_suppl (May 20, 2010): 7056-7056. Full Text
  - Salama, AK, Pang, H, Kratzke, RA, Richards, WG, Vokes, EE, and Salgia, R. "Interim analysis of CALGB 150607: A pilot project to study the expression of MET and P53 in resected lung adenocarcinoma specimens." Journal of Clinical Oncology 28, no. 15_suppl (May 20, 2010): 10633-10633. Full Text
  - Miller, AA, Pang, H, Hodgson, L, Ramnath, N, Otterson, GA, Kelley, MJ, Kratzke, RA, Vokes, EE, and Cancer and Leukemia Group B (CALGB), . "A phase II study of dasatinib in patients with chemosensitive relapsed small cell lung cancer (Cancer and Leukemia Group B 30602)." J Thorac Oncol 5, no. 3 (March 2010): 380-384. Full Text Link to Item
  - Pang, H, Datta, D, and Zhao, H. "Pathway analysis using random forests with bivariate node-split for survival outcomes." Bioinformatics 26, no. 2 (January 15, 2010): 250-258. Full Text Link to Item
  - Pang, H, Tong, T, and Zhao, H. "Shrinkage-based diagonal discriminant analysis and its applications in high-dimensional data." Biometrics 65, no. 4 (December 2009): 1021-1029. Full Text Link to Item
  - Miller, AA, Pang, H, Hodgson, L, Ramnath, N, Otterson, GA, and Vokes, EE. "A Phase II study of dasatinib in patients with chemo-sensitive relapsed small cell lung cancer (SCLC): CALGB 30602." JOURNAL OF THORACIC ONCOLOGY 4, no. 9 (September 2009): S816-S817. Link to Item
  - Pang, H, Datta, D, and Zhao, H. "Pathway analysis using random forests with bivariate node-split for survival outcomes." Bioinformatics 26, no. 2 (2009): 250-258. Full Text
  - Pang, H, and Zhao, H. "Building pathway clusters from Random Forests classification using class votes. (Published online)" BMC Bioinformatics 9 (February 6, 2008): 87-. Full Text Link to Item
  - Pang, H, Lin, A, Holford, M, Enerson, BE, Lu, B, Lawton, MP, Floyd, E, and Zhao, H. "Pathway analysis using random forests classification and regression." Bioinformatics 22, no. 16 (August 15, 2006): 2028-2036. Full Text Link to Item

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