Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Yale University 2008
• 

  Duke Appointment History

  • Assistant Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2008 - 2013
• Expertise
• 

  Subject Headings

  • Adenocarcinoma
  • Adult
  • Aged
  • Aged, 80 and over
  • Algorithms
  • Anesthesiology
  • Angiogenesis Inhibitors
  • Animals
  • Antibiotics, Antineoplastic
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents
  • Antineoplastic Combined Chemotherapy Protocols
  • Anxiety
  • Artificial Intelligence
  • Attitude
  • Attitude to Health
  • Benzenesulfonates
  • Bevacizumab
  • Biopsy
  • Body Mass Index
  • Breast Neoplasms
  • Camptothecin
  • Caspase 1
  • Cells, Cultured
  • Chemoradiotherapy
  • Chemotherapy
  • China
  • Cisplatin
  • Classification
  • Clinical Trials as Topic
  • Clinical Trials, Phase I as Topic
  • Cohort Studies
  • Colorectal Neoplasms
  • Computational Biology
  • Computer Simulation
  • Condoms
  • CpG Islands
  • Cranial Irradiation
  • DNA Methylation
  • DNA, Neoplasm
  • Data Interpretation, Statistical
  • Data Mining
  • Dehydration
  • Deoxycytidine
  • Depsipeptides
  • Diabetes Mellitus, Type 2
  • Diagnosis, Differential
  • Disease Progression
  • Disease-Free Survival
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Resistance, Neoplasm
  • Enzyme-Linked Immunosorbent Assay
  • Esophageal Neoplasms
  • Esophagogastric Junction
  • Extracellular Signal-Regulated MAP Kinases
  • Fatty Liver
  • Feasibility Studies
  • Female
  • Fibrosis
  • Fluorouracil
  • Gene Expression
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Genetic Predisposition to Disease
  • Genotype
  • HIV Infections
  • Hedgehog Proteins
  • Hepatic Stellate Cells
  • Histone Deacetylases
  • Homosexuality, Male
  • Human Genome Project
  • Humans
  • Hypothyroidism
  • Immunohistochemistry
  • Immunosuppressive Agents
  • Induction Chemotherapy
  • Interleukins
  • Interpersonal Relations
  • Lipase
  • Liver
  • Liver Cirrhosis
  • Lung Neoplasms
  • Lymphocyte Activation
  • Male
  • Maximum Tolerated Dose
  • Membrane Proteins
  • Mesothelioma
  • Metabolic Networks and Pathways
  • Metabolism
  • Methionine Adenosyltransferase
  • Mice
  • Microarray Analysis
  • Middle Aged
  • Models, Biological
  • Models, Statistical
  • Mutation
  • Natural Killer T-Cells
  • Neoplasm Metastasis
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Neoplasms
  • Neovascularization, Pathologic
  • Niacinamide
  • Normal Distribution
  • Oligonucleotide Array Sequence Analysis
  • Organoplatinum Compounds
  • Osteopontin
  • Oxaliplatin
  • Pancreatic Neoplasms
  • Pattern Recognition, Automated
  • Peritoneal Neoplasms
  • Phenylurea Compounds
  • Phosphatidylinositol 3-Kinases
  • Phosphorylation
  • Platelet-Derived Growth Factor
  • Pleural Neoplasms
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide
  • Prognosis
  • Protein Array Analysis
  • Proteome
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins B-raf
  • Pyridines
  • Pyrimidines
  • Questionnaires
  • Radiotherapy Dosage
  • Rats
  • Receptor, Fibroblast Growth Factor, Type 2
  • Regression Analysis
  • Research Design
  • Research Subjects
  • Retrospective Studies
  • Risk Assessment
  • Risk Reduction Behavior
  • Risk-Taking
  • Salvage Therapy
  • Severity of Illness Index
  • Sexual Behavior
  • Signal Transduction
  • Sirolimus
  • Small Cell Lung Carcinoma
  • Small cell lung cancer
  • Socioeconomic Factors
  • Software
  • Stomach Neoplasms
  • Stromal Cells
  • Survival Analysis
  • Survival Rate
  • Thyroid Hormones
  • Transcriptome
  • Treatment Outcome
  • Tumor Markers, Biological
  • Unsafe Sex
  • Urban Population
  • Validation Studies as Topic
  • Young Adult
  • ras Proteins
• Research
• 

  Selected Grants

  • Characterizing Alcohol's Effects on Repair of Liver Injury awarded by National Institutes of Health 2009 - 2012
  • Anti-VEGF in Tumors & Wounds: Efficacy vs Toxicity awarded by National Institutes of Health 2006 - 2012
• Publications & Artistic Works
• 

  Selected Publications

  • Books

    • Jung, S. H. Design and analysis of phase II cancer clinical trials, 2016. https://doi.org/10.1201/9781315371566.
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  • Academic Articles

    • Schild, Steven E., Wen Fan, Thomas E. Stinchcombe, Everett E. Vokes, Suresh S. Ramalingam, Jeffrey D. Bradley, Karen Kelly, Herbert H. Pang, and Xiaofei Wang. “Toxicity Related to Radiotherapy Dose and Targeting Strategy: A Pooled Analysis of Cooperative Group Trials of Combined Modality Therapy for Locally Advanced Non-Small Cell Lung Cancer.” J Thorac Oncol 14, no. 2 (February 2019): 298–303. https://doi.org/10.1016/j.jtho.2018.09.021.
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    • Stinchcombe, Thomas E., Wen Fan, Steven E. Schild, Everett E. Vokes, Jeff Bogart, Quynh-Thu Le, Charles R. Thomas, et al. “A pooled analysis of individual patient data from National Clinical Trials Network clinical trials of concurrent chemoradiotherapy for limited-stage small cell lung cancer in elderly patients versus younger patients.” Cancer 125, no. 3 (February 1, 2019): 382–90. https://doi.org/10.1002/cncr.31813.
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    • Schild, Steven E., Herbert H. Pang, Wen Fan, Thomas E. Stinchcombe, Everett E. Vokes, Suresh S. Ramalingam, Jeffrey D. Bradley, Karen Kelly, and Xiaofei Wang. “Exploring Radiotherapy Targeting Strategy and Dose: A Pooled Analysis of Cooperative Group Trials of Combined Modality Therapy for Stage III NSCLC.” J Thorac Oncol 13, no. 8 (August 2018): 1171–82. https://doi.org/10.1016/j.jtho.2018.04.011.
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    • Vlahovic, Gordana, Kellen L. Meadows, Ace J. Hatch, Jingquan Jia, Andrew B. Nixon, Hope E. Uronis, Michael A. Morse, et al. “A Phase I Trial of the IGF-1R Antibody Ganitumab (AMG 479) in Combination with Everolimus (RAD001) and Panitumumab in Patients with Advanced Cancer.” Oncologist 23, no. 7 (July 2018): 782–90. https://doi.org/10.1634/theoncologist.2016-0377.
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    • Chan, Sherry Kit Wa, Stephanie Wing Yan Chan, Herbert H. Pang, Kang K. Yan, Christy Lai Ming Hui, Wing Chung Chang, Edwin Ho Ming Lee, and Eric Yu Hai Chen. “Association of an Early Intervention Service for Psychosis With Suicide Rate Among Patients With First-Episode Schizophrenia-Spectrum Disorders.” Jama Psychiatry 75, no. 5 (May 1, 2018): 458–64. https://doi.org/10.1001/jamapsychiatry.2018.0185.
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    • Yan, Kang K., Hongyu Zhao, and Herbert Pang. “A comparison of graph- and kernel-based -omics data integration algorithms for classifying complex traits.” Bmc Bioinformatics 18, no. 1 (December 6, 2017): 539. https://doi.org/10.1186/s12859-017-1982-4.
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    • Han, Li, Cheuk-Kwong Lee, Herbert Pang, Hong-Tou Chan, Iek-Long Lo, Sze-Kwan Lam, Tak-Hong Cheong, and James Chung-Man Ho. “Genetic predisposition to lung adenocarcinoma among never-smoking Chinese with different epidermal growth factor receptor mutation status.” Lung Cancer 114 (December 2017): 79–89. https://doi.org/10.1016/j.lungcan.2017.10.012.
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    • Leung, Ka Chun, Carlo Mui, Wing Yan Chiu, Yuk Yiu Ng, Matthew H. Y. Chen, Pui Hung Ho, Chun Pong Kwok, et al. “Impact of patient education on influenza vaccine uptake among community-dwelling elderly: a randomized controlled trial.” Health Education Research 32, no. 5 (October 2017): 455–64. https://doi.org/10.1093/her/cyx053.
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    • Stinchcombe, Thomas E., Ying Zhang, Everett E. Vokes, Joan H. Schiller, Jeffrey D. Bradley, Karen Kelly, Walter J. Curran, et al. “Pooled Analysis of Individual Patient Data on Concurrent Chemoradiotherapy for Stage III Non-Small-Cell Lung Cancer in Elderly Patients Compared With Younger Patients Who Participated in US National Cancer Institute Cooperative Group Studies.” J Clin Oncol 35, no. 25 (September 1, 2017): 2885–92. https://doi.org/10.1200/JCO.2016.71.4758.
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    • Yao, Xiaoxin I., Xiaofei Wang, Paul J. Speicher, E Shelley Hwang, Perry Cheng, David H. Harpole, Mark F. Berry, Deborah Schrag, and Herbert H. Pang. “Reporting and Guidelines in Propensity Score Analysis: A Systematic Review of Cancer and Cancer Surgical Studies.” J Natl Cancer Inst 109, no. 8 (August 1, 2017). https://doi.org/10.1093/jnci/djw323.
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    • Quan, J., T. K. Li, H. Pang, C. H. Choi, S. C. Siu, S. Y. Tang, N. M. S. Wat, J. Woo, J. M. Johnston, and G. M. Leung. “Diabetes incidence and prevalence in Hong Kong, China during 2006-2014.” Diabet Med 34, no. 7 (July 2017): 902–8. https://doi.org/10.1111/dme.13284.
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    • Leung, Gabriel M., Michael Y. Ni, Paul Tk Wong, Paul H. Lee, Brandford Hy Chan, Sunita M. Stewart, C Mary Schooling, et al. “Cohort Profile: FAMILY Cohort.” Int J Epidemiol 46, no. 2 (April 1, 2017): e1. https://doi.org/10.1093/ije/dyu257.
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    • Ni, Michael Y., Tom K. Li, Herbert Pang, Brandford H. Y. Chan, Ichiro Kawachi, Kasisomayajula Viswanath, Catherine Mary Schooling, and Gabriel Matthew Leung. “Longitudinal Patterns and Predictors of Depression Trajectories Related to the 2014 Occupy Central/Umbrella Movement in Hong Kong.” American Journal of Public Health 107, no. 4 (April 2017): 593–600. https://doi.org/10.2105/ajph.2016.303651.
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    • Smith, E. M. L., H. Pang, C. Ye, C. Cirrincione, S. Fleishman, E. D. Paskett, T. Ahles, et al. “Predictors of duloxetine response in patients with oxaliplatin-induced painful chemotherapy-induced peripheral neuropathy (CIPN): a secondary analysis of randomised controlled trial - CALGB/alliance 170601.” European Journal of Cancer Care 26, no. 2 (March 2017). https://doi.org/10.1111/ecc.12421.
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    • Wang, Xiaofei, Xiaoyi Wang, Lydia Hodgson, Stephen L. George, Daniel J. Sargent, Nate R. Foster, Apar Kishor Ganti, et al. “Validation of Progression-Free Survival as a Surrogate Endpoint for Overall Survival in Malignant Mesothelioma: Analysis of Cancer and Leukemia Group B and North Central Cancer Treatment Group (Alliance) Trials.” Oncologist 22, no. 2 (February 2017): 189–98. https://doi.org/10.1634/theoncologist.2016-0121.
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    • Cheng, L., I. Kim, and H. Pang. “Bayesian Semiparametric Model for Pathway-Based Analysis with Zero-Inflated Clinical Outcomes.” Journal of Agricultural, Biological, and Environmental Statistics 21, no. 4 (December 1, 2016): 641–62. https://doi.org/10.1007/s13253-016-0264-3.
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    • Pang, Herbert H., Xiaofei Wang, Thomas E. Stinchcombe, Melisa L. Wong, Perry Cheng, Apar Kishor Ganti, Daniel J. Sargent, et al. “Enrollment Trends and Disparity Among Patients With Lung Cancer in National Clinical Trials, 1990 to 2012.” J Clin Oncol 34, no. 33 (November 20, 2016): 3992–99. https://doi.org/10.1200/JCO.2016.67.7088.
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    • Kuang, Ya-Shu, Sheng-Hui Li, Yong Guo, Jin-Hua Lu, Jian-Rong He, Bei-Jun Luo, Feng-Ju Jiang, et al. “Composition of gut microbiota in infants in China and global comparison.” Sci Rep 6 (November 9, 2016): 36666. https://doi.org/10.1038/srep36666.
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    • Ni, Michael Y., Tom K. Li, Herbert Pang, Brandford H. Y. Chan, Betty Y. Yuan, Ichiro Kawachi, C Mary Schooling, and Gabriel M. Leung. “Direct Participation in and Indirect Exposure to the Occupy Central Movement and Depressive Symptoms: A Longitudinal Study of Hong Kong Adults.” Am J Epidemiol 184, no. 9 (November 1, 2016): 636–43. https://doi.org/10.1093/aje/kww103.
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    • Hatch, Ace J., Alexander B. Sibley, Mark D. Starr, J Chris Brady, Chen Jiang, Jingquan Jia, Daniel L. Bowers, et al. “Blood-based markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance).” Cancer Med 5, no. 9 (September 2016): 2249–60. https://doi.org/10.1002/cam4.806.
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    • Salama, Joseph K., Lin Gu, Xiaofei Wang, Herbert H. Pang, Jeffrey A. Bogart, Jeffrey Crawford, Steven E. Schild, Everett E. Vokes, and Neal E. Ready. “Positive Interaction between Prophylactic Cranial Irradiation and Maintenance Sunitinib for Untreated Extensive-Stage Small Cell Lung Cancer Patients After Standard Chemotherapy: A Secondary Analysis of CALGB 30504 (ALLIANCE).” J Thorac Oncol 11, no. 3 (March 2016): 361–69. https://doi.org/10.1016/j.jtho.2015.11.001.
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    • Pang, Herbert, and Xiaofei Wang. “Statistical aspect of translational and correlative studies in clinical trials.” Chin Clin Oncol 5, no. 1 (February 2016): 11. https://doi.org/10.3978/j.issn.2304-3865.2014.07.04.
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    • Dong, K., H. Pang, T. Tong, and M. G. Genton. “Shrinkage-based diagonal Hotelling's tests for high-dimensional small sample size data.” Journal of Multivariate Analysis 143 (January 1, 2016): 127–42. https://doi.org/10.1016/j.jmva.2015.08.022.
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    • Ni, Michael Y., Tom K. Li, Nancy X. Yu, Herbert Pang, Brandford H. Y. Chan, Gabriel M. Leung, and Sunita M. Stewart. “Normative data and psychometric properties of the Connor-Davidson Resilience Scale (CD-RISC) and the abbreviated version (CD-RISC2) among the general population in Hong Kong.” Qual Life Res 25, no. 1 (January 2016): 111–16. https://doi.org/10.1007/s11136-015-1072-x.
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    • Yuan, Jiacheng, Herbert Pang, Tiejun Tong, Dong Xi, Wenzhao Guo, and Peter Mesenbrink. “Seamless Phase IIa/IIb and enhanced dose-finding adaptive design.” J Biopharm Stat 26, no. 5 (2016): 912–23. https://doi.org/10.1080/10543406.2015.1094807.
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    • Wang, Xiaofei, Lin Gu, Ying Zhang, Daniel J. Sargent, William Richards, Apar Kishor Ganti, Jeffery Crawford, et al. “Validation of survival prognostic models for non-small-cell lung cancer in stage- and age-specific groups.” Lung Cancer 90, no. 2 (November 2015): 281–87. https://doi.org/10.1016/j.lungcan.2015.08.007.
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    • Pang, Herbert, Inyoung Kim, and Hongyu Zhao. “Random Effects Model for Multiple Pathway Analysis with Applications to Type II Diabetes Microarray Data.” Stat Biosci 7, no. 2 (October 1, 2015): 167–86. https://doi.org/10.1007/s12561-014-9109-1.
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    • Jia, Jingquan, Andrew E. Dellinger, Eric S. Weiss, Anuradha Bulusu, Christel Rushing, Haiyan Li, Leigh A. Howard, et al. “Direct Evidence of Target Inhibition with Anti-VEGF, EGFR, and mTOR Therapies in a Clinical Model of Wound Healing.” Clin Cancer Res 21, no. 15 (August 1, 2015): 3442–52. https://doi.org/10.1158/1078-0432.CCR-14-2819.
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    • Ready, Neal E., Herbert H. Pang, Lin Gu, Gregory A. Otterson, Sachdev P. Thomas, Antonius A. Miller, Maria Baggstrom, et al. “Chemotherapy With or Without Maintenance Sunitinib for Untreated Extensive-Stage Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase II Study-CALGB 30504 (Alliance).” Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 33, no. 15 (May 2015): 1660–65. https://doi.org/10.1200/JCO.2014.57.3105.
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    • Liu, Yingmiao, Mark D. Starr, John C. Brady, Christel Rushing, Anuradha Bulusu, Herbert Pang, Wanda Honeycutt, et al. “Biomarker signatures correlate with clinical outcome in refractory metastatic colorectal cancer patients receiving bevacizumab and everolimus.” Molecular Cancer Therapeutics 14, no. 4 (April 2015): 1048–56. https://doi.org/10.1158/1535-7163.mct-14-0923-t.
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    • Nwogu, Chukwumere E., Jonathan D’Cunha, Herbert Pang, Lin Gu, Xiaofei Wang, William G. Richards, Linda J. Veit, et al. “VATS lobectomy has better perioperative outcomes than open lobectomy: CALGB 31001, an ancillary analysis of CALGB 140202 (Alliance).” The Annals of Thoracic Surgery 99, no. 2 (February 2015): 399–405. https://doi.org/10.1016/j.athoracsur.2014.09.018.
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    • Rushing, Christel, Anuradha Bulusu, Herbert I. Hurwitz, Andrew B. Nixon, and Herbert Pang. “A leave-one-out cross-validation SAS macro for the identification of markers associated with survival.” Comput Biol Med 57 (February 2015): 123–29. https://doi.org/10.1016/j.compbiomed.2014.11.015.
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    • Uronis, Hope E., Jingquan Jia, Johanna C. Bendell, Leigh Howard, Neal A. Ready, Paula H. Lee, Mark D. Starr, et al. “A Phase I/biomarker study of bevacizumab in combination with CNTO 95 in patients with advanced solid tumors.” Cancer Chemotherapy and Pharmacology 75, no. 2 (February 2015): 343–52. https://doi.org/10.1007/s00280-014-2647-x.
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    • Ni, Michael Y., Brandford H. Y. Chan, Gabriel M. Leung, Eric H. Y. Lau, and Herbert Pang. “Transmissibility of the Ice Bucket Challenge among globally influential celebrities: retrospective cohort study.” Bmj 349 (December 16, 2014): g7185. https://doi.org/10.1136/bmj.g7185.
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    • Bohinc, Brittany N., Gregory Michelotti, Guanhua Xie, Herbert Pang, Ayako Suzuki, Cynthia D. Guy, Dawn Piercy, et al. “Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism.” Endocrinology 155, no. 11 (November 2014): 4591–4601. https://doi.org/10.1210/en.2014-1302.
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    • Moylan, Cynthia A., Herbert Pang, Gregory Michelotti, and Anna Mae Diehl. “Reply: To PMID 23913408.” Hepatology (Baltimore, Md.) 60, no. 4 (October 2014): 1445–46. https://doi.org/10.1002/hep.27038.
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    • Rangwala, Fatima, Johanna C. Bendell, Mark F. Kozloff, Christy C. Arrowood, Andrew Dellinger, Jennifer Meadows, Sandra Tourt-Uhlig, et al. “Phase I study of capecitabine, oxaliplatin, bevacizumab, and everolimus in advanced solid tumors.” Invest New Drugs 32, no. 4 (August 2014): 700–709. https://doi.org/10.1007/s10637-014-0089-2.
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    • Dellinger, A. E., A. B. Nixon, and H. Pang. “Integrative pathway analysis using Graph-Based learning with applications to TCGA colon and ovarian data.” Cancer Informatics 13, no. SUPPL.4 (July 28, 2014). https://doi.org/10.4137/CIN.S13634.
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    • Liu, Yingmiao, Mark D. Starr, John C. Brady, Andrew Dellinger, Herbert Pang, Bonne Adams, Charles P. Theuer, Nam Y. Lee, Herbert I. Hurwitz, and Andrew B. Nixon. “Modulation of circulating protein biomarkers following TRC105 (anti-endoglin antibody) treatment in patients with advanced cancer.” Cancer Med 3, no. 3 (June 2014): 580–91. https://doi.org/10.1002/cam4.207.
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    • Strickler, John H., Shannon McCall, Andrew B. Nixon, John C. Brady, Herbert Pang, Christel Rushing, Allen Cohn, et al. “Phase I study of dasatinib in combination with capecitabine, oxaliplatin and bevacizumab followed by an expanded cohort in previously untreated metastatic colorectal cancer.” Invest New Drugs 32, no. 2 (April 2014): 330–39. https://doi.org/10.1007/s10637-013-0042-9.
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    • Cirrincione, Constance T., Ellen M. Lavoie Smith, and Herbert Pang. “Methodological considerations in the design and implementation of clinical trials.” Seminars in Oncology Nursing 30, no. 1 (February 2014): 74–79. https://doi.org/10.1016/j.soncn.2013.12.011.
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    • Moylan, Cynthia A., Herbert Pang, Andrew Dellinger, Ayako Suzuki, Melanie E. Garrett, Cynthia D. Guy, Susan K. Murphy, et al. “Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease.” Hepatology 59, no. 2 (February 2014): 471–82. https://doi.org/10.1002/hep.26661.
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    • Dellinger, Andrew E., Andrew B. Nixon, and Herbert Pang. “Integrative Pathway Analysis Using Graph-Based Learning with Applications to TCGA Colon and Ovarian Data.” Cancer Inform 13, no. Suppl 4 (2014): 1–9. https://doi.org/10.4137/CIN.S13634.
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    • Pang, Herbert, and Hongyu Zhao. “Stratified pathway analysis to identify gene sets associated with oral contraceptive use and breast cancer.” Cancer Informatics 13, no. Suppl 4 (January 2014): 73–78. https://doi.org/10.4137/CIN.S13973.
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    • Nixon, Andrew B., Herbert Pang, Mark D. Starr, Paula N. Friedman, Monica M. Bertagnolli, Hedy L. Kindler, Richard M. Goldberg, Alan P. Venook, Herbert I. Hurwitz, and Herbert I. Alliance for Clinical Trials In Oncology. “Prognostic and predictive blood-based biomarkers in patients with advanced pancreatic cancer: results from CALGB80303 (Alliance).” Clin Cancer Res 19, no. 24 (December 15, 2013): 6957–66. https://doi.org/10.1158/1078-0432.CCR-13-0926.
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    • Salama, Joseph K., Herbert Pang, Jeffrey A. Bogart, A William Blackstock, James J. Urbanic, Lydia Hogson, Jeffrey Crawford, and Everett E. Vokes. “Predictors of pulmonary toxicity in limited stage small cell lung cancer patients treated with induction chemotherapy followed by concurrent platinum-based chemotherapy and 70 Gy daily radiotherapy: CALGB 30904.” Lung Cancer 82, no. 3 (December 2013): 436–40. https://doi.org/10.1016/j.lungcan.2013.10.001.
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    • Murphy, Susan K., Hyuna Yang, Cynthia A. Moylan, Herbert Pang, Andrew Dellinger, Manal F. Abdelmalek, Melanie E. Garrett, et al. “Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease.” Gastroenterology 145, no. 5 (November 2013): 1076–87. https://doi.org/10.1053/j.gastro.2013.07.047.
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    • Smith, Ellen M Lavoie, and Herbert Pang. “Therapy for chemotherapy-induced peripheral neuropathy--in reply.” Jama 310, no. 5 (August 7, 2013): 538. https://doi.org/10.1001/jama.2013.7905.
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    • Salama, Joseph K., Lydia Hodgson, Herbert Pang, James J. Urbanic, A William Blackstock, Steven E. Schild, Jeffrey Crawford, Jeffrey A. Bogart, Everett E. Vokes, and Everett E. Cancer and Leukemia Group B. “A pooled analysis of limited-stage small-cell lung cancer patients treated with induction chemotherapy followed by concurrent platinum-based chemotherapy and 70 Gy daily radiotherapy: CALGB 30904.” J Thorac Oncol 8, no. 8 (August 2013): 1043–49. https://doi.org/10.1097/JTO.0b013e318293d8a4.
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    • Mauguen, Audrey, Jean-Pierre Pignon, Sarah Burdett, Caroline Domerg, David Fisher, Rebecca Paulus, Samithra J. Mandrekar, et al. “Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients' data.” Lancet Oncol 14, no. 7 (June 2013): 619–26. https://doi.org/10.1016/S1470-2045(13)70158-X.
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    • Pang, Herbert, Tiejun Tong, and Michael Ng. “Block-diagonal discriminant analysis and its bias-corrected rules.” Stat Appl Genet Mol Biol 12, no. 3 (June 2013): 347–59. https://doi.org/10.1515/sagmb-2012-0017.
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    • Uronis, Hope E., Stephanie M. Cushman, Johanna C. Bendell, Gerard C. Blobe, Michael A. Morse, Andrew B. Nixon, Andrew Dellinger, et al. “A phase I study of ABT-510 plus bevacizumab in advanced solid tumors.” Cancer Med 2, no. 3 (June 2013): 316–24. https://doi.org/10.1002/cam4.65.
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    • Smith, Ellen M Lavoie, Herbert Pang, Constance Cirrincione, Stewart Fleishman, Electra D. Paskett, Tim Ahles, Linda R. Bressler, et al. “Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial.” Jama 309, no. 13 (April 3, 2013): 1359–67. https://doi.org/10.1001/jama.2013.2813.
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    • Kim, Inyoung, Herbert Pang, and Hongyu Zhao. “Statistical properties on semiparametric regression for evaluating pathway effects.” J Stat Plan Inference 143, no. 4 (April 2013): 745–63. https://doi.org/10.1016/j.jspi.2012.09.009.
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    • Liu, Yingmiao, Mark D. Starr, Anuradha Bulusu, Herbert Pang, Nan Soon Wong, Wanda Honeycutt, Anthony Amara, Herbert I. Hurwitz, and Andrew B. Nixon. “Correlation of angiogenic biomarker signatures with clinical outcomes in metastatic colorectal cancer patients receiving capecitabine, oxaliplatin, and bevacizumab.” Cancer Med 2, no. 2 (April 2013): 234–42. https://doi.org/10.1002/cam4.71.
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    • Pang, Herbert, and Sin-Ho Jung. “Sample size considerations of prediction-validation methods in high-dimensional data for survival outcomes.” Genet Epidemiol 37, no. 3 (April 2013): 276–82. https://doi.org/10.1002/gepi.21721.
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    • Balajonda, Naraida, Tiffany L. Bisanar, Joseph P. Mathew, Herbert Pang, and Corrine I. Voils. “Determinants of a subject's decision to participate in clinical anesthesia research.” Anesth Analg 116, no. 2 (February 2013): 448–54. https://doi.org/10.1213/ANE.0b013e318277dd7d.
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    • Garrett, Melanie E., Manal F. Abdelmalek, Allison Ashley-Koch, Michael A. Hauser, Cynthia A. Moylan, Herbert Pang, Anna Mae Diehl, and Hans L. Tillmann. “IL28B rs12979860 is not associated with histologic features of NAFLD in a cohort of Caucasian North American patients.” J Hepatol 58, no. 2 (February 2013): 402–3. https://doi.org/10.1016/j.jhep.2012.09.035.
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    • Kelley, Michael J., Jeffrey A. Bogart, Lydia D. Hodgson, Rafat H. Ansari, James N. Atkins, Herbert Pang, Mark R. Green, and Everett E. Vokes. “Phase II study of induction cisplatin and irinotecan followed by concurrent carboplatin, etoposide, and thoracic radiotherapy for limited-stage small-cell lung cancer, CALGB 30206.” J Thorac Oncol 8, no. 1 (January 2013): 102–8. https://doi.org/10.1097/JTO.0b013e31827628e1.
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    • Uronis, Hope E., Johanna C. Bendell, Ivy Altomare, Gerard C. Blobe, S David Hsu, Michael A. Morse, Herbert Pang, et al. “A phase II study of capecitabine, oxaliplatin, and bevacizumab in the treatment of metastatic esophagogastric adenocarcinomas.” Oncologist 18, no. 3 (2013): 271–72. https://doi.org/10.1634/theoncologist.2012-0404.
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    • Bohinc, Brittany, Ayako Suzuki, Cynthia Guy, Herbert Pang, Dawn Piercy, Mark Feinglos, Paul Yen, Anna Mae Diehl, and Manal Abdelmalek. “The Association of Serum Thyroid Hormone Levels and Hepatic Gene Expression of Potential Regulators of Intracellular Thyroid Hormone Concentration with Severity of Nonalcoholic Fatty Liver Disease.” American Journal of Gastroenterology 107 (October 2012): S193–S193. https://doi.org/10.14309/00000434-201210001-00464.
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    • Pang, Herbert, Stephen L. George, Ken Hui, and Tiejun Tong. “Gene selection using iterative feature elimination random forests for survival outcomes.” Ieee/Acm Trans Comput Biol Bioinform 9, no. 5 (September 2012): 1422–31. https://doi.org/10.1109/TCBB.2012.63.
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    • Salgia, R., V. Nallasura, H. Pang, C. E. Rolle, W. Richards, L. Hodgson, Q. Arif, A. Husain, R. Kratzke, and E. E. Vokes. “An Interim Report Of CALGB 150607: Expression And Mutational Status Of c-MET, HGF, EGFR, KRAS, p53, c-CBL, And E-cadherin In Resected Lung Adenocarcinoma Specimens.” Journal of Thoracic Oncology 7, no. 9 (September 1, 2012): S245–46.
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    • Syn, Wing-Kin, Kolade M. Agboola, Marzena Swiderska, Gregory A. Michelotti, Evaggelia Liaskou, Herbert Pang, Guanhua Xie, et al. “NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease.” Gut 61, no. 9 (September 2012): 1323–29. https://doi.org/10.1136/gutjnl-2011-301857.
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    • Kim, Inyoung, Herbert Pang, and Hongyu Zhao. “Bayesian semiparametric regression models for evaluating pathway effects on continuous and binary clinical outcomes.” Stat Med 31, no. 15 (July 10, 2012): 1633–51. https://doi.org/10.1002/sim.4493.
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    • Dudek, Arkadiusz Z., Herbert Pang, Robert A. Kratzke, Gregory A. Otterson, Lydia Hodgson, Everett E. Vokes, Hedy L. Kindler, and Hedy L. Cancer and Leukemia Group B. “Phase II study of dasatinib in patients with previously treated malignant mesothelioma (cancer and leukemia group B 30601): a brief report.” J Thorac Oncol 7, no. 4 (April 2012): 755–59. https://doi.org/10.1097/JTO.0b013e318248242c.
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    • Kong, Travis S. K., Karen Joe Laidler, and Herbert Pang. “Relationship type, condom use and HIV/AIDS risks among men who have sex with men in six Chinese cities.” Aids Care 24, no. 4 (2012): 517–28. https://doi.org/10.1080/09540121.2011.617411.
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    • Ready, Neal E., Arkadiusz Z. Dudek, Herbert H. Pang, Lydia D. Hodgson, Stephen L. Graziano, Mark R. Green, and Everett E. Vokes. “Cisplatin, irinotecan, and bevacizumab for untreated extensive-stage small-cell lung cancer: CALGB 30306, a phase II study.” J Clin Oncol 29, no. 33 (November 20, 2011): 4436–41. https://doi.org/10.1200/JCO.2011.35.6923.
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    • Wong, Nan Soon, Nishan H. Fernando, Johanna C. Bendell, Michael A. Morse, Gerard C. Blobe, Wanda Honeycutt, Herbert Pang, and Herbert I. Hurwitz. “A phase II study of oxaliplatin, dose-intense capecitabine, and high-dose bevacizumab in the treatment of metastatic colorectal cancer.” Clin Colorectal Cancer 10, no. 3 (September 2011): 210–16. https://doi.org/10.1016/j.clcc.2011.03.018.
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    • Pang, Herbert, Michael Hauser, and Stéphane Minvielle. “Pathway-based identification of SNPs predictive of survival.” European Journal of Human Genetics : Ejhg 19, no. 6 (June 2011): 704–9. https://doi.org/10.1038/ejhg.2011.3.
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    • Michiels, S., A. Mauguen, D. Fisher, S. Burdett, R. Paulus, S. J. Mandrekar, C. P. Belani, et al. “Evaluation of disease-free survival as surrogate endpoint for overall survival using two individual patient data meta-analyses of adjuvant chemotherapy in operable non-small cell lung cancer.” Journal of Clinical Oncology 29, no. 15_suppl (May 20, 2011): 7004–7004. https://doi.org/10.1200/jco.2011.29.15_suppl.7004.
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    • Salama, J. K., L. Hodgson, H. Pang, M. R. Green, J. J. Urbanic, A. W. Blackstock, J. Crawford, J. Bogart, and E. E. Vokes. “Predictors of pulmonary toxicity in limited-stage (LS) small cell lung cancer (SCLC) patients treated with concurrent chemotherapy (CTX) and high-dose (70 Gy) daily radiotherapy (RT): A pooled analysis of three CALGB studies.” Journal of Clinical Oncology 29, no. 15_suppl (May 20, 2011): 7078–7078. https://doi.org/10.1200/jco.2011.29.15_suppl.7078.
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    • Altomare, Ivy, Johanna C. Bendell, Karen E. Bullock, Hope E. Uronis, Michael A. Morse, S David Hsu, S Yousuf Zafar, et al. “A phase II trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancer.” Oncologist 16, no. 8 (2011): 1131–37. https://doi.org/10.1634/theoncologist.2011-0078.
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    • Wong, Nan Soon, Nishan H. Fernando, Andrew B. Nixon, Stephanie Cushman, Mebea Aklilu, Johanna C. Bendell, Michael A. Morse, et al. “A phase II study of capecitabine, oxaliplatin, bevacizumab and cetuximab in the treatment of metastatic colorectal cancer.” Anticancer Res 31, no. 1 (January 2011): 255–61.
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    • Dubey, Sarita, Pasi A. Jänne, Lee Krug, Herbert Pang, Xiaofei Wang, Robin Heinze, Colleen Watt, et al. “A phase II study of sorafenib in malignant mesothelioma: results of Cancer and Leukemia Group B 30307.” J Thorac Oncol 5, no. 10 (October 2010): 1655–61. https://doi.org/10.1097/JTO.0b013e3181ec18db.
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    • Otterson, Gregory A., Lydia Hodgson, Herbert Pang, Everett E. Vokes, and Everett E. Cancer and Leukemia Group B. “Phase II study of the histone deacetylase inhibitor Romidepsin in relapsed small cell lung cancer (Cancer and Leukemia Group B 30304).” J Thorac Oncol 5, no. 10 (October 2010): 1644–48. https://doi.org/10.1097/JTO.0b013e3181ec1713.
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    • Pang, Herbert, Keita Ebisu, Emi Watanabe, Laura Y. Sue, and Tiejun Tong. “Analysing breast cancer microarrays from African Americans using shrinkage-based discriminant analysis.” Hum Genomics 5, no. 1 (October 2010): 5–16. https://doi.org/10.1186/1479-7364-5-1-5.
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    • Dudek, A., H. Pang, R. A. Kratzke, G. A. Otterson, E. E. Vokes, and H. L. Kindler. “CALGB 30601: A phase II study of dasatinib (D) in patients (pts) with previously treated malignant mesothelioma (MM).” Journal of Clinical Oncology 28, no. 15_suppl (May 20, 2010): 7037–7037. https://doi.org/10.1200/jco.2010.28.15_suppl.7037.
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    • Nixon, A., M. Starr, H. Pang, A. Bulusu, W. Honeycutt, A. Amara, J. C. Bendell, and H. Hurwitz. “Use of plasma angiome to predict PFS in patients with metastatic colorectal cancer (mCRC) treated with capecitabine, oxaliplatin, and bevacizumab (XELOX-A).” Journal of Clinical Oncology 28, no. 15_suppl (May 20, 2010): e21009–e21009. https://doi.org/10.1200/jco.2010.28.15_suppl.e21009.
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    • Ready, N., F. Dunphy, H. Pang, R. Heinze, J. Crawford, and E. E. Vokes. “Combination chemotherapy with sunitinib (IND 74019; NSC 736511) for untreated extensive-stage small cell lung cancer (SCLC): CALGB 30504 phase IB safety results.” Journal of Clinical Oncology 28, no. 15_suppl (May 20, 2010): 7056–7056. https://doi.org/10.1200/jco.2010.28.15_suppl.7056.
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    • Salama, A. K., H. Pang, R. A. Kratzke, W. G. Richards, E. E. Vokes, and R. Salgia. “Interim analysis of CALGB 150607: A pilot project to study the expression of MET and P53 in resected lung adenocarcinoma specimens.” Journal of Clinical Oncology 28, no. 15_suppl (May 20, 2010): 10633–10633. https://doi.org/10.1200/jco.2010.28.15_suppl.10633.
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    • Miller, Antonius A., Herbert Pang, Lydia Hodgson, Nithya Ramnath, Gregory A. Otterson, Michael J. Kelley, Robert A. Kratzke, Everett E. Vokes, and Everett E. Cancer and Leukemia Group B (CALGB). “A phase II study of dasatinib in patients with chemosensitive relapsed small cell lung cancer (Cancer and Leukemia Group B 30602).” J Thorac Oncol 5, no. 3 (March 2010): 380–84. https://doi.org/10.1097/JTO.0b013e3181cee36e.
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    • Pang, Herbert, Debayan Datta, and Hongyu Zhao. “Pathway analysis using random forests with bivariate node-split for survival outcomes.” Bioinformatics 26, no. 2 (January 15, 2010): 250–58. https://doi.org/10.1093/bioinformatics/btp640.
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    • Pang, Herbert, Tiejun Tong, and Hongyu Zhao. “Shrinkage-based diagonal discriminant analysis and its applications in high-dimensional data.” Biometrics 65, no. 4 (December 2009): 1021–29. https://doi.org/10.1111/j.1541-0420.2009.01200.x.
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    • Miller, Antonius A., Herbert Pang, Lydia Hodgson, Nithya Ramnath, Gregory A. Otterson, and Everett E. Vokes. “A Phase II study of dasatinib in patients with chemo-sensitive relapsed small cell lung cancer (SCLC): CALGB 30602.” Journal of Thoracic Oncology 4, no. 9 (September 1, 2009): S816–17.
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    • Pang, H., D. Datta, and H. Zhao. “Pathway analysis using random forests with bivariate node-split for survival outcomes.” Bioinformatics 26, no. 2 (2009): 250–58.
    • Pang, Herbert, and Hongyu Zhao. “Building pathway clusters from Random Forests classification using class votes.” Bmc Bioinformatics 9 (February 6, 2008): 87. https://doi.org/10.1186/1471-2105-9-87.
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    • Pang, Herbert, Aiping Lin, Matthew Holford, Bradley E. Enerson, Bin Lu, Michael P. Lawton, Eugenia Floyd, and Hongyu Zhao. “Pathway analysis using random forests classification and regression.” Bioinformatics 22, no. 16 (August 15, 2006): 2028–36. https://doi.org/10.1093/bioinformatics/btl344.
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  • Book Sections

    • George, S. L., X. Wang, and H. Pang. “Preface,” 2016. https://doi.org/10.1201/9781315371566.
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    • Pang, H., I. Kim, and H. Zhao. “Pathway-Based Methods for Analyzing Microarray Data.” In Analysis of Microarray Data: A Network-Based Approach, 355–84, 2008. https://doi.org/10.1002/9783527622818.ch13.
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  • Conference Papers

    • Pang, H., T. Stinchcombe, P. Cheng, A. W. Lee, V. H. Lee, E. E. Vokes, and X. Wang. “Comparison of chemoradiotherapy treatment strategies in stage III non-small cell lung cancer among elderly patients from multiple data sources.” In Annals of Oncology, Vol. 28. OXFORD UNIV PRESS, 2017.
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    • Wang, X., H. Lian, C. E. Nwogu, J. D’Cunha, and H. Pang. “P0124 Short-term and long-term outcomes for video-assisted thoracoscopic surgery and open lobectomy: Results from statistical analysis adjusting for treatment selection bias.” In European Journal of Cancer, 51:e26–e26. Elsevier BV, 2015. https://doi.org/10.1016/j.ejca.2015.06.077.
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    • Clarke, Jeffrey Melson, Herbert Pang, Mark D. Starr, Ace Joseph Hatch, Hedy Lee Kindler, Eileen Mary O’Reilly, Federico Innocenti, Alan P. Venook, Herbert Hurwitz, and Andrew B. Nixon. “Coagulation factors in citrated plasma predict for benefit from bevacizumab (B) in patients with advanced pancreatic cancer (APC): Results from CALGB 80303 (Alliance).” In Journal of Clinical Oncology, 33:306–306. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.3_suppl.306.
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    • Hatch, Ace Joseph, Herbert Pang, Mark D. Starr, John C. Brady, Jingquan Jia, Chen Jiang, Alexander Sibley, et al. “Prognostic and predictive blood-based biomarkers of overall survival (OS) in patients (pts) with advanced colorectal cancer (CRC) treated with cetuximab (C): Results from CALGB 80203 (Alliance).” In Journal of Clinical Oncology, 32:11022–11022. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.11022.
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    • Liu, Yingmiao, Jeffrey Melson Clarke, Mark D. Starr, John C. Brady, Herbert Pang, Christel Rushing, Delia Alvarez, et al. “Biomarker modulation in patients (pts) receiving TRC105 (T) and bevacizumab (B) in a phase Ib clinical trial.” In Journal of Clinical Oncology, 32:11020–11020. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.11020.
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    • Yang, Ju Dong, Manal F. Abdelmalek, Herbert Pang, Cynthia D. Guy, Alastair D. Smith, Anna Mae Diehl, and Ayako Suzuki. “Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis.” In Hepatology, 59:1406–14, 2014. https://doi.org/10.1002/hep.26761.
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    • Hatch, Ace J., Herbert Pang, Mark D. Starr, John C. Brady, Jingquan Jia, Donna Niedzwiecki, Alan Paul Venook, Stephanie M. Cushman, Herbert Hurwitz, and Andrew B. Nixon. “Prognostic and predictive blood-based biomarkers of overall survival (OS) in patients (pts) with advanced colorectal cancer (CRC) treated with cetuximab (C): Results from CALGB 80203 (Alliance).” In Journal of Clinical Oncology, 32:448–448. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.3_suppl.448.
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    • Bohinc, Brittany, Gregory A. Michelotti, Guanhua Xie, Herbert Pang, Ayako Suzuki, Cynthia D. Guy, Dawn L. Piercy, et al. “Repair-related Activation of Hedgehog Signaling in Stromal Cells Promotes Intrahepatic Hypothyroidism.” In Hepatology, 60:411A-412A. WILEY-BLACKWELL, 2014.
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    • Strickler, John H., Shannon McCall, Andrew B. Nixon, Herbert Pang, Christel Rushing, Christy Arrowood, Sherri Haley, Kellen Meadows, and Herbert Hurwitz. “Correlation of Src activation with response to dasatinib, capecitabine, oxaliplatin, and bevacizumab in advanced solid tumors.” In Journal of Clinical Oncology, Vol. 31. AMER SOC CLINICAL ONCOLOGY, 2013.
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    • Pang, Herbert, Lin Gu, William Richards, Jeffery Crawford, Mark Green, Everett Vokes, and Xiaofei Wang. “Abstract 4707: Validation of survival prognostic models for non-small-cell lung cancer instage- and age-specific groups.” In Clinical Research. American Association for Cancer Research, 2013. https://doi.org/10.1158/1538-7445.am2013-4707.
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    • Garrett, Melanie E., Cynthia A. Moylan, Jason Gibson, Hyuna Yang, Herbert Pang, Andrew Dellinger, Ayako Suzuki, et al. “Expression QTL analysis of a gene expression signature which predicts advanced non-alcoholic fatty liver disease.” In Hepatology, 56:267A-268A. WILEY-BLACKWELL, 2012.
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    • Suzuki, Ayako, Cynthia D. Guy, Herbert Pang, Alastair D. Smith, Anna Mae Diehl, and Manal F. Abdelmalek. “Impact of Gender and Menopause on Histologic Severity of Inflammation and Injury in patients with Nonalcoholic Fatty Liver Disease.” In Hepatology, 56:901A-901A. WILEY-BLACKWELL, 2012.
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    • Smith, Ellen M Lavoie, Herbert Pang, Constance Cirrincione, Stewart Barry Fleishman, Electra D. Paskett, Camilo E. Fadul, Chetaye Knox, Charles L. Shapiro, Paul Gilman, and Leukemia Grp B. Canc. “CALGB 170601: A phase III double blind trial of duloxetine to treat painful chemotherapy-induced peripheral neuropathy (CIPN).” In Journal of Clinical Oncology, Vol. 30, 2012.
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    • Smith, Ellen M Lavoie, Herbert Pang, Constance Cirrincione, Stewart Barry Fleishman, Electra D. Paskett, Camilo E. Fadul, Chetaye Knox, Charles L. Shapiro, and Paul Gilman. “CALGB 170601: A phase III double blind trial of duloxetine to treat painful chemotherapy-induced peripheral neuropathy (CIPN).” In Journal of Clinical Oncology, 30:CRA9013–CRA9013. American Society of Clinical Oncology (ASCO), 2012. https://doi.org/10.1200/jco.2012.30.18_suppl.cra9013.
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    • Jia, Jingquan, Haiyan Li, Andrew Dellinger, Herbert Pang, Karen Bullock Russell, Herbert Hurwitz, and Andrew B. Nixon. “Modulation of pharmacodynamic (PD) biomarkers in dermal biopsies from patients treated on a phase I study of bevacizumab (Bev) in combination with everolimus (Ev) and erlotinib (Erl) for advanced solid tumors.” In Journal of Clinical Oncology, Vol. 30. AMER SOC CLINICAL ONCOLOGY, 2012.
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    • Liu, Yingmiao, Mark Starr, John C. Brady, Herbert Pang, Andrew Dellinger, Bryan R. Leigh, Charles P. Theuer, Herbert Hurwitz, and Andrew B. Nixon. “Modulation of angiogenic biomarkers in patients receiving high-dose TRC105.” In Journal of Clinical Oncology, Vol. 30. AMER SOC CLINICAL ONCOLOGY, 2012.
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    • Tillmann, H., A. Suzuki, H. Pang, A. Dellinger, C. D. Guy, C. A. Moylan, D. Piercy, et al. “869 COFFEE CONSUMPTION INCREASES HEPATIC EXPRESSION OF CYTOCHROME P450S AND SIGNIFICANTLY REDUCES LIVER FIBROSIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE (NAFLD).” In Journal of Hepatology, 54:S346–47. Elsevier BV, 2011. https://doi.org/10.1016/s0168-8278(11)60871-4.
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