H. Frederik Nijhout
John Franklin Crowell Distinguished Professor of Biology
Fred Nijhout is broadly interested in developmental physiology and in the interactions between development and evolution. He has several lines of research ongoing in his laboratory that on the surface may look independent from one another, but all share a conceptual interest in understanding how complex traits arise through, and are affected by, the interaction of genetic and environmental factors. 1) The control of polyphenic development in insects. This work attempts to understand how the insect developmental hormones, ecdysone and juvenile hormone, act to control alternative developmental pathways within a single individual. His studies and those of his students have dealt with the control of sequential polyphenism in metamorphosis, of alternate polyphenisms in caste determination of social insects and the many seasonal forms of insects. 2) The regulation of organ and body size in insects. Ongoing research deals with the mechanism by which insects asses their body size and stop growing when they have achieved a characteristic size. Other studies deal with the control of growth and size of imaginal disks. This work is revealing that the control of body and organ size does not reside in any specific cellular or molecular mechanism but that it is a systems property in which cellular, physiological and environmental signals all contribute in inextricable ways to produce the final phenotype. 3) The development and evolution of color patterns in Lepidoptera. Ongoing research attempts to elucidate the evolution of mimicry using genetic and genomic approaches. 4) The development, genetics and evolution of complex traits. Complex traits are those whose variation is affected by many genes and environmental factors and whose inheritance does not follow Mendel’s laws. In practice this involves understanding how genetic and developmental networks operate when there is allelic variation in their genes. This work attempts to reconstruct complex traits through mathematical models of the genetic and developmental processes by which they originate, and uses these models to study the effects of mutation and selection. Currently metabolic networks are being used to develop a deeper understanding of the functional relationships between genetic variation and trait variation, and of the mechanisms by which genetic and environmental variables interact to produce phenotypes. More on web page: http://www.biology.duke.edu/nijhout/
Current Appointments & Affiliations
- John Franklin Crowell Distinguished Professor of Biology, Biology, Trinity College of Arts & Sciences 2014
- Professor of Biology, Biology, Trinity College of Arts & Sciences 2000
Contact Information
- 322 Bio Sci Bldg, Durham, NC 27708
- Duke Box 90338, Durham, NC 27708-0325
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hfn@duke.edu
(919) 684-2793
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http://www.biology.duke.edu/nijhout/
- Background
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Education, Training, & Certifications
- Ph.D., Harvard University 1974
- M.A., Harvard University 1972
- B.S., University of Notre Dame 1970
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Previous Appointments & Affiliations
- Bishop-MacDermott Family Professor of Biology in Trinity College of Arts and Sciences, Biology, Trinity College of Arts & Sciences 2002
- Professor with Tenure, Biology, Trinity College of Arts & Sciences 1987 - 2000
- Chair, Biology, Trinity College of Arts & Sciences 1991 - 1995
- Associate Professor with Tenure, Biology, Trinity College of Arts & Sciences 1981 - 1987
- Associate Professor, Biology, Trinity College of Arts & Sciences 1977 - 1981
- Recognition
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In the News
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OCT 14, 2021 Duke Research Blog -
MAR 10, 2020 -
APR 18, 2018 -
JUL 6, 2017 -
JAN 12, 2017 -
AUG 8, 2016 Duke Today -
AUG 5, 2016 -
JAN 27, 2016 New Scientist -
JAN 27, 2016 New Scientist -
JUN 22, 2015 -
JUN 22, 2015 Duke Today -
JUN 18, 2015 The Charlotte Observer -
MAR 19, 2015 Entomology Today -
MAR 19, 2015 Entomology Today -
MAR 18, 2015
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Awards & Honors
- Expertise
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Subject Headings
- Research
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External Relationships
- BIAL Biotech
- Publications & Artistic Works
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Selected Publications
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Books
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Sekimura, T., and H. F. Nijhout. Diversity and evolution of butterfly wing patterns: An integrative approach, 2017. https://doi.org/10.1007/978-981-10-4956-9.Full Text
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Nijhout, H Frederik. Insect Hormones. Princeton University Press, 1998.
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Nijhout, H Frederik. The development and evolution of butterfly wing patterns. Smithsonian Inst Pr, 1991.
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Academic Articles
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Hanna, Lisa, Tom Lamouret, Gonçalo M. Poças, Christen K. Mirth, Armin P. Moczek, Frederik H. Nijhout, and Ehab Abouheif. “Evaluating old truths: Final adult size in holometabolous insects is set by the end of larval development.” Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution, June 2022. https://doi.org/10.1002/jez.b.23165.Full Text
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Holmes, Jordan, Thorsten Lau, Rachel Saylor, Nadine Fernández-Novel, Melinda Hersey, Deanna Keen, Lena Hampel, et al. “Voltammetric Approach for Characterizing the Biophysical and Chemical Functionality of Human Induced Pluripotent Stem Cell-Derived Serotonin Neurons.” Analytical Chemistry 94, no. 25 (June 2022): 8847–56. https://doi.org/10.1021/acs.analchem.1c05082.Full Text
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Kudla, Anna M., Ximena Miranda, and H Frederik Nijhout. “The roles of growth regulation and appendage patterning genes in the morphogenesis of treehopper pronota.” Proceedings. Biological Sciences 289, no. 1976 (June 2022): 20212682. https://doi.org/10.1098/rspb.2021.2682.Full Text
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McKenna, Kenneth Z., and H Frederik Nijhout. “The development of shape. Modular control of growth in the lepidopteran forewing.” Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution 338, no. 3 (May 2022): 170–80. https://doi.org/10.1002/jez.b.23101.Full Text
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Lawley, Sean D., H Frederik Nijhout, and Michael C. Reed. “Spiracular fluttering decouples oxygen uptake and water loss: a stochastic PDE model of respiratory water loss in insects.” Journal of Mathematical Biology 84, no. 6 (April 2022): 40. https://doi.org/10.1007/s00285-022-01740-4.Full Text
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McKenna, Kenneth Z., Richard Gawne, and H Frederik Nijhout. “The genetic control paradigm in biology: What we say, and what we are entitled to mean.” Progress in Biophysics and Molecular Biology 169–170 (March 2022): 89–93. https://doi.org/10.1016/j.pbiomolbio.2022.02.003.Full Text
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Hersey, Melinda, Srimal Samaranayake, Shane N. Berger, Navid Tavakoli, Sergio Mena, H Frederik Nijhout, Michael C. Reed, et al. “Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin.” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 41, no. 30 (July 2021): 6564–77. https://doi.org/10.1523/jneurosci.2618-20.2021.Full Text Open Access Copy
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Nijhout, H Frederik, Anna Kudla, and Caleb Hazelwood. “Genetic assimilation and accommodation: Models and mechanisms.” Current Topics in Developmental Biology 141 (July 1, 2021): 337–69. https://doi.org/10.1016/bs.ctdb.2020.11.006.Full Text Link to Item
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Best, Janet, Anna Marie Buchanan, Frederik Nijhout, Parastoo Haxshemi, and Michael Reed. “Mathematical Models of Serotonin, Histamine, and Depression.” Intechopen, May 19, 2021.
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He, Lorrie L., Sara H. Shin, Zhou Wang, Isabelle Yuan, Ruthie Weschler, Allison Chiou, Takashi Koyama, H Frederik Nijhout, and Yuichiro Suzuki. “Mechanism of threshold size assessment: Metamorphosis is triggered by the TGF-beta/Activin ligand Myoglianin.” Insect Biochemistry and Molecular Biology 126 (November 2020): 103452. https://doi.org/10.1016/j.ibmb.2020.103452.Full Text
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Best, Janet, William Duncan, Farrah Sadre-Marandi, Parastoo Hashemi, H Frederik Nijhout, and Michael Reed. “Autoreceptor control of serotonin dynamics.” Bmc Neuroscience 21, no. 1 (September 2020): 40. https://doi.org/10.1186/s12868-020-00587-z.Full Text
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Gawne, R., and H. F. Nijhout. “The Arctiid Archetype: A New Lepidopteran Groundplan.” Frontiers in Ecology and Evolution 8 (June 10, 2020). https://doi.org/10.3389/fevo.2020.00175.Full Text
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McKenna, K. Z., A. M. Kudla, and H. F. Nijhout. “Anterior–Posterior Patterning in Lepidopteran Wings.” Frontiers in Ecology and Evolution 8 (June 3, 2020). https://doi.org/10.3389/fevo.2020.00146.Full Text
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He, Lorrie L., Sara Hyun Joo Shin, Zhou Wang, Isabelle Yuan, Ruthie Weschler, Allie Chiou, Takashi Koyama, H Frederik Nijhout, and Yuichiro Suzuki. “TGF-beta/Activin ligand Myoglianin couples muscle growth to the initiation of metamorphosis,” April 23, 2020. https://doi.org/10.1101/2020.04.21.053835.Full Text
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Abdalla, Aya, Alyssa West, Yunju Jin, Rachel A. Saylor, Beidi Qiang, Edsel Peña, David J. Linden, et al. “Fast serotonin voltammetry as a versatile tool for mapping dynamic tissue architecture: I. Responses at carbon fibers describe local tissue physiology.” Journal of Neurochemistry 153, no. 1 (April 2020): 33–50. https://doi.org/10.1111/jnc.14854.Full Text
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Davis, Alexander L., H Frederik Nijhout, and Sönke Johnsen. “Diverse nanostructures underlie thin ultra-black scales in butterflies.” Nature Communications 11, no. 1 (March 2020): 1294. https://doi.org/10.1038/s41467-020-15033-1.Full Text
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Bhardwaj, Shivam, Lim Si-Hui Jolander, Markus R. Wenk, Jeffrey C. Oliver, H Frederik Nijhout, and Antonia Monteiro. “Origin of the mechanism of phenotypic plasticity in satyrid butterfly eyespots.” Elife 9 (February 2020): e49544. https://doi.org/10.7554/elife.49544.Full Text
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Reed, M. C., S. Lawley, and H. F. Nijhout. “Spiracular fluttering increases oxygen uptake (Submitted),” 2020.
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Nijhout, H Frederik, and Kenneth Z. McKenna. “Allometry, Scaling, and Ontogeny of Form-An Introduction to the Symposium.” Integrative and Comparative Biology 59, no. 5 (November 2019): 1275–80. https://doi.org/10.1093/icb/icz143.Full Text
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Nijhout, H Frederik. “The multistep morphing of beetle horns.” Science (New York, N.Y.) 366, no. 6468 (November 2019): 946–47. https://doi.org/10.1126/science.aaz9010.Full Text
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Nijhout, H Frederik, Janet A. Best, and Michael C. Reed. “Systems biology of robustness and homeostatic mechanisms.” Wiley Interdisciplinary Reviews. Systems Biology and Medicine 11, no. 3 (May 2019): e1440. https://doi.org/10.1002/wsbm.1440.Full Text
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Burg, Karin R. L. van der, James J. Lewis, Arnaud Martin, H Frederik Nijhout, Charles G. Danko, and Robert D. Reed. “Contrasting Roles of Transcription Factors Spineless and EcR in the Highly Dynamic Chromatin Landscape of Butterfly Wing Metamorphosis.” Cell Reports 27, no. 4 (April 2019): 1027-1038.e3. https://doi.org/10.1016/j.celrep.2019.03.092.Full Text
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Gawne, R., and H. F. Nijhout. “Expanding the nymphalid groundplan's domain of applicability: Pattern homologies in an arctiid moth (Utetheisa ornatrix).” Biological Journal of the Linnean Society 126, no. 4 (March 27, 2019): 912–24. https://doi.org/10.1093/biolinnean/bly193.Full Text
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West, Alyssa, Janet Best, Aya Abdalla, H Frederik Nijhout, Michael Reed, and Parastoo Hashemi. “Voltammetric evidence for discrete serotonin circuits, linked to specific reuptake domains, in the mouse medial prefrontal cortex.” Neurochemistry International 123 (February 2019): 50–58. https://doi.org/10.1016/j.neuint.2018.07.004.Full Text
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Nijhout, H Frederik. “Larval Development: Making Ants into Soldiers.” Current Biology : Cb 29, no. 1 (January 2019): R32–34. https://doi.org/10.1016/j.cub.2018.11.019.Full Text
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Saylor, Rachel A., Melinda Hersey, Alyssa West, Anna Marie Buchanan, Shane N. Berger, H Frederik Nijhout, Michael C. Reed, Janet Best, and Parastoo Hashemi. “In vivo Hippocampal Serotonin Dynamics in Male and Female Mice: Determining Effects of Acute Escitalopram Using Fast Scan Cyclic Voltammetry.” Frontiers in Neuroscience 13 (January 2019): 362. https://doi.org/10.3389/fnins.2019.00362.Full Text
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Saylor, Rachel A., Melinda Hersey, Alyssa West, Anna Marie Buchanan, Shane N. Berger, H Frederik Nijhout, Michael C. Reed, Janet Best, and Parastoo Hashemi. “Corrigendum: In vivo Hippocampal Serotonin Dynamics in Male and Female Mice: Determining Effects of Acute Escitalopram Using Fast Scan Cyclic Voltammetry.” Frontiers in Neuroscience 13 (January 2019): 726. https://doi.org/10.3389/fnins.2019.00726.Full Text
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Sadre-Marandi, Farrah, Thabat Dahdoul, Michael C. Reed, and H Frederik Nijhout. “Sex differences in hepatic one-carbon metabolism.” Bmc Systems Biology 12, no. 1 (October 2018): 89. https://doi.org/10.1186/s12918-018-0621-7.Full Text
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Nijhout, H Frederik, and Kenneth Z. McKenna. “Wing morphogenesis in Lepidoptera.” Progress in Biophysics and Molecular Biology 137 (September 2018): 88–94. https://doi.org/10.1016/j.pbiomolbio.2018.04.008.Full Text
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Nijhout, H Frederik, Emily Laub, and Laura W. Grunert. “Hormonal control of growth in the wing imaginal disks of Junonia coenia: the relative contributions of insulin and ecdysone.” Development (Cambridge, England) 145, no. 6 (March 2018): dev160101. https://doi.org/10.1242/dev.160101.Full Text
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Nijhout, H Frederik, and Kenneth Z. McKenna. “The distinct roles of insulin signaling in polyphenic development.” Current Opinion in Insect Science 25 (February 2018): 58–64. https://doi.org/10.1016/j.cois.2017.11.011.Full Text
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Gawne, Richard, Kenneth Z. McKenna, and H Frederik Nijhout. “Unmodern Synthesis: Developmental Hierarchies and the Origin of Phenotypes.” Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology 40, no. 1 (January 2018). https://doi.org/10.1002/bies.201600265.Full Text
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Parens, Raphael, H Frederik Nijhout, Alfredo Morales, Felipe Xavier Costa, and Yaneer Bar-Yam. “A Possible Link Between Pyriproxyfen and Microcephaly.” Plos Currents 9 (November 2017): ecurrents.outbreaks.5afb0bfb8cf31d9a4baba7b19b4edb. https://doi.org/10.1371/currents.outbreaks.5afb0bfb8cf31d9a4baba7b19b4edbac.Full Text
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Reed, Michael, Janet Best, Martin Golubitsky, Ian Stewart, and H Frederik Nijhout. “Analysis of Homeostatic Mechanisms in Biochemical Networks.” Bulletin of Mathematical Biology 79, no. 11 (November 2017): 2534–57. https://doi.org/10.1007/s11538-017-0340-z.Full Text
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Nijhout, H Frederik, Farrah Sadre-Marandi, Janet Best, and Michael C. Reed. “Systems Biology of Phenotypic Robustness and Plasticity.” Integrative and Comparative Biology 57, no. 2 (August 2017): 171–84. https://doi.org/10.1093/icb/icx076.Full Text Open Access Copy
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Reed, M. C., H. F. Nijhout, Janet Best, S. Samaranayake, and P. Hashemi. “A mathematical model for histamine synthesis, release, and control in varicosities.” Theoretical Biology and Medical Modelling 14 (2017): 12–12. https://doi.org/10.1186/s12976-017-0070-9.Full Text Open Access Copy
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Reed, M. C., J. Best, and H. F. Nijhout. “Mathematical models of neuromodulation and implications for neurology and psychiatry (Accepted).” Edited by P. Erdi, B. Battacharya, and A. Cochran, 2017.
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Davidowitz, Goggy, Derek Roff, and H Frederik Nijhout. “Synergism and Antagonism of Proximate Mechanisms Enable and Constrain the Response to Simultaneous Selection on Body Size and Development Time: An Empirical Test Using Experimental Evolution.” The American Naturalist 188, no. 5 (November 2016): 499–520. https://doi.org/10.1086/688653.Full Text
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Samaranayake, Srimal, Aya Abdalla, Rhiannon Robke, H Frederik Nijhout, Michael C. Reed, Janet Best, and Parastoo Hashemi. “A voltammetric and mathematical analysis of histaminergic modulation of serotonin in the mouse hypothalamus.” Journal of Neurochemistry 138, no. 3 (August 2016): 374–83. https://doi.org/10.1111/jnc.13659.Full Text
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Temamogullari, N Ezgi, H Frederik Nijhout, and Michael C Reed. “Mathematical modeling of perifusion cell culture experiments on GnRH signaling.” Mathematical Biosciences 276 (June 2016): 121–32. https://doi.org/10.1016/j.mbs.2016.03.016.Full Text
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Reed, M. C., S. Lawley, and H. F. Nijhout. “Spiracular fluttering increases oxygen uptake (Submitted),” 2016.
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Reed, Michael C., Mary V. Gamble, Megan N. Hall, and H Frederik Nijhout. “Mathematical analysis of the regulation of competing methyltransferases.” Bmc Systems Biology 9 (October 2015): 69. https://doi.org/10.1186/s12918-015-0215-6.Full Text
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Nijhout, H Frederik, Janet A. Best, and Michael C. Reed. “Using mathematical models to understand metabolism, genes, and disease.” Bmc Biology 13 (September 2015): 79. https://doi.org/10.1186/s12915-015-0189-2.Full Text
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Nijhout, H Frederik. “Big or fast: two strategies in the developmental control of body size.” Bmc Biology 13 (August 2015): 57. https://doi.org/10.1186/s12915-015-0173-x.Full Text Open Access Copy
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Bilinsky, L. M., M. C. Reed, and H. F. Nijhout. “The role of skeletal muscle in liver glutathione metabolism during acetaminophen overdose.” Journal of Theoretical Biology 376 (July 2015): 118–33. https://doi.org/10.1016/j.jtbi.2015.04.006.Full Text
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Nijhout, H Frederik. “To plasticity and back again.” Elife 4 (March 2015). https://doi.org/10.7554/elife.06995.Full Text Open Access Copy
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Xu, Hai-Jun, Jian Xue, Bo Lu, Xue-Chao Zhang, Ji-Chong Zhuo, Shu-Fang He, Xiao-Fang Ma, et al. “Two insulin receptors determine alternative wing morphs in planthoppers.” Nature 519, no. 7544 (March 2015): 464–67. https://doi.org/10.1038/nature14286.Full Text
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Grunert, Laura W., Jameson W. Clarke, Chaarushi Ahuja, Harish Eswaran, and H Frederik Nijhout. “A Quantitative Analysis of Growth and Size Regulation in Manduca sexta: The Physiological Basis of Variation in Size and Age at Metamorphosis.” Plos One 10, no. 5 (January 2015): e0127988. https://doi.org/10.1371/journal.pone.0127988.Full Text Open Access Copy
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Nijhout, H Frederik, and Viviane Callier. “Developmental mechanisms of body size and wing-body scaling in insects.” Annual Review of Entomology 60 (January 2015): 141–56. https://doi.org/10.1146/annurev-ento-010814-020841.Full Text
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Nijhout, H Frederik, Janet Best, and Michael C. Reed. “Escape from homeostasis.” Mathematical Biosciences 257 (November 2014): 104–10. https://doi.org/10.1016/j.mbs.2014.08.015.Full Text
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Wood, Kevin M., Anisa Zeqja, H Frederik Nijhout, Michael C. Reed, Janet Best, and Parastoo Hashemi. “Voltammetric and mathematical evidence for dual transport mediation of serotonin clearance in vivo.” Journal of Neurochemistry 130, no. 3 (August 2014): 351–59. https://doi.org/10.1111/jnc.12733.Full Text
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Callier, Viviane, and H Frederik Nijhout. “Plasticity of insect body size in response to oxygen: integrating molecular and physiological mechanisms.” Current Opinion in Insect Science 1 (July 2014): 59–65. https://doi.org/10.1016/j.cois.2014.05.007.Full Text
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Nijhout, H Frederik, and Michael C. Reed. “Homeostasis and dynamic stability of the phenotype link robustness and plasticity.” Integrative and Comparative Biology 54, no. 2 (July 2014): 264–75. https://doi.org/10.1093/icb/icu010.Full Text
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Silva, Vanessa R. da, Maria A. Ralat, Eoin P. Quinlivan, Barbara N. DeRatt, Timothy J. Garrett, Yueh-Yun Chi, H. Frederik Nijhout, Michael C. Reed, and Jesse F. Gregory. “Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells.” American Journal of Physiology. Endocrinology and Metabolism 307, no. 1 (July 2014): E93-101. https://doi.org/10.1152/ajpendo.00697.2013.Full Text
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Lawley, Sean D., Jina Yun, Mary V. Gamble, Megan N. Hall, Michael C. Reed, and H Frederik Nijhout. “Mathematical modeling of the effects of glutathione on arsenic methylation.” Theoretical Biology & Medical Modelling 11 (May 2014): 20. https://doi.org/10.1186/1742-4682-11-20.Full Text
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Nijhout, H Frederik, Margaret Cinderella, and Laura W. Grunert. “The development of wing shape in Lepidoptera: mitotic density, not orientation, is the primary determinant of shape.” Evolution & Development 16, no. 2 (March 2014): 68–77. https://doi.org/10.1111/ede.12065.Full Text
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Pujo-Menjouet, L., M. Reed, H. F. Nijhout, and J. Best. “Projecting biochemistry over long distances.” Mathematical Modelling of Natural Phenomena 9, no. 1 (February 20, 2014): 133–38. https://doi.org/10.1051/mmnp/20149109.Full Text
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Nijhout, H Frederik, Lynn M. Riddiford, Christen Mirth, Alexander W. Shingleton, Yuichiro Suzuki, and Viviane Callier. “The developmental control of size in insects.” Wiley Interdisciplinary Reviews. Developmental Biology 3, no. 1 (January 2014): 113–34. https://doi.org/10.1002/wdev.124.Full Text
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Callier, Viviane, and H Frederik Nijhout. “Body size determination in insects: a review and synthesis of size- and brain-dependent and independent mechanisms.” Biological Reviews of the Cambridge Philosophical Society 88, no. 4 (November 2013): 944–54. https://doi.org/10.1111/brv.12033.Full Text
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Frederik Nijhout, H. “Arthropod developmental endocrinology,” October 1, 2013, 123–48. https://doi.org/10.1007/978-3-642-36160-9_6.Full Text
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Rios-Avila, Luisa, H Frederik Nijhout, Michael C. Reed, Harry S. Sitren, and Jesse F. Gregory. “A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites.” The Journal of Nutrition 143, no. 9 (September 2013): 1509–19. https://doi.org/10.3945/jn.113.174599.Full Text
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Duncan, Tanya M., Michael C. Reed, and H Frederik Nijhout. “A population model of folate-mediated one-carbon metabolism.” Nutrients 5, no. 7 (July 2013): 2457–74. https://doi.org/10.3390/nu5072457.Full Text Open Access Copy
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Duncan, Tanya M., Michael C. Reed, and H Frederik Nijhout. “The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model.” Molecular Nutrition & Food Research 57, no. 4 (April 2013): 628–36. https://doi.org/10.1002/mnfr.201200125.Full Text
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Cho, Eugenia H., and H Frederik Nijhout. “Development of polyploidy of scale-building cells in the wings of Manduca sexta.” Arthropod Structure & Development 42, no. 1 (January 2013): 37–46. https://doi.org/10.1016/j.asd.2012.09.003.Full Text
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Nijhout, H Frederik, and Viviane Callier. “A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network.” Frontiers in Physiology 4 (January 2013): 245. https://doi.org/10.3389/fphys.2013.00245.Full Text
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Papa, Riccardo, Durrell D. Kapan, Brian A. Counterman, Karla Maldonado, Daniel P. Lindstrom, Robert D. Reed, H Frederik Nijhout, Tomas Hrbek, and W Owen McMillan. “Multi-allelic major effect genes interact with minor effect QTLs to control adaptive color pattern variation in Heliconius erato.” Plos One 8, no. 3 (January 2013): e57033. https://doi.org/10.1371/journal.pone.0057033.Full Text
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Reed, Michael C., H Frederik Nijhout, and Janet Best. “Computational studies of the role of serotonin in the basal ganglia.” Frontiers in Integrative Neuroscience 7 (January 2013): 41. https://doi.org/10.3389/fnint.2013.00041.Full Text
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Padmanabha, Harish, Fabio Correa, Mathieu Legros, H Fredrick Nijhout, Cynthia Lord, and L Philip Lounibos. “An eco-physiological model of the impact of temperature on Aedes aegypti life history traits.” Journal of Insect Physiology 58, no. 12 (December 2012): 1597–1608. https://doi.org/10.1016/j.jinsphys.2012.09.015.Full Text
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Obeid, Rima, Kathrin Hartmuth, Wolfgang Herrmann, Ludwig Gortner, Tilman R. Rohrer, Jürgen Geisel, Michael C. Reed, and H Frederik Nijhout. “Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model.” Molecular Nutrition & Food Research 56, no. 10 (October 2012): 1582–89. https://doi.org/10.1002/mnfr.201200162.Full Text
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Davidowitz, Goggy, H Frederik Nijhout, and Derek A. Roff. “Predicting the response to simultaneous selection: genetic architecture and physiological constraints.” Evolution; International Journal of Organic Evolution 66, no. 9 (September 2012): 2916–28. https://doi.org/10.1111/j.1558-5646.2012.01644.x.Full Text
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Geenen, Suzanne, Franco B. du Preez, Michael Reed, H Frederik Nijhout, J Gerry Kenna, Ian D. Wilson, Hans V. Westerhoff, and Jacky L. Snoep. “A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism.” European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences 46, no. 4 (July 2012): 233–43. https://doi.org/10.1016/j.ejps.2011.08.017.Full Text
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Nijhout, H Frederik, and Rebecca Z. German. “Developmental causes of allometry: new models and implications for phenotypic plasticity and evolution.” Integrative and Comparative Biology 52, no. 1 (July 2012): 43–52. https://doi.org/10.1093/icb/ics068.Full Text
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Hines, H. M., R. Papa, M. Ruiz, A. Papanicolaou, C. Wang, H. F. Nijhout, W. O. McMillan, and R. D. Reed. “Transcriptome analysis reveals novel patterning and pigmentation genes underlying Heliconius butterfly wing pattern variation.” Bmc Genomics. 13:288 (June 2012). https://doi.org/10.1186/1471-2164-13-288.Full Text
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Ben Shachar, R., Y. Chen, S. Luo, C. Hartman, M. Reed, and H. F. Nijhout. “The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model (Accepted).” Theoretical Biology and Medical Modeling, 2012.
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Callier, Viviane, and H Frederik Nijhout. “Supply-side constraints are insufficient to explain the ontogenetic scaling of metabolic rate in the tobacco Hornworm, Manduca sexta.” Plos One 7, no. 9 (January 2012): e45455. https://doi.org/10.1371/journal.pone.0045455.Full Text
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Reed, M., H. F. Nijhout, and J. Best. “Mathematical insights into the effects of levodopa.” Frontiers in Integrative Neuroscience 6 (2012): 1–24.
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Nijhout, H Frederik. “Dependence of morphometric allometries on the growth kinetics of body parts.” Journal of Theoretical Biology 288 (November 2011): 35–43. https://doi.org/10.1016/j.jtbi.2011.08.008.Full Text
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Moczek, Armin P., Sonia Sultan, Susan Foster, Cris Ledón-Rettig, Ian Dworkin, H Fred Nijhout, Ehab Abouheif, and David W. Pfennig. “The role of developmental plasticity in evolutionary innovation.” Proceedings. Biological Sciences 278, no. 1719 (September 2011): 2705–13. https://doi.org/10.1098/rspb.2011.0971.Full Text
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Neuhouser, Marian L., H Frederik Nijhout, Jesse F. Gregory, Michael C. Reed, S Jill James, Amy Liu, Barry Shane, and Cornelia M. Ulrich. “Mathematical modeling predicts the effect of folate deficiency and excess on cancer-related biomarkers.” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 20, no. 9 (September 2011): 1912–17. https://doi.org/10.1158/1055-9965.epi-10-1352.Full Text
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Lawley, S. D., M. Cinderella, M. N. Hall, M. V. Gamble, H. F. Nijhout, and M. C. Reed. “Mathematical model insights into arsenic detoxification.” Theoretical Biology and Medical Modelling 8, no. 1 (August 30, 2011). https://doi.org/10.1186/1742-4682-8-31.Full Text
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Callier, Viviane, and H Frederik Nijhout. “Control of body size by oxygen supply reveals size-dependent and size-independent mechanisms of molting and metamorphosis.” Proceedings of the National Academy of Sciences of the United States of America 108, no. 35 (August 2011): 14664–69. https://doi.org/10.1073/pnas.1106556108.Full Text
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Lawley, Sean D., Molly Cinderella, Megan N. Hall, Mary V. Gamble, H Frederik Nijhout, and Michael C. Reed. “Mathematical model insights into arsenic detoxification.” Theoretical Biology & Medical Modelling 8 (August 2011): 31. https://doi.org/10.1186/1742-4682-8-31.Full Text
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Reed, R. D., R. Papa, A. Martin, H. M. Hines, B. A. Counterman, C. Pardo Diaz, C. D. Jiggins, et al. “optix Drives the Repeated Convergent Evolution of Butterfly Wing Pattern Mimicry.” Science 333 (August 2011): 1137–41.
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Best, J., H. F. Nijhout, and M. Reed. “Bursts and the efficacy of selective serotonin reuptake inhibitors.” Pharmacopsychiatry 44 Suppl 1 (May 2011): S76–83. https://doi.org/10.1055/s-0031-1273697.Full Text
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Nijhout, H Frederik, and Laura W. Grunert. “The cellular and physiological mechanism of wing-body scaling in Manduca sexta.” Science (New York, N.Y.) 330, no. 6011 (December 2010): 1693–95. https://doi.org/10.1126/science.1197292.Full Text
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Tobler, A., and H. F. Nijhout. “Developmental constraints on the evolution of wing-body allometry in Manduca sexta.” Evolution & Development 12 (November 2010): 57–66.
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Tobler, Alexandra, and H Frederik Nijhout. “Developmental constraints on the evolution of wing-body allometry in Manduca sexta.” Evolution & Development 12, no. 6 (November 2010): 592–600. https://doi.org/10.1111/j.1525-142x.2010.00444.x.Full Text
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Best, Janet, H Frederik Nijhout, and Michael Reed. “Serotonin synthesis, release and reuptake in terminals: a mathematical model.” Theoretical Biology & Medical Modelling 7 (August 2010): 34. https://doi.org/10.1186/1742-4682-7-34.Full Text Open Access Copy
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Best, J., M. Reed, and H. F. Nijhout. “Models of dopaminergic and serotonergic signaling.” Pharmacopsychiatry 43 Suppl 1 (May 2010): S61–66. https://doi.org/10.1055/s-0030-1252024.Full Text
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Frederik Nijhout, H. “Photoperiodism in Insects: Effects on Morphology,” May 1, 2010. https://doi.org/10.1093/acprof:oso/9780195335903.003.0013.Full Text
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Reed, Michael C., Anna Lieb, and H Frederik Nijhout. “The biological significance of substrate inhibition: a mechanism with diverse functions.” Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology 32, no. 5 (May 2010): 422–29. https://doi.org/10.1002/bies.200900167.Full Text
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Tobler, Alexandra, and H Frederik Nijhout. “A switch in the control of growth of the wing imaginal disks of Manduca sexta.” Plos One 5, no. 5 (May 2010): e10723. https://doi.org/10.1371/journal.pone.0010723.Full Text Open Access Copy
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Diamond, S. E., S. D. Hawkins, H. F. Nijhout, and J. G. Kingsolver. “Evolutionary divergence of field and laboratory populations of Manduca sexta in response to host-plant quality.” Ecological Entomology 35, no. 2 (April 1, 2010): 166–74. https://doi.org/10.1111/j.1365-2311.2009.01166.x.Full Text
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Rios-Avila, Luisa, H Frederik Nijhout, Michael C. Reed, Harry S. Sitren, and Jesse F. Gregory. “Mathematical model gives insights into vitamin B6 and kynurenine metabolism.” Faseb Journal 24 (April 2010).Link to Item
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Nijhout, H Frederik, Derek A. Roff, and Goggy Davidowitz. “Conflicting processes in the evolution of body size and development time.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 365, no. 1540 (February 2010): 567–75. https://doi.org/10.1098/rstb.2009.0249.Full Text
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Nijhout, H. F. “Molecular and Physiological Basis of Colour Pattern Formation” 38, no. C (January 1, 2010): 219–65. https://doi.org/10.1016/S0065-2806(10)38002-7.Full Text
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Tobler, A., and H. F. Nijhout. “A switch in the control of growth of the wing imaginal disks of Manduca sexta.” Plos One 5, no. 5 (2010). https://doi.org/10.1371/journal.pone.0010723.Full Text
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Bowsher, Julia H., and H Frederik Nijhout. “Partial co-option of the appendage patterning pathway in the development of abdominal appendages in the sepsid fly Themira biloba.” Development Genes and Evolution 219, no. 11–12 (December 2009): 577–87. https://doi.org/10.1007/s00427-010-0319-3.Full Text
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Howell, Audrey S., Natasha S. Savage, Sam A. Johnson, Indrani Bose, Allison W. Wagner, Trevin R. Zyla, H Frederik Nijhout, Michael C. Reed, Andrew B. Goryachev, and Daniel J. Lew. “Singularity in polarization: rewiring yeast cells to make two buds.” Cell 139, no. 4 (November 13, 2009): 731–43. https://doi.org/10.1016/j.cell.2009.10.024.Full Text Link to Item
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Thomas, D. C., D. V. Conti, J. Baurley, F. Nijhout, M. Reed, and C. M. Ulrich. “Use of pathway information in molecular epidemiology (Accepted).” Human Genomics, October 1, 2009. https://doi.org/10.1186/1479-7364-4-1-21.Full Text
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Thomas, Duncan C., David V. Conti, James Baurley, Frederik Nijhout, Michael Reed, and Cornelia M. Ulrich. “Use of pathway information in molecular epidemiology.” Human Genomics 4, no. 1 (October 2009): 21–42. https://doi.org/10.1186/1479-7364-4-1-21.Full Text
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Reed, M. C., J. Best, and H. F. Nijhout. “Passive and active stabilization of dopamine in the striatum.” Bioscience Hypotheses 2, no. 4 (June 3, 2009): 240–44. https://doi.org/10.1016/j.bihy.2009.03.008.Full Text
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Nijhout, H Frederik, Jesse F. Gregory, Courtney Fitzpatrick, Eugenia Cho, K Yvonne Lamers, Cornelia M. Ulrich, and Michael C. Reed. “A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism.” The Journal of Nutrition 139, no. 4 (April 2009): 784–91. https://doi.org/10.3945/jn.109.104265.Full Text
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Preuss, K. M., and H. F. Nijhout. “The importance of threshold size for the initiation of metamorphosis in the insect Tribolium castaneum.” Integrative and Comparative Biology 49 (February 1, 2009): E291–E291.Link to Item
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Best, J., H. F. Nijhout, and M. Reed. “Homeostatic mechanisms in dopamine synthesis and release: a mathematical model.” Theoretical Biology and Medical Modeling 6 (2009): 21.
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Nijhout, H. F., and Y. Suzuki. “Environment and genetic accommodation.” Biological Theory 3, no. 1–9 (2009).
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Suzuki, Yuichiro, and H Frederik Nijhout. “Constraint and developmental dissociation of phenotypic integration in a genetically accommodated trait.” Evolution & Development 10, no. 6 (November 2008): 690–99. https://doi.org/10.1111/j.1525-142x.2008.00282.x.Full Text
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Nijhout, H Frederik. “Size matters (but so does time), and it's OK to be different.” Developmental Cell 15, no. 4 (October 2008): 491–92. https://doi.org/10.1016/j.devcel.2008.09.014.Full Text
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Nijhout, H. F., M. Reed, and C. Ulrich. “Mathematical models of one-carbon metabolism.” Vitamins and Hormones 79 (September 2008): 45–82.
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Nijhout, H. F., and Y. Suzuki. “Environment and Genetic Accommodation.” Biological Theory 3, no. 3 (September 1, 2008): 204–12. https://doi.org/10.1162/biot.2008.3.3.204.Full Text
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Ulrich, Cornelia M., Michael C. Reed, and H Frederik Nijhout. “Modeling folate, one-carbon metabolism, and DNA methylation.” Nutrition Reviews 66 Suppl 1 (August 2008): S27–30. https://doi.org/10.1111/j.1753-4887.2008.00062.x.Full Text
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Ulrich, Cornelia M., Marian Neuhouser, Amy Y. Liu, Alanna Boynton, Jesse F. Gregory, Barry Shane, S Jill James, Michael C. Reed, and H Frederik Nijhout. “Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis.” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 17, no. 7 (July 2008): 1822–31. https://doi.org/10.1158/1055-9965.epi-07-2937.Full Text
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Nijhout, H. F. “Developmental phenotypic landscapes.” Evolutionary Biology 35, no. 2 (June 1, 2008): 100–103. https://doi.org/10.1007/s11692-008-9024-9.Full Text
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Reed, Michael C., Rachel L. Thomas, Jovana Pavisic, S Jill James, Cornelia M. Ulrich, and H Frederik Nijhout. “A mathematical model of glutathione metabolism.” Theoretical Biology & Medical Modelling 5 (April 2008): 8. https://doi.org/10.1186/1742-4682-5-8.Full Text
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Nijhout, H Frederik, and Michael C. Reed. “A mathematical model for the regulation of juvenile hormone titers.” Journal of Insect Physiology 54, no. 1 (January 2008): 255–64. https://doi.org/10.1016/j.jinsphys.2007.09.008.Full Text
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Nijhout, H. F., M. C. Reed, and C. M. Ulrich. “Mathematical models of folate-mediated one-carbon metabolism.” Vitamins and Hormones 79 (January 2008): 45–82. https://doi.org/10.1016/s0083-6729(08)00402-0.Full Text
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Suzuki, Y., and H. F. Nijhout. “Genetic basis of adaptive evolution of a polyphenism by genetic accommodation.” Journal of Evolutionary Biology 21, no. 1 (January 2008): 57–66. https://doi.org/10.1111/j.1420-9101.2007.01464.x.Full Text
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Leduc, Damien, Frédéric Escartin, H Frederik Nijhout, Michael C. Reed, Ursula Liebl, Stéphane Skouloubris, and Hannu Myllykallio. “Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria.” Journal of Bacteriology 189, no. 23 (December 2007): 8537–45. https://doi.org/10.1128/jb.01380-07.Full Text
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Anderson, David F., Jonathan C. Mattingly, H Frederik Nijhout, and Michael C. Reed. “Propagation of fluctuations in biochemical systems, I: linear SSC networks.” Bulletin of Mathematical Biology 69, no. 6 (August 2007): 1791–1813. https://doi.org/10.1007/s11538-007-9192-2.Full Text Open Access Copy
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Bowsher, Julia H., and H Frederik Nijhout. “Evolution of novel abdominal appendages in a sepsid fly from histoblasts, not imaginal discs.” Evolution & Development 9, no. 4 (July 2007): 347–54. https://doi.org/10.1111/j.1525-142x.2007.00171.x.Full Text
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Shingleton, Alexander W., W Anthony Frankino, Thomas Flatt, H Frederik Nijhout, and Douglas J. Emlen. “Size and shape: the developmental regulation of static allometry in insects.” Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology 29, no. 6 (June 2007): 536–48. https://doi.org/10.1002/bies.20584.Full Text
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Nijhout, H Frederik, Wendy A. Smith, Ira Schachar, Srikanth Subramanian, Alexandra Tobler, and Laura W. Grunert. “The control of growth and differentiation of the wing imaginal disks of Manduca sexta.” Developmental Biology 302, no. 2 (February 2007): 569–76. https://doi.org/10.1016/j.ydbio.2006.10.023.Full Text
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Nijhout, H. F., M. C. Reed, and C. M. Ulrich. “A day in the life of cell metabolism.” Biological Theory (In Press), 2007.
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Reed, R. D., P. H. Chen, and H. F. Nijhout. “Cryptic variation in butterfly eyespot development: the importance of sample size in gene expression studies.” Evolution & Development 9 (2007): 2–9.
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Nijhout, H Frederik, Michael C. Reed, Shi-Ling Lam, Barry Shane, Jesse F. Gregory, and Cornelia M. Ulrich. “In silico experimentation with a model of hepatic mitochondrial folate metabolism.” Theoretical Biology & Medical Modelling 3 (December 2006): 40. https://doi.org/10.1186/1742-4682-3-40.Full Text
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Boyles, Abee L., Ashley V. Billups, Kristen L. Deak, Deborah G. Siegel, Lorraine Mehltretter, Susan H. Slifer, Alexander G. Bassuk, et al. “Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions.” Environ Health Perspect 114, no. 10 (October 2006): 1547–52. https://doi.org/10.1289/ehp.9166.Full Text Link to Item
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Reed, Michael C., H Frederik Nijhout, Marian L. Neuhouser, Jesse F. Gregory, Barry Shane, S Jill James, Alanna Boynton, and Cornelia M. Ulrich. “A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism.” The Journal of Nutrition 136, no. 10 (October 2006): 2653–61. https://doi.org/10.1093/jn/136.10.2653.Full Text
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Brandon, R. N., and H. F. Nijhout. “The empirical nonequivalence of genie and genotypic models of selection: A (Decisive) refutation of genie selectionism and pluralistic genie selectionism.” Philosophy of Science 73, no. 3 (July 1, 2006): 277–97. https://doi.org/10.1086/515416.Full Text
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Ulrich, Cornelia M., H Frederik Nijhout, and Michael C. Reed. “Mathematical modeling: epidemiology meets systems biology.” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 15, no. 5 (May 2006): 827–29. https://doi.org/10.1158/1055-9965.epi-06-0252.Full Text
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Veitia, Reiner A., and H Frederik Nijhout. “The robustness of the transcriptional response to alterations in morphogenetic gradients.” Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology 28, no. 3 (March 2006): 282–89. https://doi.org/10.1002/bies.20377.Full Text
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Suzuki, Yuichiro, and H Frederik Nijhout. “Evolution of a polyphenism by genetic accommodation.” Science (New York, N.Y.) 311, no. 5761 (February 2006): 650–52. https://doi.org/10.1126/science.1118888.Full Text
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Nijhout, H Frederik, Michael C. Reed, David F. Anderson, Jonathan C. Mattingly, S Jill James, and Cornelia M. Ulrich. “Long-Range Allosteric Interactions between the Folate and Methionine Cycles Stabilize DNA Methylation Reaction Rate.” Epigenetics 1 (2006): 115–115.
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Nijhout, H. F., G. Davidowitz, and D. A. Roff. “A quantitative analysis of the mechanism that controls body size in Manduca sexta.” Journal of Biology 5, no. 5 (January 2006): 16. https://doi.org/10.1186/jbiol43.Full Text
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Davidowitz, Goggy, Derek A. Roff, and H Frederik Nijhout. “A physiological perspective on the response of body size and development time to simultaneous directional selection.” Integrative and Comparative Biology 45, no. 3 (June 2005): 525–31. https://doi.org/10.1093/icb/45.3.525.Full Text
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Davidowitz, Goggy, and H Frederik Nijhout. “The physiological basis of reaction norms: the interaction among growth rate, the duration of growth and body size.” Integrative and Comparative Biology 44, no. 6 (December 2004): 443–49. https://doi.org/10.1093/icb/44.6.443.Full Text
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Nijhout, H Frederik, Michael C. Reed, Paula Budu, and Cornelia M. Ulrich. “A mathematical model of the folate cycle: new insights into folate homeostasis.” The Journal of Biological Chemistry 279, no. 53 (December 2004): 55008–16. https://doi.org/10.1074/jbc.m410818200.Full Text
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Yamanaka, Akira, H. F. Nijhout, L. W. Grunert, Yuichiro Suzuki, Chisato Kitazawa, and Katsuhiko Endo. “Neuroendocrine regulation of hair development in the ventral hind wing of Precis coenia.” Zoological Science 21, no. 12 (December 1, 2004): 1338–1338.Link to Item
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Yang, Andrew S., Christopher H. Martin, and H Frederik Nijhout. “Geographic variation of caste structure among ant populations.” Current Biology : Cb 14, no. 6 (March 2004): 514–19. https://doi.org/10.1016/j.cub.2004.03.005.Full Text
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Moczek, Armin P., and H Frederik Nijhout. “Trade-offs during the development of primary and secondary sexual traits in a horned beetle.” The American Naturalist 163, no. 2 (February 2004): 184–91. https://doi.org/10.1086/381741.Full Text
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Davidowitz, G., L. J. D’Amico, and H. Frederik Nijhout. “The effects of environmental variation on a mechanism that controls insect body size.” Evolutionary Ecology Research 6, no. 1 (January 1, 2004): 49–62.
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Reed, Michael C., H Frederik Nijhout, Rachel Sparks, and Cornelia M. Ulrich. “A mathematical model of the methionine cycle.” Journal of Theoretical Biology 226, no. 1 (January 2004): 33–43. https://doi.org/10.1016/j.jtbi.2003.08.001.Full Text
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Nijhout, H Frederik. “The control of growth.” Development (Cambridge, England) 130, no. 24 (December 2003): 5863–67. https://doi.org/10.1242/dev.00902.Full Text
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Nijhout, H Frederik. “Polymorphic mimicry in Papilio dardanus: mosaic dominance, big effects, and origins.” Evolution & Development 5, no. 6 (November 2003): 579–92. https://doi.org/10.1046/j.1525-142x.2003.03063.x.Full Text
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Nijhout, H. F. “On the association between genes and complex traits.” The Journal of Investigative Dermatology. Symposium Proceedings 8, no. 2 (October 2003): 162–63. https://doi.org/10.1046/j.1087-0024.2003.00801.x.Full Text
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Wheeler, Diana E., and H. F. Nijhout. “A perspective for understanding the modes of juvenile hormone action as a lipid signaling system.” Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology 25, no. 10 (October 2003): 994–1001. https://doi.org/10.1002/bies.10337.Full Text
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Nijhout, H. F. “The control of body size in insects.” Developmental Biology 261, no. 1 (September 2003): 1–9. https://doi.org/10.1016/s0012-1606(03)00276-8.Full Text
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Nijhout, H. F. “The importance of context in genetics.” American Scientist 91, no. 5 (September 1, 2003): 416–23. https://doi.org/10.1511/2003.5.416.Full Text
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Nijhout, H. F. “The importance of context in genetics - Genetic effects can be altered by their surroundings, and this determines the inheritance of traits such as flower color and the likelihood of cancer.” American Scientist 91, no. 5 (September 1, 2003): 416–23.Link to Item
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Nijhout, H Frederik, Philip K. Maini, Anotida Madzvamuse, Andrew J. Wathen, and Toshio Sekimura. “Pigmentation pattern formation in butterflies: experiments and models.” Comptes Rendus Biologies 326, no. 8 (August 2003): 717–27. https://doi.org/10.1016/j.crvi.2003.08.004.Full Text
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Moczek, Armin P., and H Frederik Nijhout. “Rapid evolution of a polyphenic threshold.” Evolution & Development 5, no. 3 (May 2003): 259–68. https://doi.org/10.1046/j.1525-142x.2003.03033.x.Full Text
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Nijhout, H. F., A. M. Berg, and W. T. Gibson. “A mechanistic study of evolvability using the mitogen-activated protein kinase cascade.” Evolution & Development 5, no. 3 (May 2003): 281–94. https://doi.org/10.1046/j.1525-142x.2003.03035.x.Full Text
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Davidowitz, Goggy, Louis J. D’Amico, and H Frederik Nijhout. “Critical weight in the development of insect body size.” Evolution & Development 5, no. 2 (March 2003): 188–97. https://doi.org/10.1046/j.1525-142x.2003.03026.x.Full Text
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Nijhout, H Frederik. “Development and evolution of adaptive polyphenisms.” Evolution & Development 5, no. 1 (January 2003): 9–18. https://doi.org/10.1046/j.1525-142x.2003.03003.x.Full Text
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Nijhout, H Frederik, and Laura W. Grunert. “Bombyxin is a growth factor for wing imaginal disks in Lepidoptera.” Proceedings of the National Academy of Sciences of the United States of America 99, no. 24 (November 2002): 15446–50. https://doi.org/10.1073/pnas.242548399.Full Text
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Moczek, Armin P., and H Frederik Nijhout. “Developmental mechanisms of threshold evolution in a polyphenic beetle.” Evolution & Development 4, no. 4 (July 2002): 252–64. https://doi.org/10.1046/j.1525-142x.2002.02014.x.Full Text
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Nijhout, H. F. “The nature of robustness in development.” Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology 24, no. 6 (June 2002): 553–63. https://doi.org/10.1002/bies.10093.Full Text
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Koch, P. B., and H. F. Nijhout. “The role of wing veins in colour pattern development in the butterfly Papilio xuthus (Lepidoptera: Papilionidae).” European Journal of Entomology 99, no. 1 (January 1, 2002): 67–72. https://doi.org/10.14411/eje.2002.012.Full Text
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Moczek, A. P., and H. F. Nijhout. “A method for sexing final instar larvae of the genus Onthophagus Latreille (Coleoptera: Scarabaeidae).” Coleopterists Bulletin 56, no. 2 (January 1, 2002): 279–84. https://doi.org/10.1649/0010-065X(2002)056[0279:AMFSFI]2.0.CO;2.Full Text
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Davidowitz, G., H. F. Nijhout, and L. J. D’Amico. “How is an insect the size that it is? How do physiological mechanisms change to produce genetic, environmental, and plasticity effects on body size?” American Zoologist 41, no. 6 (December 1, 2001): 1423–1423.Link to Item
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Nijhout, H. F. “Insect polyphenisms and adaptation.” American Zoologist 41, no. 6 (December 1, 2001): 1540–1540.Link to Item
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Browder, M. H., L. J. D’Amico, and H. F. Nijhout. “The role of low levels of juvenile hormone esterase in the metamorphosis of Manduca sexta.” Journal of Insect Science 1 (October 16, 2001): 1–4. https://doi.org/10.1673/031.001.1101.Full Text
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Nijhout, H. F. “Elements of butterfly wing patterns.” The Journal of Experimental Zoology 291, no. 3 (October 2001): 213–25. https://doi.org/10.1002/jez.1099.Full Text
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Emlen, D. J., and H. F. Nijhout. “Hormonal control of male horn length dimorphism in Onthophagus taurus (Coleoptera: Scarabaeidae): a second critical period of sensitivity to juvenile hormone.” Journal of Insect Physiology 47, no. 9 (September 2001): 1045–54. https://doi.org/10.1016/s0022-1910(01)00084-1.Full Text
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Gilchrist, M. A., and H. F. Nijhout. “Nonlinear developmental processes as sources of dominance.” Genetics 159, no. 1 (September 2001): 423–32. https://doi.org/10.1093/genetics/159.1.423.Full Text
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D’Amico, L. J., G. Davidowitz, and H. F. Nijhout. “The developmental and physiological basis of body size evolution in an insect.” Proceedings. Biological Sciences 268, no. 1476 (August 2001): 1589–93. https://doi.org/10.1098/rspb.2001.1698.Full Text
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Shafiei, M., A. P. Moczek, and H. F. Nijhout. “Food availability controls the onset of metamorphosis in the dung beetle Onthophagus taurus (Coleoptera: Scarabaeidae).” Physiological Entomology 26, no. 2 (July 11, 2001): 173–80. https://doi.org/10.1046/j.1365-3032.2001.00231.x.Full Text
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Browder, M. H., L. J. D’Amico, and H. F. Nijhout. “The role of low levels of juvenile hormone esterase in the metamorphosis of Manduca sexta.” Journal of Insect Science (Online) 1 (January 2001): 11.
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D’Amico, L. J., G. Davidowitz, and H. F. Nijhout. “Body size evolution in a laboratory strain of Manduca sexta: implications for studies in insect physiology and endocrinology.” American Zoologist 40, no. 6 (December 1, 2000): 988–89.Link to Item
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Emlen, D. J., and H. F. Nijhout. “The development and evolution of exaggerated morphologies in insects.” Annual Review of Entomology 45 (January 2000): 661–708. https://doi.org/10.1146/annurev.ento.45.1.661.Full Text
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McDonald, A. K., and H. F. Nijhout. “The effect of environmental conditions on mating activity of the Buckeye butterfly, Precis coenia.” J. Res. Lepidopt. 35, no. 22–28 (2000).
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Miner, D., D. AL, A. J. Rosenberg, and H. F. Nijhout. “Control of growth and differentiation of the wing imaginal disks of Precis coenia (Lepidoptera: Nymphalidae).” J. Insect Physiol. 46 (2000): 251–58.
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Nijhout, H. F. “When developmental pathways diverge.” Proceedings of the National Academy of Sciences of the United States of America 96, no. 10 (May 1999): 5348–50. https://doi.org/10.1073/pnas.96.10.5348.Full Text
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Weatherbee, S. D., H. F. Nijhout, L. W. Grunert, G. Halder, R. Galant, J. Selegue, and S. Carroll. “Ultrabithorax function in butterfly wings and the evolution of insect wing patterns.” Current Biology : Cb 9, no. 3 (February 1999): 109–15. https://doi.org/10.1016/s0960-9822(99)80064-5.Full Text
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Emlen, D. J., and H. F. Nijhout. “Hormonal control of male horn length dimorphism in the dung beetle Onthophagus taurus (Coleoptera: Scarabaeidae).” Journal of Insect Physiology 45, no. 1 (January 1999): 45–53. https://doi.org/10.1016/s0022-1910(98)00096-1.Full Text
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Klingenberg, C. P., and H. F. Nijhout. “Genetics of fluctuating asymmetry: A developmental model of developmental instability.” Evolution 53, no. 2 (1999): 358–75.
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Moczek, A. P., and H. F. Nijhout. “The evolution of polyphenic development and its consequences: Rapid allometric divergence between exotic populations of the scarab beetle Onthophagus taurus.” American Zoologist 39, no. 5 (January 1, 1999): 12A-12A.Link to Item
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Nijhout, H. F. “Control mechanisms of polyphenic development in insects: In polyphenic development, environmental factors alter some aspects of development in an orderly and predictable way.” Bioscience 49, no. 3 (January 1, 1999): 181–92. https://doi.org/10.2307/1313508.Full Text
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Nijhout, H. F. “Population genetics and microevolution developmental mechanisms.” American Zoologist 39, no. 5 (January 1, 1999): 14A-14A.Link to Item
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Klingenberg, C. P., and H. F. Nijhout. “Competition among growing organs and developmental control of morphological asymmetry.” Proceedings of the Royal Society B: Biological Sciences 265, no. 1401 (June 22, 1998): 1135–39. https://doi.org/10.1098/rspb.1998.0409.Full Text
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Weatherbee, S. D., G. Halder, R. Galant, J. Selegue, H. F. Nijhout, and S. Carroll. “Homeosis in a butterfly wing.” Developmental Biology 198, no. 1 (June 1, 1998): 199–199.Link to Item
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Nijhout, H. F., and C. Kremen. “Control of pupal commitment in the imaginal disks of Precis coenia (Lepidoptera: Nymphalidae).” Journal of Insect Physiology 44, no. 3–4 (March 1998): 287–96. https://doi.org/10.1016/s0022-1910(97)00121-2.Full Text
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Nijhout, H. F., and D. J. Emlen. “Competition among body parts in the development and evolution of insect morphology.” Proceedings of the National Academy of Sciences of the United States of America 95, no. 7 (March 1998): 3685–89. https://doi.org/10.1073/pnas.95.7.3685.Full Text
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Nijhout, H. F., and D. E. Wheeler. “Erratum: "Growth Models of Complex Allometries in Holometabolous Insects".” The American Naturalist 149, no. 3 (March 1, 1997): 606–606. https://doi.org/10.1086/286011.Full Text
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Nijhout, H. F. “Ommochrome Pigmentation of the linea and rosa Seasonal Forms of Precis coenia (Lepidoptera: Nymphalidae).” Archives of Insect Biochemistry and Physiology 36, no. 3 (January 1, 1997): 215–22. https://doi.org/10.1002/(SICI)1520-6327(1997)36:3<215::AID-ARCH5>3.0.CO;2-S.Full Text
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Nijhout, H. F., and S. M. Paulsen. “Developmental models and polygenic characters.” American Naturalist 149, no. 2 (January 1, 1997): 394–405. https://doi.org/10.1086/285996.Full Text
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Nijhout, H. F., and D. E. Wheeler. “Growth models of complex allometries in holometabolous insects.” American Naturalist 148, no. 1 (November 14, 1996): 40–56. https://doi.org/10.1086/285910.Full Text
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Nijhout, H. F. “Focus on butterfly eyespot development.” Nature 384, no. 6606 (November 1996): 209–10. https://doi.org/10.1038/384209a0.Full Text
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Nijhout, H. F., and D. B. Rountree. “Pattern induction across a homeotic boundary in the wings of Precis coenia (Hbn.) (Lepidoptera: Nymphalidae).” International Journal of Insect Morphology and Embryology 24, no. 3 (January 1, 1995): 243–51. https://doi.org/10.1016/0020-7322(95)00004-N.Full Text
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Rountree, D. B., and H. F. Nijhout. “Genetic control of a seasonal morph in Precis coenia (Lepidoptera: Nymphalidae).” Journal of Insect Physiology 41, no. 12 (January 1, 1995): 1141–45. https://doi.org/10.1016/0022-1910(95)00051-U.Full Text
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Rountree, D. B., and H. F. Nijhout. “Hormonal control of a seasonal polyphenism in Precis coenia (Lepidoptera: Nymphalidae).” Journal of Insect Physiology 41, no. 11 (January 1, 1995): 987–92. https://doi.org/10.1016/0022-1910(95)00046-W.Full Text
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Nijhout, H. F. “Symmetry systems and compartments in Lepidopteran wings: The evolution of a patterning mechanism.” Development 120, no. SUPPL. (December 1, 1994): 225–33.
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Nijhout, H. F. “Genes on the wing.” Science (New York, N.Y.) 265, no. 5168 (July 1994): 44–45. https://doi.org/10.1126/science.7912450.Full Text
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Nijhout, H. F. “Developmental perspectives on evolution of butterfly mimicry. Recent insights into development of color patterns have led to a simpler, more complete view of butterfly genetics.” Bioscience 44, no. 3 (January 1, 1994): 148–57. https://doi.org/10.2307/1312251.Full Text
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Paulsen, Susan M., and H Frederik Nijhout. “PHENOTYPIC CORRELATION STRUCTURE AMONG ELEMENTS OF THE COLOR PATTERN IN PRECIS COENIA (LEPIDOPTERA: NYMPHALIDAE).” Evolution; International Journal of Organic Evolution 47, no. 2 (April 1993): 593–618. https://doi.org/10.1111/j.1558-5646.1993.tb02115.x.Full Text
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Paulsen, Susan M., and H Frederik Nijhout. “Phenotypic Correlations Structure among Elements of the Color Pattern in Precis coenia (Lepidoptera: Nymphalidae).” Evolution 47, no. 2 (April 1993): 593–593. https://doi.org/10.2307/2410073.Full Text
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NIJHOUT, H. F. “ITERATION AND SYMMETRY.” South Atlantic Quarterly 90, no. 1 (1991): 61–86.Link to Item
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PAULSEN, S. M., and H. F. NIJHOUT. “PHENOTYPIC CORRELATIONS AMONG ELEMENTS OF THE COLOR PATTERN IN PRECIS-COENIA (LEPIDOPTERA, NYMPHALIDAE).” American Zoologist 31, no. 5 (January 1, 1991): A49–A49.Link to Item
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Nijhout, H. F. “Metaphors and the role of genes in development.” Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology 12, no. 9 (September 1990): 441–46. https://doi.org/10.1002/bies.950120908.Full Text
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Koch, P Bernhardt, and H Frederik Nijhout. “Color pattern specific proteins in black scales in developing wings ofPrecis coenia Hübner (Nymphalidae, Lepidoptera).” Roux’S Archives of Developmental Biology : The Official Organ of the Edbo 199, no. 5 (May 1990): 289–94. https://doi.org/10.1007/bf01709507.Full Text
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NIJHOUT, H. F., G. A. WRAY, and L. E. GILBERT. “An analysis of the phenotypic effects of certain colour pattern genes in Heliconius (Lepidoptera: Nymphalidae).” Biological Journal of the Linnean Society 40, no. 4 (January 1, 1990): 357–72. https://doi.org/10.1111/j.1095-8312.1990.tb00545.x.Full Text
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Nijhout, H. F. “A comprehensive model for colour pattern formation in butterflies.” Proceedings of the Royal Society B: Biological Sciences 239, no. 1294 (January 1, 1990): 81–113. https://doi.org/10.1098/rspb.1990.0009.Full Text
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Kremen, C., and H. F. Nijhout. “Juvenile hormone controls the onset of pupal commitment in the imaginal disks and epidermis of Precis coenia (Lepidoptera: Nymphalidae).” Journal of Insect Physiology 35, no. 8 (January 1, 1989): 603–12. https://doi.org/10.1016/0022-1910(89)90122-4.Full Text
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Nijhout, H Frederik. “In formation.” Nature 334, no. 6184 (August 1988): 660–660. https://doi.org/10.1038/334660b0.Full Text
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NIJHOUT, H. F., and G. A. WRAY. “Homologies in the colour patterns of the genus Heliconius (Lepidoptera: Nymphalidae).” Biological Journal of the Linnean Society 33, no. 4 (January 1, 1988): 345–65. https://doi.org/10.1111/j.1095-8312.1988.tb00449.x.Full Text
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Nijhout, H. F., and L. W. Grunert. “Colour pattern regulation after surgery on the wing disks of Precis coenia (Lepidoptera: Nymphalidae).” Development 102, no. 2 (January 1, 1988): 377–85.
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Nijhout, H Frederik. “Pattern and Pattern Diversity on Lepidopteran Wings.” Bioscience 36, no. 8 (September 1986): 527–33. https://doi.org/10.2307/1310154.Full Text
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Frederik Nijhout, H., G. A. Wray, C. Kremen, and C. K. Teragawa. “Ontogeny, phylogeny and evolution of form: An algorithmic approach.” Systematic Zoology 35, no. 4 (January 1, 1986): 445–57. https://doi.org/10.2307/2413108.Full Text
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Nijhout, H. F., and G. A. Wray. “Homologies in the colour patterns of the genus Charaxes (Lepidoptera: Nymphalidae).” Biological Journal of the Linnean Society 28, no. 4 (January 1, 1986): 387–410. https://doi.org/10.1111/j.1095-8312.1986.tb01766.x.Full Text
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Nijhout, H. F. “Cautery-induced colour patterns in Precis coenia (Lepidoptera: Nymphalidae).” Journal of Embryology and Experimental Morphology 86 (April 1985): 191–203.
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Nijhout, H. F. “Independent development of homologous pattern elements in the wing patterns of butterflies.” Developmental Biology 108, no. 1 (March 1985): 146–51. https://doi.org/10.1016/0012-1606(85)90016-8.Full Text
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KREMEN, C., and H. F. NIJHOUT. “DEFINING COMMITMENT AND COMPETENCE IN LEPIDOPTERAN IMAGINAL DISKS BY HORMONAL TREATMENT.” American Zoologist 25, no. 4 (January 1, 1985): A62–A62.Link to Item
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Nijhout, H. F. “The Developmental Physiology of Color Patterns in Lepidoptera.” Advances in Insect Physiology 18, no. C (January 1, 1985): 181–247. https://doi.org/10.1016/S0065-2806(08)60041-7.Full Text
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Nijhout, H. F. “Colour pattern modification by coldshock in Lepidoptera.” Journal of Embryology and Experimental Morphology 81 (June 1984): 287–305.
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Nijhout, H. F. “Abdominal stretch reception in Dipetalogaster maximus (Hemiptera: Reduviidae).” Journal of Insect Physiology 30, no. 8 (January 1, 1984): 629–33. https://doi.org/10.1016/0022-1910(84)90047-7.Full Text
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Wheeler, D. E., and H. Frederik Nijhout. “Soldier determination in Pheidole bicarinata: Inhibition by adult soldiers.” Journal of Insect Physiology 30, no. 2 (January 1, 1984): 127–35. https://doi.org/10.1016/0022-1910(84)90116-1.Full Text
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Nijhout, H. F. “Definition of a juvenile hormone-sensitive period in Rhodnius prolixus.” Journal of Insect Physiology 29, no. 9 (January 1, 1983): 669–77. https://doi.org/10.1016/0022-1910(83)90041-0.Full Text
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Smith, W. A., and H. F. Nijhout. “In vitro stimulation of cell death in the moulting glands of Oncopeltus fasciatus by 20-hydroxyecdysone.” Journal of Insect Physiology 29, no. 2 (January 1, 1983). https://doi.org/10.1016/0022-1910(83)90141-5.Full Text
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Wheeler, D. E., and H. Frederik Nijhout. “Soldier determination in Pheidole bicarinata: Effect of methoprene on caste and size within castes.” Journal of Insect Physiology 29, no. 11 (January 1, 1983): 847–54. https://doi.org/10.1016/0022-1910(83)90151-8.Full Text
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Nijhout, H. F., and D. E. Wheeler. “Juvenile hormone and the physiological basis of insect polymorphisms.” Quarterly Review of Biology 57, no. 2 (January 1, 1982): 109–33. https://doi.org/10.1086/412671.Full Text
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Smith, W. A., and H. F. Nijhout. “Ultrastructural changes accompanying secretion and cell death in the molting glands of an insect (Oncopeltus).” Tissue & Cell 14, no. 2 (January 1982): 243–52. https://doi.org/10.1016/0040-8166(82)90022-2.Full Text
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Smith, W. A., and H. Frederik Nijhout. “Synchrony of juvenile hormone-sensitive periods for internal and external development in last-instar larvae of Oncopeltus fasciatus.” Journal of Insect Physiology 28, no. 9 (January 1, 1982). https://doi.org/10.1016/0022-1910(82)90141-X.Full Text
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Nijhout, H. F. “Physiological control of molting in insects.” Integrative and Comparative Biology 21, no. 3 (December 1, 1981): 631–40. https://doi.org/10.1093/icb/21.3.631.Full Text
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Wheeler, D. E., and H. F. Nijhout. “Soldier determination in ants: new role for juvenile hormone.” Science (New York, N.Y.) 213, no. 4505 (July 1981): 361–63. https://doi.org/10.1126/science.213.4505.361.Full Text
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Nijhout, H. F. “The color patterns of butterflies and moths.” Scientific American 245, no. 5 (January 1, 1981): 140–50. https://doi.org/10.1038/scientificamerican1181-140.Full Text
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Smith, W. A., and H. F. Nijhout. “Effects of a juvenile hormone analogue on the duration of the fifth instar in the milkweed bug Oncopeltus fasciatus.” Journal of Insect Physiology 27, no. 3 (January 1, 1981): 169–73. https://doi.org/10.1016/0022-1910(81)90124-4.Full Text
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WHEELER, D. E., and H. F. NIJHOUT. “SOLDIER DETERMINATION IN THE ANT PHEIDOLE-BICARINATA - EFFECTS OF A JUVENILE-HORMONE ANALOG ON CASTE AND SIZE WITHIN CASTES.” American Zoologist 21, no. 4 (January 1, 1981): 1028–1028.Link to Item
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Wheeler, D. E., and H. F. Nijhout. “Imaginal wing discs in larvae of the soldier caste of Pheidole bicarinata vinelandica Forel (Hymenoptera : Formicidae).” International Journal of Insect Morphology and Embryology 10, no. 2 (January 1, 1981): 131–39. https://doi.org/10.1016/S0020-7322(81)80018-9.Full Text
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Nijhout, H. F. “Pattern formation on lepidopteran wings: determination of an eyespot.” Developmental Biology 80, no. 2 (December 1980): 267–74. https://doi.org/10.1016/0012-1606(80)90403-0.Full Text
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Nijhout, H. F. “Ontogeny of the color pattern on the wings of Precis coenia (Lepidoptera: Nymphalidae).” Developmental Biology 80, no. 2 (December 1980): 275–88. https://doi.org/10.1016/0012-1606(80)90404-2.Full Text
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NIJHOUT, H. F. “PHYSIOLOGICAL CONTROL OF PROTHORACICOTROPIC HORMONE-SECRETION.” American Zoologist 20, no. 4 (January 1, 1980): 760–760.Link to Item
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SMITH, W. A., and H. F. NIJHOUT. “JUVENILE-HORMONE REDUCES THE DURATION OF THE 5TH LARVAL INSTAR OF ONCOPELTUS-FASCIATUS.” American Zoologist 20, no. 4 (January 1, 1980): 899–899.Link to Item
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WHEELER, D. E., and H. F. NIJHOUT. “IMAGINAL WING DISKS IN WORKER LARVAE OF THE ANT, PHEIDOLE-BICARINATA-VINELANDICA.” American Zoologist 20, no. 4 (January 1, 1980): 878–878.Link to Item
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Nijhout, H. F., and H. G. Sheffield. “Antennal hair erection in male mosquitoes: a new mechanical effector in insects.” Science (New York, N.Y.) 206, no. 4418 (November 1979): 595–96. https://doi.org/10.1126/science.40308.Full Text
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Nijhout, H. F. “Stretch-induced moulting in Oncopeltus fasciatus.” Journal of Insect Physiology 25, no. 3 (January 1, 1979): 277–81. https://doi.org/10.1016/0022-1910(79)90055-6.Full Text
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SMITH, W. A., and H. F. NIJHOUT. “REGULATION OF METAMORPHIC CELL-DEATH IN THE MOLTING GLANDS OF ONCOPELTUS-FASCIATUS.” American Zoologist 19, no. 3 (January 1, 1979): 915–915.Link to Item
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Nijhout, H. F., and S. K. Martin. “Alpha-adrenergic activity of isoproterenol in mosquito antennae.” Experientia 34, no. 6 (June 1, 1978): 758–59. https://doi.org/10.1007/BF01947307.Full Text
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NIJHOUT, H. F. “STRETCH-INDUCED MOLTING IN ONCOPELTUS-FASCIATUS (HEMIPTERA LYGAEIDAE).” American Zoologist 18, no. 3 (January 1, 1978): 625–625.Link to Item
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Nijhout, H. F. “Wing pattern formation in Lepidoptera: A model.” Journal of Experimental Zoology 206, no. 2 (January 1, 1978): 119–36. https://doi.org/10.1002/jez.1402060202.Full Text
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Nijhout, H. F., and G. M. Carrow. “Diuresis after a bloodmeal in female Anopheles freeborni.” Journal of Insect Physiology 24, no. 4 (January 1, 1978): 293–98. https://doi.org/10.1016/0022-1910(78)90025-2.Full Text
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NIJHOUT, H F. R. E. D. E. R. I. K. “CONTROL OF ANTENNAL HAIR ERECTION IN MALE MOSQUITOES.” The Biological Bulletin 153, no. 3 (December 1977): 591–603. https://doi.org/10.2307/1540608.Full Text
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Frederik Nijhout, H. “The rôle of ecdysone in pupation of Manduca sexta.” Journal of Insect Physiology 22, no. 3 (January 1, 1976). https://doi.org/10.1016/0022-1910(76)90017-2.Full Text
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Nijhout, H. F. “The rôle of ecdysone in pupation of Manduca sexta.” Journal of Insect Physiology 22, no. 3 (1976): 453–63.
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Nijhout, H. F. “Dynamics of juvenile hormone action in larvae of the tobacco hornworm, Manduca sexta (L.).” The Biological Bulletin 149, no. 3 (December 1975): 568–79. https://doi.org/10.2307/1540387.Full Text
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Nijhout, H. F. “A threshold size for metamorphosis in the tobacco hornworm, Manduca sexta (L.).” The Biological Bulletin 149, no. 1 (August 1975): 214–25. https://doi.org/10.2307/1540491.Full Text
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Nijhout, H. F. “Excretory role of the midgut in larvae of the tobacco hornworm, Manduca sexta (L.).” The Journal of Experimental Biology 62, no. 1 (February 1975): 221–30. https://doi.org/10.1242/jeb.62.1.221.Full Text
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Frederik Nijhout, H. “Axonal pathways in the brain-retrocerebral neuroendocrine complex of Manduca sexta (L.) (Lepidoptera: Sphingidae).” International Journal of Insect Morphology and Embryology 4, no. 6 (January 1, 1975): 529–38. https://doi.org/10.1016/0020-7322(75)90029-X.Full Text
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Hausermann, W., and H. F. Nijhout. “Permanent loss of male fecundity following sperm depletion in Aedes aegypti (L.).” Journal of Medical Entomology 11, no. 6 (January 1975): 707–15. https://doi.org/10.1093/jmedent/11.6.707.Full Text
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Nijhout, H. F., and C. M. Williams. “Control of moulting and metamorphosis in the tobacco hornworm, Manduca sexta (L.): growth of the last-instar larva and the decision to pupate.” The Journal of Experimental Biology 61, no. 2 (October 1974): 481–91. https://doi.org/10.1242/jeb.61.2.481.Full Text
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Nijhout, H. F., and C. M. Williams. “Control of moulting and metamorphosis in the tobacco hornworm, Manduca sexta (L.): cessation of juvenile hormone secretion as a trigger for pupation.” The Journal of Experimental Biology 61, no. 2 (October 1974): 493–501. https://doi.org/10.1242/jeb.61.2.493.Full Text
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NIJHOUT, H. F., and G. B. CRAIG. “REPRODUCTIVE ISOLATION IN STEGOMYIA MOSQUITOES. III EVIDENCE FOR A SEXUAL PHEROMONE.” Entomologia Experimentalis Et Applicata 14, no. 4 (January 1, 1971): 399–412. https://doi.org/10.1111/j.1570-7458.1971.tb00178.x.Full Text
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Reed, M. C., William Duncan, H. F. Nijhout, J. Best, and M. Golubitsky. “Homeostasis Despite Instability (Submitted).” Mathematical Biosciences, n.d.Open Access Copy
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Reed, Michael, Frederik Nijhout, and Ruby Kim. “One-carbon metabolism during the menstrual cycle and pregnancy.” Plos Computational Biology (to appear) (n.d.).Open Access Copy
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Book Sections
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Nijhout, H Frederik, Anna M. Kudla, and Caleb C. Hazelwood. “Genetic assimilation and accommodation: Models and mechanisms.,” 141:337–69, 2021. https://doi.org/10.1016/bs.ctdb.2020.11.006.Full Text
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Suzuki, Y., K. Z. McKenna, and H Frederik Nijhout. “Regulation of phenotypic plasticity from the perspective of evolutionary developmental biology.” In Phenotypic Switching Implications in Biology and Medicine, edited by H. Levine, M. K. Jolly, and V. Nanjundiah, 403–403. Academic Press, 2020.
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Nijhout, H Frederik, and Emily Laub. “The role of hormones.” Oxford University Press, 2018. https://doi.org/10.1093/oso/9780198797500.003.0004.Full Text
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Nijhout, H. F. “Pattern and process.” In Pattern Formation in the Physical and Biological Sciences, 1–12, 2018. https://doi.org/10.1201/9780429493362.Full Text
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Nijhout, H. F. “The common developmental origin of eyespots and parafocal elements and a new model mechanism for color pattern formation.” In Diversity and Evolution of Butterfly Wing Patterns: An Integrative Approach, 3–19, 2017. https://doi.org/10.1007/978-981-10-4956-9_1.Full Text
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Brandon, R. N., and H. F. Nijhout. “The Empirical Nonequivalence of Genic and Genotypic Models of Selection: A (Decisive) Refutation of Genic Selectionism and Pluralistic Genic Selectionism.” In Philosophy of Evolutionary Biology: Volume I, 383–404, 2017.
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Reed, M. C., J. Best, and H. F. Nijhout. “Mathematical models of neuromodulation and implications for neurology and psychiatry (Accepted).” In Computational Neurology and Psychiatry, edited by P. Erdi, B. Bhattacharya, and A. Cochran. New York: Springer, 2017.
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Reed, M. C., H. F. Nijhout, and T. Kurtz. “Mathematical modeling of cell metabolism.” In Encyclopedia of Applied and Computational Mathematics, edited by B. Engquist. New York: Springer, 2016.
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Nijhout, H. F. “A Developmental-Physiological Perspective on the Development and Evolution of Phenotypic Plasticity.” In Boston Studies in the Philosophy and History of Science, 307:147–73, 2015. https://doi.org/10.1007/978-94-017-9412-1_7.Full Text
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Reed, M. C., J. Best, H. F. Nijhout, and G. Oakley. “Mathematical models: Interactions between serotonion and dopamine in Parkinson's disease.” In Etiology and Pathophysiology of Parkinson’s Disease, edited by A. Q. Rana. InTech Pub., 2011.
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Reed, M. C., H. F. Nijhout, and C. Ulrich. “Mathematical Models of One-Carbon Metabolism.” In Vitamins and Hormones, Volume 79, edited by G. Litvack, 42–85. Amsterdam NE: Elsevier, 2008.
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Conference Papers
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He, L. L., S. H. Shin, Z. Wang, I. Yuan, R. Weschler, A. Chiou, T. Koyama, H. F. Nijhout, and Y. Suzuki. “How caterpillars assess size: The role of the TGF-beta/Activin ligand Myoglianin in triggering metamorphosis.” In Integrative and Comparative Biology, 61:E364–65, 2021.Link to Item
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Davis, A. L., H. F. Nijhout, and S. Johnsen. “Convergent evolution of ultra-black butterfly scales.” In Integrative and Comparative Biology, 60:E53–E53, 2020.Link to Item
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He, L., S. H. J. Shin, Z. Wang, I. Yuan, R. Weschler, T. Koyama, H. F. Nijhout, and Y. Suzuki. “Body size sensing in the tobacco hornworm, Manduca sexta: the role of TGF-beta/Activin signaling in metamorphic timing.” In Integrative and Comparative Biology, 60:E98–E98, 2020.Link to Item
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Kudla, A. M., and H. F. Nijhout. “Sources of Treehopper Pronotal Variability: An Exploration of Evolutionary Potential in Entylia carinata.” In Integrative and Comparative Biology, 60:E361–E361, 2020.Link to Item
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McKenna, Kenneth Z., Della Tao, and H Frederik Nijhout. “Exploring the Role of Insulin Signaling in Relative Growth: A Case Study on Wing-Body Scaling in Lepidoptera.” In Integrative and Comparative Biology, 59:1324–37, 2019. https://doi.org/10.1093/icb/icz080.Full Text
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Palmer, Rayleigh, Kenneth Z. McKenna, and H. F. Nijhout. “Morphological Murals: The Scaling and Allometry of Butterfly Wing Patterns.” In Integrative and Comparative Biology, 59:1281–89, 2019. https://doi.org/10.1093/icb/icz123.Full Text
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Johnsen, S., and H. F. Nijhout. “Super-black butterfly uses stealth technology: honeycomb absorbing structures in the scales of the wings of Trogonoptera brookiana.” In Integrative and Comparative Biology, 59:E112–E112. OXFORD UNIV PRESS INC, 2019.Link to Item
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Mckenna, K. Z., and H. F. Nijhout. “The impact of protein malnutrition on growth and scaling in the rat Rattus norvegicus.” In Integrative and Comparative Biology, 58:E151–E151. OXFORD UNIV PRESS INC, 2018.Link to Item
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Nijhout, H Frederik, and Kenneth Z. McKenna. “The Origin of Novelty Through the Evolution of Scaling Relationships.” In Integrative and Comparative Biology, 57:1322–33, 2017. https://doi.org/10.1093/icb/icx049.Full Text
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Gawne, R., and H. F. Nijhout. “Phenotypic variation and aposematic signaling in an arctiid moth (Utetheisa ornatrix).” In Integrative and Comparative Biology, 57:E269–E269. OXFORD UNIV PRESS INC, 2017.Link to Item
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Mckenna, K. Z., and H. F. Nijhout. “Allometry and Reaction Norms: Wing-Body Scaling in Manduca sexta.” In Integrative and Comparative Biology, 57:E110–E110. OXFORD UNIV PRESS INC, 2017.Link to Item
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Thanacoody, HK Ruben, H Fred Nijhout, Mike C. Reed, and Simon Thomas. “Mathematical modeling of the effect of different intravenous acetylcysteine regimens on hepatic glutathione regeneration and hepatocyte death following simulated acetaminophen overdose.” In Clinical Toxicology, 55:753–753. TAYLOR & FRANCIS LTD, 2017.Link to Item
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Thanacoody, HK Ruben, H Fred Nijhout, Mike C. Reed, and Simon Thomas. “Mathematical modeling of the effect of late administration of a novel acetylcysteine regimen based on the SNAP trial on hepatic glutathione regeneration and hepatocyte death following simulated acetaminophen overdose.” In Clinical Toxicology, 55:753–54. TAYLOR & FRANCIS LTD, 2017.Link to Item
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Nijhout, H. F., and M. C. Reed. “Homeostasis and dynamic stability of the phenotype: Implications for understanding the nature and evolution of robustness and plasticity.” In Integrative and Comparative Biology, 54:E153–E153. OXFORD UNIV PRESS INC, 2014.Link to Item
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Jalli, I. S., and H. F. Nijhout. “Physiological response to homocysteine stress in Escherichia coli.” In Integrative and Comparative Biology, 52:E269–E269. OXFORD UNIV PRESS INC, 2012.Link to Item
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Nijhout, H. F. “Phenotypic Plasticity and Allometry: New Models and Evolutionary Implications.” In Integrative and Comparative Biology, 52:E129–E129. OXFORD UNIV PRESS INC, 2012.Link to Item
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Rios-Avila, Luisa, H Frederik Nijhout, Michael C. Reed, Harry S. Sitren, and Jesse F. Gregory. “Mathematical model gives insights into vitamin B6 and kynurenine metabolism.” In Faseb Journal, Vol. 26. FEDERATION AMER SOC EXP BIOL, 2012.Link to Item
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Callier, V., and H. F. Nijhout. “Respiratory physiology and the initiation of molting in the tobacco hornworm, Manduca sexta.” In Integrative and Comparative Biology, 51:E20–E20. OXFORD UNIV PRESS INC, 2011.Link to Item
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Jalli, I. S., and H. F. Nijhout. “Stabilization of Escherichia coli Methionine Cycle Upon Simulated Insertion of Arabidopsis Thaliana MMT Enzyme.” In Integrative and Comparative Biology, 51:E206–E206. OXFORD UNIV PRESS INC, 2011.Link to Item
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Conti, D. V., J. C. Figueiredo, A. J. Levine, C. M. Ulrich, J. N. Poynter, H. F. Nijhout, M. Reed, Y. Zheng, and R. W. Haile. “Using in silico priors for pathway modeling.” In Genetic Epidemiology, 32:669–669. WILEY-LISS, 2008.Link to Item
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Davidowitz, G., D. A. Roff, and H. F. Nijhout. “The physiological regulation of simultaneously selected life history traits.” In Integrative and Comparative Biology, 45:984–984. OXFORD UNIV PRESS INC, 2005.Link to Item
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Davidowitz, G., D. A. Roff, and H. F. Nijhout. “The physiological regulation of the response to simultaneous selection on body size and development time in Manduca sexta.” In Integrative and Comparative Biology, 43:974–974. SOC INTEGRATIVE COMPARATIVE BIOLOGY, 2003.Link to Item
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Davidowitz, G., and H. F. Nijhout. “The physiological basis of reaction norms: Where developmental rate and duration of development connect.” In Integrative and Comparative Biology, 43:841–841. SOC INTEGRATIVE COMPARATIVE BIOLOGY, 2003.Link to Item
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Nijhout, H. F. “Gradients, diffusion, and genes in pattern formation.” In Origination of Organismal Form, edited by G. B. Muller and S. A. Newman, 165–81. MIT PRESS, 2003.Link to Item
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Davidowitz, G., L. J. D’Amico, D. A. Roff, and H. F. Nijhout. “The physiological regulation of insect body size.” In Integrative and Comparative Biology, 42:1217–1217. SOC INTEGRATIVE COMPARATIVE BIOLOGY, 2002.Link to Item
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NIJHOUT, H. F. “PATTERN-FORMATION IN BIOLOGICAL-SYSTEMS.” In 1991 Lectures in Complex Systems, edited by L. Nadel and D. Stein, 4:159–87. ADDISON-WESLEY PUBL CO, 1992.Link to Item
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Exhibitions, Screenings, & Performances
- Teaching & Mentoring
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Recent Courses
- BIOLOGY 293: Research Independent Study 2023
- BIOLOGY 454S: Physiological Genetics of Disease 2023
- BIOLOGY 293: Research Independent Study 2022
- BIOLOGY 454S: Physiological Genetics of Disease 2022
- BIOLOGY 792: Research 2022
- BIOLOGY 293: Research Independent Study 2021
- BIOLOGY 454S: Physiological Genetics of Disease 2021
- BIOLOGY 493: Research Independent Study 2021
- BIOLOGY 547L: Entomology 2021
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Advising & Mentoring
- I host 2-4 undergraduate students dolng independent projects in my lab every semester. Almost every year, one of these develops their project as a honors thesis. In recent years, more than 65% of undergraduates have been women. In the past 7 years, 11 of these undergraduates have been co-authors on 13 papers published in the peer-reviewed literature.
- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
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Service to the Profession
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