https://orcid.org/0000-0001-9078-845X
Current Appointments & Affiliations
Professor of Biostatistics & Bioinformatics
·
2023 - Present
Biostatistics & Bioinformatics, Division of Biostatistics,
Biostatistics & Bioinformatics
Member in the Duke Clinical Research Institute
·
2020 - Present
Duke Clinical Research Institute,
Institutes and Centers
Recent Publications
Genotype-Guided Antidepressant Prescribing for Patients With Depression: A Randomized Clinical Trial.
Journal Article JAMA Netw Open · May 1, 2026 IMPORTANCE: The effectiveness of pharmacogenetics to guide prescribing of selective serotonin reuptake inhibitors (SSRIs) for depression remains unclear, despite the well-established association between SSRI pharmacokinetics and genetic variation. OBJECTIV ... Full text Link to item CiteTREATment of Lower Respiratory Tract Infection in Selected Hospitals in Southern Sri Lanka (TREAT-SL): study protocol for a stepped-wedge, cluster-randomized clinical trial.
Journal Article Trials · March 18, 2026 BACKGROUND: Lower respiratory tract infection (LRTI) is a leading cause of hospitalization and antibacterial use globally. In low- and middle-income countries (LMICs), limited diagnostic resources contribute to inappropriate antibacterial use for LRTI. The ... Full text Link to item CiteGenetic Testing for APOL1 in Adults With Hypertension: The GUARDD-US Randomized Clinical Trial.
Journal Article JAMA Netw Open · March 2, 2026 IMPORTANCE: Apolipoprotein L1 locus (APOL1) high-risk alleles are associated with incidence of chronic kidney disease (CKD) among people with African ancestry. Few studies have examined the effect of genetic return of results on blood pressure (BP) managem ... Full text Link to item CiteRecent Grants
2/2 Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFPEF)
ResearchPrincipal Investigator · Awarded by National Heart, Lung, and Blood Institute · 2024 - 2028A randomized controlled trial of a novel, evidence-based algorithm for managing lower respiratory tract infection in a resource-limited setting
ResearchCollaborator · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 20272/2: Implementation of the American College of Physician guideline for low back pain using a Multidisciplinary Conservative Care (MC2) model at the initial point of patient contact: A cluster randomized trial (IMPACt-LBP)-DCC
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2027View All Grants
Education
University of North Carolina, Chapel Hill ·
2000
Ph.D.