Hussein Rashid Al-Khalidi

Hussein Rashid Al-Khalidi
Professor of Biostatistics & Bioinformatics

My research interest includes design and analysis of cardiovascular clinical trials, medical devices, survival analysis, group-sequential analysis, time-to-recurrent or multiple events, continuous-time Markov models, stochastic process, linear model, dose-response modeling, design of experiments and adaptive designs.

Current Appointments & Affiliations

Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2021
Membership in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2010

Contact Information

200 Morris Street, 6830 200 Morris Street, Durham, NC 27701
Duke Box 3850, Durham, NC 27710
hussein.al-khalidi@duke.edu (919) 668-2923

Background
Education, Training, & Certifications
- Ph.D., Texas A&M University 1988
Previous Appointments & Affiliations
- Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2020
- Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2010 - 2020
Research
Selected Grants
- DCC: Regional Approaches to Cardiovascular Emergencies- Cardiac ARreSt (RACE-CARS) Cluster-Randomized Trial 2/2 awarded by National Institutes of Health 2020 - 2027
- Urinary Stone Disease Research Network: Scientific Data Research Center awarded by National Institutes of Health 2016 - 2024
- Postdoctoral Training in Cardiovascular Clinical Research awarded by National Institutes of Health 2013 - 2024
- STICHES awarded by National Institutes of Health 2011 - 2019
- PROMISE Substudy to Assess For Effective dose of Radiation (PROMISE-SAFER) awarded by Columbia University 2011 - 2018
- Heart Rescue Flagship Premier Partner Program "RACE CARs" awarded by Medtronic Foundation 2013 - 2017
- Claret Sentinel System Statistical Analysis awarded by Claret Medical, Inc. 2016 - 2017
- HeartRescue awarded by University of Washington 2016 - 2017
- CABANA-AF Trial awarded by National Institutes of Health 2009 - 2017
- PROMISE Trial: SDCC awarded by National Institutes of Health 2009 - 2015
- ICD Therapy in Patients with Congestive Heart Failure awarded by National Institutes of Health 2009 - 2014
External Relationships
- CSL Behring LLC
- Medpace, Inc.
- National Institutes of Health
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Monahan, Kristi H., T Jared Bunch, Daniel B. Mark, Jeanne E. Poole, Tristram D. Bahnson, Hussein R. Al-Khalidi, Adam P. Silverstein, et al. “Influence of atrial fibrillation type on outcomes of ablation vs. drug therapy: results from CABANA.” Europace, May 31, 2022. https://doi.org/10.1093/europace/euac055.
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  - Wang, Shijie, Shakthi Unnithan, Nicole Bryant, Allison Chang, Liana S. Rosenthal, Alexander Pantelyat, Ted M. Dawson, Hussein R. Al-Khalidi, and Andrew B. West. “Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease.” Mov Disord, May 6, 2022. https://doi.org/10.1002/mds.29043.
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  - Pokorney, Sean D., Noelle Cocoros, Hussein R. Al-Khalidi, Kevin Haynes, Shuang Li, Sana M. Al-Khatib, Jacqueline Corrigan-Curay, et al. “Effect of Mailing Educational Material to Patients With Atrial Fibrillation and Their Clinicians on Use of Oral Anticoagulants: A Randomized Clinical Trial.” Jama Netw Open 5, no. 5 (May 2, 2022): e2214321. https://doi.org/10.1001/jamanetworkopen.2022.14321.
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  - Granger, Bradi B., Lisa A. Kaltenbach, Gregg C. Fonarow, Larry A. Allen, David E. Lanfear, Nancy M. Albert, Hussein R. Al-Khalidi, et al. “Health System-Level Performance in Prescribing Guideline-Directed Medical Therapy for Patients With Heart Failure With Reduced Ejection Fraction: Results From the CONNECT-HF Trial.” J Card Fail, April 22, 2022. https://doi.org/10.1016/j.cardfail.2022.03.356.
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  - Harper, Jonathan D., Alana C. Desai, Jodi A. Antonelli, Gregory E. Tasian, Justin B. Ziemba, Hussein R. Al-Khalidi, H Henry Lai, et al. “Quality of life impact and recovery after ureteroscopy and stent insertion: insights from daily surveys in STENTS.” Bmc Urol 22, no. 1 (April 6, 2022): 53. https://doi.org/10.1186/s12894-022-01004-9.
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  - Haeusler, Karl Georg, Felizitas A. Eichner, Peter U. Heuschmann, Jochen B. Fiebach, Tobias Engelhorn, Benjamin Blank, David Callans, et al. “MRI-Detected Brain Lesions and Cognitive Function in Patients With Atrial Fibrillation Undergoing Left Atrial Catheter Ablation in the Randomized AXAFA-AFNET 5 Trial.” Circulation 145, no. 12 (March 22, 2022): 906–15. https://doi.org/10.1161/CIRCULATIONAHA.121.056320.
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  - Bahnson, Tristram D., Anna Giczewska, Daniel B. Mark, Andrea M. Russo, Kristi H. Monahan, Hussein R. Al-Khalidi, Adam P. Silverstein, et al. “Association Between Age and Outcomes of Catheter Ablation Versus Medical Therapy for Atrial Fibrillation: Results From the CABANA Trial.” Circulation 145, no. 11 (March 15, 2022): 796–804. https://doi.org/10.1161/CIRCULATIONAHA.121.055297.
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  - Chew, Derek S., Patricia A. Cowper, Hussein Al-Khalidi, Kevin J. Anstrom, Melanie R. Daniels, Linda Davidson-Ray, Yanhong Li, et al. “Cost-Effectiveness of Coronary Artery Bypass Surgery Versus Medicine in Ischemic Cardiomyopathy: The STICH Randomized Clinical Trial.” Circulation 145, no. 11 (March 15, 2022): 819–28. https://doi.org/10.1161/CIRCULATIONAHA.121.056276.
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  - Nanna, Michael G., Sreekanth Vemulapalli, Christopher B. Fordyce, Daniel B. Mark, Manesh R. Patel, Hussein R. Al-Khalidi, Michelle Kelsey, et al. “The prospective randomized trial of the optimal evaluation of cardiac symptoms and revascularization: Rationale and design of the PRECISE trial.” Am Heart J 245 (March 2022): 136–48. https://doi.org/10.1016/j.ahj.2021.12.004.
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  - Raja, Shruti M., Jeffrey T. Guptill, Alec McConnell, Hussein R. Al-Khalidi, Matthew G. Hartwig, and Jacob A. Klapper. “Perioperative Outcomes of Thymectomy in Myasthenia Gravis: A Thoracic Surgery Database Analysis.” Ann Thorac Surg 113, no. 3 (March 2022): 904–10. https://doi.org/10.1016/j.athoracsur.2021.06.071.
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  - Doenst, Torsten, Haissam Haddad, Amanda Stebbins, James A. Hill, Eric J. Velazquez, Kerry L. Lee, Jean L. Rouleau, et al. “Renal function and coronary bypass surgery in patients with ischemic heart failure.” J Thorac Cardiovasc Surg 163, no. 2 (February 2022): 663-672.e3. https://doi.org/10.1016/j.jtcvs.2020.02.136.
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  - Nelson, Adam J., Emily C. O’Brien, Lisa A. Kaltenbach, Jennifer B. Green, Renato D. Lopes, Caryn G. Morse, Hussein R. Al-Khalidi, et al. “Use of Lipid-, Blood Pressure-, and Glucose-Lowering Pharmacotherapy in Patients With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease.” Jama Netw Open 5, no. 2 (February 1, 2022): e2148030. https://doi.org/10.1001/jamanetworkopen.2021.48030.
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  - Urinary Stone Disease Research Network (USDRN) Investigators, Douglas L. “Impact of COVID-19 on Prevention of Urinary Stones with Hydration (PUSH) Study: Challenges and Opportunities for Future Trials.” J Urol 206, no. 3 (September 2021): 502–4. https://doi.org/10.1097/JU.0000000000001833.
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  - DeVore, Adam D., Bradi B. Granger, Gregg C. Fonarow, Hussein R. Al-Khalidi, Nancy M. Albert, Eldrin F. Lewis, Javed Butler, et al. “Effect of a Hospital and Postdischarge Quality Improvement Intervention on Clinical Outcomes and Quality of Care for Patients With Heart Failure With Reduced Ejection Fraction: The CONNECT-HF Randomized Clinical Trial.” Jama 326, no. 4 (July 27, 2021): 314–23. https://doi.org/10.1001/jama.2021.8844.
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  - Thomas, Kevin L., Hussein R. Al-Khalidi, Adam P. Silverstein, Kristi H. Monahan, Tristram D. Bahnson, Jeanne E. Poole, Daniel B. Mark, Douglas L. Packer, and Douglas L. CABANA Investigators. “Ablation Versus Drug Therapy for Atrial Fibrillation in Racial and Ethnic Minorities.” J Am Coll Cardiol 78, no. 2 (July 13, 2021): 126–38. https://doi.org/10.1016/j.jacc.2021.04.092.
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  - Nelson, Adam J., Neha J. Pagidipati, Vanita R. Aroda, Matthew A. Cavender, Jennifer B. Green, Renato D. Lopes, Hussein Al-Khalidi, et al. “Incorporating SGLT2i and GLP-1RA for Cardiovascular and Kidney Disease Risk Reduction: Call for Action to the Cardiology Community.” Circulation 144, no. 1 (July 6, 2021): 74–84. https://doi.org/10.1161/CIRCULATIONAHA.121.053766.
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  - Scales, Charles D., Alana C. Desai, Jonathan D. Harper, H Henry Lai, Naim M. Maalouf, Peter P. Reese, Gregory E. Tasian, et al. “Prevention of Urinary Stones With Hydration (PUSH): Design and Rationale of a Clinical Trial.” Am J Kidney Dis 77, no. 6 (June 2021): 898-906.e1. https://doi.org/10.1053/j.ajkd.2020.09.016.
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  - Scales, Charles D., H Henry Lai, Alana C. Desai, Jodi A. Antonelli, Naim M. Maalouf, Gregory E. Tasian, Peter P. Reese, et al. “Study to Enhance Understanding of Stent-Associated Symptoms: Rationale and Study Design.” J Endourol 35, no. 6 (June 2021): 761–68. https://doi.org/10.1089/end.2020.0776.
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  - Rettmann, Maryam E., David R. Holmes, Kristi H. Monahan, Jerome F. Breen, Tristram D. Bahnson, Daniel B. Mark, Jeanne E. Poole, et al. “Treatment-Related Changes in Left Atrial Structure in Atrial Fibrillation: Findings From the CABANA Imaging Substudy.” Circ Arrhythm Electrophysiol 14, no. 5 (May 2021): e008540. https://doi.org/10.1161/CIRCEP.120.008540.
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  - Packer, Douglas L., Jonathan P. Piccini, Kristi H. Monahan, Hussein R. Al-Khalidi, Adam P. Silverstein, Peter A. Noseworthy, Jeanne E. Poole, et al. “Ablation Versus Drug Therapy for Atrial Fibrillation in Heart Failure: Results From the CABANA Trial.” Circulation 143, no. 14 (April 6, 2021): 1377–90. https://doi.org/10.1161/CIRCULATIONAHA.120.050991.
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  - Russo, Andrea M., Emily P. Zeitler, Anna Giczewska, Adam P. Silverstein, Hussein R. Al-Khalidi, Yong-Mei Cha, Kristi H. Monahan, et al. “Association Between Sex and Treatment Outcomes of Atrial Fibrillation Ablation Versus Drug Therapy: Results From the CABANA Trial.” Circulation 143, no. 7 (February 16, 2021): 661–72. https://doi.org/10.1161/CIRCULATIONAHA.120.051558.
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  - Farsky, Pedro S., Jennifer White, Hussein R. Al-Khalidi, Carla A. Sueta, Jean L. Rouleau, Julio A. Panza, Eric J. Velazquez, Christopher M. O’Connor, and Christopher M. Working Group and Surgical Treatment for IsChemic Heart failure Trial Investigators. “Optimal medical therapy with or without surgical revascularization and long-term outcomes in ischemic cardiomyopathy.” J Thorac Cardiovasc Surg, January 7, 2021. https://doi.org/10.1016/j.jtcvs.2020.12.094.
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  - Bedair, K. F., Y. Hong, and H. R. Al-Khalidi. “Copula-frailty models for recurrent event data based on Monte Carlo EM algorithm.” Journal of Statistical Computation and Simulation 91, no. 17 (January 1, 2021): 3530–48. https://doi.org/10.1080/00949655.2021.1942471.
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  - Piccini, Jonathan P., Derick M. Todd, Tyler Massaro, Aimee Lougee, Karl Georg Haeusler, Benjamin Blank, Joseph Paul de Bono, et al. “Changes in quality of life, cognition and functional status following catheter ablation of atrial fibrillation.” Heart 106, no. 24 (December 2020): 1919–26. https://doi.org/10.1136/heartjnl-2020-316612.
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  - Al-Khatib, Sana M., Sean D. Pokorney, Hussein R. Al-Khalidi, Kevin Haynes, Crystal Garcia, David Martin, Jennifer C. Goldsack, et al. “Underuse of oral anticoagulants in privately insured patients with atrial fibrillation: A population being targeted by the IMplementation of a randomized controlled trial to imProve treatment with oral AntiCoagulanTs in patients with Atrial Fibrillation (IMPACT-AFib).” Am Heart J 229 (November 2020): 110–17. https://doi.org/10.1016/j.ahj.2020.07.012.
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  - Kochar, Ajar, Hillary Mulder, Frank W. Rockhold, Iris Baumgartner, Jeffrey S. Berger, Juuso I. Blomster, F Gerry R. Fowkes, et al. “Cause of Death Among Patients With Peripheral Artery Disease: Insights From the EUCLID Trial.” Circ Cardiovasc Qual Outcomes 13, no. 11 (November 2020): e006550. https://doi.org/10.1161/CIRCOUTCOMES.120.006550.
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  - Zink, Matthias Daniel, Winnie Chua, Stef Zeemering, Luigi di Biase, Bayes de Luna Antoni, Callans David, Gerhard Hindricks, et al. “Predictors of recurrence of atrial fibrillation within the first 3 months after ablation.” Europace 22, no. 9 (September 1, 2020): 1337–44. https://doi.org/10.1093/europace/euaa132.
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  - Garcia, Crystal J., Kevin Haynes, Sean D. Pokorney, Nancy D. Lin, Cheryl McMahill-Walraven, Vinit Nair, Lauren Parlett, et al. “Practical challenges in the conduct of pragmatic trials embedded in health plans: Lessons of IMPACT-AFib, an FDA-Catalyst trial.” Clin Trials 17, no. 4 (August 2020): 360–67. https://doi.org/10.1177/1740774520928426.
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  - Kloosterman, Mariëlle, Winnie Chua, Larissa Fabritz, Hussein R. Al-Khalidi, Ulrich Schotten, Jens C. Nielsen, Jonathan P. Piccini, et al. “Sex differences in catheter ablation of atrial fibrillation: results from AXAFA-AFNET 5.” Europace 22, no. 7 (July 1, 2020): 1026–35. https://doi.org/10.1093/europace/euaa015.
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  - Zeitouni, Michel, Hussein R. Al-Khalidi, Mayme L. Roettig, Michele M. Bolles, Shannon M. Doerfler, Christopher B. Fordyce, Anne S. Hellkamp, et al. “Catheterization Laboratory Activation Time in Patients Transferred With ST-Segment-Elevation Myocardial Infarction: Insights From the Mission: Lifeline STEMI Accelerator-2 Project.” Circ Cardiovasc Qual Outcomes 13, no. 7 (July 2020): e006204. https://doi.org/10.1161/CIRCOUTCOMES.119.006204.
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  - Poole, Jeanne E., Tristram D. Bahnson, Kristi H. Monahan, George Johnson, Hoss Rostami, Adam P. Silverstein, Hussein R. Al-Khalidi, et al. “Recurrence of Atrial Fibrillation After Catheter Ablation or Antiarrhythmic Drug Therapy in the CABANA Trial.” J Am Coll Cardiol 75, no. 25 (June 30, 2020): 3105–18. https://doi.org/10.1016/j.jacc.2020.04.065.
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  - Daubert, Melissa A., Jennifer A. White, Hussein R. Al-Khalidi, Eric J. Velazquez, Sunil V. Rao, Anna Lisa Crowley, Uwe Zeymer, et al. “Cardiac remodeling after large ST-elevation myocardial infarction in the current therapeutic era.” Am Heart J 223 (May 2020): 87–97. https://doi.org/10.1016/j.ahj.2020.02.017.
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  - DeVore, Adam D., Bradi B. Granger, Gregg C. Fonarow, Hussein R. Al-Khalidi, Nancy M. Albert, Eldrin F. Lewis, Javed Butler, et al. “Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure: Rationale and design of CONNECT-HF.” Am Heart J 220 (February 2020): 41–50. https://doi.org/10.1016/j.ahj.2019.09.012.
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  - Rymer, Jennifer A., Aditya Mandawat, J Dawn Abbott, Mauricio G. Cohen, Justin E. Davies, Ian C. Gilchrist, Sanjit S. Jolly, et al. “Opportunities for enhancing the care of older patients with ST-elevation myocardial infarction presenting for primary percutaneous coronary intervention: Rationale and design of the SAFE-STEMI for Seniors trial.” Am Heart J 218 (December 2019): 84–91. https://doi.org/10.1016/j.ahj.2019.09.014.
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  - Howlett, Jonathan G., Amanda Stebbins, Mark C. Petrie, Pardeep S. Jhund, Serenella Castelvecchio, Alexander Cherniavsky, Carla A. Sueta, et al. “CABG Improves Outcomes in Patients With Ischemic Cardiomyopathy: 10-Year Follow-Up of the STICH Trial.” Jacc Heart Fail 7, no. 10 (October 2019): 878–87. https://doi.org/10.1016/j.jchf.2019.04.018.
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  - Nicolau, Jose C., Susanna R. Stevens, Hussein R. Al-Khalidi, Fabio B. Jatene, Remo H. M. Furtado, Luis A. O. Dallan, Luiz A. F. Lisboa, et al. “Does prior coronary angioplasty affect outcomes of surgical coronary revascularization? Insights from the STICH trial.” Int J Cardiol 291 (September 15, 2019): 36–41. https://doi.org/10.1016/j.ijcard.2019.03.029.
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  - Panza, Julio A., Alicia M. Ellis, Hussein R. Al-Khalidi, Thomas A. Holly, Daniel S. Berman, Jae K. Oh, Gerald M. Pohost, et al. “Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy.” N Engl J Med 381, no. 8 (August 22, 2019): 739–48. https://doi.org/10.1056/NEJMoa1807365.
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  - Packer, Douglas L., Daniel B. Mark, Richard A. Robb, Kristi H. Monahan, Tristram D. Bahnson, Jeanne E. Poole, Peter A. Noseworthy, et al. “Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial.” Jama 321, no. 13 (April 2, 2019): 1261–74. https://doi.org/10.1001/jama.2019.0693.
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  - Sharma, Abhinav, Adrian Coles, Nishant K. Sekaran, Neha J. Pagidipati, Michael T. Lu, Daniel B. Mark, Kerry L. Lee, Hussein R. Al-Khalidi, Udo Hoffmann, and Pamela S. Douglas. “Stress Testing Versus CT Angiography in Patients With Diabetes and Suspected Coronary Artery Disease.” J Am Coll Cardiol 73, no. 8 (March 5, 2019): 893–902. https://doi.org/10.1016/j.jacc.2018.11.056.
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  - Ambrosy, Andrew P., Susanna R. Stevens, Hussein R. Al-Khalidi, Jean L. Rouleau, Nadia Bouabdallaoui, Peter E. Carson, Christopher Adlbrecht, et al. “Burden of medical co-morbidities and benefit from surgical revascularization in patients with ischaemic cardiomyopathy.” Eur J Heart Fail 21, no. 3 (March 2019): 373–81. https://doi.org/10.1002/ejhf.1404.
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  - Cocoros, Noelle M., Sean D. Pokorney, Kevin Haynes, Crystal Garcia, Hussein R. Al-Khalidi, Sana M. Al-Khatib, Patrick Archdeacon, et al. “FDA-Catalyst-Using FDA's Sentinel Initiative for large-scale pragmatic randomized trials: Approach and lessons learned during the planning phase of the first trial.” Clin Trials 16, no. 1 (February 2019): 90–97. https://doi.org/10.1177/1740774518812776.
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  - Kochar, Ajar, Hussein R. Al-Khalidi, Shannon Doerfler, and Christopher B. Granger. “Reply: Delays From First Medical Contact to Revascularization in Patients With ST-Segment Elevation Myocardial Infarction Presenting With Cardiogenic Shock.” Jacc Cardiovasc Interv 12, no. 1 (January 14, 2019): 107. https://doi.org/10.1016/j.jcin.2018.11.024.
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  - Bouabdallaoui, Nadia, Susanna R. Stevens, Torsten Doenst, Mark C. Petrie, Nawwar Al-Attar, Imtiaz S. Ali, Andrew P. Ambrosy, et al. “Society of Thoracic Surgeons Risk Score and EuroSCORE-2 Appropriately Assess 30-Day Postoperative Mortality in the STICH Trial and a Contemporary Cohort of Patients With Left Ventricular Dysfunction Undergoing Surgical Revascularization.” Circ Heart Fail 11, no. 11 (November 2018): e005531. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005531.
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  - Kochar, Ajar, Hussein R. Al-Khalidi, Steen M. Hansen, Jay S. Shavadia, Mayme L. Roettig, Christopher B. Fordyce, Shannon Doerfler, et al. “Delays in Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction Patients Presenting With Cardiogenic Shock.” Jacc Cardiovasc Interv 11, no. 18 (September 24, 2018): 1824–33. https://doi.org/10.1016/j.jcin.2018.06.030.
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  - Kirchhof, Paulus, Karl Georg Haeusler, Benjamin Blank, Joseph De Bono, David Callans, Arif Elvan, Thomas Fetsch, et al. “Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation.” Eur Heart J 39, no. 32 (August 21, 2018): 2942–55. https://doi.org/10.1093/eurheartj/ehy176.
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  - Pellikka, Patricia A., Lilin She, Thomas A. Holly, Grace Lin, Padmini Varadarajan, Ramdas G. Pai, Robert O. Bonow, et al. “Variability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction.” Jama Netw Open 1, no. 4 (August 3, 2018): e181456. https://doi.org/10.1001/jamanetworkopen.2018.1456.
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  - Saito, Shigeru, Mitchell W. Krucoff, Shigeru Nakamura, Roxana Mehran, Akiko Maehara, Hussein R. Al-Khalidi, Stephen M. Rowland, et al. “Japan-United States of America Harmonized Assessment by Randomized Multicentre Study of OrbusNEich's Combo StEnt (Japan-USA HARMONEE) study: primary results of the pivotal registration study of combined endothelial progenitor cell capture and drug-eluting stent in patients with ischaemic coronary disease and non-ST-elevation acute coronary syndrome.” Eur Heart J 39, no. 26 (July 7, 2018): 2460–68. https://doi.org/10.1093/eurheartj/ehy275.
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  - Bouabdallaoui, Nadia, Susanna R. Stevens, Torsten Doenst, Krzysztof Wrobel, Denis Bouchard, Marek A. Deja, Robert E. Michler, et al. “Impact of Intubation Time on Survival following Coronary Artery Bypass Grafting: Insights from the Surgical Treatment for Ischemic Heart Failure (STICH) Trial.” J Cardiothorac Vasc Anesth 32, no. 3 (June 2018): 1256–63. https://doi.org/10.1053/j.jvca.2017.12.038.
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  - Packer, Douglas L., Daniel B. Mark, Richard A. Robb, Kristi H. Monahan, Tristram D. Bahnson, Kathleen Moretz, Jeanne E. Poole, et al. “Catheter Ablation versus Antiarrhythmic Drug Therapy for Atrial Fibrillation (CABANA) Trial: Study Rationale and Design.” Am Heart J 199 (May 2018): 192–99. https://doi.org/10.1016/j.ahj.2018.02.015.
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  - Piccini, Jonathan P., Stuart J. Connolly, William T. Abraham, Jeff S. Healey, Benjamin A. Steinberg, Hussein R. Al-Khalidi, Patricia Dignacco, et al. “A genotype-directed comparative effectiveness trial of Bucindolol and metoprolol succinate for prevention of symptomatic atrial fibrillation/atrial flutter in patients with heart failure: Rationale and design of the GENETIC-AF trial.” Am Heart J 199 (May 2018): 51–58. https://doi.org/10.1016/j.ahj.2017.12.001.
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  - Jollis, James G., Hussein R. Al-Khalidi, Mayme L. Roettig, Peter B. Berger, Claire C. Corbett, Shannon M. Doerfler, Christopher B. Fordyce, et al. “Impact of Regionalization of ST-Segment-Elevation Myocardial Infarction Care on Treatment Times and Outcomes for Emergency Medical Services-Transported Patients Presenting to Hospitals With Percutaneous Coronary Intervention: Mission: Lifeline Accelerator-2.” Circulation 137, no. 4 (January 23, 2018): 376–87. https://doi.org/10.1161/CIRCULATIONAHA.117.032446.
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  - Prior, David L., Susanna R. Stevens, Hussain R. Al-Khalidi, Thomas A. Holly, Daniel S. Berman, and Daniel S. STICH Investigators. “The authors' reply to the letter from Kerkhof et al entitled 'The importance of (measuring) the end-systolic volume index in predicting survival'.” Heart 104, no. 2 (January 2018): 1. https://doi.org/10.1136/heartjnl-2017-312346.
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  - Stewart, Ralph A. H., Dominika Szalewska, Amanda Stebbins, Hussein R. Al-Khalidi, John G. H. Cleland, Andrzej Rynkiewicz, Mark H. Drazner, et al. “Six-minute walk distance after coronary artery bypass grafting compared with medical therapy in ischaemic cardiomyopathy.” Open Heart 5, no. 1 (2018): e000752. https://doi.org/10.1136/openhrt-2017-000752.
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  - Trattner, Sigal, Sandra Halliburton, Carla M. Thompson, Yanping Xu, Anjali Chelliah, Sachin R. Jambawalikar, Boyu Peng, et al. “Cardiac-Specific Conversion Factors to Estimate Radiation Effective Dose From Dose-Length Product in Computed Tomography.” Jacc Cardiovasc Imaging 11, no. 1 (January 2018): 64–74. https://doi.org/10.1016/j.jcmg.2017.06.006.
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  - Sharma, Abhinav, Nishant K. Sekaran, Adrian Coles, Neha J. Pagidipati, Udo Hoffmann, Daniel B. Mark, Kerry L. Lee, et al. “Impact of Diabetes Mellitus on the Evaluation of Stable Chest Pain Patients: Insights From the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) Trial.” J Am Heart Assoc 6, no. 11 (October 31, 2017). https://doi.org/10.1161/JAHA.117.007019.
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  - Hinohara, Tomoya T., Hussein R. Al-Khalidi, Christopher B. Fordyce, Xiangqiong Gu, Matthew W. Sherwood, Mayme L. Roettig, Claire C. Corbett, et al. “Impact of Regional Systems of Care on Disparities in Care Among Female and Black Patients Presenting With ST-Segment-Elevation Myocardial Infarction.” J Am Heart Assoc 6, no. 10 (October 24, 2017). https://doi.org/10.1161/JAHA.117.007122.
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  - Vinereanu, Dragos, Renato D. Lopes, M Cecilia Bahit, Denis Xavier, Jie Jiang, Hussein R. Al-Khalidi, Wensheng He, et al. “A multifaceted intervention to improve treatment with oral anticoagulants in atrial fibrillation (IMPACT-AF): an international, cluster-randomised trial.” Lancet 390, no. 10104 (October 14, 2017): 1737–46. https://doi.org/10.1016/S0140-6736(17)32165-7.
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  - Kragholm, Kristian, Di Lu, Karen Chiswell, Hussein R. Al-Khalidi, Mayme L. Roettig, Matthew Roe, James Jollis, and Christopher B. Granger. “Improvement in Care and Outcomes for Emergency Medical Service-Transported Patients With ST-Elevation Myocardial Infarction (STEMI) With and Without Prehospital Cardiac Arrest: A Mission: Lifeline STEMI Accelerator Study.” J Am Heart Assoc 6, no. 10 (October 11, 2017). https://doi.org/10.1161/JAHA.117.005717.
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  - Vinereanu, Dragos, Hussein R. Al-Khalidi, Meena P. Rao, Wensheng He, Renato D. Lopes, Cecilia M. Bahit, Andrea O. Ciobanu, et al. “Regional differences in presentation and antithrombotic treatment of patients with atrial fibrillation: Baseline characteristics from a clustered randomized trial to IMProve treatment with AntiCoagulanTs in patients with atrial fibrillation (IMPACT-AF).” Am Heart J 192 (October 2017): 38–47. https://doi.org/10.1016/j.ahj.2017.07.004.
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  - Lu, Michael T., Pamela S. Douglas, James E. Udelson, Elizabeth Adami, Brian B. Ghoshhajra, Michael H. Picard, Rhonda Roberts, et al. “Safety of coronary CT angiography and functional testing for stable chest pain in the PROMISE trial: A randomized comparison of test complications, incidental findings, and radiation dose.” J Cardiovasc Comput Tomogr 11, no. 5 (September 2017): 373–82. https://doi.org/10.1016/j.jcct.2017.08.005.
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  - Prior, David L., Susanna R. Stevens, Thomas A. Holly, Michal Krejca, Alexandros Paraforos, Gerald M. Pohost, Krysti Byrd, et al. “Regional left ventricular function does not predict survival in ischaemic cardiomyopathy after cardiac surgery.” Heart 103, no. 17 (September 2017): 1359–67. https://doi.org/10.1136/heartjnl-2016-310693.
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  - Hess, Paul L., Hussein R. Al-Khalidi, Daniel J. Friedman, Hillary Mulder, Anna Kucharska-Newton, Wayne R. Rosamond, Renato D. Lopes, et al. “The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study.” J Am Heart Assoc 6, no. 8 (August 23, 2017). https://doi.org/10.1161/JAHA.117.006103.
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  - Miszalski-Jamka, Karol, John L. Jefferies, Wojciech Mazur, Jan Głowacki, Jianhong Hu, Monika Lazar, Richard A. Gibbs, et al. “Novel Genetic Triggers and Genotype-Phenotype Correlations in Patients With Left Ventricular Noncompaction.” Circ Cardiovasc Genet 10, no. 4 (August 2017). https://doi.org/10.1161/CIRCGENETICS.117.001763.
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  - Kong, David F., Shigeru Saito, Shigeru Nakamura, Roxana Mehran, Stephen M. Rowland, Allison Handler, Hussein R. Al-Khalidi, and Mitchell W. Krucoff. “Rationale and design of the Japan-USA harmonized assessment by randomized, multicenter study of OrbusNEich's combo StEnt (Japan-USA HARMONEE): Assessment of a novel DES platform for percutaneous coronary revascularization in patients with ischemic coronary disease and non-ST-elevation acute coronary syndrome.” Am Heart J 187 (May 2017): 112–21. https://doi.org/10.1016/j.ahj.2017.02.004.
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  - Pai, Ramdas G., Padmini Varadarajan, Jean L. Rouleau, Amanda L. Stebbins, Eric J. Velazquez, Hussein R. Al-Khalidi, and Gerald M. Pohost. “Value of Cardiovascular Magnetic Resonance Imaging-Derived Baseline Left Ventricular Ejection Fraction and Volumes for Precise Risk Stratification of Patients With Ischemic Cardiomyopathy: Insights From the Surgical Treatment for Ischemic Heart Failure (STICH) Trial.” Jama Cardiol 2, no. 5 (May 1, 2017): 577–79. https://doi.org/10.1001/jamacardio.2016.5492.
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  - Fordyce, Christopher B., Pamela S. Douglas, Rhonda S. Roberts, Udo Hoffmann, Hussein R. Al-Khalidi, Manesh R. Patel, Christopher B. Granger, et al. “Identification of Patients With Stable Chest Pain Deriving Minimal Value From Noninvasive Testing: The PROMISE Minimal-Risk Tool, A Secondary Analysis of a Randomized Clinical Trial.” Jama Cardiol 2, no. 4 (April 1, 2017): 400–408. https://doi.org/10.1001/jamacardio.2016.5501.
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  - Di Biase, Luigi, David Callans, Karl Georg Hæusler, Gerhard Hindricks, Hussein Al-Khalidi, Lluis Mont, Jens Cosedis Nielsen, Jonathan P. Piccini, Ulrich Schotten, and Paulus Kirchhof. “Rationale and design of AXAFA-AFNET 5: an investigator-initiated, randomized, open, blinded outcome assessment, multi-centre trial to comparing continuous apixaban to vitamin K antagonists in patients undergoing atrial fibrillation catheter ablation.” Europace 19, no. 1 (January 2017): 132–38. https://doi.org/10.1093/europace/euw368.
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  - Fordyce, Christopher B., Hussein R. Al-Khalidi, James G. Jollis, Mayme L. Roettig, Joan Gu, Akshay Bagai, Peter B. Berger, et al. “Association of Rapid Care Process Implementation on Reperfusion Times Across Multiple ST-Segment-Elevation Myocardial Infarction Networks.” Circ Cardiovasc Interv 10, no. 1 (January 2017). https://doi.org/10.1161/CIRCINTERVENTIONS.116.004061.
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  - Bedair, K., Y. Hong, J. Li, and H. R. Al-Khalidi. “Multivariate frailty models for multi-type recurrent event data and its application to cancer prevention trial.” Computational Statistics and Data Analysis 101 (September 1, 2016): 161–73. https://doi.org/10.1016/j.csda.2016.01.018.
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  - Rao, Sunil V., Uwe Zeymer, Pamela S. Douglas, Hussein Al-Khalidi, Jennifer A. White, Jingyu Liu, Howard Levy, et al. “Bioabsorbable Intracoronary Matrix for Prevention of Ventricular Remodeling After Myocardial Infarction.” J Am Coll Cardiol 68, no. 7 (August 16, 2016): 715–23. https://doi.org/10.1016/j.jacc.2016.05.053.
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  - Povsic, Thomas J., Timothy D. Henry, Jay H. Traverse, F David Fortuin, Gary L. Schaer, Dean J. Kereiakes, Richard A. Schatz, et al. “The RENEW Trial: Efficacy and Safety of Intramyocardial Autologous CD34(+) Cell Administration in Patients With Refractory Angina.” Jacc Cardiovasc Interv 9, no. 15 (August 8, 2016): 1576–85. https://doi.org/10.1016/j.jcin.2016.05.003.
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  - Jollis, James G., Hussein R. Al-Khalidi, Mayme L. Roettig, Peter B. Berger, Claire C. Corbett, Harold L. Dauerman, Christopher B. Fordyce, et al. “Regional Systems of Care Demonstration Project: American Heart Association Mission: Lifeline STEMI Systems Accelerator.” Circulation 134, no. 5 (August 2, 2016): 365–74. https://doi.org/10.1161/CIRCULATIONAHA.115.019474.
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  - Mehmood, Muddassir, Stephanie A. Ambach, Michael D. Taylor, John L. Jefferies, Subha V. Raman, Robin J. Taylor, Hemant Sawani, et al. “Relationship of Right Ventricular Size and Function with Respiratory Status in Duchenne Muscular Dystrophy.” Pediatr Cardiol 37, no. 5 (June 2016): 878–83. https://doi.org/10.1007/s00246-016-1362-2.
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  - Mehmood, Muddassir, Stephanie A. Ambach, Michael D. Taylor, John L. Jefferies, Subha V. Raman, Robin J. Taylor, Hemant Sawnani, et al. “Erratum to: Relationship of Right Ventricular Size and Function with Respiratory Status in Duchenne Muscular Dystrophy.” Pediatr Cardiol 37, no. 5 (June 2016): 989. https://doi.org/10.1007/s00246-016-1388-5.
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  - Rao, Meena P., Andrea O. Ciobanu, Renato D. Lopes, Kathleen A. Fox, Ying Xian, Sean D. Pokorney, Hussein R. Al-Khalidi, et al. “A clustered randomized trial to IMProve treatment with AntiCoagulanTs in patients with Atrial Fibrillation (IMPACT-AF): design and rationale.” Am Heart J 176 (June 2016): 107–13. https://doi.org/10.1016/j.ahj.2016.03.011.
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  - Velazquez, Eric J., Kerry L. Lee, Robert H. Jones, Hussein R. Al-Khalidi, James A. Hill, Julio A. Panza, Robert E. Michler, et al. “Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy.” N Engl J Med 374, no. 16 (April 21, 2016): 1511–20. https://doi.org/10.1056/NEJMoa1602001.
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  - Garber, Adam M., Robert J. Mentz, Hussein R. Al-Khalidi, Linda K. Shaw, Mona Fiuzat, Christopher M. O’Connor, and Eric J. Velazquez. “Clinical predictors and outcomes of patients with left ventricular thrombus following ST-segment elevation myocardial infarction.” J Thromb Thrombolysis 41, no. 3 (April 2016): 365–73. https://doi.org/10.1007/s11239-015-1252-0.
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  - Jolicœur, E Marc, Allison Dunning, Serenella Castelvecchio, Rafal Dabrowski, Myron A. Waclawiw, Mark C. Petrie, Ralph Stewart, et al. “Importance of angina in patients with coronary disease, heart failure, and left ventricular systolic dysfunction: insights from STICH.” J Am Coll Cardiol 66, no. 19 (November 10, 2015): 2092–2100. https://doi.org/10.1016/j.jacc.2015.08.882.
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  - Rao, Sunil V., Uwe Zeymer, Pamela S. Douglas, Hussein Al-Khalidi, Jingyu Liu, C Michael Gibson, Robert W. Harrison, Diane S. Joseph, Reinilde Heyrman, and Mitchell W. Krucoff. “A randomized, double-blind, placebo-controlled trial to evaluate the safety and effectiveness of intracoronary application of a novel bioabsorbable cardiac matrix for the prevention of ventricular remodeling after large ST-segment elevation myocardial infarction: Rationale and design of the PRESERVATION I trial.” Am Heart J 170, no. 5 (November 2015): 929–37. https://doi.org/10.1016/j.ahj.2015.08.017.
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  - Velazquez, Eric J., Zainab Samad, Hussein R. Al-Khalidi, Chithra Sangli, Paul A. Grayburn, Joseph M. Massaro, Susanna R. Stevens, Ted E. Feldman, and Mitchell W. Krucoff. “The MitraClip and survival in patients with mitral regurgitation at high risk for surgery: A propensity-matched comparison.” Am Heart J 170, no. 5 (November 2015): 1050-1059.e3. https://doi.org/10.1016/j.ahj.2015.08.004.
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  - Samad, Zainab, Linda K. Shaw, Matthew Phelan, Mads Ersboll, Niels Risum, Hussein R. Al-Khalidi, Donald D. Glower, et al. “Management and outcomes in patients with moderate or severe functional mitral regurgitation and severe left ventricular dysfunction.” Eur Heart J 36, no. 40 (October 21, 2015): 2733–41. https://doi.org/10.1093/eurheartj/ehv343.
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  - Mehmood, Muddassir, Kan N. Hor, Hussein R. Al-Khalidi, D Woodrow Benson, John L. Jefferies, Michael D. Taylor, Gregory F. Egnaczyk, et al. “Comparison of right and left ventricular function and size in Duchenne muscular dystrophy.” Eur J Radiol 84, no. 10 (October 2015): 1938–42. https://doi.org/10.1016/j.ejrad.2015.07.007.
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  - Wrobel, Krzysztof, Susanna R. Stevens, Robert H. Jones, Craig H. Selzman, Andre Lamy, Thomas M. Beaver, Ljubomir T. Djokovic, et al. “Influence of Baseline Characteristics, Operative Conduct, and Postoperative Course on 30-Day Outcomes of Coronary Artery Bypass Grafting Among Patients With Left Ventricular Dysfunction: Results From the Surgical Treatment for Ischemic Heart Failure (STICH) Trial.” Circulation 132, no. 8 (August 25, 2015): 720–30. https://doi.org/10.1161/CIRCULATIONAHA.114.014932.
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  - Held, Claes, Elaine M. Hylek, John H. Alexander, Michael Hanna, Renato D. Lopes, Daniel M. Wojdyla, Laine Thomas, et al. “Clinical outcomes and management associated with major bleeding in patients with atrial fibrillation treated with apixaban or warfarin: insights from the ARISTOTLE trial.” Eur Heart J 36, no. 20 (May 21, 2015): 1264–72. https://doi.org/10.1093/eurheartj/ehu463.
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  - Pun, Patrick H., Anne S. Hellkamp, Gillian D. Sanders, John P. Middleton, Stephen C. Hammill, Hussein R. Al-Khalidi, Lesley H. Curtis, Gregg C. Fonarow, and Sana M. Al-Khatib. “Primary prevention implantable cardioverter defibrillators in end-stage kidney disease patients on dialysis: a matched cohort study.” Nephrol Dial Transplant 30, no. 5 (May 2015): 829–35. https://doi.org/10.1093/ndt/gfu274.
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  - Póvoa, Pedro, Jorge I. F. Salluh, Maria L. Martinez, Raquel Guillamat-Prats, Dianne Gallup, Hussein R. Al-Khalidi, B Taylor Thompson, V Marco Ranieri, and Antonio Artigas. “Clinical impact of stress dose steroids in patients with septic shock: insights from the PROWESS-Shock trial.” Crit Care 19 (April 28, 2015): 193. https://doi.org/10.1186/s13054-015-0921-x.
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  - Douglas, Pamela S., Udo Hoffmann, Manesh R. Patel, Daniel B. Mark, Hussein R. Al-Khalidi, Brendan Cavanaugh, Jason Cole, et al. “Outcomes of anatomical versus functional testing for coronary artery disease.” N Engl J Med 372, no. 14 (April 2, 2015): 1291–1300. https://doi.org/10.1056/NEJMoa1415516.
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  - Zeitler, Emily P., Anne S. Hellkamp, Gregg C. Fonarow, Stephen C. Hammill, Lesley H. Curtis, Adrian F. Hernandez, Hussein R. Al-Khalidi, et al. “Primary prevention implantable cardioverter-defibrillators and survival in older women.” Jacc Heart Fail 3, no. 2 (February 2015): 159–67. https://doi.org/10.1016/j.jchf.2014.09.006.
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  - Pokorney, Sean D., Anne S. Hellkamp, Clyde W. Yancy, Lesley H. Curtis, Stephen C. Hammill, Eric D. Peterson, Frederick A. Masoudi, et al. “Primary prevention implantable cardioverter-defibrillators in older racial and ethnic minority patients.” Circ Arrhythm Electrophysiol 8, no. 1 (February 2015): 145–51. https://doi.org/10.1161/CIRCEP.114.001878.
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  - Miszalski-Jamka, Tomasz, Wojciech Szczeklik, Barbara Sokołowska, Krzysztof Karwat, Karol Miszalski-Jamka, Przemysław Jaźwiec, Łukasz A. Małek, et al. “Noncorticosteroid immunosuppression limits myocardial damage and contractile dysfunction in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome).” J Am Coll Cardiol 65, no. 1 (January 6, 2015): 103–5. https://doi.org/10.1016/j.jacc.2014.08.055.
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  - Hor, Kan N., Narayan Kissoon, Wojciech Mazur, Resmi Gupta, Richard F. Ittenbach, Hussein R. Al-Khalidi, Linda H. Cripe, et al. “Regional circumferential strain is a biomarker for disease severity in duchenne muscular dystrophy heart disease: a cross-sectional study.” Pediatr Cardiol 36, no. 1 (January 2015): 111–19. https://doi.org/10.1007/s00246-014-0972-9.
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  - Póvoa, P., J. I. Salluh, M. L. Martinez, R. Guillamat-Prats, D. Gallup, H. R. Al-Khalidi, B. T. Thompson, V. M. Ranieri, and A. Artigas. “Clinical impact of stress dose steroids in patients with septic shock: Insights from the PROWESS-Shock trial.” Critical Care, 2015. https://doi.org/10.1186/s13054-015-0921-x.
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  - Hess, Paul L., Anne S. Hellkamp, Eric D. Peterson, Gillian D. Sanders, Hussein R. Al-Khalidi, Lesley H. Curtis, Bradley G. Hammill, et al. “Survival after primary prevention implantable cardioverter-defibrillator placement among patients with chronic kidney disease.” Circ Arrhythm Electrophysiol 7, no. 5 (October 2014): 793–99. https://doi.org/10.1161/CIRCEP.114.001455.
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  - Newby, L Kristin, Michael S. Marber, Chiara Melloni, Lea Sarov-Blat, Laura H. Aberle, Philip E. Aylward, Gengqian Cai, et al. “Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.” Lancet 384, no. 9949 (September 27, 2014): 1187–95. https://doi.org/10.1016/S0140-6736(14)60417-7.
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  - Al-Khatib, Sana M., Anne S. Hellkamp, Gregg C. Fonarow, Daniel B. Mark, Lesley H. Curtis, Adrian F. Hernandez, Kevin J. Anstrom, et al. “Association between prophylactic implantable cardioverter-defibrillators and survival in patients with left ventricular ejection fraction between 30% and 35%.” Jama 311, no. 21 (June 4, 2014): 2209–15. https://doi.org/10.1001/jama.2014.5310.
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  - Douglas, Pamela S., Udo Hoffmann, Kerry L. Lee, Daniel B. Mark, Hussein R. Al-Khalidi, Kevin Anstrom, Rowena J. Dolor, et al. “PROspective Multicenter Imaging Study for Evaluation of chest pain: rationale and design of the PROMISE trial.” Am Heart J 167, no. 6 (June 2014): 796-803.e1. https://doi.org/10.1016/j.ahj.2014.03.003.
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  - Bagai, Akshay, Hussein R. Al-Khalidi, Matthew W. Sherwood, Daniel Muñoz, Mayme L. Roettig, James G. Jollis, and Christopher B. Granger. “Regional systems of care demonstration project: Mission: Lifeline STEMI Systems Accelerator: design and methodology.” Am Heart J 167, no. 1 (January 2014): 15-21.e3. https://doi.org/10.1016/j.ahj.2013.10.005.
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  - Hor, Kan N., Michael D. Taylor, Hussein R. Al-Khalidi, Linda H. Cripe, Subha V. Raman, John L. Jefferies, Robert O’Donnell, D Woodrow Benson, and Wojciech Mazur. “Prevalence and distribution of late gadolinium enhancement in a large population of patients with Duchenne muscular dystrophy: effect of age and left ventricular systolic function.” J Cardiovasc Magn Reson 15 (December 21, 2013): 107. https://doi.org/10.1186/1532-429X-15-107.
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  - Michler, Robert E., Jean L. Rouleau, Hussein R. Al-Khalidi, Robert O. Bonow, Patricia A. Pellikka, Gerald M. Pohost, Thomas A. Holly, et al. “Insights from the STICH trial: change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction.” J Thorac Cardiovasc Surg 146, no. 5 (November 2013): 1139-1145.e6. https://doi.org/10.1016/j.jtcvs.2012.09.007.
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  - Bagai, Akshay, Hussein R. Al-Khalidi, Daniel Muñoz, Lisa Monk, Mayme L. Roettig, Claire C. Corbett, J Lee Garvey, B Hadley Wilson, Christopher B. Granger, and James G. Jollis. “Bypassing the emergency department and time to reperfusion in patients with prehospital ST-segment-elevation: findings from the reperfusion in acute myocardial infarction in Carolina Emergency Departments project.” Circ Cardiovasc Interv 6, no. 4 (August 2013): 399–406. https://doi.org/10.1161/CIRCINTERVENTIONS.112.000136.
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  - Al-Khatib, Sana M., Anne Hellkamp, Gust H. Bardy, Stephen Hammill, W Jackson Hall, Daniel B. Mark, Kevin J. Anstrom, et al. “Survival of patients receiving a primary prevention implantable cardioverter-defibrillator in clinical practice vs clinical trials.” Jama 309, no. 1 (January 2, 2013): 55–62. https://doi.org/10.1001/jama.2012.157182.
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  - Muñoz, Daniel, Mayme L. Roettig, Lisa Monk, Hussein Al-Khalidi, James G. Jollis, and Christopher B. Granger. “Transport time and care processes for patients transferred with ST-segment-elevation myocardial infarction: the reperfusion in acute myocardial infarction in Carolina emergency rooms experience.” Circ Cardiovasc Interv 5, no. 4 (August 1, 2012): 555–62. https://doi.org/10.1161/CIRCINTERVENTIONS.112.968461.
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  - Jollis, James G., Hussein R. Al-Khalidi, Lisa Monk, Mayme L. Roettig, J Lee Garvey, Akinyele O. Aluko, B Hadley Wilson, et al. “Expansion of a regional ST-segment-elevation myocardial infarction system to an entire state.” Circulation 126, no. 2 (July 10, 2012): 189–95. https://doi.org/10.1161/CIRCULATIONAHA.111.068049.
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  - Truffa, Adriano A. M., Christopher B. Granger, Kyle R. White, L Kristin Newby, Rajendra H. Mehta, Judith S. Hochman, Manesh R. Patel, et al. “Serious infection after acute myocardial infarction: incidence, clinical features, and outcomes.” Jacc Cardiovasc Interv 5, no. 7 (July 2012): 769–76. https://doi.org/10.1016/j.jcin.2012.03.018.
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  - Ranieri, V Marco, B Taylor Thompson, Philip S. Barie, Jean-François Dhainaut, Ivor S. Douglas, Simon Finfer, Bengt Gårdlund, et al. “Drotrecogin alfa (activated) in adults with septic shock.” N Engl J Med 366, no. 22 (May 31, 2012): 2055–64. https://doi.org/10.1056/NEJMoa1202290.
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  - Al-Khatib, Sana M., Anne S. Hellkamp, Adrian F. Hernandez, Gregg C. Fonarow, Kevin L. Thomas, Hussein R. Al-Khalidi, Paul A. Heidenreich, et al. “Trends in use of implantable cardioverter-defibrillator therapy among patients hospitalized for heart failure: have the previously observed sex and racial disparities changed over time?” Circulation 125, no. 9 (March 6, 2012): 1094–1101. https://doi.org/10.1161/CIRCULATIONAHA.111.066605.
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  - Mazur, Wojciech, Kan N. Hor, Joshua T. Germann, Robert J. Fleck, Hussein R. Al-Khalidi, Janaka P. Wansapura, Eugene S. Chung, et al. “Patterns of left ventricular remodeling in patients with Duchenne Muscular Dystrophy: a cardiac MRI study of ventricular geometry, global function, and strain.” Int J Cardiovasc Imaging 28, no. 1 (January 2012): 99–107. https://doi.org/10.1007/s10554-010-9781-2.
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  - Al-Khalidi, Hussein R., Yili Hong, Thomas R. Fleming, and Terry M. Therneau. “Insights on the robust variance estimator under recurrent-events model.” Biometrics 67, no. 4 (December 2011): 1564–72. https://doi.org/10.1111/j.1541-0420.2011.01589.x.
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  - Samad, Zainab, Eric Yow, Linda K. Shaw, Hussein R. Al-Khalidi, Kristine Arges, John H. Toptine, Mitchell Krucoff, Andrew Wang, James G. Jollis, and Eric J. Velazquez. “Prevalence and Natural History of Moderate or Severe Mitral Regurgitation: an Observational Study from a Single Center.” Circulation 124, no. 21 (November 22, 2011).
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  - Hor, Kan N., Wojciech Mazur, Michael D. Taylor, Hussein R. Al-Khalidi, Linda H. Cripe, John L. Jefferies, Subha V. Raman, et al. “Effects of steroids and angiotensin converting enzyme inhibition on circumferential strain in boys with Duchenne muscular dystrophy: a cross-sectional and longitudinal study utilizing cardiovascular magnetic resonance.” J Cardiovasc Magn Reson 13 (October 19, 2011): 60. https://doi.org/10.1186/1532-429X-13-60.
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  - Granger, Christopher B., John H. Alexander, John J. V. McMurray, Renato D. Lopes, Elaine M. Hylek, Michael Hanna, Hussein R. Al-Khalidi, et al. “Apixaban versus warfarin in patients with atrial fibrillation.” N Engl J Med 365, no. 11 (September 15, 2011): 981–92. https://doi.org/10.1056/NEJMoa1107039.
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  - Bhatti, Sabha, Abdul Hakeem, Mian Atif Yousuf, Hussein R. Al-Khalidi, Wojciech Mazur, and Yukitaka Shizukuda. “Diagnostic performance of computed tomography angiography for differentiating ischemic vs nonischemic cardiomyopathy.” J Nucl Cardiol 18, no. 3 (May 2011): 407–20. https://doi.org/10.1007/s12350-011-9346-3.
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  - Hor, Kan N., Janaka P. Wansapura, Hussein R. Al-Khalidi, William M. Gottliebson, Michael D. Taylor, Richard J. Czosek, Sherif F. Nagueh, et al. “Presence of mechanical dyssynchrony in Duchenne muscular dystrophy.” J Cardiovasc Magn Reson 13 (February 2, 2011): 12. https://doi.org/10.1186/1532-429X-13-12.
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  - Hor, Kan N., William M. Gottliebson, Christopher Carson, Erin Wash, James Cnota, Robert Fleck, Janaka Wansapura, et al. “Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis.” Jacc Cardiovasc Imaging 3, no. 2 (February 2010): 144–51. https://doi.org/10.1016/j.jcmg.2009.11.006.
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  - Jolicoeur, E Marc, William W. O’Neill, Anne Hellkamp, Christian W. Hamm, David R. Holmes, Hussein R. Al-Khalidi, Manesh R. Patel, et al. “Transfusion and mortality in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention.” Eur Heart J 30, no. 21 (November 2009): 2575–83. https://doi.org/10.1093/eurheartj/ehp279.
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  - Dorian, Paul, Hussein R. Al-Khalidi, Stefan H. Hohnloser, Jose M. Brum, Preston M. Dunnmon, Craig M. Pratt, Michael J. Holroyde, Peter Kowey, and Peter Shock Inhibition Evaluation with Azimilide Investigators. “Azimilide reduces emergency department visits and hospitalizations in patients with an implantable cardioverter-defibrillator in a placebo-controlled clinical trial.” J Am Coll Cardiol 52, no. 13 (September 23, 2008): 1076–83. https://doi.org/10.1016/j.jacc.2008.05.055.
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  - Colon-Emeric, C. S., K. W. Lyles, and P. Mesenbrink. “Zoledronate, fractures, and mortality after hip fracture [4].” New England Journal of Medicine 358, no. 9 (February 28, 2008): 968–69.
  - Karam, R., H. Al-Khalidi, and M. Steinbuch. “Zoledronate, fractures, and mortality after hip fracture [3].” New England Journal of Medicine 358, no. 9 (February 28, 2008): 968.
  - Karam, Roger, Hussein Al-Khalidi, and Michael Steinbuch. “Zoledronate, fractures, and mortality after hip fracture.” N Engl J Med 358, no. 9 (February 28, 2008): 969.
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  - Tjandrawidjaja, Michael C., Yuling Fu, Hussein Al-Khalidi, Thomas G. Todaro, Peter Adams, Frans Van de Werf, Christopher B. Granger, Paul W. Armstrong, and Paul W. APEX-AMI Investigators. “Failure of investigator adherence to electrocardiographic entry criteria is frequent and influences clinical outcomes: lessons from APEX-AMI.” Eur Heart J 28, no. 23 (December 2007): 2850–57. https://doi.org/10.1093/eurheartj/ehm453.
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  - Hohnloser, Stefan H., Hussein R. Al-Khalidi, Craig M. Pratt, Jose M. Brum, Daljit S. Tatla, Patrick Tchou, Paul Dorian, and Paul SHock Inhibition Evaluation with AzimiLiDe (SHIELD) Investigators. “Electrical storm in patients with an implantable defibrillator: incidence, features, and preventive therapy: insights from a randomized trial.” Eur Heart J 27, no. 24 (December 2006): 3027–32. https://doi.org/10.1093/eurheartj/ehl276.
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  - Pratt, Craig M., Hussein R. Al-Khalidi, Jose M. Brum, Michael J. Holroyde, Peter J. Schwartz, Stephen R. Marcello, Martin Borggrefe, Paul Dorian, A John Camm, and A John Azimilide Trials Investigators. “Cumulative experience of azimilide-associated torsades de pointes ventricular tachycardia in the 19 clinical studies comprising the azimilide database.” J Am Coll Cardiol 48, no. 3 (August 1, 2006): 471–77. https://doi.org/10.1016/j.jacc.2006.04.075.
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  - Armstrong, Paul W., Peter X. Adams, Hussein R. Al-Khalidi, Christian Hamm, David Holmes, William O’Neill, Thomas G. Todaro, et al. “Assessment of Pexelizumab in Acute Myocardial Infarction (APEX AMI): a multicenter, randomized, double-blind, parallel-group, placebo-controlled study of pexelizumab in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.” Am Heart J 149, no. 3 (March 2005): 402–7. https://doi.org/10.1016/j.ahj.2004.12.015.
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  - Pratt, Craig M., Paul Dorian, Hussein R. Al-Khalidi, Jose M. Brum, Martin Borggrefe, Daljit S. Tatla, Johannes Brachmann, et al. “Design of the SHock Inhibition Evaluation with Azimilide (SHIELD) study: a novel method to assess antiarrhythmic drug effect in patients with an implantable cardioverter-defibrillator.” Am J Cardiol 95, no. 2 (January 15, 2005): 274–76. https://doi.org/10.1016/j.amjcard.2004.08.096.
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  - Dorian, Paul, Martin Borggrefe, Hussein R. Al-Khalidi, Stefan H. Hohnloser, Jose M. Brum, Daljit S. Tatla, Johannes Brachmann, et al. “Placebo-controlled, randomized clinical trial of azimilide for prevention of ventricular tachyarrhythmias in patients with an implantable cardioverter defibrillator.” Circulation 110, no. 24 (December 14, 2004): 3646–54. https://doi.org/10.1161/01.CIR.0000149240.98971.A8.
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  - Pratt, Craig M., Steven N. Singh, Hussein R. Al-Khalidi, Jose M. Brum, Michael J. Holroyde, Stephen R. Marcello, Peter J. Schwartz, A John Camm, and A John ALIVE Investigators. “The efficacy of azimilide in the treatment of atrial fibrillation in the presence of left ventricular systolic dysfunction: results from the Azimilide Postinfarct Survival Evaluation (ALIVE) trial.” J Am Coll Cardiol 43, no. 7 (April 7, 2004): 1211–16. https://doi.org/10.1016/j.jacc.2003.10.057.
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  - Camm, A John, Craig M. Pratt, Peter J. Schwartz, Hussein R. Al-Khalidi, Maria J. Spyt, Michael J. Holroyde, Roger Karam, Edmund H. Sonnenblick, Jose M. G. Brum, and Jose M. G. AzimiLide post Infarct surVival Evaluation (ALIVE) Investigators. “Mortality in patients after a recent myocardial infarction: a randomized, placebo-controlled trial of azimilide using heart rate variability for risk stratification.” Circulation 109, no. 8 (March 2, 2004): 990–96. https://doi.org/10.1161/01.CIR.0000117090.01718.2A.
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  - Singer, Igor, Hussein Al-Khalidi, Imran Niazi, Patrick Tchou, Tony Simmons, Richard Henthorn, Michael Holroyde, and Jose Brum. “Azimilide decreases recurrent ventricular tachyarrhythmias in patients with implantable cardioverter defibrillators.” J Am Coll Cardiol 43, no. 1 (January 7, 2004): 39–43. https://doi.org/10.1016/j.jacc.2003.07.033.
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  - Al-Khalidi, H. R., A. J. Camm, J. M. Brum, M. Ruda, P. J. Schwartz, M. J. Spyt, C. M. Pratt, and M. J. Holroyde. “Low heart rate variability (triangular index method) predicts mortality independent of beta-blocker usage, LVEF, and other factors: ALIVE trial early findings.” European Heart Journal 22 (September 1, 2001): 701–701.
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  - Al-Khalidi, H. R., C. M. Pratt, J. M. Brum, A. J. Camm, P. J. Schwartz, M. J. Holroyde, C. M. Hislop, and U. Elkayam. “Baseline characteristics that identify patients at high risk of death following myocardial infarction. Preliminary findings from the ALIVE trial.” European Heart Journal 22 (September 1, 2001): 700–700.
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  - Al-Khalidi, H. R., J. M. Brum, R. Karam, A. J. Camm, E. Sonnenblick, P. J. Schwartz, W. Ruzyllo, M. J. Holroyde, and C. M. Pratt. “The ALIVE study: heart rate variability prospectively identifies patients at high risk of death after myocardial infarction.” European Heart Journal 22 (September 1, 2001): 696-+.
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  - Brooks, R. R., A. P. Drexler, A. E. Maynard, H. Al-Khalidi, and D. R. Kostreva. “Proarrhythmia of azimilide and other class III antiarrhythmic agents in the adrenergically stimulated rabbit.” Proc Soc Exp Biol Med 223, no. 2 (February 2000): 183–89. https://doi.org/10.1046/j.1525-1373.2000.22325.x.
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  - Corey, A., H. Al-Khalidi, C. Brezovic, S. Marcello, N. Parekh, K. Taylor, and R. Karam. “Azimilide pharmacokinetics and pharmacodynamics upon multiple oral dosing.” Biopharm Drug Dispos 20, no. 2 (March 1999): 59–68. https://doi.org/10.1002/(sici)1099-081x(199903)20:2<59::aid-bdd155>3.0.co;2-6.
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  - Corey, A., H. Al-Khalidi, C. Brezovic, S. Marcello, N. Parekh, K. Taylor, and R. Karam. “Azimilide pharmacokinetics and pharmacodynamics upon multiple oral dosing.” Clinical Pharmacology and Therapeutics 61, no. 2 (December 1, 1997): 205.
  - Al-Khalidi, H. R., and D. J. Schnell. “Application of a continuous-time Markov chain to a preclinical study.” Drug Information Journal 31, no. 2 (1997): 607–13.
  - Shen, L. Z., and H. R. Al-Khalidi. “Application of boundary calculation methodologies to group sequential testing in general parametric models.” Communications in Statistics Theory and Methods 26, no. 9 (January 1, 1997): 2173–90. https://doi.org/10.1080/03610929708832040.
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  - Drexler, A. P., H. Ai-Khalidi, A. E. Maynard, N. C. Johnson, R. L. Joroensen, R. R. Brooks, and P. R. Kostreva. “Comparison of azimilide dihydrochloride (NE-10064) and selected class III antiarrhythmic agents in a rabbit model of proarrhythmia.” Faseb Journal 10, no. 3 (December 1, 1996).
  - Brint, S. U., H. R. Al-Khalidi, B. Vatel, and D. B. Hier. “MCA flow asymmetry is a marker for cerebrovascular disease.” Neurol Res 18, no. 2 (April 1996): 163–67. https://doi.org/10.1080/01616412.1996.11740396.
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  - Al-Khalidi, H. R. “On the misspecification of a lognormal distribution.” Communications in Statistics Theory and Methods 23, no. 8 (January 1, 1994): 2351–65. https://doi.org/10.1080/03610929408831391.
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  - Al-Khalidi, H. R., and A. R. Parsa. “Some Aspects of Maximum Likelihood Estimation of Multistage Cancer Dose-Response Models with Application.” Communications in Statistics Theory and Methods 22, no. 12 (January 1, 1993): 3377–92. https://doi.org/10.1080/03610929308831222.
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  - Holiday, D. B., and J. W. McLarty. “Comparing time trends in a two-arm longitudinal study with an ordinal categorical response.” Communications in Statistics Theory and Methods 22, no. 12 (January 1, 1993): 3569–90. https://doi.org/10.1080/03610929308831233.
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  - Al-Khalidi, H. R., and L. J. Hwang. “Some pitfalls of tests of separate families of hypotheses: Normality vs. lognormality.” Communications in Statistics Theory and Methods 20, no. 8 (January 1, 1991): 2505–28. https://doi.org/10.1080/03610929108830647.
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- Conference Papers
  - Packer, D. L., K. H. Monahan, J. P. Piccini, H. R. Al-Khalidi, A. P. Silverstein, J. E. Poole, T. D. Bahnson, and D. B. Mark. “Impact of treatment strategies for AF on the progression and regression of AF type in the CABANA trial.” In European Heart Journal, 41:680–680, 2020.
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  - Monahan, K. H., T. J. Bunch, J. E. Poole, T. D. Bahnson, H. R. Al-Khalidi, A. P. Silverstein, D. B. Mark, K. L. Lee, and D. L. Packer. “Impact of AF type on the outcome of atrial fibrillation ablation: insights from the CABANA trial.” In European Heart Journal, 40:182–182. OXFORD UNIV PRESS, 2019.
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  - Poole, J., A. M. Russo, Y. M. Cha, K. H. Monahan, H. R. Al-Khalidi, A. P. Silverstein, T. D. Bahnson, D. B. Mark, K. L. Lee, and D. L. Packer. “Outcomes of catheter ablation for atrial fibrillation based on sex: data from the cabana trial.” In European Heart Journal, 40:1776–1776. OXFORD UNIV PRESS, 2019.
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  - Doenst, Torsten, Haissa Haddad, Amanda Stebbins, James A. Hill, Eric J. Velazquez, Kerry L. Lee, Jean L. Rouleau, et al. “Renal Function and Coronary Bypass Surgery in Patients With Ischemic Heart Failure - Insights From the STICH Trial.” In Circulation, Vol. 138, 2018.
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  - Jollis, James G., Hussein R. Al-Khalidi, Mayme L. Roettig, Lisa Monk, Peter B. Berger, Claire Corbett, Shannon Doerfler, et al. “Regional STEMI Systems of Care: Results of the Mission: Lifeline STEMI ACCELERATOR-2 Study.” In Circulation, 136:E461–62. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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  - Vinereanu, D., H. R. Al-Khalidi, M. P. Rao, R. L. Lopes, C. M. Bahit, A. O. Ciobanu, S. D. Pokorney, et al. “Determinants of antithrombotic treatment of patients with AF: baseline characteristics from a clustered randomized trial to IMProve treatment with AntiCoagulanTs in patients with AF (IMPACT-AF).” In European Heart Journal, 38:781–82. OXFORD UNIV PRESS, 2017.
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  - Lee, Kerry L., Rhonda S. Roberts, Daniel B. Mark, Hussein R. Al-Khalidi, Robin Boineau, Yves Rosenberg, Mario Stylianou, and Gervasio A. Lamas. “Behind the Looking Glass: Comparing Time to First Event versus Multiple Events Analyses in a Post-myocardial Infarction Clinical Trial.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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  - Lu, Michael T., Pamela S. Douglas, James E. Udelson, Elizabeth C. Adami, Brian B. Ghoshhajra, Michael H. Picard, Rhonda Roberts, et al. “Safety of Anatomic versus Functional Diagnostic Testing: Insights From the PROMISE Trial (PROspective Multicenter Imaging Study for Evaluation of Chest Pain).” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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  - Sherwood, Matthew W., Hussein R. Al-Khalidi, James G. Jollis, Mayme L. Roettig, Peter B. Berger, Claire C. Corbett, Harold L. Dauerman, et al. “Developing Regional STEMI Systems of Care: Final Results of the Mission: Lifeline STEMI ACCELERATOR Study.” In Circulation, 130:2111–2111, 2014.
  - Garber, Adam M., Robert J. Mentz, Linda K. Shaw, Hussein R. Al-Khalidi, Mona Fiuzat, Christopher O’Connors, and Eric J. Velazquez. “Predictors of Left Ventricular Thrombus Following ST-Segment Elevation Myocardial Infarction: Findings From the Duke Databank of Cardiovascular Disease and the Duke Echocardiography Databank.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Granger, Christopher B., Lisa M. Monk, Mayme L. Roettig, Hussein R. Al-Khalidi, Robert J. Applegate, Claire C. Corbett, J. L. Garvey, William R. Hathawy, B. H. Wilson, and James G. Jollis. “State-Wide Care is Improved in the Reperfusion of Acute MI in Carolina Emergency Department Emergency Response (RACE-ER) Systems Improvement Program.” In Circulation, 122:2223–24. LIPPINCOTT WILLIAMS & WILKINS, 2010.
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  - Dorian, P., H. R. Al-khalidi, S. H. Hohnloser, J. M. Brum, D. S. Tatla, M. van der Laan, and C. M. Pratt. “Analysis of all recurrent events is superior to the time-to-first event in assessment of drug therapy to prevent ICD therapies.” In European Heart Journal, 26:268–69. OXFORD UNIV PRESS, 2005.
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  - Dorian, P., S. Hohnloser, H. R. Al-Khalidi, J. M. Brum, M. Borggrefe, D. S. Tatla, J. Brachmann, et al. “SHock Inhibition Evaluation with AzimiLiDe (SHIELD): A randomized placebo controlled trial of azimilide in reducing ICD therapies.” In Circulation, 111:1726–1726. LIPPINCOTT WILLIAMS & WILKINS, 2005.
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