Recent Publications
Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales.
Journal Article JACS Au · November 25, 2024 Enterobacterales, a large order of Gram-negative bacteria, including Escherichia coli and Klebsiella pneumoniae, are major causes of urinary tract and gastrointestinal infections, pneumonia, and other diseases in healthcare settings and communities. ESBL-p ... Full text Link to item CiteInhibition of Androgen Receptor Exposes Replication Stress Vulnerability in Prostate Cancer
Preprint · October 11, 2024 Full text Cite4′-Selenonucleosides: Regio- and Stereoselective Synthesis of Novel Ribavirin and Acadesine Analogs as Anti-Hepatitis C Virus (HCV) Agents
Journal Article Asian Journal of Organic Chemistry · November 1, 2021 Intrigued by the biological activity of 2′-C-methylribofuranosyl nucleosides, and ribavirin/acadesine, based on the bioisosteric rationale between oxygen and selenium, we herein report a design and synthesis of the 2′-C-methyl-4′-seleno-ribavirin and -acad ... Full text CiteRecent Grants
LpxH Inhibitors as Novel Therapeutics Against Multidrug-resistant Enterobacterales
ResearchGraduate Student · Awarded by National Institutes of Health · 2025 - 2030TRPM8 in eye health and disease
ResearchGraduate Student · Awarded by National Institutes of Health · 2020 - 2029Inhibiting Rev1-mediated DNA translesion synthesis for cancer therapy
ResearchGraduate Student · Awarded by National Cancer Institute · 2024 - 2028View All Grants