Recent Publications
REV1 inhibition enhances trinucleotide repeat mutagenesis.
Journal Article bioRxiv · September 16, 2025 Trinucleotide repeat (TNR) instability has been implicated in the pathogenesis of numerous neurodegenerative disorders. Because TNR instability causes mutagenesis of the underlying gene, we refer to the repeat instability phenomenon as TNR mutagenesis in t ... Full text Link to item CiteAsymmetric Total Synthesis of 4,9,10-Trihydroxyguaia-11(13)en-12,6-olide and Discovery of Its Anticancer Activity against Atypical Teratoid Rhabdoid Tumor.
Journal Article ACS Cent Sci · July 23, 2025 The guaianolide family of sesquiterpene lactones is known for its distinctive structural features and diverse biological activities. 4,9,10-Trihydroxyguaia-11(13)-en-12,6-olide, with an underdetermined absolute stereochemistry (1 or ent-1), is a newly iden ... Full text Link to item CiteDesign and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales.
Journal Article JACS Au · November 25, 2024 Enterobacterales, a large order of Gram-negative bacteria, including Escherichia coli and Klebsiella pneumoniae, are major causes of urinary tract and gastrointestinal infections, pneumonia, and other diseases in healthcare settings and communities. ESBL-p ... Full text Link to item CiteRecent Grants
LpxH Inhibitors as Novel Therapeutics Against Multidrug-resistant Enterobacterales
ResearchGraduate Student · Awarded by National Institutes of Health · 2025 - 2030TRPM8 in eye health and disease
ResearchGraduate Student · Awarded by National Institutes of Health · 2020 - 2029Inhibiting Rev1-mediated DNA translesion synthesis for cancer therapy
ResearchGraduate Student · Awarded by National Cancer Institute · 2024 - 2028View All Grants