Scholars@Duke
Irma Husain

Irma Husain

Assistant Professor of Medicine
Medicine, Nephrology

Selected Publications

Murine kidney transplant outcome is best measured by transdermal glomerular filtration rate.

Journal Article Am J Transplant · December 2024 Mouse kidney transplantation provides a powerful preclinical model for the study of kidney transplant alloimmunity. However, accurate measurement of graft function is difficult because of the inaccuracy of traditional surrogate markers serum creatinine and ... Full text Link to item Cite

AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival.

Conference JCI Insight · March 8, 2024 Innate immune cells are important in the initiation and potentiation of alloimmunity in transplantation. Immediately upon organ anastomosis and reperfusion, recipient monocytes enter the graft from circulation and differentiate to inflammatory macrophages ... Full text Link to item Cite

Novel Approaches to Immunomodulation for Solid Organ Transplantation.

Journal Article Annu Rev Med · January 29, 2024 Despite significant advances in the field of transplantation in the past two decades, current clinically available therapeutic options for immunomodulation remain fairly limited. The advent of calcineurin inhibitor-based immunosuppression has led to signif ... Full text Link to item Cite

Single cell transcriptomics of mouse kidney transplants reveals a myeloid cell pathway for transplant rejection.

Journal Article JCI Insight · October 15, 2020 Myeloid cells are increasingly recognized as major players in transplant rejection. Here, we used a murine kidney transplantation model and single cell transcriptomics to dissect the contribution of myeloid cell subsets and their potential signaling pathwa ... Full text Open Access Link to item Cite

Proteinuric kidney diseases: A podocyte's slit diaphragm and cytoskeleton approach

Journal Article Frontiers in Medicine · January 1, 2018 Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms associated with significant losses of protein in the urine. The glomerular filtration barrier (GFB), comprised of the three important layers, the fenestrated glomerul ... Full text Cite