Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Yale University 1995
  • M.S., University of Chicago 1989
  • B.S., University of Chicago 1987
• 

  Duke Appointment History

  • Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1996 - 2019
  • Associate Research Professor of Statistical Science, Statistical Science, Trinity College of Arts & Sciences 2007 - 2017
  • Assistant Research Professor, Statistical Science, Trinity College of Arts & Sciences 2001 - 2007
  • Assistant Research Professor, Biostatistics & Bioinformatics, Basic Science Departments 2000 - 2006
• Research
• 

  Selected Grants

  • MAYO Clinic Breast Cancer SPORE-Project 1: Cancer risks for mutations in breast cancer awarded by Mayo Clinic 2005 - 2021
  • Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2020
  • Biodosimetry High-Throughput Test 2017 - 2019
  • Discovery of Novel Rare Variants as Ovarian Cancer Susceptibility Factors 2016 - 2019
  • OC3 Subtype-Specific Risk Model 2018
  • Early child care and risk of obesity 2015 - 2018
  • BRCA 1 and BRCA2 missense mutations and breast cancer risk awarded by Mayo Clinic 2013 - 2018
  • Early child care and risk of obesity awarded by National Institutes of Health 2012 - 2017
  • Epidemiologic factors and survival by molecular subtypes of ovarian cancer 2015 - 2017
  • Epidemiologic factors and survival by molecular subtypes of ovarian cancer 2013 - 2017
  • Nitrosative Stress and Symptoms During Childhood Leukemia Treatment 2014 - 2017
  • Discovery of Novel Rare Variants as Ovarian Cancer Susceptibility Factors 2015 - 2016
  • Atlantic Breast and Gynecologic Clinical Validation Center awarded by National Institutes of Health 1999 - 2016
  • Models for Consortium Level Analysis of GxE Interaction in Complex Disease awarded by National Institutes of Health 2012 - 2015
  • Obesity and deregulation of imprinted genes in early life awarded by National Institutes of Health 2010 - 2015
  • Epidemiology of Ovarian Cancer in African-American Women awarded by National Institutes of Health 2010 - 2015
  • Epigenetic influence on early childhood self-regulation capacities and obesity awarded by National Institutes of Health 2011 - 2014
  • FitFab 4 Survivors awarded by National Institutes of Health 2011 - 2014
  • Disparities in cervical cancer precursors and deregulation of imprinted genes awarded by National Institutes of Health 2010 - 2014
  • The Molecular Epidemiology Of Ovarian Cancer awarded by National Institutes of Health 1998 - 2012
  • Analysis of Glutathione S-transferase polymorphism, Lifestyle & Cancer Risk awarded by National Institutes of Health 2010 - 2012
  • Bayesian Modeling and Optimal Design for Studies of Gene-Environment Association awarded by National Institutes of Health 2007 - 2011
  • Ovarian Failure Among Hysterectomized Women awarded by National Institutes of Health 2003 - 2010
  • Phase II trial of Cetuximab & Carboplatin in Basal-like Breast Cancer awarded by National Institutes of Health 1995 - 2008
  • Carolina and Georgia Genetics Network Center awarded by National Institutes of Health 1998 - 2008
  • Carolina and Georgia Genetics Network Center awarded by National Institutes of Health 1998 - 2004
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Reid, Brett M., Jennifer B. Permuth, Y Ann Chen, Brooke L. Fridley, Edwin S. Iversen, Zhihua Chen, Heather Jim, et al. “Genome-wide Analysis of Common Copy Number Variation and Epithelial Ovarian Cancer Risk..” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 28, no. 7 (July 2019): 1117–26. https://doi.org/10.1158/1055-9965.epi-18-0833.
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    • Fernandes, Vanessa C., Volha A. Golubeva, Giuliano Di Pietro, Cara Shields, Kwabena Amankwah, Thales C. Nepomuceno, Giuliana de Gregoriis, et al. “Impact of amino acid substitutions at secondary structures in the BRCT domains of the tumor suppressor BRCA1: Implications for clinical annotation..” The Journal of Biological Chemistry 294, no. 15 (April 2019): 5980–92. https://doi.org/10.1074/jbc.ra118.005274.
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    • Buckley, Melissa A., Nicholas T. Woods, Jonathan P. Tyrer, Gustavo Mendoza-Fandiño, Kate Lawrenson, Dennis J. Hazelett, Hamed S. Najafabadi, et al. “Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus..” Cancer Research 79, no. 3 (February 2019): 467–81. https://doi.org/10.1158/0008-5472.can-17-3864.
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    • Hart, Steven N., Tanya Hoskin, Hermela Shimelis, Raymond M. Moore, Bingjian Feng, Abigail Thomas, Noralane M. Lindor, et al. “Comprehensive annotation of BRCA1 and BRCA2 missense variants by functionally validated sequence-based computational prediction models..” Genetics in Medicine : Official Journal of the American College of Medical Genetics 21, no. 1 (January 2019): 71–80. https://doi.org/10.1038/s41436-018-0018-4.
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    • Iversen, Edwin S., Janice M. McCarthy, Kirsten Bell Burdett, Gary Lipton, Gary Phillips, Holly Dressman, Joel Ross, and Nelson Chao. “Bridging the gaps: using an NHP model to predict single dose radiation absorption in humans..” Int J Radiat Biol, October 29, 2018, 1–10. https://doi.org/10.1080/09553002.2018.1532614.
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    • Kelemen, Linda E., Madalene Earp, Brooke L. Fridley, Georgia Chenevix-Trench, Georgia Australian Ovarian Cancer Study Group, Peter A. Fasching, Matthias W. Beckmann, et al. “rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology..” Int J Mol Sci 19, no. 9 (August 21, 2018). https://doi.org/10.3390/ijms19092473.
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    • Guidugli, Lucia, Hermela Shimelis, David L. Masica, Vernon S. Pankratz, Gary B. Lipton, Namit Singh, Chunling Hu, et al. “Assessment of the Clinical Relevance of BRCA2 Missense Variants by Functional and Computational Approaches..” American Journal of Human Genetics 102, no. 2 (February 2018): 233–48. https://doi.org/10.1016/j.ajhg.2017.12.013.
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    • Earp, Madalene, Jonathan P. Tyrer, Stacey J. Winham, Hui-Yi Lin, Ganna Chornokur, Joe Dennis, Katja K. H. Aben, et al. “Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility..” Plos One 13, no. 7 (2018). https://doi.org/10.1371/journal.pone.0197561.
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    • “RE: “RISK PREDICTION FOR EPITHELIAL OVARIAN CANCER IN 11 UNITED STATES–BASED CASE-CONTROL STUDIES: INCORPORATION OF EPIDEMIOLOGIC RISK FACTORS AND 17 CONFIRMED GENETIC LOCI”.” American Journal of Epidemiology 186, no. 1 (July 1, 2017): 130–130. https://doi.org/10.1093/aje/kwx151.
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    • Phelan, Catherine M., Karoline B. Kuchenbaecker, Jonathan P. Tyrer, Siddhartha P. Kar, Kate Lawrenson, Stacey J. Winham, Joe Dennis, et al. “Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer..” Nat Genet 49, no. 5 (May 2017): 680–91. https://doi.org/10.1038/ng.3826.
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    • Sosa-Pagán, Jason O., Edwin S. Iversen, and Jörg Grandl. “TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity..” Sci Rep 7, no. 1 (April 3, 2017). https://doi.org/10.1038/s41598-017-00636-4.
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    • Benjamin Neelon, Sara E., Truls Østbye, Gary G. Bennett, Richard M. Kravitz, Shayna M. Clancy, Marissa Stroo, Edwin Iversen, and Cathrine Hoyo. “Cohort profile for the Nurture Observational Study examining associations of multiple caregivers on infant growth in the Southeastern USA..” Bmj Open 7, no. 2 (February 8, 2017). https://doi.org/10.1136/bmjopen-2016-013939.
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    • Mayhew, Michael B., Edwin S. Iversen, and Alexander J. Hartemink. “Characterization of dependencies between growth and division in budding yeast..” Journal of the Royal Society, Interface 14, no. 127 (February 2017). https://doi.org/10.1098/rsif.2016.0993.
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    • Southey, Melissa C., David E. Goldgar, Robert Winqvist, Katri Pylkäs, Fergus Couch, Marc Tischkowitz, William D. Foulkes, et al. “PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS..” J Med Genet 53, no. 12 (December 2016): 800–811. https://doi.org/10.1136/jmedgenet-2016-103839.
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    • Zhang, Ying, Isaac Nault, Sorin Mitran, Edwin S. Iversen, and Pei Zhong. “Effects of Stone Size on the Comminution Process and Efficiency in Shock Wave Lithotripsy..” Ultrasound in Medicine & Biology 42, no. 11 (November 2016): 2662–75. https://doi.org/10.1016/j.ultrasmedbio.2016.06.018.
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    • Hampras, Shalaka S., Lara E. Sucheston-Campbell, Rikki Cannioto, Jenny Chang-Claude, Francesmary Modugno, Thilo Dörk, Peter Hillemanns, et al. “Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer..” Oncotarget 7, no. 43 (October 25, 2016): 69097–110. https://doi.org/10.18632/oncotarget.10215.
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    • Clyde, Merlise A., Rachel Palmieri Weber, Edwin S. Iversen, Elizabeth M. Poole, Jennifer A. Doherty, Marc T. Goodman, Roberta B. Ness, et al. “Risk Prediction for Epithelial Ovarian Cancer in 11 United States-Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci..” Am J Epidemiol 184, no. 8 (October 15, 2016): 579–89. https://doi.org/10.1093/aje/kww091.
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    • Permuth, Jennifer B., Ailith Pirie, Y. Ann Chen, Hui-Yi Lin, Brett M. Reid, Zhihua Chen, Alvaro Monteiro, et al. “Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk..” Hum Mol Genet 25, no. 16 (August 15, 2016): 3600–3612. https://doi.org/10.1093/hmg/ddw196.
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    • Fuemmeler, Bernard F., Lin Wang, Edwin S. Iversen, Rachel Maguire, Susan K. Murphy, and Cathrine Hoyo. “Association between Prepregnancy Body Mass Index and Gestational Weight Gain with Size, Tempo, and Velocity of Infant Growth: Analysis of the Newborn Epigenetic Study Cohort..” Child Obes 12, no. 3 (June 2016): 210–18. https://doi.org/10.1089/chi.2015.0253.
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    • Winham, Stacey J., Ailith Pirie, Yian Ann Chen, Melissa C. Larson, Zachary C. Fogarty, Madalene A. Earp, Hoda Anton-Culver, et al. “Investigation of Exomic Variants Associated with Overall Survival in Ovarian Cancer..” Cancer Epidemiol Biomarkers Prev 25, no. 3 (March 2016): 446–54. https://doi.org/10.1158/1055-9965.EPI-15-0240.
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    • Zhong, Jianling, Kaixuan Luo, Peter S. Winter, Gregory E. Crawford, Edwin S. Iversen, and Alexander J. Hartemink. “Mapping nucleosome positions using DNase-seq..” Genome Res 26, no. 3 (March 2016): 351–64. https://doi.org/10.1101/gr.195602.115.
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    • Earp, Madalene, Stacey J. Winham, Nicholas Larson, Jennifer B. Permuth, Hugues Sicotte, Jeremy Chien, Hoda Anton-Culver, et al. “A targeted genetic association study of epithelial ovarian cancer susceptibility..” Oncotarget 7, no. 7 (February 16, 2016): 7381–89. https://doi.org/10.18632/oncotarget.7121.
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    • French, Juliet D., Sharon E. Johnatty, Yi Lu, Jonathan Beesley, Bo Gao, Murugan Kalimutho, Michelle J. Henderson, et al. “Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer..” Oncotarget 7, no. 6 (February 9, 2016): 6353–68. https://doi.org/10.18632/oncotarget.7047.
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    • Fuemmeler, Bernard F., Chien-Ti Lee, Adelheid Soubry, Edwin S. Iversen, Zhiqing Huang, Amy P. Murtha, Joellen M. Schildkraut, Randy L. Jirtle, Susan K. Murphy, and Cathrine Hoyo. “DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament..” Genet Epigenet 8 (2016): 59–67. https://doi.org/10.4137/GEG.S40538.
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    • Lee, Alice W., Claire Templeman, Douglas A. Stram, Jonathan Beesley, Jonathan Tyrer, Andrew Berchuck, Paul P. Pharoah, Georgia Chenevix-Trench, Celeste Leigh Pearce, and Celeste Leigh Ovarian Cancer Association Consortium. “Evidence of a genetic link between endometriosis and ovarian cancer..” Fertil Steril 105, no. 1 (January 2016). https://doi.org/10.1016/j.fertnstert.2015.09.023.
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    • Scarbrough, Peter M., Rachel Palmieri Weber, Edwin S. Iversen, Yonathan Brhane, Christopher I. Amos, Peter Kraft, Rayjean J. Hung, et al. “A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer..” Cancer Epidemiol Biomarkers Prev 25, no. 1 (January 2016): 193–200. https://doi.org/10.1158/1055-9965.EPI-15-0649.
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    • Woods, Nicholas T., Rebekah Baskin, Volha Golubeva, Ankita Jhuraney, Giuliana De-Gregoriis, Tereza Vaclova, David E. Goldgar, et al. “Functional assays provide a robust tool for the clinical annotation of genetic variants of uncertain significance..” Npj Genomic Medicine 1 (January 2016). https://doi.org/10.1038/npjgenmed.2016.1.
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    • Bolton, K. L., J. Tyrer, H. Song, S. J. Ramus, M. Notaridou, C. Jones, T. Sher, et al. “Erratum: Common variants at 19p13 are associated with susceptibility to ovarian cancer (Nature Genetics (2010) 42 (880-884)).” Nature Genetics 48, no. 1 (December 29, 2015). https://doi.org/10.1038/ng0116-101b.
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    • Amankwah, Ernest K., Hui-Yi Lin, Jonathan P. Tyrer, Kate Lawrenson, Joe Dennis, Ganna Chornokur, Katja K. H. Aben, et al. “Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk..” Genet Epidemiol 39, no. 8 (December 2015): 689–97. https://doi.org/10.1002/gepi.21921.
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    • Johnatty, Sharon E., Jonathan P. Tyrer, Siddhartha Kar, Jonathan Beesley, Yi Lu, Bo Gao, Peter A. Fasching, et al. “Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium..” Clin Cancer Res 21, no. 23 (December 1, 2015): 5264–76. https://doi.org/10.1158/1078-0432.CCR-15-0632.
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    • Lawrenson, Kate, Edwin S. Iversen, Jonathan Tyrer, Rachel Palmieri Weber, Patrick Concannon, Dennis J. Hazelett, Qiyuan Li, et al. “Common variants at the CHEK2 gene locus and risk of epithelial ovarian cancer..” Carcinogenesis 36, no. 11 (November 2015): 1341–53. https://doi.org/10.1093/carcin/bgv138.
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    • Kar, Siddhartha P., Jonathan P. Tyrer, Qiyuan Li, Kate Lawrenson, Katja K. H. Aben, Hoda Anton-Culver, Natalia Antonenkova, et al. “Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk..” Cancer Epidemiol Biomarkers Prev 24, no. 10 (October 2015): 1574–84. https://doi.org/10.1158/1055-9965.EPI-14-1270.
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    • Lawrenson, Kate, Qiyuan Li, Siddhartha Kar, Ji-Heui Seo, Jonathan Tyrer, Tassja J. Spindler, Janet Lee, et al. “Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer..” Nat Commun 6 (September 22, 2015). https://doi.org/10.1038/ncomms9234.
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    • Kelemen, Linda E., Kate Lawrenson, Jonathan Tyrer, Qiyuan Li, Janet M. Lee, Ji-Heui Seo, Catherine M. Phelan, et al. “Genome-wide significant risk associations for mucinous ovarian carcinoma..” Nat Genet 47, no. 8 (August 2015): 888–97. https://doi.org/10.1038/ng.3336.
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    • Caves, Eleanor M., Martin Stevens, Edwin S. Iversen, and Claire N. Spottiswoode. “Hosts of avian brood parasites have evolved egg signatures with elevated information content..” Proceedings. Biological Sciences 282, no. 1810 (July 2015). https://doi.org/10.1098/rspb.2015.0598.
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    • Coetzee, Simon G., Howard C. Shen, Dennis J. Hazelett, Kate Lawrenson, Karoline Kuchenbaecker, Jonathan Tyrer, Suhn K. Rhie, et al. “Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci..” Hum Mol Genet 24, no. 13 (July 1, 2015): 3595–3607. https://doi.org/10.1093/hmg/ddv101.
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    • Lee, Alice W., Jonathan P. Tyrer, Jennifer A. Doherty, Douglas A. Stram, Jolanta Kupryjanczyk, Agnieszka Dansonka-Mieszkowska, Joanna Plisiecka-Halasa, et al. “Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study..” Gynecol Oncol 136, no. 3 (March 2015): 542–48. https://doi.org/10.1016/j.ygyno.2014.12.017.
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    • Kuchenbaecker, Karoline B., Susan J. Ramus, Jonathan Tyrer, Andrew Lee, Howard C. Shen, Jonathan Beesley, Kate Lawrenson, et al. “Identification of six new susceptibility loci for invasive epithelial ovarian cancer..” Nat Genet 47, no. 2 (February 2015): 164–71. https://doi.org/10.1038/ng.3185.
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    • Marks, Jeffrey R., Karen S. Anderson, Paul Engstrom, Andrew K. Godwin, Laura J. Esserman, Gary Longton, Edwin S. Iversen, Anu Mathew, Christos Patriotis, and Margaret S. Pepe. “Construction and analysis of the NCI-EDRN breast cancer reference set for circulating markers of disease..” Cancer Epidemiol Biomarkers Prev 24, no. 2 (February 2015): 435–41. https://doi.org/10.1158/1055-9965.EPI-14-1178.
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    • Chornokur, Ganna, Hui-Yi Lin, Jonathan P. Tyrer, Kate Lawrenson, Joe Dennis, Ernest K. Amankwah, Xiaotao Qu, et al. “Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk..” Plos One 10, no. 6 (2015). https://doi.org/10.1371/journal.pone.0128106.
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    • Jim, Heather S. L., Hui-Yi Lin, Jonathan P. Tyrer, Kate Lawrenson, Joe Dennis, Ganna Chornokur, Zhihua Chen, et al. “Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC)..” J Genet Genome Res 2, no. 2 (2015).
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    • Kelemen, Linda E., Kathryn L. Terry, Marc T. Goodman, Penelope M. Webb, Elisa V. Bandera, Valerie McGuire, Mary Anne Rossing, et al. “Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk..” Mol Nutr Food Res 58, no. 10 (October 2014): 2023–35. https://doi.org/10.1002/mnfr.201400068.
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    • Tang, Xiaohu, Chao-Chieh Lin, Ivan Spasojevic, Edwin S. Iversen, Jen-Tsan Chi, and Jeffrey R. Marks. “A joint analysis of metabolomics and genetics of breast cancer..” Breast Cancer Res 16, no. 4 (August 5, 2014). https://doi.org/10.1186/s13058-014-0415-9.
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    • Hoyo, Cathrine, Anne Kjersti Daltveit, Edwin Iversen, Sara E. Benjamin-Neelon, Bernard Fuemmeler, Joellen Schildkraut, Amy P. Murtha, et al. “Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort..” Epigenetics 9, no. 8 (August 2014): 1120–30. https://doi.org/10.4161/epi.29332.
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    • Hedditch, Ellen L., Bo Gao, Amanda J. Russell, Yi Lu, Catherine Emmanuel, Jonathan Beesley, Sharon E. Johnatty, et al. “ABCA transporter gene expression and poor outcome in epithelial ovarian cancer..” J Natl Cancer Inst 106, no. 7 (July 2014). https://doi.org/10.1093/jnci/dju149.
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    • Earp, Madalene A., Linda E. Kelemen, Anthony M. Magliocco, Kenneth D. Swenerton, Georgia Chenevix-Trench, Georgia Australian Cancer Study, Georgia Australian Ovarian Cancer Study Group, et al. “Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA..” Hum Genet 133, no. 5 (May 2014): 481–97. https://doi.org/10.1007/s00439-013-1383-3.
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    • Carvalho, Renato S., Renata B. V. Abreu, Aneliya Velkova, Sylvia Marsillac, Renato S. Rodarte, Guilherme Suarez-Kurtz, Edwin S. Iversen, Alvaro N. A. Monteiro, and Marcelo A. Carvalho. “Probing structure-function relationships in missense variants in the carboxy-terminal region of BRCA1..” Plos One 9, no. 5 (January 2014). https://doi.org/10.1371/journal.pone.0097766.
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    • Iversen, E. S., G. Lipton, M. A. Clyde, and A. N. A. Monteiro. “Functional Annotation Signatures of Disease Susceptibility Loci Improve SNP Association Analysis.” Bmc Genomics 15 (2014): 398–398. https://doi.org/10.1186/1471-2164-15-398.
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    • Iversen, E. S., G. Lipton, M. A. Clyde, and A. N. A. Monteiro. “Functional annotation signatures of disease susceptibility loci improve SNP association analysis.” Bmc Genomics 15, no. 1 (2014). https://doi.org/10.1186/1471-2164-15-398.
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    • Vidal, Adriana C., Sara E. Benjamin Neelon, Ying Liu, Abbas M. Tuli, Bernard F. Fuemmeler, Cathrine Hoyo, Amy P. Murtha, et al. “Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans..” Genet Epigenet 6 (2014): 37–44. https://doi.org/10.4137/GEG.S18067.
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    • Hutter, Carolyn M., Leah E. Mechanic, Nilanjan Chatterjee, Peter Kraft, Elizabeth M. Gillanders, and Elizabeth M. NCI Gene-Environment Think Tank. “Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report..” Genetic Epidemiology 37, no. 7 (November 2013): 643–57. https://doi.org/10.1002/gepi.21756.
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    • Schildkraut, Joellen M., Edwin S. Iversen, Lucy Akushevich, Regina Whitaker, Rex C. Bentley, Andrew Berchuck, and Jeffrey R. Marks. “Molecular signatures of epithelial ovarian cancer: analysis of associations with tumor characteristics and epidemiologic risk factors..” Cancer Epidemiol Biomarkers Prev 22, no. 10 (October 2013): 1709–21. https://doi.org/10.1158/1055-9965.EPI-13-0192.
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    • Vidal, A. C., S. K. Murphy, A. P. Murtha, J. M. Schildkraut, A. Soubry, Z. Huang, S. E. B. Neelon, et al. “Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring..” Int J Obes (Lond) 37, no. 7 (July 2013): 907–13. https://doi.org/10.1038/ijo.2013.47.
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    • Pearce, Celeste Leigh, Mary Anne Rossing, Alice W. Lee, Roberta B. Ness, Penelope M. Webb, Penelope M. for Australian Cancer Study (Ovarian Cancer), Penelope M. Australian Ovarian Cancer Study Group, et al. “Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer..” Cancer Epidemiol Biomarkers Prev 22, no. 5 (May 2013): 880–90. https://doi.org/10.1158/1055-9965.EPI-12-1030-T.
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    • Bojesen, Stig E., Karen A. Pooley, Sharon E. Johnatty, Jonathan Beesley, Kyriaki Michailidou, Jonathan P. Tyrer, Stacey L. Edwards, et al. “Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer..” Nat Genet 45, no. 4 (April 2013): 371-384e2. https://doi.org/10.1038/ng.2566.
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    • Grant, Delores J., Cathrine Hoyo, Lucy Akushevich, Edwin S. Iversen, Regina Whitaker, Jeffrey Marks, Andrew Berchuck, and Joellen M. Schildkraut. “Vitamin D receptor (VDR) polymorphisms and risk of ovarian cancer in Caucasian and African American women..” Gynecol Oncol 129, no. 1 (April 2013): 173–78. https://doi.org/10.1016/j.ygyno.2012.12.027.
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    • Pharoah, Paul D. P., Ya-Yu Tsai, Susan J. Ramus, Catherine M. Phelan, Ellen L. Goode, Kate Lawrenson, Melissa Buckley, et al. “GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer..” Nat Genet 45, no. 4 (April 2013): 362-370e2. https://doi.org/10.1038/ng.2564.
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    • Sfakianos, Gregory P., Edwin S. Iversen, Regina Whitaker, Liudmila Akushevich, Joellen M. Schildkraut, Susan K. Murphy, Jeffrey R. Marks, and Andrew Berchuck. “Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues..” Gynecol Oncol 129, no. 1 (April 2013): 159–64. https://doi.org/10.1016/j.ygyno.2012.12.030.
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    • Goode, Ellen L., Melissa DeRycke, Kimberly R. Kalli, Ann L. Oberg, Julie M. Cunningham, Matthew J. Maurer, Brooke L. Fridley, et al. “Inherited variants in regulatory T cell genes and outcome of ovarian cancer..” Plos One 8, no. 1 (2013). https://doi.org/10.1371/journal.pone.0053903.
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    • Permuth-Wey, Jennifer, Kate Lawrenson, Howard C. Shen, Aneliya Velkova, Jonathan P. Tyrer, Zhihua Chen, Hui-Yi Lin, et al. “Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31..” Nat Commun 4 (2013). https://doi.org/10.1038/ncomms2613.
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    • Shen, Hui, Brooke L. Fridley, Honglin Song, Kate Lawrenson, Julie M. Cunningham, Susan J. Ramus, Mine S. Cicek, et al. “Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer..” Nat Commun 4 (2013). https://doi.org/10.1038/ncomms2629.
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    • Vidal, A. C., S. K. Murphy, A. P. Murtha, J. M. Schildkraut, A. Soubry, Z. Huang, S. E. B. Neelon, et al. “Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring.” International Journal of Obesity 37, no. 7 (2013): 907–13. https://doi.org/10.1038/ijo.2013.47.
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    • Moorman, Patricia G., Edwin S. Iversen, P Kelly Marcom, Jeffrey R. Marks, Frances Wang, Frances Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Eunjung Lee, et al. “Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis..” Breast Cancer Res Treat 124, no. 2 (November 2010): 441–51. https://doi.org/10.1007/s10549-010-0842-y.
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    • Wilson, Melanie A., Edwin S. Iversen, Merlise A. Clyde, Scott C. Schmidler, and Joellen M. Schildkraut. “BAYESIAN MODEL SEARCH AND MULTILEVEL INFERENCE FOR SNP ASSOCIATION STUDIES..” Ann Appl Stat 4, no. 3 (September 1, 2010): 1342–64.
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    • Johnatty, Sharon E., Jonathan Beesley, Xiaoqing Chen, Stuart Macgregor, David L. Duffy, Amanda B. Spurdle, Anna deFazio, et al. “Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"..” Plos Genet 6, no. 7 (July 8, 2010). https://doi.org/10.1371/journal.pgen.1001016.
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    • Schildkraut, Joellen M., Edwin S. Iversen, Melanie A. Wilson, Merlise A. Clyde, Patricia G. Moorman, Rachel T. Palmieri, Regina Whitaker, Rex C. Bentley, Jeffrey R. Marks, and Andrew Berchuck. “Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer..” Plos One 5, no. 4 (April 8, 2010). https://doi.org/10.1371/journal.pone.0010061.
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    • Moorman, Patricia G., Joellen M. Schildkraut, Edwin S. Iversen, Evan R. Myers, Margaret Gradison, Nicolette Warren-White, and Frances Wang. “A prospective study of weight gain after premenopausal hysterectomy..” J Womens Health (Larchmt) 18, no. 5 (May 2009): 699–708. https://doi.org/10.1089/jwh.2008.1019.
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    • Orlando, David A., Edwin S. Iversen, Alexander J. Hartemink, and Steven B. Haase. “A branching process model for flow cytometry and budding index measurements in cell synchrony experiments..” The Annals of Applied Statistics 3, no. 4 (January 2009): 1521–41. https://doi.org/10.1214/09-AOAS264.
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    • Palmieri, Rachel T., Melanie A. Wilson, Edwin S. Iversen, Merlise A. Clyde, Brian Calingaert, Patricia G. Moorman, Charles Poole, et al. “Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women..” Cancer Epidemiol Biomarkers Prev 17, no. 12 (December 2008): 3567–72. https://doi.org/10.1158/1055-9965.EPI-08-0548.
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    • Goldgar, David E., Douglas F. Easton, Graham B. Byrnes, Amanda B. Spurdle, Edwin S. Iversen, Marc S. Greenblatt, and Marc S. IARC Unclassified Genetic Variants Working Group. “Genetic evidence and integration of various data sources for classifying uncertain variants into a single model..” Human Mutation 29, no. 11 (November 2008): 1265–72. https://doi.org/10.1002/humu.20897.
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    • Iversen, E. S., G. Parmigiani, and S. Chen. “Multiple model evaluation absent the gold standard through model combination.” Journal of the American Statistical Association 103, no. 483 (September 1, 2008): 897–909. https://doi.org/10.1198/016214507000001012.
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    • Orlando, David A., Charles Y. Lin, Allister Bernard, Jean Y. Wang, Joshua E. S. Socolar, Edwin S. Iversen, Alexander J. Hartemink, and Steven B. Haase. “Global control of cell-cycle transcription by coupled CDK and network oscillators..” Nature 453, no. 7197 (June 2008): 944–47. https://doi.org/10.1038/nature06955.
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    • Moorman, Patricia G., Brian Calingaert, Rachel T. Palmieri, Edwin S. Iversen, Rex C. Bentley, Susan Halabi, Andrew Berchuck, and Joellen M. Schildkraut. “Hormonal risk factors for ovarian cancer in premenopausal and postmenopausal women..” Am J Epidemiol 167, no. 9 (May 1, 2008): 1059–69. https://doi.org/10.1093/aje/kwn006.
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    • Iversen, E. S., G. Parmigiani, D. A. Berry, and J. M. Schildkraut. “Genetic Susceptibility and Survival: Application to Breast Cancer.” Journal of the American Statistical Association 95, no. 449 (March 1, 2000): 28–42. https://doi.org/10.1080/01621459.2000.10473896.
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    • Claus, E. B., J. Schildkraut, E. S. Iversen, D. Berry, and G. Parmigiani. “Effect of BRCA1 and BRCA2 on the association between breast cancer risk and family history..” J Natl Cancer Inst 90, no. 23 (December 2, 1998): 1824–29. https://doi.org/10.1093/jnci/90.23.1824.
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    • Schildkraut, J., E. S. Iversen Jr, G. Parmigiani, and D. Berry. “Prognostic Significance of Estimated BRCA1 and BRCA2 mutation status in women diagnosed with breast cancer.” Genetic Epidemiology, no. 14 (1997).
    • Iversen, E. S., and J. M. Lees. “A statistical technique for validating velocity models.” Bulletin of the Seismological Society of America 86, no. 6 (December 1, 1996): 1853–62.
    • Iversen Jr, E. S., and J. M. Lees. “A statistical technique for validating velocity models.” Bulletin of the Seismological Society of America 86, no. 60 (1996): 1853–62.
    • Iversen Jr., Edwin Severin. “A Spatial and Temporal Markov Random Field Model with Application to Real Estate Indices,” n.d.

  • Book Sections

    • Clydec, Merlise, and Edwin S. Iversen. “Bayesian model averaging in the M-open framework.” In Bayesian Theory and Applications, 483–98. Oxford University Press, 2013. https://doi.org/10.1093/acprof:oso/9780199695607.003.0024.
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  • Other Articles

    • Andrew, B., E. S. Iversen, J. M. Lancaster, H. K. Dressman, M. West, J. R. Nevins, J. R. Marks, and B. E. Miller. “Prediction of optimal versus suboptimal cytoreduction of advanced-stage serious ovarian cancer with the use of microarrays.” Women’S Oncology Review, September 1, 2004. https://doi.org/10.1080/14733400412331312585.
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  • Conference Papers

    • Moorman, P. G., J. M. Schildkraut, E. R. Myers, E. S. Iversen, N. Warren-White, and F. Wang. “Weight gain after pre-menopausal hysterectomy.” In American Journal of Epidemiology, 167:S32–S32. OXFORD UNIV PRESS INC, 2008.
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    • Berchuck, Andrew, Johnathan M. Lancaster, Edwin S. Iversen, Jingqin Luo, Douglas A. Levine, Jeffrey Boyd, Angeles Alvarez Secord, Jeffrey R. Marks, Joseph R. Nevins, and Holly Dressman. “Most early-stage serous ovarian cancers have gene expression profiles predictive of long-term survival.” In Gynecologic Oncology, 104:S15–16. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2007.
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• Teaching & Mentoring
• 

  Recent Courses

  • STA 470S: Introduction to Statistical Consulting 2019
  • STA 851: Statistical Consulting Workshop 2019
  • STA 493: Research Independent Study 2017

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