Overview
Bayesian statistical modeling with application to problems in genetic
epidemiology and cancer research; models for epidemiological risk
assessment, including hierarchical methods for combining related
epidemiological studies; ascertainment corrections for high risk
family data; analysis of high-throughput genomic data sets.
epidemiology and cancer research; models for epidemiological risk
assessment, including hierarchical methods for combining related
epidemiological studies; ascertainment corrections for high risk
family data; analysis of high-throughput genomic data sets.
Current Duke Appointments & Affiliations
Research Professor of Statistical Science
·
2017 - Present
Statistical Science,
Trinity College of Arts & Sciences
Recent Scholarly Works
Assessment of a Handheld Near-Infrared Light Device in Detecting Intracranial Hematomas in Mbarara, Uganda.
Journal article Neurosurgery · August 1, 2026 BACKGROUND AND OBJECTIVES: Traumatic brain injury (TBI) is one of the leading causes of mortality worldwide. Low- and middle-income countries have limited access to computed tomography scans (CT), which are essential in TBI care. The Infrascanner 2000™ is ... Full text Link to item CiteCombining multiplexed assays of variant effect for enhanced BRCA2 variant classification.
Journal article Nature communications · April 2026 Determining the clinical relevance of BRCA2 variants of uncertain significance is critical for informed risk management. Recently, two saturation genome editing studies assessed the functional effects of all single nucleotide variants in the BRCA2 C-termin ... Full text CiteTransposable elements contribute substantially to naturally occurring genetic lethality in Drosophila melanogaster.
Journal article PLoS biology · March 2026 Recessive lethal mutations are widespread across studied species, with estimates suggesting that each individual carries at least one. Numerous lethal alleles persist in wild populations at higher frequencies than expected given their extreme deleterious n ... Full text Open Access CiteRecent Grants
Computational Biology and Bioinformatics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2026 - 2031Myovascular Mechanisms of Cardiac Growth and Regeneration
ResearchCollaborator · Awarded by National Heart, Lung, and Blood Institute · 2022 - 2026Discovery of Novel Rare Variants as Ovarian Cancer Susceptibility Factors
ResearchCo Investigator · Awarded by MD Anderson Cancer Center · 2016 - 2022View All Grants
Education
Yale University ·
1995
Ph.D.
The University of Chicago ·
1989
M.S.
The University of Chicago ·
1987
B.S.