Overview
epidemiology and cancer research; models for epidemiological risk
assessment, including hierarchical methods for combining related
epidemiological studies; ascertainment corrections for high risk
family data; analysis of high-throughput genomic data sets.
Current Appointments & Affiliations
Research Professor of Statistical Science
·
2017 - Present
Statistical Science,
Trinity College of Arts & Sciences
Recent Publications
Functional evaluation and clinical classification of BRCA2 variants.
Journal Article Nature · February 2025 Germline BRCA2 loss-of function variants, which can be identified through clinical genetic testing, predispose to several cancers1-5. However, variants of uncertain significance limit the clinical utility of test results. Thus, there is a need f ... Full text Open Access CiteAn abundant mutualist can protect corals from multiple stressors.
Journal Article Proceedings. Biological sciences · February 2025 Mutualisms can increase the ability of foundation species to resist individual stressors, but it remains unclear whether mutualisms can also ameliorate co-occurring stressors for habitat-forming species. To examine whether a suspected mutualist could impro ... Full text CiteImprove time to anti-coagulation reversal for hemorrhagic strokes.
Journal Article J Stroke Cerebrovasc Dis · December 2024 BACKGROUND: Oral anticoagulation (OAC) is a risk factor for intracerebral hemorrhage (ICH) which is an important source of disability and mortality. OAC-associated ICH (OAC-ICH) patients have worse outcomes as compared to ICH patients not on OAC, likely be ... Full text Link to item CiteRecent Grants
Myovascular Mechanisms of Cardiac Growth and Regeneration
ResearchCollaborator · Awarded by National Heart, Lung, and Blood Institute · 2022 - 2026Discovery of Novel Rare Variants as Ovarian Cancer Susceptibility Factors
ResearchCo Investigator · Awarded by MD Anderson Cancer Center · 2016 - 2022MAYO Clinic Breast Cancer SPORE-Project 1: Cancer risks for mutations in breast cancer predisposition genes
ResearchPrincipal Investigator · Awarded by Mayo Clinic · 2005 - 2021View All Grants
Education, Training & Certifications
Yale University ·
1995
Ph.D.
The University of Chicago ·
1989
M.S.
The University of Chicago ·
1987
B.S.