Jeffrey Nicholas Browndyke

Jeffrey Nicholas Browndyke
Associate Professor of Psychiatry and Behavioral Sciences

Dr. Browndyke is an Associate Professor of Behavioral Health & Neurosciences in the Department of Psychiatry & Behavioral Sciences. He has a secondary appointment as Assistant Professor of Cardiovascular & Thoracic Surgery.

Dr. Browndyke's research interests involve the use of advanced neurocognitive and neuroimaging techniques for perioperative contributions to delirium and later dementia risk, monitoring of late-life neuropathological disease progression, and intervention/treatment outcomes. His research also involves novel telehealth methods for remote neurocognitive evaluation and implementation of non-invasive neuromodulatory techniques to assist in postoperative recovery and dementia risk reduction.

Dr. Browndyke's clinical expertise is focused upon geriatric neuropsychology with an emphasis in the assessment, diagnosis, and treatment of dementia and related disorders in adults and US veteran patient populations.

Current Appointments & Affiliations

Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Geriatric Behavioral Health, Psychiatry & Behavioral Sciences 2018
Assistant Professor in Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2019
Affiliate of the Center for Brain Imaging and Analysis, Duke-UNC Center for Brain Imaging and Analysis, Institutes and Centers 2007
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2008
Senior Fellow of the Center for the Study of Aging and Human Development, Center for the Study of Aging and Human Development, Institutes and Centers 2020

Contact Information

Durham VA Box 116-A, 508 Fulton St, Durham, NC 27705
Durham VA Box 116-A, 508 Fulton St, Durham, NC 27710
j.browndyke@duke.edu (919) 286-0411

Background
Education, Training, & Certifications
- Psychology Fellowship Program, Psychology, Brown University, Warren Alpert Medical School 2000 - 2003
- Ph.D., Louisiana State University, Baton Rouge 2001
- B.S., The University of Memphis 1993
Recognition
In the News
- APR 17, 2020 U.S. News & World Report
  
  Can Yoga Improve Memory?
- OCT 19, 2019 Anesthesiology Journal
  
  ASA Podcast - Postoperative Delirium and Postoperative Cognitive Dysfunction
- JUL 16, 2018 North Carolina Health News
  
  Focus on Postoperative Decline Could Help NC Patients, Hospitals
- NOV 1, 2017 Society for Neuroscience in Anesthesiology and Critical Care
  
  Experts' Audio Corner - Functional Neuroimaging Correlates of Postoperative Cognitive Dysfunction
- OCT 27, 2015 Duke Anesthesiology
  
  Jeff Browndyke, PhD, Wins Best Abstract
- NOV 19, 2010 WRAL TV
  
  Alzheimer's Disease Gene Expression in Brains of Young Adults
- SEP 11, 2009 U.S. News & World Report
  
  Alzheimer's Gene Affects Brains of Young Adults
Expertise
Subject Headings
Research
Selected Grants
- Using network-guided TMS to ameliorate memory deficits in early Alzheimer's disease awarded by National Institutes of Health 2020 - 2022
- Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health 2017 - 2022
- A Phase II Study of an ApoE mimetic peptide to reduce Postoperative Delirium, Cognitive Dysfunction after Non-Cardiac Surgery in Older Adults awarded by Alzheimer's Drug Discovery Foundation 2018 - 2021
- Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest awarded by National Institutes of Health 2016 - 2021
- Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine-Consortium Agreement awarded by Mount Sinai School of Medicine 2013 - 2021
- The Role of Obstructive Sleep Apnea in Neuroinflammation and Postoperative Cognitive Dysfunction awarded by Foundation for Anesthesia Education and Research 2019 - 2021
- Facility and Web-based Approaches to Lifestyle Change in Resistant Hypertension awarded by National Institutes of Health 2014 - 2020
- Assessing Large-scale Brain Connectivities in Mild Cognitive Impairment awarded by University of Georgia 2013 - 2020
- The Significance of Perioperative Changes in CSF tau levels in the Elderly awarded by National Institutes of Health 2015 - 2018
- Lifestyle, CVD Risk and Cognitive Impairment awarded by National Institutes of Health 2011 - 2018
- The trajectory and significance of perioperative changes in AD biomarkers awarded by International Anesthesia Research Society 2014 - 2018
- Functional connectivity changes in attention networks after cardiac surgery awarded by National Institutes of Health 2012 - 2015
- Relational Memory and Aging: Role of Prefrontal and Medial Temporal Lobe Regions awarded by National Institutes of Health 2005 - 2010
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Terrando, Niccolò, John J. Park, Michael Devinney, Cliburn Chan, Mary Cooter, Pallavi Avasarala, Joseph P. Mathew, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.” Sci Rep 11, no. 1 (February 4, 2021): 3047. https://doi.org/10.1038/s41598-021-82606-5.
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  - Berger, Miles, Mary Cooter, Alexander S. Roesler, Stacey Chung, John Park, Jennifer L. Modliszewski, Keith W. VanDusen, et al. “APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid.” J Alzheimers Dis 79, no. 2 (2021): 511–30. https://doi.org/10.3233/JAD-200747.
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  - Oyeyemi, Deborah M., Mary Cooter, Stacey Chung, Heather E. Whitson, Jeffrey N. Browndyke, Michael J. Devinney, Patrick J. Smith, et al. “Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults.” J Geriatr Psychiatry Neurol, December 30, 2020, 891988720978791. https://doi.org/10.1177/0891988720978791.
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  - Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol 267, no. 7 (July 2020): 2002–6. https://doi.org/10.1007/s00415-020-09797-1.
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  - Ferket, Bart S., Vinod H. Thourani, Pierre Voisine, Samuel F. Hohmann, Helena L. Chang, Peter K. Smith, Robert E. Michler, et al. “Cost-effectiveness of coronary artery bypass grafting plus mitral valve repair versus coronary artery bypass grafting alone for moderate ischemic mitral regurgitation.” J Thorac Cardiovasc Surg 159, no. 6 (June 2020): 2230-2240.e15. https://doi.org/10.1016/j.jtcvs.2019.06.040.
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  - Lala, Anuradha, Helena L. Chang, Xiaoyu Liu, Eric J. Charles, Babatunde A. Yerokun, Michael E. Bowdish, Vinod H. Thourani, et al. “Risk for non-home discharge following surgery for ischemic mitral valve disease.” J Thorac Cardiovasc Surg, March 4, 2020. https://doi.org/10.1016/j.jtcvs.2020.02.084.
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  - Blumenthal, James A., Patrick J. Smith, Stephanie Mabe, Alan Hinderliter, Kathleen Welsh-Bohmer, Jeffrey N. Browndyke, P Murali Doraiswamy, et al. “Longer Term Effects of Diet and Exercise on Neurocognition: 1-Year Follow-up of the ENLIGHTEN Trial.” J Am Geriatr Soc 68, no. 3 (March 2020): 559–68. https://doi.org/10.1111/jgs.16252.
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  - Smith, Patrick J., Stephanie M. Mabe, Andrew Sherwood, P Murali Doraiswamy, Kathleen A. Welsh-Bohmer, James R. Burke, William E. Kraus, et al. “Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.” J Alzheimers Dis 77, no. 4 (2020): 1793–1803. https://doi.org/10.3233/JAD-200374.
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  - VanDusen, Keith W., Sarada Eleswarpu, Eugene W. Moretti, Michael J. Devinney, Donna M. Crabtree, Daniel T. Laskowitz, Marty G. Woldorff, et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.” J Alzheimers Dis 75, no. 4 (2020): 1319–28. https://doi.org/10.3233/JAD-191185.
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  - Madden, David J., M Stephen Melton, Shivangi Jain, Angela D. Cook, Jeffrey N. Browndyke, Todd B. Harshbarger, and Linda C. Cendales. “Neural activation for actual and imagined movement following unilateral hand transplantation: a case study.” Neurocase 25, no. 6 (December 2019): 225–34. https://doi.org/10.1080/13554794.2019.1667398.
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  - Mahanna-Gabrielli, Elizabeth, Katie J. Schenning, Lars I. Eriksson, Jeffrey N. Browndyke, Clinton B. Wright, Deborah J. Culley, Lis Evered, et al. “Corrigendum to 'State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018' (Br J Anaesth 2019; 123: 464-478).” Br J Anaesth 123, no. 6 (December 2019): 917. https://doi.org/10.1016/j.bja.2019.09.014.
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  - Berger, Miles, David M. Murdoch, Janet S. Staats, Cliburn Chan, Jake P. Thomas, Grant E. Garrigues, Jeffrey N. Browndyke, et al. “Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.” Anesth Analg 129, no. 5 (November 2019): e150–54. https://doi.org/10.1213/ANE.0000000000004179.
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  - Mahanna-Gabrielli, Elizabeth, Katie J. Schenning, Lars I. Eriksson, Jeffrey N. Browndyke, Clinton B. Wright, Deborah J. Culley, Lis Evered, et al. “State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018.” Br J Anaesth 123, no. 4 (October 2019): 464–78. https://doi.org/10.1016/j.bja.2019.07.004.
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  - Browndyke, Jeffrey N., Michael Devinney, and Joseph P. Mathew. “The Devil Is in the Details: Comparison of Postoperative Delirium and Neurocognitive Dysfunction.” Anesthesiology 131, no. 3 (September 2019): 456–58. https://doi.org/10.1097/ALN.0000000000002823.
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  - Klinger, Rebecca Y., Mary Cooter, Tiffany Bisanar, Niccolò Terrando, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcomes Research Group of the Duke Heart Center. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.” Anesthesiology 130, no. 6 (June 2019): 958–70. https://doi.org/10.1097/ALN.0000000000002668.
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  - Berger, Miles, Deborah Oyeyemi, Mobolaji O. Olurinde, Heather E. Whitson, Kent J. Weinhold, Marty G. Woldorff, Lewis A. Lipsitz, et al. “The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.” J Am Geriatr Soc 67, no. 4 (April 2019): 794–98. https://doi.org/10.1111/jgs.15770.
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  - Blumenthal, James A., Patrick J. Smith, Stephanie Mabe, Alan Hinderliter, Pao-Hwa Lin, Lawrence Liao, Kathleen A. Welsh-Bohmer, et al. “Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial.” Neurology 92, no. 3 (January 15, 2019): e212–23. https://doi.org/10.1212/WNL.0000000000006784.
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  - Smith, Patrick J., Jeffrey N. Browndyke, Zachary A. Monge, Todd B. Harshbarger, Michael L. James, Jeffrey G. Gaca, John H. Alexander, et al. “Longitudinal Changes in Regional Cerebral Perfusion and Cognition After Cardiac Operation.” Ann Thorac Surg 107, no. 1 (January 2019): 112–18. https://doi.org/10.1016/j.athoracsur.2018.07.056.
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  - Evered, L., B. Silbert, D. S. Knopman, D. A. Scott, S. T. DeKosky, L. S. Rasmussen, E. S. Oh, et al. “Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.” Br J Anaesth 121, no. 5 (November 2018): 1005–12. https://doi.org/10.1016/j.bja.2017.11.087.
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  - Evered, L., B. Silbert, D. S. Knopman, D. A. Scott, S. T. DeKosky, L. S. Rasmussen, E. S. Oh, et al. “Recommendations for the Nomenclature of Cognitive Change Associated With Anaesthesia and Surgery-2018.” Anesth Analg 127, no. 5 (November 2018): 1189–95. https://doi.org/10.1213/ANE.0000000000003634.
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  - Berger, Miles, Niccolò Terrando, S Kendall Smith, Jeffrey N. Browndyke, Mark F. Newman, and Joseph P. Mathew. “Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms.” Anesthesiology 129, no. 4 (October 2018): 829–51. https://doi.org/10.1097/ALN.0000000000002194.
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  - Lansky, Alexandra J., Steven R. Messé, Adam M. Brickman, Michael Dwyer, H. Bart van der Worp, Ronald M. Lazar, Cody G. Pietras, et al. “Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative.” Eur Heart J 39, no. 19 (May 14, 2018): 1687–97. https://doi.org/10.1093/eurheartj/ehx037.
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  - Klinger, Rebecca Y., Olga G. James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, et al. “18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.” Anesthesiology 128, no. 4 (April 2018): 728–44. https://doi.org/10.1097/ALN.0000000000002103.
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  - Browndyke, Jeffrey N., and Mitchell T. Heflin. “Cognition and brain changes associated with high-dose atorvastatin: A BOLD proposition?” Am Heart J 197 (March 2018): 163–65. https://doi.org/10.1016/j.ahj.2017.12.003.
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  - Skrobot, Olivia A., Sandra E. Black, Christopher Chen, Charles DeCarli, Timo Erkinjuntti, Gary A. Ford, Rajesh N. Kalaria, et al. “Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study.” Alzheimers Dement 14, no. 3 (March 2018): 280–92. https://doi.org/10.1016/j.jalz.2017.09.007.
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  - Zietlow, Kahli, Shelley R. McDonald, Richard Sloane, Jeffrey Browndyke, Sandhya Lagoo-Deenadayalan, and Mitchell T. Heflin. “Preoperative Cognitive Impairment As a Predictor of Postoperative Outcomes in a Collaborative Care Model.” J Am Geriatr Soc 66, no. 3 (March 2018): 584–89. https://doi.org/10.1111/jgs.15261.
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  - Browndyke, Jeffrey N., Miles Berger, Patrick J. Smith, Todd B. Harshbarger, Zachary A. Monge, Viral Panchal, Tiffany L. Bisanar, et al. “Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults.” Hum Brain Mapp 39, no. 2 (February 2018): 985–1003. https://doi.org/10.1002/hbm.23898.
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  - Mack, Michael J., Michael A. Acker, Annetine C. Gelijns, Jessica R. Overbey, Michael K. Parides, Jeffrey N. Browndyke, Mark A. Groh, et al. “Effect of Cerebral Embolic Protection Devices on CNS Infarction in Surgical Aortic Valve Replacement: A Randomized Clinical Trial.” Jama 318, no. 6 (August 8, 2017): 536–47. https://doi.org/10.1001/jama.2017.9479.
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  - Skrobot, Olivia A., John O’Brien, Sandra Black, Christopher Chen, Charles DeCarli, Timo Erkinjuntti, Gary A. Ford, et al. “The Vascular Impairment of Cognition Classification Consensus Study.” Alzheimers Dement 13, no. 6 (June 2017): 624–33. https://doi.org/10.1016/j.jalz.2016.10.007.
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  - Lansky, Alexandra J., Steven R. Messé, Adam M. Brickman, Michael Dwyer, H Bart van der Worp, Ronald M. Lazar, Cody G. Pietras, et al. “Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative.” J Am Coll Cardiol 69, no. 6 (February 14, 2017): 679–91. https://doi.org/10.1016/j.jacc.2016.11.045.
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  - Browndyke, Jeffrey N., Miles Berger, Todd B. Harshbarger, Patrick J. Smith, William White, Tiffany L. Bisanar, John H. Alexander, et al. “Resting-State Functional Connectivity and Cognition After Major Cardiac Surgery in Older Adults without Preoperative Cognitive Impairment: Preliminary Findings.” J Am Geriatr Soc 65, no. 1 (January 2017): e6–12. https://doi.org/10.1111/jgs.14534.
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  - Giattino, Charles M., Jacob E. Gardner, Faris M. Sbahi, Kenneth C. Roberts, Mary Cooter, Eugene Moretti, Jeffrey N. Browndyke, et al. “Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.” Front Syst Neurosci 11 (2017): 24. https://doi.org/10.3389/fnsys.2017.00024.
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  - Melton, M Stephen, Jeffrey N. Browndyke, Todd B. Harshbarger, David J. Madden, Karen C. Nielsen, and Stephen M. Klein. “Changes in Brain Resting-state Functional Connectivity Associated with Peripheral Nerve Block: A Pilot Study.” Anesthesiology 125, no. 2 (August 2016): 368–77. https://doi.org/10.1097/ALN.0000000000001198.
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  - Gillinov, A Marc, Emilia Bagiella, Alan J. Moskowitz, Jesse M. Raiten, Mark A. Groh, Michael E. Bowdish, Gorav Ailawadi, et al. “Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery.” N Engl J Med 374, no. 20 (May 19, 2016): 1911–21. https://doi.org/10.1056/NEJMoa1602002.
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  - Michler, Robert E., Peter K. Smith, Michael K. Parides, Gorav Ailawadi, Vinod Thourani, Alan J. Moskowitz, Michael A. Acker, et al. “Two-Year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation.” N Engl J Med 374, no. 20 (May 19, 2016): 1932–41. https://doi.org/10.1056/NEJMoa1602003.
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  - Greco, Giampaolo, Bart S. Ferket, David A. D’Alessandro, Wei Shi, Keith A. Horvath, Alexander Rosen, Stacey Welsh, et al. “Diabetes and the Association of Postoperative Hyperglycemia With Clinical and Economic Outcomes in Cardiac Surgery.” Diabetes Care 39, no. 3 (March 2016): 408–17. https://doi.org/10.2337/dc15-1817.
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  - Goldstein, Daniel, Alan J. Moskowitz, Annetine C. Gelijns, Gorav Ailawadi, Michael K. Parides, Louis P. Perrault, Judy W. Hung, et al. “Two-Year Outcomes of Surgical Treatment of Severe Ischemic Mitral Regurgitation.” N Engl J Med 374, no. 4 (January 28, 2016): 344–53. https://doi.org/10.1056/NEJMoa1512913.
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  - Foster, Chris M., Donna Rose Addis, Jaclyn H. Ford, Daniel I. Kaufer, James R. Burke, Jeffrey N. Browndyke, Kathleen A. Welsh-Bohmer, and Kelly S. Giovanello. “Prefrontal contributions to relational encoding in amnestic mild cognitive impairment.” Neuroimage Clin 11 (2016): 158–66. https://doi.org/10.1016/j.nicl.2016.01.008.
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  - Berger, Miles, Jacob W. Nadler, Jeffrey Browndyke, Niccolo Terrando, Vikram Ponnusamy, Harvey Jay Cohen, Heather E. Whitson, and Joseph P. Mathew. “Postoperative Cognitive Dysfunction: Minding the Gaps in Our Knowledge of a Common Postoperative Complication in the Elderly.” Anesthesiol Clin 33, no. 3 (September 2015): 517–50. https://doi.org/10.1016/j.anclin.2015.05.008.
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  - Berger, Miles, Jeffrey Browndyke, and Joseph P. Mathew. “Intraoperative Glycemic Control to Prevent Delirium after Cardiac Surgery: Steering a Course between Scylla and Charybdis.” Anesthesiology 122, no. 6 (June 2015): 1186–88. https://doi.org/10.1097/ALN.0000000000000670.
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  - Kron, Irving L., Judy Hung, Jessica R. Overbey, Denis Bouchard, Annetine C. Gelijns, Alan J. Moskowitz, Pierre Voisine, et al. “Predicting recurrent mitral regurgitation after mitral valve repair for severe ischemic mitral regurgitation.” J Thorac Cardiovasc Surg 149, no. 3 (March 2015): 752-61.e1. https://doi.org/10.1016/j.jtcvs.2014.10.120.
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  - Smith, Peter K., John D. Puskas, Deborah D. Ascheim, Pierre Voisine, Annetine C. Gelijns, Alan J. Moskowitz, Judy W. Hung, et al. “Surgical treatment of moderate ischemic mitral regurgitation.” N Engl J Med 371, no. 23 (December 4, 2014): 2178–88. https://doi.org/10.1056/NEJMoa1410490.
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  - Hayden, Kathleen M., Maragatha Kuchibhatla, Heather R. Romero, Brenda L. Plassman, James R. Burke, Jeffrey N. Browndyke, and Kathleen A. Welsh-Bohmer. “Pre-clinical cognitive phenotypes for Alzheimer disease: a latent profile approach.” The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry 22, no. 11 (November 2014): 1364–74. https://doi.org/10.1016/j.jagp.2013.07.008.
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  - Browndyke, Jeffrey N., and Joseph P. Mathew. “Neurological injury after transcatheter aortic valve implantation: are the trees falling silently or is our hearing impaired?” Circ Cardiovasc Interv 6, no. 6 (December 2013): 599–601. https://doi.org/10.1161/CIRCINTERVENTIONS.113.001017.
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  - Mathew, Joseph P., William D. White, David B. Schinderle, Mihai V. Podgoreanu, Miles Berger, Carmelo A. Milano, Daniel T. Laskowitz, et al. “Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery.” Stroke 44, no. 12 (December 2013): 3407–13. https://doi.org/10.1161/STROKEAHA.113.002703.
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  - Browndyke, Jeffrey N., Kelly Giovanello, Jeffrey Petrella, Kathleen Hayden, Ornit Chiba-Falek, Karen A. Tucker, James R. Burke, and Kathleen A. Welsh-Bohmer. “Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease.” Alzheimers Dement 9, no. 3 (May 2013): 284–94. https://doi.org/10.1016/j.jalz.2011.12.006.
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  - Fontes, Monique T., R Cameron Swift, Barbara Phillips-Bute, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcome Research Group of the Duke Heart Center. “Predictors of cognitive recovery after cardiac surgery.” Anesth Analg 116, no. 2 (February 2013): 435–42. https://doi.org/10.1213/ANE.0b013e318273f37e.
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  - Blumenthal, James A., Patrick J. Smith, Kathleen Welsh-Bohmer, Michael A. Babyak, Jeffrey Browndyke, Pao-Hwa Lin, P Murali Doraiswamy, et al. “Can lifestyle modification improve neurocognition? Rationale and design of the ENLIGHTEN clinical trial.” Contemp Clin Trials 34, no. 1 (January 2013): 60–69. https://doi.org/10.1016/j.cct.2012.09.004.
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  - Giovanello, Kelly S., Felipe De Brigard, Jaclyn Hennessey Ford, Daniel I. Kaufer, James R. Burke, Jeffrey N. Browndyke, and Kathleen A. Welsh-Bohmer. “Event-related functional magnetic resonance imaging changes during relational retrieval in normal aging and amnestic mild cognitive impairment.” Journal of the International Neuropsychological Society : Jins 18, no. 5 (September 2012): 886–97. https://doi.org/10.1017/s1355617712000689.
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  - Wee, Chong-Yaw, Pew-Thian Yap, Daoqiang Zhang, Kevin Denny, Jeffrey N. Browndyke, Guy G. Potter, Kathleen A. Welsh-Bohmer, Lihong Wang, and Dinggang Shen. “Identification of MCI individuals using structural and functional connectivity networks.” Neuroimage 59, no. 3 (February 1, 2012): 2045–56. https://doi.org/10.1016/j.neuroimage.2011.10.015.
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  - Wee, Chong-Yaw, Pew-Thian Yap, Kevin Denny, Jeffrey N. Browndyke, Guy G. Potter, Kathleen A. Welsh-Bohmer, Lihong Wang, and Dinggang Shen. “Resting-state multi-spectrum functional connectivity networks for identification of MCI patients.” Plos One 7, no. 5 (2012): e37828. https://doi.org/10.1371/journal.pone.0037828.
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  - Hayden, Kathleen M., Richard N. Jones, Catherine Zimmer, Brenda L. Plassman, Jeffrey N. Browndyke, Carl Pieper, Lauren H. Warren, and Kathleen A. Welsh-Bohmer. “Factor structure of the National Alzheimer's Coordinating Centers uniform dataset neuropsychological battery: an evaluation of invariance between and within groups over time.” Alzheimer Dis Assoc Disord 25, no. 2 (April 2011): 128–37. https://doi.org/10.1097/WAD.0b013e3181ffa76d.
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  - Tosun, Duygu, Norbert Schuff, Chester A. Mathis, William Jagust, Michael W. Weiner, and Michael W. Alzheimer’s Disease NeuroImaging Initiative. “Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment.” Brain 134, no. Pt 4 (April 2011): 1077–88. https://doi.org/10.1093/brain/awr044.
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  - Kauwe, John S. K., Carlos Cruchaga, Celeste M. Karch, Brooke Sadler, Mo Lee, Kevin Mayo, Wayne Latu, et al. “Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.” Plos One 6, no. 2 (February 9, 2011): e15918. https://doi.org/10.1371/journal.pone.0015918.
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  - Wee, Chong-Yaw, Pew-Thian Yap, Wenbin Li, Kevin Denny, Jeffrey N. Browndyke, Guy G. Potter, Kathleen A. Welsh-Bohmer, Lihong Wang, and Dinggang Shen. “Enriched white matter connectivity networks for accurate identification of MCI patients.” Neuroimage 54, no. 3 (February 1, 2011): 1812–22. https://doi.org/10.1016/j.neuroimage.2010.10.026.
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  - Carmichael, Owen, Christopher Schwarz, David Drucker, Evan Fletcher, Danielle Harvey, Laurel Beckett, Clifford R. Jack, Michael Weiner, Charles DeCarli, and Charles Alzheimer’s Disease Neuroimaging Initiative. “Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative.” Arch Neurol 67, no. 11 (November 2010): 1370–78. https://doi.org/10.1001/archneurol.2010.284.
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  - Wee, C. Y., P. T. Yap, J. N. Brownyke, G. G. Potter, D. C. Steffens, K. Welsh-Bohmer, L. Wang, and D. Shen. “Accurate identification of MCI patients via enriched white-matter connectivity network.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 6357 LNCS (October 25, 2010): 140–47. https://doi.org/10.1007/978-3-642-15948-0_18.
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  - Dennis, Nancy A., Jeffrey N. Browndyke, Jared Stokes, Anna Need, James R. Burke, Kathleen A. Welsh-Bohmer, and Roberto Cabeza. “Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers.” Alzheimers Dement 6, no. 4 (July 2010): 303–11. https://doi.org/10.1016/j.jalz.2009.07.003.
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  - Hill, B. D., Charles A. Barkemeyer, Glenn N. Jones, Michael P. Santa Maria, Kyle S. Minor, and Jeffrey N. Browndyke. “Validation of the coin rotation test: a simple, inexpensive, and convenient screening tool for impaired psychomotor processing speed.” Neurologist 16, no. 4 (July 2010): 249–53. https://doi.org/10.1097/NRL.0b013e3181b1d5b0.
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  - Smith, Patrick J., James A. Blumenthal, Michael A. Babyak, Linda Craighead, Kathleen A. Welsh-Bohmer, Jeffrey N. Browndyke, Timothy A. Strauman, and Andrew Sherwood. “Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure.” Hypertension 55, no. 6 (June 2010): 1331–38. https://doi.org/10.1161/HYPERTENSIONAHA.109.146795.
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  - Smith, Patrick J., James A. Blumenthal, Benson M. Hoffman, Harris Cooper, Timothy A. Strauman, Kathleen Welsh-Bohmer, Jeffrey N. Browndyke, and Andrew Sherwood. “Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials.” Psychosom Med 72, no. 3 (April 2010): 239–52. https://doi.org/10.1097/PSY.0b013e3181d14633.
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  - Romero, H. R., J. N. Browndyke, J. R. Burke, K. M. Hayden, and K. A. Welsh-Bohmer. “Executive Measures are Related to Functional Ability in an Ethnically Diverse Cohort.” Clinical Neuropsychologist 24, no. 4 (January 1, 2010): 599–600.
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  - Linnertz, Colton, Laura Saucier, Dongliang Ge, Kenneth D. Cronin, James R. Burke, Jeffrey N. Browndyke, Christine M. Hulette, Kathleen A. Welsh-Bohmer, and Ornit Chiba-Falek. “Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues.” Plos One 4, no. 10 (October 16, 2009): e7480. https://doi.org/10.1371/journal.pone.0007480.
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  - Browndyke, Jeffrey N., James Paskavitz, Lawrence H. Sweet, Ronald A. Cohen, Karen A. Tucker, Kathleen A. Welsh-Bohmer, James R. Burke, and Donald E. Schmechel. “Neuroanatomical correlates of malingered memory impairment: event-related fMRI of deception on a recognition memory task.” Brain Inj 22, no. 6 (June 2008): 481–89. https://doi.org/10.1080/02699050802084894.
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  - Schmechel, Donald E., Jeffrey Browndyke, and Andrew Ghio. “Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders.” Neurotoxicology 27, no. 5 (September 2006): 637–57. https://doi.org/10.1016/j.neuro.2006.05.021.
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  - Akomolafe, A., K. L. Lunetta, P. M. Erlich, L. A. Cupples, C. T. Baldwin, M. Huyck, R. C. Green, L. A. Farrer, and L. A. MIRAGE Study Group. “Genetic association between endothelial nitric oxide synthase and Alzheimer disease.” Clin Genet 70, no. 1 (July 2006): 49–56. https://doi.org/10.1111/j.1399-0004.2006.00638.x.
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  - Erlich, Porat M., Kathryn L. Lunetta, L Adrienne Cupples, Matthew Huyck, Robert C. Green, Clinton T. Baldwin, Lindsay A. Farrer, and Lindsay A. MIRAGE Study Group. “Polymorphisms in the PON gene cluster are associated with Alzheimer disease.” Hum Mol Genet 15, no. 1 (January 1, 2006): 77–85. https://doi.org/10.1093/hmg/ddi428.
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  - Sweet, Lawrence H., James F. Paskavitz, Matthew J. O’Connor, Jeffrey N. Browndyke, Jeremy W. Wellen, and Ronald A. Cohen. “FMRI correlates of the WAIS-III symbol search subtest.” J Int Neuropsychol Soc 11, no. 4 (July 2005): 471–76. https://doi.org/10.1017/s1355617705050575.
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  - Gunstad, John, Adam M. Brickman, Robert H. Paul, Jeffrey Browndyke, David J. Moser, Brian R. Ott, Norman Gordon, Omar Haque, and Ronald A. Cohen. “Progressive morphometric and cognitive changes in vascular dementia.” Arch Clin Neuropsychol 20, no. 2 (March 2005): 229–41. https://doi.org/10.1016/j.acn.2004.07.001.
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  - Browndyke, J. N. “Ethical challenges with the use of information technology and telecommunications in neuropsychology, Part I,” November 11, 2004, 195–207. https://doi.org/10.4324/9780203025505.
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  - Tucker, Karen A., Marc N. Potenza, John E. Beauvais, Jeffrey N. Browndyke, P Christopher Gottschalk, and Thomas R. Kosten. “Perfusion abnormalities and decision making in cocaine dependence.” Biol Psychiatry 56, no. 7 (October 1, 2004): 527–30. https://doi.org/10.1016/j.biopsych.2004.06.031.
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  - Garrett, Kelly Davis, Jeffrey N. Browndyke, William Whelihan, Robert H. Paul, Margaret DiCarlo, David J. Moser, Ronald A. Cohen, and Brian R. Ott. “The neuropsychological profile of vascular cognitive impairment--no dementia: comparisons to patients at risk for cerebrovascular disease and vascular dementia.” Arch Clin Neuropsychol 19, no. 6 (September 2004): 745–57. https://doi.org/10.1016/j.acn.2003.09.008.
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  - Gouvier, W. D., J. B. Pinkston, J. C. Lovejoy, S. R. Smith, G. A. Bray, M. P. Santa Maria, J. H. Hammer, et al. “Erratum: Neuropsychological and emotional changes during simulated microgravity: Effects of triiodothyronine, alendronate, and testosterone (Archives of Clinical Neuropsychology (2004) 19 (153-163) DOI: 10.1016/j.acn.2002.09.001).” Archives of Clinical Neuropsychology 19, no. 4 (June 1, 2004): 595. https://doi.org/10.1016/S0887-6177(04)00075-7.
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  - Tucker, Karen A., Jeffrey N. Browndyke, P Christopher Gottschalk, Anthony T. Cofrancesco, and Thomas R. Kosten. “Gender-specific vulnerability for rCBF abnormalities among cocaine abusers.” Neuroreport 15, no. 5 (April 9, 2004): 797–801. https://doi.org/10.1097/00001756-200404090-00011.
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  - Browndyke, Jeffrey N., Karen A. Tucker, Steven P. Woods, John Beauvals, Ronald A. Cohen, P. C. Gottschalk, and Thomas R. Kosten. “Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers.” J Neuroimaging 14, no. 2 (April 2004): 162–69.
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  - Gouvier, Wm Drew, James B. Pinkston, Jennifer C. Lovejoy, Steven R. Smith, George A. Bray, Michael P. Santa Maria, Jill Hayes Hammer, et al. “Neuropsychological and emotional changes during simulated microgravity: effects of triiodothyronine alendronate, and testosterone.” Arch Clin Neuropsychol 19, no. 2 (March 2004): 153–63. https://doi.org/10.1016/j.acn.2002.09.001.
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  - Sweet, Lawrence H., Robert H. Paul, Ronald A. Cohen, David Moser, Brian R. Ott, Norman Gordon, Jeff N. Browndyke, Pari Shah, and Kelly D. Garrett. “Neuroimaging correlates of dementia rating scale performance at baseline and 12-month follow-up among patients with vascular dementia.” J Geriatr Psychiatry Neurol 16, no. 4 (December 2003): 240–44. https://doi.org/10.1177/0891988703258322.
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  - Paul, Robert H., Ronald A. Cohen, David J. Moser, Brian R. Ott, Manish Sethi, Lawrence Sweet, Jeff Browndyke, Paul Malloy, and Kelly Garrett. “Clinical correlates of cognitive decline in vascular dementia.” Cogn Behav Neurol 16, no. 1 (March 2003): 40–46. https://doi.org/10.1097/00146965-200303000-00005.
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  - Cohen, Ronald A., Jeffrey N. Browndyke, David J. Moser, Robert H. Paul, Norman Gordon, and Lawrence Sweet. “Long-term citicoline (cytidine diphosphate choline) use in patients with vascular dementia: neuroimaging and neuropsychological outcomes.” Cerebrovasc Dis 16, no. 3 (2003): 199–204. https://doi.org/10.1159/000071116.
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  - Paul, Robert H., Ronald A. Cohen, David J. Moser, Jeff N. Browndyke, Kelly Davis, Norman Gordon, Lawrence Sweet, Jeffrey J. Lawrence, and Tricia Zawacki. “Sensitivity of the dementia rating scale in vascular dementia: comparison between two sets of criteria to define cognitive impairment.” Cerebrovasc Dis 15, no. 1–2 (2003): 116–20. https://doi.org/10.1159/000067138.
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  - Browndyke, Jeffrey N., David J. Moser, Ronald A. Cohen, Daniel J. O’Brien, James J. Algina, William G. Haynes, Edward D. Staples, James Alexander, Laurie K. Davies, and Russell M. Bauer. “Acute neuropsychological functioning following cardiosurgical interventions associated with the production of intraoperative cerebral microemboli.” Clin Neuropsychol 16, no. 4 (December 2002): 463–71. https://doi.org/10.1076/clin.16.4.463.13910.
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  - Browndyke, J. N., K. A. Tucker, L. H. Sweet, R. H. Paul, and R. A. Cohen. “The effects of gender and time on regional cortical perfusion in vascular dementia patients.” Archives of Clinical Neuropsychology 17, no. 8 (November 1, 2002): 747–747.
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  - Sweet, L. H., R. H. Paul, J. N. Browndyke, and R. A. Cohen. “Neuroimaging correlates of Dementia Rating Scale performance at baseline and 12-month followup among patients with vascular dementia.” Archives of Clinical Neuropsychology 17, no. 8 (November 1, 2002): 762–762.
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  - Tucker, K. A., J. N. Browndyke, W. D. Gouvier, J. Beauvais, C. Gottschalk, and T. Kosten. “Examination of the relative contribution of cocaine and alcohol to neuropsychological functioning.” Archives of Clinical Neuropsychology 17, no. 8 (November 1, 2002): 814–814.
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  - Schatz, Philip, and Jeffrey Browndyke. “Applications of computer-based neuropsychological assessment.” J Head Trauma Rehabil 17, no. 5 (October 2002): 395–410. https://doi.org/10.1097/00001199-200210000-00003.
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  - Browndyke, Jeffrey N., Ashlie L. Albert, William Malone, Phillip Schatz, Robert H. Paul, Ronald A. Cohen, Karen A. Tucker, and W Drew Gouvier. “Computer-related anxiety: examining the impact of technology-specific affect on the performance of a computerized neuropsychological assessment measure.” Appl Neuropsychol 9, no. 4 (2002): 210–18. https://doi.org/10.1207/S15324826AN0904_3.
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  - Murero, M., G. D’Ancona, and H. Karamanoukian. “Use of the Internet by patients before and after cardiac surgery: telephone survey.” Journal of Medical Internet Research 3, no. 3 (July 2001): E27. https://doi.org/10.2196/jmir.3.3.e27.
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  - Paul, R., D. Moser, R. Cohen, J. Browndyke, T. Zawacki, and N. Gordon. “Dementia severity and pattern of cognitive performance in vascular dementia.” Appl Neuropsychol 8, no. 4 (2001): 211–17. https://doi.org/10.1207/S15324826AN0804_3.
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  - Pinkston, J. B., W. D. Gouvier, J. N. Browndyke, and P. J. Varnado. “Chronic neuropsychological effects of long-term mercury exposure: A longitudinal study.” Archives of Clinical Neuropsychology 14, no. 8 (November 1, 1999): 659–659. https://doi.org/10.1093/arclin/14.8.659.
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  - Browndyke, J. N., W. D. Gouvier, and W. F. Waters. “Predictors of ANS sympathetic activity and intensity in a large scale MHI population: Online neuropsychology project II.” Archives of Clinical Neuropsychology 14, no. 1 (January 1, 1999): 26–27. https://doi.org/10.1093/arclin/14.1.26.
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  - Schatz, P., and J. Browndyke. “Trends in computer usage and means of obtaining CE credits among professional psychologists.” Archives of Clinical Neuropsychology 14, no. 1 (January 1, 1999): 159–159. https://doi.org/10.1093/arclin/14.1.159.
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  - Barkemeyer, C. “The coin rotation task: A convenient and sensitive measure of fine motor control.” Archives of Clinical Neuropsychology 13, no. 1 (February 1998): 18–18. https://doi.org/10.1016/s0887-6177(98)90379-1.
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  - Browndyke, J. N., M. P. S. Maria, J. B. Pinkston, and W. D. Gouvier. “Online neuropsychology project: A survey of general head injury and prevention knowledge between professionals and non-professionals.” Archives of Clinical Neuropsychology 13, no. 1 (February 1, 1998): 133–133. https://doi.org/10.1093/arclin/13.1.133.
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  - Browndyke, J. N., W. D. Gouvier, W. F. Waters, J. A. Johnson, and L. Russell. “The effects of mild head injury and postconcussive symptomology on the skin conductance orienting response.” Archives of Clinical Neuropsychology 13, no. 1 (February 1, 1998): 132–132. https://doi.org/10.1093/arclin/13.1.132a.
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  - Hilsabeck, R. C., J. N. Browndyke, W. D. Gouvier, and J. Jones. “Convergent and discriminant validity of the memory assessment scales (MAS).” Archives of Clinical Neuropsychology 13, no. 1 (January 1, 1998): 25–26.
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  - Santa Maria, M. P., J. B. Pinkston, J. N. Browndyke, and W. Drew Gouvier. “Fine tuning the graphesthesia assessment: one stroke versus two.” Appl Neuropsychol 4, no. 2 (1997): 127–29. https://doi.org/10.1207/s15324826an0402_5.
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  - Blumenthal, James A., Patrick J. Smith, Stephanie Mabe, Alan Hinderliter, Kathleen Welsh-Bohmer, Jeffrey N. Browndyke, Pao-Hwa Lin, et al. “Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment.” Psychosom Med 79, no. 6 (n.d.): 719–27. https://doi.org/10.1097/PSY.0000000000000474.
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- Conference Papers
  - Devinney, M. J., P. J. Smith, A. R. Spector, Y. Cheong, V. A. Wickenheisser, J. N. Browndyke, M. Cooter, J. P. Mathew, and M. Berger. “The Association of Obstructive Sleep Apnea Risk with Postoperative Cognitive Decline.” In Journal of the American Geriatrics Society, 67:S178–S178. WILEY, 2019.
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  - Heflin, M., J. N. Browndyke, S. Lagoo, N. Loyack, C. Frede, H. Barrett, A. Mathis, M. Yanamadala, and A. Barbeito. “POSH-DREAM: Mobile Point-of-Contact Delirium Risk Assessment & Identification.” In Journal of the American Geriatrics Society, 67:S136–S136. WILEY, 2019.
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  - Oyeyemi, D., H. Whitson, J. N. Browndyke, H. J. Cohen, J. P. Mathew, and M. Berger. “Depression, Anxiety and Postoperative Cognition in Older Adults.” In Journal of the American Geriatrics Society, 67:S338–S338. WILEY, 2019.
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  - Khan, Babar A., Carol Chan, Heidi Lindroth, Jeffrey Browndyke, Jo Ellen Wilson, and Sophia Wang. “DECONSTRUCTING DELIRIUM: RETHINKING THE ROLE OF BIOMARKERS AND DIAGNOSTIC ANOMALIES.” In The American Journal of Geriatric Psychiatry, 27:S38–39. Elsevier BV, 2019. https://doi.org/10.1016/j.jagp.2019.01.188.
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  - Berger, M., J. Browndyke, M. Cooter, W. Bullock, B. Colin, J. Gadsden, E. Iboaya, et al. “Postoperative Changes in CSF AD Markers, Cognition, and fMRI activity.” In Journal of the American Geriatrics Society, 66:S5–S5. WILEY, 2018.
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  - Piccini, Jonathan P., Jeffrey Browndyke, Mary Cooter, Tiffany Bisanar, Ashley Flynn, Marat Fudim, Nathan H. Waldron, Mark F. Newman, James P. Daubert, and Joseph P. Mathew. “Neurocognitive Function in Atrial Fibrillation: Catheter Ablation versus Medical Management.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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  - Browndyke, Jeffrey N., Sophia Wang, Marie DeWitt, and Malaz Boustani. “COMING TOGETHER TO FIGHT DELIRIUM: HOW TO DELIVER TEAM-BASED, INTERDISCIPLINARY CARE TO PREVENT, DETECT, AND MANAGE DELIRIUM AND ITS LONG-TERM SEQUELAE.” In American Journal of Geriatric Psychiatry, 25:S25–26. ELSEVIER SCIENCE INC, 2017.
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  - Wang, Sophia, Patrick J. Smith, and Jeffrey Browndyke. “Delirium and Post-Operative Cognitive Decline: Who is at Risk for the Long-Term Neurocognitive and Neuropsychiatric Effects?” In The American Journal of Geriatric Psychiatry, 24:S27–S27. Elsevier BV, 2016. https://doi.org/10.1016/j.jagp.2016.01.039.
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  - Kamholz, Barbara, Jeffrey N. Browndyke, and Sophia Wang. “Frailty, Delirium, and Postoperative Cognitive Decline: What Are the Long-Term Effects of Acute Late-Life Medical and Surgical Events?” In The American Journal of Geriatric Psychiatry, 23:S5–6. Elsevier BV, 2015. https://doi.org/10.1016/j.jagp.2014.12.009.
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  - Foster, Chris, Donna Addis, Jaclyn Ford, Daniel Kaufer, Jeffrey Browndyke, Kathleen Welsh-Bohmer, and Kelly Giovanello. “PREFRONTAL CONTRIBUTIONS TO RELATIONAL ENCODING IN HEALTHY AGING AND MILD COGNITIVE IMPAIRMENT.” In Journal of Cognitive Neuroscience, 197–197. MIT PRESS, 2013.
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  - Browndyke, Jeffrey N., Guy G. Potter, and Brenda L. Plassman. “P1-109 Verbal recognition memory differences in Alzheimer's disease and vascular dementia: examining recognition response characteristics independent of dementia severity.” In Neurobiology of Aging, 25:S126–S126. Elsevier BV, 2004. https://doi.org/10.1016/s0197-4580(04)80423-8.
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