Overview
Dr. Browndyke is an Associate Professor of Behavioral Health & Neurosciences in the Department of Psychiatry & Behavioral Sciences. He has a secondary appointment as Assistant Professor of Cardiovascular & Thoracic Surgery.
Dr. Browndyke's research interests involve the use of advanced neurocognitive and neuroimaging techniques for perioperative contributions to delirium and later dementia risk, monitoring of late-life neuropathological disease progression, and intervention/treatment outcomes. His research also involves novel telehealth methods for remote neurocognitive evaluation and implementation of non-invasive neuromodulatory techniques to assist in postoperative recovery and dementia risk reduction.
Dr. Browndyke's clinical expertise is focused upon geriatric neuropsychology with an emphasis in the assessment, diagnosis, and treatment of dementia and related disorders in adults and US veteran patient populations.
Dr. Browndyke's research interests involve the use of advanced neurocognitive and neuroimaging techniques for perioperative contributions to delirium and later dementia risk, monitoring of late-life neuropathological disease progression, and intervention/treatment outcomes. His research also involves novel telehealth methods for remote neurocognitive evaluation and implementation of non-invasive neuromodulatory techniques to assist in postoperative recovery and dementia risk reduction.
Dr. Browndyke's clinical expertise is focused upon geriatric neuropsychology with an emphasis in the assessment, diagnosis, and treatment of dementia and related disorders in adults and US veteran patient populations.
Current Appointments & Affiliations
Associate Professor of Psychiatry and Behavioral Sciences
·
2026 - Present
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences,
Psychiatry & Behavioral Sciences
Assistant Professor in Surgery
·
2020 - Present
Surgery, Cardiovascular and Thoracic Surgery,
Surgery
Affiliate of the Center for Brain Imaging and Analysis
·
2007 - Present
Duke-UNC Brain Imaging and Analysis Center,
Institutes and Centers
Faculty Network Member of the Duke Institute for Brain Sciences
·
2008 - Present
Duke Institute for Brain Sciences,
University Institutes and Centers
Senior Fellow of the Center for the Study of Aging and Human Development
·
2020 - Present
Center for the Study of Aging and Human Development,
Institutes and Centers
Recent Publications
Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients: The Phase 2 MARBLE Randomized Clinical Trial.
Journal Article JAMA Netw Open · April 1, 2026 IMPORTANCE: The apolipoprotein E (APOE) gene ε4 allele leads to increased Alzheimer disease risk and neuroinflammation and is also believed to play a role in postoperative delirium. However, the safety and feasibility of modulating apoE protein signaling t ... Full text Link to item CiteMixed-methods Analysis of Preoperative Distress and Postoperative Outcomes in a Prospective, Observational Cohort of Older Adults.
Journal Article Anesthesiology · January 1, 2026 BACKGROUND: The effect of psychological distress on general geriatric surgery outcomes remains unexplored despite recommendations for routine, preoperative distress screening. This study aimed to assess preoperative distress measures in a general geriatric ... Full text Link to item CiteDeveloping Topics.
Journal Article Alzheimers Dement · December 2025 BACKGROUND: Postoperative delirium (POD), characterized by acute fluctuations in consciousness and attention, is associated with increased risk of Alzheimer's disease and related dementias. However, the neural mechanisms underlying attention impairments in ... Full text Link to item CiteRecent Grants
Neural Mechanisms Underlying Attentional Resilience in the Aging Brain
ResearchCo Investigator · Awarded by National Institute on Aging · 2024 - 2029Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention
ResearchCo Investigator · Awarded by National Institute on Aging · 2022 - 2027Neurocognition & Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)
Clinical TrialCo Investigator · Awarded by National Institute on Aging · 2021 - 2026View All Grants
Education
Louisiana State University, Baton Rouge ·
2001
Ph.D.