Jeffrey Nicholas Browndyke

Jeffrey Nicholas Browndyke
Associate Professor in Psychiatry and Behavioral Sciences

Dr. Browndyke is an Associate Professor of Geriatric Behavioral Health in the Department of Psychiatry & Behavioral Sciences. He also holds affiliate faculty appointments with the Duke Brain Imaging & Analysis Center (BIAC), Duke Institute for Brain Science (DIBS), Center for Cognitive Neuroscience (CCN), and the Duke Center for Geriatric Surgery. He has dual appointment to the Duke University Medical Center and the Durham VA Medical Center, the latter of which is where his clinical work is currently conducted.

Dr. Browndyke's research interests include the development and use of functional and structural neuroimaging biomarkers for perioperative contributions to delirium and later dementia risk, monitoring of late-life neuropathological disease progression, and intervention/treatment outcomes. His research also involves the differential expression of cognitive and behavioral characteristics of late-life postoperative cognitive dysfunction and delirium and their association with later dementia risk.

Dr. Browndyke's clinical expertise is focused upon adult and geriatric populations with an emphasis in the assessment, diagnosis, and treatment of dementia and related disorders, as well as forensic/medicolegal evaluation of adults and US veteran patient populations.

Current Appointments & Affiliations

Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Geriatric Behavioral Health, Psychiatry & Behavioral Sciences 2018
Affiliate of the Center for Brain Imaging and Analysis, Duke-UNC Center for Brain Imaging and Analysis, Institutes and Centers 2007
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2008

Contact Information

Box 3503 Med Ctr, Durham, NC 27710
Durham VAMC - Psychology Servi, 508 Fulton Street, Durham, NC 27705
j.browndyke@duke.edu (336) 264-4222

Background
Education, Training, & Certifications
- Ph.D., Louisiana State University at Baton Rouge 2001
- B.S., University of Memphis 1993
Recognition
In the News
- JUL 16, 2018 North Carolina Health News
  
  Focus on Postoperative Decline Could Help NC Patients, Hospitals
- NOV 1, 2017 Society for Neuroscience in Anesthesiology and Critical Care
  
  Experts' Audio Corner - Functional Neuroimaging Correlates of Postoperative Cognitive Dysfunction
- OCT 27, 2015 Duke Anesthesiology
  
  Jeff Browndyke, PhD, Wins Best Abstract
- NOV 19, 2010 WRAL TV
  
  Alzheimer's Disease Gene Expression in Brains of Young Adults
- SEP 11, 2009 U.S. News & World Report
  
  Alzheimer's Gene Affects Brains of Young Adults
Expertise
Subject Headings
Research
Selected Grants
- Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health 2017 - 2022
- A Phase II Study of an ApoE mimetic peptide to reduce Postoperative Delirium, Cognitive Dysfunction after Non-Cardiac Surgery in Older Adults awarded by Alzheimer's Drug Discovery Foundation 2018 - 2021
- Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest awarded by National Institutes of Health 2016 - 2021
- Assessing Large-scale Brain Connectivities in Mild Cognitive Impairment awarded by University of Georgia 2013 - 2020
- The Role of Obstructive Sleep Apnea in Neuroinflammation and Postoperative Cognitive Dysfunction awarded by Foundation for Anesthesia Education and Research 2019
- Facility and Web-based Approaches to Lifestyle Change in Resistant Hypertension awarded by National Institutes of Health 2014 - 2019
- Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine-Consortium Agreement awarded by Mount Sinai School of Medicine 2013 - 2019
- The Significance of Perioperative Changes in CSF tau levels in the Elderly awarded by National Institutes of Health 2015 - 2018
- Lifestyle, CVD Risk and Cognitive Impairment awarded by National Institutes of Health 2011 - 2018
- The trajectory and significance of perioperative changes in AD biomarkers awarded by International Anesthesia Research Society 2014 - 2018
- Functional connectivity changes in attention networks after cardiac surgery awarded by National Institutes of Health 2012 - 2015
- Relational Memory and Aging: Role of Prefrontal and Medial Temporal Lobe Regions awarded by National Institutes of Health 2005 - 2010
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Berger, M, Oyeyemi, D, Olurinde, MO, Whitson, HE, Weinhold, KJ, Woldorff, MG, Lipsitz, LA, Moretti, E, Giattino, CM, Roberts, KC, Zhou, J, Bunning, T, Ferrandino, M, Scheri, RP, Cooter, M, Chan, C, Cabeza, R, Browndyke, JN, Murdoch, DM, Devinney, MJ, Shaw, LM, Cohen, HJ, Mathew, JP, and INTUIT Investigators, . "The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction." Journal of the American Geriatrics Society 67, no. 4 (April 2019): 794-798. Full Text Open Access Copy
  - Klinger, RY, Cooter, M, Bisanar, T, Terrando, N, Berger, M, Podgoreanu, MV, Stafford-Smith, M, Newman, MF, Mathew, JP, and Neurologic Outcomes Research Group of the Duke Heart Center, . "Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial." Anesthesiology (March 11, 2019). Full Text
  - Blumenthal, JA, Smith, PJ, Mabe, S, Hinderliter, A, Lin, P-H, Liao, L, Welsh-Bohmer, KA, Browndyke, JN, Kraus, WE, Doraiswamy, PM, Burke, JR, and Sherwood, A. "Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial." Neurology 92, no. 3 (January 2019): e212-e223. Full Text
  - Smith, PJ, Browndyke, JN, Monge, ZA, Harshbarger, TB, James, ML, Gaca, JG, Alexander, JH, Berger, MM, Newman, MF, Milano, CA, Mathew, JP, and Neurologic Outcomes Research Group (NORG), . "Longitudinal Changes in Regional Cerebral Perfusion and Cognition After Cardiac Operation." The Annals of Thoracic Surgery 107, no. 1 (January 2019): 112-118. Full Text Open Access Copy
  - Evered, L, Silbert, B, Knopman, DS, Scott, DA, DeKosky, ST, Rasmussen, LS, Oh, ES, Crosby, G, Berger, M, Eckenhoff, RG, and Nomenclature Consensus Working Group, . "Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018." British Journal of Anaesthesia 121, no. 5 (November 2018): 1005-1012. (Review) Full Text
  - Evered, L, Silbert, B, Knopman, DS, Scott, DA, DeKosky, ST, Rasmussen, LS, Oh, ES, Crosby, G, Berger, M, Eckenhoff, RG, and Nomenclature Consensus Working Group, . "Recommendations for the Nomenclature of Cognitive Change Associated With Anaesthesia and Surgery-2018." Anesthesia and Analgesia 127, no. 5 (November 2018): 1189-1195. Full Text
  - Berger, M, Terrando, N, Smith, SK, Browndyke, JN, Newman, MF, and Mathew, JP. "Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms." Anesthesiology 129, no. 4 (October 2018): 829-851. Full Text
  - Lansky, AJ, Messé, SR, Brickman, AM, Dwyer, M, Bart van der Worp, H, Lazar, RM, Pietras, CG, Abrams, KJ, McFadden, E, Petersen, NH, Browndyke, J, Prendergast, B, Ng, VG, Cutlip, DE, Kapadia, S, Krucoff, MW, Linke, A, Scala Moy, C, Schofer, J, van Es, G-A, Virmani, R, Popma, J, Parides, MK, Kodali, S, Bilello, M, Zivadinov, R, Akar, J, Furie, KL, Gress, D, Voros, S, Moses, J, Greer, D, Forrest, JK, Holmes, D, Kappetein, AP, Mack, M, and Baumbach, A. "Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative." European Heart Journal 39, no. 19 (May 2018): 1687-1697. Full Text
  - Klinger, RY, James, OG, Borges-Neto, S, Bisanar, T, Li, Y-J, Qi, W, Berger, M, Terrando, N, Newman, MF, Doraiswamy, PM, Mathew, JP, Alzheimer’s Disease Neuroimaging Initiative (ADNI) Study Group, , and Neurologic Outcomes Research Group (NORG), . "18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery." Anesthesiology 128, no. 4 (April 2018): 728-744. Full Text
  - Browndyke, JN, and Heflin, MT. "Cognition and brain changes associated with high-dose atorvastatin: A BOLD proposition?." American Heart Journal 197 (March 2018): 163-165. Full Text Open Access Copy
  - Skrobot, OA, Black, SE, Chen, C, DeCarli, C, Erkinjuntti, T, Ford, GA, Kalaria, RN, O'Brien, J, Pantoni, L, Pasquier, F, Roman, GC, Wallin, A, Sachdev, P, Skoog, I, VICCCS group, , Ben-Shlomo, Y, Passmore, AP, Love, S, and Kehoe, PG. "Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 14, no. 3 (March 2018): 280-292. Full Text
  - Zietlow, K, McDonald, SR, Sloane, R, Browndyke, J, Lagoo-Deenadayalan, S, and Heflin, MT. "Preoperative Cognitive Impairment As a Predictor of Postoperative Outcomes in a Collaborative Care Model." Journal of the American Geriatrics Society 66, no. 3 (March 2018): 584-589. Full Text Open Access Copy
  - Browndyke, JN, Berger, M, Smith, PJ, Harshbarger, TB, Monge, ZA, Panchal, V, Bisanar, TL, Glower, DD, Alexander, JH, Cabeza, R, Welsh-Bohmer, K, Newman, MF, Mathew, JP, and Duke Neurologic Outcomes Research Group (NORG), . "Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults." Human Brain Mapping 39, no. 2 (February 2018): 985-1003. Full Text Open Access Copy
  - Mack, MJ, Acker, MA, Gelijns, AC, Overbey, JR, Parides, MK, Browndyke, JN, Groh, MA, Moskowitz, AJ, Jeffries, NO, Ailawadi, G, Thourani, VH, Moquete, EG, Iribarne, A, Voisine, P, Perrault, LP, Bowdish, ME, Bilello, M, Davatzikos, C, Mangusan, RF, Winkle, RA, Smith, PK, Michler, RE, Miller, MA, O'Sullivan, KL, Taddei-Peters, WC, Rose, EA, Weisel, RD, Furie, KL, Bagiella, E, Moy, CS, O'Gara, PT, Messé, SR, and Cardiothoracic Surgical Trials Network (CTSN), . "Effect of Cerebral Embolic Protection Devices on CNS Infarction in Surgical Aortic Valve Replacement: A Randomized Clinical Trial." Jama 318, no. 6 (August 2017): 536-547. Full Text
  - Blumenthal, JA, Smith, PJ, Mabe, S, Hinderliter, A, Welsh-Bohmer, K, Browndyke, JN, Lin, P-H, Kraus, W, Doraiswamy, PM, Burke, J, and Sherwood, A. "Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment." Psychosomatic Medicine 79, no. 6 (July 2017): 719-727. Full Text
  - Skrobot, OA, O'Brien, J, Black, S, Chen, C, DeCarli, C, Erkinjuntti, T, Ford, GA, Kalaria, RN, Pantoni, L, Pasquier, F, Roman, GC, Wallin, A, Sachdev, P, Skoog, I, VICCCS group, , Ben-Shlomo, Y, Passmore, AP, Love, S, and Kehoe, PG. "The Vascular Impairment of Cognition Classification Consensus Study." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 13, no. 6 (June 2017): 624-633. Full Text
  - Lansky, AJ, Messé, SR, Brickman, AM, Dwyer, M, van der Worp, HB, Lazar, RM, Pietras, CG, Abrams, KJ, McFadden, E, Petersen, NH, Browndyke, J, Prendergast, B, Ng, VG, Cutlip, DE, Kapadia, S, Krucoff, MW, Linke, A, Moy, CS, Schofer, J, van Es, G-A, Virmani, R, Popma, J, Parides, MK, Kodali, S, Bilello, M, Zivadinov, R, Akar, J, Furie, KL, Gress, D, Voros, S, Moses, J, Greer, D, Forrest, JK, Holmes, D, Kappetein, AP, Mack, M, and Baumbach, A. "Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative." Journal of the American College of Cardiology 69, no. 6 (February 2017): 679-691. (Review) Full Text
  - Browndyke, JN, Berger, M, Harshbarger, TB, Smith, PJ, White, W, Bisanar, TL, Alexander, JH, Gaca, JG, Welsh-Bohmer, K, Newman, MF, and Mathew, JP. "Resting-State Functional Connectivity and Cognition After Major Cardiac Surgery in Older Adults without Preoperative Cognitive Impairment: Preliminary Findings." Journal of the American Geriatrics Society 65, no. 1 (January 2017): e6-e12. Full Text Open Access Copy
  - Giattino, CM, Gardner, JE, Sbahi, FM, Roberts, KC, Cooter, M, Moretti, E, Browndyke, JN, Mathew, JP, Woldorff, MG, Berger, M, and MADCO-PC Investigators, . "Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults." Frontiers in Systems Neuroscience 11 (January 2017): 24-null. Full Text Open Access Copy
  - Melton, MS, Browndyke, JN, Harshbarger, TB, Madden, DJ, Nielsen, KC, and Klein, SM. "Changes in Brain Resting-state Functional Connectivity Associated with Peripheral Nerve Block: A Pilot Study." Anesthesiology 125, no. 2 (August 2016): 368-377. Full Text Open Access Copy
  - Gillinov, AM, Bagiella, E, Moskowitz, AJ, Raiten, JM, Groh, MA, Bowdish, ME, Ailawadi, G, Kirkwood, KA, Perrault, LP, Parides, MK, Smith, RL, Kern, JA, Dussault, G, Hackmann, AE, Jeffries, NO, Miller, MA, Taddei-Peters, WC, Rose, EA, Weisel, RD, Williams, DL, Mangusan, RF, Argenziano, M, Moquete, EG, O'Sullivan, KL, Pellerin, M, Shah, KJ, Gammie, JS, Mayer, ML, Voisine, P, Gelijns, AC, O'Gara, PT, Mack, MJ, and CTSN, . "Rate Control versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery." The New England Journal of Medicine 374, no. 20 (May 2016): 1911-1921. Full Text
  - Michler, RE, Smith, PK, Parides, MK, Ailawadi, G, Thourani, V, Moskowitz, AJ, Acker, MA, Hung, JW, Chang, HL, Perrault, LP, Gillinov, AM, Argenziano, M, Bagiella, E, Overbey, JR, Moquete, EG, Gupta, LN, Miller, MA, Taddei-Peters, WC, Jeffries, N, Weisel, RD, Rose, EA, Gammie, JS, DeRose, JJ, Puskas, JD, Dagenais, F, Burks, SG, El-Hamamsy, I, Milano, CA, Atluri, P, Voisine, P, O'Gara, PT, Gelijns, AC, and CTSN, . "Two-Year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation." The New England Journal of Medicine 374, no. 20 (May 2016): 1932-1941. Full Text
  - Greco, G, Ferket, BS, D'Alessandro, DA, Shi, W, Horvath, KA, Rosen, A, Welsh, S, Bagiella, E, Neill, AE, Williams, DL, Greenberg, A, Browndyke, JN, Gillinov, AM, Mayer, ML, Keim-Malpass, J, Gupta, LS, Hohmann, SF, Gelijns, AC, O'Gara, PT, and Moskowitz, AJ. "Diabetes and the Association of Postoperative Hyperglycemia With Clinical and Economic Outcomes in Cardiac Surgery." Diabetes Care 39, no. 3 (March 2016): 408-417. Full Text
  - Foster, CM, Addis, DR, Ford, JH, Kaufer, DI, Burke, JR, Browndyke, JN, Welsh-Bohmer, KA, and Giovanello, KS. "Prefrontal contributions to relational encoding in amnestic mild cognitive impairment." Neuroimage. Clinical 11 (January 15, 2016): 158-166. Full Text
  - Goldstein, D, Moskowitz, AJ, Gelijns, AC, Ailawadi, G, Parides, MK, Perrault, LP, Hung, JW, Voisine, P, Dagenais, F, Gillinov, AM, Thourani, V, Argenziano, M, Gammie, JS, Mack, M, Demers, P, Atluri, P, Rose, EA, O'Sullivan, K, Williams, DL, Bagiella, E, Michler, RE, Weisel, RD, Miller, MA, Geller, NL, Taddei-Peters, WC, Smith, PK, Moquete, E, Overbey, JR, Kron, IL, O'Gara, PT, Acker, MA, and CTSN, . "Two-Year Outcomes of Surgical Treatment of Severe Ischemic Mitral Regurgitation." The New England Journal of Medicine 374, no. 4 (January 2016): 344-353. Full Text
  - Berger, M, Nadler, JW, Browndyke, J, Terrando, N, Ponnusamy, V, Cohen, HJ, Whitson, HE, and Mathew, JP. "Postoperative Cognitive Dysfunction: Minding the Gaps in Our Knowledge of a Common Postoperative Complication in the Elderly." Anesthesiology Clinics 33, no. 3 (September 2015): 517-550. (Review) Full Text
  - Berger, M, Browndyke, J, and Mathew, JP. "Intraoperative Glycemic Control to Prevent Delirium after Cardiac Surgery: Steering a Course between Scylla and Charybdis." Anesthesiology 122, no. 6 (June 2015): 1186-1188. Full Text
  - Kron, IL, Hung, J, Overbey, JR, Bouchard, D, Gelijns, AC, Moskowitz, AJ, Voisine, P, O'Gara, PT, Argenziano, M, Michler, RE, Gillinov, M, Puskas, JD, Gammie, JS, Mack, MJ, Smith, PK, Sai-Sudhakar, C, Gardner, TJ, Ailawadi, G, Zeng, X, O'Sullivan, K, Parides, MK, Swayze, R, Thourani, V, Rose, EA, Perrault, LP, Acker, MA, and CTSN Investigators, . "Predicting recurrent mitral regurgitation after mitral valve repair for severe ischemic mitral regurgitation." The Journal of thoracic and cardiovascular surgery 149, no. 3 (March 2015): 752-61.e1. Full Text
  - Smith, PK, Puskas, JD, Ascheim, DD, Voisine, P, Gelijns, AC, Moskowitz, AJ, Hung, JW, Parides, MK, Ailawadi, G, Perrault, LP, Acker, MA, Argenziano, M, Thourani, V, Gammie, JS, Miller, MA, Pagé, P, Overbey, JR, Bagiella, E, Dagenais, F, Blackstone, EH, Kron, IL, Goldstein, DJ, Rose, EA, Moquete, EG, Jeffries, N, Gardner, TJ, O'Gara, PT, Alexander, JH, Michler, RE, and Cardiothoracic Surgical Trials Network Investigators, . "Surgical treatment of moderate ischemic mitral regurgitation." The New England Journal of Medicine 371, no. 23 (December 2014): 2178-2188. Full Text
  - Hayden, KM, Kuchibhatla, M, Romero, HR, Plassman, BL, Burke, JR, Browndyke, JN, and Welsh-Bohmer, KA. "Pre-clinical cognitive phenotypes for Alzheimer disease: a latent profile approach." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry 22, no. 11 (November 2014): 1364-1374. Full Text
  - Hayden, KM, Kuchibhatla, M, Romero, HR, Plassman, BL, Burke, JR, Browndyke, JN, and Welsh-Bohmer, KA. "Pre-clinical cognitive phenotypes for alzheimer disease: A latent profile approach." American Journal of Geriatric Psychiatry 22, no. 11 (2014): 1364-1374. Full Text
  - Browndyke, JN, and Mathew, JP. "Neurological injury after transcatheter aortic valve implantation: are the trees falling silently or is our hearing impaired?." Circ Cardiovasc Interv 6, no. 6 (December 2013): 599-601. Full Text Open Access Copy Link to Item
  - Browndyke, JN, and Mathew, JP. "Neurological Injury After Transcatheter Aortic Valve Implantation Are the Trees Falling Silently or Is Our Hearing Impaired?." CIRCULATION-CARDIOVASCULAR INTERVENTIONS 6, no. 6 (December 2013): 599-601. Full Text Link to Item
  - Mathew, JP, White, WD, Schinderle, DB, Podgoreanu, MV, Berger, M, Milano, CA, Laskowitz, DT, Stafford-Smith, M, Blumenthal, JA, Newman, MF, and Neurologic Outcome Research Group (NORG) of The Duke Heart Center, . "Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery." Stroke 44, no. 12 (December 2013): 3407-3413. Full Text
  - Browndyke, JN, Giovanello, K, Petrella, J, Hayden, K, Chiba-Falek, O, Tucker, KA, Burke, JR, and Welsh-Bohmer, KA. "Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease." Alzheimers Dement 9, no. 3 (May 2013): 284-294. Full Text Open Access Copy Link to Item
  - Fontes, MT, Swift, RC, Phillips-Bute, B, Podgoreanu, MV, Stafford-Smith, M, Newman, MF, Mathew, JP, and Neurologic Outcome Research Group of the Duke Heart Center, . "Predictors of cognitive recovery after cardiac surgery." Anesthesia and Analgesia 116, no. 2 (February 2013): 435-442. Full Text
  - Blumenthal, JA, Smith, PJ, Welsh-Bohmer, K, Babyak, MA, Browndyke, J, Lin, P-H, Doraiswamy, PM, Burke, J, Kraus, W, Hinderliter, A, and Sherwood, A. "Can lifestyle modification improve neurocognition? Rationale and design of the ENLIGHTEN clinical trial." Contemp Clin Trials 34, no. 1 (January 2013): 60-69. Full Text Link to Item
  - Browndyke, JN, Giovanello, K, Petrella, J, Hayden, K, Chiba-Falek, O, Tucker, KA, Burke, JR, and Welsh-Bohmer, KA. "Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease." Alzheimer's and Dementia 9, no. 3 (2013): 284-294. Full Text
  - Giovanello, KS, De Brigard, F, Hennessey Ford, J, Kaufer, DI, Burke, JR, Browndyke, JN, and Welsh-Bohmer, KA. "Event-related functional magnetic resonance imaging changes during relational retrieval in normal aging and amnestic mild cognitive impairment." Journal of the International Neuropsychological Society : Jins 18, no. 5 (September 2012): 886-897. Full Text
  - Wee, C-Y, Yap, P-T, Zhang, D, Denny, K, Browndyke, JN, Potter, GG, Welsh-Bohmer, KA, Wang, L, and Shen, D. "Identification of MCI individuals using structural and functional connectivity networks." Neuroimage 59, no. 3 (February 2012): 2045-2056. Full Text
  - Wee, C-Y, Yap, P-T, Denny, K, Browndyke, JN, Potter, GG, Welsh-Bohmer, KA, Wang, L, and Shen, D. "Resting-state multi-spectrum functional connectivity networks for identification of MCI patients." Plos One 7, no. 5 (January 2012): e37828-null. Full Text
  - Hayden, KM, Jones, RN, Zimmer, C, Plassman, BL, Browndyke, JN, Pieper, C, Warren, LH, and Welsh-Bohmer, KA. "Factor structure of the National Alzheimer's Coordinating Centers uniform dataset neuropsychological battery: an evaluation of invariance between and within groups over time." Alzheimer Disease and Associated Disorders 25, no. 2 (April 2011): 128-137. Full Text
  - Tosun, D, Schuff, N, Mathis, CA, Jagust, W, Weiner, MW, and Alzheimer's Disease NeuroImaging Initiative, . "Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment." Brain : a journal of neurology 134, no. Pt 4 (April 2011): 1077-1088. Full Text
  - Kauwe, JSK, Cruchaga, C, Karch, CM, Sadler, B, Lee, M, Mayo, K, Latu, W, Su'a, M, Fagan, AM, Holtzman, DM, Morris, JC, Alzheimer's Disease Neuroimaging Initiative, , and Goate, AM. "Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease." PloS one 6, no. 2 (February 9, 2011): e15918-. Full Text
  - Wee, C-Y, Yap, P-T, Li, W, Denny, K, Browndyke, JN, Potter, GG, Welsh-Bohmer, KA, Wang, L, and Shen, D. "Enriched white matter connectivity networks for accurate identification of MCI patients." Neuroimage 54, no. 3 (February 2011): 1812-1822. Full Text
  - Carmichael, O, Schwarz, C, Drucker, D, Fletcher, E, Harvey, D, Beckett, L, Jack, CR, Weiner, M, DeCarli, C, and Alzheimer's Disease Neuroimaging Initiative, . "Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative." Archives of Neurology 67, no. 11 (November 2010): 1370-1378. Full Text
  - Wee, CY, Yap, PT, Brownyke, JN, Potter, GG, Steffens, DC, Welsh-Bohmer, K, Wang, L, and Shen, D. "Accurate identification of MCI patients via enriched white-matter connectivity network." Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 6357 LNCS (October 25, 2010): 140-147. Full Text
  - Dennis, NA, Browndyke, JN, Stokes, J, Need, A, Burke, JR, Welsh-Bohmer, KA, and Cabeza, R. "Temporal lobe functional activity and connectivity in young adult APOE varepsilon4 carriers." Alzheimers Dement 6, no. 4 (July 2010): 303-311. Full Text Link to Item
  - Hill, BD, Barkemeyer, CA, Jones, GN, Santa Maria, MP, Minor, KS, and Browndyke, JN. "Validation of the coin rotation test: a simple, inexpensive, and convenient screening tool for impaired psychomotor processing speed." The Neurologist 16, no. 4 (July 2010): 249-253. Full Text
  - Smith, PJ, Blumenthal, JA, Babyak, MA, Craighead, L, Welsh-Bohmer, KA, Browndyke, JN, Strauman, TA, and Sherwood, A. "Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure." Hypertension (Dallas, Tex. : 1979) 55, no. 6 (June 2010): 1331-1338. Full Text
  - Smith, PJ, Blumenthal, JA, Hoffman, BM, Cooper, H, Strauman, TA, Welsh-Bohmer, K, Browndyke, JN, and Sherwood, A. "Aerobic exercise and neurocognitive performance: A meta-analytic review of randomized controlled trials." Psychosomatic Medicine 72, no. 3 (April 1, 2010): 239-252. Full Text Open Access Copy
  - Romero, HR, Browndyke, JN, Burke, JR, Hayden, KM, and Welsh-Bohmer, KA. "Executive Measures are Related to Functional Ability in an Ethnically Diverse Cohort." CLINICAL NEUROPSYCHOLOGIST 24, no. 4 (2010): 599-600. Link to Item
  - Smith, PJ, Blumenthal, JA, Hoffman, BM, Browndyke, JN, Welsh Bohmer, KA, Strauman, TJ, and Sherwood, A. "Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure." Hypertension 55 (2010): 1296-1298. (Academic Article) Open Access Copy
  - Linnertz, C, Saucier, L, Ge, D, Cronin, KD, Burke, JR, Browndyke, JN, Hulette, CM, Welsh-Bohmer, KA, and Chiba-Falek, O. "Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues." Plos One 4, no. 10 (October 16, 2009): e7480-null. Full Text
  - Browndyke, JN, Paskavitz, J, Sweet, LH, Cohen, RA, Tucker, KA, Welsh-Bohmer, KA, Burke, JR, and Schmechel, DE. "Neuroanatomical correlates of malingered memory impairment: event-related fMRI of deception on a recognition memory task." Brain Injury 22, no. 6 (June 2008): 481-489. Full Text
  - Schmechel, DE, Browndyke, J, and Ghio, A. "Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders." Neurotoxicology 27, no. 5 (September 2006): 637-657. Full Text Link to Item
  - Akomolafe, A, Lunetta, KL, Erlich, PM, Cupples, LA, Baldwin, CT, Huyck, M, Green, RC, Farrer, LA, Auerbach, S, Griffith, P, Ofili, E, Browndyke, J, Schmechel, D, Welsh-Bohmer, K, Chui, H, DeCarli, C, Duara, R, Foroud, T, Farlow, M, Friedland, R, Go, R, Kurz, A, Obisesan, T, Petrovitch, H, White, L, Relkin, N, Sabbagh, M, Sadovnick, D, and Tsolaki, M. "Genetic association between endothelial nitric oxide synthase and Alzheimer disease." Clinical Genetics 70, no. 1 (2006): 49-56. Full Text
  - Erlich, PM, Lunetta, KL, Cupples, LA, Huyck, M, Green, RC, Baldwin, CT, Farrer, LA, Auerbach, S, Akomolafe, A, Griffith, P, Ofili, E, Browndyke, J, Schmechel, D, Welsh-Bohmer, K, Chui, H, DeCarli, C, Duara, R, Foroud, T, Farlow, M, Friedland, R, Go, R, Kurz, A, Obisesan, T, Petrovitch, H, White, L, Relkin, N, Sabbagh, M, Sadovnick, D, and Tsolaki, M. "Polymorphisms in the PON gene cluster are associated with Alzheimer disease." Human Molecular Genetics 15, no. 1 (2006): 77-85. Full Text
  - Sweet, LH, Paskavitz, JF, O'Connor, MJ, Browndyke, JN, Wellen, JW, and Cohen, RA. "FMRI correlates of the WAIS-III symbol search subtest." J Int Neuropsychol Soc 11, no. 4 (July 2005): 471-476. Link to Item
  - Gunstad, J, Brickman, AM, Paul, RH, Browndyke, J, Moser, DJ, Ott, BR, Gordon, N, Haque, O, and Cohen, RA. "Progressive morphometric and cognitive changes in vascular dementia." Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists 20, no. 2 (March 2005): 229-241. Full Text
  - "Ethical challenges with the use of information technology and telecommunications in neuropsychology, Part I." (November 11, 2004): 195-207. (Chapter) Full Text
  - Tucker, KA, Potenza, MN, Beauvais, JE, Browndyke, JN, Gottschalk, PC, and Kosten, TR. "Perfusion abnormalities and decision making in cocaine dependence." Biol Psychiatry 56, no. 7 (October 1, 2004): 527-530. Full Text Link to Item
  - Garrett, KD, Browndyke, JN, Whelihan, W, Paul, RH, DiCarlo, M, Moser, DJ, Cohen, RA, and Ott, BR. "The neuropsychological profile of vascular cognitive impairment--no dementia: comparisons to patients at risk for cerebrovascular disease and vascular dementia." Arch Clin Neuropsychol 19, no. 6 (September 2004): 745-757. Full Text Link to Item
  - Gouvier, WD, Pinkston, JB, Lovejoy, JC, Smith, SR, Bray, GA, Santa Maria, MP, Hammer, JH, Hilsabeck, RC, Smiroldo, B, Bentz, B, and Browndyke, J. "Erratum: Neuropsychological and emotional changes during simulated microgravity: Effects of triiodothyronine, alendronate, and testosterone (Archives of Clinical Neuropsychology (2004) 19 (153-163) DOI: 10.1016/j.acn.2002.09.001)." Archives of Clinical Neuropsychology 19, no. 4 (June 1, 2004): 595-null. Full Text
  - Tucker, KA, Browndyke, JN, Gottschalk, PC, Cofrancesco, AT, and Kosten, TR. "Gender-specific vulnerability for rCBF abnormalities among cocaine abusers." Neuroreport 15, no. 5 (April 9, 2004): 797-801. Link to Item
  - Browndyke, JN, Tucker, KA, Woods, SP, Beauvals, J, Cohen, RA, Gottschalk, PC, and Kosten, TR. "Examining the effect of cerebral perfusion abnormality magnitude on cognitive performance in recently abstinent chronic cocaine abusers." Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging 14, no. 2 (April 2004): 162-169. Full Text
  - Gouvier, WD, Pinkston, JB, Lovejoy, JC, Smith, SR, Bray, GA, Maria, MPS, Hammer, JH, Hilsabeck, RC, Smiroldo, B, Bentz, B, and Browndyke, J. "Neuropsychological and emotional changes during simulated microgravity: Effects of triiodothyronine, alendronate, and testosterone." Archives of Clinical Neuropsychology 19, no. 2 (2004): 153-163. Full Text
  - Sweet, LH, Paul, RH, Cohen, RA, Moser, D, Ott, BR, Gordon, N, Browndyke, JN, Shah, P, and Garrett, KD. "Neuroimaging correlates of dementia rating scale performance at baseline and 12-month follow-up among patients with vascular dementia." J Geriatr Psychiatry Neurol 16, no. 4 (December 2003): 240-244. Full Text Link to Item
  - Cohen, RA, Browndyke, JN, Moser, DJ, Paul, RH, Gordon, N, and Sweet, L. "Long-term citicoline (cytidine diphosphate choline) use in patients with vascular dementia: neuroimaging and neuropsychological outcomes." Cerebrovascular Diseases (Basel, Switzerland) 16, no. 3 (January 2003): 199-204. Full Text
  - Paul, RH, Cohen, RA, Moser, DJ, Browndyke, JN, Davis, K, Gordon, N, Sweet, L, Lawrence, JJ, and Zawacki, T. "Sensitivity of the dementia rating scale in vascular dementia: comparison between two sets of criteria to define cognitive impairment." Cerebrovasc Dis 15, no. 1-2 (2003): 116-120. Full Text Link to Item
  - Paul, RH, Cohen, RA, Moser, DJ, Ott, BR, Sethi, M, Sweet, L, Browndyke, J, Malloy, P, and Garrett, K. "Clinical correlates of cognitive decline in vascular dementia." Cognitive and Behavioral Neurology 16, no. 1 (2003): 40-46. Full Text
  - Browndyke, JN, Moser, DJ, Cohen, RA, O'Brien, DJ, Algina, JJ, Haynes, WG, Staples, ED, Alexander, J, Davies, LK, and Bauer, RM. "Acute neuropsychological functioning following cardiosurgical interventions associated with the production of intraoperative cerebral microemboli." The Clinical Neuropsychologist 16, no. 4 (December 2002): 463-471. Full Text
  - Browndyke, JN, Tucker, KA, Sweet, LH, Paul, RH, and Cohen, RA. "The effects of gender and time on regional cortical perfusion in vascular dementia patients." ARCHIVES OF CLINICAL NEUROPSYCHOLOGY 17, no. 8 (November 2002): 747-747. Link to Item
  - Sweet, LH, Paul, RH, Browndyke, JN, and Cohen, RA. "Neuroimaging correlates of Dementia Rating Scale performance at baseline and 12-month followup among patients with vascular dementia." ARCHIVES OF CLINICAL NEUROPSYCHOLOGY 17, no. 8 (November 2002): 762-762. Link to Item
  - Tucker, KA, Browndyke, JN, Gouvier, WD, Beauvais, J, Gottschalk, C, and Kosten, T. "Examination of the relative contribution of cocaine and alcohol to neuropsychological functioning." ARCHIVES OF CLINICAL NEUROPSYCHOLOGY 17, no. 8 (November 2002): 814-814. Link to Item
  - Schatz, P, and Browndyke, J. "Applications of computer-based neuropsychological assessment." The Journal of Head Trauma Rehabilitation 17, no. 5 (October 2002): 395-410. (Review) Full Text
  - Browndyke, JN, Albert, AL, Malone, W, Schatz, P, Paul, RH, Cohen, RA, Tucker, KA, and Gouvier, WD. "Computer-related anxiety: examining the impact of technology-specific affect on the performance of a computerized neuropsychological assessment measure." Appl Neuropsychol 9, no. 4 (2002): 210-218. Full Text Link to Item
  - Murero, M, D'Ancona, G, and Karamanoukian, H. "Use of the Internet by patients before and after cardiac surgery: telephone survey." Journal of Medical Internet Research 3, no. 3 (July 2001): E27-null. Full Text
  - Paul, R, Moser, D, Cohen, R, Browndyke, J, Zawacki, T, and Gordon, N. "Dementia severity and pattern of cognitive performance in vascular dementia." Applied Neuropsychology 8, no. 4 (2001): 211-217. Full Text
  - Pinkston, JB, Gouvier, WD, Browndyke, JN, and Varnado, PJ. "Chronic neuropsychological effects of long-term mercury exposure: A longitudinal study." Archives of Clinical Neuropsychology 14, no. 8 (November 1, 1999): 659-659. Full Text
  - Browndyke, JN, Gouvier, WD, and Waters, WF. "Predictors of ANS sympathetic activity and intensity in a large scale MHI population: Online neuropsychology project II." Archives of Clinical Neuropsychology 14, no. 1 (January 1, 1999): 26-27. Full Text
  - Schatz, P, and Browndyke, J. "Trends in computer usage and means of obtaining CE credits among professional psychologists." Archives of Clinical Neuropsychology 14, no. 1 (January 1, 1999): 159-159. Full Text
  - Browndyke, JN, Gouvier, WD, Waters, WF, Johnson, JA, and Russell, L. "The effects of mild head injury and postconcussive symptomology on the skin conductance orienting response." Archives of Clinical Neuropsychology 13, no. 1 (February 1, 1998): 132-132. Full Text
  - Browndyke, JN, Maria, MPS, Pinkston, JB, and Gouvier, WD. "Online neuropsychology project: A survey of general head injury and prevention knowledge between professionals and non-professionals." Archives of Clinical Neuropsychology 13, no. 1 (February 1, 1998): 133-133. Full Text
  - Barkemeyer, CA, Santa Maria, MP, Browndyke, JN, Callon, EB, and Dunn, AM. "The coin rotation task: A convenient and sensitive measure of fine motor control." ARCHIVES OF CLINICAL NEUROPSYCHOLOGY 13, no. 1 (January 1998): 18-18. Full Text Link to Item
  - Hilsabeck, RC, Browndyke, JN, Gouvier, WD, and Jones, J. "Convergent and discriminant validity of the memory assessment scales (MAS)." ARCHIVES OF CLINICAL NEUROPSYCHOLOGY 13, no. 1 (January 1998): 25-26. Link to Item
  - Santa Maria, MP, Pinkston, JB, Browndyke, JN, and Drew Gouvier, W. "Fine tuning the graphesthesia assessment: one stroke versus two." Appl Neuropsychol 4, no. 2 (1997): 127-129. Full Text Link to Item
- Conference Papers
  - Devinney, MJ, Smith, PJ, Spector, AR, Cheong, Y, Wickenheisser, VA, Browndyke, JN, Cooter, M, Mathew, JP, and Berger, M. "The Association of Obstructive Sleep Apnea Risk with Postoperative Cognitive Decline." Annual Scientific Meeting of the American-Geriatrics-Society (AGS). Portland, OR. May 2, 2019 - May 4, 2019.: WILEY, April 1, 2019. Link to Item
  - Heflin, M, Browndyke, JN, Lagoo, S, Loyack, N, Frede, C, Barrett, H, Mathis, A, Yanamadala, M, and Barbeito, A. "POSH-DREAM: Mobile Point-of-Contact Delirium Risk Assessment & Identification." Annual Scientific Meeting of the American-Geriatrics-Society (AGS). Portland, OR. May 2, 2019 - May 4, 2019.: WILEY, April 1, 2019. Link to Item
  - Oyeyemi, D, Whitson, H, Browndyke, JN, Cohen, HJ, Mathew, JP, and Berger, M. "Depression, Anxiety and Postoperative Cognition in Older Adults." Annual Scientific Meeting of the American-Geriatrics-Society (AGS). Portland, OR. May 2, 2019 - May 4, 2019.: WILEY, April 1, 2019. Link to Item
  - Khan, BA, Chan, C, Lindroth, H, Browndyke, J, Wilson, JE, and Wang, S. "DECONSTRUCTING DELIRIUM: RETHINKING THE ROLE OF BIOMARKERS AND DIAGNOSTIC ANOMALIES." : Elsevier BV, March 2019. Full Text
  - Berger, M, Browndyke, J, Cooter, M, Bullock, W, Colin, B, Gadsden, J, Iboaya, E, Lemm, J, Moretti, E, Ohlendorf, B, Quinones, QJ, Runyon, S, Sandler, A, Young, C, Shaw, L, Whitson, H, Cohen, H, and Mathew, J. "Postoperative Changes in CSF AD Markers, Cognition, and fMRI activity." Annual Scientific Meeting of the American-Geriatrics-Society (AGS). Orlando, FL. May 3, 2018 - May 5, 2018.: WILEY, April 1, 2018. Link to Item
  - Piccini, JP, Browndyke, J, Cooter, M, Bisanar, T, Flynn, A, Fudim, M, Waldron, NH, Newman, MF, Daubert, JP, and Mathew, JP. "Neurocognitive Function in Atrial Fibrillation: Catheter Ablation versus Medical Management." Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium. Anaheim, CA. November 11, 2017 - November 15, 2017.: LIPPINCOTT WILLIAMS & WILKINS, November 14, 2017. Link to Item
  - Browndyke, JN, Wang, S, DeWitt, M, and Boustani, M. "COMING TOGETHER TO FIGHT DELIRIUM: HOW TO DELIVER TEAM-BASED, INTERDISCIPLINARY CARE TO PREVENT, DETECT, AND MANAGE DELIRIUM AND ITS LONG-TERM SEQUELAE." March 2017. Link to Item
  - Wang, S, Smith, PJ, and Browndyke, J. "Delirium and Post-Operative Cognitive Decline: Who is at Risk for the Long-Term Neurocognitive and Neuropsychiatric Effects?." : Elsevier BV, March 2016. Full Text
  - Kamholz, B, Browndyke, JN, and Wang, S. "Frailty, Delirium, and Postoperative Cognitive Decline: What Are the Long-Term Effects of Acute Late-Life Medical and Surgical Events?." March 2015. Full Text
  - Foster, C, Addis, D, Ford, J, Kaufer, D, Browndyke, J, Welsh-Bohmer, K, and Giovanello, K. "PREFRONTAL CONTRIBUTIONS TO RELATIONAL ENCODING IN HEALTHY AGING AND MILD COGNITIVE IMPAIRMENT." 2013. Open Access Copy Link to Item
  - Browndyke, JN, Potter, GG, and Plassman, BL. "P1-109 Verbal recognition memory differences in Alzheimer's disease and vascular dementia: examining recognition response characteristics independent of dementia severity." : Elsevier BV, July 2004. Full Text

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

In the News

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Conference Papers