Scholars@Duke
Jonathan Viventi

Jonathan Viventi

Hawkins Family Associate Professor
Biomedical Engineering
j.viventi@duke.edu
1149 CIEMAS, Durham, NC 27708
1149 CIEMAS, Durham, NC 27708

Selected Publications

Efficient, automated escape routing for high-density pad grids: deepest-exit-first algorithm for layer and wire count optimization.

Journal Article Journal of neural engineering · June 2025 Objective.The burgeoning demand for higher channel count neural interfaces has led to the incorporation of large connectors for connecting electrode channels to recording systems or on-site wireless electronics. However, as these devices are size-co ... Full text Cite

Supracortical Microstimulation: Advances in Microelectrode Design and In Vivo Validation.

Journal Article Annual review of biomedical engineering · May 2025 Electrical stimulation of the brain is being developed as a treatment for an increasing number of neurological disorders. Technologies for delivering electrical stimulation are advancing rapidly and vary in specificity, coverage, and invasiveness. Supracor ... Full text Cite

Intan Technologies integrated circuits can produce analog-to-digital conversion artifacts that affect neural signal acquisition.

Journal Article Journal of neural engineering · July 2024 Objective.Intan Technologies' integrated circuits (ICs) are valuable tools for neurophysiological data acquisition, providing signal amplification, filtering, and digitization from many channels (up to 64 channels/chip) at high sampling rates (up to ... Full text Cite

High-density cortical µECoG arrays concurrently track spreading depolarizations and long-term evolution of stroke in awake rats.

Journal Article Commun Biol · March 4, 2024 Spreading depolarizations (SDs) are widely recognized as a major contributor to the progression of tissue damage from ischemic stroke even if blood flow can be restored. They are characterized by negative intracortical waveforms of up to -20 mV, propagatio ... Full text Link to item Cite

Cerebellar activity in hemi-parkinsonian rats during volitional gait and freezing.

Journal Article Brain communications · January 2024 Parkinson's disease is a neurodegenerative disease characterized by gait dysfunction in the advanced stages of the disease. The unilateral 6-hydroxydopamine toxin-induced model is the most studied animal model of Parkinson's disease, which reproduces gait ... Full text Cite

Cerebellar activity in PINK1 knockout rats during volitional gait.

Journal Article Brain communications · January 2024 Preclinical models of Parkinson's disease are imperative to gain insight into the neural circuits that contribute to gait dysfunction in advanced stages of the disease. A PTEN-induced putative kinase 1 knockout early-onset model of Parkinson's disease may ... Full text Cite

High-resolution neural recordings improve the accuracy of speech decoding.

Journal Article Nat Commun · November 6, 2023 Patients suffering from debilitating neurodegenerative diseases often lose the ability to communicate, detrimentally affecting their quality of life. One solution to restore communication is to decode signals directly from the brain to enable neural speech ... Full text Link to item Cite

Flexible, high-resolution cortical arrays with large coverage capture microscale high-frequency oscillations in patients with epilepsy.

Journal Article Epilepsia · July 2023 OBJECTIVE: Effective surgical treatment of drug-resistant epilepsy depends on accurate localization of the epileptogenic zone (EZ). High-frequency oscillations (HFOs) are potential biomarkers of the EZ. Previous research has shown that HFOs often occur wit ... Full text Link to item Cite

A Soft, High-Density Neuroelectronic Array.

Journal Article Npj flexible electronics · January 2023 Techniques to study brain activities have evolved dramatically, yet tremendous challenges remain in acquiring high-throughput electrophysiological recordings minimally invasively. Here, we develop an integrated neuroelectronic array that is filamentary, hi ... Full text Cite

Design and Simulation of a Low Power 384-channel Actively Multiplexed Neural Interface.

Conference IEEE Biomedical Circuits and Systems Conference : healthcare technology : [proceedings]. IEEE Biomedical Circuits and Systems Conference · October 2022 Brain computer interfaces (BCIs) provide clinical benefits including partial restoration of lost motor control, vision, speech, and hearing. A fundamental limitation of existing BCIs is their inability to span several areas (> cm2) of the cortex ... Full text Open Access Cite

Flexural bending to approximate cortical forces exerted by electrocorticography (ECoG) arrays.

Journal Article Journal of neural engineering · August 2022 Objective.The force that an electrocorticography (ECoG) array exerts on the brain manifests when it bends to match the curvature of the skull and cerebral cortex. This force can negatively impact both short-term and long-term patient outcomes. Here ... Full text Cite

Electrophysiology and Arrhythmogenesis in the Human Right Ventricular Outflow Tract.

Journal Article Circulation. Arrhythmia and electrophysiology · March 2022 BackgroundRight ventricular outflow tract (RVOT) is a common source of ventricular tachycardia, which often requires ablation. However, the mechanisms underlying the RVOT's unique arrhythmia susceptibility remain poorly understood due to lack of d ... Full text Cite

High-Density, Actively Multiplexed μECoG Array on Reinforced Silicone Substrate.

Journal Article Frontiers in nanotechnology · January 2022 Simultaneous interrogation of electrical signals from wide areas of the brain is vital for neuroscience research and can aid in understanding the mechanisms of brain function and treatments for neurological disorders. There emerges a demand for development ... Full text Cite

Intraoperative microseizure detection using a high-density micro-electrocorticography electrode array.

Journal Article Brain Commun · 2022 One-third of epilepsy patients suffer from medication-resistant seizures. While surgery to remove epileptogenic tissue helps some patients, 30-70% of patients continue to experience seizures following resection. Surgical outcomes may be improved with more ... Full text Open Access Link to item Cite

Flexible, high-resolution thin-film electrodes for human and animal neural research.

Journal Article J Neural Eng · June 17, 2021 Objective.Brain functions such as perception, motor control, learning, and memory arise from the coordinated activity of neuronal assemblies distributed across multiple brain regions. While major progress has been made in understanding the function of indi ... Full text Link to item Cite

Sufficient sampling for kriging prediction of cortical potential in rat, monkey, and human µECoG.

Journal Article J Neural Eng · March 8, 2021 Objective. Large channel count surface-based electrophysiology arrays (e.g. µECoG) are high-throughput neural interfaces with good chronic stability. Electrode spacing remains ad hoc due to redundancy and nonstationarity of field dynamics. Here, we establi ... Full text Link to item Cite

A modular high-density μECoG system on macaque vlPFC for auditory cognitive decoding.

Journal Article Journal of neural engineering · July 2020 ObjectiveA fundamental goal of the auditory system is to parse the auditory environment into distinct perceptual representations. Auditory perception is mediated by the ventral auditory pathway, which includes the ventrolateral prefrontal cortex ( ... Full text Cite

Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates.

Journal Article Science translational medicine · April 2020 Long-lasting, high-resolution neural interfaces that are ultrathin and flexible are essential for precise brain mapping and high-performance neuroprosthetic systems. Scaling to sample thousands of sites across large brain regions requires integrating power ... Full text Cite

Ultrathin, High Capacitance Capping Layers for Silicon Electronics with Conductive Interconnects in Flexible, Long-Lived Bioimplants

Journal Article Advanced Materials Technologies · January 1, 2020 Bioimplants that incorporate active electronic components at the tissue interface rely critically on materials that are biocompatible, impermeable to biofluids, and capable of intimate electrical coupling for high-quality, chronically stable operation in v ... Full text Cite

Flexible electronic/optoelectronic microsystems with scalable designs for chronic biointegration.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · July 2019 Flexible biocompatible electronic systems that leverage key materials and manufacturing techniques associated with the consumer electronics industry have potential for broad applications in biomedicine and biological research. This study reports scalable a ... Full text Cite

Simultaneous Recording and Stimulation Instrumentation for Closed Loop Spinal Cord Stimulation

Conference International IEEE EMBS Conference on Neural Engineering Ner · May 16, 2019 Chronic neuropathic pain is a debilitating disorder. Many patients receive pain relief when implanted with a Spinal Cord Stimulation (SCS) system. However, there is currently no way to automatically determine the most effective parameters to use in stimula ... Full text Cite

Artefact-free wireless closed-loop device.

Journal Article Nature biomedical engineering · January 2019 Full text Cite

Long-term recording reliability of liquid crystal polymer µECoG arrays.

Journal Article Journal of neural engineering · December 2018 ObjectiveThe clinical use of microsignals recorded over broad cortical regions is largely limited by the chronic reliability of the implanted interfaces.ApproachWe evaluated the chronic reliability of novel 61-channel micro-electrocortico ... Full text Cite

Conductively coupled flexible silicon electronic systems for chronic neural electrophysiology.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · October 2018 Materials and structures that enable long-term, intimate coupling of flexible electronic devices to biological systems are critically important to the development of advanced biomedical implants for biological research and for clinical medicine. By compari ... Full text Cite

A Novel µECoG Electrode Interface for Comparison of Local and Common Averaged Referenced Signals.

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · July 2018 Micro-electrocorticography (µECoG) is a minimally invasive neural interface that allows for recording from the surface of the brain with high spatial and temporal resolution [1], [2]. However, discerning multi-unit and local field potential (LFP) activity ... Full text Cite

3D Printed Cranial Window System for Chronic μECoG Recording.

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · July 2018 Chronic studies of flexible μECoG electrodes and the electrode-brain interface have been limited by the inability to assess tissue response over time. The electrophysiological system presented here combines epidural microelectrocorticographic (μECoG) recor ... Full text Cite

A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain.

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · July 2018 Neural circuitry can be investigated and manipulated using a variety of techniques, including electrical and optical recording and stimulation. At present, most neural interfaces are designed to accommodate a single mode of neural recording and/or manipula ... Full text Cite

Long-term prediction of μeCOG signals with a spatio-temporal pyramid of adversarial convolutional networks

Conference Proceedings International Symposium on Biomedical Imaging · May 23, 2018 Video prediction into sufficiently long future has many potential applications. Modeling long-term dynamics for times series is challenging with convolution neural network structure, which is usually good for capturing short-term dependencies. In this work ... Full text Cite

Unsupervised Learning of Spike Patterns for Seizure Detection and Wavefront Estimation of High Resolution Micro Electrocorticographic ( $\mu $ ECoG) Data.

Journal Article IEEE transactions on nanobioscience · September 2017 For the past few years, we have developed flexible, active, and multiplexed recording devices for high resolution recording over large, clinically relevant areas in the brain. While this technology has enabled a much higher-resolution view of the electrica ... Full text Cite

A low-cost, scalable, current-sensing digital headstage for high channel count μECoG.

Journal Article Journal of neural engineering · April 2017 ObjectiveHigh channel count electrode arrays allow for the monitoring of large-scale neural activity at high spatial resolution. Implantable arrays featuring many recording sites require compact, high bandwidth front-end electronics. In the presen ... Full text Cite

Capacitively Coupled Arrays of Multiplexed Flexible Silicon Transistors for Long-Term Cardiac Electrophysiology.

Journal Article Nature biomedical engineering · January 2017 Advanced capabilities in electrical recording are essential for the treatment of heart-rhythm diseases. The most advanced technologies use flexible integrated electronics; however, the penetration of biological fluids into the underlying electronics and an ... Full text Cite

Ultrathin, transferred layers of thermally grown silicon dioxide as biofluid barriers for biointegrated flexible electronic systems.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · October 2016 Materials that can serve as long-lived barriers to biofluids are essential to the development of any type of chronic electronic implant. Devices such as cardiac pacemakers and cochlear implants use bulk metal or ceramic packages as hermetic enclosures for ... Full text Cite

In vitro assessment of long-term reliability of low-cost μECoG arrays.

Conference Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · August 2016 Micro-electrocorticographic (μECοG) electrode arrays provide a minimally invasive, high-resolution neural interface with broad cortical coverage. Previously, we fabricated μECoG arrays at a lower cost than commercially available devices using low-cost indu ... Full text Cite

Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex.

Journal Article Nature materials · July 2016 Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring a ... Full text Cite

Millimeter-scale epileptiform spike propagation patterns and their relationship to seizures.

Journal Article Journal of neural engineering · April 2016 ObjectiveCurrent mapping of epileptic networks in patients prior to epilepsy surgery utilizes electrode arrays with sparse spatial sampling (∼1.0 cm inter-electrode spacing). Recent research demonstrates that sub-millimeter, cortical-column-scale ... Full text Cite

A low-cost, multiplexed μECoG system for high-density recordings in freely moving rodents.

Journal Article Journal of neural engineering · April 2016 ObjectiveMicro-electrocorticography (μECoG) offers a minimally invasive neural interface with high spatial resolution over large areas of cortex. However, electrode arrays with many contacts that are individually wired to external recording system ... Full text Cite

Seizure detection and prediction through clustering and temporal analysis of micro electrocorticographic data

Conference 2015 IEEE Signal Processing in Medicine and Biology Symposium Proceedings · February 11, 2016 We have developed flexible, active, multiplexed recording devices for high resolution recording over large, clinically relevant areas in the brain. While this technology has enabled a much higher-resolution view of the electrical activity of the brain, the ... Full text Cite

Neural mass spatio-temporal modeling from high-density electrode array recordings

Conference 2015 Information Theory and Applications Workshop Ita 2015 Conference Proceedings · October 27, 2015 Neural mass models provide an attractive framework for modeling complex behavior in cortical circuits. The models are based on describing the dynamics of large neural populations through the space and time evolution of a small number of key aggregate stati ... Full text Cite

Semi-chronic chamber system for simultaneous subdural electrocorticography, local field potentials, and spike recordings

Conference International IEEE EMBS Conference on Neural Engineering Ner · July 1, 2015 The brain operates on many different scales, from individual neurons to interacting cortical areas. Similarly, electrophysiology can monitor neural activity at a variety of spatial resolutions. Yet the majority of electrophysiology studies focus on a singl ... Full text Cite

A low-cost, 61-channel μeCoG array for use in rodents

Conference International IEEE EMBS Conference on Neural Engineering Ner · July 1, 2015 Micro-Electrocorticography (μECoG) offers a minimally invasive, high resolution interface with large areas of cortex. A wide variety of μECoG designs have been developed and customized [1]-[4], including active, multiplexed arrays [5] and arrays on dissolv ... Full text Cite

A high-density, high-channel count, multiplexed μECoG array for auditory-cortex recordings.

Journal Article Journal of neurophysiology · September 2014 Featured Publication Our understanding of the large-scale population dynamics of neural activity is limited, in part, by our inability to record simultaneously from large regions of the cortex. Here, we validated the use of a large-scale active microelectrode array that simult ... Full text Cite

Cross-correlation based μECoG waveform tracking.

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · January 2014 Clinical electrodes for epileptic seizure monitoring traditionally require a tradeoff between coverage area and spatial resolution. However, with multiplexed, flexible array devices, high spatial resolution is possible over large surface areas. This high r ... Full text Cite

A low-cost, multiplexed electrophysiology system for chronic μECoG recordings in rodents.

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · January 2014 Featured Publication Micro-Electrocorticography (μECoG) offers a minimally invasive, high resolution interface with large areas of cortex. However, large arrays of electrodes with many contacts that are individually wired to external recording systems are cumbersome and make c ... Full text Cite

Breast cancer detection using high-density flexible electrode arrays and electrical impedance tomography.

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · January 2014 While mammography remains the gold standard for breast cancer screening, additional adjunctive tools for early detection of breast cancer are needed especially for young women, women with dense breast tissue and those at increased risk due to genetic facto ... Full text Cite

A low-cost, open-source, wireless electrophysiology system.

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · January 2014 Featured Publication Many experiments in neuroscience require or would benefit tremendously from a wireless neural recording system. However, commercially available wireless systems are expensive, have moderate to high noise and are often not customizable. Academic wireless sy ... Full text Cite

85 dB dynamic range 1.2 mW 156 kS/s biopotential recording IC for high-density ECoG flexible active electrode array

Conference European Solid State Circuits Conference · December 31, 2013 We present the design, implementation, and experimental characterization of a low-noise low-power biopotential recording integrated circuit (IC) in support of a fully implantable, high-density, actively multiplexed and flexible 32×32 electrode array for el ... Full text Cite

Data acquisition system for high resolution, multiplexed electrode arrays

Conference International IEEE EMBS Conference on Neural Engineering Ner · December 1, 2013 The recent development of novel implantable devices capable of interfacing with the brain using hundreds or thousands of individually controllable microelectrodes has the potential to improve diagnosis and treatment methods for medically refractory epileps ... Full text Cite

Improved clustering of spike patterns through video segmentation and motion analysis of micro electrocorticographic data

Conference 2013 IEEE Signal Processing in Medicine and Biology Symposium Spmb 2013 · January 1, 2013 We have developed flexible, active, multiplexed recording devices for high resolution recording over large, clinically relevant areas in the brain. While this technology has enabled a much higher-resolution view of the electrical activity of the brain, the ... Full text Cite

Proceedings of the Third International Workshop on Advances in Electrocorticography.

Journal Article Epilepsy & behavior : E&B · December 2012 The Third International Workshop on Advances in Electrocorticography (ECoG) was convened in Washington, DC, on November 10-11, 2011. As in prior meetings, a true multidisciplinary fusion of clinicians, scientists, and engineers from many disciplines gather ... Full text Cite

Development of high resolution, multiplexed electrode arrays: Opportunities and challenges.

Conference Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · January 2012 More than one third of the world's 60 million people with epilepsy have seizures that cannot be controlled by medication. Some of these individuals may be candidates for surgical removal of brain regions that generate seizures, but the chance of being seiz ... Full text Cite

Spatiotemporal compression for efficient storage and transmission of high-resolution electrocorticography data.

Conference Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · January 2012 High-resolution Electrocorticography (HR-ECoG) has emerged as a key strategic technology for recording localized neural activity with high temporal and spatial resolution with potential applications in brain-computer interfaces (BCI), and seizure detection ... Full text Cite

Proceedings of the Second International Workshop on Advances in Electrocorticography.

Journal Article Epilepsy & behavior : E&B · December 2011 The Second International Workshop on Advances in Electrocorticography (ECoG) was convened in San Diego, CA, USA, on November 11-12, 2010. Between this meeting and the inaugural 2009 event, a much clearer picture has been emerging of cortical ECoG physiolog ... Full text Cite

Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo.

Journal Article Nature neuroscience · November 2011 Featured Publication Arrays of electrodes for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, yet are unable to sample large areas of the brain while maintaining high spatial resolution because of the need to individua ... Full text Cite

Data mining neocortical high-frequency oscillations in epilepsy and controls.

Journal Article Brain : a journal of neurology · October 2011 Featured Publication Transient high-frequency (100-500 Hz) oscillations of the local field potential have been studied extensively in human mesial temporal lobe. Previous studies report that both ripple (100-250 Hz) and fast ripple (250-500 Hz) oscillations are increased in th ... Full text Cite

Flexible biomedical devices for mapping cardiac and neural electrophysiology

Conference IEEE International Reliability Physics Symposium Proceedings · June 23, 2011 Clinical in-vivo electrophysiological measurements using standard technologies provide spatial resolution limited by the number of electrodes. Recent strategies demonstrate that high resolution is possible by use of active multiplexing silicon electronics, ... Full text Cite

Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy.

Journal Article Nature materials · April 2011 Featured Publication Developing advanced surgical tools for minimally invasive procedures represents an activity of central importance to improving human health. A key challenge is in establishing biocompatible interfaces between the classes of semiconductor device and sensor ... Full text Cite

Millimeter-scale epileptiform spike patterns and their relationship to seizures.

Conference Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · January 2011 Advances in neural electrode technology are enabling brain recordings with increasingly fine spatial and temporal resolution. We explore spatio-temporal (ST) patterns of local field potential spikes using a new high-density active electrode array with 500 ... Full text Cite

Flexible organic electronics for use in neural sensing.

Conference Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · January 2011 Recent research in brain-machine interfaces and devices to treat neurological disease indicate that important network activity exists at temporal and spatial scales beyond the resolution of existing implantable devices. High density, active electrode array ... Full text Cite

Unsupervised classification of high-frequency oscillations in human neocortical epilepsy and control patients.

Journal Article Journal of neurophysiology · November 2010 Featured Publication High-frequency oscillations (HFOs) have been observed in animal and human intracranial recordings during both normal and aberrant brain states. It has been proposed that the relationship between subclasses of these oscillations can be used to identify epil ... Full text Cite

Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics.

Journal Article Nature materials · June 2010 Featured Publication Electronics that are capable of intimate, non-invasive integration with the soft, curvilinear surfaces of biological tissues offer important opportunities for diagnosing and treating disease and for improving brain/machine interfaces. This article describe ... Full text Cite

A conformal, bio-interfaced class of silicon electronics for mapping cardiac electrophysiology.

Journal Article Science translational medicine · March 2010 Featured Publication In all current implantable medical devices such as pacemakers, deep brain stimulators, and epilepsy treatment devices, each electrode is independently connected to separate control systems. The ability of these devices to sample and stimulate tissues is hi ... Full text Cite

Mining terabytes of submillimeter-resolution ECoG datasets for neurophysiologic biomarkers.

Conference Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · January 2010 Recent research in brain-machine interfaces and devices to treat neurological disease indicate that important network activity exists at temporal and spatial scales beyond the resolution of existing implantable devices. We present innovations in both hardw ... Full text Cite