Scholars@Duke
Jacob Egol

Selected Publications

Topology-driven discovery of transmembrane protein S-palmitoylation.

Journal Article J Biol Chem · March 2025 Protein S-palmitoylation is a reversible lipophilic posttranslational modification regulating diverse signaling pathways. Within transmembrane proteins (TMPs), S-palmitoylation is implicated in conditions from inflammatory disorders to respiratory viral in ... Full text Link to item Cite

mRNA stability fine-tunes gene expression in the developing cortex to control neurogenesis.

Journal Article PLoS Biol · February 2025 RNA abundance is controlled by rates of synthesis and degradation. Although mis-regulation of RNA turnover is linked to neurodevelopmental disorders, how it contributes to cortical development is largely unknown. Here, we discover the landscape of RNA stab ... Full text Link to item Cite

Analysis of Protein Cysteine Acylation Using a Modified Suspension Trap (Acyl-Trap).

Journal Article J Proteome Res · August 2, 2024 Proteins undergo reversible S-acylation via a thioester linkage in vivo. S-palmitoylation, modification by C16:0 fatty acid, is a common S-acylation that mediates critical protein-membrane and protein-protein interactions. The most widely used S-acylation ... Full text Link to item Cite