Jae-Hyun Kim

Journal Article Nature · January 2025 Motor skill repertoire can be stably retained over long periods, but the neural mechanism that underlies stable memory storage remains poorly understood1-8. Moreover, it is unknown how existing motor memories are maintained as new motor skills are continuo ... Full text Link to item Cite

A combinatorial neural code for long-term motor memory.

Preprint · June 5, 2024 Full text Link to item Cite

Adolescent Parvalbumin Expression in the Left Orbitofrontal Cortex Shapes Sociability in Female Mice.

Journal Article The Journal of neuroscience : the official journal of the Society for Neuroscience · March 2023 The adolescent social experience is essential for the maturation of the prefrontal cortex in mammalian species. However, it still needs to be determined which cortical circuits mature with such experience and how it shapes adult social behaviors in a sex-s ... Full text Cite

Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant.

Journal Article Experimental & molecular medicine · February 2023 In binocular animals that exhibit stereoscopic visual responses, the axons of retinal ganglion cells (RGCs) connect to brain areas bilaterally by forming a commissure called the optic chiasm (OC). Ventral anterior homeobox 1 (Vax1) contributes to the forma ... Full text Cite

Gated feedforward inhibition in the frontal cortex releases goal-directed action.

Journal Article Nature neuroscience · October 2021 Cortical circuits process both sensory and motor information in animals performing perceptual tasks. However, it is still unclear how sensory inputs are transformed into motor signals in the cortex to initiate goal-directed actions. In this study, we found ... Full text Cite

Precise Mapping of Single Neurons by Calibrated 3D Reconstruction of Brain Slices Reveals Topographic Projection in Mouse Visual Cortex.

Journal Article Cell reports · May 2020 Recent breakthroughs in neuroanatomical tracing methods have helped unravel complicated neural connectivity in whole-brain tissue at single-cell resolution. However, in most cases, analysis of brain images remains dependent on highly subjective and sample- ... Full text Cite

Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1.

Journal Article Science advances · April 2020 Somatostatin (SST) is a neuropeptide expressed in a major subtype of GABAergic interneurons in the cortex. Despite abundant expression of SST and its receptors, their modulatory function in cortical processing remains unclear. Here, we found that SST appli ... Full text Cite

Multi-wavelength light emitting diode-based disposable optrode array for in vivo optogenetic modulation.

Journal Article Journal of biophotonics · May 2019 We present a light emitting diode (LED)-based optical waveguide array that can optogenetically modulate genetically targeted neurons in the brain. The reusable part of the system consists of control electronics and conventional multi-wavelength LED. The di ... Full text Cite

Function of Selective Neuromodulatory Projections in the Mammalian Cerebral Cortex: Comparison Between Cholinergic and Noradrenergic Systems.

Journal Article Frontiers in neural circuits · January 2018 Cortical processing is dynamically modulated by different neuromodulators. Neuromodulation of the cerebral cortex is crucial for maintaining cognitive brain functions such as perception, attention and learning. However, we do not fully understand how neuro ... Full text Cite

Functional dissection of inhibitory microcircuits in the visual cortex.

Journal Article Neuroscience research · March 2017 Cerebral cortex contains various types of GABAergic neurons exerting local inhibition. Although the number of GABAergic inhibitory neurons is much smaller than glutamatergic excitatory neurons, they show greater diversity in their morphological and physiol ... Full text Cite

Novel four-sided neural probe fabricated by a thermal lamination process of polymer films.

Journal Article Journal of neuroscience methods · February 2017 BackgroundIdeally, neural probes should have channels with a three-dimensional (3-D) configuration to record the activities of 3-D neural circuits. Many types of 3-D neural probes have been developed; however, most of them were designed as an arra ... Full text Cite

A Neural Circuit for Auditory Dominance over Visual Perception.

Journal Article Neuron · February 2017 When conflicts occur during integration of visual and auditory information, one modality often dominates the other, but the underlying neural circuit mechanism remains unclear. Using auditory-visual discrimination tasks for head-fixed mice, we found that a ... Full text Cite

Selectivity of Neuromodulatory Projections from the Basal Forebrain and Locus Ceruleus to Primary Sensory Cortices.

Journal Article The Journal of neuroscience : the official journal of the Society for Neuroscience · May 2016 UnlabelledAcetylcholine and noradrenaline are major neuromodulators that affect sensory processing in the cortex. Modality-specific sensory information is processed in defined areas of the cortex, but it is unclear whether cholinergic neurons in t ... Full text Cite