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James R. Bain

Professor in Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
Duke Box 104775, Durham, NC 27710
300 North Duke Street, Room 48-201, Duke Molecular Physiology Institute, Durham, NC 27701-2047

Current Appointments & Affiliations


Professor in Medicine · 2021 - Present Medicine, Endocrinology, Metabolism, and Nutrition, Medicine
Member of Sarah W. Stedman Nutrition and Metabolism Center · 2002 - Present Sarah Stedman Nutrition & Metabolism Center, Duke Molecular Physiology Institute
Senior Fellow in the Center for the Study of Aging · 2013 - Present Center for the Study of Aging and Human Development, Institutes and Centers

Recent Publications


The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition

Journal Article Current Developments in Nutrition · May 1, 2025 Diet is a complex exposure that affects health across the lifespan. Objective biomarkers that can reliably reflect intake of nutrients, foods, and dietary patterns with sufficient accuracy are an important tool for assessing associations of diet with healt ... Full text Cite

Acute perioperative alterations in metabolism: A pilot study using mass spectrometry-based metabolomics.

Journal Article Surgery · April 2025 OBJECTIVE: To characterize early physiologic stresses imposed by surgery by applying metabolomic analyses to deeply phenotype pre- and postoperative plasma and urine of patients undergoing elective surgical procedures. BACKGROUND: Patients experience perio ... Full text Link to item Cite

Type-2 Diabetes, Pancreatic Amylin, and Neuronal Metabolic Remodeling in Alzheimer's Disease.

Journal Article Mol Nutr Food Res · July 2024 Type-2 diabetes raises the risk for Alzheimer's disease (AD)-type dementia and the conversion from mild cognitive impairment to dementia, yet mechanisms connecting type-2 diabetes to AD remain largely unknown. Amylin, a pancreatic β-cell hormone co-secrete ... Full text Open Access Link to item Cite
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Recent Grants


Fibro/Adipogenic Progenitor Metabolic Reprogramming for Age-Related Muscle Fibrosis

ResearchCo-Mentor · Awarded by National Institutes of Health · 2024 - 2029

Elucidating racial and ethnic differences in functional effects of the vaginal microbiome in ovarian cancer

ResearchAdvisor · Awarded by National Institutes of Health · 2024 - 2027

Biomarkers of Dietary Intake and Exposure Data Coordinating Center

ResearchCo Investigator · Awarded by National Institutes of Health · 2021 - 2026

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Education, Training & Certifications


University of Washington · 2001 Ph.D.