Scholars@Duke
James R. Bain

James R. Bain

Professor Emeritus in Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
Duke Box 104775, Durham, NC 27710
300 North Duke Street, Room 48-201, Duke Molecular Physiology Institute, Durham, NC 27701-2047

Current Duke Appointments & Affiliations

Professor Emeritus in Medicine · 2026 - Present Medicine, Endocrinology, Metabolism, and Nutrition, Medicine
Member of Sarah W. Stedman Nutrition and Metabolism Center · 2002 - Present Sarah Stedman Nutrition & Metabolism Center, Duke Molecular Physiology Institute
Senior Fellow in the Center for the Study of Aging · 2013 - Present Center for the Study of Aging and Human Development, Institutes and Centers

Recent Scholarly Works

Glutamine-driven reductive TCA cycle metabolism supports aged muscle stem cell function via de novo lipogenesis.

Journal article Nat Aging · May 2026 Sarcopenia and the age-related decline in muscular strength and regenerative capacity contribute directly to loss of autonomy, greater risk for hospitalization and healthcare utilization. One contributing cellular phenotype associated with skeletal muscle ... Full text Link to item Cite

20: THE ROLE OF BLOOD-BRAIN BARRIER DYSFUNCTION IN INTENSIVE CARE UNIT DELIRIUM

Conference Critical Care Medicine · March 1, 2026 Introduction: Delirium occurs in ~70% of older ICU patients and is associated with an increased risk of subsequent long-term cognitive impairment. Although evidence from animal models and human plasma biomarkers suggest a role for blood-brain barrier (BBB) ... Full text Cite

Early Markers of Cardiac and Skeletal Muscle Metabolic Derangement in the Apc(min/+) Male Mouse.

Journal article Cancer Rep (Hoboken) · September 2025 BACKGROUND AND AIMS: Cancer cachexia is a metabolic and wasting disease that occurs in up to 80% of cancer patients. Currently, there are no clear diagnostic criteria, its effects are irreversible, and it cannot be treated. Most patients progress undetecte ... Full text Link to item Cite
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Recent Grants

Fibro/Adipogenic Progenitor Metabolic Reprogramming for Age-Related Muscle Fibrosis

ResearchCo-Mentor · Awarded by National Institute on Aging · 2024 - 2029

North Carolina Diabetes Research Center (NCDRC) - Duke site

ResearchInvestigator · Awarded by Wake Forest University Health Sciences · 2020 - 2028

Chronic Stress and Vaginal Fluid Metabolomics Signatures in Ovarian Cancer

ResearchAdvisor · Awarded by National Cancer Institute · 2024 - 2027

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Education

University of Washington · 2001 Ph.D.