James Taylor Herbert

Dr. Herbert is a full-time clinician with practice in critical care medicine and anesthesiology. His primary clinical sites are at Duke University Hospital in the Surgical Intensive Care Unit and Perioperative Services and at Duke Regional Hospital in the Critical Care Unit. In addition to clinical practice, Dr. Herbert has interests in clinical trials research in the areas of airway management, sepsis, and lung injury. Dr. Herbert is also a strong proponent of medical education and takes an active role in medical student, resident, and fellow education.

Current Appointments & Affiliations

Assistant Professor of Anesthesiology · 2021 - Present Anesthesiology, Critical Care Medicine, Anesthesiology

Recent Publications

Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients: The Phase 2 MARBLE Randomized Clinical Trial.

Journal Article JAMA Netw Open · April 1, 2026 IMPORTANCE: The apolipoprotein E (APOE) gene ε4 allele leads to increased Alzheimer disease risk and neuroinflammation and is also believed to play a role in postoperative delirium. However, the safety and feasibility of modulating apoE protein signaling t ... Full text Link to item Cite

Video vs Direct Laryngoscopy for Tracheal Intubation After Cardiac Arrest: A Secondary Analysis of the Direct vs Video Laryngoscope Trial.

Journal Article Chest · May 2025 BACKGROUND: Airway management is a critical component of the care of patients experiencing cardiac arrest, but data from randomized trials on the use of video vs direct laryngoscopy for intubation in the setting of cardiac arrest are limited. Current Ameri ... Full text Link to item Cite

Association Between Neuromuscular Blocking Agents and Outcomes of Emergency Tracheal Intubation: A Secondary Analysis of Randomized Trials.

Journal Article Ann Emerg Med · January 2025 STUDY OBJECTIVE: To examine the association between the neuromuscular blocking agent received (succinylcholine versus rocuronium) and the incidences of successful intubation on the first attempt and severe complications during tracheal intubation of critic ... Full text Link to item Cite

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Education

Duke University, School of Medicine · 2013 M.D.

Duke University · 2013 Ph.D.