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James Emmett Herndon II

Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
Duke Box 2717, Durham, NC 27710
2424 Erwin Road, 8020 Hock Plaza, Durham, NC 27705

Selected Grants


Innate Antiviral Signals for Cancer Immunotherapy

ResearchStatistician · Awarded by National Institutes of Health · 2018 - 2028

ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas

ResearchInvestigator · Awarded by National Institutes of Health · 2022 - 2027

Enhancing the efficacy of Radiation Therapy for brainstem glioma by targeting ATM

ResearchAdvisor · Awarded by National Institutes of Health · 2022 - 2027

Targeting tumor-neural cell interactions to inhibit lung cancer brain metastasis

ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2021 - 2026

Clinical Neuroimmunology of Vaccines in Brain Tumors

ResearchInvestigator · Awarded by National Institutes of Health · 2021 - 2025

Innate Antiviral Signals for Cancer Immunotherapy

ResearchStatistician · Awarded by National Institutes of Health · 2018 - 2028

ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas

ResearchInvestigator · Awarded by National Institutes of Health · 2022 - 2027

Enhancing the efficacy of Radiation Therapy for brainstem glioma by targeting ATM

ResearchAdvisor · Awarded by National Institutes of Health · 2022 - 2027

Targeting tumor-neural cell interactions to inhibit lung cancer brain metastasis

ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2021 - 2026

Clinical Neuroimmunology of Vaccines in Brain Tumors

ResearchInvestigator · Awarded by National Institutes of Health · 2021 - 2025

Synergestic microglial activation and tumor cell killing for improved GBM response

ResearchCo Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2021 - 2025

Genomic and Spatial Expression Analysis of Oligodendroglioma to Identify Novel Therapeutic and Prognostic Targets

ResearchStatistician · Awarded by Doris Duke Charitable Foundation, Inc. · 2022 - 2025

Reviving cancer immune surveillance with CD4 T cell help

ResearchCollaborator · Awarded by National Institutes of Health · 2022 - 2025

Regional Oncolytic Poliovirus Immunotherapy for Breast Cancer

ResearchInvestigator · Awarded by Department of Defense · 2016 - 2024

Reviving cancer immune surveillance with CD4 T cell help

ResearchCo-Mentor · Awarded by National Institutes of Health · 2021 - 2023

Human EGFRvIII-specific BiTE for the treatment of Glioblastoma

ResearchBiostatistician III · Awarded by National Institutes of Health · 2015 - 2023

A Novel Immune Modulating Antibody for the Treatment of Lung Cancer

ResearchBiostatistician · Awarded by Department of Defense · 2019 - 2022

BATF3+ Dendritic Cells for the Treatment of Malignant Gliomas

ResearchCollaborator · Awarded by Department of Defense · 2020 - 2022

The Role of CD155 in Leptomeningeal Dissemination and Oncolytic Virus Susceptibility in the Medulloblastoma Microenvironment

ResearchSignificant Contributor · Awarded by Department of Defense · 2018 - 2022

Is Low Tumor Mutational Burden Predictive of Response to Oncolytic Polio Virus Therapy in Recurrent Glioblastoma?

ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2022

Unraveling the Role of ABL 1 and 2 Drivers of Medulloblastoma Leptomeningeal Metastases

ResearchInvestigator · Awarded by National Institutes of Health · 2020 - 2021

CCL3 as a Developmental Therapeutic to Enhance Brain Tumor Therapy

ResearchStatistician · Awarded by National Institutes of Health · 2016 - 2021

Improving CAR T cell immunotherapy for heterogeneous brain tumors

ResearchCo Investigator · Awarded by University of Florida · 2019 - 2021

Poliovirus-Instigated APC Responses Against BRaf(V600E) for Pediatric Brain Tumor Immunotherapy

ResearchStatistician · Awarded by V Foundation for Cancer Research · 2018 - 2021

BMX-001 as a therapeutic agent for treatment of multiple brain metastases

ResearchPrincipal Investigator · Awarded by BioMimetix JV LLC · 2020 - 2020

Therapeutic Vaccine Targeting CMV Antigens in Glioblastoma

ResearchInvestigator · Awarded by Annias Immunotherapeutics, Inc. · 2015 - 2020

Ph 1/2 Trial for Patients with Newly Diagnosed High Grade Glioma Treated with Concurrent Radiation Therapy, Temozolomide, and BMX-001

Clinical TrialBiostatistician Investigator · Awarded by BioMimetix JV LLC · 2015 - 2020

Lost and Found: The Bone Marrow as Counterproductive Site of T cell Sequestration in GBM

ResearchStatistician · Awarded by Sontag Foundation · 2015 - 2019

Randomized Trial of Optimal Type of Aerobic Training in Breast Cancer

ResearchPrincipal Investigator · Awarded by Memorial Sloan-Kettering Cancer Center · 2015 - 2019

EGFRvIII-targeted Bispecific T cell Engagers for brain tumors

ResearchInvestigator · Awarded by National Institutes of Health · 2013 - 2019

Development of a Therapeutic for Brain Tumor Immunotherapy

ResearchBiostatistician Investigator · Awarded by National Institutes of Health · 2018 - 2019

Systemically administrered EGRFvIII-targeted bispecific antibody as an immunotherapeutic for glioblastoma.

FellowshipCollaborator · Awarded by National Institutes of Health · 2015 - 2019

Brain tumors with regulatory T-cells treated with EGFRvIII-specific T-cells

ResearchInvestigator · Awarded by National Institutes of Health · 2013 - 2018

Brain Tumor Targeting Using Tumor-Specific Neuroimmunology

ResearchBiostatistician · Awarded by National Institutes of Health · 2014 - 2018

A clinically-relevant anti-CD27 agonist antibody as a vaccine adjuvant for brain tumor immunotherapy

FellowshipCollaborator · Awarded by National Institutes of Health · 2016 - 2017

Improving Adherence to Recommended Surveillance in Breast Cancer Survivors

ResearchMentor · Awarded by National Institutes of Health · 2010 - 2015

Adoptive Immunotherapy for GBM During Hematopoietic Recovery from Temozolomide

Clinical TrialStatistician · Awarded by National Institutes of Health · 2009 - 2014

Targeting EGFRvIII in Brain Tumors with Bispecific Antibodies

FellowshipCollaborator · Awarded by National Institutes of Health · 2013 - 2014

(PQA5) 'Dose and Mechanisms of Exercise in Breast Cancer Prevention'

ResearchCo Investigator · Awarded by National Institutes of Health · 2013 - 2014

Aerobic Training During or After Adjuvant Therapy: A Randomized Trial

ResearchCo Investigator · Awarded by National Institutes of Health · 2012 - 2014

Phase II Trial of Aerobic Training in Metastatic Breast Cancer

ResearchBiostatistician Investigator · Awarded by National Institutes of Health · 2010 - 2014

Randomized Trial of Optimal Type of Aerobic Training in Breast Cancer

ResearchCo Investigator · Awarded by National Institutes of Health · 2010 - 2014

Modulation of the blood-tumor barrier through targeted suppression of claudin 5

ResearchCollaborator · Awarded by National Institutes of Health · 2011 - 2013

Reversal of CMV-specific immune deficits in patients with glioblastoma

Clinical TrialBiostatistician · Awarded by National Institutes of Health · 2009 - 2013

Brain Tumors - Immunological and Biological Studies

ResearchInvestigator · Awarded by National Institutes of Health · 2001 - 2013

Neuroimmunology of Vaccines in Adoptive T-cell Therapy for Brain Tumor

ResearchBiostatistician · Awarded by National Institutes of Health · 2010 - 2012

Pre-clinical Translation of Regulatory T-cell Inhibition in Brain Tumors

ResearchBiostatistician · Awarded by National Institutes of Health · 2010 - 2012

The Role of OTX2 in Molecular Pathogenesis of Medulloblastoma

ResearchCo Investigator · Awarded by National Institutes of Health · 2006 - 2012

Gene Targeted Therapy of Brain Tumors

ResearchBiostatistician · Awarded by National Institutes of Health · 2009 - 2012

Prospective Validation of Genomic Signatures of Chemosensitivity in NSCLC

ResearchInvestigator · Awarded by National Institutes of Health · 2009 - 2010

Discovery of Biomarkers for Lung Cancer Metastasis

ResearchStatistician · Awarded by National Institutes of Health · 2005 - 2010

Effect on IL-2R Antibody on Regulatory T-cells in Patients with Malignant Gliomas

Clinical TrialStatistician · Awarded by National Institutes of Health · 2008 - 2009

Palliative Oxygen for the Relief of Breathlessness

ResearchSenior Statistician · Awarded by National Institutes of Health · 2006 - 2009

Serum Biomarkers for Early Diagnosis of NSCLC

ResearchStatistician · Awarded by Johns Hopkins University · 2007 - 2009

Stem Cell-Like Glioma Cells in Angiogenesis

ResearchConsultant · Awarded by National Institutes of Health · 2008 - 2009

DNA Methylation and GSTP1 Gene Regulation in Gliomas

ResearchCo Investigator · Awarded by National Institutes of Health · 2002 - 2008

Phase I/II Trial of ZD1839 and Celecoxib in Ex-Smokers

ResearchCo Investigator · Awarded by National Institutes of Health · 2002 - 2007

Measurement of Hypoxia in Non-Small Cell Lung Carcinoma

ResearchStatistician · Awarded by National Institutes of Health · 2002 - 2006

ACOSOG-Statistics and Data Coordinating Center

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2005

ZD1839 Therapy of Glioblastoma Multiforme

ResearchCollaborator · Awarded by National Institutes of Health · 2001 - 2003

Using Plasma TGFB1 Levels to Escalate Radiotherapy Doses

Clinical TrialCo Investigator · Awarded by National Institutes of Health · 2000 - 2003

Src On Primary And Matastatic Tumors Of The Cns

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1994 - 1999

Src On Primary And Metastatic Tumors Of The Cns

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1997 - 1999

Comprehensive Cancer Center Core Support Grant

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1976 - 1998

Cancer Center Core Support Grant

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1976 - 1998

Cancer And Leukemia Group B - Statistical Center

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1994 - 1998

Cancer And Leukemia Group B Statistical Center

Clinical TrialCo-Principal Investigator · Awarded by National Institutes of Health · 1982 - 1998

Src On Malignant Human Gliomas And Medulloblastomas

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1992 - 1994

Comprehensive Cancer Center Core Support Grant

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1992 - 1993

Cancer And Leukemia Group B Statistical Center

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1992 - 1993