Overview
My primary clinical and research focus revolves around women with breast cancer. Specifically, I am interested in studying breast cancer subtype specific (luminal, basal) radiation response in human breast tumors and utilizing that information to design biologically based radiotherapy trials.
Current Appointments & Affiliations
Adjunct Associate Professor in the Department of Radiation Oncology
·
2018 - Present
Radiation Oncology,
Clinical Science Departments
Recent Publications
Pharmacokinetic Drug-Drug Interaction Studies Between Trilaciclib and Midazolam, Metformin, Rifampin, Itraconazole, and Topotecan in Healthy Volunteers and Patients with Extensive-Stage Small-Cell Lung Cancer.
Journal Article Clin Drug Investig · August 2022 BACKGROUND AND OBJECTIVE: Trilaciclib is a cyclin-dependent kinase 4/6 inhibitor indicated to decrease the incidence of chemotherapy-induced myelosuppression in patients with extensive-stage small-cell lung cancer. Trilaciclib is a substrate and time-depen ... Full text Link to item CiteTrilaciclib Prior to Chemotherapy in Patients with Metastatic Triple-Negative Breast Cancer: Final Efficacy and Subgroup Analysis from a Randomized Phase II Study.
Journal Article Clin Cancer Res · February 15, 2022 PURPOSE: We report final antitumor efficacy results from a phase II study of trilaciclib, an intravenous cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, administered prior to gemcitabine plus carboplatin (GCb) in patients with metastatic triple-negative br ... Full text Link to item CiteExploratory composite endpoint demonstrates benefit of trilaciclib across multiple clinically meaningful components of myeloprotection in patients with small cell lung cancer.
Journal Article Int J Cancer · October 1, 2021 Chemotherapy-induced myelosuppression is an acute, dose-limiting toxicity of chemotherapy regimens used in the treatment of extensive-stage small cell lung cancer (ES-SCLC). Trilaciclib protects haematopoietic stem and progenitor cells from chemotherapy-in ... Full text Link to item CiteRecent Grants
Preoperative Breast Radiotherapy: A Tool to Provide Individualized and Biologically-Based Radiation Therapy
ResearchPrincipal Investigator · Awarded by Gateway for Cancer Research · 2015 - 2025View All Grants
Education, Training & Certifications
Wake Forest University ·
2001
M.D.