Janet Knight Horton | Scholars@Duke

Janet Knight Horton
Adjunct Associate Professor in the Department of Radiation Oncology

My primary clinical and research focus revolves around women with breast cancer. Specifically, I am interested in studying breast cancer subtype specific (luminal, basal) radiation response in human breast tumors and utilizing that information to design biologically based radiotherapy trials.

Current Appointments & Affiliations

Adjunct Associate Professor in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2018

Contact Information

201 Trent Drive, 05151A Morris Building, Box 3085, Durham, NC 27710
Department of Radiation Oncolo, Box 3085, Durham, NC 27710
(919) 668-5213

Background
Education, Training, & Certifications
- M.D., Wake Forest University 2001
Duke Appointment History
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013 - 2019
- Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2014 - 2018
- Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2008 - 2014
Research
Selected Grants
- Preoperative Breast Radiotherapy: A Tool to Provide Individualized and Biologically-Based Radiation Therapy awarded by Gateway for Cancer Research 2015 - 2021
External Relationships
- G1 Therapeutics, Inc.
- Wake Forest University School of Medicine
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Gay, Hiram A., Roberto Santiago, Betty Gil, Carlos Remedios, Pedro J. Montes, Javier López-Araujo, Carlos M. Chévere, et al. “Lessons Learned From Hurricane Maria in Puerto Rico: Practical Measures to Mitigate the Impact of a Catastrophic Natural Disaster on Radiation Oncology Patients.” Pract Radiat Oncol 9, no. 5 (September 2019): 305–21. https://doi.org/10.1016/j.prro.2019.03.007.
    Full Text Link to Item
  - Blitzblau, Rachel C., and Janet K. Horton. “First, Do No Harm.” Int J Radiat Oncol Biol Phys 103, no. 2 (February 1, 2019): 295–96. https://doi.org/10.1016/j.ijrobp.2018.04.029.
    Full Text Link to Item
  - Charaghvandi, K. R., T. Van’t Westeinde, S. Yoo, A. C. Houweling, A. Rodrigues, H. M. Verkooijen, M. E. P. Philippens, B. van Asselen, J. K. Horton, and H. J. G. D. van den Bongard. “Single dose partial breast irradiation using an MRI linear accelerator in the supine and prone treatment position.” Clin Transl Radiat Oncol 14 (January 2019): 1–7. https://doi.org/10.1016/j.ctro.2018.09.001.
    Full Text Link to Item
  - Sheng, Yang, Taoran Li, Sua Yoo, Fang-Fang Yin, Rachel Blitzblau, Janet K. Horton, Yaorong Ge, and Q Jackie Wu. “Automatic Planning of Whole Breast Radiation Therapy Using Machine Learning Models.” Front Oncol 9 (2019): 750. https://doi.org/10.3389/fonc.2019.00750.
    Full Text Open Access Copy Link to Item
  - Natarajan, Brahma, Daphna Spiegel, Elizabeth M. Nichols, Steven Feigenberg, Rachel Blitzblau, Gloria Broadwater, Eileen A. Duffy, Jay A. Baker, and Janet K. Horton. “Findings on Surveillance Imaging After Preoperative Partial Breast Irradiation for Early Stage Breast Cancer.” Int J Radiat Oncol Biol Phys 102, no. 4 (November 15, 2018): 1374–81. https://doi.org/10.1016/j.ijrobp.2018.05.059.
    Full Text Link to Item
  - Belkacemi, Yazid, Benjamin D. Smith, and Janet K. Horton. “Regional Nodal Irradiation in the Modern Era of Breast Cancer Management.” Int J Radiat Oncol Biol Phys 101, no. 2 (June 1, 2018): 241–43. https://doi.org/10.1016/j.ijrobp.2017.10.036.
    Full Text Link to Item
  - Jagsi, Reshma, Kent A. Griffith, Jennifer R. Bellon, Wendy A. Woodward, Janet K. Horton, Alice Ho, Felix Y. Feng, et al. “Concurrent Veliparib With Chest Wall and Nodal Radiotherapy in Patients With Inflammatory or Locoregionally Recurrent Breast Cancer: The TBCRC 024 Phase I Multicenter Study.” J Clin Oncol 36, no. 13 (May 1, 2018): 1317–22. https://doi.org/10.1200/JCO.2017.77.2665.
    Full Text Link to Item
  - Rahal, Omar M., Adam R. Wolfe, Pijus K. Mandal, Richard Larson, Sanda Tin, Cristina Jimenez, Dadong Zhang, et al. “Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer.” Int J Radiat Oncol Biol Phys 100, no. 4 (March 15, 2018): 1034–43. https://doi.org/10.1016/j.ijrobp.2017.11.043.
    Full Text Link to Item
  - Ryser, Marc D., Janet K. Horton, and E Shelley Hwang. “How Low Can We Go-and Should We? Risk Reduction for Minimal-Volume DCIS.” Ann Surg Oncol 25, no. 2 (February 2018): 354–55. https://doi.org/10.1245/s10434-017-6128-4.
    Full Text Link to Item
  - Horton, Janet K., Reshma Jagsi, Wendy A. Woodward, and Alice Ho. “Breast Cancer Biology: Clinical Implications for Breast Radiation Therapy.” Int J Radiat Oncol Biol Phys 100, no. 1 (January 1, 2018): 23–37. https://doi.org/10.1016/j.ijrobp.2017.08.025.
    Full Text Link to Item
  - Charaghvandi, Ramona K., Sua Yoo, Bram van Asselen, Anna Rodrigues, Desirée H. J. G. van den Bongard, and Janet K. Horton. “Treatment constraints for single dose external beam preoperative partial breast irradiation in early-stage breast cancer.” Clin Transl Radiat Oncol 6 (October 2017): 7–14. https://doi.org/10.1016/j.ctro.2017.06.003.
    Full Text Link to Item
  - Horton, Janet K. “Postmastectomy Conundrum.” Int J Radiat Oncol Biol Phys 98, no. 5 (August 1, 2017): 976. https://doi.org/10.1016/j.ijrobp.2017.04.013.
    Full Text Link to Item
  - Lee, Chen-Ting, Yingchun Zhou, Kingshuk Roy-Choudhury, Sharareh Siamakpour-Reihani, Kenneth Young, Peter Hoang, John P. Kirkpatrick, Jen-Tsan Chi, Mark W. Dewhirst, and Janet K. Horton. “Subtype-Specific Radiation Response and Therapeutic Effect of FAS Death Receptor Modulation in Human Breast Cancer.” Radiat Res 188, no. 2 (August 2017): 169–80. https://doi.org/10.1667/RR14664.1.
    Full Text Link to Item
  - Greenup, Rachel A., Rachel C. Blitzblau, Kevin L. Houck, Julie Ann Sosa, Janet Horton, Jeffrey M. Peppercorn, Alphonse G. Taghian, Barbara L. Smith, and E Shelley Hwang. “Cost Implications of an Evidence-Based Approach to Radiation Treatment After Lumpectomy for Early-Stage Breast Cancer.” J Oncol Pract 13, no. 4 (April 2017): e283–90. https://doi.org/10.1200/JOP.2016.016683.
    Full Text Link to Item
  - Morrow, Monica, Kimberly J. Van Zee, Lawrence J. Solin, Nehmat Houssami, Mariana Chavez-MacGregor, Jay R. Harris, Janet Horton, et al. “Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma In Situ.” J Clin Oncol 34, no. 33 (November 20, 2016): 4040–46. https://doi.org/10.1200/JCO.2016.68.3573.
    Full Text Link to Item
  - Morrow, Monica, Kimberly J. Van Zee, Lawrence J. Solin, Nehmat Houssami, Mariana Chavez-MacGregor, Jay R. Harris, Janet Horton, et al. “Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery with Whole-Breast Irradiation in Ductal Carcinoma In Situ.” Ann Surg Oncol 23, no. 12 (November 2016): 3801–10. https://doi.org/10.1245/s10434-016-5449-z.
    Full Text Link to Item
  - Sheng, Y., T. Li, S. Yoo, F. F. Yin, R. C. Blitzblau, J. K. Horton, M. Palta, C. A. Hahn, Y. Ge, and Q. R. Wu. “Development of an Ultra-Fast, High-Quality Whole-Breast Radiation Therapy Treatment Planning System.” Int J Radiat Oncol Biol Phys 96, no. 2S (October 1, 2016): S228. https://doi.org/10.1016/j.ijrobp.2016.06.566.
    Full Text Link to Item
  - Spiegel, D., P. K. Marcom, B. Peterson, J. Force, L. Howie, M. Palta, R. C. Blitzblau, and J. K. Horton. “Acute Toxicity in Patients With HER2-Positive Breast Cancer Treated With Adjuvant Radiation Therapy and Concurrent Trastuzumab and Pertuzumab.” Int J Radiat Oncol Biol Phys 96, no. 2S (October 1, 2016): E9–10. https://doi.org/10.1016/j.ijrobp.2016.06.619.
    Full Text Link to Item
  - Wang, C., J. K. Horton, F. F. Yin, E. Subashi, and Z. Chang. “Early-Stage Breast Radiation Therapy Assessment Using Transcytolemmal Water Exchange Analysis of DCE-Magnetic Resonance Imaging: Initial Results.” Int J Radiat Oncol Biol Phys 96, no. 2S (October 1, 2016): E617. https://doi.org/10.1016/j.ijrobp.2016.06.2176.
    Full Text Link to Item
  - Wang, Chunhao, Janet K. Horton, Fang-Fang Yin, and Zheng Chang. “Assessment of Treatment Response With Diffusion-Weighted MRI and Dynamic Contrast-Enhanced MRI in Patients With Early-Stage Breast Cancer Treated With Single-Dose Preoperative Radiotherapy: Initial Results.” Technol Cancer Res Treat 15, no. 5 (October 2016): 651–60. https://doi.org/10.1177/1533034615593191.
    Full Text Link to Item
  - Yoo, S., J. K. Horton, F. F. Yin, and R. C. Blitzblau. “Dosimetric Effect of the Breast Board and Couch Top for Whole-Breast Radiation Therapy in the Prone Position.” Int J Radiat Oncol Biol Phys 96, no. 2S (October 1, 2016): E46–47. https://doi.org/10.1016/j.ijrobp.2016.06.710.
    Full Text Link to Item
  - Morrow, Monica, Kimberly J. Van Zee, Lawrence J. Solin, Nehmat Houssami, Mariana Chavez-MacGregor, Jay R. Harris, Janet Horton, et al. “Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma in Situ.” Pract Radiat Oncol 6, no. 5 (September 2016): 287–95. https://doi.org/10.1016/j.prro.2016.06.011.
    Full Text Link to Item
  - Horton, J. K. “Integration of a Radiosensitivity Molecular Signature into the Assessment of Local Recurrence Risk in Breast Cancer.” Breast Diseases 27, no. 1 (January 1, 2016): 76–77. https://doi.org/10.1016/j.breastdis.2016.01.021.
    Full Text
  - Kent, Collin, Janet Horton, Rachel Blitzblau, and Bridget F. Koontz. “Whose Disease Will Recur After Mastectomy for Early Stage, Node-Negative Breast Cancer? A Systematic Review.” Clin Breast Cancer 15, no. 6 (December 2015): 403–12. https://doi.org/10.1016/j.clbc.2015.06.008.
    Full Text Link to Item
  - Horton, Janet K., Sharareh Siamakpour-Reihani, Chen-Ting Lee, Ying Zhou, Wei Chen, Joseph Geradts, Diane R. Fels, et al. “FAS Death Receptor: A Breast Cancer Subtype-Specific Radiation Response Biomarker and Potential Therapeutic Target.” Radiat Res 184, no. 5 (November 2015): 456–69. https://doi.org/10.1667/RR14089.1.
    Full Text Link to Item
  - Siamakpour-Reihani, Sharareh, Kouros Owzar, Chen Jiang, Taylor Turner, Yiwen Deng, Sarah M. Bean, Janet K. Horton, et al. “Prognostic significance of differential expression of angiogenic genes in women with high-grade serous ovarian carcinoma.” Gynecol Oncol 139, no. 1 (October 2015): 23–29. https://doi.org/10.1016/j.ygyno.2015.08.001.
    Full Text Link to Item
  - Blitzblau, Rachel C., Ritu Arya, Sua Yoo, Jay A. Baker, Zheng Chang, Manisha Palta, Eileen Duffy, and Janet K. Horton. “A phase 1 trial of preoperative partial breast radiation therapy: Patient selection, target delineation, and dose delivery.” Pract Radiat Oncol 5, no. 5 (September 2015): e513–20. https://doi.org/10.1016/j.prro.2015.02.002.
    Full Text Link to Item
  - Horton, Janet K., Rachel C. Blitzblau, Sua Yoo, Joseph Geradts, Zheng Chang, Jay A. Baker, Gregory S. Georgiade, et al. “Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers.” Int J Radiat Oncol Biol Phys 92, no. 4 (July 15, 2015): 846–55. https://doi.org/10.1016/j.ijrobp.2015.03.007.
    Full Text Link to Item
  - Arya, Ritu, Sharareh Siamakpour-Reihani, Manisha Palta, Lisa Massa, Gloria Broadwater, Rachel C. Blitzblau, and Janet K. Horton. “Exercise behavior and patient-reported outcomes in women with early breast cancer receiving locoregional radiation therapy.” Pract Radiat Oncol 5, no. 4 (July 2015): e275–81. https://doi.org/10.1016/j.prro.2015.01.003.
    Full Text Link to Item
  - Siamakpour-Reihani, Sharareh, Kouros Owzar, Chen Jiang, Peter M. Scarbrough, Oana I. Craciunescu, Janet K. Horton, Holly K. Dressman, Kimberly L. Blackwell, and Mark W. Dewhirst. “Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival.” Int J Hyperthermia 31, no. 4 (June 2015): 386–95. https://doi.org/10.3109/02656736.2015.1016557.
    Full Text Link to Item
  - Yoo, Sua, Rachel Blitzblau, Fang-Fang Yin, and Janet K. Horton. “Dosimetric comparison of preoperative single-fraction partial breast radiotherapy techniques: 3D CRT, noncoplanar IMRT, coplanar IMRT, and VMAT.” J Appl Clin Med Phys 16, no. 1 (January 8, 2015): 5126. https://doi.org/10.1120/jacmp.v16i1.5126.
    Full Text Link to Item
  - Horton, J. K. “First results of the preoperative accelerated partial breast irradiation (PAPBI) trial.” Breast Diseases 26, no. 4 (January 1, 2015): 341–42. https://doi.org/10.1016/j.breastdis.2015.10.014.
    Full Text
  - Horton, J. K., and J. R. Bellon. “Oncology scandquality of life and patient perspectives during breast radiation therapy.” International Journal of Radiation Oncology Biology Physics 91, no. 2 (January 1, 2015): 249–51. https://doi.org/10.1016/j.ijrobp.2014.08.007.
    Full Text
  - McGuire, Kandace P., E Shelley Hwang, Alan Cantor, Mehra Golshan, Funda Meric-Bernstam, Janet K. Horton, Rita Nanda, et al. “Surgical patterns of care in patients with invasive breast cancer treated with neoadjuvant systemic therapy and breast magnetic resonance imaging: results of a secondary analysis of TBCRC 017.” Ann Surg Oncol 22, no. 1 (January 2015): 75–81. https://doi.org/10.1245/s10434-014-3948-3.
    Full Text Link to Item
  - Yoo, S., R. Blitzblau, F. F. Yin, and J. K. Horton. “Dosimetric comparison of preoperative single-fraction partial breast radiotherapy techniques: 3D CRT, noncoplanar IMRT, coplanar IMRT, and VMAT.” Journal of Applied Clinical Medical Physics 16, no. 1 (January 1, 2015): 183–91.
  - Horton, Janet K., Mark W. Dewhirst, Sharareh Siamakpour-Reihani, Yingchun Zhou, Joseph Geradts, Jen-Tsan Ashley Chi, and Wei Chen. “Changes in Gene Expression After Radiation in Human Breast Cancers: A Guide to Predicting and Modulating Radiation Response.” Journal of Womens Health 23, no. 10 (October 1, 2014): 861–861.
    Link to Item
  - Moran, Meena S., Stuart J. Schnitt, Armando E. Giuliano, Jay R. Harris, Seema A. Khan, Janet Horton, Suzanne Klimberg, et al. “Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer.” J Clin Oncol 32, no. 14 (May 10, 2014): 1507–15. https://doi.org/10.1200/JCO.2013.53.3935.
    Full Text Link to Item
  - Horton, J. K. “Prospective multicenter trial evaluating balloon-catheter partial-breast irradiation for ductal carcinoma in situ.” Breast Diseases 25, no. 1 (March 17, 2014): 80–81. https://doi.org/10.1016/j.breastdis.2014.01.015.
    Full Text
  - Moran, Meena S., Stuart J. Schnitt, Armando E. Giuliano, Jay R. Harris, Seema A. Khan, Janet Horton, Suzanne Klimberg, et al. “Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer.” Int J Radiat Oncol Biol Phys 88, no. 3 (March 1, 2014): 553–64. https://doi.org/10.1016/j.ijrobp.2013.11.012.
    Full Text Link to Item
  - Moran, Meena S., Stuart J. Schnitt, Armando E. Giuliano, Jay R. Harris, Seema A. Khan, Janet Horton, Suzanne Klimberg, et al. “Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer.” Ann Surg Oncol 21, no. 3 (March 2014): 704–16. https://doi.org/10.1245/s10434-014-3481-4.
    Full Text Link to Item
  - Horton, J. K. “Effect of local therapy on locoregional recurrence in postmenopausal women with breast cancer in the Tamoxifen Exemestane Adjuvant Multinational (TEAM) trial: Van Hezewijk M, Bastiaannet E, Putter H, et al (Leiden Univ Med Ctr, the Netherlands; Et al) Radiother Oncol 108:190-196, 2013.” Breast Diseases 25, no. 2 (January 1, 2014): 179–80. https://doi.org/10.1016/j.breastdis.2014.04.037.
    Full Text
  - Moran, M. S., S. J. Schnitt, A. E. Giuliano, J. R. Harris, S. A. Khan, J. Horton, S. Klimberg, et al. “Society of surgical oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages i and II invasive breast cancer.” Annals of Surgical Oncology 21, no. 3 (2014): 704–16.
  - Qiu, Jian-Jian, Zheng Chang, Janet K. Horton, Qing-Rong Jackie Wu, Sua Yoo, and Fang-Fang Yin. “Dosimetric comparison of 3D conformal, IMRT, and V-MAT techniques for accelerated partial-breast irradiation (APBI).” Med Dosim 39, no. 2 (2014): 152–58. https://doi.org/10.1016/j.meddos.2013.12.001.
    Full Text Link to Item
  - Blitzblau, Rachel C., and Janet K. Horton. “Treatment planning technique in patients receiving postmastectomy radiation therapy.” Pract Radiat Oncol 3, no. 4 (October 2013): 241–48. https://doi.org/10.1016/j.prro.2012.09.004.
    Full Text Link to Item
  - Horton, Janet K., Jen-Tsan Ashley Chi, Jeff Groth, Yingchun Zhou, Chen-Ting Lee, and Joseph Geradts. “Up-regulation of Fas Expression in Human Breast Carcinomas Treated With Preoperative Radiation.” Journal of Womens Health 22, no. 10 (October 1, 2013): 890–890.
    Link to Item
  - Blitzblau, Rachel C., and Janet K. Horton. “Radiotherapy after mastectomy.” Surg Oncol Clin N Am 22, no. 3 (July 2013): 563–77. https://doi.org/10.1016/j.soc.2013.02.012.
    Full Text Link to Item
  - De Los Santos, Jennifer F., Alan Cantor, Keith D. Amos, Andres Forero, Mehra Golshan, Janet K. Horton, Clifford A. Hudis, et al. “Magnetic resonance imaging as a predictor of pathologic response in patients treated with neoadjuvant systemic treatment for operable breast cancer. Translational Breast Cancer Research Consortium trial 017.” Cancer 119, no. 10 (May 15, 2013): 1776–83. https://doi.org/10.1002/cncr.27995.
    Full Text Link to Item
  - Horton, J. K., and R. Jagsi. “Oncology scan - Breast cancers.” International Journal of Radiation Oncology Biology Physics 85, no. 5 (April 1, 2013): 1151–52. https://doi.org/10.1016/j.ijrobp.2013.01.007.
    Full Text
  - Lyman, Gary H., Jay Baker, Joseph Geradts, Janet Horton, Gretchen Kimmick, Jeffrey Peppercorn, Scott Pruitt, Randall P. Scheri, and E Shelley Hwang. “Multidisciplinary care of patients with early-stage breast cancer.” Surg Oncol Clin N Am 22, no. 2 (April 2013): 299–317. https://doi.org/10.1016/j.soc.2012.12.005.
    Full Text Link to Item
  - Horton, Janet K., Diane R. Fels, Hsiu-Ni Kung, Yingchun Zhou, Kathleen Ashcraft, Mark W. Dewhirst, and Jen-Tsan Ashley Chi. “Differential Activation of Cell Death Pathways After Ionizing Radiation in Luminal and Basal Breast Cancer Cell Lines.” Journal of Womens Health 21, no. 10 (October 1, 2012): 992–992.
    Link to Item
  - Cuneo, Kyle C., Rajesh C. Dash, Lee G. Wilke, Janet K. Horton, and Bridget F. Koontz. “Risk of invasive breast cancer and ductal carcinoma in situ in women with atypical papillary lesions of the breast.” Breast J 18, no. 5 (September 2012): 475–78. https://doi.org/10.1111/j.1524-4741.2012.01276.x.
    Full Text Link to Item
  - Moran, Meena S., and Janet K. Horton. “Oncology Scan – Breast Cancer.” International Journal of Radiation Oncology*Biology*Physics 84, no. 1 (September 2012): 1–3. https://doi.org/10.1016/s0360-3016(12)00929-7.
    Full Text
  - Yoo, Sua, Qiuwen Wu, Jennifer O’Daniel, Janet Horton, and Fang-Fang Yin. “Comparison of 3D conformal breast radiation treatment plans using the anisotropic analytical algorithm and pencil beam convolution algorithm.” Radiother Oncol 103, no. 2 (May 2012): 172–77. https://doi.org/10.1016/j.radonc.2012.01.010.
    Full Text Link to Item
  - Blitzblau, R. C., and J. K. Horton. “Evaluation of single nucleotide polymorphisms (SNPs) in the p53 binding protein 1 (TP53BP1) gene in breast cancer patients treated with breast-conserving surgery and whole-breast irradiation (BCS + RT).” Breast Diseases 23, no. 1 (March 7, 2012): 44–45. https://doi.org/10.1016/j.breastdis.2012.01.001.
    Full Text
  - Betof, A. S., Z. N. Rabbani, M. E. Hardee, S. J. Kim, G. Broadwater, R. C. Bentley, S. A. Snyder, et al. “Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification.” Br J Cancer 106, no. 5 (February 28, 2012): 916–22. https://doi.org/10.1038/bjc.2012.32.
    Full Text Link to Item
  - Kimple, Randall J., Janet K. Horton, Chad A. Livasy, Janiel M. Shields, Julia A. Lawrence, Wingkeung M. Chiu, Anastasia Ivanova, et al. “Phase I study and biomarker analysis of lapatinib and concurrent radiation for locally advanced breast cancer.” Oncologist 17, no. 12 (2012): 1496–1503. https://doi.org/10.1634/theoncologist.2012-0256.
    Full Text Link to Item
  - Palta, Manisha, Sua Yoo, Justus D. Adamson, Leonard R. Prosnitz, and Janet K. Horton. “Preoperative single fraction partial breast radiotherapy for early-stage breast cancer.” Int J Radiat Oncol Biol Phys 82, no. 1 (January 1, 2012): 37–42. https://doi.org/10.1016/j.ijrobp.2010.09.041.
    Full Text Link to Item
  - Horton, J. K., D. R. Fels, J. A. Chi, H. Kung, J. P. Kirkpatrick, and M. Dewhirst. “Protein Pathway Activation after Ionizing Radiation in Luminal and Basal Breast Cancer Cell Lines.” International Journal of Radiation Oncology*Biology*Physics 81, no. 2 (October 2011): S160–61. https://doi.org/10.1016/j.ijrobp.2011.06.1658.
    Full Text
  - Horton, Janet K., Diane R. Fels, Hsiu-Ni Kung, Mark W. Dewhirst, and Jen-Tsan Ashley Chi. “Gene Expression Response of Luminal and Basal Breast Cancer Cell Lines to Ionizing Radiation.” Journal of Womens Health 20, no. 10 (October 1, 2011): 1404–5.
    Link to Item
  - Horton, Janet K., John F. Gleason, Heidi D. Klepin, Scott Isom, Daniel B. Fried, and Ann M. Geiger. “Age-related disparities in the use of radiotherapy for treatment of localized soft tissue sarcoma.” Cancer 117, no. 17 (September 1, 2011): 4033–40. https://doi.org/10.1002/cncr.25996.
    Full Text Link to Item
  - Horton, J. K. “Five-year analysis of treatment efficacy and cosmesis by the American Society of Breast Surgeons MammoSite breast brachytherapy registry trial in patients treated with accelerated partial breast irradiation.” Breast Diseases 22, no. 3 (August 30, 2011): 299–300. https://doi.org/10.1016/j.breastdis.2011.06.040.
    Full Text
  - Palta, M., and J. K. Horton. “In response to Drs. Kim and Shaitelman.” International Journal of Radiation Oncology Biology Physics 80, no. 1 (May 1, 2011): 315. https://doi.org/10.1016/j.ijrobp.2010.12.036.
    Full Text
  - Shah, Mira M., Janet K. Horton, Sua Yoo, Jessica L. Hubbs, Senem Demirci, Kim L. Light, Kathy Temple, Michael Patrone, and Lawrence B. Marks. “A comparison of clinical and dosimetric outcomes in patients receiving partial breast irradiation with photon-only versus mixed photon/electron treatment plans.” Med Dosim 36, no. 4 (2011): 423–28. https://doi.org/10.1016/j.meddos.2010.10.004.
    Full Text Link to Item
  - Qiu, Jian-Jian, Zheng Chang, Q Jackie Wu, Sua Yoo, Janet Horton, and Fang-Fang Yin. “Impact of volumetric modulated arc therapy technique on treatment with partial breast irradiation.” Int J Radiat Oncol Biol Phys 78, no. 1 (September 1, 2010): 288–96. https://doi.org/10.1016/j.ijrobp.2009.10.036.
    Full Text Link to Item
  - Horton, Janet K., Jan Halle, Madlyn Ferraro, Lisa Carey, Dominic T. Moore, David Ollila, and Carolyn I. Sartor. “Radiosensitization of chemotherapy-refractory, locally advanced or locally recurrent breast cancer with trastuzumab: a phase II trial.” Int J Radiat Oncol Biol Phys 76, no. 4 (March 15, 2010): 998–1004. https://doi.org/10.1016/j.ijrobp.2009.03.027.
    Full Text Link to Item
  - Prosnitz, Leonard R., Janet Horton, and Paul E. Wallner. “Accelerated partial breast irradiation: caution and concern from an ASTRO task force.” Int J Radiat Oncol Biol Phys 74, no. 4 (July 15, 2009): 981–84. https://doi.org/10.1016/j.ijrobp.2009.03.046.
    Full Text Link to Item
  - Godat, Laura N., Janet K. Horton, Perry Shen, John H. Stewart, Stacy Wentworth, and Edward A. Levine. “Recurrence after mastectomy for ductal carcinoma in situ.” Am Surg 75, no. 7 (July 2009): 592–95.
    Link to Item
  - Lally, Brian E., Ann M. Geiger, James J. Urbanic, Jerome M. Butler, Stacy Wentworth, Michael C. Perry, Lynn D. Wilson, et al. “Trends in the outcomes for patients with limited stage small cell lung cancer: An analysis of the Surveillance, Epidemiology, and End Results database.” Lung Cancer 64, no. 2 (May 2009): 226–31. https://doi.org/10.1016/j.lungcan.2008.08.010.
    Full Text Link to Item
  - Horton, Janet K., Jan S. Halle, Sha X. Chang, and Carolyn I. Sartor. “Comparison of three concomitant boost techniques for early-stage breast cancer.” Int J Radiat Oncol Biol Phys 64, no. 1 (January 1, 2006): 168–75. https://doi.org/10.1016/j.ijrobp.2005.07.004.
    Full Text Link to Item
  - Horton, Janet K., and Joel E. Tepper. “Staging of colorectal cancer: past, present, and future.” Clin Colorectal Cancer 4, no. 5 (January 2005): 302–12. https://doi.org/10.3816/ccc.2005.n.002.
    Full Text Link to Item
  - Horton, J. K. “Hospice. Care when there is no cure.” N C Med J 62, no. 2 (March 2001): 86–90.
    Link to Item
- Book Sections
  - Mowery, Y. M., C. X. Yu, and J. K. Horton. “Preoperative partial breast.” In Short Course Breast Radiotherapy: A Comprehensive Review of Hypofractionation, Partial Breast, and Intra-Operative Irradiation, 415–40, 2015. https://doi.org/10.1007/978-3-319-24388-7_27.
    Full Text
- Conference Papers
  - Adamson, J., Z. Chang, J. Cai, M. Palta, J. K. Horton, F. F. Yin, and R. Blitzblau. “Induction of Gradual Changes in Blood Oxygen Levels in Post Lumpectomy Breast Tissue With Breath Holding: Results of a Pilot Study.” In International Journal of Radiation Oncology*Biology*Physics, 93:E30–E30. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.619.
    Full Text
  - Horton, J. K., J. A. Baker, R. Blitzblau, G. S. Georgiade, E. S. Hwang, E. A. Duffy, M. Morgan, et al. “Preoperative Partial Breast Radiation Therapy: Short-term Imaging Outcomes With Two Unique Treatment Regimens.” In International Journal of Radiation Oncology*Biology*Physics, 93:E46–E46. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.658.
    Full Text
  - Jagsi, R., K. A. Griffith, J. R. Bellon, W. A. Woodward, J. K. Horton, A. Y. Ho, A. Schott, and L. J. Pierce. “TBCRC 024 Initial Results: A Multicenter Phase 1 Study of Veliparib Administered Concurrently With Chest Wall and Nodal Radiation Therapy in Patients With Inflammatory or Locoregionally Recurrent Breast Cancer.” In International Journal of Radiation Oncology*Biology*Physics, 93:S137–S137. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.326.
    Full Text
  - Nichols, E., S. J. Feigenberg, M. Morgan, W. Citron, S. Kesmodel, E. Bellavance, C. Drogula, et al. “Preoperative External Beam APBI: Report of Acute Toxicities From 2 Prospective Clinical Trials Using Two Different Fractionation Schemes.” In International Journal of Radiation Oncology*Biology*Physics, 93:E49–E49. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.666.
    Full Text
  - Wang, C., J. K. Horton, F. F. Yin, and Z. Chang. “Treatment Assessment Using Dynamic Fractal Signature Dissimilarity as a Novel Biomarker for Early-Stage Breast Cancer Radiation Therapy: A Feasibility Study.” In International Journal of Radiation Oncology*Biology*Physics, 93:S5–S5. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.018.
    Full Text
  - Yoo, S., J. K. Horton, F. F. Yin, and R. Blitzblau. “Dosimetric Effect of the Prone Breast Board and the Couch Top for Whole-Breast Treatment in Prone Position.” In International Journal of Radiation Oncology*Biology*Physics, 93:E610–E610. Elsevier BV, 2015. https://doi.org/10.1016/j.ijrobp.2015.07.2105.
    Full Text
  - Lee, Chen-Ting, Yingchun Zhou, Sharareh Siamakpour-Reihani, Kingshuk R. Choudhury, Mark W. Dewhirst, and Janet K. Horton. “Abstract 3302: Subtype-specific radiation response in a mouse model of human breast cancer.” In Tumor Biology. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-3302.
    Full Text
  - Siamakpour-Reihani, Sharareh, Wei Chen, Chen-Ting Lee, Yingchun Zhou, Kouros Owzar, Jen-Tsan Chi, and Janet K. Horton. “Abstract 3331: Gene expression profiling after radiation in human breast cancer specimens and breast cancer cell lines.” In Tumor Biology. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-3331.
    Full Text
  - Arya, Ritu, Lee W. Jones, Rachel C. Blitzblau, Manisha Palta, Lisa Massa, Gloria Broadwater, and Janet K. Horton. “Abstract P2-12-07: The association between exercise behavior and patient-reported outcomes in women with early breast cancer receiving locoregional radiation therapy.” In Poster Session Abstracts. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.sabcs14-p2-12-07.
    Full Text
  - Mowery, Yvonne M., Rachel A. Greenup, Kevin Houck, Manisha Palta, Janet K. Horton, Eun-Sil S. Hwang, Julie A. Sosa, and Rachel C. Blitzblau. “Abstract P1-15-10: Low utilization of hypofractionated radiotherapy for the treatment of early-stage breast cancer in the US.” In Poster Session Abstracts. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.sabcs14-p1-15-10.
    Full Text
  - Palta, Manisha, Priya Palta, Nrupen A. Bhavsar, Janet K. Horton, and Rachel C. Blitzblau. “The use of adjuvant radiotherapy in elderly patients with early-stage breast cancer: changes in practice patterns after publication of Cancer and Leukemia Group B 9343.” In Cancer, 121:188–93, 2015. https://doi.org/10.1002/cncr.28937.
    Full Text Link to Item
  - Horton, J. K., R. Blitzblau, S. Yoo, G. Georgiade, J. Geradts, J. Baker, J. A. Chi, et al. “Preoperative Partial Breast Radiation Therapy: One Year Outcomes and Radiation-Induced Changes in Gene Expression.” In International Journal of Radiation Oncology*Biology*Physics, 90:S135–S135. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2014.05.588.
    Full Text
  - Wang, C., J. K. Horton, F. Yin, and Z. Chang. “Early Stage Breast Cancer Radiation Treatment Assessment Using Diffusion Weighted MRI and Dynamic Contrast Enhanced MRI.” In International Journal of Radiation Oncology*Biology*Physics, 90:S43–S43. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2014.05.166.
    Full Text
  - Yoo, S., R. Blitzblau, F. Yin, and J. K. Horton. “Delivered Dose for Preoperative Single Fraction Partial Breast Radiation Therapy.” In International Journal of Radiation Oncology*Biology*Physics, 90:S239–S239. Elsevier BV, 2014. https://doi.org/10.1016/j.ijrobp.2014.05.850.
    Full Text
  - Horton, J. K., R. C. Blitzblau, S. Yoo, G. S. Georgiade, J. Geradts, J. A. Baker, Z. Chang, et al. “Abstract P5-14-04: Preoperative single-fraction partial breast radiotherapy – Initial results from a novel phase I dose-escalation protocol with exploration of radiation response biomarkers.” In Poster Session Abstracts. American Association for Cancer Research, 2013. https://doi.org/10.1158/0008-5472.sabcs13-p5-14-04.
    Full Text
  - Horton, J. K., R. C. Blitzblau, S. Yoo, G. S. Georgiade, J. Geradts, J. A. Baker, Z. Chang, E. Duffy, and E. S. Hwang. “Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1 Dose-Escalation Protocol and Exploration of Breast Cancer Radiation Response.” In International Journal of Radiation Oncology*Biology*Physics, 87:S229–S229. Elsevier BV, 2013. https://doi.org/10.1016/j.ijrobp.2013.06.594.
    Full Text
  - Yoo, S., R. Blitzblau, F. Yin, and J. K. Horton. “Comparison of Preoperative Partial Breast Radiosurgery Treatment Techniques: 3D-CRT, Non-Coplanar IMRT, Coplanar IMRT, and VMAT.” In International Journal of Radiation Oncology*Biology*Physics, 87:S215–S215. Elsevier BV, 2013. https://doi.org/10.1016/j.ijrobp.2013.06.557.
    Full Text
  - Chang, Z., F. Yin, S. Yoo, and J. Horton. “SU‐E‐CAMPUS‐J‐04: Evaluating Radiation‐Induced Changes with Diffusion Weighted MRI and Dynamic Contrast Enhanced MRI in Patients with Early Stage Breast Cancer Treated with Stereotactic Body Radiotherapy: Initial Results.” In Medical Physics, 40:378–79, 2013. https://doi.org/10.1118/1.4815176.
    Full Text
  - Horton, J. K., D. R. Fels, H. Kung, K. Ashcraft, M. W. Dewhirst, and J. A. Chi. “Gene Expression Response to Ionizing Radiation in Luminal and Basal Breast Cancer Cell Lines.” In International Journal of Radiation Oncology*Biology*Physics, 84:S710–S710. Elsevier BV, 2012. https://doi.org/10.1016/j.ijrobp.2012.07.1900.
    Full Text
  - Shah, M. M., J. Peppercorn, C. N. Lee, G. Broadwater, and J. K. Horton. “Impact of a Photograph-based Educational Tool on Patient Knowledge and Satisfaction Regarding Cosmetic Outcomes after Breast Conservation Therapy: A Pilot Study.” In International Journal of Radiation Oncology*Biology*Physics, 78:S232–33. Elsevier BV, 2010. https://doi.org/10.1016/j.ijrobp.2010.07.557.
    Full Text
  - Yoo, S., J. O’daniel, J. Horton, Q. wu, and F. Yin. “SU‐GG‐T‐583: Dosimetric Comparison of Anisotropic Analytical and Pencil Beam Convolution Algorithms in Breast Cancer Radiation Treatment Planning.” In Medical Physics, 37:3321, 2010. https://doi.org/10.1118/1.3468984.
    Full Text
  - Palta, M., S. Yoo, and J. K. Horton. “Feasibility of Preoperative Single Fraction Partial Breast Radiotherapy for Early Stage Breast Cancer.” In Cancer Research, 69:741S-741S. AMER ASSOC CANCER RESEARCH, 2009.
    Link to Item
  - Horton, J. K., M. M. Shaw, J. Hubbs, S. Demirci, M. Patrone, K. L. Light, K. Temple, and L. B. Marks. “Treatment Volume and Toxicity Outcomes: The Duke Partial Breast Experience.” In International Journal of Radiation Oncology*Biology*Physics, 75:S207–8. Elsevier BV, 2009. https://doi.org/10.1016/j.ijrobp.2009.07.481.
    Full Text

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers