Overview
My research is focused on mathematical modeling of the dynamics of biological systems using systems of ordinary differential equations, and calibrating those equations to data. Specifically, I am interested in two distinct areas of application: within host viral/immune system modeling and models of complex antibody-antigen binding kinetics.
I believe strongly that the future direction of biomedical research is in team science. My inter-disciplinary training has provided me with the skills to communicate effectively with both biologists and mathematicians, creating a bridge that helps to unite the team and move projects forward.
I believe strongly that the future direction of biomedical research is in team science. My inter-disciplinary training has provided me with the skills to communicate effectively with both biologists and mathematicians, creating a bridge that helps to unite the team and move projects forward.
Current Appointments & Affiliations
Medical Instructor in Biostatistics & Bioinformatics
·
2019 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Recent Publications
Modeling BK Virus Infection in Renal Transplant Recipients.
Journal Article Viruses · December 31, 2024 Kidney transplant recipients require a lifelong protocol of immunosuppressive therapy to prevent graft rejection. However, these same medications leave them susceptible to opportunistic infections. One pathogen of particular concern is human polyomavirus 1 ... Full text Open Access Link to item CiteAssessing the impact of autologous virus neutralizing antibodies on viral rebound time in postnatally SHIV-infected ART-treated infant rhesus macaques.
Journal Article Epidemics · September 2024 While the benefits of early antiretroviral therapy (ART) initiation in perinatally infected infants are well documented, early initiation is not always possible in postnatal pediatric HIV infections. The timing of ART initiation is likely to affect the siz ... Full text Link to item CiteVariants in ZFX are associated with an X-linked neurodevelopmental disorder with recurrent facial gestalt.
Journal Article Am J Hum Genet · March 7, 2024 Pathogenic variants in multiple genes on the X chromosome have been implicated in syndromic and non-syndromic intellectual disability disorders. ZFX on Xp22.11 encodes a transcription factor that has been linked to diverse processes including oncogenesis a ... Full text Link to item CiteRecent Grants
Multiscale Modeling of Influenza Neutralizing Antibody and Fc Effector Biology
ResearchClinical Instructor · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029Quantitative Methods for HIV/AIDS Research
Inst. Training Prgm or CMETraining Faculty · Awarded by National Institute of Allergy and Infectious Diseases · 2018 - 2028Training Program in Bioinformatics at the Intersection of Cancer Immunology and Microbiome
ResearchTraining Faculty · Awarded by National Cancer Institute · 2020 - 2026View All Grants
Education, Training & Certifications
Duke University ·
2009
Ph.D.