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Jared Dean Christensen

Professor of Radiology
Radiology, Cardiothoracic Imaging
Department of Radiology, Box 3808 Med Ctr, Durham, NC 27710

Selected Publications


ACR Appropriateness Criteria® Sepsis

Journal Article Journal of the American College of Radiology · June 1, 2024 Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. A search for the underlying cause of infection typically includes radiological imaging as part of this investigation. This document focuses on th ... Full text Cite

Radiographic Imaging of Community-Acquired Pneumonia: A Case-Based Review.

Journal Article Infect Dis Clin North Am · March 2024 The chest radiograph is the most common imaging examination performed in most radiology departments, and one of the more common indications for these studies is suspected infection. Radiologists must therefore be aware of less common radiographic patterns ... Full text Link to item Cite

ACR Lung-RADS v2022: Assessment Categories and Management Recommendations.

Journal Article Chest · March 2024 The American College of Radiology created the Lung CT Screening Reporting and Data System (Lung-RADS) in 2014 to standardize the reporting and management of screen-detected pulmonary nodules. Lung-RADS was updated to version 1.1 in 2019 and revised size th ... Full text Link to item Cite

ACR Lung-RADS v2022: Assessment Categories and Management Recommendations.

Journal Article J Am Coll Radiol · March 2024 The ACR created the Lung CT Screening Reporting and Data System (Lung-RADS) in 2014 to standardize the reporting and management of screen-detected pulmonary nodules. Lung-RADS was updated to version 1.1 in 2019 and revised size thresholds for nonsolid nodu ... Full text Link to item Cite

Characterizing Lung-RADS category 4 lesions in a university lung cancer screening program.

Journal Article Lung Cancer · December 2023 OBJECTIVES: To assess the prevalence of lung cancer in Lung-RADS category 4 patients, and to elucidate if clinical or imaging features help differentiate benign lesions from lung cancer. MATERIALS/METHODS: A retrospective review of lung cancer screening (L ... Full text Link to item Cite

ACR Appropriateness Criteria® Routine Chest Imaging.

Journal Article J Am Coll Radiol · May 2023 Routine chest imaging has been used to identify unknown or subclinical cardiothoracic abnormalities in the absence of symptoms. Various imaging modalities have been suggested for routine chest imaging. We review the evidence for or against the use of routi ... Full text Link to item Cite

Divergent Interpretations of Imaging After Stereotactic Body Radiation Therapy for Lung Cancer.

Journal Article Pract Radiat Oncol · 2023 PURPOSE: Conflicting information from health care providers contributes to anxiety among cancer patients. The purpose of this study was to investigate discordant interpretations of follow-up imaging studies after lung stereotactic body radiation therapy (S ... Full text Link to item Cite

Radiographic Imaging of Community-Acquired Pneumonia: A Case-Based Review.

Journal Article Radiol Clin North Am · May 2022 The chest radiograph is the most common imaging examination performed in most radiology departments, and one of the more common indications for these studies is suspected infection. Radiologists must therefore be aware of less common radiographic patterns ... Full text Link to item Cite

ACR Appropriateness Criteria® Diffuse Lung Disease.

Journal Article J Am Coll Radiol · November 2021 Diffuse lung disease, frequently referred to as interstitial lung disease, encompasses numerous disorders affecting the lung parenchyma. The potential etiologies of diffuse lung disease are broad with several hundred established clinical syndromes and path ... Full text Link to item Cite

ACR Appropriateness Criteria® Nontraumatic Chest Wall Pain.

Journal Article J Am Coll Radiol · November 2021 Chest pain is a common reason that patients may present for evaluation in both ambulatory and emergency department settings, and is often of musculoskeletal origin in the former. Chest wall syndrome collectively describes the various entities that can cont ... Full text Link to item Cite

Interpreting Post-SBRT Lung Imaging: A Comparison of Radiology and Radiation Oncology Impressions.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Stereotactic body radiation therapy (SBRT) is an established treatment option for stage I non-small cell lung cancer. SBRT often causes acute inflammatory changes in the lung as well as chronic fibrosis. These radiologic findin ... Full text Cite

Lung-RADS Version 1.1: Challenges and a Look Ahead, From the AJR Special Series on Radiology Reporting and Data Systems.

Journal Article AJR Am J Roentgenol · June 2021 In 2014, the American College of Radiology (ACR) created Lung-RADS 1.0. The system was updated to Lung-RADS 1.1 in 2019, and further updates are anticipated as additional data become available. Lung-RADS provides a common lexicon and standardized nodule fo ... Full text Link to item Cite

Cardiac computed tomography improves the identification of cardiomechanical complications among patients with suspected left ventricular assist device malfunction.

Journal Article Journal of cardiovascular computed tomography · May 2021 BackgroundLeft ventricular assist devices (LVAD) are increasingly used for durable mechanical circulatory support in advanced heart failure. While LVAD therapy provides substantial improvement in mortality and quality of life, long-term therapy co ... Full text Cite

Validation of lesion simulations in clinical CT data for anonymized chest and abdominal CT databases.

Journal Article Med Phys · April 2019 PURPOSE: To make available to the medical imaging community a computed tomography (CT) image database composed of hybrid datasets (patient CT images with digitally inserted anthropomorphic lesions) where lesion ground truth is known a priori. It is envisio ... Full text Link to item Cite

Geographic Access to CT for Lung Cancer Screening: A Census Tract-Level Analysis of Cigarette Smoking in the United States and Driving Distance to a CT Facility.

Journal Article J Am Coll Radiol · January 2019 PURPOSE: Spatial access to health care resources is a requisite for utilization. Our purpose was to determine, at a census tract level, the geographic distribution of US smokers and their driving distance to an ACR-accredited CT facility. METHODS: The numb ... Full text Link to item Cite

Multidisciplinary Management of Oligometastatic Soft Tissue Sarcoma.

Journal Article Am Soc Clin Oncol Educ Book · May 23, 2018 Soft tissue sarcomas (STS) encompass a group of rare but heterogeneous diseases. Nevertheless, many patients, particularly those with oligometastatic disease can benefit from thoughtful multimodality evaluation and treatment regardless of the STS subtype. ... Full text Link to item Cite

Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · March 2018 BACKGROUND: The objective of this study was to evaluate the safety and feasibility of using neoadjuvant chemotherapy plus ipilimumab followed by surgery as a treatment strategy for stage II-IIIA non-small cell lung cancer. METHODS: From 2013 to 2017, posto ... Full text Link to item Cite

Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab.

Journal Article Clin Cancer Res · December 15, 2017 Purpose: To determine the immunologic effects of neoadjuvant chemotherapy plus ipilimumab in early-stage non-small cell lung cancer (NSCLC) patients.Experimental Design: This is a single-arm chemotherapy plus phased ipilimumab phase II study of 24 treatmen ... Full text Link to item Cite

Altered Nulling of Myocardium and Blood Pool.

Journal Article J Thorac Imaging · January 2017 Full text Link to item Cite

Maximum-Intensity-Projection and Computer-Aided-Detection Algorithms as Stand-Alone Reader Devices in Lung Cancer Screening Using Different Dose Levels and Reconstruction Kernels.

Journal Article AJR Am J Roentgenol · August 2016 OBJECTIVE: The objective of our study was to evaluate lung nodule detection rates on standard and microdose chest CT with two different computer-aided detection systems (SyngoCT-CAD, VA 20, Siemens Healthcare [CAD1]; Lung CAD, IntelliSpace Portal DX Server ... Full text Link to item Cite

ACR Appropriateness Criteria® Sepsis

Journal Article Journal of the American College of Radiology · June 1, 2024 Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. A search for the underlying cause of infection typically includes radiological imaging as part of this investigation. This document focuses on th ... Full text Cite

Radiographic Imaging of Community-Acquired Pneumonia: A Case-Based Review.

Journal Article Infect Dis Clin North Am · March 2024 The chest radiograph is the most common imaging examination performed in most radiology departments, and one of the more common indications for these studies is suspected infection. Radiologists must therefore be aware of less common radiographic patterns ... Full text Link to item Cite

ACR Lung-RADS v2022: Assessment Categories and Management Recommendations.

Journal Article Chest · March 2024 The American College of Radiology created the Lung CT Screening Reporting and Data System (Lung-RADS) in 2014 to standardize the reporting and management of screen-detected pulmonary nodules. Lung-RADS was updated to version 1.1 in 2019 and revised size th ... Full text Link to item Cite

ACR Lung-RADS v2022: Assessment Categories and Management Recommendations.

Journal Article J Am Coll Radiol · March 2024 The ACR created the Lung CT Screening Reporting and Data System (Lung-RADS) in 2014 to standardize the reporting and management of screen-detected pulmonary nodules. Lung-RADS was updated to version 1.1 in 2019 and revised size thresholds for nonsolid nodu ... Full text Link to item Cite

Characterizing Lung-RADS category 4 lesions in a university lung cancer screening program.

Journal Article Lung Cancer · December 2023 OBJECTIVES: To assess the prevalence of lung cancer in Lung-RADS category 4 patients, and to elucidate if clinical or imaging features help differentiate benign lesions from lung cancer. MATERIALS/METHODS: A retrospective review of lung cancer screening (L ... Full text Link to item Cite

ACR Appropriateness Criteria® Routine Chest Imaging.

Journal Article J Am Coll Radiol · May 2023 Routine chest imaging has been used to identify unknown or subclinical cardiothoracic abnormalities in the absence of symptoms. Various imaging modalities have been suggested for routine chest imaging. We review the evidence for or against the use of routi ... Full text Link to item Cite

Divergent Interpretations of Imaging After Stereotactic Body Radiation Therapy for Lung Cancer.

Journal Article Pract Radiat Oncol · 2023 PURPOSE: Conflicting information from health care providers contributes to anxiety among cancer patients. The purpose of this study was to investigate discordant interpretations of follow-up imaging studies after lung stereotactic body radiation therapy (S ... Full text Link to item Cite

Radiographic Imaging of Community-Acquired Pneumonia: A Case-Based Review.

Journal Article Radiol Clin North Am · May 2022 The chest radiograph is the most common imaging examination performed in most radiology departments, and one of the more common indications for these studies is suspected infection. Radiologists must therefore be aware of less common radiographic patterns ... Full text Link to item Cite

ACR Appropriateness Criteria® Diffuse Lung Disease.

Journal Article J Am Coll Radiol · November 2021 Diffuse lung disease, frequently referred to as interstitial lung disease, encompasses numerous disorders affecting the lung parenchyma. The potential etiologies of diffuse lung disease are broad with several hundred established clinical syndromes and path ... Full text Link to item Cite

ACR Appropriateness Criteria® Nontraumatic Chest Wall Pain.

Journal Article J Am Coll Radiol · November 2021 Chest pain is a common reason that patients may present for evaluation in both ambulatory and emergency department settings, and is often of musculoskeletal origin in the former. Chest wall syndrome collectively describes the various entities that can cont ... Full text Link to item Cite

Interpreting Post-SBRT Lung Imaging: A Comparison of Radiology and Radiation Oncology Impressions.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Stereotactic body radiation therapy (SBRT) is an established treatment option for stage I non-small cell lung cancer. SBRT often causes acute inflammatory changes in the lung as well as chronic fibrosis. These radiologic findin ... Full text Cite

Lung-RADS Version 1.1: Challenges and a Look Ahead, From the AJR Special Series on Radiology Reporting and Data Systems.

Journal Article AJR Am J Roentgenol · June 2021 In 2014, the American College of Radiology (ACR) created Lung-RADS 1.0. The system was updated to Lung-RADS 1.1 in 2019, and further updates are anticipated as additional data become available. Lung-RADS provides a common lexicon and standardized nodule fo ... Full text Link to item Cite

Cardiac computed tomography improves the identification of cardiomechanical complications among patients with suspected left ventricular assist device malfunction.

Journal Article Journal of cardiovascular computed tomography · May 2021 BackgroundLeft ventricular assist devices (LVAD) are increasingly used for durable mechanical circulatory support in advanced heart failure. While LVAD therapy provides substantial improvement in mortality and quality of life, long-term therapy co ... Full text Cite

Validation of lesion simulations in clinical CT data for anonymized chest and abdominal CT databases.

Journal Article Med Phys · April 2019 PURPOSE: To make available to the medical imaging community a computed tomography (CT) image database composed of hybrid datasets (patient CT images with digitally inserted anthropomorphic lesions) where lesion ground truth is known a priori. It is envisio ... Full text Link to item Cite

Geographic Access to CT for Lung Cancer Screening: A Census Tract-Level Analysis of Cigarette Smoking in the United States and Driving Distance to a CT Facility.

Journal Article J Am Coll Radiol · January 2019 PURPOSE: Spatial access to health care resources is a requisite for utilization. Our purpose was to determine, at a census tract level, the geographic distribution of US smokers and their driving distance to an ACR-accredited CT facility. METHODS: The numb ... Full text Link to item Cite

Multidisciplinary Management of Oligometastatic Soft Tissue Sarcoma.

Journal Article Am Soc Clin Oncol Educ Book · May 23, 2018 Soft tissue sarcomas (STS) encompass a group of rare but heterogeneous diseases. Nevertheless, many patients, particularly those with oligometastatic disease can benefit from thoughtful multimodality evaluation and treatment regardless of the STS subtype. ... Full text Link to item Cite

Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · March 2018 BACKGROUND: The objective of this study was to evaluate the safety and feasibility of using neoadjuvant chemotherapy plus ipilimumab followed by surgery as a treatment strategy for stage II-IIIA non-small cell lung cancer. METHODS: From 2013 to 2017, posto ... Full text Link to item Cite

Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab.

Journal Article Clin Cancer Res · December 15, 2017 Purpose: To determine the immunologic effects of neoadjuvant chemotherapy plus ipilimumab in early-stage non-small cell lung cancer (NSCLC) patients.Experimental Design: This is a single-arm chemotherapy plus phased ipilimumab phase II study of 24 treatmen ... Full text Link to item Cite

Altered Nulling of Myocardium and Blood Pool.

Journal Article J Thorac Imaging · January 2017 Full text Link to item Cite

Maximum-Intensity-Projection and Computer-Aided-Detection Algorithms as Stand-Alone Reader Devices in Lung Cancer Screening Using Different Dose Levels and Reconstruction Kernels.

Journal Article AJR Am J Roentgenol · August 2016 OBJECTIVE: The objective of our study was to evaluate lung nodule detection rates on standard and microdose chest CT with two different computer-aided detection systems (SyngoCT-CAD, VA 20, Siemens Healthcare [CAD1]; Lung CAD, IntelliSpace Portal DX Server ... Full text Link to item Cite

What's New in 10 Years? A Revised Cardiothoracic Curriculum for Diagnostic Radiology Residency with Goals and Objectives Related to General Competencies.

Journal Article Acad Radiol · July 2016 This is a cardiothoracic curriculum document for radiology residents meant to serve not only as a study guide for radiology residents but also as a teaching and curriculum reference for radiology educators and radiology residency program directors. This do ... Full text Link to item Cite

Catheter Drainage of Intrathoracic Collections

Chapter · April 22, 2016 Packed with useful information on common procedures in interventional radiology, this popular handbook has been thoroughly updated to keep you up to speed with rapid changes in the field. ... Cite

Adaptive planning using positron emission tomography for locally advanced lung cancer: A feasibility study.

Journal Article Pract Radiat Oncol · 2016 PURPOSE: To evaluate the feasibility of adaptive planning using positron emission tomography-computed tomography (PET-CT) in locally advanced non-small cell lung cancer. METHODS AND MATERIALS: Patients with locally advanced non-small cell lung cancer recei ... Full text Link to item Cite

Low-dose computed tomographic screening for lung cancer.

Journal Article Clin Chest Med · June 2015 Low-dose computed tomographic (LDCT) screening is now moving from clinical trials to clinical practice, following the report from the National Lung Screening Trial that LDCT screening for lung cancer can reduce the number of deaths from lung cancer by 20% ... Full text Link to item Cite

TH-AB-201-12: A Consumer Report for Mobile Digital Radiography: A Holistic Comparative Evaluation Across Four Systems.

Journal Article Med Phys · June 2015 PURPOSE: To provide a template for the comprehensive clinical evaluation of new imaging technologies with initial application to mobile digital radiography (DR). METHODS: Four mobile DR devices (GE Optima XR220amx+Flashpad; Carestream DRX Revolution+DRX-1C ... Full text Link to item Cite

In Reply to Giron et al.

Journal Article Pract Radiat Oncol · 2015 Full text Link to item Cite

Imaging of complications of thoracic and cardiovascular surgery.

Journal Article Radiol Clin North Am · September 2014 Iatrogenic complications of thoracic and cardiovascular surgery are relatively uncommon, but contribute to potentially significant patient morbidity and mortality. The incidence of iatrogenic disease reflects the complexity of surgical procedures, includin ... Full text Link to item Cite

Tumor acquisition for biomarker research in lung cancer.

Journal Article Cancer Invest · July 2014 The biopsy collection data from two lung cancer trials that required fresh tumor samples be obtained for microarray analysis were reviewed. In the trial for advanced disease, microarray data were obtained on 50 patient samples, giving an overall success ra ... Full text Link to item Cite

Assessment of vascular contrast and wall motion of the aortic root and ascending aorta on MDCT angiography: dual-source high-pitch vs non-gated single-source acquisition schemes.

Journal Article Eur Radiol · May 2014 OBJECTIVES: This retrospective study assessed whether dual-source high-pitch computed tomographic angiography (CTA) offered advantages over single-source standard-pitch techniques in the evaluation of the ascending aorta. METHODS: Twenty patients who recei ... Full text Link to item Cite

Computed tomography screening for lung cancer: where are we now?

Journal Article North Carolina medical journal · September 2013 Low-dose computed tomography (LDCT) screening has been shown to result in detection of earlier-stage lung cancers, with a 20% reduction in cancer-related deaths. LDCT screening offers significant potential benefits to selected patients; however, many quest ... Cite

Oncologic Imaging/Oncologic Anatomy

Chapter · June 5, 2013 Inside the Sixth Edition of this now-classic reference, you will discover encyclopedic coverage of topics ranging from basic science to sophisticated computer-based radiation therapy treatment planning and supportive care. ... Cite

Ascending thoracic aorta: postoperative imaging evaluation.

Journal Article Radiographics · 2013 Advances in computed tomography (CT) scanners and electrocardiographic gating techniques have resulted in superior image quality of the ascending aorta and increased the use of CT angiography for evaluating the postoperative ascending aorta. Several abnorm ... Full text Link to item Cite

Future trends in lung cancer diagnosis.

Journal Article Radiol Clin North Am · September 2012 Imaging continues to play an essential role in evaluating patients with lung cancer. Improvement in radiologic techniques will produce more accurate diagnostic information, but complementing conventional studies with molecular diagnostics will likely have ... Full text Link to item Cite

Chest radiology

Chapter · January 19, 2012 Cite

Chest radiology: Case 24

Chapter · January 19, 2012 Cite

Gray-scale inversion radiographic display for the detection of pulmonary nodules on chest radiographs.

Journal Article Clin Imaging · 2012 The purpose of this study was to investigate gray-scale inversion in nodule detection on chest radiography. Simulated nodules were superimposed randomly onto normal chest radiographs. Six radiologists interpreted 144 chest radiographs during three reading ... Full text Link to item Cite

Effects of iopamidol-370 versus iodixanol-320 on coronary contrast, branch depiction, and heart rate variability in dual-source coronary MDCT angiography.

Journal Article AJR Am J Roentgenol · September 2011 OBJECTIVE: The purpose of this article is to assess whether iopamidol-370 provides superior vascular contrast of the coronaries and depiction of anatomic detail without affecting heart rate and beat-to-beat variability during coronary dual-source MDCT comp ... Full text Link to item Cite

Utility of FDG PET/CT in inflammatory cardiovascular disease.

Journal Article Radiographics · 2011 Inflammatory disorders of the cardiovascular system can affect the myocardium, pericardium, or vessel walls. Patients with myocardial and pericardial disease may present with chest pain, palpitations, and shortness of breath, symptoms resembling myocardial ... Full text Link to item Cite

Correlation of [18F]-2-fluoro-deoxy-D-glucose positron emission tomography standard uptake values with the cellular composition of stage I nonsmall cell lung cancer.

Journal Article Cancer · September 1, 2010 BACKGROUND: The aim of the current study was to determine whether the [18F]-2-fluoro-deoxy-D-glucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) in patients with a new diagnosis of stage I lung cancer correlates with a specific ... Full text Link to item Cite

Real-time sonoelastography of hepatic thermal lesions in a swine model.

Journal Article Med Phys · September 2008 Sonoelastography has been developed as an ultrasound-based elasticity imaging technique. In this technique, external vibration is induced into the target tissue. In general, tissue stiffness is inversely proportional to the amplitude of tissue vibration. I ... Full text Link to item Cite

Multimodality imaging in the diagnosis of deep vein thrombosis and popliteal pseudoaneurysm complicating a sessile osteochondroma.

Journal Article Pediatr Radiol · August 2008 Synergistic use of ultrasonography, radiography, multidetector CT (MDCT) and MRI enabled a prompt and accurate diagnosis of a nonocclusive popliteal vein thrombus (deep venous thrombosis, DVT) and a pseudoaneurysm complicating a sessile osteochondroma in a ... Full text Link to item Cite

Measurement of thermally ablated lesions in sonoelastographic images using level set methods

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · May 7, 2008 The capability of sonoelastography to detect lesions based on elasticity contrast can be applied to monitor the creation of thermally ablated lesion. Currently, segmentation of lesions depicted in sonoelastographic images is performed manually which can be ... Full text Cite

Real-time semi-automatic segmentation of hepatic radiofrequency ablated lesions in an in vivo porcine model using sonoelastography

Journal Article Proceedings - IEEE Ultrasonics Symposium · December 1, 2007 Radiofrequency ablation (RFA) is a minimally invasive thermal therapy that is under investigation as an alternative to surgery for treating liver tumors. Currently, there is a need to monitor the process of lesion creation to guarantee complete treatment o ... Full text Cite

The undescended testis.

Journal Article Semin Ultrasound CT MR · August 2007 Cryptorchidism represents a common condition affecting male infants that has significant clinical implications, including infertility and testicular malignancy. The precise developmental mechanisms leading to cryptorchidism are poorly understood; however, ... Full text Link to item Cite

New Advances in Genitourinary Ultrasound

Journal Article Ultrasound Clinics · January 1, 2007 Since its clinical introduction in the 1940s, ultrasound has become one of the most widely used imaging modalities in medicine and has emerged as a key diagnostic tool for the evaluation of patients who have genitourinary disease. This is largely attributa ... Full text Cite

Isoflurane, but not halothane, induces protection of human myocardium via adenosine A1 receptors and adenosine triphosphate-sensitive potassium channels.

Journal Article Anesthesiology · June 2000 BACKGROUND: Volatile anesthetics produce differing degrees of myocardial protection in animal models of ischemia. The purpose of the current investigation was to determine the influence of isoflurane and halothane on myocardial protection in a human model ... Full text Link to item Cite

Interactions between propofol and lipid mediator receptors: inhibition of lysophosphatidate signaling.

Journal Article Anesth Analg · November 1996 As a highly lipophilic drug, propofol may interact with lipophilic domains in addition to its likely primary site of action on the gamma-aminobutyrateA) (GABA(A)) receptor. Likely candidates for such interaction are the G protein-coupled membrane receptors ... Full text Link to item Cite