Scholars@Duke
Jeffrey W Cooney

Jeffrey W Cooney

Assistant Professor of Neurology
Neurology, Movement Disorders

Selected Publications

Initial Clinical Outcome With Bilateral, Dual-Target Deep Brain Stimulation Trial in Parkinson Disease Using Summit RC + S.

Journal Article Neurosurgery · July 1, 2022 BACKGROUND: Deep brain stimulation (DBS) is an effective therapy in advanced Parkinson disease (PD). Although both subthalamic nucleus (STN) and globus pallidus (GP) DBS show equivalent efficacy in PD, combined stimulation may demonstrate synergism. OBJECT ... Full text Open Access Link to item Cite

Telemedicine and Deep brain stimulation - Current practices and recommendations.

Journal Article Parkinsonism Relat Disord · August 2021 The use of telemedicine in the management of chronic neurological conditions including movement disorders has expanded over time. In addition to enabling remote access to specialized care, telemedicine has also been shown to reduce caregiver burden and to ... Full text Link to item Cite

Mindfulness based stress reduction in people with Parkinson's disease and their care partners.

Journal Article Complement Ther Clin Pract · May 2021 BACKGROUND: Parkinson's Disease (PD) leads to poor quality of life and caregiver burden. Mindfulness-based stress reduction (MBSR) may improve these symptoms. We assessed the impact of a 9-week MBSR course on people with PD (PwP) and their care partners (C ... Full text Open Access Link to item Cite

Corticobasal syndrome in a man with Gaucher disease type 1: Expansion of the understanding of the neurological spectrum.

Journal Article Mol Genet Metab Rep · December 2018 Gaucher disease (GD) is an autosomal recessive condition that results from a deficiency of the enzyme β-glucocerebrosidase. The increased risk of primary parkinsonism symptoms among individuals affected with GD and carriers for the disorder is well-documen ... Full text Open Access Link to item Cite

Guidance for switching from off-label antipsychotics to pimavanserin for Parkinson's disease psychosis: an expert consensus.

Journal Article CNS Spectr · December 2018 Patients with Parkinson's disease psychosis (PDP) are often treated with an atypical antipsychotic, especially quetiapine or clozapine, but side effects, lack of sufficient efficacy, or both may motivate a switch to pimavanserin, the first medication appro ... Full text Open Access Link to item Cite

Neuropsychiatric Issues in Parkinson's Disease.

Journal Article Curr Neurol Neurosci Rep · May 2016 Cognitive and neuropsychiatric symptoms are common in Parkinson's Disease and may surpass motor symptoms as the major factors impacting patient quality of life. The symptoms may be broadly separated into those associated with the disease process and those ... Full text Open Access Link to item Cite

Hierarchical cognitive control deficits following damage to the human frontal lobe.

Journal Article Nat Neurosci · April 2009 Cognitive control permits us to make decisions about abstract actions, such as whether to e-mail versus call a friend, and to select the concrete motor programs required to produce those actions, based on our goals and knowledge. The frontal lobes are nece ... Full text Link to item Cite

Age-related deficits in component processes of working memory.

Journal Article Neuropsychology · September 2007 Working memory deficits in normal aging have been well documented, and studies suggest that high memory load plus the presence of distraction negatively impacts successful memory performance to a greater degree in older individuals. However, characterizati ... Full text Link to item Cite

Functional interactions between prefrontal and visual association cortex contribute to top-down modulation of visual processing.

Journal Article Cereb Cortex · September 2007 Attention-dependent modulation of neural activity in visual association cortex (VAC) is thought to depend on top-down modulatory control signals emanating from the prefrontal cortex (PFC). In a previous functional magnetic resonance imaging study utilizing ... Full text Link to item Cite

Is the prefrontal cortex necessary for delay task performance? Evidence from lesion and FMRI data.

Journal Article J Int Neuropsychol Soc · March 2006 Although the prefrontal cortex (PFC) is consistently found to be associated with various working memory processes, the necessity of the PFC for such processes remains unclear. To elucidate PFC contributions to storage and rehearsal/maintenance processes en ... Full text Link to item Cite

Top-down suppression deficit underlies working memory impairment in normal aging.

Journal Article Nat Neurosci · October 2005 In this study, we assess the impact of normal aging on top-down modulation, a cognitive control mechanism that supports both attention and memory by the suppression and enhancement of sensory processing in accordance with task goals. Using fMRI (functional ... Full text Link to item Cite

Top-down enhancement and suppression of the magnitude and speed of neural activity.

Journal Article J Cogn Neurosci · March 2005 Top-down modulation underlies our ability to selectively attend to relevant stimuli and to ignore irrelevant stimuli. Theories addressing neural mechanisms of top-down modulation are driven by studies that reveal increased magnitude of neural activity in r ... Full text Link to item Cite

Neurological disorders and the structure of human consciousness.

Journal Article Trends Cogn Sci · April 2003 Recent studies that identify distinct neural correlates of perceptual awareness offer a promising step towards improved understanding of the neurological underpinnings of conscious experience. Such studies indicate that perceptual awareness is modular in n ... Full text Link to item Cite