Overview
Current Appointments & Affiliations
Associate Professor of Pediatrics
·
2021 - Present
Pediatrics, Rheumatology,
Pediatrics
Recent Publications
Genetic changes from type I interferons and JAK inhibitors: clues to drivers of juvenile dermatomyositis.
Journal Article Rheumatology (Oxford) · September 1, 2024 OBJECTIVE: To better understand the pathogenesis of juvenile dermatomyositis (JDM), we examined the effect of the cytokines type I interferons (IFN I) and JAK inhibitor drugs (JAKi) on gene expression in bioengineered pediatric skeletal muscle. METHODS: My ... Full text Link to item CiteEffect of type I interferon on engineered pediatric skeletal muscle: a promising model for juvenile dermatomyositis.
Journal Article Rheumatology (Oxford) · January 4, 2024 OBJECTIVE: To investigate pathogenic mechanisms underlying JDM, we defined the effect of type I IFN, IFN-α and IFN-β, on pediatric skeletal muscle function and expression of myositis-related proteins using an in vitro engineered human skeletal muscle model ... Full text Link to item CiteTreatment of Rheumatic Diseases
Chapter · January 1, 2024 Full text CiteRecent Grants
Toward precision medicine for Juvenile Dermatomyositis: Development of a cross-tissue single-cell atlas
ResearchPrincipal Investigator · Awarded by University of Michigan · 2022 - 2026Pediatrics Juvenile Myositis program support
ResearchPrincipal Investigator · Awarded by Cure JM Foundation · 2019 - 2025Cell-free mitochondrial DNA induces type I interferon production in an experimental myobundle model of juvenile dermatomyositis (JDM).
ResearchPrincipal Investigator · Awarded by Cure JM Foundation · 2022 - 2023View All Grants
Education, Training & Certifications
University of Minnesota, Twin Cities ·
1993
M.D.