Jeffrey Arthur Dvergsten

Jeffrey Arthur Dvergsten
Associate Professor of Pediatrics

Disease pathogenesis particularly in JIA, JDM and systemic-onset JIA.

Current Research Interests

Juvenile idiopathic inflammatory myopathies. Chronic non-bacterial osteomyelitis. Auto-inflammatory conditions.

Current Appointments & Affiliations

Associate Professor of Pediatrics, Pediatrics, Rheumatology, Pediatrics 2021

Contact Information

jeffrey.dvergsten@duke.edu

Background
Education, Training, & Certifications
- Pediatric Rheumatology Fellowship, Pediatrics, University of Pittsburgh 2007 - 2010
- Pediatric Critical Care Medicine Fellowship, Pediatrics, University of Minnesota, Twin Cities 2002
- Pediatric Residency, Pediatrics, University of Minnesota, Twin Cities 1999 - 2002
- Medicine/Pediatrics Internship, Pediatrics/Medicine, University of Minnesota, Twin Cities 1993
- M.D., University of Minnesota, Twin Cities 1993
Previous Appointments & Affiliations
- Associate Professor of Pediatrics, Pediatrics, Rheumatology, Pediatrics 2020
- Assistant Professor of Pediatrics, Pediatrics, Rheumatology, Pediatrics 2010 - 2020
Expertise
Subject Headings
- Myositis
Research
Selected Grants
- Vamorolone in Juvenile Autoimmune Myositis awarded by Cure JM Foundation 2020 - 2022
- Pediatrics Juvenile Myositis program support awarded by Cure JM Foundation 2019 - 2022
- Metabolomic Analysis of Paired Serum and Skeletal Muscle in Juvenile Inflammatory Myositis Compared to Controls awarded by Cure JM Foundation 2017 - 2019
Fellowships, Supported Research, & Other Grants
- Metabolomiocs if Juvenile dermatomyositis awarded by Cure JM Foundation 2017
External Relationships
- Pfizer Inc.
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Dvergsten, Jeffrey A., Ann M. Reed, Lawrence Landerman, David S. Pisetsky, Olga Ilkayeva, and Kim M. Huffman. “Metabolomics analysis identifies a lipidomic profile in treatment-naïve juvenile dermatomyositis patients vs healthy control subjects.” Rheumatology (Oxford) 61, no. 4 (April 11, 2022): 1699–1708. https://doi.org/10.1093/rheumatology/keab520.
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  - Liu, Kuan, George Tomlinson, Ann M. Reed, Adam M. Huber, Olli Saarela, Sharon M. Bout-Tabaku, Megan Curran, et al. “Pilot Study of the Juvenile Dermatomyositis Consensus Treatment Plans: A CARRA Registry Study.” J Rheumatol 48, no. 1 (January 1, 2021): 114–22. https://doi.org/10.3899/jrheum.190494.
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  - Cannon, Laura, Jeffrey Dvergsten, and Cory Stingl. “Juvenile Dermatomyositis and Development of Malignancy: 2 Case Reports and a Literature Review.” J Rheumatol 47, no. 3 (March 2020): 479. https://doi.org/10.3899/jrheum.190929.
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  - Reed, Ann Marie, Cynthia S. Crowson, and Jeffrey Arthur Dvergsten. “A Path to Prediction of Outcomes in Juvenile Idiopathic Inflammatory Myopathy.” Front Immunol 10 (2019): 638. https://doi.org/10.3389/fimmu.2019.00638.
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  - Zhao, Yongdong, Eveline Y. Wu, Melissa S. Oliver, Ashley M. Cooper, Matthew L. Basiaga, Sheetal S. Vora, Tzielan C. Lee, et al. “Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and/or With Active Spinal Lesions.” Arthritis Care Res (Hoboken) 70, no. 8 (August 2018): 1228–37. https://doi.org/10.1002/acr.23462.
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  - Ferguson, Ian D., Patricia Griffin, Joshua J. Michel, Hiroshi Yano, Sarah L. Gaffen, Robert G. Mueller, Jeffrey A. Dvergsten, et al. “T Cell Receptor-Independent, CD31/IL-17A-Driven Inflammatory Axis Shapes Synovitis in Juvenile Idiopathic Arthritis.” Front Immunol 9 (2018): 1802. https://doi.org/10.3389/fimmu.2018.01802.
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  - Rider, Lisa G., Nicolino Ruperto, Angela Pistorio, Brian Erman, Nastaran Bayat, Peter A. Lachenbruch, Howard Rockette, et al. “2016 ACR-EULAR adult dermatomyositis and polymyositis and juvenile dermatomyositis response criteria-methodological aspects.” Rheumatology (Oxford) 56, no. 11 (November 1, 2017): 1884–93. https://doi.org/10.1093/rheumatology/kex226.
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  - Rider, Lisa G., Rohit Aggarwal, Angela Pistorio, Nastaran Bayat, Brian Erman, Brian M. Feldman, Adam M. Huber, et al. “2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.” Arthritis Rheumatol 69, no. 5 (May 2017): 911–23. https://doi.org/10.1002/art.40060.
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  - Kalampokis, Ioannis, Guglielmo M. Venturi, Jonathan C. Poe, Jeffrey A. Dvergsten, John W. Sleasman, and Thomas F. Tedder. “The Regulatory B Cell Compartment Expands Transiently During Childhood and Is Contracted in Children With Autoimmunity.” Arthritis Rheumatol 69, no. 1 (January 2017): 225–38. https://doi.org/10.1002/art.39820.
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  - Cabral, David A., Debra L. Canter, Eyal Muscal, Kabita Nanda, Dawn M. Wahezi, Steven J. Spalding, Marinka Twilt, et al. “Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener's): An ARChiVe Cohort Study.” Arthritis Rheumatol 68, no. 10 (October 2016): 2514–26. https://doi.org/10.1002/art.39729.
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  - Dvergsten, J. A., and A. M. Reed. “Progress and prognosis in juvenile dermatomyositis.” International Journal of Clinical Rheumatology 9, no. 6 (January 1, 2014): 567–84. https://doi.org/10.2217/ijr.14.46.
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  - Dvergsten, Jeffrey A., Robert G. Mueller, Patricia Griffin, Sameem Abedin, Allyson Pishko, Joshua J. Michel, Margalit E. Rosenkranz, Ann M. Reed, Daniel A. Kietz, and Abbe N. Vallejo. “Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis.” Arthritis Rheum 65, no. 8 (August 2013): 2201–10. https://doi.org/10.1002/art.38015.
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  - Vallejo, Abbe N., Robert G. Mueller, David L. Hamel, Amanda Way, Jeffrey A. Dvergsten, Patricia Griffin, and Anne B. Newman. “Expansions of NK-like αβT cells with chronologic aging: novel lymphocyte effectors that compensate for functional deficits of conventional NK cells and T cells.” Ageing Res Rev 10, no. 3 (July 2011): 354–61. https://doi.org/10.1016/j.arr.2010.09.006.
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  - Silkensen, J. R., K. M. Skubitz, A. P. Skubitz, D. H. Chmielewski, J. C. Manivel, J. A. Dvergsten, and M. E. Rosenberg. “Clusterin promotes the aggregation and adhesion of renal porcine epithelial cells.” J Clin Invest 96, no. 6 (December 1995): 2646–53. https://doi.org/10.1172/JCI118330.
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  - Nath, K. A., J. Dvergsten, R. Correa-Rotter, T. H. Hostetter, J. C. Manivel, and M. E. Rosenberg. “Induction of clusterin in acute and chronic oxidative renal disease in the rat and its dissociation from cell injury.” Lab Invest 71, no. 2 (August 1994): 209–18.
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  - Dvergsten, J., J. C. Manivel, R. Correa-Rotter, and M. E. Rosenberg. “Expression of clusterin in human renal diseases.” Kidney Int 45, no. 3 (March 1994): 828–35. https://doi.org/10.1038/ki.1994.109.
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  - Rosenberg, M. E., J. Dvergsten, and R. Correa-Rotter. “Clusterin: an enigmatic protein recruited by diverse stimuli.” J Lab Clin Med 121, no. 2 (February 1993): 205–14.
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- Book Sections
  - Dvergsten, Jeffrey, and Ann Reed. “Management Considerations: Juvenile Dermatomyositis.” In Managing Myositis A Practical Guide, edited by Rohit Aggarwal and Chester Oddis. Springer, 2019.
- Conference Papers
  - Ferguson, Ian D., Patricia Griffin, Hiroshi Yano, Joshua J. Michel, Jeffrey A. Dvergsten, Sarah L. Gaffen, Margalit E. Rosenkranz, Daniel A. Kietz, and Abbe N. Vallejo. “Interaction Between Senescent T Cells and Fibrocyte-like Cells through CD31, TNF alpha, and IL-17 Create a Tissue Destructive Environment in the Synovium in Juvenile Idiopathic Arthritis.” In Arthritis & Rheumatology, Vol. 67. WILEY-BLACKWELL, 2015.
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  - Kalampokis, Ioannis, Jeffrey A. Dvergsten, and Thomas Tedder. “The Interleukin-10 (IL-10) Producing Regulatory B Cell ("B10 cell") Compartment Expands with Disease Activity in Juvenile Dermatomyositis (JDM) and Pediatric-Onset Systemic Lupus Erythematosus (pSLE).” In Arthritis and Rheumatism, 64:S138–S138. WILEY-BLACKWELL, 2012.
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  - DVERGSTEN, J. A., and M. E. ROSENBERG. “RELATIONSHIP BETWEEN APOPTOSIS, CLUSTERIN AND THE CYTOSKELETON.” In Clinical Research, 40:A723–A723. SLACK INC, 1992.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Previous Appointments & Affiliations

Subject Headings

Selected Grants

Fellowships, Supported Research, & Other Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses