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Jeffrey Brian Russ

George W. Brumley, Jr. M.D Assistant Professor of Pediatrics
Pediatrics, Neurology
311 Research Drive, Box 2900, Durham, NC 27710
311 Research Drive, Box 2900, Durham, NC 27710

Overview


I divide my time between clinic and the laboratory. In clinic I focus primarily on fetal and neonatal patients with genetic disorders, brain malformations, prematurity, perinatal brain injury, and seizures. In the lab, I use a toolbox of mouse genetics, single-cell transcriptomics, and cell culture to study how cortical neurons change in response to perinatal brain injury and genetic neurodevelopmental disorders.

Current Appointments & Affiliations


George W. Brumley, Jr. M.D Assistant Professor of Pediatrics · 2023 - Present Pediatrics, Neurology, Pediatrics
Assistant Professor of Pediatrics · 2023 - Present Pediatrics, Neurology, Pediatrics
Assistant Professor in Neurology · 2025 - Present Neurology, Translational Brain Sciences, Neurology
Assistant Research Professor in Neurobiology · 2025 - Present Neurobiology, Basic Science Departments
Member of the Duke Cancer Institute · 2024 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published June 24, 2024
Neurological conditions claim the lives of thousands of children every year. New treatments in the womb may save them
Published November 2, 2023
Placental pathology and neurodevelopmental outcomes in patients with neonatal encephalopathy
Published April 7, 2023
Prepare for the Worst, Hope for the Best — Pediatric neurologist braces himself for worst case scenario

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Recent Publications


RNA-programmable cell-type monitoring and manipulation in the human cortex with CellREADR.

Journal Article Cell Rep · August 26, 2025 Reliable and systematic access to diverse cell types is necessary for understanding the organization, function, and pathophysiology of human neural circuits. Methods for targeting human neural populations are scarce and currently center on identifying tran ... Full text Link to item Cite
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Recent Grants


Discovering the cell type basis of the IT projection system and its dysregulation after perinatal HIE

ResearchPrincipal Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2024 - 2029

Optimizing Gene Therapy for Respiratory Insufficiency in Duchenne Muscular Dystrophy

ResearchCo Investigator · Awarded by National Heart, Lung, and Blood Institute · 2024 - 2028

A programmable, cell type-specific, RNA-based tool to treat diffuse intrinsic pontine glioma (DIPG)

ResearchPrincipal Investigator · Awarded by B*Cured · 2023 - 2024

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Education, Training & Certifications


Cornell University, Weill Medical College · 2016 MD./PhD.