Skip to main content

Jeffrey Brian Russ

George W. Brumley, Jr. M.D Assistant Professor of Pediatrics
Pediatrics, Neurology
311 Research Drive, Box 2900, Durham, NC 27710
311 Research Drive, Box 2900, Durham, NC 27710

Overview


I divide my time between clinic and the laboratory. In clinic I focus primarily on fetal and neonatal patients with genetic disorders, brain malformations, prematurity, perinatal brain injury, and seizures. In the lab, I use a toolbox of mouse genetics, single-cell transcriptomics, and cell culture to study how cortical neurons change in response to perinatal brain injury and genetic neurodevelopmental disorders.

Current Appointments & Affiliations


George W. Brumley, Jr. M.D Assistant Professor of Pediatrics · 2023 - Present Pediatrics, Neurology, Pediatrics
Assistant Professor of Pediatrics · 2023 - Present Pediatrics, Neurology, Pediatrics
Assistant Professor in Neurology · 2025 - Present Neurology, Translational Brain Sciences, Neurology
Assistant Research Professor in Neurobiology · 2025 - Present Neurobiology, Basic Science Departments
Member of the Duke Cancer Institute · 2024 - Present Duke Cancer Institute, Institutes and Centers
Faculty Network Member of the Duke Institute for Brain Sciences · 2025 - Present Duke Institute for Brain Sciences, University Institutes and Centers

In the News


Published June 24, 2024
Neurological conditions claim the lives of thousands of children every year. New treatments in the womb may save them
Published November 2, 2023
Placental pathology and neurodevelopmental outcomes in patients with neonatal encephalopathy
Published April 7, 2023
Prepare for the Worst, Hope for the Best — Pediatric neurologist braces himself for worst case scenario

View All News

Recent Publications


Two Novel Pediatric Cases of EIF4A2 -Related Disorder With Refractory Infantile Spasms.

Journal Article Am J Med Genet A · March 2026 With the rapid adoption and increasing use of genetic testing in pediatric neurology, the discovery and characterization of novel pathogenic variants resulting in neurodevelopmental and seizure disorders are becoming more common. One such disorder is EIF4A ... Full text Link to item Cite

Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes.

Journal Article Children (Basel) · December 30, 2025 In this narrative review, we examine current neurological and neurodevelopmental outcomes associated with extreme prematurity, specifically in infants born between 22 and 24 weeks of gestational age. In addition, we explore the scientific and clinical rati ... Full text Link to item Cite

Communicating neurological prognosis in the prenatal period: a narrative review and practice guidelines.

Journal Article Pediatr Res · November 2025 Clinicians may face an array of challenges in conducting fetal neurological consultations including prognostic uncertainty, a lack of training in fetal counseling, and limited opportunity to build rapport with families. In this setting, it is critical to e ... Full text Link to item Cite
View All Publications

Recent Grants


Discovering the cell type basis of the IT projection system and its dysregulation after perinatal HIE

ResearchPrincipal Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2024 - 2029

Optimizing Gene Therapy for Respiratory Insufficiency in Duchenne Muscular Dystrophy

ResearchCo Investigator · Awarded by National Heart, Lung, and Blood Institute · 2024 - 2028

A programmable, cell type-specific, RNA-based tool to treat diffuse intrinsic pontine glioma (DIPG)

ResearchPrincipal Investigator · Awarded by B*Cured · 2023 - 2024

View All Grants

Education


Cornell University, Weill Medical College · 2016 MD./PhD.