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Jeffrey J. Sapyta

Associate Professor in Psychiatry and Behavioral Sciences
Psychiatry, Child & Family Mental Health & Community Psychiatry
Duke Child and Family Study Center, 2608 Erwin Road- Suite 300, Durham, NC 27705
2608 Erwin Road Suite 300, Durham, NC 27705-4597

Selected Publications


The relationship between homework adherence and outcome in family-based cognitive-behavioral therapy for early-onset obsessive compulsive disorder

Journal Article Journal of Obsessive-Compulsive and Related Disorders · July 1, 2022 Family-based cognitive behavioral therapy (CBT) is an effective treatment for obsessive compulsive disorder (OCD), but not all children respond. Children with early-onset OCD may exhibit poorer outcomes, possibly due to developmental factors that affect tr ... Full text Cite

Systematic Review and Meta-analysis: An Empirical Approach to Defining Treatment Response and Remission in Pediatric Obsessive-Compulsive Disorder.

Journal Article J Am Acad Child Adolesc Psychiatry · April 2022 OBJECTIVE: A lack of universal definitions for response and remission in pediatric obsessive-compulsive disorder (OCD) has hampered the comparability of results across trials. To address this problem, we conducted an individual participant data diagnostic ... Full text Link to item Cite

Perceived changes in social interactions following military psychiatric hospitalization for a suicidal crisis.

Journal Article Mil Psychol · 2022 UNLABELLED: Introduction Changes in social interactions following psychiatric hospitalization, a period characterized by heightened suicide risk, are important to understand. OBJECTIVE: We qualitatively explored perceived changes in social interactions one ... Full text Link to item Cite

Attention-deficit/hyperactivity disorder and the explore/exploit trade-off.

Journal Article Neuropsychopharmacology · February 2021 The ability to maximize rewards and minimize the costs of obtaining them is vital to making advantageous explore/exploit decisions. Exploratory decisions are theorized to be greater among individuals with attention-deficit/hyperactivity disorder (ADHD), po ... Full text Link to item Cite

Feasibility of an Integrated Treatment Approach for Youth with Depression, Suicide Attempts, and Substance Use Problems.

Journal Article Evid Based Pract Child Adolesc Ment Health · 2021 Depression, suicidal behaviors and substance use problems frequently co-occur, and treatment for youth with these co-occurring problems is often fragmented and challenging. An integrated cognitive-behavioral treatment approach that builds upon a relapse pr ... Full text Link to item Cite

Methylphenidate increases willingness to perform effort in adults with ADHD.

Journal Article Pharmacol Biochem Behav · August 2019 BACKGROUND: A reduced willingness to perform effort based on the magnitude and probability of potential rewards has been associated with diminished dopamine function and may be relevant to attention-deficit/hyperactivity disorder (ADHD). Here, we investiga ... Full text Link to item Cite

Assessing Acute Secondary Treatment Outcomes in Early-Onset Obsessive-Compulsive Disorder.

Journal Article Child Psychiatry Hum Dev · October 2018 Obsessive-compulsive disorder (OCD) in children under 8 years of age, referred to as early-onset OCD, has similar features to OCD in older children, including moderate to severe symptoms, impairment, and significant comorbidity. Family-based cognitive beha ... Full text Link to item Cite

Children's and Parents' Ability to Tolerate Child Distress: Impact on Cognitive Behavioral Therapy for Pediatric Obsessive Compulsive Disorder.

Journal Article Child Psychiatry Hum Dev · April 2018 The present study explored the concept of tolerance for child distress in 46 children (ages 5-8), along with their mothers and fathers, who received family-based CBT for OCD. The study sought to describe baseline tolerance, changes in tolerance with treatm ... Full text Link to item Cite

Secondary outcomes from the pediatric obsessive compulsive disorder treatment study II.

Journal Article J Psychiatr Res · September 2017 UNLABELLED: The Pediatric Obsessive-Compulsive Disorder Treatment Study II (POTS II) investigated the benefit of serotonin reuptake inhibitor (SRI) augmentation with cognitive behavioral therapy (CBT). Primary outcomes focused on OCD symptom change and ind ... Full text Link to item Cite

Elevated Autism Spectrum Disorder Traits in Young Children with OCD.

Journal Article Child Psychiatry Hum Dev · December 2016 Studies have shown a high prevalence of autistic spectrum traits in both children and adults with psychiatric disorders; however the prevalence rate has not yet been investigated in young children with OCD. The aim of the current study was to (1) determine ... Full text Link to item Cite

Brief Report: Cognitive Control of Social and Nonsocial Visual Attention in Autism.

Journal Article J Autism Dev Disord · August 2016 Prosaccade and antisaccade errors in the context of social and nonsocial stimuli were investigated in youth with autism spectrum disorder (ASD; n = 19) a matched control sample (n = 19), and a small sample of youth with obsessive compulsive disorder (n = 9 ... Full text Link to item Cite

Assessment of Obsessive Compulsive Disorder in Young Children: Psychometric Properties of the Children’s Yale-Brown Obsessive Compulsive Scale

Journal Article Journal of Psychopathology and Behavioral Assessment · September 11, 2015 The Children’s Yale-Brown Obsessive Compulsive Scale (CY-BOCS) is the most commonly used instrument to assess the symptoms and severity of pediatric obsessive compulsive disorder (OCD). However, only one prior study has evaluated the psychometric propertie ... Full text Cite

Family-Based Treatment of Pediatric Obsessive-Compulsive Disorder: Clinical Considerations and Application.

Journal Article Child Adolesc Psychiatr Clin N Am · July 2015 Pediatric obsessive-compulsive disorder (OCD) can be effectively treated with family-based intervention by expanding and enhancing family members' behavioral repertoire to more effectively manage OCD symptoms and affected family interactions. This article ... Full text Link to item Cite

Suicide attempts in a longitudinal sample of adolescents followed through adulthood: Evidence of escalation.

Journal Article J Consult Clin Psychol · April 2015 OBJECTIVES: This study was designed to examine escalation in repeat suicide attempts from adolescence through adulthood, as predicted by sensitization models (and reflected in increasing intent and lethality with repeat attempts, decreasing amount of time ... Full text Link to item Cite

Tic-related obsessive-compulsive disorder (OCD): phenomenology and treatment outcome in the Pediatric OCD Treatment Study II.

Journal Article J Am Acad Child Adolesc Psychiatry · December 2014 OBJECTIVE: Prior research has shown that youth with co-occurring tic disorders and obsessive-compulsive disorder (OCD) may differ from those with non-tic-related OCD in terms of clinical characteristics and treatment responsiveness. A broad definition of " ... Full text Link to item Cite

Family-based treatment of early childhood obsessive-compulsive disorder: the Pediatric Obsessive-Compulsive Disorder Treatment Study for Young Children (POTS Jr)--a randomized clinical trial.

Journal Article JAMA Psychiatry · June 2014 IMPORTANCE: Cognitive behavior therapy (CBT) has been established as efficacious for obsessive-compulsive disorder (OCD) among older children and adolescents, yet its effect on young children has not been evaluated sufficiently. OBJECTIVE: To examine the r ... Full text Link to item Cite

Cognitive behavioral therapy for pediatric obsessive-compulsive disorder: development of expert-level competence and implications for dissemination.

Journal Article J Anxiety Disord · December 2013 Pediatric obsessive-compulsive disorder (OCD) is associated with substantial morbidity, comorbidity, family difficulties, and functional impairment. Fortunately, OCD in youth has also been found responsive to cognitive behavioral therapy (CBT) both alone a ... Full text Link to item Cite

The Pediatric Obsessive Compulsive Disorder Treatment Study for Young Children (POTS jr): Developmental Considerations in the Rationale, Design, and Methods.

Journal Article J Obsessive Compuls Relat Disord · October 2012 This paper presents the rationale, design, and methods of the Pediatric Obsessive Compulsive Disorder (OCD) Treatment Study for young children (POTS Jr). The study is a multi-site randomized controlled trial (RCT) of family-based Cognitive Behavioral Treat ... Full text Link to item Cite

Evaluating the predictive validity of suicidal intent and medical lethality in youth.

Journal Article J Consult Clin Psychol · April 2012 OBJECTIVES: To examine whether suicidal intent and medical lethality of past suicide attempts are predictive of future attempts, the association between intent and lethality, and the consistency of these characteristics across repeated attempts among youth ... Full text Link to item Cite

Cognitive behavior therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorder: the Pediatric OCD Treatment Study II (POTS II) randomized controlled trial.

Journal Article JAMA · September 21, 2011 CONTEXT: The extant literature on the treatment of pediatric obsessive-compulsive disorder (OCD) indicates that partial response to serotonin reuptake inhibitors (SRIs) is the norm and that augmentation with short-term OCD-specific cognitive behavior thera ... Full text Link to item Cite

Still Struggling: characteristics of youth with OCD who are partial responders to medication treatment.

Journal Article Child Psychiatry Hum Dev · August 2011 The primary aim of this paper is to examine the characteristics of a large sample of youth with OCD who are partial responders (i.e., still have clinically significant symptoms) to serotonin reuptake inhibitor (SRI) medication. The sample will be described ... Full text Link to item Cite

Predictors of parental accommodation in pediatric obsessive-compulsive disorder: findings from the Pediatric Obsessive-Compulsive Disorder Treatment Study (POTS) trial.

Journal Article J Am Acad Child Adolesc Psychiatry · July 2011 OBJECTIVE: Few studies have examined predictors of parental accommodation (assessed with the Family Accommodation Scale-Parent Report) among families of children with obsessive-compulsive disorder (OCD). No studies have examined this phenomenon using empir ... Full text Link to item Cite

Examining the psychometric properties of the family accommodation scale-parent-report (FAS-PR)

Journal Article Journal of Psychopathology and Behavioral Assessment · March 1, 2011 Growing research has examined parental accommodation among the families of children with obsessive-compulsive disorder (OCD). However, these studies have utilized a parent-report (PR) version of a measure, the Family Accommodation Scale (FAS) that has neve ... Full text Cite

Predictors and moderators of treatment outcome in the Pediatric Obsessive Compulsive Treatment Study (POTS I).

Journal Article J Am Acad Child Adolesc Psychiatry · October 2010 OBJECTIVE: To identify predictors and moderators of outcome in the first Pediatric OCD Treatment Study (POTS I) among youth (N = 112) randomly assigned to sertraline, cognitive behavioral therapy (CBT), both sertraline and CBT (COMB), or a pill placebo. ME ... Full text Link to item Cite

The impact of neuropsychological functioning on treatment outcome in pediatric obsessive-compulsive disorder.

Journal Article Depress Anxiety · April 2010 BACKGROUND: Scant research has examined the effect of neuropsychological (NP) functioning on treatment outcome in pediatric obsessive-compulsive disorder (OCD). This study sought to address this gap in existing research. METHODS: A total of 63 youths were ... Full text Link to item Cite

Hepatitis C and depressive symptoms: psychological and social factors matter more than liver injury.

Journal Article Int J Psychiatry Med · 2010 OBJECTIVE: Given that the hepatitis C virus (HCV) crosses the blood-brain barrier, biological factors are commonly blamed for the high rates of mood disturbance in HCV-infected patients. However, no study assessing the potential contribution of psychosocia ... Full text Link to item Cite

The Pediatric Obsessive-Compulsive Disorder Treatment Study II: rationale, design and methods.

Journal Article Child Adolesc Psychiatry Ment Health · January 30, 2009 UNLABELLED: This paper presents the rationale, design, and methods of the Pediatric Obsessive-Compulsive Disorder Treatment Study II (POTS II), which investigates two different cognitive-behavior therapy (CBT) augmentation approaches in children and adoles ... Full text Link to item Cite

Cognitive behavioral treatment for young children with obsessive-compulsive disorder.

Journal Article Biol Psychiatry · February 1, 2007 Obsessive-compulsive disorder (OCD) is a distressing and functionally impairing disorder that can emerge as early as age 4. Cognitive behavior therapy (CBT) for OCD in youth shows great promise for amelioration of symptoms and associated functional impairm ... Full text Link to item Cite

Feedback to clinicians: theory, research, and practice.

Journal Article J Clin Psychol · February 2005 Despite the dearth of consistent evidence for conventional feedback mechanisms in clinical practice, the primary methods of feedback for clinicians remain supervision and clinical experience. A new research approach, known as patient-focused research, prov ... Full text Link to item Cite

Youth therapeutic alliance in intensive treatment settings.

Journal Article J Behav Health Serv Res · 2004 Therapeutic alliance (TA), the helping relationship that develops between a client and clinician, has received little attention in child treatment studies until recently, though it is the factor found to be most predictive of clinical outcomes. Furthermore ... Full text Link to item Cite

The pediatric obsessive-compulsive disorder treatment study: rationale, design, and methods.

Journal Article J Child Adolesc Psychopharmacol · 2003 Obsessive-compulsive disorder (OCD), which has a prevalence of 1 in 200 in children and adolescents, carries with it significant functional morbidity. A growing empirical literature supports the efficacy of short-term treatment with OCD-specific cognitive- ... Full text Link to item Cite

Subjective Well-Being Is Essential to Well-Being

Journal Article Psychological Inquiry · January 1, 1998 Full text Cite