Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Emory University 2001
• 

  Previous Appointments & Affiliations

  • Assistant Professor in Medicine, Medicine, Medical Oncology, Medicine 2021
  • Assistant Professor in Medicine, Medicine, Medical Oncology, Medicine 2013 - 2020
• Research
• 

  Selected Grants

  • Race-related differential RNA splicing: novel targets for precision oncology in non-small cell lung cancer awarded by National Institutes of Health 2020 - 2025
  • Race-Related Alternative Splicing: Novel Targets in Prostate Cancer awarded by National Institutes of Health 2017 - 2023
  • Reducing prostate cancer aggressiveness via aptamer-mediated nuclear delivery of splice-switching oligonucleotides awarded by Department of Defense 2020 - 2023
  • Small Molecule Targeting Of RNAs Driving Tumor Aggressiveness awarded by United States Army Medical Research Acquisition Activity 2020 - 2023
  • Ancestry-related RNA splicing and immune expression in metastatic breast cancer awarded by Susan G. Komen Breast Cancer Foundation 2022
  • Race-related differential RNA splicing: novel targets for precision oncology in non-small cell lung cancer awarded by Department of Defense 2020 - 2022
  • Targeting RNA splicing in race-related aggressive and lethal prostate cancer awarded by Prostate Cancer Foundation 2018 - 2022
  • Race-related germline genetic variation and response to secondary hormonal therapy in metastatic castration-resistant prostate cancer awarded by Department of Defense 2019 - 2022
  • Interrogating Race-related Alternative Splicing Variation in Metastasis awarded by American Association for Cancer Research 2020 - 2022
  • PC150506: Small molecule targeting of RNA splice variants driving tumor aggressiveness awarded by United States Army Medical Research Acquisition Activity 2016 - 2020
  • Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate cancer awarded by Department of Defense 2014 - 2020
  • Race-related differential splicing of the insulin receptor and prostate tumor cell biology awarded by National Institutes of Health 2016 - 2020
  • Identification of Genetic Determinates for Disparities in African American Patients with Non-Small Cell Lung Cancer awarded by V Foundation for Cancer Research 2016 - 2018
  • Aptamer Targeted Drug and Toxin Delivery to Prostate Cancer awarded by Department of Defense 2014 - 2016
• 

  External Relationships

  • MPG-CAS Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences
  • TheraSplice
• Publications & Artistic Works
• 

  Selected Publications

  • Books

    • Freedman, Jennifer A., Muthana Al Abo, Tyler A. Allen, Sean A. Piwarski, Kara Wegermann, and Steven R. Patierno. Biological Aspects of Cancer Health Disparities. Vol. 72, 2021. https://doi.org/10.1146/annurev-med-070119-120305.
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  • Academic Articles

    • Zhang, Sirui, Miaowei Mao, Yuesheng Lv, Yingqun Yang, Weijing He, Yongmei Song, Yongbo Wang, et al. “A widespread length-dependent splicing dysregulation in cancer.” Sci Adv 8, no. 33 (August 19, 2022): eabn9232. https://doi.org/10.1126/sciadv.abn9232.
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    • Yang, Wenjun, Hongliang Liu, Ruoxin Zhang, Jennifer A. Freedman, Younghun Han, Rayjean J. Hung, Yonathan Brhane, et al. “Deciphering associations between three RNA splicing-related genetic variants and lung cancer risk.” Npj Precis Oncol 6, no. 1 (June 30, 2022): 48. https://doi.org/10.1038/s41698-022-00281-9.
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    • Al Abo, Muthana, Larisa Gearhart-Serna, Steven Van Laere, Jennifer A. Freedman, Steven R. Patierno, Eun-Sil Shelley Hwang, Savitri Krishnamurthy, Kevin P. Williams, and Gayathri R. Devi. “Adaptive stress response genes associated with breast cancer subtypes and survival outcomes reveal race-related differences.” Npj Breast Cancer 8, no. 1 (June 13, 2022): 73. https://doi.org/10.1038/s41523-022-00431-z.
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    • Hyun, Jeongeun, Muthana Al Abo, Rajesh Kumar Dutta, Seh Hoon Oh, Kun Xiang, Xiyou Zhou, Raquel Maeso-Díaz, et al. “Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease.” J Hepatol 75, no. 3 (September 2021): 623–33. https://doi.org/10.1016/j.jhep.2021.04.033.
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    • George, Daniel J., Susan Halabi, Elisabeth I. Heath, A Oliver Sartor, Guru P. Sonpavde, Devika Das, Rhonda L. Bitting, et al. “A prospective trial of abiraterone acetate plus prednisone in Black and White men with metastatic castrate-resistant prostate cancer.” Cancer 127, no. 16 (August 15, 2021): 2954–65. https://doi.org/10.1002/cncr.33589.
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    • Al Abo, Muthana, Terry Hyslop, Xiaodi Qin, Kouros Owzar, Daniel J. George, Steven R. Patierno, and Jennifer A. Freedman. “Differential alternative RNA splicing and transcription events between tumors from African American and White patients in The Cancer Genome Atlas.” Genomics 113, no. 3 (May 2021): 1234–46. https://doi.org/10.1016/j.ygeno.2021.02.020.
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    • Deveaux, April E., Tyler A. Allen, Muthana Al Abo, Xiaodi Qin, Dadong Zhang, Brendon M. Patierno, Lin Gu, et al. “RNA splicing and aggregate gene expression differences in lung squamous cell carcinoma between patients of West African and European ancestry.” Lung Cancer 153 (March 2021): 90–98. https://doi.org/10.1016/j.lungcan.2021.01.015.
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    • Allen, Tyler A., Mark M. Cullen, Nathan Hawkey, Hiroyuki Mochizuki, Lan Nguyen, Elyse Schechter, Luke Borst, et al. “A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation.” Front Oncol 11 (2021): 641187. https://doi.org/10.3389/fonc.2021.641187.
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    • Robinson, Timothy J., Jennifer A. Freedman, Muthana Al Abo, April E. Deveaux, Bonnie LaCroix, Brendon M. Patierno, Daniel J. George, and Steven R. Patierno. “Alternative RNA Splicing as a Potential Major Source of Untapped Molecular Targets in Precision Oncology and Cancer Disparities.” Clin Cancer Res 25, no. 10 (May 15, 2019): 2963–68. https://doi.org/10.1158/1078-0432.CCR-18-2445.
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    • Freedman, Jennifer A., Yanru Wang, Xuechan Li, Hongliang Liu, Patricia G. Moorman, Daniel J. George, Norman H. Lee, Terry Hyslop, Qingyi Wei, and Steven R. Patierno. “Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival.” Carcinogenesis 39, no. 7 (July 3, 2018): 879–88. https://doi.org/10.1093/carcin/bgy062.
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    • Wang, Bi-Dar, Kristin Ceniccola, SuJin Hwang, Ramez Andrawis, Anelia Horvath, Jennifer A. Freedman, Jacqueline Olender, et al. “Corrigendum: Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer.” Nat Commun 8 (September 27, 2017): 16161. https://doi.org/10.1038/ncomms16161.
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    • Wang, Yanru, Jennifer A. Freedman, Hongliang Liu, Patricia G. Moorman, Terry Hyslop, Daniel J. George, Norman H. Lee, Steven R. Patierno, and Qingyi Wei. “Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer.” Int J Cancer 141, no. 4 (August 15, 2017): 731–43. https://doi.org/10.1002/ijc.30787.
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    • Wang, Bi-Dar, Kristin Ceniccola, SuJin Hwang, Ramez Andrawis, Anelia Horvath, Jennifer A. Freedman, Jacqueline Olender, et al. “Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer.” Nat Commun 8 (June 30, 2017): 15921. https://doi.org/10.1038/ncomms15921.
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    • Ramalingam, Sundhar, Adva Eisenberg, Wen Chi Foo, Jennifer Freedman, Andrew J. Armstrong, Larry G. Moss, and Michael R. Harrison. “Treatment-related neuroendocrine prostate cancer resulting in Cushing's syndrome.” Int J Urol 23, no. 12 (December 2016): 1038–41. https://doi.org/10.1111/iju.13225.
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    • Longo, Thomas, Kathleen F. McGinley, Jennifer A. Freedman, Wiguins Etienne, Yuan Wu, Alexander Sibley, Kouros Owzar, et al. “Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer.” Eur Urol 70, no. 5 (November 2016): 714–17. https://doi.org/10.1016/j.eururo.2016.07.049.
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    • Ware, Kathryn E., Jason A. Somarelli, Daneen Schaeffer, Jing Li, Tian Zhang, Sally Park, Steven R. Patierno, et al. “Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer.” Oncotarget 7, no. 31 (August 2, 2016): 50507–21. https://doi.org/10.18632/oncotarget.10476.
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    • Augustine, C. K., J. A. Freedman, G. M. Beasley, and D. S. Tyler. “Melanoma” 2 (August 29, 2013): 765–75. https://doi.org/10.1016/B978-0-12-382227-7.00066-5.
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    • Kim, Mickey K., Takuya Osada, William T. Barry, Xiao Yi Yang, Jennifer A. Freedman, Katherine A. Tsamis, Michael Datto, et al. “Characterization of an oxaliplatin sensitivity predictor in a preclinical murine model of colorectal cancer.” Mol Cancer Ther 11, no. 7 (July 2012): 1500–1509. https://doi.org/10.1158/1535-7163.MCT-11-0937.
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    • Freedman, Jennifer A., Christina K. Augustine, Angelica M. Selim, Kirsten C. Holshausen, Zhengzheng Wei, Katherine A. Tsamis, David S. Hsu, et al. “A methodology for utilization of predictive genomic signatures in FFPE samples.” Bmc Med Genomics 4 (July 11, 2011): 58. https://doi.org/10.1186/1755-8794-4-58.
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    • Freedman, Jennifer A., Douglas S. Tyler, Joseph R. Nevins, and Christina K. Augustine. “Use of gene expression and pathway signatures to characterize the complexity of human melanoma.” Am J Pathol 178, no. 6 (June 2011): 2513–22. https://doi.org/10.1016/j.ajpath.2011.02.037.
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    • Freedman, J. A., J. T. Chang, L. Jakoi, and J. R. Nevins. “A combinatorial mechanism for determining the specificity of E2F activation and repression.” Oncogene 28, no. 32 (August 13, 2009): 2873–81. https://doi.org/10.1038/onc.2009.153.
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    • Freedman, Jennifer A., and Sue Jinks-Robertson. “Effects of mismatch repair and Hpr1 on transcription-stimulated mitotic recombination in the yeast Saccharomyces cerevisiae.” Dna Repair (Amst) 3, no. 11 (November 2, 2004): 1437–46. https://doi.org/10.1016/j.dnarep.2004.06.005.
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    • Lippert, Malcolm J., Jennifer A. Freedman, Melissa A. Barber, and Sue Jinks-Robertson. “Identification of a distinctive mutation spectrum associated with high levels of transcription in yeast.” Mol Cell Biol 24, no. 11 (June 2004): 4801–9. https://doi.org/10.1128/MCB.24.11.4801-4809.2004.
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    • Freedman, Jennifer A., and Sue Jinks-Robertson. “Genetic requirements for spontaneous and transcription-stimulated mitotic recombination in Saccharomyces cerevisiae.” Genetics 162, no. 1 (September 2002): 15–27. https://doi.org/10.1093/genetics/162.1.15.
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    • Chen, C. M., J. A. Freedman, D. R. Bettler, S. D. Manning, S. N. Giep, J. Steiner, and H. M. Ellis. “Polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in Drosophila.” Mech Dev 57, no. 2 (July 1996): 215–27. https://doi.org/10.1016/0925-4773(96)00548-5.
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  • Book Sections

    • Augustine, C. K., J. A. Freedman, G. M. Beasley, and D. S. Tyler. “Melanoma.” In Genomic and Personalized Medicine, 765–75, 2012. https://doi.org/10.1016/B978-0-12-382227-7.00066-5.
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  • Conference Papers

    • Patierno, Brendon M., Wen-Chi Foo, Tyler Allen, Jason A. Somarelli, Kathryn E. Ware, Santosh Gupta, Sandra Wise, et al. “Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry.” In Prostate Cancer Prostatic Dis, 25:513–23, 2022. https://doi.org/10.1038/s41391-021-00460-y.
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