Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Emory University 2001
• Research
• 

  Selected Grants

  • Race-related alternative splicing: novel targets in prostate cancer awarded by National Institutes of Health 2017 - 2022
  • PC150506: Small molecule targeting of RNA splice variants driving tumor aggressiveness awarded by United States Army Medical Research Acquisition Activity 2016 - 2019
  • Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate ca awarded by Department of Defense 2014 - 2019
  • Identification of Genetic Determinates for Disparities in African American Patients with Non-Small Cell Lung Cancer awarded by V Foundation for Cancer Research 2016 - 2018
  • Aptamer Targeted Drug and Toxin Delivery to Prostate Cancer awarded by Department of Defense 2014 - 2016
• Publications & Artistic Works
• 

  Selected Publications

  • Journal Articles

    • Freedman, JA, Wang, Y, Li, X, Liu, H, Moorman, PG, George, DJ, Lee, NH, Hyslop, T, Wei, Q, and Patierno, SR. "Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival." Carcinogenesis 39, no. 7 (July 2018): 879-888.  Full Text
    • Wang, Y, Freedman, JA, Liu, H, Moorman, PG, Hyslop, T, George, DJ, Lee, NH, Patierno, SR, and Wei, Q. "Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer." International Journal of Cancer 141, no. 4 (August 2017): 731-743.  Full Text
    • Wang, B-D, Ceniccola, K, Hwang, S, Andrawis, R, Horvath, A, Freedman, JA, Olender, J, Knapp, S, Ching, T, Garmire, L, Patel, V, Garcia-Blanco, MA, Patierno, SR, and Lee, NH. "Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer." Nature Communications 8 (June 30, 2017): 15921-null.  Full Text
    • Ramalingam, S, Eisenberg, A, Foo, WC, Freedman, J, Armstrong, AJ, Moss, LG, and Harrison, MR. "Treatment-related neuroendocrine prostate cancer resulting in Cushing's syndrome." Int J Urol 23, no. 12 (December 2016): 1038-1041.  Full Text  Link to Item
    • Longo, T, McGinley, KF, Freedman, JA, Etienne, W, Wu, Y, Sibley, A, Owzar, K, Gresham, J, Moy, C, Szabo, S, Greshock, J, Zhou, H, Bai, Y, and Inman, BA. "Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer." European Urology 70, no. 5 (November 2016): 714-717.  Full Text
    • Ware, KE, Somarelli, JA, Schaeffer, D, Li, J, Zhang, T, Park, S, Patierno, SR, Freedman, J, Foo, W-C, Garcia-Blanco, MA, and Armstrong, AJ. "Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer." Oncotarget 7, no. 31 (August 2016): 50507-50521.  Full Text  Open Access Copy
    • Augustine, CK, Freedman, JA, Beasley, GM, and Tyler, DS. "Melanoma." 2 (August 29, 2013): 765-775. (Chapter)  Full Text
    • Kim, MK, Osada, T, Barry, WT, Yang, XY, Freedman, JA, Tsamis, KA, Datto, M, Clary, BM, Clay, T, Morse, MA, Febbo, PG, Lyerly, HK, and Hsu, DS. "Characterization of an oxaliplatin sensitivity predictor in a preclinical murine model of colorectal cancer." Molecular Cancer Therapeutics 11, no. 7 (July 2012): 1500-1509.  Full Text
    • Freedman, JA, Augustine, CK, Selim, AM, Holshausen, KC, Wei, Z, Tsamis, KA, Hsu, DS, Dressman, HK, Barry, WT, Tyler, DS, and Nevins, JR. "A methodology for utilization of predictive genomic signatures in FFPE samples. (Published online)" BMC Med Genomics 4 (July 11, 2011): 58-.  Full Text  Link to Item
    • Freedman, JA, Tyler, DS, Nevins, JR, and Augustine, CK. "Use of gene expression and pathway signatures to characterize the complexity of human melanoma." Am J Pathol 178, no. 6 (June 2011): 2513-2522.  Full Text  Link to Item
    • Freedman, JA, Chang, JT, Jakoi, L, and Nevins, JR. "A combinatorial mechanism for determining the specificity of E2F activation and repression." Oncogene 28, no. 32 (August 13, 2009): 2873-2881.  Full Text  Link to Item
    • Lippert, MJ, Freedman, JA, Barber, MA, and Jinks-Robertson, S. "Identification of a distinctive mutation spectrum associated with high levels of transcription in yeast." Molecular and Cellular Biology 24, no. 11 (June 2004): 4801-4809.  Full Text
    • Freedman, JA, and Jinks-Robertson, S. "Effects of mismatch repair and Hpr1 on transcription-stimulated mitotic recombination in the yeast Saccharomyces cerevisiae." DNA Repair 3, no. 11 (2004): 1437-1446.  Full Text
    • Freedman, JA, and Jinks-Robertson, S. "Genetic requirements for spontaneous and transcription-stimulated mitotic recombination in Saccharomyces cerevisiae." Genetics 162, no. 1 (2002): 15-27.
    • Chen, C-M, Freedman, JA, Jr, DRB, Manning, SD, Giep, SN, Steiner, J, and Ellis, HM. "polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in Drosophila." Mechanisms of Development 57, no. 2 (1996): 215-227.  Full Text

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