Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Emory University 2001
• Research
• 

  Selected Grants

  • Race-related germline genetic variation and response to secondary hormonal therapy in metastatic castration-resistant prostate cancer awarded by Department of Defense 2019 - 2022
  • Race-Related Alternative Splicing: Novel Targets in Prostate Cancer awarded by National Institutes of Health 2017 - 2022
  • Targeting RNA splicing in race-related aggressive and lethal prostate cancer 2018 - 2020
  • PC150506: Small molecule targeting of RNA splice variants driving tumor aggressiveness 2016 - 2019
  • Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate ca awarded by Department of Defense 2014 - 2019
  • Identification of Genetic Determinates for Disparities in African American Patients with Non-Small Cell Lung Cancer awarded by V Foundation for Cancer Research 2016 - 2018
  • Aptamer Targeted Drug and Toxin Delivery to Prostate Cancer awarded by Department of Defense 2014 - 2016
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Robinson, Timothy J., Jennifer A. Freedman, Muthana Al Abo, April E. Deveaux, Bonnie LaCroix, Brendon M. Patierno, Daniel J. George, and Steven R. Patierno. “Alternative RNA Splicing as a Potential Major Source of Untapped Molecular Targets in Precision Oncology and Cancer Disparities..” Clin Cancer Res 25, no. 10 (May 15, 2019): 2963–68. https://doi.org/10.1158/1078-0432.CCR-18-2445.
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    • Freedman, Jennifer A., Yanru Wang, Xuechan Li, Hongliang Liu, Patricia G. Moorman, Daniel J. George, Norman H. Lee, Terry Hyslop, Qingyi Wei, and Steven R. Patierno. “Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival..” Carcinogenesis 39, no. 7 (July 3, 2018): 879–88. https://doi.org/10.1093/carcin/bgy062.
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    • Wang, Bi-Dar, Kristin Ceniccola, SuJin Hwang, Ramez Andrawis, Anelia Horvath, Jennifer A. Freedman, Jacqueline Olender, et al. “Corrigendum: Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer..” Nat Commun 8 (September 27, 2017). https://doi.org/10.1038/ncomms16161.
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    • Wang, Yanru, Jennifer A. Freedman, Hongliang Liu, Patricia G. Moorman, Terry Hyslop, Daniel J. George, Norman H. Lee, Steven R. Patierno, and Qingyi Wei. “Associations between RNA splicing regulatory variants of stemness-related genes and racial disparities in susceptibility to prostate cancer..” Int J Cancer 141, no. 4 (August 15, 2017): 731–43. https://doi.org/10.1002/ijc.30787.
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    • Wang, Bi-Dar, Kristin Ceniccola, SuJin Hwang, Ramez Andrawis, Anelia Horvath, Jennifer A. Freedman, Jacqueline Olender, et al. “Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer..” Nat Commun 8 (June 30, 2017). https://doi.org/10.1038/ncomms15921.
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    • Ramalingam, Sundhar, Adva Eisenberg, Wen Chi Foo, Jennifer Freedman, Andrew J. Armstrong, Larry G. Moss, and Michael R. Harrison. “Treatment-related neuroendocrine prostate cancer resulting in Cushing's syndrome..” Int J Urol 23, no. 12 (December 2016): 1038–41. https://doi.org/10.1111/iju.13225.
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    • Longo, Thomas, Kathleen F. McGinley, Jennifer A. Freedman, Wiguins Etienne, Yuan Wu, Alexander Sibley, Kouros Owzar, et al. “Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer..” Eur Urol 70, no. 5 (November 2016): 714–17. https://doi.org/10.1016/j.eururo.2016.07.049.
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    • Ware, Kathryn E., Jason A. Somarelli, Daneen Schaeffer, Jing Li, Tian Zhang, Sally Park, Steven R. Patierno, et al. “Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer..” Oncotarget 7, no. 31 (August 2, 2016): 50507–21. https://doi.org/10.18632/oncotarget.10476.
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    • Augustine, C. K., J. A. Freedman, G. M. Beasley, and D. S. Tyler. “Melanoma” 2 (August 29, 2013): 765–75. https://doi.org/10.1016/B978-0-12-382227-7.00066-5.
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    • Kim, Mickey K., Takuya Osada, William T. Barry, Xiao Yi Yang, Jennifer A. Freedman, Katherine A. Tsamis, Michael Datto, et al. “Characterization of an oxaliplatin sensitivity predictor in a preclinical murine model of colorectal cancer..” Mol Cancer Ther 11, no. 7 (July 2012): 1500–1509. https://doi.org/10.1158/1535-7163.MCT-11-0937.
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    • Freedman, Jennifer A., Christina K. Augustine, Angelica M. Selim, Kirsten C. Holshausen, Zhengzheng Wei, Katherine A. Tsamis, David S. Hsu, et al. “A methodology for utilization of predictive genomic signatures in FFPE samples..” Bmc Med Genomics 4 (July 11, 2011). https://doi.org/10.1186/1755-8794-4-58.
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    • Freedman, Jennifer A., Douglas S. Tyler, Joseph R. Nevins, and Christina K. Augustine. “Use of gene expression and pathway signatures to characterize the complexity of human melanoma..” Am J Pathol 178, no. 6 (June 2011): 2513–22. https://doi.org/10.1016/j.ajpath.2011.02.037.
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    • Freedman, J. A., J. T. Chang, L. Jakoi, and J. R. Nevins. “A combinatorial mechanism for determining the specificity of E2F activation and repression..” Oncogene 28, no. 32 (August 13, 2009): 2873–81. https://doi.org/10.1038/onc.2009.153.
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    • Freedman, Jennifer A., and Sue Jinks-Robertson. “Effects of mismatch repair and Hpr1 on transcription-stimulated mitotic recombination in the yeast Saccharomyces cerevisiae..” Dna Repair (Amst) 3, no. 11 (November 2, 2004): 1437–46. https://doi.org/10.1016/j.dnarep.2004.06.005.
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    • Lippert, Malcolm J., Jennifer A. Freedman, Melissa A. Barber, and Sue Jinks-Robertson. “Identification of a distinctive mutation spectrum associated with high levels of transcription in yeast..” Mol Cell Biol 24, no. 11 (June 2004): 4801–9. https://doi.org/10.1128/MCB.24.11.4801-4809.2004.
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    • Freedman, Jennifer A., and Sue Jinks-Robertson. “Genetic requirements for spontaneous and transcription-stimulated mitotic recombination in Saccharomyces cerevisiae..” Genetics 162, no. 1 (September 2002): 15–27.
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    • Chen, C. M., J. A. Freedman, D. R. Bettler, S. D. Manning, S. N. Giep, J. Steiner, and H. M. Ellis. “Polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in Drosophila..” Mech Dev 57, no. 2 (July 1996): 215–27. https://doi.org/10.1016/0925-4773(96)00548-5.
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