Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Pediatric Hem-Onc Fellowship, Pediatrics, Children's Hospital of Philadelphia 2006 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital of Philadelphia 2003 - 2006
  • M.D., University of Medicine and Dentistry of New Jersey 2003
• 

  Duke Appointment History

  • Assistant Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2011 - 2017
  • Medical Instructor in the Department of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2009 - 2011
• 

  Leadership & Clinical Positions at Duke

  • Program Director, Pediatric Fellowship Program
    Clinical Director, Pediatric Hematology/Oncology
    Director, Pediatric Sickle Cell Program
    Director, Inherited Bone Marrow Failure Program
• Research
• 

  Selected Grants

  • PKD Registry AG348-C-008 awarded by Agios Pharmaceuticals, Inc. 2018 - 2026
  • SEG101B221 (Phase 2) awarded by Novartis Pharmaceuticals Corporation 2018 - 2025
  • Eltrombopag for SAA awarded by Novartis Pharmaceuticals Corporation 2017 - 2024
  • AG348-C-011 extension study of adult subjects with Pyruvate Kinase Deficiency awarded by Agios Pharmaceuticals, Inc. 2019 - 2024
  • Phase III study of AG-348 in not regulary transfused adult subjects with Pyruvate kinase deficiency awarded by Agios Pharmaceuticals, Inc. 2018 - 2023
  • An integrated and diverse genomic medicine program for undiagnosed diseases awarded by National Institutes of Health 2014 - 2022
  • Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
  • ITP-APPS (Immune ThrombocytoPenia Association of Platelet Parameters Study) awarded by Boston Children's Hospital 2019 - 2021
  • AN OPEN-LABEL EXTENSION STUDY TO EVALUATE THE SAFETY OF RIVIPANSEL (GMI-1070) IN THE TREATMENT OF ONE OR MORE VASOOCCLUSIVE CRISES IN HOSPITALIZED SUBJECTS WITH SICKLE CELL DISEASE. awarded by Pfizer, Inc. 2016 - 2019
  • CSA - Pfizer 212511 B5201002 Phase 3 Randomized Multicenter Trial awarded by Pfizer, Inc. 2015 - 2019
  • Pediatric Hydroxyurea Phase III Clinical Trial (Baby Hug): Follow-Up Observational Study II awarded by National Institutes of Health 2017 - 2018
  • ICON 1 awarded by Boston Children's Hospital 2013 - 2017
  • PKD Natural Study awarded by Boston Children's Hospital 2014 - 2017
  • TCD With Transfusions Changing to Hydroxyurea (TWITCH) Closeout awarded by Cincinnati Children's Hospital Medical Center 2014 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Rogers, Zora R., Taizo A. Nakano, Timothy S. Olson, Alison A. Bertuch, Winfred Wang, Alfred Gillio, Thomas D. Coates, et al. “Immunosuppressive therapy for pediatric aplastic anemia: a North American Pediatric Aplastic Anemia Consortium study..” Haematologica, April 4, 2019. https://doi.org/10.3324/haematol.2018.206540.
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    • Grace, Rachael F., Kristin A. Shimano, Rukhmi Bhat, Cindy Neunert, James B. Bussel, Robert J. Klaassen, Michele P. Lambert, et al. “Second-line treatments in children with immune thrombocytopenia: Effect on platelet count and patient-centered outcomes..” Am J Hematol, April 3, 2019. https://doi.org/10.1002/ajh.25479.
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    • Beers, Eduard J. van, Stephanie van Straaten, D Holmes Morton, Wilma Barcellini, Stefan W. Eber, Bertil Glader, Hassan M. Yaish, et al. “Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study..” Haematologica 104, no. 2 (February 2019): e51–53. https://doi.org/10.3324/haematol.2018.196295.
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    • Tan, Queenie K-G, Heidi Cope, Rebecca C. Spillmann, Nicholas Stong, Yong-Hui Jiang, Marie T. McDonald, Jennifer A. Rothman, et al. “Further evidence for the involvement of EFL1 in a Shwachman-Diamond-like syndrome and expansion of the phenotypic features..” Cold Spring Harbor Molecular Case Studies 4, no. 5 (October 2018). https://doi.org/10.1101/mcs.a003046.
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    • Grace, Rachael F., Jenny M. Despotovic, Carolyn M. Bennett, James B. Bussel, Michelle Neier, Cindy Neunert, Shelley E. Crary, et al. “Physician decision making in selection of second-line treatments in immune thrombocytopenia in children..” Am J Hematol 93, no. 7 (July 2018): 882–88. https://doi.org/10.1002/ajh.25110.
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    • Borst, Alexandra J., Debra L. Sudan, Laura A. Wang, Michael J. Neuss, Jennifer A. Rothman, and Thomas L. Ortel. “Bleeding and thrombotic complications of pediatric liver transplant..” Pediatr Blood Cancer 65, no. 5 (May 2018). https://doi.org/10.1002/pbc.26955.
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    • Grace, Rachael F., Paola Bianchi, Eduard J. van Beers, Stefan W. Eber, Bertil Glader, Hassan M. Yaish, Jenny M. Despotovic, et al. “Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study..” Blood 131, no. 20 (May 2018): 2183–92. https://doi.org/10.1182/blood-2017-10-810796.
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    • Allen, Taryn M., Lindsay M. Anderson, Jennifer A. Rothman, and Melanie J. Bonner. “[Formula: see text]Executive functioning and health-related quality of life in pediatric sickle cell disease..” Child Neuropsychology : A Journal on Normal and Abnormal Development in Childhood and Adolescence 23, no. 8 (November 2017): 889–906. https://doi.org/10.1080/09297049.2016.1205011.
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    • Cancio, Maria I., Banu Aygun, David H. K. Chui, Jennifer A. Rothman, J Paul Scott, Jeremie H. Estepp, and Jane S. Hankins. “The clinical severity of hemoglobin S/Black (A γδβ)0 -thalassemia..” Pediatric Blood & Cancer 64, no. 11 (November 2017). https://doi.org/10.1002/pbc.26596.
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    • Reiter, Audra, Henry Rice, and Jennifer Rothman. “LONG-TERM CLINICAL AND HEMATOLOGIC OUTCOMES OF SPLENECTOMY IN CHILDREN WITH CONGENITAL HEMOLYTIC ANEMIA.” Pediatric Blood & Cancer 63 (June 1, 2016): S57–S57.
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    • Estepp, Jeremie H., Chiara Melloni, Courtney D. Thornburg, Paweł Wiczling, Zora Rogers, Jennifer A. Rothman, Nancy S. Green, et al. “Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia..” J Clin Pharmacol 56, no. 3 (March 2016): 298–306. https://doi.org/10.1002/jcph.598.
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    • Wang, Hsin-Hsiao Scott, Katherine W. Herbst, Jennifer A. Rothman, Nirmish R. Shah, John S. Wiener, and Jonathan C. Routh. “Trends in Sickle Cell Disease-related Priapism in U.S. Children's Hospitals..” Urology 89 (March 2016): 118–22. https://doi.org/10.1016/j.urology.2015.11.023.
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    • Ware, Russell E., Barry R. Davis, William H. Schultz, R Clark Brown, Banu Aygun, Sharada Sarnaik, Isaac Odame, et al. “Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial..” Lancet 387, no. 10019 (February 13, 2016): 661–70. https://doi.org/10.1016/S0140-6736(15)01041-7.
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    • Luchtman-Jones, Lori, Sara Pressel, Lee Hilliard, R Clark Brown, Mary G. Smith, Alexis A. Thompson, Margaret T. Lee, et al. “Effects of hydroxyurea treatment for patients with hemoglobin SC disease..” American Journal of Hematology 91, no. 2 (February 2016): 238–42. https://doi.org/10.1002/ajh.24255.
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    • Englum, Brian R., Jennifer Rothman, Sarah Leonard, Audra Reiter, Courtney Thornburg, Mary Brindle, Nicola Wright, et al. “Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia..” Journal of Pediatric Surgery 51, no. 1 (January 2016): 122–27. https://doi.org/10.1016/j.jpedsurg.2015.10.028.
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    • Wood, John C., Alan R. Cohen, Sara L. Pressel, Banu Aygun, Hamayun Imran, Lori Luchtman-Jones, Alexis A. Thompson, et al. “Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial..” British Journal of Haematology 172, no. 1 (January 2016): 122–30. https://doi.org/10.1111/bjh.13791.
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    • Allewelt, Heather, Jessica Saricicek, Sachit Patel, and Jennifer Rothman. “BARRIERS TO IMPROVING ANALGESIA FOR VASO-OCCLUSIVE PAIN CRISES IN PEDIATRIC PATIENTS WITH SICKLE CELL DISEASE.” Pediatric Blood & Cancer 62 (June 1, 2015): 40–40.
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    • Rice, Henry E., Brian R. Englum, Jennifer Rothman, Sarah Leonard, Audra Reiter, Courtney Thornburg, Mary Brindle, et al. “Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry..” American Journal of Hematology 90, no. 3 (March 2015): 187–92. https://doi.org/10.1002/ajh.23888.
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    • Mize, Lindsay, Shelly Burgett, Julia Xu, Jennifer Rothman, and Nirmish Shah. “The Use of Chronic Transfusions in Sickle Cell Disease for Non-Stroke Related Indications.” Blood 124, no. 21 (December 6, 2014).
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    • Zimmerman, Sarah P., Jennifer A. Rothman, Jessica L. Hansen, Molly M. Rusin, Matthew A. Bertone, and Harvey J. Hamrick. “Systemic loxoscelism in a nonendemic area: a diagnostic challenge for the unsuspecting physician..” Clinical Pediatrics 53, no. 11 (October 2014): 1098–1100. https://doi.org/10.1177/0009922813512419.
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    • Leonard, Sarah, Jennifer Rothman, Nirmish Shah, Courtney Thornburg, and Henry Rice. “CURRENT PRACTICE PATTERNS FOR PARTIAL VERSUS TOTAL SPLENECTOMY IN PEDIATRIC PATIENTS WITH CONGENITAL HEMOLYTIC ANEMIA.” Pediatric Blood & Cancer 61 (May 1, 2014): S92–S92.
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    • Mouttalib, Sofia, Henry E. Rice, Denise Snyder, Justin S. Levens, Audra Reiter, Pauline Soler, Jennifer A. Rothman, and Courtney D. Thornburg. “Evaluation of partial and total splenectomy in children with sickle cell disease using an Internet-based registry..” Pediatric Blood & Cancer 59, no. 1 (July 2012): 100–104. https://doi.org/10.1002/pbc.24057.
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    • Shah, Nirmish, Daniel Landi, Radhika Shah, Jennifer Rothman, Laura M. De Castro, and Courtney D. Thornburg. “Complications of implantable venous access devices in patients with sickle cell disease..” American Journal of Hematology 87, no. 2 (February 2012): 224–26. https://doi.org/10.1002/ajh.22230.
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    • Rothman, Jennifer A., Rupali Das, David T. Teachey, Michele E. Paessler, and Kim E. Nichols. “Rapamycin does not control hemophagocytic lymphohistiocytosis in LCMV-infected perforin-deficient mice..” Pediatric Blood & Cancer 57, no. 7 (December 2011): 1239–43. https://doi.org/10.1002/pbc.23226.
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    • Mouttalib, Sofia, Denise Snyder, Justin Levens, Pauline Soler, Jennifer Rothman, Courtney Thornburg, and Henry Rice. “USE OF INTERNET-BASED REGISTRY FOR EVALUATION OF PARTIAL AND TOTAL SPLENECTOMY IN SICKLE CELL DISEASE.” Pediatric Blood & Cancer 56, no. 6 (June 1, 2011): 911–911.
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    • Talaat, Kawsar R., Jennifer A. Rothman, Jeffrey I. Cohen, Mariarita Santi, John K. Choi, Miguel Guzman, Robert Zimmerman, et al. “Lymphocytic vasculitis involving the central nervous system occurs in patients with X-linked lymphoproliferative disease in the absence of Epstein-Barr virus infection..” Pediatric Blood & Cancer 53, no. 6 (December 2009): 1120–23. https://doi.org/10.1002/pbc.22185.
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    • Impens, A. J., J. Rothman, E. Schiopu, J. C. Cole, J. Dang, N. Gendrano, R. C. Rosen, and J. R. Seibold. “Sexual activity and functioning in female scleroderma patients.” Clinical and Experimental Rheumatology 27, no. 3 SUPPL. 54 (November 9, 2009).
    • Schiopu, Elena, Vivien M. Hsu, Ann J. Impens, Jennifer A. Rothman, Deborah A. McCloskey, Julianne E. Wilson, Kristine Phillips, and James R. Seibold. “Randomized placebo-controlled crossover trial of tadalafil in Raynaud's phenomenon secondary to systemic sclerosis..” The Journal of Rheumatology 36, no. 10 (October 2009): 2264–68. https://doi.org/10.3899/jrheum.090270.
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    • Impens, A. J., J. Rothman, E. Schiopu, J. C. Cole, J. Dang, N. Gendrano, R. C. Rosen, and J. R. Seibold. “Sexual activity and functioning in female scleroderma patients..” Clinical and Experimental Rheumatology 27, no. 3 Suppl 54 (May 2009): 38–43.
    • Nunez-Cruz, Selene, WC Janice Yeo, Jennifer Rothman, Priti Ojha, Hamid Bassiri, Marisa Juntilla, Dominique Davidson, André Veillette, Gary A. Koretzky, and Kim E. Nichols. “Differential requirement for the SAP-Fyn interaction during NK T cell development and function..” Journal of Immunology (Baltimore, Md. : 1950) 181, no. 4 (August 2008): 2311–20. https://doi.org/10.4049/jimmunol.181.4.2311.
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    • Rao, Aarati, Jennifer Rothman, and Kim E. Nichols. “Genetic testing and tumor surveillance for children with cancer predisposition syndromes..” Current Opinion in Pediatrics 20, no. 1 (February 2008): 1–7. https://doi.org/10.1097/mop.0b013e3282f4249a.
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    • Bassiri, Hamid, W. C. Janice Yeo, Jennifer Rothman, Gary A. Koretzky, and Kim E. Nichols. “X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses..” Immunologic Research 42, no. 1–3 (January 2008): 145–59. https://doi.org/10.1007/s12026-008-8048-7.
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  • Book Sections

    • Greiner, R. J., S. Peterson-Carmichael, J. A. Rothman, K. W. Gow, R. F. Tamburro, and R. Barfield. “Care of the oncology patient in the picu.” In Pediatric Critical Care Medicine: Volume 3: Gastroenterological, Endocrine, Renal, Hematologic, Oncologic and Immune Systems, 343–61, 2014. https://doi.org/10.1007/978-1-4471-6416-6_24.
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  • Conference Papers

    • Van Beers, Eduard J., Kevin H. M. Kuo, D Holmes Morton, Wilma Barcellini, Stefan W. Eber, Bertil Glader, Hassan M. Yaish, et al. “Health Related Quality of Life and Fatigue in Patients with Pyruvate Kinase Deficiency.” In Blood, Vol. 132. AMER SOC HEMATOLOGY, 2018. https://doi.org/10.1182/blood-2018-99-113206.
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    • Grace, Rachael F., Robert J. Klaassen, Jennifer A. Rothman, Kerry Hege, Ellis J. Neufeld, Carolyn M. Bennett, Michele Lambert, et al. “Clinical Characteristics and Quality of Life of Children with ITP Starting Second Line Treatments: Data from the ITP Consortium of North America ICON1 Study.” In Blood, Vol. 128. AMER SOC HEMATOLOGY, 2016.
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    • Lambert, Michele P., Rachael F. Grace, Cindy Neunert, Jenny M. Despotovic, Rukhmi Bhat, Yves D. Pastore, George R. Buchanan, et al. “Physician Factors Determining Treatment Decisions in Selecting Second Line Agents for Pediatric ITP.” In Blood, Vol. 128. AMER SOC HEMATOLOGY, 2016.
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    • Leraas, Harold J., Jina Kim, Zhifei Sun, Uttara P. Nag, Brian D. Ezekian, Reed W. Kamyszek, Brian C. Gulack, et al. “Postoperative Venous Thromboembolism in Children Is Increased in Setting of Cancer or Infection.” In Blood, Vol. 128. AMER SOC HEMATOLOGY, 2016.
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    • Ware, Russell E., Adam Lane, William H. Schultz, Hamayun Imran, Margaret T. Lee, Matthew M. Heeney, Clark Brown, et al. “Variation in Serial TCD Velocity Measurements in the TCD with Transfusions Changing to Hydroxyurea (TWiTCH) Trial.” In Blood, Vol. 128. AMER SOC HEMATOLOGY, 2016.
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    • Bianchi, Paola, Elisa Fermo, Kimberly Lezon-Geyda, Patrick G. Gallagher, D Holmes Morton, Wilma Barcellini, Bertil Glader, et al. “Molecular Characterization of 140 Patients in the Pyruvate Kinase Deficiency (PKD) Natural History Study (NHS): Report of 20 New Variants.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.
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    • Chonat, Satheesh, Mary Risinger, Neha Dagaonkar, Tamara Maghathe, Jennifer Rothman, Jessica Connor, Karen Kalinyak, Amber H. Begtrup, Kejian Zhang, and Theodosia A. Kalfa. “The Spectrum of Alpha-Spectrin Associated Hereditary Spherocytosis.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.
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    • Grace, Rachael F., D Holmes Morton, Wilma Barcellini, Stefan W. Eber, Jenny M. Depsotovic, Christine M. Knoll, Hassan M. Yaish, et al. “The Phenotypic Spectrum of Pyruvate Kinase Deficiency (PKD) from the PKD Natural History Study (NHS): Description of Four Severity Groups By Anemia Status.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.
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    • Ware, Russell E., Barry R. Davis, William H. Schultz, Clark Brown, Banu Aygun, Sharada A. Sarnaik, Isaac Odame, et al. “TCD with Transfusions Changing to Hydroxyurea (TWiTCH): Hydroxyurea Therapy As an Alternative to Transfusions for Primary Stroke Prevention in Children with Sickle Cell Anemia.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.
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    • Grace, R., W. Barcellini, S. Eber, J. Kunz, J. Despotovic, A. Thompson, D. H. Morton, et al. “CATEGORIZATION OF CLINICAL SEVERITY IN PYRUVATE KINASE DEFICIENCY (PKD) IN AN INTERNATIONAL, OBSERVATIONAL COHORT.” In Haematologica, 100:130–31. FERRATA STORTI FOUNDATION, 2015.
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    • Morton, D. H., C. Knoll, J. Rothman, B. Glader, E. Neufeld, W. Barcellini, S. Eber, et al. “THE CLINICAL FEATURES AND TREATMENT OF IRON OVERLOAD IN PYRUVATE KINASE DEFICIENCY (PKD): DATA FROM THE PKD NATURAL HISTORY STUDY (NHS).” In Haematologica, 100:588–588. FERRATA STORTI FOUNDATION, 2015.
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    • Willen, Shaina, Nirmish Shah, Courtney Thornburg, and Jennifer Rothman. “Timing of the Initiation of Hydroxyurea and Hematologic Outcomes in Patients with Sickle Cell Disease (SCD).” In Blood, Vol. 120. AMER SOC HEMATOLOGY, 2012.
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    • Rothman, Jennifer, Shelly Burgett, Russell E. Ware, and Courtney Thornburg. “Hydroxyurea Reduces Conversion From Conditional to Abnormal TCD Velocities In Children with Sickle Cell Anemia (SCA).” In Blood, 116:123–24. AMER SOC HEMATOLOGY, 2010.
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    • Shah, Nirmish, Daniel Landi, Radhika Shah, Jennifer Rothman, and Courtney Thornburg. “Complications of Implantable Venous Access Devices In Patients with Sickle Cell Disease.” In Blood, 116:692–692. AMER SOC HEMATOLOGY, 2010.
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Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.