Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Pediatric Hem-Onc Fellowship, Pediatrics, Children's Hospital of Philadelphia 2006 - 2009
  • Pediatric Residency, Pediatrics, Children's Hospital of Philadelphia 2003 - 2006
  • M.D., University of Medicine and Dentistry of New Jersey 2003
• 

  Duke Appointment History

  • Assistant Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2011 - 2017
  • Medical Instructor in the Department of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2009 - 2011
• 

  Leadership & Clinical Positions at Duke

  • Program Director, Pediatric Fellowship Program
    Clinical Director, Pediatric Hematology/Oncology
    Director, Pediatric Sickle Cell Program
    Director, Inherited Bone Marrow Failure Program
• Research
• 

  Selected Grants

  • PKD Registry AG348-C-008 2018 - 2026
  • SEG101B221 (Phase 2) 2018 - 2025
  • Eltrombopag for SAA 2017 - 2024
  • AG348-C-011 extension study of adult subjects with Pyruvate Kinase Deficiency 2019 - 2024
  • Phase III study of AG-348 in not regulary transfused adult subjects with Pyruvate kinase deficiency 2018 - 2023
  • An integrated and diverse genomic medicine program for undiagnosed diseases awarded by National Institutes of Health 2014 - 2022
  • A Phase 3 Study of Eltrombopag vs. Standard First-Line Management for Newly Diagnosed Immune Thrombocytopenia (ITP) in Children 2019 - 2021
  • Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
  • ITP-APPS (Immune ThrombocytoPenia Association of Platelet Parameters Study) 2019 - 2021
  • AN OPEN-LABEL EXTENSION STUDY TO EVALUATE THE SAFETY OF RIVIPANSEL (GMI-1070) IN THE TREATMENT OF ONE OR MORE VASOOCCLUSIVE CRISES IN HOSPITALIZED SUBJECTS WITH SICKLE CELL DISEASE. 2016 - 2020
  • CSA - Pfizer 212511 B5201002 Phase 3 Randomized Multicenter Trial 2015 - 2020
  • Pediatric Hydroxyurea Phase III Clinical Trial (Baby Hug): Follow-Up Observational Study II awarded by National Institutes of Health 2017 - 2018
  • ICON 1 2013 - 2017
  • PKD Natural Study 2014 - 2017
  • TCD With Transfusions Changing to Hydroxyurea (TWITCH) Closeout 2014 - 2015
• 

  External Relationships

  • Agios Pharmaceuticals
  • Novartis
  • Pfizer Inc.
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Rogers, Zora R., Taizo A. Nakano, Timothy S. Olson, Alison A. Bertuch, Winfred Wang, Alfred Gillio, Thomas D. Coates, et al. “Immunosuppressive therapy for pediatric aplastic anemia: a North American Pediatric Aplastic Anemia Consortium study.” Haematologica 104, no. 10 (October 2019): 1974–83. https://doi.org/10.3324/haematol.2018.206540.
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    • Grace, Rachael F., Kristin A. Shimano, Rukhmi Bhat, Cindy Neunert, James B. Bussel, Robert J. Klaassen, Michele P. Lambert, et al. “Second-line treatments in children with immune thrombocytopenia: Effect on platelet count and patient-centered outcomes.” Am J Hematol 94, no. 7 (July 2019): 741–50. https://doi.org/10.1002/ajh.25479.
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    • Gallagher, Patrick G., Yelena Maksimova, Kimberly Lezon-Geyda, Peter E. Newburger, Desiree Medeiros, Robin D. Hanson, Jennifer Rothman, et al. “Aberrant splicing contributes to severe α-spectrin-linked congenital hemolytic anemia.” J Clin Invest 129, no. 7 (April 30, 2019): 2878–87. https://doi.org/10.1172/JCI127195.
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    • Beers, Eduard J. van, Stephanie van Straaten, D Holmes Morton, Wilma Barcellini, Stefan W. Eber, Bertil Glader, Hassan M. Yaish, et al. “Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study.” Haematologica 104, no. 2 (February 2019): e51–53. https://doi.org/10.3324/haematol.2018.196295.
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    • Allen, T. M., L. M. Anderson, S. M. Brotkin, J. A. Rothman, and M. J. Bonner. “Computerized Cognitive Training in Pediatric Sickle Cell Disease: A Randomized Controlled Pilot Study.” Clinical Practice in Pediatric Psychology, January 1, 2019. https://doi.org/10.1037/cpp0000313.
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    • Chonat, Satheesh, Mary Risinger, Haripriya Sakthivel, Omar Niss, Jennifer A. Rothman, Loan Hsieh, Stella T. Chou, et al. “Corrigendum: The Spectrum of SPTA1-Associated Hereditary Spherocytosis.” Front Physiol 10 (2019): 1331. https://doi.org/10.3389/fphys.2019.01331.
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    • Tan, Queenie K-G, Heidi Cope, Rebecca C. Spillmann, Nicholas Stong, Yong-Hui Jiang, Marie T. McDonald, Jennifer A. Rothman, et al. “Further evidence for the involvement of EFL1 in a Shwachman-Diamond-like syndrome and expansion of the phenotypic features.” Cold Spring Harb Mol Case Stud 4, no. 5 (October 2018). https://doi.org/10.1101/mcs.a003046.
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    • Grace, Rachael F., Jenny M. Despotovic, Carolyn M. Bennett, James B. Bussel, Michelle Neier, Cindy Neunert, Shelley E. Crary, et al. “Physician decision making in selection of second-line treatments in immune thrombocytopenia in children.” Am J Hematol 93, no. 7 (July 2018): 882–88. https://doi.org/10.1002/ajh.25110.
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    • Grace, Rachael F., Paola Bianchi, Eduard J. van Beers, Stefan W. Eber, Bertil Glader, Hassan M. Yaish, Jenny M. Despotovic, et al. “Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study.” Blood 131, no. 20 (May 17, 2018): 2183–92. https://doi.org/10.1182/blood-2017-10-810796.
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    • Borst, Alexandra J., Debra L. Sudan, Laura A. Wang, Michael J. Neuss, Jennifer A. Rothman, and Thomas L. Ortel. “Bleeding and thrombotic complications of pediatric liver transplant.” Pediatr Blood Cancer 65, no. 5 (May 2018): e26955. https://doi.org/10.1002/pbc.26955.
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    • Allen, Taryn M., Lindsay M. Anderson, Jennifer A. Rothman, and Melanie J. Bonner. “[Formula: see text]Executive functioning and health-related quality of life in pediatric sickle cell disease.” Child Neuropsychol 23, no. 8 (November 2017): 889–906. https://doi.org/10.1080/09297049.2016.1205011.
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    • Cancio, Maria I., Banu Aygun, David H. K. Chui, Jennifer A. Rothman, J Paul Scott, Jeremie H. Estepp, and Jane S. Hankins. “The clinical severity of hemoglobin S/Black (A γδβ)0 -thalassemia.” Pediatr Blood Cancer 64, no. 11 (November 2017). https://doi.org/10.1002/pbc.26596.
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    • Reiter, Audra, Henry Rice, and Jennifer Rothman. “LONG-TERM CLINICAL AND HEMATOLOGIC OUTCOMES OF SPLENECTOMY IN CHILDREN WITH CONGENITAL HEMOLYTIC ANEMIA.” Pediatric Blood & Cancer 63 (June 1, 2016): S57–S57.
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    • Estepp, Jeremie H., Chiara Melloni, Courtney D. Thornburg, Paweł Wiczling, Zora Rogers, Jennifer A. Rothman, Nancy S. Green, et al. “Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia.” J Clin Pharmacol 56, no. 3 (March 2016): 298–306. https://doi.org/10.1002/jcph.598.
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    • Wang, Hsin-Hsiao Scott, Katherine W. Herbst, Jennifer A. Rothman, Nirmish R. Shah, John S. Wiener, and Jonathan C. Routh. “Trends in Sickle Cell Disease-related Priapism in U.S. Children's Hospitals.” Urology 89 (March 2016): 118–22. https://doi.org/10.1016/j.urology.2015.11.023.
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    • Ware, Russell E., Barry R. Davis, William H. Schultz, R Clark Brown, Banu Aygun, Sharada Sarnaik, Isaac Odame, et al. “Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial.” Lancet 387, no. 10019 (February 13, 2016): 661–70. https://doi.org/10.1016/S0140-6736(15)01041-7.
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    • Luchtman-Jones, Lori, Sara Pressel, Lee Hilliard, R Clark Brown, Mary G. Smith, Alexis A. Thompson, Margaret T. Lee, et al. “Effects of hydroxyurea treatment for patients with hemoglobin SC disease.” Am J Hematol 91, no. 2 (February 2016): 238–42. https://doi.org/10.1002/ajh.24255.
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    • Englum, Brian R., Jennifer Rothman, Sarah Leonard, Audra Reiter, Courtney Thornburg, Mary Brindle, Nicola Wright, et al. “Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia.” J Pediatr Surg 51, no. 1 (January 2016): 122–27. https://doi.org/10.1016/j.jpedsurg.2015.10.028.
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    • Wood, John C., Alan R. Cohen, Sara L. Pressel, Banu Aygun, Hamayun Imran, Lori Luchtman-Jones, Alexis A. Thompson, et al. “Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial.” British Journal of Haematology 172, no. 1 (January 2016): 122–30. https://doi.org/10.1111/bjh.13791.
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    • Allewelt, Heather, Jessica Saricicek, Sachit Patel, and Jennifer Rothman. “BARRIERS TO IMPROVING ANALGESIA FOR VASO-OCCLUSIVE PAIN CRISES IN PEDIATRIC PATIENTS WITH SICKLE CELL DISEASE.” Pediatric Blood & Cancer 62 (June 1, 2015): 40–40.
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    • Rice, Henry E., Brian R. Englum, Jennifer Rothman, Sarah Leonard, Audra Reiter, Courtney Thornburg, Mary Brindle, et al. “Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry.” Am J Hematol 90, no. 3 (March 2015): 187–92. https://doi.org/10.1002/ajh.23888.
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    • Mize, Lindsay, Shelly Burgett, Julia Xu, Jennifer Rothman, and Nirmish Shah. “The Use of Chronic Transfusions in Sickle Cell Disease for Non-Stroke Related Indications.” Blood 124, no. 21 (December 6, 2014).
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    • Zimmerman, Sarah P., Jennifer A. Rothman, Jessica L. Hansen, Molly M. Rusin, Matthew A. Bertone, and Harvey J. Hamrick. “Systemic loxoscelism in a nonendemic area: a diagnostic challenge for the unsuspecting physician.” Clin Pediatr (Phila) 53, no. 11 (October 2014): 1098–1100. https://doi.org/10.1177/0009922813512419.
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    • Leonard, Sarah, Jennifer Rothman, Nirmish Shah, Courtney Thornburg, and Henry Rice. “CURRENT PRACTICE PATTERNS FOR PARTIAL VERSUS TOTAL SPLENECTOMY IN PEDIATRIC PATIENTS WITH CONGENITAL HEMOLYTIC ANEMIA.” Pediatric Blood & Cancer 61 (May 1, 2014): S92–S92.
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    • Mouttalib, Sofia, Henry E. Rice, Denise Snyder, Justin S. Levens, Audra Reiter, Pauline Soler, Jennifer A. Rothman, and Courtney D. Thornburg. “Evaluation of partial and total splenectomy in children with sickle cell disease using an Internet-based registry.” Pediatr Blood Cancer 59, no. 1 (July 15, 2012): 100–104. https://doi.org/10.1002/pbc.24057.
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    • Shah, Nirmish, Daniel Landi, Radhika Shah, Jennifer Rothman, Laura M. De Castro, and Courtney D. Thornburg. “Complications of implantable venous access devices in patients with sickle cell disease.” Am J Hematol 87, no. 2 (February 2012): 224–26. https://doi.org/10.1002/ajh.22230.
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    • Rothman, Jennifer A., Rupali Das, David T. Teachey, Michele E. Paessler, and Kim E. Nichols. “Rapamycin does not control hemophagocytic lymphohistiocytosis in LCMV-infected perforin-deficient mice.” Pediatr Blood Cancer 57, no. 7 (December 15, 2011): 1239–43. https://doi.org/10.1002/pbc.23226.
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    • Mouttalib, Sofia, Denise Snyder, Justin Levens, Pauline Soler, Jennifer Rothman, Courtney Thornburg, and Henry Rice. “USE OF INTERNET-BASED REGISTRY FOR EVALUATION OF PARTIAL AND TOTAL SPLENECTOMY IN SICKLE CELL DISEASE.” Pediatric Blood & Cancer 56, no. 6 (June 1, 2011): 911–911.
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    • Talaat, Kawsar R., Jennifer A. Rothman, Jeffrey I. Cohen, Mariarita Santi, John K. Choi, Miguel Guzman, Robert Zimmerman, et al. “Lymphocytic vasculitis involving the central nervous system occurs in patients with X-linked lymphoproliferative disease in the absence of Epstein-Barr virus infection.” Pediatr Blood Cancer 53, no. 6 (December 2009): 1120–23. https://doi.org/10.1002/pbc.22185.
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    • Impens, A. J., J. Rothman, E. Schiopu, J. C. Cole, J. Dang, N. Gendrano, R. C. Rosen, and J. R. Seibold. “Sexual activity and functioning in female scleroderma patients.” Clinical and Experimental Rheumatology 27, no. 3 SUPPL. 54 (November 9, 2009).
    • Schiopu, Elena, Vivien M. Hsu, Ann J. Impens, Jennifer A. Rothman, Deborah A. McCloskey, Julianne E. Wilson, Kristine Phillips, and James R. Seibold. “Randomized placebo-controlled crossover trial of tadalafil in Raynaud's phenomenon secondary to systemic sclerosis.” J Rheumatol 36, no. 10 (October 2009): 2264–68. https://doi.org/10.3899/jrheum.090270.
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    • Impens, A. J., J. Rothman, E. Schiopu, J. C. Cole, J. Dang, N. Gendrano, R. C. Rosen, and J. R. Seibold. “Sexual activity and functioning in female scleroderma patients.” Clin Exp Rheumatol 27, no. 3 Suppl 54 (May 2009): 38–43.
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    • Nunez-Cruz, Selene, WC Janice Yeo, Jennifer Rothman, Priti Ojha, Hamid Bassiri, Marisa Juntilla, Dominique Davidson, André Veillette, Gary A. Koretzky, and Kim E. Nichols. “Differential requirement for the SAP-Fyn interaction during NK T cell development and function.” J Immunol 181, no. 4 (August 15, 2008): 2311–20. https://doi.org/10.4049/jimmunol.181.4.2311.
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    • Rao, Aarati, Jennifer Rothman, and Kim E. Nichols. “Genetic testing and tumor surveillance for children with cancer predisposition syndromes.” Curr Opin Pediatr 20, no. 1 (February 2008): 1–7. https://doi.org/10.1097/MOP.0b013e3282f4249a.
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    • Bassiri, Hamid, W. C. Janice Yeo, Jennifer Rothman, Gary A. Koretzky, and Kim E. Nichols. “X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses.” Immunol Res 42, no. 1–3 (2008): 145–59. https://doi.org/10.1007/s12026-008-8048-7.
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    • Chonat, Satheesh, Mary Risinger, Haripriya Sakthivel, Omar Niss, Jennifer A. Rothman, Loan Hsieh, Stella T. Chou, et al. “The Spectrum of SPTA1-Associated Hereditary Spherocytosis.” Frontiers in Physiology 10 (n.d.). https://doi.org/10.3389/fphys.2019.00815.
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  • Book Sections

    • Greiner, R. J., S. Peterson-Carmichael, J. A. Rothman, K. W. Gow, R. F. Tamburro, and R. Barfield. “Care of the oncology patient in the picu.” In Pediatric Critical Care Medicine: Volume 3: Gastroenterological, Endocrine, Renal, Hematologic, Oncologic and Immune Systems, 343–61, 2014. https://doi.org/10.1007/978-1-4471-6416-6_24.
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  • Conference Papers

    • Nannes, Caleb, Jennifer Rothman, Addison Gross, and Susan Kreissman. “IMPROVING NUTRITIONAL SUPPORT FOR PEDIATRIC HEMATOLOGY & ONCOLOGY PATIENTS.” In Pediatric Blood & Cancer, Vol. 66. WILEY, 2019.
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    • Chonat, Satheesh, Mary Risinger, Haripriya Sakthivel, Omar Niss, Jennifer A. Rothman, Loan Hsieh, Stella T. Chou, et al. “The Spectrum of SPTA1-Associated Hereditary Spherocytosis.” In Front Physiol, 10:815, 2019. https://doi.org/10.3389/fphys.2019.00815.
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    • Van Beers, Eduard J., Kevin H. M. Kuo, D Holmes Morton, Wilma Barcellini, Stefan W. Eber, Bertil Glader, Hassan M. Yaish, et al. “Health Related Quality of Life and Fatigue in Patients with Pyruvate Kinase Deficiency.” In Blood, 132:4807–4807. American Society of Hematology, 2018. https://doi.org/10.1182/blood-2018-99-113206.
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    • Grace, Rachael F., Robert J. Klaassen, Jennifer A. Rothman, Kerry Hege, Ellis J. Neufeld, Carolyn M. Bennett, Michele Lambert, et al. “Clinical Characteristics and Quality of Life of Children with ITP Starting Second Line Treatments: Data from the ITP Consortium of North America ICON1 Study.” In Blood, 128:249–249. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.249.249.
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    • Lambert, Michele P., Rachael F. Grace, Cindy Neunert, Jenny M. Despotovic, Rukhmi Bhat, Yves D. Pastore, George R. Buchanan, et al. “Physician Factors Determining Treatment Decisions in Selecting Second Line Agents for Pediatric ITP.” In Blood, 128:1008–1008. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.1008.1008.
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    • Leraas, Harold J., Jina Kim, Zhifei Sun, Uttara P. Nag, Brian D. Ezekian, Reed W. Kamyszek, Brian C. Gulack, et al. “Postoperative Venous Thromboembolism in Children Is Increased in Setting of Cancer or Infection.” In Blood, 128:2391–2391. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.2391.2391.
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    • Ware, Russell E., Adam Lane, William H. Schultz, Hamayun Imran, Margaret T. Lee, Matthew M. Heeney, Clark Brown, et al. “Variation in Serial TCD Velocity Measurements in the TCD with Transfusions Changing to Hydroxyurea (TWiTCH) Trial.” In Blood, 128:1019–1019. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.1019.1019.
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    • Bianchi, Paola, Elisa Fermo, Kimberly Lezon-Geyda, Patrick G. Gallagher, D Holmes Morton, Wilma Barcellini, Bertil Glader, et al. “Molecular Characterization of 140 Patients in the Pyruvate Kinase Deficiency (PKD) Natural History Study (NHS): Report of 20 New Variants.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.
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    • Grace, Rachael F., D Holmes Morton, Wilma Barcellini, Stefan W. Eber, Jenny M. Depsotovic, Christine M. Knoll, Hassan M. Yaish, et al. “The Phenotypic Spectrum of Pyruvate Kinase Deficiency (PKD) from the PKD Natural History Study (NHS): Description of Four Severity Groups By Anemia Status.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.
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    • Ware, Russell E., Barry R. Davis, William H. Schultz, Clark Brown, Banu Aygun, Sharada A. Sarnaik, Isaac Odame, et al. “TCD with Transfusions Changing to Hydroxyurea (TWiTCH): Hydroxyurea Therapy As an Alternative to Transfusions for Primary Stroke Prevention in Children with Sickle Cell Anemia.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.
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    • Grace, R., W. Barcellini, S. Eber, J. Kunz, J. Despotovic, A. Thompson, D. H. Morton, et al. “CATEGORIZATION OF CLINICAL SEVERITY IN PYRUVATE KINASE DEFICIENCY (PKD) IN AN INTERNATIONAL, OBSERVATIONAL COHORT.” In Haematologica, 100:130–31. FERRATA STORTI FOUNDATION, 2015.
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    • Morton, D. H., C. Knoll, J. Rothman, B. Glader, E. Neufeld, W. Barcellini, S. Eber, et al. “THE CLINICAL FEATURES AND TREATMENT OF IRON OVERLOAD IN PYRUVATE KINASE DEFICIENCY (PKD): DATA FROM THE PKD NATURAL HISTORY STUDY (NHS).” In Haematologica, 100:588–588. FERRATA STORTI FOUNDATION, 2015.
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    • Willen, Shaina, Nirmish Shah, Courtney Thornburg, and Jennifer Rothman. “Timing of the Initiation of Hydroxyurea and Hematologic Outcomes in Patients with Sickle Cell Disease (SCD).” In Blood, 120:1004–1004. American Society of Hematology, 2012. https://doi.org/10.1182/blood.v120.21.1004.1004.
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    • Rothman, Jennifer, Shelly Burgett, Russell E. Ware, and Courtney Thornburg. “Hydroxyurea Reduces Conversion From Conditional to Abnormal TCD Velocities In Children with Sickle Cell Anemia (SCA).” In Blood, 116:123–24. AMER SOC HEMATOLOGY, 2010.
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    • Shah, Neil, Hagop Kantarjian, Andreas Hochhaus, Jorge E. Cortes, M Brigid Bradley-Garelik, Chao Zhu, and Michele Baccarani. “Dasatinib Versus Imatinib In Patients with Newly Diagnosed Chronic Myeloid Leukemia In Chronic Phase (CML-CP) In the DASISION Trial: 18-Month Follow-up.” In Blood, 116:206–206. American Society of Hematology, 2010. https://doi.org/10.1182/blood.v116.21.206.206.
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