Scholars@Duke
Jessica Lynne Poisson

Jessica Lynne Poisson

Associate Professor of Pathology
Pathology
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Selected Publications

Acute pulmonary injury in hematology patients supported with pathogen-reduced and conventional platelet components.

Journal Article Blood Adv · May 14, 2024 Patients treated with antineoplastic therapy often develop thrombocytopenia requiring platelet transfusion, which has potential to exacerbate pulmonary injury. This study tested the hypothesis that amotosalen-UVA pathogen-reduced platelet components (PRPCs ... Full text Link to item Cite

Increased red blood cell alloimmunization rates in transfused aplastic anemia and myelofibrosis patients.

Journal Article Transfusion · October 2023 BACKGROUND: Red blood cell (RBC) alloimmunization (AI) is a well-known complication of RBC transfusions, which results in the formation of alloantibodies to non-self antigens on donor RBCs, putting patients at risk of transfusion-related complications. The ... Full text Link to item Cite

Development of New Donor-Specific and Human Leukocyte Antigen Antibodies After Transfusion in Adult Lung Transplantation.

Journal Article J Cardiothorac Vasc Anesth · September 2023 OBJECTIVES: The development of new human leukocyte antigens (HLAs) and donor-specific antibodies (DSAs) in patients are associated with worse outcomes following lung transplantation. The authors aimed to examine the relationship between blood product trans ... Full text Open Access Link to item Cite

Transfusion of ABO-group identical red blood cells following uncrossmatched transfusion does not lead to higher mortality in civilian trauma patients.

Journal Article Transfusion · May 2023 BACKGROUND: Questions persist about the safety of switching non-group O recipients of group O uncrossmatched red blood cells (RBC) or low titer group O whole blood (LTOWB) to ABO-identical RBCs during their resuscitation. METHODS: The database of an earlie ... Full text Link to item Cite

Massive Transfusion Protocol Adherence: Relationship to Trauma Patient Outcomes.

Journal Article J Trauma Nurs · May 2023 BACKGROUND: Ongoing evaluation of massive transfusion protocol adherence is critical to ensure better trauma patient outcomes. OBJECTIVE: This quality improvement initiative aimed to determine provider adherence to a recently revised massive transfusion pr ... Full text Link to item Cite

The importance of patient blood management for patients, providers and the public

Journal Article Annals of Blood · January 1, 2023 Patient blood management (PBM) is a systematic and multidisciplinary approach to provide higher-quality care to patients who have traditionally received blood transfusions as a part of their therapy. It is an alternative approach to the conventional transf ... Full text Cite

Hospital red blood cell and platelet supply and utilization from March to December of the first year of the COVID-19 pandemic: The BEST collaborative study.

Journal Article Transfusion · August 2022 BACKGROUND: At the start of the coronavirus disease 2019 (COVID-19) pandemic, widespread blood shortages were anticipated. We sought to determine how hospital blood supply and blood utilization were affected by the first wave of COVID-19. STUDY DESIGN AND ... Full text Link to item Cite

Comparative risk of pulmonary adverse events with transfusion of pathogen reduced and conventional platelet components.

Journal Article Transfusion · July 2022 BACKGROUND: Platelet transfusion carries risk of transfusion-transmitted infection (TTI). Pathogen reduction of platelet components (PRPC) is designed to reduce TTI. Pulmonary adverse events (AEs), including transfusion-related acute lung injury and acute ... Full text Link to item Cite

Blood product transfusion and lung transplant outcomes: A systematic review.

Journal Article Clin Transplant · October 2021 The perioperative transfusion of blood products has long been linked to development of acute lung injury and associated with mortality across both medical and surgical patient populations.1,2 The need for blood product transfusion during and after lung tra ... Full text Link to item Cite

The Association of Increased FFP:RBC Transfusion Ratio to Primary Graft Dysfunction in Bleeding Lung Transplantation Patients.

Journal Article J Cardiothorac Vasc Anesth · November 2020 OBJECTIVES: Lung transplantation is associated with a significant risk of needed transfusion. Although algorithm-based transfusion strategies that promote a high fresh frozen plasma:red blood cells (FFP:RBC) ratio have reduced overall blood product require ... Full text Link to item Cite

Transfusion of blood components containing ABO-incompatible plasma does not lead to higher mortality in civilian trauma patients.

Journal Article Transfusion · November 2020 BACKGROUND: This study investigated the effect on mortality of transfusing ABO-incompatible plasma from all sources during trauma resuscitation. METHODS: Demographic, transfusion, and survival data were retrospectively extracted on civilian trauma patients ... Full text Link to item Cite

The effect of pathogen inactivation on cryoprecipitate: a functional and quantitative evaluation.

Journal Article Blood transfusion = Trasfusione del sangue · November 2020 BackgroundAs a pooled donor blood product, cryoprecipitate (cryo) carries risks of pathogen transmission. Pathogen inactivation (PI) improves the safety of cryoprecipitate, but its effects on haemostatic properties remain unclear. This study inves ... Full text Cite

Comparison of the platelet activation status of single-donor platelets obtained with two different cell separator technologies.

Journal Article Transfusion · September 2020 BACKGROUND: The microparticle content (MP%) of apheresis platelets-a marker of platelet activation-is influenced by donor factors and by external stressors during collection and storage. This study assessed the impact of apheresis technology and other fact ... Full text Link to item Cite

Anticoagulation Strategies in the Perioperative Period for Lung Transplant.

Journal Article Ann Thorac Surg · July 2020 Patients who are undergoing lung transplantation may require systemic anticoagulation in the perioperative period for various indications at the time of the procedure. Four-factor prothrombin complex concentrate has been approved in the United States to re ... Full text Link to item Cite

Rejuvenation solution as an adjunct cold storage solution maintains physiological haemoglobin oxygen affinity during early-storage period of red blood cells.

Journal Article Vox Sang · July 2020 BACKGROUND: Red blood cell (RBC) units accumulate morphologic and metabolic lesions during storage before transfusion. Pyruvate-inosine-phosphate-adenine (PIPA) solutions (Rejuvesol, Biomet, Warsaw, IN) can be incubated with RBC units to mitigate storage l ... Full text Link to item Cite

Management of Blood Product Market Withdrawals - A Single Institution's Process and Experience.

Journal Article Ann Clin Lab Sci · July 2020 OBJECTIVE: While lookback investigations follow specific Food and Drug Administration (FDA) requirements, the management of blood product market withdrawals from suppliers varies widely. Follow-up data are limited, prompting this analysis of the types and ... Link to item Cite

Effects of repleting organic phosphates in banked erythrocytes on plasma metabolites and vasoactive mediators after red cell exchange transfusion in sickle cell disease.

Journal Article Blood Transfus · May 2020 BACKGROUND: Red blood cell (RBC) exchange (RCE) transfusion therapy is indicated for certain patients with sickle cell disease (SCD). Although beneficial, this therapy is costly and inconvenient to patients, who may require it monthly or more often. Identi ... Full text Link to item Cite

Effects of a Goal Directed Transfusion Protocol on Severe Primary Graft Dysfunction after Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Transfusion during lung transplantation (LT) is linked to primary graft dysfunction (PGD) and worsened outcomes. Goal-directed protocols have improved outcomes in cardiac surgical populations and decreased transfusions in LT on cardiopulmonary byp ... Full text Cite

Perioperative Characteristics Associated with Transfusion-Free Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Blood transfusion during lung transplantation (LT) surgery is common. There is little evidence to identify potential candidates for transfusion-free LT surgery. We describe patient and procedural characteristics of LT patients in the era of ECMO a ... Full text Cite

Acute pulmonary injury in hematology patients supported with pathogen-reduced and conventional platelet components.

Journal Article Blood Adv · May 14, 2024 Patients treated with antineoplastic therapy often develop thrombocytopenia requiring platelet transfusion, which has potential to exacerbate pulmonary injury. This study tested the hypothesis that amotosalen-UVA pathogen-reduced platelet components (PRPCs ... Full text Link to item Cite

Increased red blood cell alloimmunization rates in transfused aplastic anemia and myelofibrosis patients.

Journal Article Transfusion · October 2023 BACKGROUND: Red blood cell (RBC) alloimmunization (AI) is a well-known complication of RBC transfusions, which results in the formation of alloantibodies to non-self antigens on donor RBCs, putting patients at risk of transfusion-related complications. The ... Full text Link to item Cite

Development of New Donor-Specific and Human Leukocyte Antigen Antibodies After Transfusion in Adult Lung Transplantation.

Journal Article J Cardiothorac Vasc Anesth · September 2023 OBJECTIVES: The development of new human leukocyte antigens (HLAs) and donor-specific antibodies (DSAs) in patients are associated with worse outcomes following lung transplantation. The authors aimed to examine the relationship between blood product trans ... Full text Open Access Link to item Cite

Transfusion of ABO-group identical red blood cells following uncrossmatched transfusion does not lead to higher mortality in civilian trauma patients.

Journal Article Transfusion · May 2023 BACKGROUND: Questions persist about the safety of switching non-group O recipients of group O uncrossmatched red blood cells (RBC) or low titer group O whole blood (LTOWB) to ABO-identical RBCs during their resuscitation. METHODS: The database of an earlie ... Full text Link to item Cite

Massive Transfusion Protocol Adherence: Relationship to Trauma Patient Outcomes.

Journal Article J Trauma Nurs · May 2023 BACKGROUND: Ongoing evaluation of massive transfusion protocol adherence is critical to ensure better trauma patient outcomes. OBJECTIVE: This quality improvement initiative aimed to determine provider adherence to a recently revised massive transfusion pr ... Full text Link to item Cite

The importance of patient blood management for patients, providers and the public

Journal Article Annals of Blood · January 1, 2023 Patient blood management (PBM) is a systematic and multidisciplinary approach to provide higher-quality care to patients who have traditionally received blood transfusions as a part of their therapy. It is an alternative approach to the conventional transf ... Full text Cite

Hospital red blood cell and platelet supply and utilization from March to December of the first year of the COVID-19 pandemic: The BEST collaborative study.

Journal Article Transfusion · August 2022 BACKGROUND: At the start of the coronavirus disease 2019 (COVID-19) pandemic, widespread blood shortages were anticipated. We sought to determine how hospital blood supply and blood utilization were affected by the first wave of COVID-19. STUDY DESIGN AND ... Full text Link to item Cite

Comparative risk of pulmonary adverse events with transfusion of pathogen reduced and conventional platelet components.

Journal Article Transfusion · July 2022 BACKGROUND: Platelet transfusion carries risk of transfusion-transmitted infection (TTI). Pathogen reduction of platelet components (PRPC) is designed to reduce TTI. Pulmonary adverse events (AEs), including transfusion-related acute lung injury and acute ... Full text Link to item Cite

Blood product transfusion and lung transplant outcomes: A systematic review.

Journal Article Clin Transplant · October 2021 The perioperative transfusion of blood products has long been linked to development of acute lung injury and associated with mortality across both medical and surgical patient populations.1,2 The need for blood product transfusion during and after lung tra ... Full text Link to item Cite

The Association of Increased FFP:RBC Transfusion Ratio to Primary Graft Dysfunction in Bleeding Lung Transplantation Patients.

Journal Article J Cardiothorac Vasc Anesth · November 2020 OBJECTIVES: Lung transplantation is associated with a significant risk of needed transfusion. Although algorithm-based transfusion strategies that promote a high fresh frozen plasma:red blood cells (FFP:RBC) ratio have reduced overall blood product require ... Full text Link to item Cite

Transfusion of blood components containing ABO-incompatible plasma does not lead to higher mortality in civilian trauma patients.

Journal Article Transfusion · November 2020 BACKGROUND: This study investigated the effect on mortality of transfusing ABO-incompatible plasma from all sources during trauma resuscitation. METHODS: Demographic, transfusion, and survival data were retrospectively extracted on civilian trauma patients ... Full text Link to item Cite

The effect of pathogen inactivation on cryoprecipitate: a functional and quantitative evaluation.

Journal Article Blood transfusion = Trasfusione del sangue · November 2020 BackgroundAs a pooled donor blood product, cryoprecipitate (cryo) carries risks of pathogen transmission. Pathogen inactivation (PI) improves the safety of cryoprecipitate, but its effects on haemostatic properties remain unclear. This study inves ... Full text Cite

Comparison of the platelet activation status of single-donor platelets obtained with two different cell separator technologies.

Journal Article Transfusion · September 2020 BACKGROUND: The microparticle content (MP%) of apheresis platelets-a marker of platelet activation-is influenced by donor factors and by external stressors during collection and storage. This study assessed the impact of apheresis technology and other fact ... Full text Link to item Cite

Anticoagulation Strategies in the Perioperative Period for Lung Transplant.

Journal Article Ann Thorac Surg · July 2020 Patients who are undergoing lung transplantation may require systemic anticoagulation in the perioperative period for various indications at the time of the procedure. Four-factor prothrombin complex concentrate has been approved in the United States to re ... Full text Link to item Cite

Rejuvenation solution as an adjunct cold storage solution maintains physiological haemoglobin oxygen affinity during early-storage period of red blood cells.

Journal Article Vox Sang · July 2020 BACKGROUND: Red blood cell (RBC) units accumulate morphologic and metabolic lesions during storage before transfusion. Pyruvate-inosine-phosphate-adenine (PIPA) solutions (Rejuvesol, Biomet, Warsaw, IN) can be incubated with RBC units to mitigate storage l ... Full text Link to item Cite

Management of Blood Product Market Withdrawals - A Single Institution's Process and Experience.

Journal Article Ann Clin Lab Sci · July 2020 OBJECTIVE: While lookback investigations follow specific Food and Drug Administration (FDA) requirements, the management of blood product market withdrawals from suppliers varies widely. Follow-up data are limited, prompting this analysis of the types and ... Link to item Cite

Effects of repleting organic phosphates in banked erythrocytes on plasma metabolites and vasoactive mediators after red cell exchange transfusion in sickle cell disease.

Journal Article Blood Transfus · May 2020 BACKGROUND: Red blood cell (RBC) exchange (RCE) transfusion therapy is indicated for certain patients with sickle cell disease (SCD). Although beneficial, this therapy is costly and inconvenient to patients, who may require it monthly or more often. Identi ... Full text Link to item Cite

Effects of a Goal Directed Transfusion Protocol on Severe Primary Graft Dysfunction after Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Transfusion during lung transplantation (LT) is linked to primary graft dysfunction (PGD) and worsened outcomes. Goal-directed protocols have improved outcomes in cardiac surgical populations and decreased transfusions in LT on cardiopulmonary byp ... Full text Cite

Perioperative Characteristics Associated with Transfusion-Free Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Blood transfusion during lung transplantation (LT) surgery is common. There is little evidence to identify potential candidates for transfusion-free LT surgery. We describe patient and procedural characteristics of LT patients in the era of ECMO a ... Full text Cite

Interval decline in hemoglobin A is associated with annual clinical event rate in sickle cell anemia patients receiving maintenance apheresis RBC exchange.

Journal Article Transfusion · August 2019 BACKGROUND: Apheresis red blood cell (RBC) exchange (RCE) is a standard intervention for patients with sickle cell anemia (SCA) who have had previous thromboembolic stroke or intractable chronic pain. Replacing sickling cells with those containing hemoglob ... Full text Link to item Cite

Massive transfusion in the pediatric population: A systematic review and summary of best-evidence practice strategies.

Journal Article J Trauma Acute Care Surg · April 2019 BACKGROUND: Pediatric patients require massive transfusion (MT) in a variety of settings. Multiple studies of adult MT support balanced ratio transfusion to improve outcomes; however, it is unclear if these findings can be extrapolated to pediatric populat ... Full text Link to item Cite

RhD compatibility

Chapter · May 29, 2018 Full text Cite

Estimation of Achievable Oxygen Consumption Following Transfusion With Rejuvenated Red Blood Cells.

Journal Article Semin Thorac Cardiovasc Surg · 2018 Erythrocyte storage induces a nonphysiological increase in hemoglobin-oxygen affinity (quantified by low p50, the oxygen tension at 50% hemoglobin saturation), which can be restored through biochemical rejuvenation. The objective was to mathematically mode ... Full text Link to item Cite

Communications: To contributors to the 2017 issues

Journal Article Immunohematology · January 1, 2017 Cite

Anti-Jka that are detected by solid-phase red blood cell adherence but missed by gel testing can cause hemolytic transfusion reactions.

Journal Article Transfusion · December 2016 BACKGROUND: Kidd blood group antibodies are notorious for transient detection and hemolytic transfusion reactions. This report compares the rate of detection of anti-Jka when using gel column agglutination versus solid-phase red blood cell adherence (SPRCA ... Full text Link to item Cite

Non-specific red cell reactivity in an obstetric population.

Journal Article J Matern Fetal Neonatal Med · September 2016 OBJECTIVE: To examine non-specific red cell reactivity (NSR) on antibody (Ab) screening of obstetric inpatients. METHODS: Observational study of 5438 obstetric inpatients (2009-2013). Ab-positive patients were identified and their records reviewed for NSR, ... Full text Link to item Cite

Inventory management strategies that reduce the age of red blood cell components at the time of transfusion.

Journal Article Transfusion · July 2016 BACKGROUND: There has been interest concerning patient outcomes when older red blood cell (RBC) components are utilized. Inventory management is key to maintaining a stock of fresher RBCs for general transfusion needs. We have altered our practice for RBC ... Full text Link to item Cite

Perioperative Removal of Autologous Platelets.

Journal Article Ann Thorac Surg · November 2015 Full text Link to item Cite

The treatment of nephrogenic systemic fibrosis with therapeutic plasma exchange.

Journal Article J Clin Apher · August 2013 BACKGROUND: Nephrogenic systemic fibrosis (NSF), also known as nephrogenic sclerosing dermopathy (NSD), is a rare progressive fibrosing disease associated with gadolinium based dyes in patients with renal disease. The exact pathophysiology is not well unde ... Full text Link to item Cite

Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A.

Journal Article Virology · November 10, 2012 KSHV inflammatory cytokine syndrome (KICS) is a newly described condition characterized by systemic illness as a result of systemic, lytic KSHV infection. We used Illumina sequencing to establish the DNA vironome of blood from such a patient. It identified ... Full text Link to item Cite

In reply

Journal Article Transfusion · July 1, 2012 Full text Cite

Seasonal association of thrombotic thrombocytopenic purpura.

Journal Article Transfusion · July 2012 BACKGROUND: Thrombotic thrombocytopenic purpura (TTP), a thrombotic microangiopathy, is a clinical diagnosis, characterized by microangiopathic hemolytic anemia and thrombocytopenia without another likely explanation. Some initiators of the disease are wel ... Full text Link to item Cite

Performance evaluation of the Helena V8 capillary electrophoresis system.

Journal Article Clin Biochem · June 2012 OBJECTIVES: To compare the performance characteristics of the Helena V8® and Sebia CAPILLARYS2® automated capillary electrophoresis systems to agarose gel serum protein electrophoresis (SPE) and immunofixation electrophoresis (IFE) using the Helena SPIFE30 ... Full text Link to item Cite

Rapid increase in parasitemia following red cell exchange for malaria

Journal Article Journal of Clinical Apheresis · December 1, 2011 Full text Cite

Rapid increases in parasitemia following red cell exchange for malaria.

Journal Article J Clin Apher · December 2011 Exchange transfusion is frequently used as an adjunctive treatment of severe malaria, although the efficacy of exchange transfusion as therapy for severe malaria remains controversial. The major perceived benefit of exchange transfusion is the rapid reduct ... Full text Link to item Cite

Images in clinical medicine. Digital gangrene.

Journal Article N Engl J Med · April 21, 2011 Full text Link to item Cite

Proximal-type epithelioid sarcoma

Journal Article Laboratory Medicine · August 1, 2010 Proximal-type epithelioid sarcoma (PES) is a rare variant of epithelioid sarcoma (ES) presenting in either a proximal extremity or axial location. Compared to the classic type of ES, the proximal variant demonstrates more aggressive behavior. The classic a ... Full text Cite

Is it quinine TTP/HUS or quinine TMA? ADAMTS13 levels and implications for therapy.

Journal Article J Clin Apher · 2009 Thrombocytopenia with or without microangiopathy following quinine is often referred to as quinine "hypersensitivity." When schistocytes are present it is frequently termed "quinine-associated TTP/HUS." A severe deficiency of the vWF-cleaving protease, ADA ... Full text Link to item Cite