Jessica Dale Tenenbaum | Scholars@Duke

Jessica Dale Tenenbaum
Assistant Professor of Biostatistics & Bioinformatics

Dr. Tenenbaum is a faculty member in Duke's Department of Biostatistics and Bioinformatics, Division of Translational Informatics. Her primary research interests are 1. Infrastructure and standards to enable research collaboration and integrative data analysis; 2. Informatics to enable precision medicine; 3. Mental health informatics, and 4. Ethical, legal, and social issues that arise in translational research, direct to consumer genetic testing, and data sharing. At Duke, Dr. Tenenbaum has overseen the development of the MURDOCK Integrated Data Repository (MIDR) for the management of clinical, omic, biobanking, and consent data as well as experimental and protocol metadata in the context of the MURDOCK Study. (www.murdock-study.com) She is also the informatics faculty lead for the Alzheimer's Disease Metabolomics Consortium. Nationally, Dr. Tenenbaum plays a leadership role in the American Medical Informatics Association, serving as Chair of the Genomics and Translational Bioinformatics Working Group and as an elected member of the Board of Directors. She is an Associate Editor for the Journal of Biomedical Informatics and serves on the advisory panel for Nature Publishing Group's Scientific Data initiative. After earning her bachelor’s degree in biology from Harvard, Dr. Tenenbaum worked as a program manager at Microsoft Corporation in Redmond, WA for six years before pursuing a PhD in biomedical informatics at Stanford University.

Current Appointments & Affiliations

Assistant Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2015
Associate Director for Bioinformatics in the Duke Translational Medicine Institute, Biostatistics & Bioinformatics, Basic Science Departments 2015
Affiliate of the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2014

Contact Information

2424ERWIN Road Ste 1105, 11039 Hock Plaza, Durham, NC 27705
Duke Box 2721, Durham, NC 27710
jessie.tenenbaum@duke.edu (919) 684-7308

Background
Education, Training, & Certifications
- Ph.D., Stanford University School of Medicine 2007
Expertise
Subject Headings
Research
Selected Grants
- Improved Disease Stratification Using Electronic Health Records awarded by National Institutes of Health 2017 - 2020
- Metabolic Signatures Underlying Vascular Risk Factors for Alzheimer-type Dementias awarded by National Institutes of Health 2015 - 2020
- A hands-on, integrative next-generation sequencing course: design, experiment, and analysis awarded by National Institutes of Health 2016 - 2019
- AMP AD Project B Biomarker Pilot Study: An integrated biomarker discovery pilot study (Broad/Rush-Emory-Duke) awarded by Foundation for the National Institutes of Health 2016 - 2018
- Metabolic Networks and Pathways in Alzheimer's Disease awarded by National Institutes of Health 2014 - 2018
- Duke CTSA (UL1) awarded by National Institutes of Health 2013 - 2018
- NIH BD2K Standards Coordination Center (SCC) - NIH-BD2K-03 awarded by Enterprise Science and Computing, Inc. 2015 - 2016
- Measuring and Talking to Patients about the Accuracy of Data used in Patient Outcomes Research awarded by Patient-Centered Outcomes Research Institute 2015 - 2016
- CTSA UL awarded by National Institutes of Health 2006 - 2012
- Duke Clinical and Translational Science Institute awarded by National Institutes of Health 2006 - 2011
Publications & Artistic Works
Selected Publications
- Book Sections
  - Tenenbaum, JD. "Personalized medicine." In Translational Informatics: Realizing the Promise of Knowledge-Driven Healthcare, 35-60. January 1, 2015. Full Text
- Conference Papers
  - Payne, PRO, Huang, K, Shah, NH, and Tenenbaum, J. "OPEN DATA FOR DISCOVERY SCIENCE." January 2016.
  - Tenenbaum, JD, Madhavan, S, Freimuth, RR, Denny, JC, and Frey, L. "Translational bioinformatics 101." January 1, 2016.
- Journal Articles
  - Toledo, JB, Arnold, M, Kastenmüller, G, Chang, R, Baillie, RA, Han, X, Thambisetty, M, Tenenbaum, JD, Suhre, K, Thompson, JW, John-Williams, LS, MahmoudianDehkordi, S, Rotroff, DM, Jack, JR, Motsinger-Reif, A, Risacher, SL, Blach, C, Lucas, JE, Massaro, T, Louie, G, Zhu, H, Dallmann, G, Klavins, K, Koal, T, Kim, S, Nho, K, Shen, L, Casanova, R, Varma, S, Legido-Quigley, C, Moseley, MA, Zhu, K, Henrion, MYR, van der Lee, SJ, Harms, AC, Demirkan, A, Hankemeier, T, van Duijn, CM, and Trojanowski, JQ et al. "Metabolic network failures in Alzheimer's disease: A biochemical road map." Alzheimer's & dementia : the journal of the Alzheimer's Association 13, no. 9 (September 2017): 965-984. Full Text
  - Tenenbaum, JD, and Goodman, KW. "Beyond the Genetic Information Nondiscrimination Act: ethical and economic implications of the exclusion of disability, long-term care and life insurance." Personalized Medicine 14, no. 2 (March 2017): 153-157. Full Text
  - Garza, M, Del Fiol, G, Tenenbaum, J, Walden, A, and Zozus, MN. "Evaluating common data models for use with a longitudinal community registry." Journal of biomedical informatics 64 (December 2016): 333-341. Full Text
  - Tenenbaum, JD, Avillach, P, Benham-Hutchins, M, Breitenstein, MK, Crowgey, EL, Hoffman, MA, Jiang, X, Madhavan, S, Mattison, JE, Nagarajan, R, Ray, B, Shin, D, Visweswaran, S, Zhao, Z, and Freimuth, RR. "An informatics research agenda to support precision medicine: seven key areas." Journal of the American Medical Informatics Association : JAMIA 23, no. 4 (July 2016): 791-795. Full Text
  - "More on Data Sharing." New England Journal of Medicine 374, no. 19 (May 12, 2016): 1895-1897. Full Text
  - Embi, PJ, and Tenenbaum, JD. "More on Data Sharing." The New England journal of medicine 374, no. 19 (May 2016): 1896-. (Letter) Full Text
  - Hall, JL, Ryan, JJ, Bray, BE, Brown, C, Lanfear, D, Newby, LK, Relling, MV, Risch, NJ, Roden, DM, Shaw, SY, Tcheng, JE, Tenenbaum, J, Wang, TN, Weintraub, WS, American Heart Association Professional and Public Education and Publications Committee of the Council on Functional Genomics and Translational Biology, , Council on Clinical Cardiology, , Council on Epidemiology and Prevention, , Council on Quality of Care and Outcomes Research, and and Stroke Council, . "Merging Electronic Health Record Data and Genomics for Cardiovascular Research: A Science Advisory From the American Heart Association." Circulation. Cardiovascular genetics 9, no. 2 (April 2016): 193-202. Full Text
  - Tenenbaum, JD. "Translational Bioinformatics: Past, Present, and Future." Genomics, proteomics & bioinformatics 14, no. 1 (February 11, 2016): 31-41. (Review) Full Text
  - Zozus, MN, Richesson, RL, Walden, A, Tenenbaum, JD, and Hammond, WE. "Research Reproducibility in Longitudinal Multi-Center Studies Using Data from Electronic Health Records." AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science 2016 (January 2016): 279-285.
  - Tenenbaum, JD, Sansone, S-A, and Haendel, M. "A sea of standards for omics data: sink or swim?." Journal of the American Medical Informatics Association 21, no. 2 (March 2014): 200-203. Full Text
  - Bernstam, EV, Tenenbaum, JD, and Kuperman, GJ. "Preserving an integrated view of informatics." Journal of the American Medical Informatics Association 21, no. e1 (February 2014): e178-e179. (Letter) Full Text
  - Blach, C, Del Fiol, G, Dundee, C, Frund, J, Richesson, R, Smerek, M, Walden, A, and Tenenbaum, JD. "Use of RxNorm and NDF-RT to normalize and characterize participant-reported medications in an i2b2-based research repository." AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science 2014 (January 2014): 35-40.
  - Tenenbaum, J, James, A, and Paulyson-Nuñez, K. "An Altered Treatment Plan Based on Direct to Consumer (DTC) Genetic Testing: Personalized Medicine from the Patient/Pin-cushion Perspective." Journal of Personalized Medicine 2, no. 4 (December 2012): 192-200. Full Text
  - MacKenzie, SL, Wyatt, MC, Schuff, R, Tenenbaum, JD, and Anderson, N. "Practices and perspectives on building integrated data repositories: results from a 2010 CTSA survey." Journal of the American Medical Informatics Association 19, no. e1 (June 2012): e119-e124. Full Text
  - Shah, NH, and Tenenbaum, JD. "The coming age of data-driven medicine: translational bioinformatics' next frontier." Journal of the American Medical Informatics Association 19, no. e1 (June 2012): e2-e4. Full Text
  - Bhattacharya, S, Dunham, AA, Cornish, MA, Christian, VA, Ginsburg, GS, Tenenbaum, JD, Nahm, ML, Miranda, ML, Califf, RM, Dolor, RJ, and Newby, LK. "The Measurement to Understand Reclassification of Disease of Cabarrus/Kannapolis (MURDOCK) Study Community Registry and Biorepository." Am J Transl Res 4, no. 4 (2012): 458-470. Link to Item
  - Tenenbaum, JD, Christian, V, Cornish, MA, Dolor, RJ, Dunham, AA, Ginsburg, GS, Kraus, VB, McHutchison, JG, Nahm, ML, Newby, LK, Svetkey, LP, Udayakumar, K, and Califf, RM. "The MURDOCK Study: a long-term initiative for disease reclassification through advanced biomarker discovery and integration with electronic health records." Am J Transl Res 4, no. 3 (2012): 291-301. Link to Item
  - Tenenbaum, JD, Whetzel, PL, Anderson, K, Borromeo, CD, Dinov, ID, Gabriel, D, Kirschner, B, Mirel, B, Morris, T, Noy, N, Nyulas, C, Rubenson, D, Saxman, PR, Singh, H, Whelan, N, Wright, Z, Athey, BD, Becich, MJ, Ginsburg, GS, Musen, MA, Smith, KA, Tarantal, AF, Rubin, DL, and Lyster, P. "The Biomedical Resource Ontology (BRO) to enable resource discovery in clinical and translational research." J Biomed Inform 44, no. 1 (February 2011): 137-145. Full Text Link to Item
  - Tenenbaum, JD, Walker, MG, Utz, PJ, and Butte, AJ. "Expression-based Pathway Signature Analysis (EPSA): mining publicly available microarray data for insight into human disease." BMC medical genomics 1 (October 20, 2008): 51-. Full Text
  - Balboni, I, Limb, C, Tenenbaum, JD, and Utz, PJ. "Evaluation of microarray surfaces and arraying parameters for autoantibody profiling." Proteomics 8, no. 17 (September 2008): 3443-3449. Full Text
  - Balboni, I, Chan, SM, Kattah, M, Tenenbaum, JD, Butte, AJ, and Utz, PJ. "Multiplexed protein array platforms for analysis of autoimmune diseases." Annual review of immunology 24 (January 2006): 391-418. (Review) Full Text
  - Lee, TJ, Pouliot, Y, Wagner, V, Gupta, P, Stringer-Calvert, DWJ, Tenenbaum, JD, and Karp, PD. "BioWarehouse: a bioinformatics database warehouse toolkit." BMC bioinformatics 7 (January 2006): 170-. Full Text

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Education, Training, & Certifications

Subject Headings

Selected Grants

Selected Publications

Book Sections

Conference Papers

Journal Articles