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Jia Wen

Assistant Research Professor in Molecular Genetics and Microbiology
Molecular Genetics and Microbiology

Research Interests


Intestinal absorption of energy-rich dietary lipids is a key initial step within the complex physiologic network that determines energy balance in all animals. This process involves coordination between intestinal epithelial cells and environmental factors such as the microbiota, but the underlying mechanisms remain unresolved. My overarching goal is to understand the genetic and environmental factors that modulate intestinal physiology. To this end, I have used bacterial, animal, and organoid models to explore key host and microbial mechanisms that regulate intestinal lipid absorption. These experiences have allowed me to establish expertise in microbiology, physiology, genetics, and genomics, and prepared me to be an independent scientist.

Selected Grants


Identifying genes required for digestive physiology and lipid metabolism

ResearchPostdoctoral Associate · Awarded by Johns Hopkins University · 2013 - 2028

Microbial regulation of intestinal lipid metabolism and its physiological consequences

ResearchInvestigator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2021 - 2026

Deciphering host-microbiota regulation of apical and basolateral absorption of lipid in enterocytes

ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2024 - 2024

Immune Compromised Zebrafish for Cell Transplantation

ResearchPostdoctoral Associate · Awarded by Massachusetts General Hospital · 2013 - 2022

Microbial regulation of host nutrient metabolism

ResearchPostdoctoral Associate · Awarded by National Institutes of Health · 2013 - 2020