Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Delaware 2005
• 

  Previous Appointments & Affiliations

  • Assistant Professor in Medicine, Medicine, Gastroenterology, Medicine 2017 - 2020
• Expertise
• 

  Subject Headings

  • Brain--Cancer
  • Breast--Cancer--Research
• 

  Global Scholarship

  • Research

    • United States of America (Country) 
• Research
• 

  Selected Grants

  • Treatment of radiation proctitis in prostate cancer patients with a novel inducer of autophagy awarded by Department of Defense 2020 - 2023
  • Inhibition of Wnt/B-Catenin Signaling in Colorectal Cancer Therapy awarded by National Institutes of Health 2013 - 2019
  • Targeting the WNT/beta-catenin pathway in triple negative breast cancer awarded by Department of Defense 2013 - 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Wang, Jiangbo, Xiu-Rong Ren, Hailan Piao, Shengli Zhao, Takuya Osada, Richard T. Premont, Robert A. Mook, Michael A. Morse, Herbert Kim Lyerly, and Wei Chen. “Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy.” Biochem J 476, no. 3 (February 8, 2019): 535–46. https://doi.org/10.1042/BCJ20180385.
       Full Text  Link to Item
    • Wang, Jiangbo, Robert A. Mook, Xiu-Rong Ren, Qingfu Zhang, Genevieve Jing, Min Lu, Ivan Spasojevic, H Kim Lyerly, David Hsu, and Wei Chen. “Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth.” Bioorg Med Chem 26, no. 20 (November 1, 2018): 5435–42. https://doi.org/10.1016/j.bmc.2018.09.016.
       Full Text  Link to Item
    • Chen, Wei, Robert A. Mook, Richard T. Premont, and Jiangbo Wang. “Niclosamide: Beyond an antihelminthic drug.” Cell Signal 41 (January 2018): 89–96. https://doi.org/10.1016/j.cellsig.2017.04.001.
       Full Text  Link to Item
    • Mook, Robert A., Xiu-Rong Ren, Jiangbo Wang, Hailan Piao, Larry S. Barak, H. Kim Lyerly, and Wei Chen. “Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis.” Bioorg Med Chem 25, no. 6 (March 15, 2017): 1804–16. https://doi.org/10.1016/j.bmc.2017.01.046.
       Full Text  Link to Item
    • Ren, X. R., J. Wang, T. Osada, R. A. Mook, M. A. Morse, L. S. Barak, H. K. Lyerly, and W. Chen. “Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.” Breast Cancer Res 17, no. 1 (December 2015): 528. https://doi.org/10.1186/s13058-015-0528-9.
       Full Text  Link to Item
    • Mook, Robert A., Jiangbo Wang, Xiu-Rong Ren, Minyong Chen, Ivan Spasojevic, Larry S. Barak, H Kim Lyerly, and Wei Chen. “Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.” Bioorg Med Chem 23, no. 17 (September 1, 2015): 5829–38. https://doi.org/10.1016/j.bmc.2015.07.001.
       Full Text  Link to Item
    • Barak, Larry S., Yushi Bai, Joshua C. Snyder, Jiangbo Wang, Wei Chen, and Marc G. Caron. “Triphenylmethane dye activation of beta-arrestin.” Biochemistry 52, no. 32 (August 13, 2013): 5403–14. https://doi.org/10.1021/bi400217r.
       Full Text  Link to Item
    • Lu, Jiuyi, Minyong Chen, Xiu-Rong Ren, Jiangbo Wang, H Kim Lyerly, Larry Barak, and Wei Chen. “Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1.” Plos One 8, no. 5 (2013): e63353. https://doi.org/10.1371/journal.pone.0063353.
       Full Text  Link to Item
    • Wang, Jiangbo, Robert A. Mook, Jiuyi Lu, David M. Gooden, Anthony Ribeiro, Anchen Guo, Larry S. Barak, H Kim Lyerly, and Wei Chen. “Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.” Bioorg Med Chem 20, no. 22 (November 15, 2012): 6751–57. https://doi.org/10.1016/j.bmc.2012.09.030.
       Full Text  Link to Item
    • Wang, Jiangbo, Jiuyi Lu, Robert A. Mook, Min Zhang, Shengli Zhao, Larry S. Barak, Jonathan H. Freedman, H Kim Lyerly, and Wei Chen. “The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks.” Toxicol Sci 128, no. 2 (August 2012): 517–23. https://doi.org/10.1093/toxsci/kfs165.
       Full Text  Link to Item
    • Ren, Xiu-Rong, Junping Wei, Gangjun Lei, Jiangbo Wang, Jiuyi Lu, Wenle Xia, Neil Spector, et al. “Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.” Breast Cancer Res 14, no. 3 (June 7, 2012): R89. https://doi.org/10.1186/bcr3204.
       Full Text  Link to Item
    • Wang, Jiangbo, Larry S. Barak, Robert A. Mook, and Wei Chen. “Glucocorticoid hedgehog agonists in neurogenesis.” Vitam Horm 87 (2011): 207–15. https://doi.org/10.1016/B978-0-12-386015-6.00030-5.
       Full Text  Link to Item
    • Choi, Steve S., Rafal P. Witek, Liu Yang, Alessia Omenetti, Wing-Kin Syn, Cynthia A. Moylan, Youngmi Jung, et al. “Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells.” Hepatology 52, no. 1 (July 2010): 278–90. https://doi.org/10.1002/hep.23649.
       Full Text  Link to Item
    • Wang, Jiangbo, Jiuyi Lu, Michael C. Bond, Minyong Chen, Xiu-Rong Ren, H Kim Lyerly, Larry S. Barak, and Wei Chen. “Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine.” Proc Natl Acad Sci U S A 107, no. 20 (May 18, 2010): 9323–28. https://doi.org/10.1073/pnas.0910712107.
       Full Text  Open Access Copy  Link to Item
    • Ochoa, Begoña, Wing-Kin Syn, Igotz Delgado, Gamze F. Karaca, Youngmi Jung, Jiangbo Wang, Ana M. Zubiaga, et al. “Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice.” Hepatology 51, no. 5 (May 2010): 1712–23. https://doi.org/10.1002/hep.23525.
       Full Text  Link to Item
    • Chen, Minyong, Melanie Philipp, Jiangbo Wang, Richard T. Premont, Tiffany R. Garrison, Marc G. Caron, Robert J. Lefkowitz, and Wei Chen. “G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.” J Biol Chem 284, no. 50 (December 11, 2009): 35040–48. https://doi.org/10.1074/jbc.M109.047456.
       Full Text  Link to Item
    • Chen, Minyong, Jiangbo Wang, Jiuyi Lu, Michael C. Bond, Xiu-Rong Ren, H Kim Lyerly, Larry S. Barak, and Wei Chen. “The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.” Biochemistry 48, no. 43 (November 3, 2009): 10267–74. https://doi.org/10.1021/bi9009677.
       Full Text  Link to Item
    • Syn, Wing-Kin, Youngmi Jung, Alessia Omenetti, Manal Abdelmalek, Cynthia D. Guy, Liu Yang, Jiangbo Wang, et al. “Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.” Gastroenterology 137, no. 4 (October 2009): 1478-1488.e8. https://doi.org/10.1053/j.gastro.2009.06.051.
       Full Text  Link to Item
    • Kovacs, Jeffrey J., Erin J. Whalen, Renshui Liu, Kunhong Xiao, Jihee Kim, Minyong Chen, Jiangbo Wang, Wei Chen, and Robert J. Lefkowitz. “Beta-arrestin-mediated localization of smoothened to the primary cilium.” Science 320, no. 5884 (June 27, 2008): 1777–81. https://doi.org/10.1126/science.1157983.
       Full Text  Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.