Current Appointments & Affiliations
Assistant Professor in Medicine
·
2021 - Present
Medicine, Gastroenterology,
Medicine
Recent Publications
Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy.
Journal Article Biochem J · February 8, 2019 The Wnt signaling pathway, known for regulating genes critical to normal embryonic development and tissue homeostasis, is dysregulated in many types of cancer. Previously, we identified that the anthelmintic drug niclosamide inhibited Wnt signaling by prom ... Full text Link to item CiteIdentification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth.
Journal Article Bioorg Med Chem · November 1, 2018 The Wnt signaling pathway is critical for normal tissue development and is an underlying mechanism of disease when dysregulated. Previously, we reported that the drug Niclosamide inhibits Wnt/β-catenin signaling by decreasing the cytosolic levels of Dishev ... Full text Link to item CiteNiclosamide: Beyond an antihelminthic drug.
Journal Article Cell Signal · January 2018 Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of people worldwide. However recent studies have indicated that niclosamide may have broad clinical applications for the treatment of diseases other than those caused ... Full text Link to item CiteRecent Grants
Sex differences in delayed development of gastrointestinal fibrosis after acute radiation exposure
ResearchResearch Scientist · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2027Adipose tissue-colorectal tumor cross-talk: new targets for breaking the obesity-cancer link
ResearchLab. Res. Anal. · Awarded by University of Utah · 2021 - 2026Role of immune regulation in colorectal cancer chemotherapeutic response
ResearchLab Research Analyst I · Awarded by Yale University · 2021 - 2025View All Grants
Education, Training & Certifications
University of Delaware ·
2005
Ph.D.