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Jin Soo Yoo

Assistant Professor of Surgery
Surgery, Minimally Invasive Surgery
?, Durham, NC 27710
Metabolic and Weight Loss Surgery, 407 Crutchfield St, Durham, NC 27713

Selected Publications


T-line Hernia Mesh Repairs of Large Umbilical Hernias: Technique and Short-term Outcomes.

Journal Article Plast Reconstr Surg Glob Open · March 2024 BACKGROUND: The T-line hernia mesh is a synthetic, polypropylene mesh specifically designed to prevent anchor point failure by evenly distributing tension through mesh suture extensions. This case series illustrates the first clinical application of the T- ... Full text Link to item Cite

Development of a prospective biliary dashboard to compare performance and surgical cost.

Journal Article Surg Endosc · November 2023 BACKGROUND: Transparency around surgeon level data may align healthcare delivery with quality care for patients. Biliary surgery includes numerous procedures performed by both general surgeons and subspecialists alike. Cholecystectomy is a common surgical ... Full text Link to item Cite

Evolving concepts in ventral hernia repair and physical therapy: prehabilitation, rehabilitation, and analogies to tendon reconstruction.

Journal Article Hernia · August 2021 PURPOSE: The abdominal wall and musculoskeletal tendons share many anatomic, physiologic, and functional characteristics. This review aims to highlight these similar characteristics and to present a rationale why the treatment principles of successful musc ... Full text Link to item Cite

Development and Evaluation of a Novel Instrument to Measure Severity of Intraoperative Events Using Video Data.

Journal Article Ann Surg · August 2020 OBJECTIVE: To develop and evaluate a novel instrument to measure SEVERE processes using video data. BACKGROUND: Surgical video data can serve an important role in understanding the relationship between intraoperative events and postoperative outcomes. Howe ... Full text Link to item Cite

First human use of hybrid synthetic/biologic mesh in ventral hernia repair: a multicenter trial.

Journal Article Surg Endosc · March 2018 BACKGROUND: Mesh options for reinforcement of ventral/incisional hernia (VIH) repair include synthetic or biologic materials. While each material has known advantages and disadvantages, little is understood about outcomes when these materials are used in c ... Full text Link to item Cite

Erratum to: First human use of hybrid synthetic/biologic mesh in ventral hernia repair: a multicenter trial.

Journal Article Surg Endosc · March 2018 Some values in the pages 1, 3, and 5 of the original article are corrected and also an updated Table 5 is displayed. ... Full text Link to item Cite

The Use of Fluorescence Angiography During Laparoscopic Sleeve Gastrectomy.

Journal Article JSLS · 2018 BACKGROUND AND OBJECTIVES: A new technology involving indocyanine green (ICG) fluorescence angiography has been introduced to assess tissue perfusion and perform vascular mapping during laparoscopic surgery. The purpose of this study was to describe the us ... Full text Link to item Cite

Safety and Efficacy of Polymeric Clips for Appendiceal Stump Closure.

Journal Article JSLS · 2016 BACKGROUND AND OBJECTIVES: Laparoscopic appendectomy remains one of the most common emergency general surgical procedures in the United States. In an era of increasing focus on costs in medical care, we sought to evaluate the use of polymeric clips to secu ... Full text Link to item Cite

Management of inguinal hernia recurrences (when pain is the primary symptom)

Chapter · December 9, 2015 Recurrence after inguinal hernia repair occurs in 5 % patients, while chronic pain affects 10 % of patients. Chronic pain can be debilitating, and a multidisciplinary approach to management is often necessary. Pain associated with recurrence requires an un ... Full text Cite

Inhibition of poly(ADP-ribose) polymerase enhances the effect of chemotherapy in an animal model of regional therapy for the treatment of advanced extremity malignant melanoma.

Journal Article Ann Surg Oncol · August 2010 BACKGROUND: Poly(ADP-ribose) polymerase (PARP) is an important regulator of programmed cell death in response to alkylating agents such as temozolomide (TMZ). The goal of this study was to determine if a systemically administered PARP-inhibitor (INO-1001) ... Full text Link to item Cite

Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy.

Journal Article Mol Cancer Ther · July 2010 Melanoma responds poorly to standard chemotherapy due to its intrinsic chemoresistance. Multiple genetic and molecular defects, including an activating mutation in the BRaf kinase gene, are associated with melanoma, and the resulting alterations in signal ... Full text Link to item Cite

Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma.

Journal Article Mol Cancer Ther · April 2010 In-transit metastatic melanoma, which typically presents as multifocal lesions, provides a unique setting to evaluate the utility of gene signatures for defining optimal regional therapeutic strategies and assessing the efficacy of treatment. The goal of t ... Full text Link to item Cite

Genomic and molecular profiling predicts response to temozolomide in melanoma.

Journal Article Clin Cancer Res · January 15, 2009 PURPOSE: Despite objective response rates of only approximately 13%, temozolomide remains one of the most effective single chemotherapy agents against metastatic melanoma, second only to dacarbazine, the current standard of care for systemic treatment of m ... Full text Link to item Cite

Isolated limb infusion for in-transit malignant melanoma of the extremity: a well-tolerated but less effective alternative to hyperthermic isolated limb perfusion.

Journal Article Ann Surg Oncol · August 2008 BACKGROUND: Isolated limb infusion (ILI) is a recently described minimally invasive technique developed in Australia for delivering regional chemotherapy. This study examined the efficacy and toxicity of ILI, compared to hyperthermic isolated limb perfusio ... Full text Link to item Cite

Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma.

Journal Article J Clin Oncol · May 20, 2008 9077 Background: In an era of targeted therapeutics biopsies are increasingly used to personalize cancer treatment. The utility of a single biopsy from a melanoma patient with multifocal disease to define the characteristics of that patient's tumor is uncl ... Link to item Cite

Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents.

Journal Article Mol Cancer Ther · May 2007 Five different human melanoma xenografts were used in a xenograft model of extremity melanoma to evaluate the variability of tumor response to regionally administered melphalan or temozolomide and to determine if various components of pertinent drug resist ... Full text Link to item Cite

The role of chemoresistance in regional infusion therapy for melanoma

Conference ANNALS OF SURGICAL ONCOLOGY · February 1, 2006 Link to item Cite

T-line Hernia Mesh Repairs of Large Umbilical Hernias: Technique and Short-term Outcomes.

Journal Article Plast Reconstr Surg Glob Open · March 2024 BACKGROUND: The T-line hernia mesh is a synthetic, polypropylene mesh specifically designed to prevent anchor point failure by evenly distributing tension through mesh suture extensions. This case series illustrates the first clinical application of the T- ... Full text Link to item Cite

Development of a prospective biliary dashboard to compare performance and surgical cost.

Journal Article Surg Endosc · November 2023 BACKGROUND: Transparency around surgeon level data may align healthcare delivery with quality care for patients. Biliary surgery includes numerous procedures performed by both general surgeons and subspecialists alike. Cholecystectomy is a common surgical ... Full text Link to item Cite

Evolving concepts in ventral hernia repair and physical therapy: prehabilitation, rehabilitation, and analogies to tendon reconstruction.

Journal Article Hernia · August 2021 PURPOSE: The abdominal wall and musculoskeletal tendons share many anatomic, physiologic, and functional characteristics. This review aims to highlight these similar characteristics and to present a rationale why the treatment principles of successful musc ... Full text Link to item Cite

Development and Evaluation of a Novel Instrument to Measure Severity of Intraoperative Events Using Video Data.

Journal Article Ann Surg · August 2020 OBJECTIVE: To develop and evaluate a novel instrument to measure SEVERE processes using video data. BACKGROUND: Surgical video data can serve an important role in understanding the relationship between intraoperative events and postoperative outcomes. Howe ... Full text Link to item Cite

First human use of hybrid synthetic/biologic mesh in ventral hernia repair: a multicenter trial.

Journal Article Surg Endosc · March 2018 BACKGROUND: Mesh options for reinforcement of ventral/incisional hernia (VIH) repair include synthetic or biologic materials. While each material has known advantages and disadvantages, little is understood about outcomes when these materials are used in c ... Full text Link to item Cite

Erratum to: First human use of hybrid synthetic/biologic mesh in ventral hernia repair: a multicenter trial.

Journal Article Surg Endosc · March 2018 Some values in the pages 1, 3, and 5 of the original article are corrected and also an updated Table 5 is displayed. ... Full text Link to item Cite

The Use of Fluorescence Angiography During Laparoscopic Sleeve Gastrectomy.

Journal Article JSLS · 2018 BACKGROUND AND OBJECTIVES: A new technology involving indocyanine green (ICG) fluorescence angiography has been introduced to assess tissue perfusion and perform vascular mapping during laparoscopic surgery. The purpose of this study was to describe the us ... Full text Link to item Cite

Safety and Efficacy of Polymeric Clips for Appendiceal Stump Closure.

Journal Article JSLS · 2016 BACKGROUND AND OBJECTIVES: Laparoscopic appendectomy remains one of the most common emergency general surgical procedures in the United States. In an era of increasing focus on costs in medical care, we sought to evaluate the use of polymeric clips to secu ... Full text Link to item Cite

Management of inguinal hernia recurrences (when pain is the primary symptom)

Chapter · December 9, 2015 Recurrence after inguinal hernia repair occurs in 5 % patients, while chronic pain affects 10 % of patients. Chronic pain can be debilitating, and a multidisciplinary approach to management is often necessary. Pain associated with recurrence requires an un ... Full text Cite

Inhibition of poly(ADP-ribose) polymerase enhances the effect of chemotherapy in an animal model of regional therapy for the treatment of advanced extremity malignant melanoma.

Journal Article Ann Surg Oncol · August 2010 BACKGROUND: Poly(ADP-ribose) polymerase (PARP) is an important regulator of programmed cell death in response to alkylating agents such as temozolomide (TMZ). The goal of this study was to determine if a systemically administered PARP-inhibitor (INO-1001) ... Full text Link to item Cite

Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy.

Journal Article Mol Cancer Ther · July 2010 Melanoma responds poorly to standard chemotherapy due to its intrinsic chemoresistance. Multiple genetic and molecular defects, including an activating mutation in the BRaf kinase gene, are associated with melanoma, and the resulting alterations in signal ... Full text Link to item Cite

Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma.

Journal Article Mol Cancer Ther · April 2010 In-transit metastatic melanoma, which typically presents as multifocal lesions, provides a unique setting to evaluate the utility of gene signatures for defining optimal regional therapeutic strategies and assessing the efficacy of treatment. The goal of t ... Full text Link to item Cite

Genomic and molecular profiling predicts response to temozolomide in melanoma.

Journal Article Clin Cancer Res · January 15, 2009 PURPOSE: Despite objective response rates of only approximately 13%, temozolomide remains one of the most effective single chemotherapy agents against metastatic melanoma, second only to dacarbazine, the current standard of care for systemic treatment of m ... Full text Link to item Cite

Isolated limb infusion for in-transit malignant melanoma of the extremity: a well-tolerated but less effective alternative to hyperthermic isolated limb perfusion.

Journal Article Ann Surg Oncol · August 2008 BACKGROUND: Isolated limb infusion (ILI) is a recently described minimally invasive technique developed in Australia for delivering regional chemotherapy. This study examined the efficacy and toxicity of ILI, compared to hyperthermic isolated limb perfusio ... Full text Link to item Cite

Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma.

Journal Article J Clin Oncol · May 20, 2008 9077 Background: In an era of targeted therapeutics biopsies are increasingly used to personalize cancer treatment. The utility of a single biopsy from a melanoma patient with multifocal disease to define the characteristics of that patient's tumor is uncl ... Link to item Cite

Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents.

Journal Article Mol Cancer Ther · May 2007 Five different human melanoma xenografts were used in a xenograft model of extremity melanoma to evaluate the variability of tumor response to regionally administered melphalan or temozolomide and to determine if various components of pertinent drug resist ... Full text Link to item Cite

The role of chemoresistance in regional infusion therapy for melanoma

Conference ANNALS OF SURGICAL ONCOLOGY · February 1, 2006 Link to item Cite

Optimizing a novel regional chemotherapeutic agent against melanoma: hyperthermia-induced enhancement of temozolomide cytotoxicity.

Journal Article Clin Cancer Res · January 1, 2006 PURPOSE: Previous preclinical studies have shown that regional temozolomide therapy via isolated limb infusion is more effective than melphalan, the current drug of choice for regional chemotherapy for advanced extremity melanoma. The aim of this study was ... Full text Link to item Cite

Glutathione S-transferase as a marker of metastatic potential in malignant melanoma

Conference Journal of the American College of Surgeons · September 2005 Full text Cite