Scholars@Duke
John Michael Carney

John Michael Carney

Assistant Professor of Pathology
Pathology
john.carney@duke.edu
40 Duke Medicine Circle, DUMC Box 3712, Rm 214B, Durham, NC 27710
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Selected Publications

The diagnosis of asbestosis in the 21st century: a clinicopathological correlation of 102 cases.

Journal Article Ultrastruct Pathol · March 3, 2024 Asbestosis, defined as diffuse pulmonary fibrosis caused by inhalation of asbestos fibers, occurs after heavy exposures to asbestos dust over several decades. Because workplace exposures have been significantly curtailed since the banning of asbestos in in ... Full text Link to item Cite

The over diagnosis of diffuse mesothelioma: An analysis of 311 cases with recommendations for the avoidance of pitfalls.

Journal Article Ann Diagn Pathol · February 2024 BACKGROUND: The diagnosis of mesothelioma may be challenging. We investigated a large database of cases in order to determine the frequency with which a diagnosis of mesothelioma was made incorrectly and the most frequent causes of error. DESIGN: A databas ... Full text Link to item Cite

Chronological trends in the causation of malignant mesothelioma: Fiber burden analysis of 619 cases over four decades.

Journal Article Environ Res · August 1, 2023 Malignant mesothelioma is a relatively rare malignancy with a strong association with prior asbestos exposure. A percentage of cases is not related to asbestos, and fiber analysis of lung tissue is a useful methodology for identifying idiopathic or spontan ... Full text Link to item Cite

Comparison of Forceps, Cryoprobe, and Thoracoscopic Lung Biopsy for the Diagnosis of Interstitial Lung Disease - The CHILL Study.

Journal Article Respiration · 2022 RATIONALE: Transbronchial lung cryobiopsy (TBLC) has emerged as a less invasive method to obtain a tissue diagnosis in patients with interstitial lung disease (ILD). The diagnostic yield of TBLC compared to surgical lung biopsy (SLB) remains uncertain. OBJ ... Full text Link to item Cite

Talc and mesothelioma: mineral fiber analysis of 65 cases with clinicopathological correlation.

Journal Article Ultrastruct Pathol · March 3, 2020 Malignant mesothelioma is strongly associated with prior asbestos exposure. Recently there has been interest in the role of talc exposure in the pathogenesis of mesothelioma. We have analyzed lung tissue samples from a large series of malignant mesotheliom ... Full text Link to item Cite

Overview and Challenges of Bronchiolar Disorders.

Journal Article Ann Am Thorac Soc · March 2020 Bronchiolar abnormalities are common and can occur in conditions that affect either the large airways or the more distal parenchyma. In this review, we focus on the diagnosis and management of primary bronchiolar disorders, or conditions in which bronchiol ... Full text Link to item Cite

Localized malignant mesothelioma, an unusual and poorly characterized neoplasm of serosal origin: best current evidence from the literature and the International Mesothelioma Panel.

Journal Article Mod Pathol · February 2020 Localized malignant mesotheliomas (LMM) is an uncommon and poorly recognized neoplasm. Its pathologic diagnosis is often surprising in patients with serosal/subserosal based localized tumors that are clinically suspicious for metastatic lesions or primary ... Full text Link to item Cite

Parenteral administration of oral medications in lung transplant recipients: An underrecognized problem.

Journal Article Am J Transplant · May 2019 Microcrystalline cellulose (MCC) is an insoluble material commonly used as a binder and filler in oral medications. Identification of pulmonary intravascular deposition of MCC in transbronchial biopsies from lung transplant (LT) recipients following parent ... Full text Link to item Cite

Novel intronic DICER1 variation associated with pleuropulmonary blastoma in two siblings.

Journal Article BMJ Case Rep · January 20, 2019 Pleuropulmonary blastomas (PPB) are rare aggressive paediatric lung malignancies associated with DICER1 variants. We present two cases, a 2-year-old girl with upper respiratory tract symptoms as well as a 6-month-old girl sibling undergoing screening due t ... Full text Link to item Cite

Dusting off the numbers of in situ particle analysis: a 35-year experience.

Journal Article Ultrastruct Pathol · 2019 A variety of fibrotic lung diseases are caused by the inhalation of organic dusts. Many of these disorders have distinctive histopathology and can be readily diagnosed by routine histopathologic examination. However, in some instances, there is overlap in ... Full text Link to item Cite

Large mesenteric lymphangioma in an adult patient: an unusual presentation of a rare disease.

Journal Article BMJ Case Rep · October 7, 2018 Lymphangiomas are most commonly described as a small painless mass in the neck or a vesicular rash in an infant patient. Ninety per cent of cases are diagnosed before the age of 2. Treatment usually involves surgical resection. Intra-abdominal lymphangioma ... Full text Link to item Cite

Metastatic squamous cell carcinoma with pseudoangiosarcomatous features and aberrant expression of vascular markers.

Journal Article Pathol Res Pract · October 2018 Squamous cell carcinoma with pseudoangiosarcomatous features is a rare but well-recognized variant of squamous cell carcinoma. These tumors exhibit complex anastomosing channels lined by neoplastic cells, histologically mimicking a vasoformative mesenchyma ... Full text Link to item Cite

Dendriform pulmonary ossification leading to bilateral lung transplant: a case report.

Journal Article Virchows Arch · September 2018 Metaplastic ossification within the lung is seen in a variety of diseases, usually as sequela of either a separate primary pulmonary parenchymal disease or an underlying cardiac disorder such as valvular disease. Primary intraalveolar ossification or ossif ... Full text Link to item Cite

Mesothelioma Pathology

Chapter · 2017 Cite

Aluminum-induced pneumoconiosis confirmed by analytical scanning electron microscopy: A case report and review of the literature.

Journal Article Ultrastruct Pathol · 2016 Aluminum-induced lung injury is an uncommon, yet recognized pneumoconiosis capable of causing severe interstitial fibrosis. Important attention to the clinical history including occupational exposure is an essential component to making the correct diagnosi ... Full text Link to item Cite

Isoform-Specific Effects of Wild-Type Ras Genes on Carcinogen-Induced Lung Tumorigenesis in Mice.

Journal Article PLoS One · 2016 The gene KRAS is commonly mutated in lung cancer to encode a constitutively active and oncogenic protein that is well established to initiate and maintain lung tumorigenesis. However, the remaining wild-type KRAS protein, or the other family members HRAS a ... Full text Link to item Cite

Persistent thrombocytopaenia in a young man with splenomegaly, rebound thrombocytosis after splenectomy and subsequent pulmonary embolism: splenic littoral cell angioma and associated events.

Journal Article BMJ Case Rep · November 24, 2015 Littoral cell angioma (LCA) is a rare endothelial cell neoplasm in the spleen. Although many cases of LCA are asymptomatic, some present with signs and symptoms related to splenomegaly, whereas others manifest with haematological abnormalities, including a ... Full text Link to item Cite

The diagnosis of asbestosis in the 21st century: a clinicopathological correlation of 102 cases.

Journal Article Ultrastruct Pathol · March 3, 2024 Asbestosis, defined as diffuse pulmonary fibrosis caused by inhalation of asbestos fibers, occurs after heavy exposures to asbestos dust over several decades. Because workplace exposures have been significantly curtailed since the banning of asbestos in in ... Full text Link to item Cite

The over diagnosis of diffuse mesothelioma: An analysis of 311 cases with recommendations for the avoidance of pitfalls.

Journal Article Ann Diagn Pathol · February 2024 BACKGROUND: The diagnosis of mesothelioma may be challenging. We investigated a large database of cases in order to determine the frequency with which a diagnosis of mesothelioma was made incorrectly and the most frequent causes of error. DESIGN: A databas ... Full text Link to item Cite

Chronological trends in the causation of malignant mesothelioma: Fiber burden analysis of 619 cases over four decades.

Journal Article Environ Res · August 1, 2023 Malignant mesothelioma is a relatively rare malignancy with a strong association with prior asbestos exposure. A percentage of cases is not related to asbestos, and fiber analysis of lung tissue is a useful methodology for identifying idiopathic or spontan ... Full text Link to item Cite

Comparison of Forceps, Cryoprobe, and Thoracoscopic Lung Biopsy for the Diagnosis of Interstitial Lung Disease - The CHILL Study.

Journal Article Respiration · 2022 RATIONALE: Transbronchial lung cryobiopsy (TBLC) has emerged as a less invasive method to obtain a tissue diagnosis in patients with interstitial lung disease (ILD). The diagnostic yield of TBLC compared to surgical lung biopsy (SLB) remains uncertain. OBJ ... Full text Link to item Cite

Talc and mesothelioma: mineral fiber analysis of 65 cases with clinicopathological correlation.

Journal Article Ultrastruct Pathol · March 3, 2020 Malignant mesothelioma is strongly associated with prior asbestos exposure. Recently there has been interest in the role of talc exposure in the pathogenesis of mesothelioma. We have analyzed lung tissue samples from a large series of malignant mesotheliom ... Full text Link to item Cite

Overview and Challenges of Bronchiolar Disorders.

Journal Article Ann Am Thorac Soc · March 2020 Bronchiolar abnormalities are common and can occur in conditions that affect either the large airways or the more distal parenchyma. In this review, we focus on the diagnosis and management of primary bronchiolar disorders, or conditions in which bronchiol ... Full text Link to item Cite

Localized malignant mesothelioma, an unusual and poorly characterized neoplasm of serosal origin: best current evidence from the literature and the International Mesothelioma Panel.

Journal Article Mod Pathol · February 2020 Localized malignant mesotheliomas (LMM) is an uncommon and poorly recognized neoplasm. Its pathologic diagnosis is often surprising in patients with serosal/subserosal based localized tumors that are clinically suspicious for metastatic lesions or primary ... Full text Link to item Cite

Parenteral administration of oral medications in lung transplant recipients: An underrecognized problem.

Journal Article Am J Transplant · May 2019 Microcrystalline cellulose (MCC) is an insoluble material commonly used as a binder and filler in oral medications. Identification of pulmonary intravascular deposition of MCC in transbronchial biopsies from lung transplant (LT) recipients following parent ... Full text Link to item Cite

Novel intronic DICER1 variation associated with pleuropulmonary blastoma in two siblings.

Journal Article BMJ Case Rep · January 20, 2019 Pleuropulmonary blastomas (PPB) are rare aggressive paediatric lung malignancies associated with DICER1 variants. We present two cases, a 2-year-old girl with upper respiratory tract symptoms as well as a 6-month-old girl sibling undergoing screening due t ... Full text Link to item Cite

Dusting off the numbers of in situ particle analysis: a 35-year experience.

Journal Article Ultrastruct Pathol · 2019 A variety of fibrotic lung diseases are caused by the inhalation of organic dusts. Many of these disorders have distinctive histopathology and can be readily diagnosed by routine histopathologic examination. However, in some instances, there is overlap in ... Full text Link to item Cite

Large mesenteric lymphangioma in an adult patient: an unusual presentation of a rare disease.

Journal Article BMJ Case Rep · October 7, 2018 Lymphangiomas are most commonly described as a small painless mass in the neck or a vesicular rash in an infant patient. Ninety per cent of cases are diagnosed before the age of 2. Treatment usually involves surgical resection. Intra-abdominal lymphangioma ... Full text Link to item Cite

Metastatic squamous cell carcinoma with pseudoangiosarcomatous features and aberrant expression of vascular markers.

Journal Article Pathol Res Pract · October 2018 Squamous cell carcinoma with pseudoangiosarcomatous features is a rare but well-recognized variant of squamous cell carcinoma. These tumors exhibit complex anastomosing channels lined by neoplastic cells, histologically mimicking a vasoformative mesenchyma ... Full text Link to item Cite

Dendriform pulmonary ossification leading to bilateral lung transplant: a case report.

Journal Article Virchows Arch · September 2018 Metaplastic ossification within the lung is seen in a variety of diseases, usually as sequela of either a separate primary pulmonary parenchymal disease or an underlying cardiac disorder such as valvular disease. Primary intraalveolar ossification or ossif ... Full text Link to item Cite

Mesothelioma Pathology

Chapter · 2017 Cite

Aluminum-induced pneumoconiosis confirmed by analytical scanning electron microscopy: A case report and review of the literature.

Journal Article Ultrastruct Pathol · 2016 Aluminum-induced lung injury is an uncommon, yet recognized pneumoconiosis capable of causing severe interstitial fibrosis. Important attention to the clinical history including occupational exposure is an essential component to making the correct diagnosi ... Full text Link to item Cite

Isoform-Specific Effects of Wild-Type Ras Genes on Carcinogen-Induced Lung Tumorigenesis in Mice.

Journal Article PLoS One · 2016 The gene KRAS is commonly mutated in lung cancer to encode a constitutively active and oncogenic protein that is well established to initiate and maintain lung tumorigenesis. However, the remaining wild-type KRAS protein, or the other family members HRAS a ... Full text Link to item Cite

Persistent thrombocytopaenia in a young man with splenomegaly, rebound thrombocytosis after splenectomy and subsequent pulmonary embolism: splenic littoral cell angioma and associated events.

Journal Article BMJ Case Rep · November 24, 2015 Littoral cell angioma (LCA) is a rare endothelial cell neoplasm in the spleen. Although many cases of LCA are asymptomatic, some present with signs and symptoms related to splenomegaly, whereas others manifest with haematological abnormalities, including a ... Full text Link to item Cite

Immunostaining in lung cancer for the clinician. Commonly used markers for differentiating primary and metastatic pulmonary tumors.

Journal Article Ann Am Thorac Soc · March 2015 Immunohistochemical stains have become invaluable for the diagnosis of pulmonary malignancies (both primary and metastatic), particularly given the small size of transbronchial and endobronchial biopsies and the increasing need to conserve tissue for molec ... Full text Link to item Cite

Decreased tumorigenesis in mice with a Kras point mutation at C118.

Journal Article Nat Commun · November 14, 2014 KRAS, NRAS or HRAS genes are mutated to encode an active oncogenic protein in a quarter of human cancers. Redox-dependent reactions can also lead to Ras activation in a manner dependent upon the thiol residue of cysteine 118 (C118). Here, to investigate th ... Full text Link to item Cite