John Hunter Peel Alexander
Professor of Medicine
John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.
Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.
Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).
Current Appointments & Affiliations
- Professor of Medicine, Medicine, Cardiology, Medicine 2014
- Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 1996
Contact Information
- 200 Morris Street, Durham, NC 27701
- Duke Box 17969, Durham, NC 27715
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john.h.alexander@duke.edu
(919) 668-8955
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DCRI Profile
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Department of Medicine (Cardiology) Profile
- Background
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Education, Training, & Certifications
- Fellow in Cardiology, Medicine, Duke University 1996 - 2000
- Medical Resident, Medicine, Children's Hospital, Boston 1993 - 1996
- M.D., University of Pennsylvania 1993
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Previous Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2010 - 2014
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2006 - 2010
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2000 - 2006
- Recognition
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In the News
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MAR 10, 2023 Duke Health News -
MAR 20, 2017 Duke Health News
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- Expertise
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Subject Headings
- Academic Medical Centers
- Acute Coronary Syndrome
- Acute Disease
- Administration, Oral
- Adolescent
- Adrenergic beta-Antagonists
- Adult
- African Americans
- Age Distribution
- Age Factors
- Aged
- Aged, 80 and over
- Algorithms
- Amiodarone
- Anastomosis, Surgical
- Angina, Unstable
- Angiography
- Angioplasty, Balloon, Coronary
- Angiotensin II Type 1 Receptor Blockers
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors
- Animals
- Anti-Arrhythmia Agents
- Antibodies, Monoclonal
- Anticoagulants
- Antithrombin III
- Antithrombins
- Aptamers, Nucleotide
- Arginine
- Aspirin
- Atrial Fibrillation
- Benzimidazoles
- Biological Markers
- Blood Coagulation
- Blood Coagulation Tests
- Blood Glucose
- Blood Platelets
- Blood Pressure
- Blood Vessel Prosthesis
- Blotting, Western
- Body Mass Index
- Body Weight
- Brazil
- Carbazoles
- Cardiac Catheterization
- Cardiac Pacing, Artificial
- Cardiac Surgical Procedures
- Cardiopulmonary Bypass
- Cardiotonic Agents
- Cardiovascular Agents
- Cardiovascular Diseases
- Catheter Ablation
- Cause of Death
- Cells, Cultured
- Cerebrovascular Disorders
- Chest Pain
- Chi-Square Distribution
- Chromatography, Liquid
- Chronic Disease
- Clinical Protocols
- Clinical Trials as Topic
- Clinical Trials, Phase II as Topic
- Clinical Trials, Phase III as Topic
- Clopidogrel
- Cohort Studies
- Combined Modality Therapy
- Communication
- Comorbidity
- Confidence Intervals
- Confounding Factors (Epidemiology)
- Congresses as Topic
- Coronary Angiography
- Coronary Artery Bypass
- Coronary Artery Bypass, Off-Pump
- Coronary Artery Disease
- Coronary Disease
- Coronary Stenosis
- Coronary Vessels
- Costs and Cost Analysis
- Creatine Kinase
- Creatine Kinase, MB Form
- Cyclic N-Oxides
- DNA
- Data Collection
- Data Interpretation, Statistical
- Databases, Factual
- Defibrillators, Implantable
- Delivery of Health Care
- Device Removal
- Diabetes Complications
- Diabetes Mellitus
- Diabetes Mellitus, Type 2
- Diagnosis, Differential
- Disease-Free Survival
- Dose-Response Relationship, Drug
- Double-Blind Method
- Down-Regulation
- Drug Administration Schedule
- Drug Combinations
- Drug Design
- Drug Prescriptions
- Drug Therapy, Combination
- Drug Toxicity
- E2F Transcription Factors
- Echocardiography
- Education, Medical, Continuing
- Electric Countershock
- Electrocardiography
- Electrophoresis, Polyacrylamide Gel
- Embolism
- Endoscopy
- Endothelium, Vascular
- Enoxaparin
- Enzyme Inhibitors
- Enzyme-Linked Immunosorbent Assay
- Epitopes
- Equipment Design
- Europe
- European Continental Ancestry Group
- Evidence-Based Medicine
- Exercise Test
- Factor IX
- Factor IXa
- Factor Xa
- Far East
- Feasibility Studies
- Female
- Fibrin Fibrinogen Degradation Products
- Fibrinolytic Agents
- Follow-Up Studies
- Gastrointestinal Diseases
- Genetic Engineering
- Genetic Predisposition to Disease
- Genetic Therapy
- Genotype
- Glycated Hemoglobin A
- Graft Occlusion, Vascular
- Graft Rejection
- Graft Survival
- Guideline Adherence
- Health Plan Implementation
- Health Services Accessibility
- Heart Block
- Heart Defects, Congenital
- Heart Diseases
- Heart Failure
- Heart Valve Diseases
- Heart Valve Prosthesis
- Heart Valve Prosthesis Implantation
- Hemodynamics
- Hemorrhage
- Heparin
- Heparin, Low-Molecular-Weight
- Hospitalization
- Hospitals, University
- Humans
- Hydrazones
- Hyperplasia
- Hypertension
- Hypoglycemic Agents
- Immunoglobulin Fab Fragments
- Immunoprecipitation
- Incidence
- Infusions, Intravenous
- Injections, Intravenous
- Injections, Subcutaneous
- Internal Medicine
- International Cooperation
- International Normalized Ratio
- Intracranial Hemorrhages
- Intraoperative Care
- Ischemia
- Isoenzymes
- Japan
- Kaplan-Meier Estimate
- Kidney Diseases
- Lidocaine
- Longitudinal Studies
- Male
- Medical Staff, Hospital
- Medicare
- Medication Errors
- Meta-Analysis
- Middle Aged
- Mineralocorticoid Receptor Antagonists
- Mitral Valve Insufficiency
- Models, Theoretical
- Monitoring, Physiologic
- Mortality
- Multicenter Studies as Topic
- Myoblasts, Skeletal
- Myocardial Ischemia
- Myocardial Revascularization
- Myocardium
- Naphthalenes
- Neoplasms
- New Zealand
- Nitric Oxide Synthase
- North Carolina
- Obesity
- Odds Ratio
- Oligonucleotides
- Organ Preservation Solutions
- Partial Thromboplastin Time
- Patient Readmission
- Patient Selection
- Peptide Fragments
- Peptides
- Percutaneous Coronary Intervention
- Pericardial Effusion
- Perioperative Care
- Peripheral Vascular Diseases
- Pharmacokinetics
- Physical Examination
- Physician's Practice Patterns
- Physicians
- Pilot Projects
- Placebo Effect
- Placebos
- Platelet Aggregation Inhibitors
- Platelet Factor 4
- Point-of-Care Systems
- Polysaccharides
- Postoperative Care
- Postoperative Complications
- Postoperative Hemorrhage
- Postoperative Period
- Practice Guidelines as Topic
- Predictive Value of Tests
- Premedication
- Probability
- Prognosis
- Proportional Hazards Models
- Prospective Studies
- Prosthesis Design
- Protective Agents
- Protein Binding
- Protein Isoforms
- Protein Precursors
- Prothrombin
- Publication Bias
- Pulmonary Disease, Chronic Obstructive
- Pyrazoles
- Pyridazines
- Pyridines
- Pyridones
- Pyridoxal Phosphate
- Quality Assurance, Health Care
- Questionnaires
- Recombinant Proteins
- Recurrence
- Reference Values
- Regional Blood Flow
- Registries
- Regression Analysis
- Renin-Angiotensin System
- Reoperation
- Reproducibility of Results
- Research Design
- Retrospective Studies
- Risk
- Risk Assessment
- Risk Factors
- Risk Reduction Behavior
- Rupture, Spontaneous
- Saphenous Vein
- Sensitivity and Specificity
- Severity of Illness Index
- Sex Distribution
- Sex Factors
- Shock, Cardiogenic
- Signal Transduction
- Sodium Chloride
- Statistics
- Stents
- Streptokinase
- Stroke
- Sucralfate
- Surgical Procedures, Operative
- Surgical Wound Infection
- Survival
- Survival Analysis
- Survival Rate
- Syndrome
- Tachycardia, Ventricular
- Tandem Mass Spectrometry
- Thrombin
- Thrombin Time
- Thromboembolism
- Thrombolytic Therapy
- Thromboplastin
- Thrombosis
- Ticlopidine
- Time Factors
- Tissue Plasminogen Activator
- Tissue and Organ Harvesting
- Transfection
- Transplantation, Autologous
- Transplants
- Treatment Failure
- Treatment Outcome
- Troponin
- Troponin I
- Troponin T
- Tunica Intima
- United States
- Urinary Bladder Diseases
- Vascular Diseases
- Vascular Patency
- Vascular Surgical Procedures
- Vasoconstrictor Agents
- Veins
- Vena Cava Filters
- Venous Thromboembolism
- Ventricular Dysfunction, Left
- Ventricular Fibrillation
- Warfarin
- World Health
- Wounds and Injuries
- Young Adult
- beta-Alanine
- omega-N-Methylarginine
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Global Scholarship
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Expertise
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Research
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- Research
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Selected Grants
- Stimulating Access to Research in Residency (StARR) - NHLBI awarded by National Institutes of Health 2018 - 2028
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program awarded by University of North Carolina - Chapel Hill 2016 - 2026
- OCEANIC Site Budget 2023 - 2025
- Increasing the Quality and Efficiency of Clinical Trials (U18) awarded by Food and Drug Administration 2014 - 2024
- Postdoctoral Training in Cardiovascular Clinical Research awarded by National Institutes of Health 2003 - 2024
- CSL112_STEMI 2017 - 2023
- Myocardial Ischemia and Transfusion (MINT) Steering Committee 2016 - 2023
- ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment with Alirocumab 2018 - 2022
- ClotChip 2020 - 2022
- Core Clinical Centers for the CTSN awarded by National Institutes of Health 2007 - 2018
- Genetics Myocardial Adverse Outcomes/Graft Failure-CABG (Gene-Magic) awarded by National Institutes of Health 2004 - 2011
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External Relationships
- AbbVie Pharmaceuticals
- Antev
- Artivion
- Atricure
- Bayer
- Pfizer Inc.
- Portola Pharmaceuticals, Inc.
- Veralox therapeutics
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Hijazi, Ziad, Johan Lindbäck, Jonas Oldgren, Alexander P. Benz, John H. Alexander, Stuart J. Connolly, John W. Eikelboom, et al. “Individual net clinical outcome with oral anticoagulation in atrial fibrillation using the ABC-AF risk scores.” Am Heart J 261 (July 2023): 55–63. https://doi.org/10.1016/j.ahj.2023.03.012.Full Text Link to Item
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Rong, Lisa Q., Antonino Di Franco, Mohamed Rahouma, Arnaldo Dimagli, June Chan, Alexandra J. Lopes, Jiwon Kim, et al. “Postoperative pericardial effusion, pericardiotomy, and atrial fibrillation: An explanatory analysis of the PALACS trial.” Am Heart J 260 (June 2023): 113–23. https://doi.org/10.1016/j.ahj.2023.03.001.Full Text Link to Item
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Alexander, John H. “Benefits of Bempedoic Acid - Clearer Now.” N Engl J Med 388, no. 15 (April 13, 2023): 1425–26. https://doi.org/10.1056/NEJMe2301490.Full Text Link to Item
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Chatterjee, Subhasis, Niv Ad, Vinay Badhwar, A Marc Gillinov, John H. Alexander, and Marc R. Moon. “Anticoagulation for atrial fibrillation after cardiac surgery: Do guidelines reflect the evidence?” J Thorac Cardiovasc Surg, April 8, 2023. https://doi.org/10.1016/j.jtcvs.2023.03.026.Full Text Link to Item
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Chu, Michael W. A., Marc Ruel, Allen Graeve, Marc W. Gerdisch, Ralph J. Damiano, Robert L. Smith, William Brent Keeling, et al. “Low-Dose vs Standard Warfarin After Mechanical Mitral Valve Replacement: A Randomized Trial.” Ann Thorac Surg 115, no. 4 (April 2023): 929–38. https://doi.org/10.1016/j.athoracsur.2022.12.031.Full Text Link to Item
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Milling, Truman J., Saskia Middeldorp, Lizhen Xu, Bruce Koch, Andrew Demchuk, John W. Eikelboom, Peter Verhamme, et al. “Final Study Report of Andexanet Alfa for Major Bleeding With Factor Xa Inhibitors.” Circulation 147, no. 13 (March 28, 2023): 1026–38. https://doi.org/10.1161/CIRCULATIONAHA.121.057844.Full Text Link to Item
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Carson, Jeffrey L., Maria Mori Brooks, Bernard R. Chaitman, John H. Alexander, Shaun G. Goodman, Marnie Bertolet, J Dawn Abbott, et al. “Rationale and design for the myocardial ischemia and transfusion (MINT) randomized clinical trial.” Am Heart J 257 (March 2023): 120–29. https://doi.org/10.1016/j.ahj.2022.11.015.Full Text Link to Item
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Montalescot, Gilles, John H. Alexander, Angel Cequier-Fillat, Scott D. Solomon, Alban Redheuil, Martin Hudec, Johanne Silvain, et al. “Firibastat Versus Ramipril After Acute Mechanical Reperfusion of Anterior Myocardial Infarction: A Phase 2 Study.” Am J Cardiovasc Drugs 23, no. 2 (March 2023): 207–17. https://doi.org/10.1007/s40256-023-00567-8.Full Text Link to Item
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Harrington, Josephine, Jonathan P. Piccini, John H. Alexander, Christopher B. Granger, and Manesh R. Patel. “Clinical Evaluation of Factor XIa Inhibitor Drugs: JACC Review Topic of the Week.” J Am Coll Cardiol 81, no. 8 (February 28, 2023): 771–79. https://doi.org/10.1016/j.jacc.2022.11.057.Full Text Link to Item
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Gaudino, Mario, John Alexander, Umberto Benedetto, Andreas Boening, Arnaldo Dimagli, Stephen Fremes, Joanna Chikwe, et al. “Omnia munda mundis ('to the pure, all things are pure').” Eur J Cardiothorac Surg 63, no. 2 (February 3, 2023). https://doi.org/10.1093/ejcts/ezad021.Full Text Link to Item
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Hijazi, Ziad, Alexander P. Benz, Johan Lindbäck, John H. Alexander, Stuart J. Connolly, John W. Eikelboom, Christopher B. Granger, et al. “Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation.” Eur Heart J 44, no. 3 (January 14, 2023): 208–18. https://doi.org/10.1093/eurheartj/ehac632.Full Text Open Access Copy Link to Item
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Goldstein, Daniel J., Helena L. Chang, Michael J. Mack, Pierre Voisine, James S. Gammie, Mary E. Marks, Alexander Iribarne, et al. “Intimal hyperplasia, saphenous vein graft disease, and clinical outcomes: Insights from the CTSN VEST randomized trial.” J Thorac Cardiovasc Surg, October 30, 2022. https://doi.org/10.1016/j.jtcvs.2022.10.034.Full Text Link to Item
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Rao, Sunil V., Bodo Kirsch, Deepak L. Bhatt, Andrzej Budaj, Rosa Coppolecchia, John Eikelboom, Stefan K. James, et al. “A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction.” Circulation 146, no. 16 (October 18, 2022): 1196–1206. https://doi.org/10.1161/CIRCULATIONAHA.122.061612.Full Text Link to Item
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Al-Khatib, Sana M., Daniel M. Wojdyla, Christopher B. Granger, Lars Wallentin, David A. Garcia, Ziad Hijazi, Claes Held, et al. “Duration of Anticoagulation Interruption Before Invasive Procedures and Outcomes in Patients With Atrial Fibrillation: Insights From the ARISTOTLE Trial.” Circulation 146, no. 12 (September 20, 2022): 958–60. https://doi.org/10.1161/CIRCULATIONAHA.122.059438.Full Text Link to Item
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Attar, Rubina, Angie Wu, Daniel Wojdyla, Svend Eggert Jensen, Pontus Andell, Kenneth W. Mahaffey, Matthew T. Roe, et al. “Outcomes After Acute Coronary Syndrome in Patients With Diabetes Mellitus and Peripheral Artery Disease (from the TRACER, TRILOGY-ACS, APPRAISE-2, and PLATO Clinical Trials).” Am J Cardiol 178 (September 1, 2022): 11–17. https://doi.org/10.1016/j.amjcard.2022.04.062.Full Text Link to Item
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Aulin, Julia, Ziad Hijazi, Johan Lindbäck, John H. Alexander, Bernard J. Gersh, Christopher B. Granger, Michael Hanna, et al. “Biomarkers and heart failure events in patients with atrial fibrillation in the ARISTOTLE trial evaluated by a multi-state model.” Am Heart J 251 (September 2022): 13–24. https://doi.org/10.1016/j.ahj.2022.03.009.Full Text Link to Item
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Caruba, Thibaut, Anaïs Charles-Nelson, John H. Alexander, Rajendra H. Mehta, Matthias Heringlake, Wolfgang Toller, Amelie Yavchitz, Brigitte Sabatier, Gilles Chatellier, and Bernard Cholley. “Prophylactic levosimendan in patients with low ejection fraction undergoing coronary artery bypass grafting: A pooled analysis of two multicentre randomised controlled trials.” Anaesth Crit Care Pain Med 41, no. 4 (August 2022): 101107. https://doi.org/10.1016/j.accpm.2022.101107.Full Text Link to Item
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Goldstein, Daniel J., John D. Puskas, John H. Alexander, Helena L. Chang, James S. Gammie, Mary E. Marks, Alexander Iribarne, et al. “External Support for Saphenous Vein Grafts in Coronary Artery Bypass Surgery: A Randomized Clinical Trial.” Jama Cardiol 7, no. 8 (August 1, 2022): 808–16. https://doi.org/10.1001/jamacardio.2022.1437.Full Text Link to Item
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Pol, Tymon, Ziad Hijazi, Johan Lindbäck, Jonas Oldgren, John H. Alexander, Stuart J. Connolly, John W. Eikelboom, et al. “Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation.” Cardiovasc Res 118, no. 9 (July 20, 2022): 2112–23. https://doi.org/10.1093/cvr/cvab262.Full Text Link to Item
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Bahit, M Cecilia, Amit N. Vora, Zhuokai Li, Daniel M. Wojdyla, Laine Thomas, Shaun G. Goodman, Ronald Aronson, et al. “Apixaban or Warfarin and Aspirin or Placebo After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Patients With Atrial Fibrillation and Prior Stroke: A Post Hoc Analysis From the AUGUSTUS Trial.” Jama Cardiol 7, no. 7 (July 1, 2022): 682–89. https://doi.org/10.1001/jamacardio.2022.1166.Full Text Link to Item
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Macedo, Ariane Vieira Scarlatelli, Pedro Gabriel Melo de Barros E Silva, Thiago Ceccatto de Paula, Renata Junqueira Moll-Bernardes, Tiago Mendonça Dos Santos, Lilian Mazza, Andre Feldman, et al. “Discontinuing vs continuing ACEIs and ARBs in hospitalized patients with COVID-19 according to disease severity: Insights from the BRACE CORONA trial.” Am Heart J 249 (July 2022): 86–97. https://doi.org/10.1016/j.ahj.2022.04.001.Full Text Link to Item
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Gaudino, Mario, Katia Audisio, Antonino Di Franco, John H. Alexander, Paul Kurlansky, Andreas Boening, Joanna Chikwe, et al. “Radial artery versus saphenous vein versus right internal thoracic artery for coronary artery bypass grafting.” Eur J Cardiothorac Surg 62, no. 1 (June 15, 2022). https://doi.org/10.1093/ejcts/ezac345.Full Text Link to Item
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Verma, Sanam, Sarah Rathwell, Stephen Fremes, Yinggan Zheng, Rajendra Mehta, Renato D. Lopes, John H. Alexander, Shaun G. Goodman, Sean van Diepen, and Sean van LEVO-CTS investigators. “Associated factors and clinical outcomes in mechanical circulatory support use in patients undergoing high risk on-pump cardiac surgery: Insights from the LEVO-CTS trial.” Am Heart J 248 (June 2022): 35–41. https://doi.org/10.1016/j.ahj.2022.02.013.Full Text Link to Item
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De Caterina, Raffaele, Giuseppe Patti, Johan Westerbergh, John Horowitz, Justin A. Ezekowitz, Basil S. Lewis, Renato D. Lopes, et al. “Heterogeneity of diabetes as a risk factor for major adverse cardiovascular events in anticoagulated patients with atrial fibrillation: an analysis of the ARISTOTLE trial.” Eur Heart J Cardiovasc Pharmacother 8, no. 3 (May 5, 2022): 227–35. https://doi.org/10.1093/ehjcvp/pvaa140.Full Text Link to Item
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Bagiella, Emilia, John D. Puskas, Alan J. Moskowitz, Annetine C. Gelijns, John H. Alexander, Jagat Narula, Peter K. Smith, et al. “Rationale and design of a randomized trial evaluating an external support device for saphenous vein coronary grafts.” Am Heart J 246 (April 2022): 12–20. https://doi.org/10.1016/j.ahj.2021.12.009.Full Text Link to Item
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Alexander, John H. “Equipoise in Clinical Trials: Enough Uncertainty in Whose Opinion?” Circulation 145, no. 13 (March 29, 2022): 943–45. https://doi.org/10.1161/CIRCULATIONAHA.121.057201.Full Text Link to Item
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Harskamp, Ralf E., Alexander C. Fanaroff, Renato D. Lopes, Daniel M. Wojdyla, Shaun G. Goodman, Laine E. Thomas, Ronald Aronson, et al. “Antithrombotic Therapy in Patients With Atrial Fibrillation After Acute Coronary Syndromes or Percutaneous Intervention.” J Am Coll Cardiol 79, no. 5 (February 8, 2022): 417–27. https://doi.org/10.1016/j.jacc.2021.11.035.Full Text Link to Item
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Welsh, Robert C., Payam Dehghani, Renato Lopes, Daniel M. Wojdyla, Ronald Aronson, Christopher B. Granger, Stephan Windecker, et al. “Impact of prior oral anticoagulant use and outcomes on patients from secondary analysis in the AUGUSTUS trial.” Open Heart 9, no. 1 (February 2022). https://doi.org/10.1136/openhrt-2021-001892.Full Text Link to Item
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Carnicelli, Anthony P., Hwanhee Hong, Stuart J. Connolly, John Eikelboom, Robert P. Giugliano, David A. Morrow, Manesh R. Patel, et al. “Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex.” Circulation 145, no. 4 (January 25, 2022): 242–55. https://doi.org/10.1161/CIRCULATIONAHA.121.056355.Full Text Link to Item
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Attelind, Sofia, Pär Hallberg, Mia Wadelius, Anna-Karin Hamberg, Agneta Siegbahn, Christopher B. Granger, Renato D. Lopes, John H. Alexander, Lars Wallentin, and Niclas Eriksson. “Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events.” Front Genet 13 (2022): 982955. https://doi.org/10.3389/fgene.2022.982955.Full Text Link to Item
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Gaudino, Mario, Antonino Di Franco, John H. Alexander, Faisal Bakaeen, Natalia Egorova, Paul Kurlansky, Andreas Boening, et al. “Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data.” Eur Heart J 43, no. 1 (December 28, 2021): 18–28. https://doi.org/10.1093/eurheartj/ehab504.Full Text Link to Item
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Fudim, Marat, Daniel M. Wojdyla, John H. Alexander, Shaun G. Goodman, Roxana Mehran, Stephan Windecker, Ronald Aronson, et al. “Efficacy and Safety of Antithrombotic Therapy in Patients With Atrial Fibrillation, Recent Acute Coronary Syndrome, or Percutaneous Coronary Intervention and a History of Heart Failure: Insights From the AUGUSTUS Trial.” J Am Heart Assoc 10, no. 24 (December 21, 2021): e023143. https://doi.org/10.1161/JAHA.121.023143.Full Text Link to Item
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Gelijns, Annetine C., Alan J. Moskowitz, Patrick T. O’Gara, Gennaro Giustino, Michael J. Mack, Donna M. Mancini, Emilia Bagiella, et al. “Transcatheter mitral valve repair for functional mitral regurgitation: Evaluating the evidence.” J Thorac Cardiovasc Surg 162, no. 5 (November 2021): 1504–11. https://doi.org/10.1016/j.jtcvs.2020.02.132.Full Text Link to Item
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Siegbahn, Agneta, Johan Lindbäck, Ziad Hijazi, Mikael Åberg, John H. Alexander, John W. Eikelboom, Renato D. Lopes, et al. “Multiplex protein screening of biomarkers associated with major bleeding in patients with atrial fibrillation treated with oral anticoagulation.” J Thromb Haemost 19, no. 11 (November 2021): 2726–37. https://doi.org/10.1111/jth.15498.Full Text Link to Item
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Lopes, Renato D., Celestia S. Higano, Susan F. Slovin, Adam J. Nelson, Robert Bigelow, Per S. Sørensen, Chiara Melloni, et al. “Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial.” Circulation 144, no. 16 (October 19, 2021): 1295–1307. https://doi.org/10.1161/CIRCULATIONAHA.121.056810.Full Text Link to Item
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Lopes, Renato D., Pedro Gabriel Melo de Barros E Silva, Remo H. M. Furtado, John H. Alexander, and Otavio Berwanger. “Age-adjusted D-dimer cutoffs to guide anticoagulation in COVID-19 - Authors' reply.” Lancet 398, no. 10308 (October 9, 2021): 1304. https://doi.org/10.1016/S0140-6736(21)01909-7.Full Text Link to Item
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Wanner, C., M. E. Cooper, O. E. Johansen, R. Toto, J. Rosenstock, D. K. McGuire, S. E. Kahn, et al. “Erratum to: Effect of linagliptin versus placebo on cardiovascular and kidney outcomes in nephroticrange proteinuria and type 2 diabetes (t2d): the carmelina randomised controlled trial (Clinical Kidney Journal (sfaa225) DOI: 10.1093/ckj/sfaa225).” Clinical Kidney Journal 14, no. 9 (September 1, 2021): 2136. https://doi.org/10.1093/ckj/sfab104.Full Text
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Schwartz, Gregory G., Michael Szarek, Vera A. Bittner, Rafael Diaz, Shaun G. Goodman, J Wouter Jukema, Ulf Landmesser, et al. “Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol.” J Am Coll Cardiol 78, no. 5 (August 3, 2021): 421–33. https://doi.org/10.1016/j.jacc.2021.04.102.Full Text Link to Item
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Lopes, Renato D., Pedro Gabriel Melo de Barros E Silva, Remo H. M. Furtado, Ariane Vieira Scarlatelli Macedo, Eduardo Ramacciotti, Lucas Petri Damini, Bruna Bronhara, et al. “Randomized clinical trial to evaluate a routine full anticoagulation Strategy in Patients with Coronavirus Infection (SARS-CoV2) admitted to hospital: Rationale and design of the ACTION (AntiCoagulaTlon cOroNavirus)-Coalition IV trial.” Am Heart J 238 (August 2021): 1–11. https://doi.org/10.1016/j.ahj.2021.04.005.Full Text Open Access Copy Link to Item
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Goyal, Akash, Tony Schibler, Brooke Alhanti, Karen L. Hannan, Christopher B. Granger, Michael A. Blazing, Renato D. Lopes, et al. “Assessment of North American Clinical Research Site Performance During the Start-up of Large Cardiovascular Clinical Trials.” Jama Netw Open 4, no. 7 (July 1, 2021): e2117963. https://doi.org/10.1001/jamanetworkopen.2021.17963.Full Text Link to Item
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Alexander, John H., Daniel Wojdyla, Amit N. Vora, Laine Thomas, Christopher B. Granger, Shaun G. Goodman, Ronald Aronson, Stephan Windecker, Roxana Mehran, and Renato D. Lopes. “Risk/Benefit Tradeoff of Antithrombotic Therapy in Patients With Atrial Fibrillation Early and Late After an Acute Coronary Syndrome or Percutaneous Coronary Intervention: Insights From AUGUSTUS.” Circulation 141, no. 20 (May 19, 2020): 1618–27. https://doi.org/10.1161/CIRCULATIONAHA.120.046534.Full Text Link to Item
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Lopes, Renato D., Ariane Vieira Scarlatelli Macedo, Pedro Gabriel Melo de Barros E Silva, Renata Junqueira Moll-Bernardes, Andre Feldman, Guilherme D’Andréa Saba Arruda, Andrea Silvestre de Souza, et al. “Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).” Am Heart J, May 13, 2020. https://doi.org/10.1016/j.ahj.2020.05.002.Full Text Open Access Copy Link to Item
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Marquis-Gravel, Guillaume, Zhen Huang, Steven L. Zelenkofske, A Michael Lincoff, Roxana Mehran, P Gabriel Steg, Christoph Bode, John H. Alexander, and Thomas J. Povsic. “Interplay between PCI access site, anticoagulant agent, and bleeding: Insights from the REGULATE-PCI randomized trial.” Am Heart J 223 (May 2020): 84–86. https://doi.org/10.1016/j.ahj.2020.02.013.Full Text Link to Item
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Lopes, Renato D., Hwanhee Hong, Ralf E. Harskamp, Deepak L. Bhatt, Roxana Mehran, Christopher P. Cannon, Christopher B. Granger, et al. “Optimal Antithrombotic Regimens for Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: An Updated Network Meta-analysis.” Jama Cardiol 5, no. 5 (May 1, 2020): 582–89. https://doi.org/10.1001/jamacardio.2019.6175.Full Text Link to Item
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Zeitouni, Michel, Anna Giczewska, Renato D. Lopes, Daniel M. Wojdyla, Christina Christersson, Agneta Siegbahn, Raffaele De Caterina, et al. “Clinical and Pharmacological Effects of Apixaban Dose Adjustment in the ARISTOTLE Trial.” J Am Coll Cardiol 75, no. 10 (March 17, 2020): 1145–55. https://doi.org/10.1016/j.jacc.2019.12.060.Full Text Link to Item
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Lopes, Renato D., Pedro G. M. de Barros E Silva, Lucas Petri Damiani, Renato Hideo Nakagawa Santos, John H. Alexander, Christopher B. Granger, and Otavio Berwanger. “Major Adverse Cardiovascular Events After 12 Months Among Patients With Acute Coronary Syndrome Receiving Loading Doses of Atorvastatin Prior to Planned PCI.” Jama 323, no. 8 (February 25, 2020): 787–89. https://doi.org/10.1001/jama.2020.0118.Full Text Link to Item
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Dalgaard, Frederik, Hillary Mulder, Daniel M. Wojdyla, Renato D. Lopes, Claes Held, John H. Alexander, Raffaele De Caterina, et al. “Patients With Atrial Fibrillation Taking Nonsteroidal Anti-Inflammatory Drugs and Oral Anticoagulants in the ARISTOTLE Trial.” Circulation 141, no. 1 (January 7, 2020): 10–20. https://doi.org/10.1161/CIRCULATIONAHA.119.041296.Full Text Link to Item
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Harskamp, Ralf E., John H. Alexander, and Renato D. Lopes. “Clinical Considerations Prior to Transition From Triple Antithrombotic Therapy to Dual Antithrombotic Therapy-Reply.” Jama Cardiol 5, no. 1 (January 1, 2020): 111–12. https://doi.org/10.1001/jamacardio.2019.4551.Full Text Link to Item
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Lopes, Renato D., Hwanhee Hong, and John H. Alexander. “Antithrombotic therapy after acute coronary syndrome and/or percutaneous coronary intervention in atrial fibrillation: finding the sweet spot.” Eur Heart J 40, no. 46 (December 7, 2019): 3768–70. https://doi.org/10.1093/eurheartj/ehz823.Full Text Link to Item
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Vora, Amit N., John H. Alexander, Daniel M. Wojdyla, Ronald Aronson, Christopher B. Granger, Harald Darius, Stephan Windecker, et al. “Hospitalization Among Patients With Atrial Fibrillation and a Recent Acute Coronary Syndrome or Percutaneous Coronary Intervention Treated With Apixaban or Aspirin: Insights From the AUGUSTUS Trial.” Circulation 140, no. 23 (December 3, 2019): 1960–63. https://doi.org/10.1161/CIRCULATIONAHA.119.043754.Full Text Link to Item
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Windecker, Stephan, Renato D. Lopes, Tyler Massaro, Charlotte Jones-Burton, Christopher B. Granger, Ronald Aronson, Gretchen Heizer, et al. “Antithrombotic Therapy in Patients With Atrial Fibrillation and Acute Coronary Syndrome Treated Medically or With Percutaneous Coronary Intervention or Undergoing Elective Percutaneous Coronary Intervention: Insights From the AUGUSTUS Trial.” Circulation 140, no. 23 (December 3, 2019): 1921–32. https://doi.org/10.1161/CIRCULATIONAHA.119.043308.Full Text Link to Item
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Brennan, J Matthew, Lisa Wruck, Michael J. Pencina, Robert M. Clare, Renato D. Lopes, John H. Alexander, Sean O’Brien, et al. “Claims-based cardiovascular outcome identification for clinical research: Results from 7 large randomized cardiovascular clinical trials.” Am Heart J 218 (December 2019): 110–22. https://doi.org/10.1016/j.ahj.2019.09.002.Full Text Link to Item
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Nelson, Adam J., and John H. Alexander. “Anticoagulation-Related Major Bleeding in Patients With Atrial Fibrillation: Looking Behind the Curtain.” Circulation 140, no. 22 (November 26, 2019): 1802–4. https://doi.org/10.1161/CIRCULATIONAHA.119.043318.Full Text Link to Item
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Goldstein, Sarah A., Jennifer Green, Kurt Huber, Daniel M. Wojdyla, Renato D. Lopes, John H. Alexander, Dragos Vinereanu, Lars Wallentin, Christopher B. Granger, and Sana M. Al-Khatib. “Characteristics and Outcomes of Atrial Fibrillation in Patients With Thyroid Disease (from the ARISTOTLE Trial).” Am J Cardiol 124, no. 9 (November 1, 2019): 1406–12. https://doi.org/10.1016/j.amjcard.2019.07.046.Full Text Link to Item
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Alexander, Karen P., and John H. Alexander. “Safe and Effective Anticoagulation: What Does Drug Concentration Add?” J Am Geriatr Soc 67, no. 9 (September 2019): 1772–73. https://doi.org/10.1111/jgs.15981.Full Text Link to Item
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Sharma, Abhinav, Emil Hagström, Daniel M. Wojdyla, Megan L. Neely, Robert A. Harrington, Lars Wallentin, John H. Alexander, Shaun G. Goodman, Renato D. Lopes, and Renato D. Apixaban for Prevention of Acute Ischemic Safety Events APPRAISE-2 Steering Committee and Investigators. “Clinical consequences of bleeding among individuals with a recent acute coronary syndrome: Insights from the APPRAISE-2 trial.” Am Heart J 215 (September 2019): 106–13. https://doi.org/10.1016/j.ahj.2019.05.004.Full Text Link to Item
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Lopes, Renato D., Hwanhee Hong, Ralf E. Harskamp, Deepak L. Bhatt, Roxana Mehran, Christopher P. Cannon, Christopher B. Granger, et al. “Safety and Efficacy of Antithrombotic Strategies in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Network Meta-analysis of Randomized Controlled Trials.” Jama Cardiol 4, no. 8 (August 1, 2019): 747–55. https://doi.org/10.1001/jamacardio.2019.1880.Full Text Link to Item
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Guimarães, Patricia O., Renato D. Lopes, John H. Alexander, Laine Thomas, Anne S. Hellkamp, Ziad Hijazi, Elaine M. Hylek, et al. “International normalized ratio control and subsequent clinical outcomes in patients with atrial fibrillation using warfarin.” J Thromb Thrombolysis 48, no. 1 (July 2019): 27–34. https://doi.org/10.1007/s11239-019-01858-1.Full Text Link to Item
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Harskamp, Ralf E., John H. Alexander, and Renato D. Lopes. “Navigating the treacherous waters of antithrombotic therapies in patients with atrial fibrillation and coronary artery disease: Lessons from AUGUSTUS.” Eur J Intern Med 65 (July 2019): 4–5. https://doi.org/10.1016/j.ejim.2019.05.018.Full Text Link to Item
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Hohnloser, Stefan H., Marat Fudim, John H. Alexander, Daniel M. Wojdyla, Justin A. Ezekowitz, Michael Hanna, Dan Atar, et al. “Efficacy and Safety of Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Extremes in Body Weight.” Circulation 139, no. 20 (May 14, 2019): 2292–2300. https://doi.org/10.1161/CIRCULATIONAHA.118.037955.Full Text Link to Item
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Guimarães, Patricia O., Sean D. Pokorney, Renato D. Lopes, Daniel M. Wojdyla, Bernard J. Gersh, Anna Giczewska, Anthony Carnicelli, et al. “Efficacy and safety of apixaban vs warfarin in patients with atrial fibrillation and prior bioprosthetic valve replacement or valve repair: Insights from the ARISTOTLE trial.” Clin Cardiol 42, no. 5 (May 2019): 568–71. https://doi.org/10.1002/clc.23178.Full Text Link to Item
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Washam, Jeffrey B., Stefan H. Hohnloser, Renato D. Lopes, Daniel M. Wojdyla, Dragos Vinereanu, John H. Alexander, Bernard J. Gersh, et al. “Interacting medication use and the treatment effects of apixaban versus warfarin: results from the ARISTOTLE Trial.” J Thromb Thrombolysis 47, no. 3 (April 2019): 345–52. https://doi.org/10.1007/s11239-019-01823-y.Full Text Link to Item
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Ranney, David N., Judson B. Williams, Hillary Mulder, Daniel Wojdyla, Morgan L. Cox, C Michael Gibson, Michael J. Mack, Mani A. Daneshmand, John H. Alexander, and Renato D. Lopes. “Comparison of Outcomes and Frequency of Graft Failure With Use of Free Versus In Situ Internal Mammary Artery Bypass Conduits (from the PREVENT IV Trial).” Am J Cardiol 123, no. 4 (February 15, 2019): 571–75. https://doi.org/10.1016/j.amjcard.2018.11.029.Full Text Link to Item
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Fanaroff, Alexander C., Robert Clare, Karen S. Pieper, Kenneth W. Mahaffey, Chiara Melloni, Jennifer B. Green, John H. Alexander, et al. “Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9259 Deaths in 9 Trials.” Circulation 139, no. 7 (February 12, 2019): 863–73. https://doi.org/10.1161/CIRCULATIONAHA.118.037202.Full Text Link to Item
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Christersson, Christina, Lars Wallentin, Ulrika Andersson, John H. Alexander, Marco Alings, Raffaele De Caterina, Bernard J. Gersh, et al. “Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation.” Heart 105, no. 3 (February 2019): 235–42. https://doi.org/10.1136/heartjnl-2018-313351.Full Text Open Access Copy Link to Item
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Alexander, Karen P., Marc A. Brouwer, Hillary Mulder, Dragos Vinereanu, Renato D. Lopes, Marco Proietti, Sana M. Al-Khatib, et al. “Outcomes of apixaban versus warfarin in patients with atrial fibrillation and multi-morbidity: Insights from the ARISTOTLE trial.” Am Heart J 208 (February 2019): 123–31. https://doi.org/10.1016/j.ahj.2018.09.017.Full Text Link to Item
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Gibson, C Michael, Mathieu Kerneis, Megan K. Yee, Yazan Daaboul, Serge Korjian, Ali Poyan Mehr, Pierluigi Tricoci, et al. “The CSL112-2001 trial: Safety and tolerability of multiple doses of CSL112 (apolipoprotein A-I [human]), an intravenous formulation of plasma-derived apolipoprotein A-I, among subjects with moderate renal impairment after acute myocardial infarction.” Am Heart J 208 (February 2019): 81–90. https://doi.org/10.1016/j.ahj.2018.11.008.Full Text Link to Item
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Alexander, John H. “Antithrombotic Therapy Following CABG: For the Patient, Not the Bypass Graft.” J Am Coll Cardiol 73, no. 2 (January 22, 2019): 131–33. https://doi.org/10.1016/j.jacc.2018.10.049.Full Text Link to Item
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McGuire, Darren K., John H. Alexander, Odd Erik Johansen, Vlado Perkovic, Julio Rosenstock, Mark E. Cooper, Christoph Wanner, et al. “Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA.” Circulation 139, no. 3 (January 15, 2019): 351–61. https://doi.org/10.1161/CIRCULATIONAHA.118.038352.Full Text Link to Item
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Rosenstock, Julio, Vlado Perkovic, Odd Erik Johansen, Mark E. Cooper, Steven E. Kahn, Nikolaus Marx, John H. Alexander, et al. “Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial.” Jama 321, no. 1 (January 1, 2019): 69–79. https://doi.org/10.1001/jama.2018.18269.Full Text Link to Item
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Smith, Patrick J., Jeffrey N. Browndyke, Zachary A. Monge, Todd B. Harshbarger, Michael L. James, Jeffrey G. Gaca, John H. Alexander, et al. “Longitudinal Changes in Regional Cerebral Perfusion and Cognition After Cardiac Operation.” Ann Thorac Surg 107, no. 1 (January 2019): 112–18. https://doi.org/10.1016/j.athoracsur.2018.07.056.Full Text Open Access Copy Link to Item
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Schwartz, Gregory G., P Gabriel Steg, Michael Szarek, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Jay M. Edelberg, et al. “Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome.” N Engl J Med 379, no. 22 (November 29, 2018): 2097–2107. https://doi.org/10.1056/NEJMoa1801174.Full Text Link to Item
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Lopes, Renato D., Pedro G. M. de Barros E Silva, Isabella de Andrade Jesuíno, Eliana Vieira Santucci, Lilian Mazza Barbosa, Lucas Petri Damiani, Renato Hideo Nakagawa Santos, et al. “Timing of Loading Dose of Atorvastatin in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes: Insights From the SECURE-PCI Randomized Clinical Trial.” Jama Cardiol 3, no. 11 (November 1, 2018): 1113–18. https://doi.org/10.1001/jamacardio.2018.3408.Full Text Link to Item
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Minter, Stephanie, Alicia Armour, Amanda Tinnemore, Karen Strub, Anna Lisa Crowley, Gerald S. Bloomfield, John H. Alexander, et al. “Crowdsourcing consensus: proposal of a novel method for assessing accuracy in echocardiography interpretation.” Int J Cardiovasc Imaging 34, no. 11 (November 2018): 1725–30. https://doi.org/10.1007/s10554-018-1389-y.Full Text Link to Item
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Sharma, Abhinav, Ziad Hijazi, Ulrika Andersson, Sana M. Al-Khatib, Renato D. Lopes, John H. Alexander, Claes Held, et al. “Use of Biomarkers to Predict Specific Causes of Death in Patients With Atrial Fibrillation.” Circulation 138, no. 16 (October 16, 2018): 1666–76. https://doi.org/10.1161/CIRCULATIONAHA.118.034125.Full Text Link to Item
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Samad, Zainab, Linda K. Shaw, Matthew Phelan, Donald D. Glower, Mads Ersboll, John H. Toptine, John H. Alexander, et al. “Long-term outcomes of mitral regurgitation by type and severity.” Am Heart J 203 (September 2018): 39–48. https://doi.org/10.1016/j.ahj.2018.05.001.Full Text Link to Item
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Fanaroff, Alexander C., Jan Steffel, John H. Alexander, Gregory Y. H. Lip, Robert M. Califf, and Renato D. Lopes. “Stroke prevention in atrial fibrillation: re-defining 'real-world data' within the broader data universe.” Eur Heart J 39, no. 32 (August 21, 2018): 2932–41. https://doi.org/10.1093/eurheartj/ehy236.Full Text Link to Item
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Horowitz, John D., Raffaele De Caterina, Tamila Heresztyn, John H. Alexander, Ulrika Andersson, Renato D. Lopes, Philippe Gabriel Steg, et al. “Asymmetric and Symmetric Dimethylarginine Predict Outcomes in Patients With Atrial Fibrillation: An ARISTOTLE Substudy.” J Am Coll Cardiol 72, no. 7 (August 14, 2018): 721–33. https://doi.org/10.1016/j.jacc.2018.05.058.Full Text Link to Item
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Vinereanu, Dragos, Alice Wang, Hillary Mulder, Renato D. Lopes, Petr Jansky, Basil S. Lewis, Bernard J. Gersh, et al. “Outcomes in anticoagulated patients with atrial fibrillation and with mitral or aortic valve disease.” Heart 104, no. 15 (August 2018): 1292–99. https://doi.org/10.1136/heartjnl-2017-312272.Full Text Link to Item
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Inohara, Taku, Karen Pieper, Daniel M. Wojdyla, Manesh R. Patel, William Schuyler Jones, Pierluigi Tricoci, Kenneth W. Mahaffey, et al. “Incidence, timing, and type of first and recurrent ischemic events in patients with and without peripheral artery disease after an acute coronary syndrome.” Am Heart J 201 (July 2018): 25–32. https://doi.org/10.1016/j.ahj.2018.03.013.Full Text Link to Item
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Carson, Jeffrey L., Simon J. Stanworth, John H. Alexander, Nareg Roubinian, Dean A. Fergusson, Darrell J. Triulzi, Shaun G. Goodman, Sunil V. Rao, Carolyn Doree, and Paul C. Hebert. “Clinical trials evaluating red blood cell transfusion thresholds: An updated systematic review and with additional focus on patients with cardiovascular disease.” Am Heart J 200 (June 2018): 96–101. https://doi.org/10.1016/j.ahj.2018.04.007.Full Text Link to Item
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Lopes, Renato D., Amit N. Vora, Danny Liaw, Christopher B. Granger, Harald Darius, Shaun G. Goodman, Roxana Mehran, Stephan Windecker, and John H. Alexander. “An open-Label, 2 × 2 factorial, randomized controlled trial to evaluate the safety of apixaban vs. vitamin K antagonist and aspirin vs. placebo in patients with atrial fibrillation and acute coronary syndrome and/or percutaneous coronary intervention: Rationale and design of the AUGUSTUS trial.” Am Heart J 200 (June 2018): 17–23. https://doi.org/10.1016/j.ahj.2018.03.001.Full Text Link to Item
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Gurbel, Paul A., Udaya S. Tantry, Denise D’Andrea, Thomas Chung, John H. Alexander, Kevin P. Bliden, Samuel D. Wright, and Pierluigi Tricoci. “Evaluation of potential antiplatelet effects of CSL112 (Apolipoprotein A-I [Human]) in patients with atherosclerosis: results from a phase 2a study.” J Thromb Thrombolysis 45, no. 4 (May 2018): 469–76. https://doi.org/10.1007/s11239-018-1644-z.Full Text Link to Item
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Wang, Alice, Angie Wu, Daniel Wojdyla, Renato D. Lopes, L Kristin Newby, Mark F. Newman, Peter K. Smith, and John H. Alexander. “Dual antiplatelet therapy for perioperative myocardial infarction following CABG surgery.” Am Heart J 199 (May 2018): 150–55. https://doi.org/10.1016/j.ahj.2018.02.006.Full Text Link to Item
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Alexander, John H. “Ticagrelor Following Coronary Artery Bypass Grafting: For Better Vein Graft Patency or Better Patient Outcomes?” Jama 319, no. 16 (April 24, 2018): 1661–62. https://doi.org/10.1001/jama.2018.3793.Full Text Link to Item
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Berwanger, Otavio, Eliana Vieira Santucci, Pedro Gabriel Melo de Barros E Silva, Isabella de Andrade Jesuíno, Lucas Petri Damiani, Lilian Mazza Barbosa, Renato Hideo Nakagawa Santos, et al. “Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome: The SECURE-PCI Randomized Clinical Trial.” Jama 319, no. 13 (April 3, 2018): 1331–40. https://doi.org/10.1001/jama.2018.2444.Full Text Link to Item
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Berwanger, Otavio, Pedro G. M. de Barros E Silva, Frederico Toledo Campo Dall Orto, Pedro Beraldo de Andrade, Igor Ribeiro de Castro Bienert, Carlos Eduardo Bosso, José Mangione, et al. “Rationale and design of the Statins Evaluation in Coronary procedUres and REvascularization: The SECURE-PCI Trial.” Am Heart J 198 (April 2018): 129–34. https://doi.org/10.1016/j.ahj.2017.12.018.Full Text Link to Item
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Goto, Shinya, Peter Merrill, Lars Wallentin, Daniel M. Wojdyla, Michael Hanna, Alvaro Avezum, J Donald Easton, et al. “Antithrombotic therapy use and clinical outcomes following thrombo-embolic events in patients with atrial fibrillation: insights from ARISTOTLE.” Eur Heart J Cardiovasc Pharmacother 4, no. 2 (April 1, 2018): 75–81. https://doi.org/10.1093/ehjcvp/pvy002.Full Text Link to Item
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Gulack, Brian C., Katherine A. Kirkwood, Wei Shi, Peter K. Smith, John H. Alexander, Sandra G. Burks, Annetine C. Gelijns, et al. “Secondary surgical-site infection after coronary artery bypass grafting: A multi-institutional prospective cohort study.” The Journal of Thoracic and Cardiovascular Surgery 155, no. 4 (April 2018): 1555-1562.e1. https://doi.org/10.1016/j.jtcvs.2017.10.078.Full Text
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Rosenstock, Julio, Vlado Perkovic, John H. Alexander, Mark E. Cooper, Nikolaus Marx, Michael J. Pencina, Robert D. Toto, et al. “Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA®): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk.” Cardiovasc Diabetol 17, no. 1 (March 14, 2018): 39. https://doi.org/10.1186/s12933-018-0682-3.Full Text Open Access Copy Link to Item
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Lopes, Renato D., Roberto Rordorf, Gaetano M. De Ferrari, Sergio Leonardi, Laine Thomas, Daniel M. Wojdyla, Peter Ridefelt, et al. “Digoxin and Mortality in Patients With Atrial Fibrillation.” J Am Coll Cardiol 71, no. 10 (March 13, 2018): 1063–74. https://doi.org/10.1016/j.jacc.2017.12.060.Full Text Link to Item
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Sherwood, Matthew W., Renato D. Lopes, Jie Lena Sun, Danny Liaw, Robert A. Harrington, Lars Wallentin, Daniel T. Laskowitz, et al. “Apixaban following acute coronary syndromes in patients with prior stroke: Insights from the APPRAISE-2 trial.” Am Heart J 197 (March 2018): 1–8. https://doi.org/10.1016/j.ahj.2017.09.020.Full Text Link to Item
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Chiarito, Mauro, Davide Cao, Francesco Cannata, Cosmo Godino, Corrado Lodigiani, Giuseppe Ferrante, Renato D. Lopes, et al. “Direct Oral Anticoagulants in Addition to Antiplatelet Therapy for Secondary Prevention After Acute Coronary Syndromes: A Systematic Review and Meta-analysis.” Jama Cardiol 3, no. 3 (March 1, 2018): 234–41. https://doi.org/10.1001/jamacardio.2017.5306.Full Text Link to Item
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Kopin, David, W Schuyler Jones, Matthew W. Sherwood, Daniel M. Wojdyla, Lars Wallentin, Basil S. Lewis, Freek W. A. Verheugt, et al. “Percutaneous coronary intervention and antiplatelet therapy in patients with atrial fibrillation receiving apixaban or warfarin: Insights from the ARISTOTLE trial.” Am Heart J 197 (March 2018): 133–41. https://doi.org/10.1016/j.ahj.2017.11.005.Full Text Link to Item
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Rao, Meena P., Dragos Vinereanu, Daniel M. Wojdyla, John H. Alexander, Dan Atar, Elaine M. Hylek, Michael Hanna, et al. “Clinical Outcomes and History of Fall in Patients with Atrial Fibrillation Treated with Oral Anticoagulation: Insights From the ARISTOTLE Trial.” Am J Med 131, no. 3 (March 2018): 269-275.e2. https://doi.org/10.1016/j.amjmed.2017.10.036.Full Text Link to Item
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Hijazi, Ziad, Jonas Oldgren, Johan Lindbäck, John H. Alexander, Stuart J. Connolly, John W. Eikelboom, Michael D. Ezekowitz, et al. “A biomarker-based risk score to predict death in patients with atrial fibrillation: the ABC (age, biomarkers, clinical history) death risk score.” Eur Heart J 39, no. 6 (February 7, 2018): 477–85. https://doi.org/10.1093/eurheartj/ehx584.Full Text Link to Item
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Alexander, John H., Jacqueline Corrigan-Curay, and Mark McClellan. “The Clinical Trials Transformation Initiative: Looking back, looking forward.” Clin Trials 15, no. 1_suppl (February 2018): 3–4. https://doi.org/10.1177/1740774518755052.Full Text Link to Item
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Browndyke, Jeffrey N., Miles Berger, Patrick J. Smith, Todd B. Harshbarger, Zachary A. Monge, Viral Panchal, Tiffany L. Bisanar, et al. “Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults.” Hum Brain Mapp 39, no. 2 (February 2018): 985–1003. https://doi.org/10.1002/hbm.23898.Full Text Open Access Copy Link to Item
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Pol, Tymon, Claes Held, Johan Westerbergh, Johan Lindbäck, John H. Alexander, Marco Alings, Cetin Erol, et al. “Dyslipidemia and Risk of Cardiovascular Events in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Therapy: Insights From the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) Trial.” J Am Heart Assoc 7, no. 3 (February 1, 2018). https://doi.org/10.1161/JAHA.117.007444.Full Text Link to Item
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Sandhu, Roopinder K., Justin A. Ezekowitz, Ziad Hijazi, Johan Westerbergh, Julia Aulin, John H. Alexander, Christopher B. Granger, et al. “Obesity paradox on outcome in atrial fibrillation maintained even considering the prognostic influence of biomarkers: insights from the ARISTOTLE trial.” Open Heart 5, no. 2 (2018): e000908. https://doi.org/10.1136/openhrt-2018-000908.Full Text Link to Item
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Vinereanu, Dragos, Renato D. Lopes, Hillary Mulder, Bernard J. Gersh, Michael Hanna, Pedro G. M. de Barros E Silva, Dan Atar, et al. “Echocardiographic Risk Factors for Stroke and Outcomes in Patients With Atrial Fibrillation Anticoagulated With Apixaban or Warfarin.” Stroke 48, no. 12 (December 2017): 3266–73. https://doi.org/10.1161/STROKEAHA.117.017574.Full Text Link to Item
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Gaudino, Mario, John H. Alexander, Faisal G. Bakaeen, Karla Ballman, Fabio Barili, Antonio Maria Calafiore, Piroze Davierwala, et al. “Randomized comparison of the clinical outcome of single versus multiple arterial grafts: the ROMA trial-rationale and study protocol.” Eur J Cardiothorac Surg 52, no. 6 (December 1, 2017): 1031–40. https://doi.org/10.1093/ejcts/ezx358.Full Text Link to Item
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Dell’Anna, Antonio M., Gennaro De Pascale, and Massimo Antonelli. “Levosimendan in Cardiac Surgery.” N Engl J Med 377, no. 19 (November 9, 2017): 1899. https://doi.org/10.1056/NEJMc1711938.Full Text Link to Item
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Putzu, Alessandro, Sara Clivio, and Tiziano Cassina. “Levosimendan in Cardiac Surgery.” N Engl J Med 377, no. 19 (November 9, 2017): 1899–1900. https://doi.org/10.1056/NEJMc1711938.Full Text Link to Item
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Landoni, Giovanni, Vladimir V. Lomivorotov, and Rinaldo Bellomo. “Levosimendan in Cardiac Surgery.” N Engl J Med 377, no. 19 (November 9, 2017): 1900. https://doi.org/10.1056/NEJMc1711938.Full Text Link to Item
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Mehta, Rajendra H., John H. Alexander, and John H. LEVO-CTS Steering Committee Members and Trial Investigators. “Levosimendan in Cardiac Surgery.” N Engl J Med 377, no. 19 (November 9, 2017): 1900–1901. https://doi.org/10.1056/NEJMc1711938.Full Text Link to Item
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Brüggemann, Roger J., Frank L. van de Veerdonk, and Paul E. Verweij. “Itraconazole or Amphotericin B for Talaromycosis.” N Engl J Med 377, no. 14 (October 5, 2017): 1402–3. https://doi.org/10.1056/NEJMc1709123.Full Text Open Access Copy Link to Item
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Koshizaka, Masaya, Renato D. Lopes, L Kristin Newby, Robert M. Clare, Phillip J. Schulte, Pierluigi Tricoci, Kenneth W. Mahaffey, et al. “Obesity, Diabetes, and Acute Coronary Syndrome: Differences Between Asians and Whites.” Am J Med 130, no. 10 (October 2017): 1170–76. https://doi.org/10.1016/j.amjmed.2017.03.030.Full Text Link to Item
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Manning, Michael W., Mary Cooter, Joseph Mathew, John Alexander, Eric Peterson, T Bruce Ferguson, Renato Lopes, and Mihai Podgoreanu. “Angiotensin Receptor Blockade Improves Cardiac Surgical Outcomes in Patients With Metabolic Syndrome.” Ann Thorac Surg 104, no. 1 (July 2017): 98–105. https://doi.org/10.1016/j.athoracsur.2016.10.021.Full Text Link to Item
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Hijazi, Ziad, Bertil Lindahl, Jonas Oldgren, Ulrika Andersson, Johan Lindbäck, Christopher B. Granger, John H. Alexander, et al. “Repeated Measurements of Cardiac Biomarkers in Atrial Fibrillation and Validation of the ABC Stroke Score Over Time.” J Am Heart Assoc 6, no. 6 (June 23, 2017). https://doi.org/10.1161/JAHA.116.004851.Full Text Link to Item
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Newman, John H., Stuart Rich, Steven H. Abman, John H. Alexander, John Barnard, Gerald J. Beck, Raymond L. Benza, et al. “Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report.” Am J Respir Crit Care Med 195, no. 12 (June 15, 2017): 1661–70. https://doi.org/10.1164/rccm.201701-0150WS.Full Text Link to Item
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Ailawadi, Gorav, Helena L. Chang, Patrick T. O’Gara, Karen O’Sullivan, Y Joseph Woo, Joseph J. DeRose, Michael K. Parides, et al. “Pneumonia after cardiac surgery: Experience of the National Institutes of Health/Canadian Institutes of Health Research Cardiothoracic Surgical Trials Network.” J Thorac Cardiovasc Surg 153, no. 6 (June 2017): 1384-1391.e3. https://doi.org/10.1016/j.jtcvs.2016.12.055.Full Text Link to Item
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Guimarães, Patrícia O., Renato D. Lopes, Daniel M. Wojdyla, Azmil H. Abdul-Rahim, Stuart J. Connolly, Greg C. Flaker, Junyuan Wang, et al. “Effect of Apixaban on All-Cause Death in Patients with Atrial Fibrillation: a Meta-Analysis Based on Imputed Placebo Effect.” Cardiovasc Drugs Ther 31, no. 3 (June 2017): 295–301. https://doi.org/10.1007/s10557-017-6728-z.Full Text Link to Item
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Lopes, Renato D., Patrícia O. Guimarães, Bradley J. Kolls, Daniel M. Wojdyla, Cheryl D. Bushnell, Michael Hanna, J Donald Easton, et al. “Intracranial hemorrhage in patients with atrial fibrillation receiving anticoagulation therapy.” Blood 129, no. 22 (June 1, 2017): 2980–87. https://doi.org/10.1182/blood-2016-08-731638.Full Text Link to Item
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Mehta, Rajendra H., Jeffrey D. Leimberger, Sean van Diepen, James Meza, Alice Wang, Rachael Jankowich, Robert W. Harrison, et al. “Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery.” N Engl J Med 376, no. 21 (May 25, 2017): 2032–42. https://doi.org/10.1056/NEJMoa1616218.Full Text Link to Item
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Vora, Amit N., John H. Alexander, and Renato D. Lopes. “Dabigatran Compared With Rivaroxaban vs Warfarin.” Jama Intern Med 177, no. 5 (May 1, 2017): 742–43. https://doi.org/10.1001/jamainternmed.2017.0561.Full Text Link to Item
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Cowper, Patricia A., Shubin Sheng, Renato D. Lopes, Kevin J. Anstrom, Judith A. Stafford, Linda Davidson-Ray, Sana M. Al-Khatib, et al. “Economic Analysis of Apixaban Therapy for Patients With Atrial Fibrillation From a US Perspective: Results From the ARISTOTLE Randomized Clinical Trial.” Jama Cardiol 2, no. 5 (May 1, 2017): 525–34. https://doi.org/10.1001/jamacardio.2017.0065.Full Text Link to Item
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Diepen, Sean van, Peter D. Merrill, Michel Carrier, Jean-Claude Tardif, Mihai Podgoreanu, John H. Alexander, and Renato D. Lopes. “Association between CK-MB Area Under the Curve and Tranexamic Acid Utilization in Patients Undergoing Coronary Artery Bypass Surgery.” J Thromb Thrombolysis 43, no. 4 (May 2017): 446–53. https://doi.org/10.1007/s11239-017-1480-6.Full Text Open Access Copy Link to Item
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Hess, Connie N., Robert M. Clare, Megan L. Neely, Pierluigi Tricoci, Kenneth W. Mahaffey, Stefan K. James, John H. Alexander, et al. “Differential occurrence, profile, and impact of first recurrent cardiovascular events after an acute coronary syndrome.” Am Heart J 187 (May 2017): 194–203. https://doi.org/10.1016/j.ahj.2017.01.016.Full Text Link to Item
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Guimarães, Patrícia O., Renato D. Lopes, Susanna R. Stevens, André Zimerman, Lisa Wruck, Stefan K. James, Ghazala Haque, Roberto Rocha C. V. Giraldez, John H. Alexander, and Karen P. Alexander. “Reporting Clinical End Points and Safety Events in an Acute Coronary Syndrome Trial: Results With Integrated Collection.” J Am Heart Assoc 6, no. 4 (April 24, 2017). https://doi.org/10.1161/JAHA.117.005490.Full Text Link to Item
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Bahit, M Cecilia, Renato D. Lopes, Daniel M. Wojdyla, Claes Held, Michael Hanna, Dragos Vinereanu, Elaine M. Hylek, et al. “Non-major bleeding with apixaban versus warfarin in patients with atrial fibrillation.” Heart 103, no. 8 (April 2017): 623–28. https://doi.org/10.1136/heartjnl-2016-309901.Full Text Link to Item
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Souza Brito, Flávio de, Rajendra H. Mehta, Renato D. Lopes, Ralf E. Harskamp, B Daniel Lucas, Phillip J. Schulte, Jean-Claude Tardif, and John H. Alexander. “Nonsteroidal Anti-Inflammatory Drugs and Clinical Outcomes in Patients Undergoing Coronary Artery Bypass Surgery.” Am J Med 130, no. 4 (April 2017): 462–68. https://doi.org/10.1016/j.amjmed.2016.10.023.Full Text Link to Item
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Hess, Paul L., Jeff S. Healey, Christopher B. Granger, Stuart J. Connolly, Paul D. Ziegler, John H. Alexander, Peter R. Kowey, et al. “The Role of Cardiovascular Implantable Electronic Devices in the Detection and Treatment of Subclinical Atrial Fibrillation: A Review.” Jama Cardiol 2, no. 3 (March 1, 2017): 324–31. https://doi.org/10.1001/jamacardio.2016.5167.Full Text Link to Item
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Westenbrink, B Daan, Marco Alings, Christopher B. Granger, John H. Alexander, Renato D. Lopes, Elaine M. Hylek, Laine Thomas, et al. “Anemia is associated with bleeding and mortality, but not stroke, in patients with atrial fibrillation: Insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.” Am Heart J 185 (March 2017): 140–49. https://doi.org/10.1016/j.ahj.2016.12.008.Full Text Link to Item
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Hu, Peter T., Renato D. Lopes, Susanna R. Stevens, Lars Wallentin, Laine Thomas, John H. Alexander, Michael Hanna, et al. “Efficacy and Safety of Apixaban Compared With Warfarin in Patients With Atrial Fibrillation and Peripheral Artery Disease: Insights From the ARISTOTLE Trial.” J Am Heart Assoc 6, no. 1 (January 17, 2017). https://doi.org/10.1161/JAHA.116.004699.Full Text Link to Item
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Guimarães, Patrícia O., Daniel M. Wojdyla, John H. Alexander, Laine Thomas, Marco Alings, Greg C. Flaker, Sana M. Al-Khatib, et al. “Anticoagulation therapy and clinical outcomes in patients with recently diagnosed atrial fibrillation: Insights from the ARISTOTLE trial.” Int J Cardiol 227 (January 15, 2017): 443–49. https://doi.org/10.1016/j.ijcard.2016.11.014.Full Text Link to Item
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Browndyke, Jeffrey N., Miles Berger, Todd B. Harshbarger, Patrick J. Smith, William White, Tiffany L. Bisanar, John H. Alexander, et al. “Resting-State Functional Connectivity and Cognition After Major Cardiac Surgery in Older Adults without Preoperative Cognitive Impairment: Preliminary Findings.” J Am Geriatr Soc 65, no. 1 (January 2017): e6–12. https://doi.org/10.1111/jgs.14534.Full Text Open Access Copy Link to Item
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Hess, Connie N., Matthew T. Roe, C Michael Gibson, Robert J. Temple, Michael J. Pencina, Deborah A. Zarin, Kevin J. Anstrom, et al. “Independent data monitoring committees: preparing a path for the future.” Am Heart J 168, no. 2 (August 2014): 135-41.e1. https://doi.org/10.1016/j.ahj.2014.05.003.Full Text Link to Item
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Castleberry, Anthony W., Judson B. Williams, Mani A. Daneshmand, Emily Honeycutt, Linda K. Shaw, Zainab Samad, Renato D. Lopes, et al. “Surgical revascularization is associated with maximal survival in patients with ischemic mitral regurgitation: a 20-year experience.” Circulation 129, no. 24 (June 17, 2014): 2547–56. https://doi.org/10.1161/CIRCULATIONAHA.113.005223.Full Text Link to Item
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Mahaffey, Kenneth W., Daniel M. Wojdyla, Karen S. Pieper, Pierluigi Tricoci, John H. Alexander, A Michael Lincoff, Danielle M. Brennan, Deepak L. Bhatt, Lars Wallentin, and Robert A. Harrington. “Comparison of clinical trial outcome patterns in patients following acute coronary syndromes and in patients with chronic stable atherosclerosis.” Clin Cardiol 37, no. 6 (June 2014): 337–42. https://doi.org/10.1002/clc.22255.Full Text Link to Item
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Hylek, Elaine M., Claes Held, John H. Alexander, Renato D. Lopes, Raffaele De Caterina, Daniel M. Wojdyla, Kurt Huber, et al. “Major bleeding in patients with atrial fibrillation receiving apixaban or warfarin: The ARISTOTLE Trial (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation): Predictors, Characteristics, and Clinical Outcomes.” J Am Coll Cardiol 63, no. 20 (May 27, 2014): 2141–47. https://doi.org/10.1016/j.jacc.2014.02.549.Full Text Link to Item
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Harskamp, Ralf E., Akshay Bagai, Michael E. Halkos, Sunil V. Rao, William B. Bachinsky, Manesh R. Patel, Robbert J. de Winter, Eric D. Peterson, John H. Alexander, and Renato D. Lopes. “Clinical outcomes after hybrid coronary revascularization versus coronary artery bypass surgery: a meta-analysis of 1,190 patients.” Am Heart J 167, no. 4 (April 2014): 585–92. https://doi.org/10.1016/j.ahj.2014.01.006.Full Text Link to Item
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Nelson, James A., John P. Vavalle, Christopher H. May, Aijing Zhang, L Kristin Newby, Linda K. Shaw, Sana M. Al-Khatib, John H. Alexander, Christopher B. Granger, and Renato D. Lopes. “Warfarin use and long-term outcomes in patients with acute myocardial infarction and atrial fibrillation.” J Thromb Thrombolysis 37, no. 3 (April 2014): 331–37. https://doi.org/10.1007/s11239-013-0946-4.Full Text Link to Item
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Flaker, Greg, Renato D. Lopes, Sana M. Al-Khatib, Antonio G. Hermosillo, Stefan H. Hohnloser, Brian Tinga, Jun Zhu, et al. “Efficacy and safety of apixaban in patients after cardioversion for atrial fibrillation: insights from the ARISTOTLE Trial (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation).” J Am Coll Cardiol 63, no. 11 (March 25, 2014): 1082–87. https://doi.org/10.1016/j.jacc.2013.09.062.Full Text Link to Item
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Harskamp, Ralf E., John H. Alexander, Phillip J. Schulte, W Schuyler Jones, Judson B. Williams, Michael J. Mack, Eric D. Peterson, et al. “Impact of extracardiac vascular disease on vein graft failure and outcomes after coronary artery bypass surgery.” Ann Thorac Surg 97, no. 3 (March 2014): 824–30. https://doi.org/10.1016/j.athoracsur.2013.09.099.Full Text Link to Item
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Hijazi, Ziad, Agneta Siegbahn, Ulrika Andersson, Christopher B. Granger, John H. Alexander, Dan Atar, Bernard J. Gersh, et al. “High-sensitivity troponin I for risk assessment in patients with atrial fibrillation: insights from the Apixaban for Reduction in Stroke and other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.” Circulation 129, no. 6 (February 11, 2014): 625–34. https://doi.org/10.1161/CIRCULATIONAHA.113.006286.Full Text Link to Item
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Diepen, Sean van, Harmony R. Reynolds, Amanda Stebbins, Renato D. Lopes, Vladimír Džavík, Witold Ruzyllo, Alexander Geppert, et al. “Incidence and outcomes associated with early heart failure pharmacotherapy in patients with ongoing cardiogenic shock.” Crit Care Med 42, no. 2 (February 2014): 281–88. https://doi.org/10.1097/CCM.0b013e31829f6242.Full Text Link to Item
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Harskamp, Ralf E., Johannes O. Bonatti, David X. Zhao, John D. Puskas, Robbert J. de Winter, John H. Alexander, and Michael E. Halkos. “Standardizing definitions for hybrid coronary revascularization.” J Thorac Cardiovasc Surg 147, no. 2 (February 2014): 556–60. https://doi.org/10.1016/j.jtcvs.2013.10.019.Full Text Link to Item
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Wallentin, Lars, Renato D. Lopes, Michael Hanna, Laine Thomas, Anne Hellkamp, Sunil Nepal, Elaine M. Hylek, et al. “Response to letter regarding article, "Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation".” Circulation 129, no. 2 (January 14, 2014): e21–22. https://doi.org/10.1161/CIRCULATIONAHA.113.005709.Full Text Link to Item
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Alexander, John H., Renato D. Lopes, Laine Thomas, Marco Alings, Dan Atar, Philip Aylward, Shinya Goto, et al. “Apixaban vs. warfarin with concomitant aspirin in patients with atrial fibrillation: insights from the ARISTOTLE trial.” Eur Heart J 35, no. 4 (January 2014): 224–32. https://doi.org/10.1093/eurheartj/eht445.Full Text Link to Item
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Harskamp, R. E., J. H. Alexander, P. J. Schulte, W. S. Jones, J. B. Williams, M. J. Mack, E. D. Peterson, et al. “Impact of extracardiac vascular disease on vein graft failure and outcomes after coronary artery bypass surgery.” Annals of Thoracic Surgery 97, no. 3 (2014): 824–30.
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Bahit, Maria Cecilia, Renato D. Lopes, Daniel M. Wojdyla, Stefan H. Hohnloser, John H. Alexander, Basil S. Lewis, Philip E. Aylward, et al. “Apixaban in patients with atrial fibrillation and prior coronary artery disease: insights from the ARISTOTLE trial.” Int J Cardiol 170, no. 2 (December 10, 2013): 215–20. https://doi.org/10.1016/j.ijcard.2013.10.062.Full Text Link to Item
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Harrison, Robert W., Vic Hasselblad, Rajendra H. Mehta, Ricardo Levin, Robert A. Harrington, and John H. Alexander. “Effect of levosimendan on survival and adverse events after cardiac surgery: a meta-analysis.” J Cardiothorac Vasc Anesth 27, no. 6 (December 2013): 1224–32. https://doi.org/10.1053/j.jvca.2013.03.027.Full Text Link to Item
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Harskamp, Ralf E., Zhe Zheng, John H. Alexander, Judson B. Williams, Ying Xian, Michael E. Halkos, J Matthew Brennan, Robbert J. de Winter, Peter K. Smith, and Renato D. Lopes. “Status quo of hybrid coronary revascularization for multi-vessel coronary artery disease.” Ann Thorac Surg 96, no. 6 (December 2013): 2268–77. https://doi.org/10.1016/j.athoracsur.2013.07.093.Full Text Link to Item
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Vavalle, John P., Thomas J. Povsic, Laura H. Aberle, Steven L. Zelenkofske, Roxana Mehran, Jaroslaw D. Kasprzak, Christoph Bode, et al. “Safety of very early sheath removal in patients treated with REG1 for acute coronary syndromes: insights from the RADAR trial.” J Invasive Cardiol 25, no. 11 (November 2013): 593–99.Link to Item
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Williams, Judson B., Renato D. Lopes, Gail E. Hafley, T Bruce Ferguson, Michael J. Mack, C Michael Gibson, Robert A. Harrington, et al. “Relationship between postoperative clopidogrel use and subsequent angiographic and clinical outcomes following coronary artery bypass grafting.” J Thromb Thrombolysis 36, no. 4 (November 2013): 384–93. https://doi.org/10.1007/s11239-013-0904-1.Full Text Link to Item
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Garcia, David A., Lars Wallentin, Renato D. Lopes, Laine Thomas, John H. Alexander, Elaine M. Hylek, Jack Ansell, et al. “Apixaban versus warfarin in patients with atrial fibrillation according to prior warfarin use: results from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial.” Am Heart J 166, no. 3 (September 2013): 549–58. https://doi.org/10.1016/j.ahj.2013.05.016.Full Text Link to Item
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Alexander, John H., Elliott Levy, Jack Lawrence, Michael Hanna, Anthony P. Waclawski, Junyuan Wang, Robert M. Califf, Lars Wallentin, and Christopher B. Granger. “Documentation of study medication dispensing in a prospective large randomized clinical trial: experiences from the ARISTOTLE Trial.” Am Heart J 166, no. 3 (September 2013): 559–65. https://doi.org/10.1016/j.ahj.2013.05.025.Full Text Link to Item
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Steinberg, Benjamin A., Vic Hasselblad, Brett D. Atwater, Tristram D. Bahnson, Jeffrey B. Washam, John H. Alexander, James P. Daubert, and Jonathan P. Piccini. “Dabigatran for periprocedural anticoagulation following radiofrequency ablation for atrial fibrillation: a meta-analysis of observational studies.” J Interv Card Electrophysiol 37, no. 3 (September 2013): 213–21. https://doi.org/10.1007/s10840-013-9813-7.Full Text Link to Item
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Al-Khatib, Sana M., Laine Thomas, Lars Wallentin, Renato D. Lopes, Bernard Gersh, David Garcia, Justin Ezekowitz, et al. “Outcomes of apixaban vs. warfarin by type and duration of atrial fibrillation: results from the ARISTOTLE trial.” Eur Heart J 34, no. 31 (August 2013): 2464–71. https://doi.org/10.1093/eurheartj/eht135.Full Text Link to Item
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Povsic, Thomas J., John P. Vavalle, Laura H. Aberle, Jaroslaw D. Kasprzak, Mauricio G. Cohen, Roxana Mehran, Christoph Bode, et al. “A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial.” Eur Heart J 34, no. 31 (August 2013): 2481–89. https://doi.org/10.1093/eurheartj/ehs232.Full Text Link to Item
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Alexander, John H. “Off-pump or on-pump coronary-artery bypass grafting.” N Engl J Med 369, no. 2 (July 11, 2013): 197. https://doi.org/10.1056/NEJMc1306329.Full Text Link to Item
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Diegeler, Anno, Wilko Reents, and Michael Zacher. “Off-pump or on-pump coronary-artery bypass grafting.” N Engl J Med 369, no. 2 (July 11, 2013): 196–97. https://doi.org/10.1056/NEJMc1306329.Full Text Link to Item
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Emmert, Maximilian Y., and Sacha P. Salzberg. “Off-pump or on-pump coronary-artery bypass grafting.” N Engl J Med 369, no. 2 (July 11, 2013): 194–95. https://doi.org/10.1056/NEJMc1306329.Full Text Link to Item
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Sun, Xiaoning, and Chunsheng Wang. “Off-pump or on-pump coronary-artery bypass grafting.” N Engl J Med 369, no. 2 (July 11, 2013): 194. https://doi.org/10.1056/NEJMc1306329.Full Text Link to Item
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Saeed, Giovanni, Michael Möller, and Rainer Gradaus. “Off-pump or on-pump coronary-artery bypass grafting.” N Engl J Med 369, no. 2 (July 11, 2013): 195. https://doi.org/10.1056/NEJMc1306329.Full Text Link to Item
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Sanfilippo, Filippo, Cristina Santonocito, and Marc O. Maybauer. “Off-pump or on-pump coronary-artery bypass grafting.” N Engl J Med 369, no. 2 (July 11, 2013): 194. https://doi.org/10.1056/NEJMc1306329.Full Text Link to Item
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Souza Brito, Flavio de, Renato D. Lopes, and John H. Alexander. “The safety and efficacy of apixaban : where do we stand in 2013?” Expert Opin Drug Saf 12, no. 4 (July 2013): 559–67. https://doi.org/10.1517/14740338.2013.799663.Full Text Link to Item
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Wallentin, Lars, Renato D. Lopes, Michael Hanna, Laine Thomas, Anne Hellkamp, Sunil Nepal, Elaine M. Hylek, et al. “Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation.” Circulation 127, no. 22 (June 4, 2013): 2166–76. https://doi.org/10.1161/CIRCULATIONAHA.112.142158.Full Text Link to Item
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Alexander, John H., and Eric D. Peterson. “Surgery. Translating trials to clinical practice in cardiac surgery.” Nat Rev Cardiol 10, no. 6 (June 2013): 306–7. https://doi.org/10.1038/nrcardio.2013.67.Full Text Link to Item
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Oldgren, Jonas, Lars Wallentin, John H. Alexander, Stefan James, Birgitta Jönelid, Gabriel Steg, and Johan Sundström. “New oral anticoagulants in addition to single or dual antiplatelet therapy after an acute coronary syndrome: a systematic review and meta-analysis.” Eur Heart J 34, no. 22 (June 2013): 1670–80. https://doi.org/10.1093/eurheartj/eht049.Full Text Link to Item
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Harskamp, Ralf E., Judson B. Williams, Ronald C. Hill, Robbert J. de Winter, John H. Alexander, and Renato D. Lopes. “Saphenous vein graft failure and clinical outcomes: toward a surrogate end point in patients following coronary artery bypass surgery?” Am Heart J 165, no. 5 (May 2013): 639–43. https://doi.org/10.1016/j.ahj.2013.01.019.Full Text Link to Item
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McMurray, John J. V., Justin A. Ezekowitz, Basil S. Lewis, Bernard J. Gersh, Sean van Diepen, John Amerena, Jozef Bartunek, et al. “Left ventricular systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with atrial fibrillation: insights from the ARISTOTLE trial.” Circ Heart Fail 6, no. 3 (May 2013): 451–60. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000143.Full Text Link to Item
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Harskamp, Ralf E., Renato D. Lopes, Clinton E. Baisden, Robbert J. de Winter, and John H. Alexander. “Saphenous vein graft failure after coronary artery bypass surgery: pathophysiology, management, and future directions.” Ann Surg 257, no. 5 (May 2013): 824–33. https://doi.org/10.1097/SLA.0b013e318288c38d.Full Text Link to Item
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Subherwal, Sumeet, E Magnus Ohman, Kenneth W. Mahaffey, Sunil V. Rao, John H. Alexander, Tracy Y. Wang, Karen P. Alexander, Vic Hasselblad, and Matthew T. Roe. “Incorporation of bleeding as an element of the composite end point in clinical trials of antithrombotic therapies in patients with non-ST-segment elevation acute coronary syndrome: validity, pitfalls, and future approaches.” Am Heart J 165, no. 5 (May 2013): 644-654.e1. https://doi.org/10.1016/j.ahj.2012.11.012.Full Text Link to Item
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Alexander, John H. “Clinical-outcome trials in cardiac surgery--have we primed the pump?” N Engl J Med 368, no. 13 (March 28, 2013): 1247–48. https://doi.org/10.1056/NEJMe1302717.Full Text Link to Item
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Williams, Eric S., Vivian P. Thompson, Karen E. Chiswell, John H. Alexander, Harvey D. White, E Magnus Ohman, and Sana M. Al-Khatib. “Rate versus rhythm control and outcomes in patients with atrial fibrillation and chronic kidney disease: data from the GUSTO-III Trial.” Cardiol J 20, no. 4 (2013): 439–46. https://doi.org/10.5603/CJ.2013.0104.Full Text Link to Item
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Lopes, Renato D., Sana M. Al-Khatib, Lars Wallentin, Hongqiu Yang, Jack Ansell, M Cecilia Bahit, Raffaele De Caterina, et al. “Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: a secondary analysis of a randomised controlled trial.” Lancet 380, no. 9855 (November 17, 2012): 1749–58. https://doi.org/10.1016/S0140-6736(12)60986-6.Full Text Link to Item
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Hess, Connie N., Richard C. Becker, John H. Alexander, and Renato D. Lopes. “Antithrombotic therapy in heparin-induced thrombocytopenia: guidelines translated for the clinician.” J Thromb Thrombolysis 34, no. 4 (November 2012): 552–61. https://doi.org/10.1007/s11239-012-0785-8.Full Text Link to Item
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Hohnloser, Stefan H., Ziad Hijazi, Laine Thomas, John H. Alexander, John Amerena, Michael Hanna, Matyas Keltai, et al. “Efficacy of apixaban when compared with warfarin in relation to renal function in patients with atrial fibrillation: insights from the ARISTOTLE trial.” Eur Heart J 33, no. 22 (November 2012): 2821–30. https://doi.org/10.1093/eurheartj/ehs274.Full Text Link to Item
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Roe, Matthew T., Paul W. Armstrong, Keith A. A. Fox, Harvey D. White, Dorairaj Prabhakaran, Shaun G. Goodman, Jan H. Cornel, et al. “Prasugrel versus clopidogrel for acute coronary syndromes without revascularization.” N Engl J Med 367, no. 14 (October 4, 2012): 1297–1309. https://doi.org/10.1056/NEJMoa1205512.Full Text Link to Item
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Gutierrez, A., P. Tricoci, and J. H. P. Alexander. “Pentasaccharide Derivatives,” October 3, 2012, 128–49. https://doi.org/10.1002/9781118410875.ch9.Full Text
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Hess, Connie N., Samuel Broderick, Jonathan P. Piccini, Karen P. Alexander, L Kristin Newby, Linda K. Shaw, Kenneth W. Mahaffey, et al. “Antithrombotic therapy for atrial fibrillation and coronary artery disease in older patients.” Am Heart J 164, no. 4 (October 2012): 607–15. https://doi.org/10.1016/j.ahj.2012.07.004.Full Text Link to Item
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Lopes, Renato D., Judson B. Williams, Rajendra H. Mehta, Eric M. Reyes, Gail E. Hafley, Keith B. Allen, Michael J. Mack, et al. “Edifoligide and long-term outcomes after coronary artery bypass grafting: PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) 5-year results.” Am Heart J 164, no. 3 (September 2012): 379-386.e1. https://doi.org/10.1016/j.ahj.2012.05.019.Full Text Link to Item
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Williams, Judson B., Eric D. Peterson, J Matthew Brennan, Art Sedrakyan, Dale Tavris, John H. Alexander, Renato D. Lopes, et al. “Association between endoscopic vs open vein-graft harvesting and mortality, wound complications, and cardiovascular events in patients undergoing CABG surgery.” Jama 308, no. 5 (August 1, 2012): 475–84. https://doi.org/10.1001/jama.2012.8363.Full Text Link to Item
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Vavalle, J. P., C. P. Rusconi, S. Zelenkofske, W. A. Wargin, J. H. Alexander, and R. C. Becker. “A phase 1 ascending dose study of a subcutaneously administered factor IXa inhibitor and its active control agent.” J Thromb Haemost 10, no. 7 (July 2012): 1303–11. https://doi.org/10.1111/j.1538-7836.2012.04742.x.Full Text Link to Item
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Easton, J Donald, Renato D. Lopes, M Cecilia Bahit, Daniel M. Wojdyla, Christopher B. Granger, Lars Wallentin, Marco Alings, et al. “Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial.” Lancet Neurol 11, no. 6 (June 2012): 503–11. https://doi.org/10.1016/S1474-4422(12)70092-3.Full Text Link to Item
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Wiggins, Newton B., Christopher B. Granger, and John H. Alexander. “Novel oral anticoagulants after acute coronary syndromes.” Cardiovasc Drugs Ther 26, no. 3 (June 2012): 265–71. https://doi.org/10.1007/s10557-012-6386-0.Full Text Link to Item
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Herrmann, Howard C., Zachary M. Gertz, Frank E. Silvestry, Susan E. Wiegers, Y Joseph Woo, James Hermiller, Douglas Segar, et al. “Effects of atrial fibrillation on treatment of mitral regurgitation in the EVEREST II (Endovascular Valve Edge-to-Edge Repair Study) randomized trial.” J Am Coll Cardiol 59, no. 14 (April 3, 2012): 1312–19. https://doi.org/10.1016/j.jacc.2011.12.023.Full Text Link to Item
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Vavalle, J. P., and J. H. Alexander. “Authors' reply to "the not so 'ideal' body weight-based dosing of Integrilin in obesity".” American Heart Journal 163, no. 4 (April 1, 2012). https://doi.org/10.1016/j.ahj.2012.01.033.Full Text
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Lopes, Renato D., Rajendra H. Mehta, Gail E. Hafley, Judson B. Williams, Michael J. Mack, Eric D. Peterson, Keith B. Allen, et al. “Relationship between vein graft failure and subsequent clinical outcomes after coronary artery bypass surgery.” Circulation 125, no. 6 (February 14, 2012): 749–56. https://doi.org/10.1161/CIRCULATIONAHA.111.040311.Full Text Link to Item
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Al-Khatib, Sana M., John H. Alexander, Renato D. Lopes, Kenneth W. Mahaffey, Manesh R. Patel, and Christopher B. Granger. “Promise of factor Xa inhibition in atrial fibrillation.” Curr Cardiol Rep 14, no. 1 (February 2012): 70–78. https://doi.org/10.1007/s11886-011-0230-1.Full Text Link to Item
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Mehta, Rajendra H., Amanda S. Stebbins, Renato D. Lopes, Robert M. Califf, Karen S. Pieper, Paul W. Armstrong, Frans Van de Werf, et al. “Comparison of incidence of bleeding and mortality of men versus women with ST-elevation myocardial infarction treated with fibrinolysis.” Am J Cardiol 109, no. 3 (February 1, 2012): 320–26. https://doi.org/10.1016/j.amjcard.2011.09.012.Full Text Link to Item
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Koshizaka, Masaya, Jennifer B. Green, and John H. Alexander. “Glycemic management in diabetes and the associated cardiovascular risk: are we helping or hurting our patients?” Circ J 76, no. 7 (2012): 1572–80. https://doi.org/10.1253/circj.cj-12-0428.Full Text Link to Item
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Smith, Peter K., Robert E. Michler, Y Joseph Woo, John H. Alexander, John D. Puskas, Michael K. Parides, Rebecca T. Hahn, et al. “Design, rationale, and initiation of the Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial: a report from the Cardiothoracic Surgical Trials Network.” J Thorac Cardiovasc Surg 143, no. 1 (January 2012): 111-117.e1. https://doi.org/10.1016/j.jtcvs.2011.05.006.Full Text Link to Item
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Vavalle, John P., Susanna R. Stevens, Nancy Hassinger, Mauricio G. Cohen, Anita Arnold, David E. Kandzari, Frank V. Aguirre, Daniel D. Gretler, and John H. Alexander. “The kinetics of integrilin limited by obesity: a multicenter randomized pharmacokinetic and pharmacodynamic clinical trial.” Am Heart J 162, no. 6 (December 2011): 996–1002. https://doi.org/10.1016/j.ahj.2011.09.014.Full Text Link to Item
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Fauchier, Laurent, and Nicolas Clementy. “Apixaban after acute coronary syndrome.” N Engl J Med 365, no. 19 (November 10, 2011): 1844. https://doi.org/10.1056/NEJMc1111422.Full Text Link to Item
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Povsic, Thomas J., Christopher M. O’Connor, Timothy Henry, Andrew Taussig, Dean J. Kereiakes, F David Fortuin, Alan Niederman, et al. “A double-blind, randomized, controlled, multicenter study to assess the safety and cardiovascular effects of skeletal myoblast implantation by catheter delivery in patients with chronic heart failure after myocardial infarction.” Am Heart J 162, no. 4 (October 2011): 654-662.e1. https://doi.org/10.1016/j.ahj.2011.07.020.Full Text Link to Item
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Povsic, Thomas J., William A. Wargin, John H. Alexander, Joshua Krasnow, Merill Krolick, Mauricio G. Cohen, Roxana Mehran, et al. “Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy.” Eur Heart J 32, no. 19 (October 2011): 2412–19. https://doi.org/10.1093/eurheartj/ehr179.Full Text Link to Item
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Granger, Christopher B., John H. Alexander, John J. V. McMurray, Renato D. Lopes, Elaine M. Hylek, Michael Hanna, Hussein R. Al-Khalidi, et al. “Apixaban versus warfarin in patients with atrial fibrillation.” N Engl J Med 365, no. 11 (September 15, 2011): 981–92. https://doi.org/10.1056/NEJMoa1107039.Full Text Link to Item
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Lobato, Robert L., William D. White, Joseph P. Mathew, Mark F. Newman, Peter K. Smith, Charles B. McCants, John H. Alexander, Mihai V. Podgoreanu, and Mihai V. Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team. “Thrombomodulin gene variants are associated with increased mortality after coronary artery bypass surgery in replicated analyses.” Circulation 124, no. 11 Suppl (September 13, 2011): S143–48. https://doi.org/10.1161/CIRCULATIONAHA.110.008334.Full Text Link to Item
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Alexander, John H., Renato D. Lopes, Stefan James, Rakhi Kilaru, Yaohua He, Puneet Mohan, Deepak L. Bhatt, et al. “Apixaban with antiplatelet therapy after acute coronary syndrome.” N Engl J Med 365, no. 8 (August 25, 2011): 699–708. https://doi.org/10.1056/NEJMoa1105819.Full Text Link to Item
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Becker, Richard C., Hongqiu Yang, Yuchen Barrett, Puneet Mohan, Jessie Wang, Lars Wallentin, and John H. Alexander. “Chromogenic laboratory assays to measure the factor Xa-inhibiting properties of apixaban--an oral, direct and selective factor Xa inhibitor.” J Thromb Thrombolysis 32, no. 2 (August 2011): 183–87. https://doi.org/10.1007/s11239-011-0591-8.Full Text Link to Item
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Lopes, Renato D., Richard C. Becker, John H. Alexander, Paul W. Armstrong, Robert M. Califf, Mark Y. Chan, Mark Crowther, et al. “Highlights from the III International Symposium of Thrombosis and Anticoagulation (ISTA), October 14-16, 2010, São Paulo, Brazil.” J Thromb Thrombolysis 32, no. 2 (August 2011): 242–66. https://doi.org/10.1007/s11239-011-0592-7.Full Text Link to Item
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Mehta, Rajendra H., T Bruce Ferguson, Renato D. Lopes, Gail E. Hafley, Michael J. Mack, Nicholas T. Kouchoukos, C Michael Gibson, et al. “Saphenous vein grafts with multiple versus single distal targets in patients undergoing coronary artery bypass surgery: one-year graft failure and five-year outcomes from the Project of Ex-Vivo Vein Graft Engineering via Transfection (PREVENT) IV trial.” Circulation 124, no. 3 (July 19, 2011): 280–88. https://doi.org/10.1161/CIRCULATIONAHA.110.991299.Full Text Link to Item
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Povsic, T. J., M. G. Cohen, M. Y. Chan, S. L. Zelenkofske, W. A. Wargin, R. A. Harrington, J. H. Alexander, C. P. Rusconi, and R. C. Becker. “Dose selection for a direct and selective factor IXa inhibitor and its complementary reversal agent: translating pharmacokinetic and pharmacodynamic properties of the REG1 system to clinical trial design.” J Thromb Thrombolysis 32, no. 1 (July 2011): 21–31. https://doi.org/10.1007/s11239-011-0588-3.Full Text Link to Item
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Leiria, Tiago L. L., Renato D. Lopes, Judson B. Williams, Jason N. Katz, Renato A. K. Kalil, and John H. Alexander. “Antithrombotic therapies in patients with prosthetic heart valves: guidelines translated for the clinician.” J Thromb Thrombolysis 31, no. 4 (May 2011): 514–22. https://doi.org/10.1007/s11239-011-0574-9.Full Text Link to Item
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Domanski, Michael J., Kenneth Mahaffey, Vic Hasselblad, Sorin J. Brener, Peter K. Smith, Graham Hillis, Milo Engoren, et al. “Association of myocardial enzyme elevation and survival following coronary artery bypass graft surgery.” Jama 305, no. 6 (February 9, 2011): 585–91. https://doi.org/10.1001/jama.2011.99.Full Text Link to Item
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Povsic, Thomas J., Mauricio G. Cohen, Roxana Mehran, Christopher E. Buller, Christoph Bode, Jan H. Cornel, JarosÅ‚aw D. Kasprzak, et al. “A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: design and rationale of the RADAR Phase IIb trial.” Am Heart J 161, no. 2 (February 2011): 261-268.e1-2. https://doi.org/10.1016/j.ahj.2010.10.022.Full Text Link to Item
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Alexander, J. “SY06-5 Apixaban for the Prevention of Thromboembolic Events in Patients with Atrial Fibrillation: Primary Results of the ARISTOTLE Trial.” Journal of Arrhythmia 27 (January 1, 2011). https://doi.org/10.4020/jhrs.27.SY06_5.Full Text
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Mehta, Rajendra H., Amanda Stebbins, Renato D. Lopes, Sunil V. Rao, Eric R. Bates, Karen S. Pieper, Paul W. Armstrong, et al. “Race, Bleeding, and Outcomes in STEMI Patients Treated with Fibrinolytic Therapy.” Am J Med 124, no. 1 (January 2011): 48–57. https://doi.org/10.1016/j.amjmed.2010.07.028.Full Text Link to Item
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Piccini, Jonathan P., Phillip J. Schulte, Karen S. Pieper, Rajendra H. Mehta, Harvey D. White, Frans Van de Werf, Diego Ardissino, et al. “Antiarrhythmic drug therapy for sustained ventricular arrhythmias complicating acute myocardial infarction.” Crit Care Med 39, no. 1 (January 2011): 78–83. https://doi.org/10.1097/CCM.0b013e3181fd6ad7.Full Text Link to Item
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Saito, Shigeru, Ross Prpic, Jeffery J. Popma, John Alexander, Mitchell W. Krucoff, and Mitchell W. ENDEAVOR Japan Investigators. “The clinical evaluation of the Endeavor zotarolimus-eluting coronary stent in Japanese patients with de novo native coronary artery lesions: primary results and 3-year follow-up of the Endeavor Japan study.” Cardiovasc Revasc Med 12, no. 5 (2011): 273–79. https://doi.org/10.1016/j.carrev.2010.12.007.Full Text Link to Item
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Stashenko, Gregg, Renato D. Lopes, David Garcia, John H. Alexander, and Victor F. Tapson. “Prophylaxis for venous thromboembolism: guidelines translated for the clinician.” J Thromb Thrombolysis 31, no. 1 (January 2011): 122–32. https://doi.org/10.1007/s11239-010-0522-0.Full Text Link to Item
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Becker, Richard C., John H. Alexander, L Kristin Newby, Hongqiu Yang, Yuchen Barrett, Puneet Mohan, Jessie Wang, Robert A. Harrington, and Lars C. Wallentin. “Effect of apixaban, an oral and direct factor Xa inhibitor, on coagulation activity biomarkers following acute coronary syndrome.” Thromb Haemost 104, no. 5 (November 2010): 976–83. https://doi.org/10.1160/TH10-04-0247.Full Text Link to Item
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Cohen, Mauricio G., Drew A. Purdy, Joseph S. Rossi, Liliana R. Grinfeld, Shelley K. Myles, Laura H. Aberle, Adam B. Greenbaum, et al. “First clinical application of an actively reversible direct factor IXa inhibitor as an anticoagulation strategy in patients undergoing percutaneous coronary intervention.” Circulation 122, no. 6 (August 10, 2010): 614–22. https://doi.org/10.1161/CIRCULATIONAHA.109.927756.Full Text Link to Item
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Frederich, Robert, John H. Alexander, Fred T. Fiedorek, Mark Donovan, Niklas Berglind, Susan Harris, Roland Chen, Robert Wolf, and Kenneth W. Mahaffey. “A systematic assessment of cardiovascular outcomes in the saxagliptin drug development program for type 2 diabetes.” Postgrad Med 122, no. 3 (May 2010): 16–27. https://doi.org/10.3810/pgm.2010.05.2138.Full Text Link to Item
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Gharacholou, S Michael, Renato D. Lopes, Jeffrey B. Washam, L Kristin Newby, Stefan K. James, and John H. Alexander. “Antithrombotic therapy in acute coronary syndromes: guidelines translated for the clinician.” J Thromb Thrombolysis 29, no. 4 (May 2010): 516–28. https://doi.org/10.1007/s11239-009-0437-9.Full Text Link to Item
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Lopes, Renato D., David Garcia, Richard C. Becker, Christopher B. Granger, L Kristin Newby, John H. Alexander, E Marc Jolicoeur, et al. “Highlights from the II International Symposium of Thrombosis and Anticoagulation (ISTA), October 22-23, 2009, São Paulo, Brazil.” J Thromb Thrombolysis 29, no. 4 (May 2010): 395–408. https://doi.org/10.1007/s11239-010-0454-8.Full Text Link to Item
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Rao, Sunil V., Chiara Melloni, Shelley Myles-Dimauro, Samuel Broderick, Andrzej S. Kosinski, Neal S. Kleiman, Vladimír Dzavík, et al. “Evaluation of a new heparin agent in percutaneous coronary intervention: results of the phase 2 evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) Trial.” Circulation 121, no. 15 (April 20, 2010): 1713–21. https://doi.org/10.1161/CIRCULATIONAHA.109.913277.Full Text Link to Item
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Krishnan, Anandi, Renato D. Lopes, John H. Alexander, Richard C. Becker, and Larry B. Goldstein. “Antithrombotic therapy for ischemic stroke: guidelines translated for the clinician.” J Thromb Thrombolysis 29, no. 3 (April 2010): 368–77. https://doi.org/10.1007/s11239-010-0439-7.Full Text Link to Item
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Lopes, Renato D., John H. Alexander, Sana M. Al-Khatib, Jack Ansell, Raphael Diaz, J Donald Easton, Bernard J. Gersh, et al. “Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: design and rationale.” Am Heart J 159, no. 3 (March 2010): 331–39. https://doi.org/10.1016/j.ahj.2009.07.035.Full Text Link to Item
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Lopes, Renato D., John H. Alexander, and T Bruce Ferguson. “Endoscopic versus Open Vein-Graft Harvesting REPLY.” New England Journal of Medicine 361, no. 19 (November 5, 2009): 1909–10.Link to Item
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Al-Khatib, Sana M., Gail Hafley, Robert A. Harrington, Michael J. Mack, Thomas Bruce Ferguson, Eric D. Peterson, Robert M. Califf, Nicholas T. Kouchoukos, and John H. Alexander. “Patterns of management of atrial fibrillation complicating coronary artery bypass grafting: Results from the PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT-IV) Trial.” Am Heart J 158, no. 5 (November 2009): 792–98. https://doi.org/10.1016/j.ahj.2009.09.003.Full Text Link to Item
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Houman Fekrazad, M., Renato D. Lopes, Gregg J. Stashenko, John H. Alexander, and David Garcia. “Treatment of venous thromboembolism: guidelines translated for the clinician.” J Thromb Thrombolysis 28, no. 3 (October 2009): 270–75. https://doi.org/10.1007/s11239-009-0374-7.Full Text Link to Item
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Katz, Jason N., Amanda L. Stebbins, John H. Alexander, Harmony R. Reynolds, Karen S. Pieper, Witold Ruzyllo, Karl Werdan, et al. “Predictors of 30-day mortality in patients with refractory cardiogenic shock following acute myocardial infarction despite a patent infarct artery.” Am Heart J 158, no. 4 (October 2009): 680–87. https://doi.org/10.1016/j.ahj.2009.08.005.Full Text Link to Item
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Lopes, Renato D., Gail E. Hafley, Keith B. Allen, T Bruce Ferguson, Eric D. Peterson, Robert A. Harrington, Rajendra H. Mehta, et al. “Endoscopic versus open vein-graft harvesting in coronary-artery bypass surgery.” N Engl J Med 361, no. 3 (July 16, 2009): 235–44. https://doi.org/10.1056/NEJMoa0900708.Full Text Link to Item
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Kraai, Erik P., Renato D. Lopes, John H. Alexander, and David Garcia. “Perioperative management of anticoagulation: guidelines translated for the clinician.” J Thromb Thrombolysis 28, no. 1 (July 2009): 16–22. https://doi.org/10.1007/s11239-009-0313-7.Full Text Link to Item
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APPRAISE Steering Committee and Investigators, Lars, John H. Alexander, Richard C. Becker, Deepak L. Bhatt, Frank Cools, Filippo Crea, Mikael Dellborg, et al. “Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial.” Circulation 119, no. 22 (June 9, 2009): 2877–85. https://doi.org/10.1161/CIRCULATIONAHA.108.832139.Full Text Link to Item
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Turer, Aslan T., Kenneth W. Mahaffey, Emily Honeycutt, Robert H. Tuttle, Linda K. Shaw, Michael H. Sketch, Peter K. Smith, Robert M. Califf, and John H. Alexander. “Influence of body mass index on the efficacy of revascularization in patients with coronary artery disease.” J Thorac Cardiovasc Surg 137, no. 6 (June 2009): 1468–74. https://doi.org/10.1016/j.jtcvs.2008.11.047.Full Text Link to Item
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Alexander, John H. “The current state of antiplatelet therapy in acute coronary syndromes: the data and the real world.” Cleve Clin J Med 76 Suppl 1 (April 2009): S16–23. https://doi.org/10.3949/ccjm.76.s1.03.Full Text Link to Item
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Bhatt, Deepak L., Kandice Kottke-Marchant, John H. Alexander, W Frank Peacock, and Marc S. Sabatine. “Platelet response in practice: Applying new insights and tools for testing and treatment.” Cleve Clin J Med 76 Suppl 1 (April 2009): S24–32. https://doi.org/10.3949/ccjm.76.s1.04.Full Text Link to Item
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Lopes, Renato D., Jonathan P. Piccini, Elaine M. Hylek, Christopher B. Granger, and John H. Alexander. “Antithrombotic therapy in atrial fibrillation: guidelines translated for the clinician.” J Thromb Thrombolysis 26, no. 3 (December 2008): 167–74. https://doi.org/10.1007/s11239-008-0272-4.Full Text Link to Item
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Mehta, Rajendra H., Gail E. Hafley, C Michael Gibson, Robert A. Harrington, Eric D. Peterson, Michael J. Mack, Nicholas T. Kouchoukos, et al. “Influence of preoperative renal dysfunction on one-year bypass graft patency and two-year outcomes in patients undergoing coronary artery bypass surgery.” J Thorac Cardiovasc Surg 136, no. 5 (November 2008): 1149–55. https://doi.org/10.1016/j.jtcvs.2008.02.085.Full Text Link to Item
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Alexander, J. H., S. J. Ellis, and J. C. Tardif. “In reply.” Jama 300, no. 9 (September 3, 2008): 1021–22. https://doi.org/10.1001/jama.300.9.1021-b.Full Text
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Yau, James M., John H. Alexander, Gail Hafley, Kenneth W. Mahaffey, Michael J. Mack, Nicholas Kouchoukos, Abhinav Goyal, et al. “Impact of perioperative myocardial infarction on angiographic and clinical outcomes following coronary artery bypass grafting (from PRoject of Ex-vivo Vein graft ENgineering via Transfection [PREVENT] IV).” Am J Cardiol 102, no. 5 (September 1, 2008): 546–51. https://doi.org/10.1016/j.amjcard.2008.04.069.Full Text Link to Item
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Chan, Mark Y., Mauricio G. Cohen, Christopher K. Dyke, Shelley K. Myles, Laura G. Aberle, Min Lin, James Walder, et al. “Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease.” Circulation 117, no. 22 (June 3, 2008): 2865–74. https://doi.org/10.1161/CIRCULATIONAHA.107.745687.Full Text Link to Item
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Chan, M. Y., C. P. Rusconi, J. H. Alexander, R. M. Tonkens, R. A. Harrington, and R. C. Becker. “A randomized, repeat-dose, pharmacodynamic and safety study of an antidote-controlled factor IXa inhibitor.” J Thromb Haemost 6, no. 5 (May 2008): 789–96. https://doi.org/10.1111/j.1538-7836.2008.02932.x.Full Text Link to Item
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MEND-CABG II Investigators, Jean-Claude, John H. Alexander, Robert W. Emery, Michel Carrier, Stephen J. Ellis, Rajendra H. Mehta, Vic Hasselblad, et al. “Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial.” Jama 299, no. 15 (April 16, 2008): 1777–87. https://doi.org/10.1001/jama.299.15.joc80027.Full Text Link to Item
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Mehta, Rajendra H., John H. Alexander, Robert Emery, Stephen J. Ellis, Vic Hasselblad, Ahmad Khalil, Michel Carrier, Robert A. Harrington, Jean-Claude Tardif, and Jean-Claude MEND-CABG II Investigators. “A randomized, double-blind, placebo-controlled, multicenter study to evaluate the cardioprotective effects of MC-1 in patients undergoing high-risk coronary artery bypass graft surgery: MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery Trial (MEND-CABG) II--study design and rationale.” Am Heart J 155, no. 4 (April 2008): 600–608. https://doi.org/10.1016/j.ahj.2008.01.002.Full Text Link to Item
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Magee, Mitchell J., John H. Alexander, Gail Hafley, T Bruce Ferguson, C Michael Gibson, Robert A. Harrington, Eric D. Peterson, et al. “Coronary artery bypass graft failure after on-pump and off-pump coronary artery bypass: findings from PREVENT IV.” Ann Thorac Surg 85, no. 2 (February 2008): 494–99. https://doi.org/10.1016/j.athoracsur.2007.10.008.Full Text Link to Item
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Olenchock, Stephen A., Dimitri Karmpaliotis, William J. Gibson, Sabina A. Murphy, Matthew C. Southard, Lauren Ciaglo, Jacqueline Buros, et al. “Impact of saphenous vein graft radiographic markers on clinical events and angiographic parameters.” Ann Thorac Surg 85, no. 2 (February 2008): 520–24. https://doi.org/10.1016/j.athoracsur.2007.10.061.Full Text Link to Item
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Harrington, R. A., J. H. Alexander, J. S. Hochman, H. R. Reynolds, V. Dzavik, and F. J. Van De Werf. “Tilarginine in patients with acute myocardial infarction and cardiogenic shock - In reply [7].” Jama 298, no. 9 (September 5, 2007): 972–73. https://doi.org/10.1001/jama.298.9.972.Full Text
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Cohen, Marc, Deepak L. Bhatt, John H. Alexander, Gilles Montalescot, Christoph Bode, Timothy Henry, Jean-Francois Tamby, et al. “Randomized, double-blind, dose-ranging study of otamixaban, a novel, parenteral, short-acting direct factor Xa inhibitor, in percutaneous coronary intervention: the SEPIA-PCI trial.” Circulation 115, no. 20 (May 22, 2007): 2642–51. https://doi.org/10.1161/CIRCULATIONAHA.106.653428.Full Text Link to Item
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Dzavík, Vladimir, Gad Cotter, Harmony R. Reynolds, John H. Alexander, Krishnan Ramanathan, Amanda L. Stebbins, David Hathaway, et al. “Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study.” Eur Heart J 28, no. 9 (May 2007): 1109–16. https://doi.org/10.1093/eurheartj/ehm075.Full Text Link to Item
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TRIUMPH Investigators, Judith S., John H. Alexander, Harmony R. Reynolds, Amanda L. Stebbins, Vladimir Dzavik, Robert A. Harrington, Frans Van de Werf, and Judith S. Hochman. “Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial.” Jama 297, no. 15 (April 18, 2007): 1657–66. https://doi.org/10.1001/jama.297.15.joc70035.Full Text Link to Item
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Goyal, Abhinav, John H. Alexander, Gail E. Hafley, Stacy H. Graham, Rajendra H. Mehta, Michael J. Mack, Randall K. Wolf, et al. “Outcomes associated with the use of secondary prevention medications after coronary artery bypass graft surgery.” Ann Thorac Surg 83, no. 3 (March 2007): 993–1001. https://doi.org/10.1016/j.athoracsur.2006.10.046.Full Text Link to Item
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Mahaffey, Kenneth W., Matthew T. Roe, Rakhi Kilaru, John H. Alexander, Frans Van de Werf, Robert M. Califf, Maarten L. Simoons, Eric J. Topol, and Robert A. Harrington. “Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials.” Eur Heart J 28, no. 4 (February 2007): 425–32. https://doi.org/10.1093/eurheartj/ehl483.Full Text Link to Item
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Dyke, Christopher K., Steven R. Steinhubl, Neal S. Kleiman, Richard O. Cannon, Laura G. Aberle, Min Lin, Shelley K. Myles, et al. “First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity.” Circulation 114, no. 23 (December 5, 2006): 2490–97. https://doi.org/10.1161/CIRCULATIONAHA.106.668434.Full Text Link to Item
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Madsen, Lene H., Geir Christensen, Terje Lund, Victor L. Serebruany, Chris B. Granger, Ingvild Hoen, Zanina Grieg, et al. “Time course of degradation of cardiac troponin I in patients with acute ST-elevation myocardial infarction: the ASSENT-2 troponin substudy.” Circ Res 99, no. 10 (November 10, 2006): 1141–47. https://doi.org/10.1161/01.RES.0000249531.23654.e1.Full Text Link to Item
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Alexander, John H., and Robert A. Harrington. “Advances in antithrombotic therapy in acute myocardial infarction: the ExTRACT-TIMI 25 and OASIS-6 Trials.” Curr Cardiol Rep 8, no. 4 (July 2006): 279–81. https://doi.org/10.1007/s11886-006-0059-1.Full Text Link to Item
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Alexander, J. H., R. A. Harrington, T. B. Ferguson, E. D. Peterson, C. M. Gibson, and N. T. Kouchoukos. “In reply [4].” Jama 295, no. 13 (April 5, 2006): 1514–15. https://doi.org/10.1001/jama.295.13.1514-b.Full Text
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Becker, Richard C., John H. Alexander, Christopher Dyke, Yao Huang, Henock Saint-Jacques, Vic Hasselblad, Robert A. Harrington, Edwin G. Bovill, and Edwin G. XaNADU-1B Investigators. “Effect of the novel direct factor Xa inhibitor DX-9065a on thrombin generation and inhibition among patients with stable atherosclerotic coronary artery disease.” Thromb Res 117, no. 4 (2006): 439–46. https://doi.org/10.1016/j.thromres.2005.03.017.Full Text Link to Item
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Galla, John M., Kenneth W. Mahaffey, Shelly K. Sapp, John H. Alexander, Matthew T. Roe, E Magnus Ohman, Christopher B. Granger, et al. “Elevated creatine kinase-MB with normal creatine kinase predicts worse outcomes in patients with acute coronary syndromes: results from 4 large clinical trials.” Am Heart J 151, no. 1 (January 2006): 16–24. https://doi.org/10.1016/j.ahj.2005.01.045.Full Text Link to Item
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Alexander, John H., Gail Hafley, Robert A. Harrington, Eric D. Peterson, T Bruce Ferguson, Todd J. Lorenz, Abhinav Goyal, et al. “Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial.” Jama 294, no. 19 (November 16, 2005): 2446–54. https://doi.org/10.1001/jama.294.19.2446.Full Text Link to Item
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Halabi, Abdul R., John H. Alexander, Linda K. Shaw, Todd J. Lorenz, Lawrence Liao, David F. Kong, Carmelo A. Milano, Robert A. Harrington, and Peter K. Smith. “Relation of early saphenous vein graft failure to outcomes following coronary artery bypass surgery.” Am J Cardiol 96, no. 9 (November 1, 2005): 1254–59. https://doi.org/10.1016/j.amjcard.2005.06.067.Full Text Link to Item
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Alexander, John H., T Bruce Ferguson, Diane M. Joseph, Michael J. Mack, Randall K. Wolf, C Michael Gibson, Daniel Gennevois, et al. “The PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) trial: study rationale, design, and baseline patient characteristics.” Am Heart J 150, no. 4 (October 2005): 643–49. https://doi.org/10.1016/j.ahj.2005.05.021.Full Text Link to Item
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Mahaffey, Kenneth W., Matthew T. Roe, Rakhi Kilaru, John K. French, John H. Alexander, Lisa G. Berdan, Frans Van De Werf, et al. “Characterization of myocardial infarction as an end point in two large trials of acute coronary syndromes.” Am J Cardiol 95, no. 12 (June 15, 2005): 1404–8. https://doi.org/10.1016/j.amjcard.2005.02.005.Full Text Link to Item
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Mehta, Rajendra H., Robert M. Califf, Jyotsna Garg, Karen S. Pieper, John H. Alexander, David J. Moliterno, Frans Van de Werf, et al. “Association of height with outcomes in patients with acute myocardial infarction receiving reperfusion therapy.” Am J Cardiol 95, no. 11 (June 1, 2005): 1371–75. https://doi.org/10.1016/j.amjcard.2005.01.087.Full Text Link to Item
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Mehta, Rajendra H., John H. Alexander, Frans Van de Werf, Paul W. Armstrong, Karen S. Pieper, Jyotsna Garg, Robert M. Califf, and Christopher B. Granger. “Relationship of incorrect dosing of fibrinolytic therapy and clinical outcomes.” Jama 293, no. 14 (April 13, 2005): 1746–50. https://doi.org/10.1001/jama.293.14.1746.Full Text Link to Item
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Meine, Trip J., Sana M. Al-Khatib, John H. Alexander, Christopher B. Granger, Harvey D. White, Rakhi Kilaru, Kathryn Williams, E Magnus Ohman, Eric Topol, and Robert M. Califf. “Incidence, predictors, and outcomes of high-degree atrioventricular block complicating acute myocardial infarction treated with thrombolytic therapy.” Am Heart J 149, no. 4 (April 2005): 670–74. https://doi.org/10.1016/j.ahj.2004.07.035.Full Text Link to Item
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Alexander, J. H., H. Yang, R. C. Becker, K. Kodama, S. Goodman, C. K. Dyke, N. S. Kleiman, et al. “First experience with direct, selective factor Xa inhibition in patients with non-ST-elevation acute coronary syndromes: results of the XaNADU-ACS Trial.” J Thromb Haemost 3, no. 3 (March 2005): 439–47. https://doi.org/10.1111/j.1538-7836.2004.01081.x.Full Text Link to Item
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Borges-Neto, Salvador, Linda K. Shaw, Robert H. Tuttle, John H. Alexander, William T. Smith, Marianna Chambless, R Edward Coleman, Robert A. Harrington, and Robert M. Califf. “Incremental prognostic power of single-photon emission computed tomographic myocardial perfusion imaging in patients with known or suspected coronary artery disease.” Am J Cardiol 95, no. 2 (January 15, 2005): 182–88. https://doi.org/10.1016/j.amjcard.2004.09.004.Full Text Link to Item
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Alexander, John H., and Kanwar P. Singh. “Inhibition of Factor Xa : a potential target for the development of new anticoagulants.” Am J Cardiovasc Drugs 5, no. 5 (2005): 279–90. https://doi.org/10.2165/00129784-200505050-00001.Full Text Link to Item
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Becker, Richard C., John Alexander, Christopher K. Dyke, and Robert A. Harrington. “Development of DX-9065a, a novel direct factor Xa antagonist, in cardiovascular disease.” Thromb Haemost 92, no. 6 (December 2004): 1182–93. https://doi.org/10.1160/TH04-05-0289.Full Text Link to Item
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Becker, Richard C., John Alexander, You Fu Li, Edwin Bovill, Frederick A. Spencer, Thomas L. Robertson, Satoshi Kunitada, Christopher K. Dyke, and Robert A. Harrington. “Combined coagulation phase-directed factor Xa inhibition with heparin compounds and DX-9065a - a direct and selective antagonist.” Thromb Haemost 92, no. 6 (December 2004): 1229–31.Link to Item
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Becker, Richard C., John H. Alexander, Youfu Li, Thomas Robertson, Satoshi Kunitada, Frederick A. Spencer, Hongqiu Yang, and Robert A. Harrington. “Vascular endothelial tissue factor pathway inhibitor kinetics in culture following exposure to DX-9065a--a selective and direct factor Xa inhibitor.” J Thromb Thrombolysis 18, no. 3 (December 2004): 193–97. https://doi.org/10.1007/s11239-005-0345-6.Full Text Link to Item
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Weston, Patrick, John H. Alexander, Manesh R. Patel, Charles Maynard, Lawrence Crawford, and Galen S. Wagner. “Hand-held echocardiographic examination of patients with symptoms of acute coronary syndromes in the emergency department: the 30-day outcome associated with normal left ventricular wall motion.” Am Heart J 148, no. 6 (December 2004): 1096–1101. https://doi.org/10.1016/j.ahj.2004.05.026.Full Text Link to Item
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Bethel, M Angelyn, John Alexander, Jim Lane, Christina Barkauskas, and Mark N. Feinglos. “Diabetes on a cardiovascular ward: adherence to current recommendations.” South Med J 97, no. 11 (November 2004): 1031–37. https://doi.org/10.1097/01.SMJ.0000140853.71806.31.Full Text Link to Item
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Curtis, Jeptha P., John H. Alexander, Yao Huang, Lars Wallentin, Freek W. A. Verheugt, Paul W. Armstrong, Harlan M. Krumholz, et al. “Efficacy and safety of two unfractionated heparin dosing strategies with tenecteplase in acute myocardial infarction (results from Assessment of the Safety and Efficacy of a New Thrombolytic Regimens 2 and 3).” Am J Cardiol 94, no. 3 (August 1, 2004): 279–83. https://doi.org/10.1016/j.amjcard.2004.04.019.Full Text Link to Item
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Waters, Richard E., Kanwar P. Singh, Matthew T. Roe, Mat Lotfi, Michael H. Sketch, Kenneth W. Mahaffey, L Kristin Newby, et al. “Rationale and strategies for implementing community-based transfer protocols for primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction.” J Am Coll Cardiol 43, no. 12 (June 16, 2004): 2153–59. https://doi.org/10.1016/j.jacc.2003.12.057.Full Text Link to Item
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Sinnaeve, Peter R., John H. Alexander, Kris Bogaerts, Ann Belmans, Lars Wallentin, Paul Armstrong, Jennifer A. A. Adgey, et al. “Efficacy of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: one-year follow-up results of the Assessment of the Safety of a New Thrombolytic-3 (ASSENT-3) randomized trial in acute myocardial infarction.” Am Heart J 147, no. 6 (June 2004): 993–98. https://doi.org/10.1016/j.ahj.2003.12.028.Full Text Link to Item
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Alexander, John H., Eric D. Peterson, Anita Y. Chen, Tina M. Harding, David B. Adams, and Joseph A. Kisslo. “Feasibility of point-of-care echocardiography by internal medicine house staff.” Am Heart J 147, no. 3 (March 2004): 476–81. https://doi.org/10.1016/j.ahj.2003.10.010.Full Text Link to Item
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Alexander, J. H., C. K. Dyke, H. Yang, R. C. Becker, V. Hasselblad, L. A. Zillman, N. S. Kleiman, et al. “Initial experience with factor-Xa inhibition in percutaneous coronary intervention: the XaNADU-PCI Pilot.” J Thromb Haemost 2, no. 2 (February 2004): 234–41. https://doi.org/10.1111/j.1538-7933.2004.00594.x.Full Text Link to Item
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Alexander, John H. “Clinical trials in Japan and the United States.” Am Heart J 147, no. 2 (February 2004): 200–201. https://doi.org/10.1016/j.ahj.2003.11.004.Full Text Link to Item
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Roe, M. T., K. W. Mahaffey, R. Kilaru, J. H. Alexander, K. M. Akkerhuis, M. L. Simoons, R. A. Harrington, et al. “Creatine kinase-MB elevation after percutaneous coronary intervention predicts adverse outcomes in patients with acute coronary syndromes.” Eur Heart J 25, no. 4 (February 2004): 313–21. https://doi.org/10.1016/j.ehj.2003.12.009.Full Text Link to Item
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Rebeiz, Abdallah G., Matthew T. Roe, John H. Alexander, Kenneth W. Mahaffey, Christopher B. Granger, Eric D. Peterson, Robert M. Califf, and Robert A. Harrington. “Integrating antithrombin and antiplatelet therapies with early invasive management for non-ST-segment elevation acute coronary syndromes.” Am J Med 116, no. 2 (January 15, 2004): 119–29. https://doi.org/10.1016/j.amjmed.2003.09.028.Full Text Link to Item
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Alexander, John H., Robert A. Harrington, Manju Bhapkar, Kenneth W. Mahaffey, A Michael Lincoff, E Magnus Ohman, Peter Klootwijk, et al. “Prognostic importance of new small Q waves following non-ST-elevation acute coronary syndromes.” Am J Med 115, no. 8 (December 1, 2003): 613–19. https://doi.org/10.1016/j.amjmed.2003.08.007.Full Text Link to Item
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Alexander, John H., and Manesh R. Patel. “Screening for structural heart disease: time to stop listening and start looking.” Am Heart J 146, no. 4 (October 2003): 570–71. https://doi.org/10.1016/S0002-8703(03)00397-1.Full Text Link to Item
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Sinnaeve, Peter, John Alexander, Ann Belmans, Kris Bogaerts, Anatoli Langer, Rafaël Diaz, Diego Ardissino, et al. “One-year follow-up of the ASSENT-2 trial: a double-blind, randomized comparison of single-bolus tenecteplase and front-loaded alteplase in 16,949 patients with ST-elevation acute myocardial infarction.” Am Heart J 146, no. 1 (July 2003): 27–32. https://doi.org/10.1016/S0002-8703(03)00117-0.Full Text Link to Item
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Serebruany, Victor L., Alex I. Malinin, Kevin P. Callahan, Azan Binbrek, Frans Van De Werf, John H. Alexander, Christopher B. Granger, Paul A. Gurbel, and Paul A. Assessment of the Safety and Efficacy of a New Thrombolytic Agent platelet substudy. “Effect of tenecteplase versus alteplase on platelets during the first 3 hours of treatment for acute myocardial infarction: the Assessment of the Safety and Efficacy of a New Thrombolytic Agent (ASSENT-2) platelet substudy.” Am Heart J 145, no. 4 (April 2003): 636–42. https://doi.org/10.1067/mhj.2003.210.Full Text Link to Item
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Akkerhuis, K Martijn, John H. Alexander, Barbara E. Tardiff, Eric Boersma, Robert A. Harrington, A Michael Lincoff, and Maarten L. Simoons. “Minor myocardial damage and prognosis: are spontaneous and percutaneous coronary intervention-related events different?” Circulation 105, no. 5 (February 5, 2002): 554–56. https://doi.org/10.1161/hc0502.104278.Full Text Link to Item
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Angeja, B. G., J. H. Alexander, R. Chin, X. Li, H. V. Barron, P. W. Armstrong, C. B. Granger, F. Van de Werf, and C. M. Gibson. “Safety of the weight-adjusted dosing regimen of tenecteplase in the ASSENT-Trial.” Am J Cardiol 88, no. 11 (December 1, 2001): 1240–45. https://doi.org/10.1016/s0002-9149(01)02084-7.Full Text Link to Item
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Callahan, K. P., A. I. Malinin, P. A. Gurbel, J. H. Alexander, C. B. Granger, D. Atar, and V. L. Serebruany. “Platelets and thrombolysis: Cooperation or contrariety?” Heartdrug 1, no. 5 (December 1, 2001): 281–90. https://doi.org/10.1159/000048975.Full Text
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Daniels, S. R. “Short-term trials and long-term effects.” Science 293, no. 5539 (September 28, 2001): 2392–94. https://doi.org/10.1126/science.293.5539.2392.Full Text Link to Item
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Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 Investigators, Raymond J. “Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction.” Lancet 358, no. 9282 (August 25, 2001): 605–13. https://doi.org/10.1016/S0140-6736(01)05775-0.Full Text Link to Item
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Al-Khatib, S. M., R. M. Califf, V. Hasselblad, J. H. Alexander, D. C. McCrory, and J. Sugarman. “Medicine. Placebo-controls in short-term clinical trials of hypertension.” Science 292, no. 5524 (June 15, 2001): 2013–15. https://doi.org/10.1126/science.1057783.Full Text Link to Item
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Callahan, K. P., A. I. Malinin, P. A. Gurbel, J. H. Alexander, C. B. Granger, and V. L. Serebruany. “Platelet function and fibrinolytic agents: two sides of a coin?” Cardiology 95, no. 2 (2001): 55–60. https://doi.org/10.1159/000047346.Full Text Link to Item
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Alexander, J. H., R. A. Sparapani, K. W. Mahaffey, J. W. Deckers, L. K. Newby, E. M. Ohman, R. Corbalán, et al. “Association between minor elevations of creatine kinase-MB level and mortality in patients with acute coronary syndromes without ST-segment elevation. PURSUIT Steering Committee. Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy.” Jama 283, no. 3 (January 19, 2000): 347–53. https://doi.org/10.1001/jama.283.3.347.Full Text Link to Item
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McGuire, D. K., M. P. Hudson, M. A. East, C. K. Dyke, W. J. Cantor, J. Battle, M. C. Bahit, S. M. Al-Khatib, and J. H. Alexander. “Highlights from the American Heart Association 72nd Scientific Sessions: November 6 to 10, 1999.” American Heart Journal 139, no. 2 (January 1, 2000): 359–70. https://doi.org/10.1016/S0002-8703(00)90247-3.Full Text
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Patel, M., S. S. Han, K. Vaux, J. Saalfeld, and J. H. Alexander. “A protocol of early spiral computed tomography for the detection of stones in patients with renal colic has reduced the time to diagnosis and overall management costs.” Aust N Z J Surg 70, no. 1 (January 2000): 39–42. https://doi.org/10.1046/j.1440-1622.2000.01740.x.Full Text Link to Item
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Alexander, J. H., S. Al-Khatib, W. Cantor, A. B. Greenbaum, M. P. Hudson, D. F. Kong, and M. Shah. “Highlights from the American College of Cardiology 48th Annual Scientific Sessions: March 7 to 10, 1999.” Am Heart J 138, no. 1 Pt 1 (July 1999): 175–90. https://doi.org/10.1016/s0002-8703(99)90000-5.Full Text Link to Item
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Pertusi, R. M., K. S. Godwin, J. K. House, J. A. Knebl, J. H. Alexander, B. R. Rubin, and M. D. Forman. “Gastropathy induced by nonsteroidal anti-inflammatory drugs: prescribing patterns among geriatric practitioners.” J Am Osteopath Assoc 99, no. 6 (June 1999): 305–10. https://doi.org/10.7556/jaoa.1999.99.6.305.Full Text Link to Item
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Sadowski, Z. P., J. H. Alexander, B. Skrabucha, A. Dyduszynski, J. Kuch, E. Nartowicz, G. Swiatecka, D. F. Kong, and C. B. Granger. “Multicenter randomized trial and a systematic overview of lidocaine in acute myocardial infarction.” Am Heart J 137, no. 5 (May 1999): 792–98. https://doi.org/10.1016/s0002-8703(99)70401-1.Full Text Link to Item
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Alexander, J. H., C. B. Granger, Z. Sadowski, P. E. Aylward, H. D. White, T. D. Thompson, R. M. Califf, and E. J. Topol. “Prophylactic lidocaine use in acute myocardial infarction: incidence and outcomes from two international trials. The GUSTO-I and GUSTO-IIb Investigators.” Am Heart J 137, no. 5 (May 1999): 799–805. https://doi.org/10.1016/s0002-8703(99)70402-3.Full Text Link to Item
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Eachempati, S. R., C. Young, J. Alexander, F. D. Cirisano, G. C. Rodriguez, and R. L. Reed. “The clinical use of an esophageal Doppler monitor for hemodynamic monitoring in sepsis.” J Clin Monit Comput 15, no. 3–4 (May 1999): 223–25. https://doi.org/10.1023/a:1009963124127.Full Text Link to Item
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Alexander, J. H., R. A. Harrington, R. H. Tuttle, L. G. Berdan, A. M. Lincoff, J. W. Deckers, M. L. Simoons, et al. “Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes. PURSUIT Investigators. Platelet IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy.” Am J Cardiol 83, no. 8 (April 15, 1999): 1147–51. https://doi.org/10.1016/s0002-9149(99)00049-1.Full Text Link to Item
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Alexander, J. H., D. F. Kong, and W. J. Cantor. “Highlights from the 71st American Heart Association Scientific Sessions: November 8 to 11, 1998.” Am Heart J 137, no. 3 (March 1999): 555–74. https://doi.org/10.1016/s0002-8703(99)70506-5.Full Text Link to Item
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Alexander, J. H., and R. A. Harrington. “Recent antiplatelet drug trials in the acute coronary syndromes. Clinical interpretation of PRISM, PRISM-PLUS, PARAGON A and PURSUIT.” Drugs 56, no. 6 (December 1998): 965–76. https://doi.org/10.2165/00003495-199856060-00002.Full Text Link to Item
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“Combining thrombolysis with the platelet glycoprotein IIb/IIIa inhibitor lamifiban: results of the Platelet Aggregation Receptor Antagonist Dose Investigation and Reperfusion Gain in Myocardial Infarction (PARADIGM) trial.” J Am Coll Cardiol 32, no. 7 (December 1998): 2003–10. https://doi.org/10.1016/s0735-1097(98)00474-4.Full Text Link to Item
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Alexander, J. H., A. B. Greenbaum, M. P. Hudson, D. F. Kong, J. M. Miller, C. Y. Tung, and D. J. Whellan. “Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998.” Am Heart J 136, no. 1 (July 1998): 176–79. https://doi.org/10.1016/s0002-8703(98)70199-1.Full Text Link to Item
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Alexander, J. H., A. B. Greenbaum, M. P. Hudson, D. F. Kong, J. M. Miller, C. Y. Tung, and D. J. Whellan. “Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998.” Am Heart J 135, no. 6 Pt 1 (June 1998): 1099–1114. https://doi.org/10.1016/s0002-8703(98)70079-1.Full Text Link to Item
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Alexander, J. H., K. Alexander, D. F. Kong, C. Y. Tung, and D. Whellan. “Session highlights from the American Heart Association Scientific Sessions: November 9-12, 1997.” Am Heart J 135, no. 1 (January 1998): 157–80. https://doi.org/10.1016/s0002-8703(98)70357-6.Full Text Link to Item
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Alexander, J. H., and R. A. Harrington. “Antiplatelet and antithrombin therapies in the acute coronary syndromes.” Curr Opin Cardiol 12, no. 4 (July 1997): 427–37.Link to Item
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Alexander, J. H., and R. A. Harrington. “Adjunctive Antiplatelet Therapy in Acute Myocardial Infarction: The Road to Improved Infarct-Related Artery Patency.” J Thromb Thrombolysis 4, no. 3/4 (1997): 353–55. https://doi.org/10.1023/a:1008845315933.Full Text Link to Item
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Other Articles
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Castleberry, Anthony W., Judson B. Williams, Mani A. Daneshmand, Emily Honeycutt, Linda K. Shaw, Zainab Samad, Renato D. Lopes, et al. “Response to letter regarding article, "surgical revascularization is associated with maximal survival in patients with ischemic mitral regurgitation: a 20-year experience".” Circulation, March 17, 2015. https://doi.org/10.1161/CIRCULATIONAHA.114.013125.Full Text Link to Item
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Conference Papers
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Marquis-Gravel, Guillaume, Laurie-Anne Boivin-Proulx, Zhen Huang, Steven L. Zelenkofske, A Michael Lincoff, Roxana Mehran, P Gabriel Steg, Christoph Bode, John H. Alexander, and Thomas J. Povsic. “Femoral Vascular Closure Devices and Bleeding, Hemostasis, and Ambulation Following Percutaneous Coronary Intervention.” In J Am Heart Assoc, 12:e025666, 2023. https://doi.org/10.1161/JAHA.122.025666.Full Text Link to Item
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Melloni, Chiara, Allison Dunning, Christopher B. Granger, Laine Thomas, Michel G. Khouri, David A. Garcia, Elaine M. Hylek, et al. “Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial.” In Am J Med, 130:1440-1448.e1, 2017. https://doi.org/10.1016/j.amjmed.2017.06.026.Full Text Link to Item
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Avezum, Alvaro, Renato D. Lopes, Phillip J. Schulte, Fernando Lanas, Bernard J. Gersh, Michael Hanna, Prem Pais, et al. “Apixaban in Comparison With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: Findings From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial.” In Circulation, 132:624–32, 2015. https://doi.org/10.1161/CIRCULATIONAHA.114.014807.Full Text Link to Item
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Hijazi, Ziad, Lars Wallentin, Agneta Siegbahn, Ulrika Andersson, John H. Alexander, Dan Atar, Bernard J. Gersh, et al. “High-sensitivity troponin T and risk stratification in patients with atrial fibrillation during treatment with apixaban or warfarin.” In J Am Coll Cardiol, 63:52–61, 2014. https://doi.org/10.1016/j.jacc.2013.07.093.Full Text Link to Item
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Preprints
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Jhand, Aravdeep S., Waiel Abusnina, Hyo Jung Tak, Arslan Ahmed, Mahmoud Ismayl, S Elissa Altin, Matthew W. Sherwood, et al. “Impact of Anemia on Outcomes and Resource Utilization in Patients with Myocardial Infarction: A National Database Analysis.” Cold Spring Harbor Laboratory, March 3, 2023. https://doi.org/10.1101/2023.02.28.23286603.Full Text
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