John Hunter Peel Alexander

John Hunter Peel Alexander
Professor of Medicine

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Current Appointments & Affiliations

Professor of Medicine, Medicine, Cardiology, Medicine 2014
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 1996

Contact Information

200 Morris Street, Durham, NC 27701
Duke Box 17969, Durham, NC 27715
john.h.alexander@duke.edu (919) 668-8955
DCRI Profile
Department of Medicine (Cardiology) Profile

Background
Education, Training, & Certifications
- Fellow in Cardiology, Medicine, Duke University 1996 - 2000
- Medical Resident, Medicine, Children's Hospital Boston 1993 - 1996
- M.D., University of Pennsylvania 1993
Duke Appointment History
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2010 - 2014
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2006 - 2010
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2000 - 2006
Recognition
In the News
- MAR 20, 2017 Duke Health News
  
  Drug Could Reduce Serious Complication in Cardiac Bypass Patients
Expertise
Subject Headings
Global Scholarship
- Expertise
  - United States of America (Country)
- Research
  - United States of America (Country)
Research
Selected Grants
- Postdoctoral Training in Cardiovascular Clinical Research awarded by National Institutes of Health 2003 - 2024
- CSL112_STEMI awarded by CSL Behring LLC 2017 - 2022
- Duke Resident Physician-Scientist Program- NHLBI awarded by National Institutes of Health 2018 - 2022
- Increasing the Quality and Efficiency of Clinical Trials (R18) awarded by Food and Drug Administration 2014 - 2019
- Myocardial Ischemia and Transfusion (MINT) awarded by Rutgers, The State University of New Jersey 2016 - 2019
- Core Clinical Centers for the CTSN awarded by National Institutes of Health 2007 - 2018
- Genetics Myocardial Adverse Outcomes/Graft Failure-CABG awarded by National Institutes of Health 2004 - 2011
Publications & Artistic Works
Selected Publications
- Academic Articles
  - DeRose, JJ, Mancini, DM, Chang, HL, Argenziano, M, Dagenais, F, Ailawadi, G, Perrault, LP, Parides, MK, Taddei-Peters, WC, Mack, MJ, Glower, DD, Yerokun, BA, Atluri, P, Mullen, JC, Puskas, JD, O'Sullivan, K, Sledz, NM, Tremblay, H, Moquete, E, Ferket, BS, Moskowitz, AJ, Iribarne, A, Gelijns, AC, O'Gara, PT, Blackstone, EH, Gillinov, AM, Miller, MA, Buxton, D, Connolly, A, Geller, NL, Gordon, D, Jeffries, NO, Lee, A, Moy, CS, Gombos, IK, Ralph, J, Weisel, R, Gardner, TJ, Rose, EA, Ascheim, DD, Bagiella, E, Chang, H, Chase, M, Dobrev, E, Goldfarb, S, Gupta, L, Kirkwood, K, Levitan, R, Overbey, J, Santos, M, Weglinski, M, Williams, P, Wood, C, Ye, X, Mack, M, Adame, T, Settele, N, Adams, J, Ryan, W, Smith, RL, Grayburn, P, Chen, FY, Nohria, A, Cohn, L, Shekar, P, Aranki, S, Couper, G, Davidson, M, Bolman, RM, Burgess, A, Conboy, D, Blackwell, R, Kerzner, R, Banbury, M, Squire, AM, Lytle, B, Mihaljevic, T, Lackner, P, Berroteran, L, Dolney, D, Fleming, S, Palumbo, R, Whitman, C, Sankovic, K, Sweeney, DK, Pattakos, G, Williams, M, Goldsmith, L, Smith, CR, Naka, Y, Stewart, A, Schwartz, A, Bell, D, Van Patten, D, Sreekanth, S, Smith, PK, Alexander, JH, Milano, CA, Mathew, JP, and Harrison, JK. "Pacemaker Implantation After Mitral Valve Surgery With Atrial Fibrillation Ablation(Accepted)." Journal of the American College of Cardiology 73, no. 19 (May 21, 2019): 2427-2435. Full Text
  - Guimarães, PO, Lopes, RD, Alexander, JH, Thomas, L, Hellkamp, AS, Hijazi, Z, Hylek, EM, Gersh, BJ, Garcia, DA, Verheugt, FWA, Hanna, M, Flaker, G, Vinereanu, D, and Granger, CB. "International normalized ratio control and subsequent clinical outcomes in patients with atrial fibrillation using warfarin." Journal of Thrombosis and Thrombolysis (April 10, 2019). Full Text
  - Lopes, RD, Heizer, G, Aronson, R, Vora, AN, Massaro, T, Mehran, R, Goodman, SG, Windecker, S, Darius, H, Li, J, Averkov, O, Bahit, MC, Berwanger, O, Budaj, A, Hijazi, Z, Parkhomenko, A, Sinnaeve, P, Storey, RF, Thiele, H, Vinereanu, D, Granger, CB, Alexander, JH, and AUGUSTUS Investigators, . "Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation." The New England Journal of Medicine 380, no. 16 (April 2019): 1509-1524. Full Text
  - Washam, JB, Hohnloser, SH, Lopes, RD, Wojdyla, DM, Vinereanu, D, Alexander, JH, Gersh, BJ, Hanna, M, Horowitz, J, Hylek, EM, Xavier, D, Verheugt, FWA, Wallentin, L, Granger, CB, and ARISTOTLE Committees and Investigators, . "Interacting medication use and the treatment effects of apixaban versus warfarin: results from the ARISTOTLE Trial." Journal of Thrombosis and Thrombolysis 47, no. 3 (April 2019): 345-352. Full Text
  - Guimarães, PO, Pokorney, SD, Lopes, RD, Wojdyla, DM, Gersh, BJ, Giczewska, A, Carnicelli, A, Lewis, BS, Hanna, M, Wallentin, L, Vinereanu, D, Alexander, JH, and Granger, CB. "Efficacy and safety of apixaban vs warfarin in patients with atrial fibrillation and prior bioprosthetic valve replacement or valve repair: Insights from the ARISTOTLE trial." Clinical Cardiology (March 24, 2019). Full Text
  - Hohnloser, SH, Fudim, M, Alexander, JH, Wojdyla, DM, Ezekowitz, JA, Hanna, M, Atar, D, Hijazi, Z, Bahit, MC, Al-Khatib, SM, Lopez-Sendon, JL, Wallentin, L, Granger, CB, and Lopes, RD. "Efficacy and Safety of Apixaban versus Warfarin in Patients with Atrial Fibrillation and Extremes in Body Weight: Insights from the ARISTOTLE Trial." Circulation (February 18, 2019). Full Text
  - Alexander, KP, Brouwer, MA, Mulder, H, Vinereanu, D, Lopes, RD, Proietti, M, Al-Khatib, SM, Hijazi, Z, Halvorsen, S, Hylek, EM, Verheugt, FWA, Alexander, JH, Wallentin, L, Granger, CB, and ARISTOTLE Investigators, . "Outcomes of apixaban versus warfarin in patients with atrial fibrillation and multi-morbidity: Insights from the ARISTOTLE trial." American Heart Journal 208 (February 2019): 123-131. Full Text
  - Christersson, C, Wallentin, L, Andersson, U, Alexander, JH, Alings, M, De Caterina, R, Gersh, BJ, Granger, CB, Halvorsen, S, Hanna, M, Huber, K, Hylek, EM, Lopes, RD, Oh, B-H, and Siegbahn, A. "Effect of apixaban compared with warfarin on coagulation markers in atrial fibrillation." Heart (British Cardiac Society) 105, no. 3 (February 2019): 235-242. Full Text
  - Fanaroff, AC, Clare, R, Pieper, KS, Mahaffey, KW, Melloni, C, Green, JB, Alexander, JH, Jones, WS, Harrison, RW, Mehta, RH, Povsic, TJ, Moreira, HG, Al-Khatib, SM, Roe, MT, Kong, DF, Mathews, R, Tricoci, P, Holman, RR, Wallentin, L, Held, C, Califf, RM, Alexander, KP, and Lopes, RD. "Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9259 Deaths in 9 Trials." Circulation 139, no. 7 (February 2019): 863-873. Full Text
  - Gibson, CM, Kerneis, M, Yee, MK, Daaboul, Y, Korjian, S, Mehr, AP, Tricoci, P, Alexander, JH, Kastelein, JJP, Mehran, R, Bode, C, Lewis, BS, Mehta, R, Duffy, D, Feaster, J, Halabi, M, Angiolillo, DJ, Duerschmied, D, Ophuis, TO, and Merkely, B. "The CSL112-2001 trial: Safety and tolerability of multiple doses of CSL112 (apolipoprotein A-I [human]), an intravenous formulation of plasma-derived apolipoprotein A-I, among subjects with moderate renal impairment after acute myocardial infarction." American Heart Journal 208 (February 2019): 81-90. Full Text
  - Ranney, DN, Williams, JB, Mulder, H, Wojdyla, D, Cox, ML, Gibson, CM, Mack, MJ, Daneshmand, MA, Alexander, JH, and Lopes, RD. "Comparison of Outcomes and Frequency of Graft Failure With Use of Free Versus In Situ Internal Mammary Artery Bypass Conduits (from the PREVENT IV Trial)." The American Journal of Cardiology 123, no. 4 (February 2019): 571-575. Full Text
  - Alexander, JH. "Antithrombotic Therapy Following CABG: For the Patient, Not the Bypass Graft." Journal of the American College of Cardiology 73, no. 2 (January 2019): 131-133. Full Text
  - McGuire, DK, Alexander, JH, Johansen, OE, Perkovic, V, Rosenstock, J, Cooper, ME, Wanner, C, Kahn, SE, Toto, RD, Zinman, B, Baanstra, D, Pfarr, E, Schnaidt, S, Meinicke, T, George, JT, von Eynatten, M, Marx, N, and CARMELINA Investigators, . "Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA." Circulation 139, no. 3 (January 2019): 351-361. Full Text
  - Rosenstock, J, Perkovic, V, Johansen, OE, Cooper, ME, Kahn, SE, Marx, N, Alexander, JH, Pencina, M, Toto, RD, Wanner, C, Zinman, B, Woerle, HJ, Baanstra, D, Pfarr, E, Schnaidt, S, Meinicke, T, George, JT, von Eynatten, M, McGuire, DK, and CARMELINA Investigators, . "Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial." Jama 321, no. 1 (January 2019): 69-79. Full Text
  - Smith, PJ, Browndyke, JN, Monge, ZA, Harshbarger, TB, James, ML, Gaca, JG, Alexander, JH, Berger, MM, Newman, MF, Milano, CA, Mathew, JP, and Neurologic Outcomes Research Group (NORG), . "Longitudinal Changes in Regional Cerebral Perfusion and Cognition After Cardiac Operation." The Annals of Thoracic Surgery 107, no. 1 (January 2019): 112-118. Full Text Open Access Copy
  - Lopes, RD, de Barros E Silva, PGM, de Andrade Jesuíno, I, Santucci, EV, Barbosa, LM, Damiani, LP, Nakagawa Santos, RH, Laranjeira, LN, Dall Orto, FTC, Beraldo de Andrade, P, de Castro Bienert, IR, Alexander, JH, Granger, CB, and Berwanger, O. "Timing of Loading Dose of Atorvastatin in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes: Insights From the SECURE-PCI Randomized Clinical Trial." Jama Cardiology 3, no. 11 (November 2018): 1113-1118. Full Text
  - Minter, S, Armour, A, Tinnemore, A, Strub, K, Crowley, AL, Bloomfield, GS, Alexander, JH, Douglas, PS, Kisslo, JA, Velazquez, EJ, and Samad, Z. "Crowdsourcing consensus: proposal of a novel method for assessing accuracy in echocardiography interpretation." The International Journal of Cardiovascular Imaging 34, no. 11 (November 2018): 1725-1730. Full Text
  - Sharma, A, Hijazi, Z, Andersson, U, Al-Khatib, SM, Lopes, RD, Alexander, JH, Held, C, Hylek, EM, Leonardi, S, Hanna, M, Ezekowitz, JA, Siegbahn, A, Granger, CB, and Wallentin, L. "Use of Biomarkers to Predict Specific Causes of Death in Patients With Atrial Fibrillation." Circulation 138, no. 16 (October 2018): 1666-1676. Full Text
  - Samad, Z, Shaw, LK, Phelan, M, Glower, DD, Ersboll, M, Toptine, JH, Alexander, JH, Kisslo, JA, Wang, A, Mark, DB, and Velazquez, EJ. "Long-term outcomes of mitral regurgitation by type and severity." American Heart Journal 203 (September 2018): 39-48. Full Text
  - Fanaroff, AC, Steffel, J, Alexander, JH, Lip, GYH, Califf, RM, and Lopes, RD. "Stroke prevention in atrial fibrillation: re-defining 'real-world data' within the broader data universe." European Heart Journal 39, no. 32 (August 2018): 2932-2941. Full Text
  - Horowitz, JD, De Caterina, R, Heresztyn, T, Alexander, JH, Andersson, U, Lopes, RD, Steg, PG, Hylek, EM, Mohan, P, Hanna, M, Jansky, P, Granger, CB, Wallentin, L, and ARISTOTLE Investigators, . "Asymmetric and Symmetric Dimethylarginine Predict Outcomes in Patients With Atrial Fibrillation: An ARISTOTLE Substudy." Journal of the American College of Cardiology 72, no. 7 (August 2018): 721-733. Full Text
  - Vinereanu, D, Wang, A, Mulder, H, Lopes, RD, Jansky, P, Lewis, BS, Gersh, BJ, Avezum, A, Hanna, M, Held, C, Wallentin, L, Granger, CB, and Alexander, JH. "Outcomes in anticoagulated patients with atrial fibrillation and with mitral or aortic valve disease." Heart (British Cardiac Society) 104, no. 15 (August 2018): 1292-1299. Full Text
  - Inohara, T, Pieper, K, Wojdyla, DM, Patel, MR, Jones, WS, Tricoci, P, Mahaffey, KW, James, SK, Alexander, JH, Lopes, RD, Wallentin, L, Ohman, EM, Roe, MT, and Vemulapalli, S. "Incidence, timing, and type of first and recurrent ischemic events in patients with and without peripheral artery disease after an acute coronary syndrome." American Heart Journal 201 (July 2018): 25-32. Full Text
  - Carson, JL, Stanworth, SJ, Alexander, JH, Roubinian, N, Fergusson, DA, Triulzi, DJ, Goodman, SG, Rao, SV, Doree, C, and Hebert, PC. "Clinical trials evaluating red blood cell transfusion thresholds: An updated systematic review and with additional focus on patients with cardiovascular disease." American Heart Journal 200 (June 2018): 96-101. Full Text
  - Lopes, RD, Vora, AN, Liaw, D, Granger, CB, Darius, H, Goodman, SG, Mehran, R, Windecker, S, and Alexander, JH. "An open-Label, 2 × 2 factorial, randomized controlled trial to evaluate the safety of apixaban vs. vitamin K antagonist and aspirin vs. placebo in patients with atrial fibrillation and acute coronary syndrome and/or percutaneous coronary intervention: Rationale and design of the AUGUSTUS trial." American Heart Journal 200 (June 2018): 17-23. Full Text
  - Gurbel, PA, Tantry, US, D'Andrea, D, Chung, T, Alexander, JH, Bliden, KP, Wright, SD, and Tricoci, P. "Evaluation of potential antiplatelet effects of CSL112 (Apolipoprotein A-I [Human]) in patients with atherosclerosis: results from a phase 2a study." Journal of Thrombosis and Thrombolysis 45, no. 4 (May 2018): 469-476. Full Text
  - Wang, A, Wu, A, Wojdyla, D, Lopes, RD, Newby, LK, Newman, MF, Smith, PK, and Alexander, JH. "Dual antiplatelet therapy for perioperative myocardial infarction following CABG surgery." American Heart Journal 199 (May 2018): 150-155. Full Text
  - Alexander, JH. "Ticagrelor Following Coronary Artery Bypass Grafting: For Better Vein Graft Patency or Better Patient Outcomes?." Jama 319, no. 16 (April 2018): 1661-1662. Full Text
  - Berwanger, O, Santucci, EV, de Barros E Silva, PGM, Jesuíno, IDA, Damiani, LP, Barbosa, LM, Santos, RHN, Laranjeira, LN, Egydio, FDM, Borges de Oliveira, JA, Dall Orto, FTC, Beraldo de Andrade, P, Bienert, IRDC, Bosso, CE, Mangione, JA, Polanczyk, CA, Sousa, AGDMR, Kalil, RAK, Santos, LDM, Sposito, AC, Rech, RL, Sousa, ACS, Baldissera, F, Nascimento, BR, Giraldez, RRCV, Cavalcanti, AB, Pereira, SB, Mattos, LA, Armaganijan, LV, Guimarães, HP, Sousa, JEMR, Alexander, JH, Granger, CB, Lopes, RD, and SECURE-PCI Investigators, . "Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome: The SECURE-PCI Randomized Clinical Trial." Jama 319, no. 13 (April 2018): 1331-1340. Full Text
  - Berwanger, O, de Barros E Silva, PGM, Dall Orto, FTC, de Andrade, PB, de Castro Bienert, IR, Bosso, CE, Mangione, J, Polanczyk, CA, Sousa, A, Kalil, R, de Moura Santos, L, Sposito, AC, Rech, RL, Sousa, ACS, Baldissera, F, Nascimento, BR, de Andrade Jesuíno, I, Santucci, EV, Damiani, LP, Laranjeira, LN, Borges de Oliveira, JA, Giraldez, RR, Cavalcanti, AB, Pereira, SB, Mattos, LA, Armaganijan, LV, Guimarães, HP, Sousa, JE, Alexander, JH, Granger, CB, and Lopes, RD. "Rationale and design of the Statins Evaluation in Coronary procedUres and REvascularization: The SECURE-PCI Trial." American Heart Journal 198 (April 2018): 129-134. Full Text
  - Goto, S, Merrill, P, Wallentin, L, Wojdyla, DM, Hanna, M, Avezum, A, Easton, JD, Harjola, V-P, Huber, K, Lewis, BS, Parkhomenko, A, Zhu, J, Granger, CB, Lopes, RD, and Alexander, JH. "Antithrombotic therapy use and clinical outcomes following thrombo-embolic events in patients with atrial fibrillation: insights from ARISTOTLE." European Heart Journal. Cardiovascular Pharmacotherapy 4, no. 2 (April 2018): 75-81. Full Text
  - Gulack, BC, Kirkwood, KA, Shi, W, Smith, PK, Alexander, JH, Burks, SG, Gelijns, AC, Thourani, VH, Bell, D, Greenberg, A, Goldfarb, SD, Mayer, ML, Bowdish, ME, and Cardiothoracic Surgical Trials Network (CTSN), . "Secondary surgical-site infection after coronary artery bypass grafting: A multi-institutional prospective cohort study." The Journal of Thoracic and Cardiovascular Surgery 155, no. 4 (April 2018): 1555-1562.e1. Full Text
  - Rosenstock, J, Perkovic, V, Alexander, JH, Cooper, ME, Marx, N, Pencina, MJ, Toto, RD, Wanner, C, Zinman, B, Baanstra, D, Pfarr, E, Mattheus, M, Broedl, UC, Woerle, H-J, George, JT, von Eynatten, M, McGuire, DK, and CARMELINA® investigators, . "Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA®): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk." Cardiovascular Diabetology 17, no. 1 (March 14, 2018): 39-null. Full Text
  - Chiarito, M, Cao, D, Cannata, F, Godino, C, Lodigiani, C, Ferrante, G, Lopes, RD, Alexander, JH, Reimers, B, Condorelli, G, and Stefanini, GG. "Direct Oral Anticoagulants in Addition to Antiplatelet Therapy for Secondary Prevention After Acute Coronary Syndromes: A Systematic Review and Meta-analysis." Jama Cardiology 3, no. 3 (March 2018): 234-241. Full Text
  - Kopin, D, Jones, WS, Sherwood, MW, Wojdyla, DM, Wallentin, L, Lewis, BS, Verheugt, FWA, Vinereanu, D, Bahit, MC, Halvorsen, S, Huber, K, Parkhomenko, A, Granger, CB, Lopes, RD, and Alexander, JH. "Percutaneous coronary intervention and antiplatelet therapy in patients with atrial fibrillation receiving apixaban or warfarin: Insights from the ARISTOTLE trial." American Heart Journal 197 (March 2018): 133-141. Full Text
  - Lopes, RD, Rordorf, R, De Ferrari, GM, Leonardi, S, Thomas, L, Wojdyla, DM, Ridefelt, P, Lawrence, JH, De Caterina, R, Vinereanu, D, Hanna, M, Flaker, G, Al-Khatib, SM, Hohnloser, SH, Alexander, JH, Granger, CB, Wallentin, L, and ARISTOTLE Committees and Investigators, . "Digoxin and Mortality in Patients With Atrial Fibrillation." Journal of the American College of Cardiology 71, no. 10 (March 2018): 1063-1074. Full Text
  - Rao, MP, Vinereanu, D, Wojdyla, DM, Alexander, JH, Atar, D, Hylek, EM, Hanna, M, Wallentin, L, Lopes, RD, Gersh, BJ, Granger, CB, and Apixaban for Reduction in Stroke Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Investigators, . "Clinical Outcomes and History of Fall in Patients with Atrial Fibrillation Treated with Oral Anticoagulation: Insights From the ARISTOTLE Trial." The American Journal of Medicine 131, no. 3 (March 2018): 269-275.e2. Full Text
  - Sherwood, MW, Lopes, RD, Sun, JL, Liaw, D, Harrington, RA, Wallentin, L, Laskowitz, DT, James, SK, Goodman, SG, Darius, H, Lewis, BS, Gibson, CM, Pieper, KS, and Alexander, JH. "Apixaban following acute coronary syndromes in patients with prior stroke: Insights from the APPRAISE-2 trial." American Heart Journal 197 (March 2018): 1-8. Full Text
  - Alexander, JH, Corrigan-Curay, J, and McClellan, M. "The Clinical Trials Transformation Initiative: Looking back, looking forward." Clinical trials (London, England) 15, no. 1_suppl (February 2018): 3-4. Full Text
  - Browndyke, JN, Berger, M, Smith, PJ, Harshbarger, TB, Monge, ZA, Panchal, V, Bisanar, TL, Glower, DD, Alexander, JH, Cabeza, R, Welsh-Bohmer, K, Newman, MF, Mathew, JP, and Duke Neurologic Outcomes Research Group (NORG), . "Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults." Human Brain Mapping 39, no. 2 (February 2018): 985-1003. Full Text Open Access Copy
  - Hijazi, Z, Oldgren, J, Lindbäck, J, Alexander, JH, Connolly, SJ, Eikelboom, JW, Ezekowitz, MD, Held, C, Hylek, EM, Lopes, RD, Yusuf, S, Granger, CB, Siegbahn, A, Wallentin, L, and ARISTOTLE and RE-LY Investigators, . "A biomarker-based risk score to predict death in patients with atrial fibrillation: the ABC (age, biomarkers, clinical history) death risk score." European Heart Journal 39, no. 6 (February 2018): 477-485. Full Text
  - Pol, T, Held, C, Westerbergh, J, Lindbäck, J, Alexander, JH, Alings, M, Erol, C, Goto, S, Halvorsen, S, Huber, K, Hanna, M, Lopes, RD, Ruzyllo, W, Granger, CB, and Hijazi, Z. "Dyslipidemia and Risk of Cardiovascular Events in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Therapy: Insights From the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) Trial." Journal of the American Heart Association 7, no. 3 (February 2018). Full Text
  - Sandhu, RK, Ezekowitz, JA, Hijazi, Z, Westerbergh, J, Aulin, J, Alexander, JH, Granger, CB, Halvorsen, S, Hanna, MS, Lopes, RD, Siegbahn, A, and Wallentin, L. "Obesity paradox on outcome in atrial fibrillation maintained even considering the prognostic influence of biomarkers: insights from the ARISTOTLE trial." Open Heart 5, no. 2 (January 2018): e000908-null. Full Text
  - Gaudino, M, Alexander, JH, Bakaeen, FG, Ballman, K, Barili, F, Calafiore, AM, Davierwala, P, Goldman, S, Kappetein, P, Lorusso, R, Mylotte, D, Pagano, D, Ruel, M, Schwann, T, Suma, H, Taggart, DP, Tranbaugh, RF, and Fremes, S. "Randomized comparison of the clinical outcome of single versus multiple arterial grafts: the ROMA trial-rationale and study protocol." European Journal of Cardio Thoracic Surgery : Official Journal of the European Association for Cardio Thoracic Surgery 52, no. 6 (December 2017): 1031-1040. (Review) Full Text
  - Vinereanu, D, Lopes, RD, Mulder, H, Gersh, BJ, Hanna, M, de Barros E Silva, PGM, Atar, D, Wallentin, L, Granger, CB, Alexander, JH, and ARISTOTLE Investigators, . "Echocardiographic Risk Factors for Stroke and Outcomes in Patients With Atrial Fibrillation Anticoagulated With Apixaban or Warfarin." Stroke 48, no. 12 (December 2017): 3266-3273. Full Text
  - Mehta, RH, Alexander, JH, and LEVO-CTS Steering Committee Members and Trial Investigators, . "Levosimendan in Cardiac Surgery." The New England Journal of Medicine 377, no. 19 (November 9, 2017): 1900-1901. (Letter) Full Text
  - Koshizaka, M, Lopes, RD, Newby, LK, Clare, RM, Schulte, PJ, Tricoci, P, Mahaffey, KW, Ogawa, H, Moliterno, DJ, Giugliano, RP, Huber, K, James, S, Harrington, RA, and Alexander, JH. "Obesity, Diabetes, and Acute Coronary Syndrome: Differences Between Asians and Whites." The American Journal of Medicine 130, no. 10 (October 2017): 1170-1176. Full Text
  - Manning, MW, Cooter, M, Mathew, J, Alexander, J, Peterson, E, Ferguson, TB, Lopes, R, and Podgoreanu, M. "Angiotensin Receptor Blockade Improves Cardiac Surgical Outcomes in Patients With Metabolic Syndrome." The Annals of Thoracic Surgery 104, no. 1 (July 2017): 98-105. Full Text
  - Hijazi, Z, Lindahl, B, Oldgren, J, Andersson, U, Lindbäck, J, Granger, CB, Alexander, JH, Gersh, BJ, Hanna, M, Harjola, V-P, Hylek, EM, Lopes, RD, Siegbahn, A, and Wallentin, L. "Repeated Measurements of Cardiac Biomarkers in Atrial Fibrillation and Validation of the ABC Stroke Score Over Time." Journal of the American Heart Association 6, no. 6 (June 23, 2017). Full Text
  - Ailawadi, G, Chang, HL, O'Gara, PT, O'Sullivan, K, Woo, YJ, DeRose, JJ, Parides, MK, Thourani, VH, Robichaud, S, Gillinov, AM, Taddei-Peters, WC, Miller, MA, Perrault, LP, Smith, RL, Goldsmith, L, Horvath, KA, Doud, K, Baio, K, Gelijns, AC, Moskowitz, AJ, Bagiella, E, Alexander, JH, and Iribarne, A. "Pneumonia after cardiac surgery: Experience of the National Institutes of Health/Canadian Institutes of Health Research Cardiothoracic Surgical Trials Network." The Journal of Thoracic and Cardiovascular Surgery 153, no. 6 (June 2017): 1384-1391.e3. Full Text
  - Guimarães, PO, Lopes, RD, Wojdyla, DM, Abdul-Rahim, AH, Connolly, SJ, Flaker, GC, Wang, J, Hanna, M, Granger, CB, Wallentin, L, Lees, KR, Alexander, JH, and McMurray, JJV. "Effect of Apixaban on All-Cause Death in Patients with Atrial Fibrillation: a Meta-Analysis Based on Imputed Placebo Effect." Cardiovascular Drugs and Therapy 31, no. 3 (June 2017): 295-301. Full Text
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  - Vavalle, JP, Povsic, TJ, Aberle, LH, Zelenkofske, SL, Mehran, R, Kasprzak, JD, Bode, C, Buller, CE, Montalescot, G, Cornel, JH, Becker, RC, Alexander, JH, and Cohen, MG. "Safety of very early sheath removal in patients treated with REG1 for acute coronary syndromes: insights from the RADAR trial." J Invasive Cardiol 25, no. 11 (November 2013): 593-599. Link to Item
  - Williams, JB, Lopes, RD, Hafley, GE, Bruce Ferguson, T, Mack, MJ, Michael Gibson, C, Harrington, RA, Peterson, ED, Smith, PK, Mehta, RH, and Alexander, JH. "Relationship between postoperative clopidogrel use and subsequent angiographic and clinical outcomes following coronary artery bypass grafting." Journal of Thrombosis and Thrombolysis 36, no. 4 (November 1, 2013): 384-393. Full Text
  - Williams, JB, Lopes, RD, Hafley, GE, Ferguson, TB, Mack, MJ, Gibson, CM, Harrington, RA, Peterson, ED, Smith, PK, Mehta, RH, and Alexander, JH. "Relationship between postoperative clopidogrel use and subsequent angiographic and clinical outcomes following coronary artery bypass grafting." Journal of Thrombosis and Thrombolysis 36, no. 4 (November 2013): 384-393. Full Text
  - Alexander, JH, Levy, E, Lawrence, J, Hanna, M, Waclawski, AP, Wang, J, Califf, RM, Wallentin, L, and Granger, CB. "Documentation of study medication dispensing in a prospective large randomized clinical trial: experiences from the ARISTOTLE Trial." American Heart Journal 166, no. 3 (September 2013): 559-565. Full Text
  - Steinberg, BA, Hasselblad, V, Atwater, BD, Bahnson, TD, Washam, JB, Alexander, JH, Daubert, JP, and Piccini, JP. "Dabigatran for periprocedural anticoagulation following radiofrequency ablation for atrial fibrillation: a meta-analysis of observational studies." Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing 37, no. 3 (September 2013): 213-221. Full Text
  - Al-Khatib, SM, Thomas, L, Wallentin, L, Lopes, RD, Gersh, B, Garcia, D, Ezekowitz, J, Alings, M, Yang, H, Alexander, JH, Flaker, G, Hanna, M, and Granger, CB. "Outcomes of apixaban vs. warfarin by type and duration of atrial fibrillation: results from the ARISTOTLE trial." European Heart Journal 34, no. 31 (August 2013): 2464-2471. Full Text
  - Povsic, TJ, Vavalle, JP, Aberle, LH, Kasprzak, JD, Cohen, MG, Mehran, R, Bode, C, Buller, CE, Montalescot, G, Cornel, JH, Rynkiewicz, A, Ring, ME, Zeymer, U, Natarajan, M, Delarche, N, Zelenkofske, SL, Becker, RC, Alexander, JH, and RADAR Investigators, . "A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial." Eur Heart J 34, no. 31 (August 2013): 2481-2489. Full Text Link to Item
  - Alexander, JH. "The editorialist replies." New England Journal of Medicine 369, no. 2 (July 23, 2013): 197-null. (Letter) Full Text
  - Alexander, JH. "Off-pump or on-pump coronary-artery bypass grafting." The New England Journal of Medicine 369, no. 2 (July 2013): 197-null. (Letter) Full Text
  - de Souza Brito, F, Lopes, RD, and Alexander, JH. "The safety and efficacy of apixaban : where do we stand in 2013?." Expert Opin Drug Saf 12, no. 4 (July 2013): 559-567. (Review) Full Text Link to Item
  - Alexander, JH, and Peterson, ED. "Surgery. Translating trials to clinical practice in cardiac surgery." Nature Reviews. Cardiology 10, no. 6 (June 2013): 306-307. Full Text
  - Oldgren, J, Wallentin, L, Alexander, JH, James, S, Jönelid, B, Steg, G, and Sundström, J. "New oral anticoagulants in addition to single or dual antiplatelet therapy after an acute coronary syndrome: a systematic review and meta-analysis." European Heart Journal 34, no. 22 (June 2013): 1670-1680. (Review) Full Text
  - Wallentin, L, Lopes, RD, Hanna, M, Thomas, L, Hellkamp, A, Nepal, S, Hylek, EM, Al-Khatib, SM, Alexander, JH, Alings, M, Amerena, J, Ansell, J, Aylward, P, Bartunek, J, Commerford, P, De Caterina, R, Erol, C, Harjola, V-P, Held, C, Horowitz, JD, Huber, K, Husted, S, Keltai, M, Lanas, F, Lisheng, L, McMurray, JJV, Oh, B-H, Rosenqvist, M, Ruzyllo, W, Steg, PG, Vinereanu, D, Xavier, D, Granger, CB, and Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Investigators, . "Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for stroke prevention in atrial fibrillation." Circulation 127, no. 22 (June 2013): 2166-2176. Full Text
  - Harskamp, RE, Lopes, RD, Baisden, CE, de Winter, RJ, and Alexander, JH. "Saphenous vein graft failure after coronary artery bypass surgery: pathophysiology, management, and future directions." Annals of Surgery 257, no. 5 (May 2013): 824-833. (Review) Full Text
  - Harskamp, RE, Williams, JB, Hill, RC, de Winter, RJ, Alexander, JH, and Lopes, RD. "Saphenous vein graft failure and clinical outcomes: toward a surrogate end point in patients following coronary artery bypass surgery?." American Heart Journal 165, no. 5 (May 2013): 639-643. Full Text
  - McMurray, JJV, Ezekowitz, JA, Lewis, BS, Gersh, BJ, van Diepen, S, Amerena, J, Bartunek, J, Commerford, P, Oh, B-H, Harjola, V-P, Al-Khatib, SM, Hanna, M, Alexander, JH, Lopes, RD, Wojdyla, DM, Wallentin, L, Granger, CB, and ARISTOTLE Committees and Investigators, . "Left ventricular systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with atrial fibrillation: insights from the ARISTOTLE trial." Circulation. Heart Failure 6, no. 3 (May 2013): 451-460. Full Text
  - Subherwal, S, Ohman, EM, Mahaffey, KW, Rao, SV, Alexander, JH, Wang, TY, Alexander, KP, Hasselblad, V, and Roe, MT. "Incorporation of bleeding as an element of the composite end point in clinical trials of antithrombotic therapies in patients with non-ST-segment elevation acute coronary syndrome: validity, pitfalls, and future approaches." American Heart Journal 165, no. 5 (May 2013): 644-654.e1. (Review) Full Text
  - Alexander, JH, Levy, E, Lawrence, J, Hanna, M, Waclawski, AP, Wang, J, Califf, RM, Wallentin, L, and Granger, CB. "Documentation of study medication dispensing in a prospective large randomized clinical trial: Experiences from the ARISTOTLE Trial." American Heart Journal 166, no. 3 (2013): 559-565.e1. Full Text
  - Alexander, JH, and Peterson, ED. "Surgery: Translating trials to clinical practice in cardiac surgery." Nature Reviews Cardiology 10, no. 6 (2013): 306-307. Full Text
  - Alexander, JH. "Clinical-outcome trials in cardiac surgery - Have we primed the pump?." New England Journal of Medicine 368, no. 13 (2013): 1247-1248. Full Text
  - Bahit, MC, Lopes, RD, Wojdyla, DM, Hohnloser, SH, Alexander, JH, Lewis, BS, Aylward, PE, Verheugt, FWA, Keltai, M, Diaz, R, Hanna, M, Granger, CB, and Wallentin, L. "Apixaban in patients with atrial fibrillation and prior coronary artery disease: Insights from the ARISTOTLE trial." International Journal of Cardiology (2013).
  - Garcia, DA, Wallentin, L, Lopes, RD, Thomas, L, Alexander, JH, Hylek, EM, Ansell, J, Hanna, M, Lanas, F, Flaker, G, Commerford, P, Xavier, D, Vinereanu, D, Yang, H, and Granger, CB. "Apixaban versus warfarin in patients with atrial fibrillation according to prior warfarin use: Results from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial." American Heart Journal 166, no. 3 (2013): 549-558. Full Text
  - Garcia, DA, Wallentin, L, Lopes, RD, Thomas, L, Alexander, JH, Hylek, EM, Ansell, J, Hanna, M, Lanas, F, Flaker, G, and al, E. "Apixaban versus warfarin in patients with atrial fibrillation according to prior warfarin use: Results from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial." American Heart Journal (2013). Full Text
  - Harskamp, RE, Bonatti, JO, Zhao, DX, Puskas, JD, Winter, RJD, Alexander, JH, and Halkos, ME. "Standardizing definitions for hybrid coronary revascularization." Journal of Thoracic and Cardiovascular Surgery (2013). Full Text
  - Harskamp, RE, Williams, JB, Hill, RC, Winter, RJD, Alexander, JH, and Lopes, RD. "Saphenous vein graft failure and clinical outcomes: Toward a surrogate end point in patients following coronary artery bypass surgery?." American Heart Journal 165, no. 5 (2013): 639-643. Full Text
  - Subherwal, S, Ohman, EM, Mahaffey, KW, Rao, SV, Alexander, JH, Wang, TY, Alexander, KP, Hasselblad, V, and Roe, MT. "Incorporation of bleeding as an element of the composite end point in clinical trials of antithrombotic therapies in patients with non-ST-segment elevation acute coronary syndrome: Validity, pitfalls, and future approaches." American Heart Journal 165, no. 5 (2013): 644-654.e1. Full Text
  - Williams, ES, Thompson, VP, Chiswell, KE, Alexander, JH, White, HD, Ohman, EM, and Al-Khatib, SM. "Rate versus rhythm control and outcomes in patients with atrial fibrillation and chronic kidney disease: data from the GUSTO-III Trial." Cardiology Journal 20, no. 4 (January 2013): 439-446. Full Text
  - Lopes, RD, Al-Khatib, SM, Wallentin, L, Yang, H, Ansell, J, Bahit, MC, De Caterina, R, Dorian, P, Easton, JD, Erol, C, Ezekowitz, JA, Gersh, BJ, Granger, CB, Hohnloser, SH, Horowitz, J, Hylek, EM, McMurray, JJV, Mohan, P, Vinereanu, D, and Alexander, JH. "Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: a secondary analysis of a randomised controlled trial." Lancet 380, no. 9855 (November 17, 2012): 1749-1758. Full Text Link to Item
  - Hess, CN, Becker, RC, Alexander, JH, and Lopes, RD. "Antithrombotic therapy in heparin-induced thrombocytopenia: guidelines translated for the clinician." J Thromb Thrombolysis 34, no. 4 (November 2012): 552-561. (Review) Full Text Link to Item
  - Hohnloser, SH, Hijazi, Z, Thomas, L, Alexander, JH, Amerena, J, Hanna, M, Keltai, M, Lanas, F, Lopes, RD, Lopez-Sendon, J, Granger, CB, and Wallentin, L. "Efficacy of apixaban when compared with warfarin in relation to renal function in patients with atrial fibrillation: insights from the ARISTOTLE trial." European Heart Journal 33, no. 22 (November 2012): 2821-2830. Full Text
  - Gutierrez, A, Tricoci, P, and Alexander, JHP. "Pentasaccharide Derivatives." (October 3, 2012): 128-149. (Chapter) Full Text
  - Hess, CN, Broderick, S, Piccini, JP, Alexander, KP, Newby, LK, Shaw, LK, Mahaffey, KW, Alexander, JH, Peterson, ED, Granger, CB, and Lopes, RD. "Antithrombotic therapy for atrial fibrillation and coronary artery disease in older patients." American Heart Journal 164, no. 4 (October 2012): 607-615. Full Text
  - Roe, MT, Armstrong, PW, Fox, KAA, White, HD, Prabhakaran, D, Goodman, SG, Cornel, JH, Bhatt, DL, Clemmensen, P, Martinez, F, Ardissino, D, Nicolau, JC, Boden, WE, Gurbel, PA, Ruzyllo, W, Dalby, AJ, McGuire, DK, Leiva-Pons, JL, Parkhomenko, A, Gottlieb, S, Topacio, GO, Hamm, C, Pavlides, G, Goudev, AR, Oto, A, Tseng, C-D, Merkely, B, Gasparovic, V, Corbalan, R, Cinteză, M, McLendon, RC, Winters, KJ, Brown, EB, Lokhnygina, Y, Aylward, PE, Huber, K, Hochman, JS, Ohman, EM, and TRILOGY ACS Investigators, . "Prasugrel versus clopidogrel for acute coronary syndromes without revascularization." The New England Journal of Medicine 367, no. 14 (October 2012): 1297-1309. Full Text
  - Lopes, RD, Williams, JB, Mehta, RH, Reyes, EM, Hafley, GE, Allen, KB, Mack, MJ, Peterson, ED, Harrington, RA, Gibson, CM, Califf, RM, Kouchoukos, NT, Ferguson, TB, Lorenz, TJ, and Alexander, JH. "Edifoligide and long-term outcomes after coronary artery bypass grafting: PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) 5-year results." American Heart Journal 164, no. 3 (September 2012): 379-386.e1. Full Text
  - Williams, JB, Peterson, ED, Brennan, JM, Sedrakyan, A, Tavris, D, Alexander, JH, Lopes, RD, Dokholyan, RS, Zhao, Y, O'Brien, SM, Michler, RE, Thourani, VH, Edwards, FH, Duggirala, H, Gross, T, Marinac-Dabic, D, and Smith, PK. "Association between endoscopic vs open vein-graft harvesting and mortality, wound complications, and cardiovascular events in patients undergoing CABG surgery." Jama 308, no. 5 (August 2012): 475-484. Full Text
  - Vavalle, JP, Rusconi, CP, Zelenkofske, S, Wargin, WA, Alexander, JH, and Becker, RC. "A phase 1 ascending dose study of a subcutaneously administered factor IXa inhibitor and its active control agent." J Thromb Haemost 10, no. 7 (July 2012): 1303-1311. Full Text Link to Item
  - Easton, JD, Lopes, RD, Bahit, MC, Wojdyla, DM, Granger, CB, Wallentin, L, Alings, M, Goto, S, Lewis, BS, Rosenqvist, M, Hanna, M, Mohan, P, Alexander, JH, Diener, H-C, and ARISTOTLE Committees and Investigators, . "Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial." The Lancet. Neurology 11, no. 6 (June 2012): 503-511. Full Text
  - Wiggins, NB, Granger, CB, and Alexander, JH. "Novel oral anticoagulants after acute coronary syndromes." Cardiovasc Drugs Ther 26, no. 3 (June 2012): 265-271. (Review) Full Text Link to Item
  - Vavalle, JP, and Alexander, JH. "Authors' reply to "the not so 'ideal' body weight-based dosing of Integrilin in obesity"." American Heart Journal 163, no. 4 (April 1, 2012). (Letter) Full Text
  - Al-Khatib, SM, Alexander, JH, Lopes, RD, Mahaffey, KW, Patel, MR, and Granger, CB. "Promise of factor Xa inhibition in atrial fibrillation." Curr Cardiol Rep 14, no. 1 (February 2012): 70-78. (Review) Full Text Link to Item
  - Lopes, RD, Mehta, RH, Hafley, GE, Williams, JB, Mack, MJ, Peterson, ED, Allen, KB, Harrington, RA, Gibson, CM, Califf, RM, Kouchoukos, NT, Ferguson, TB, Alexander, JH, and Project of Ex Vivo Vein Graft Engineering via Transfection IV (PREVENT IV) Investigators, . "Relationship between vein graft failure and subsequent clinical outcomes after coronary artery bypass surgery." Circulation 125, no. 6 (February 2012): 749-756. Full Text
  - Mehta, RH, Stebbins, AS, Lopes, RD, Califf, RM, Pieper, KS, Armstrong, PW, Van de Werf, F, Hochman, JS, White, HD, Topol, EJ, Alexander, JH, and Granger, CB. "Comparison of incidence of bleeding and mortality of men versus women with ST-elevation myocardial infarction treated with fibrinolysis." The American Journal of Cardiology 109, no. 3 (February 2012): 320-326. Full Text
  - Herrmann, HC, Gertz, ZM, Silvestry, FE, Wiegers, SE, Woo, YJ, Hermiller, J, Segar, D, Heimansohn, D, Gray, W, Homma, S, Argenziano, M, Wang, A, Jollis, J, Lampert, MB, Alexander, J, Mauri, L, Foster, E, Glower, D, and Feldman, T. "Effects of atrial fibrillation on treatment of mitral regurgitation in the EVEREST II (Endovascular valve edge-to-edge repair study) randomized trial." Journal of the American College of Cardiology 59, no. 14 (2012): 1312-1319. Full Text
  - Koshizaka, M, Green, JB, and Alexander, JH. "Glycemic management in diabetes and the associated cardiovascular risk: are we helping or hurting our patients?." Circ J 76, no. 7 (2012): 1572-1580. (Review) Link to Item
  - Smith, PK, Michler, RE, Woo, YJ, Alexander, JH, Puskas, JD, Parides, MK, Hahn, RT, Williams, JB, Dent, JM, Ferguson, TB, Moquete, E, Rose, EA, Pagé, P, Jeffries, NO, O'Gara, PT, and Ascheim, DD. "Design, rationale, and initiation of the Surgical Interventions for Moderate Ischemic Mitral Regurgitation Trial: a report from the Cardiothoracic Surgical Trials Network." The Journal of thoracic and cardiovascular surgery 143, no. 1 (January 2012): 111-117.e1. Full Text
  - Vavalle, JP, Stevens, SR, Hassinger, N, Cohen, MG, Arnold, A, Kandzari, DE, Aguirre, FV, Gretler, DD, and Alexander, JH. "The kinetics of integrilin limited by obesity: a multicenter randomized pharmacokinetic and pharmacodynamic clinical trial." American Heart Journal 162, no. 6 (December 2011): 996-1002. Full Text
  - Povsic, TJ, O'Connor, CM, Henry, T, Taussig, A, Kereiakes, DJ, Fortuin, FD, Niederman, A, Schatz, R, Spencer, R, Owens, D, Banks, M, Joseph, D, Roberts, R, Alexander, JH, and Sherman, W. "A double-blind, randomized, controlled, multicenter study to assess the safety and cardiovascular effects of skeletal myoblast implantation by catheter delivery in patients with chronic heart failure after myocardial infarction." American Heart Journal 162, no. 4 (October 2011): 654-662.e1. Full Text
  - Povsic, TJ, Wargin, WA, Alexander, JH, Krasnow, J, Krolick, M, Cohen, MG, Mehran, R, Buller, CE, Bode, C, Zelenkofske, SL, Rusconi, CP, Becker, RC, and RADAR Investigators, . "Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy." Eur Heart J 32, no. 19 (October 2011): 2412-2419. Full Text Link to Item
  - Granger, CB, Alexander, JH, McMurray, JJV, Lopes, RD, Hylek, EM, Hanna, M, Al-Khalidi, HR, Ansell, J, Atar, D, Avezum, A, Bahit, MC, Diaz, R, Easton, JD, Ezekowitz, JA, Flaker, G, Garcia, D, Geraldes, M, Gersh, BJ, Golitsyn, S, Goto, S, Hermosillo, AG, Hohnloser, SH, Horowitz, J, Mohan, P, Jansky, P, Lewis, BS, Lopez-Sendon, JL, Pais, P, Parkhomenko, A, Verheugt, FWA, Zhu, J, Wallentin, L, and ARISTOTLE Committees and Investigators, . "Apixaban versus warfarin in patients with atrial fibrillation." The New England Journal of Medicine 365, no. 11 (September 2011): 981-992. Full Text
  - Lobato, RL, White, WD, Mathew, JP, Newman, MF, Smith, PK, McCants, CB, Alexander, JH, Podgoreanu, MV, and Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team, . "Thrombomodulin gene variants are associated with increased mortality after coronary artery bypass surgery in replicated analyses." Circulation 124, no. 11 Suppl (September 2011): S143-S148. Full Text
  - Saito, S, Prpic, R, Popma, JJ, Alexander, J, Krucoff, MW, and ENDEAVOR Japan Investigators, . "The clinical evaluation of the Endeavor zotarolimus-eluting coronary stent in Japanese patients with de novo native coronary artery lesions: primary results and 3-year follow-up of the Endeavor Japan study." Cardiovascular Revascularization Medicine : Including Molecular Interventions 12, no. 5 (September 2011): 273-279. Full Text
  - Alexander, JH, Lopes, RD, James, S, Kilaru, R, He, Y, Mohan, P, Bhatt, DL, Goodman, S, Verheugt, FW, Flather, M, Huber, K, Liaw, D, Husted, SE, Lopez-Sendon, J, De Caterina, R, Jansky, P, Darius, H, Vinereanu, D, Cornel, JH, Cools, F, Atar, D, Leiva-Pons, JL, Keltai, M, Ogawa, H, Pais, P, Parkhomenko, A, Ruzyllo, W, Diaz, R, White, H, Ruda, M, Geraldes, M, Lawrence, J, Harrington, RA, Wallentin, L, and APPRAISE-2 Investigators, . "Apixaban with antiplatelet therapy after acute coronary syndrome." The New England Journal of Medicine 365, no. 8 (August 2011): 699-708. Full Text
  - Becker, RC, Yang, H, Barrett, Y, Mohan, P, Wang, J, Wallentin, L, and Alexander, JH. "Chromogenic laboratory assays to measure the factor Xa-inhibiting properties of apixaban--an oral, direct and selective factor Xa inhibitor." Journal of Thrombosis and Thrombolysis 32, no. 2 (August 2011): 183-187. Full Text
  - Lopes, RD, Becker, RC, Alexander, JH, Armstrong, PW, Califf, RM, Chan, MY, Crowther, M, Granger, CB, Harrington, RA, Hylek, EM, James, SK, Jolicoeur, EM, Mahaffey, KW, Newby, LK, Peterson, ED, Pieper, KS, Van de Werf, F, Wallentin, L, White, HD, Carvalho, AC, Giraldez, RR, Guimaraes, HP, Nader, HB, Kalil, RAK, Bizzachi, JMA, Lopes, AC, and Garcia, DA. "Highlights from the III International Symposium of Thrombosis and Anticoagulation (ISTA), October 14-16, 2010, São Paulo, Brazil." Journal of Thrombosis and Thrombolysis 32, no. 2 (August 2011): 242-266. Full Text
  - Mehta, RH, Ferguson, TB, Lopes, RD, Hafley, GE, Mack, MJ, Kouchoukos, NT, Gibson, CM, Harrington, RA, Califf, RM, Peterson, ED, Alexander, JH, and Project of Ex-vivo Vein Graft Engineering via Transfection (PREVENT) IV Investigators, . "Saphenous vein grafts with multiple versus single distal targets in patients undergoing coronary artery bypass surgery: one-year graft failure and five-year outcomes from the Project of Ex-Vivo Vein Graft Engineering via Transfection (PREVENT) IV trial." Circulation 124, no. 3 (July 2011): 280-288. Full Text
  - Povsic, TJ, Cohen, MG, Chan, MY, Zelenkofske, SL, Wargin, WA, Harrington, RA, Alexander, JH, Rusconi, CP, and Becker, RC. "Dose selection for a direct and selective factor IXa inhibitor and its complementary reversal agent: translating pharmacokinetic and pharmacodynamic properties of the REG1 system to clinical trial design." J Thromb Thrombolysis 32, no. 1 (July 2011): 21-31. Full Text Link to Item
  - Leiria, TLL, Lopes, RD, Williams, JB, Katz, JN, Kalil, RAK, and Alexander, JH. "Antithrombotic therapies in patients with prosthetic heart valves: guidelines translated for the clinician." Journal of thrombosis and thrombolysis 31, no. 4 (May 2011): 514-522. (Review) Full Text
  - Domanski, MJ, Mahaffey, K, Hasselblad, V, Brener, SJ, Smith, PK, Hillis, G, Engoren, M, Alexander, JH, Levy, JH, Chaitman, BR, Broderick, S, Mack, MJ, Pieper, KS, and Farkouh, ME. "Association of myocardial enzyme elevation and survival following coronary artery bypass graft surgery." Jama 305, no. 6 (February 2011): 585-591. Full Text
  - Povsic, TJ, Cohen, MG, Mehran, R, Buller, CE, Bode, C, Cornel, JH, Kasprzak, JD, Montalescot, G, Joseph, D, Wargin, WA, Rusconi, CP, Zelenkofske, SL, Becker, RC, and Alexander, JH. "A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: design and rationale of the RADAR Phase IIb trial." Am Heart J 161, no. 2 (February 2011): 261-268.e1-2-. Full Text Link to Item
  - Alexander, J. "SY06-5 Apixaban for the Prevention of Thromboembolic Events in Patients with Atrial Fibrillation: Primary Results of the ARISTOTLE Trial." Journal of Arrhythmia 27 (January 1, 2011). Full Text
  - Alexander, JH, Lopes, RD, and Wallentin, L. "The authors reply." New England Journal of Medicine 365, no. 19 (2011): 1844-1845. Full Text
  - Mehta, RH, Stebbins, A, Lopes, RD, Rao, SV, Bates, ER, Pieper, KS, Armstrong, PW, Van de Werf, F, White, HD, Califf, RM, Alexander, JH, and Granger, CB. "Race, Bleeding, and Outcomes in STEMI Patients Treated with Fibrinolytic Therapy." The American Journal of Medicine 124, no. 1 (January 2011): 48-57. Full Text
  - Piccini, JP, Schulte, PJ, Pieper, KS, Mehta, RH, White, HD, Van de Werf, F, Ardissino, D, Califf, RM, Granger, CB, Ohman, EM, and Alexander, JH. "Antiarrhythmic drug therapy for sustained ventricular arrhythmias complicating acute myocardial infarction." Critical Care Medicine 39, no. 1 (January 2011): 78-83. Full Text
  - Povsic, TJ, Cohen, MG, Chan, MY, Zelenkofske, SL, Wargin, WA, Harrington, RA, Alexander, JH, Rusconi, CP, and Becker, RC. "Dose Selection for a Direct and Selective Factor IXa Inhibitor and its Complementary Reversal Agent: Translating Pharmacokinetic and Pharmacodynamic Properties of the REG1 System to Clinical Trial Design." Journal of Thrombosis and Thrombolysis (2011): 1-11. Full Text
  - Stashenko, G, Lopes, RD, Garcia, D, Alexander, JH, and Tapson, VF. "Prophylaxis for venous thromboembolism: guidelines translated for the clinician." J Thromb Thrombolysis 31, no. 1 (January 2011): 122-132. (Review) Full Text Link to Item
  - Becker, RC, Alexander, JH, Newby, LK, Yang, H, Barrett, Y, Mohan, P, Wang, J, Harrington, RA, and Wallentin, LC. "Effect of apixaban, an oral and direct factor Xa inhibitor, on coagulation activity biomarkers following acute coronary syndrome." Thromb Haemost 104, no. 5 (November 2010): 976-983. Full Text Link to Item
  - Cohen, MG, Purdy, DA, Rossi, JS, Grinfeld, LR, Myles, SK, Aberle, LH, Greenbaum, AB, Fry, E, Chan, MY, Tonkens, RM, Zelenkofske, S, Alexander, JH, Harrington, RA, Rusconi, CP, and Becker, RC. "First clinical application of an actively reversible direct factor IXa inhibitor as an anticoagulation strategy in patients undergoing percutaneous coronary intervention." Circulation 122, no. 6 (August 2010): 614-622. Full Text
  - Frederich, R, Alexander, JH, Fiedorek, FT, Donovan, M, Berglind, N, Harris, S, Chen, R, Wolf, R, and Mahaffey, KW. "A systematic assessment of cardiovascular outcomes in the saxagliptin drug development program for type 2 diabetes." Postgraduate Medicine 122, no. 3 (May 2010): 16-27. Full Text
  - Gharacholou, SM, Lopes, RD, Washam, JB, Newby, LK, James, SK, and Alexander, JH. "Antithrombotic therapy in acute coronary syndromes: guidelines translated for the clinician." J Thromb Thrombolysis 29, no. 4 (May 2010): 516-528. (Review) Full Text Link to Item
  - Lopes, RD, Garcia, D, Becker, RC, Granger, CB, Newby, LK, Alexander, JH, Jolicoeur, EM, Handler, A, Pieper, KS, Carvalho, AC, Guimaraes, HP, Chamone, DAF, Baruzzi, AC, Machado, FS, Timerman, A, and Lopes, AC. "Highlights from the II International Symposium of Thrombosis and Anticoagulation (ISTA), October 22-23, 2009, São Paulo, Brazil." J Thromb Thrombolysis 29, no. 4 (May 2010): 395-408. Full Text Link to Item
  - Rao, SV, Melloni, C, Myles-Dimauro, S, Broderick, S, Kosinski, AS, Kleiman, NS, Dzavík, V, Tanguay, JF, Chandna, H, Gammon, R, Rivera, E, Alexander, JH, Fier, I, Roach, J, Becker, RC, and EMINENCE Investigators, . "Evaluation of a new heparin agent in percutaneous coronary intervention: results of the phase 2 evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) Trial." Circulation 121, no. 15 (April 5, 2010): 1713-1721. Full Text
  - Krishnan, A, Lopes, RD, Alexander, JH, Becker, RC, and Goldstein, LB. "Antithrombotic therapy for ischemic stroke: guidelines translated for the clinician." J Thromb Thrombolysis 29, no. 3 (April 2010): 368-377. (Review) Full Text Link to Item
  - Lopes, RD, Alexander, JH, Al-Khatib, SM, Ansell, J, Diaz, R, Easton, JD, Gersh, BJ, Granger, CB, Hanna, M, Horowitz, J, Hylek, EM, McMurray, JJV, Verheugt, FWA, Wallentin, L, and ARISTOTLE Investigators, . "Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: design and rationale." American Heart Journal 159, no. 3 (March 2010): 331-339. Full Text
  - Lopes, RD, Alexander, JH, and Ferguson, TB. "The authors reply." New England Journal of Medicine 361, no. 19 (November 5, 2009): 1909-1910. (Letter) Open Access Copy
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  - Houman Fekrazad, M, Lopes, RD, Stashenko, GJ, Alexander, JH, and Garcia, D. "Treatment of venous thromboembolism: guidelines translated for the clinician." J Thromb Thrombolysis 28, no. 3 (October 2009): 270-275. Full Text Link to Item
  - Kraai, EP, Lopes, RD, Alexander, JH, and Garcia, D. "Perioperative management of anticoagulation: guidelines translated for the clinician." J Thromb Thrombolysis 28, no. 1 (July 2009): 16-22. (Review) Full Text Link to Item
  - Lopes, RD, Hafley, GE, Allen, KB, Ferguson, TB, Peterson, ED, Harrington, RA, Mehta, RH, Gibson, CM, Mack, MJ, Kouchoukos, NT, Califf, RM, and Alexander, JH. "Endoscopic versus open vein-graft harvesting in coronary-artery bypass surgery." The New England Journal of Medicine 361, no. 3 (July 2009): 235-244. Full Text
  - APPRAISE Steering Committee and Investigators, , Alexander, JH, Becker, RC, Bhatt, DL, Cools, F, Crea, F, Dellborg, M, Fox, KAA, Goodman, SG, Harrington, RA, Huber, K, Husted, S, Lewis, BS, Lopez-Sendon, J, Mohan, P, Montalescot, G, Ruda, M, Ruzyllo, W, Verheugt, F, and Wallentin, L. "Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial." Circulation 119, no. 22 (June 2009): 2877-2885. Full Text
  - Turer, AT, Mahaffey, KW, Honeycutt, E, Tuttle, RH, Shaw, LK, Sketch, MH, Smith, PK, Califf, RM, and Alexander, JH. "Influence of body mass index on the efficacy of revascularization in patients with coronary artery disease." The Journal of Thoracic and Cardiovascular Surgery 137, no. 6 (June 2009): 1468-1474. Full Text
  - Alexander, JH. "The current state of antiplatelet therapy in acute coronary syndromes: The data and the real world." Cleveland Clinic Journal of Medicine 76, no. SUPPL.1 (2009): S16-S23. Full Text
  - Bhatt, DL, Kottke-Marchant, K, Alexander, JH, Peacock, WF, and Sabatine, MS. "Platelet response in practice: Applying new insights and tools for testing and treatment." Cleveland Clinic Journal of Medicine 76, no. SUPPL.1 (2009): S24-S32. Full Text
  - Katz, JN, Stebbins, AL, Alexander, JH, Reynolds, HR, Pieper, KS, Ruzyllo, W, Werdan, K, Geppert, A, Dzavik, V, Werf, FVD, and Hochman, JS. "Predictors of 30-day mortality in patients with refractory cardiogenic shock following acute myocardial infarction despite a patent infarct artery." American Heart Journal 158, no. 4 (2009): 680-687. Full Text
  - Lopes, RD, Piccini, JP, Hylek, EM, Granger, CB, and Alexander, JH. "Antithrombotic therapy in atrial fibrillation: guidelines translated for the clinician." J Thromb Thrombolysis 26, no. 3 (December 2008): 167-174. (Review) Full Text Link to Item
  - Mehta, RH, Hafley, GE, Gibson, CM, Harrington, RA, Peterson, ED, Mack, MJ, Kouchoukos, NT, Califf, RM, Ferguson, TB, Alexander, JH, and Project of Ex-vivo Vein Graft Engineering via Transfection (PREVENT)-IV Investigators, . "Influence of preoperative renal dysfunction on one-year bypass graft patency and two-year outcomes in patients undergoing coronary artery bypass surgery." The Journal of Thoracic and Cardiovascular Surgery 136, no. 5 (November 2008): 1149-1155. Full Text
  - Alexander, JH, Ellis, SJ, and Tardif, JC. "In reply." Jama Journal of the American Medical Association 300, no. 9 (September 3, 2008): 1021-1022. (Letter) Full Text
  - Yau, JM, Alexander, JH, Hafley, G, Mahaffey, KW, Mack, MJ, Kouchoukos, N, Goyal, A, Peterson, ED, Gibson, CM, Califf, RM, Harrington, RA, Ferguson, TB, and PREVENT IV Investigators, . "Impact of perioperative myocardial infarction on angiographic and clinical outcomes following coronary artery bypass grafting (from PRoject of Ex-vivo Vein graft ENgineering via Transfection [PREVENT] IV)." The American Journal of Cardiology 102, no. 5 (September 2008): 546-551. Full Text
  - Chan, MY, Cohen, MG, Dyke, CK, Myles, SK, Aberle, LG, Lin, M, Walder, J, Steinhubl, SR, Gilchrist, IC, Kleiman, NS, Vorchheimer, DA, Chronos, N, Melloni, C, Alexander, JH, Harrington, RA, Tonkens, RM, Becker, RC, and Rusconi, CP. "Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease." Circulation 117, no. 22 (June 2008): 2865-2874. Full Text
  - Chan, MY, Rusconi, CP, Alexander, JH, Tonkens, RM, Harrington, RA, and Becker, RC. "A randomized, repeat-dose, pharmacodynamic and safety study of an antidote-controlled factor IXa inhibitor." J Thromb Haemost 6, no. 5 (May 2008): 789-796. Full Text Link to Item
  - MEND-CABG II Investigators, , Alexander, JH, Emery, RW, Carrier, M, Ellis, SJ, Mehta, RH, Hasselblad, V, Menasche, P, Khalil, A, Cote, R, Bennett-Guerrero, E, Mack, MJ, Schuler, G, Harrington, RA, and Tardif, J-C. "Efficacy and safety of pyridoxal 5'-phosphate (MC-1) in high-risk patients undergoing coronary artery bypass graft surgery: the MEND-CABG II randomized clinical trial." Jama 299, no. 15 (April 2008): 1777-1787. Full Text
  - Mehta, RH, Alexander, JH, Emery, R, Ellis, SJ, Hasselblad, V, Khalil, A, Carrier, M, Harrington, RA, Tardif, J-C, and MEND-CABG II Investigators, . "A randomized, double-blind, placebo-controlled, multicenter study to evaluate the cardioprotective effects of MC-1 in patients undergoing high-risk coronary artery bypass graft surgery: MC-1 to Eliminate Necrosis and Damage in Coronary Artery Bypass Graft Surgery Trial (MEND-CABG) II--study design and rationale." Am Heart J 155, no. 4 (April 2008): 600-608. Full Text Link to Item
  - Magee, MJ, Alexander, JH, Hafley, G, Ferguson, TB, Gibson, CM, Harrington, RA, Peterson, ED, Califf, RM, Kouchoukos, NT, Herbert, MA, Mack, MJ, and PREVENT IV Investigators, . "Coronary artery bypass graft failure after on-pump and off-pump coronary artery bypass: findings from PREVENT IV." The Annals of Thoracic Surgery 85, no. 2 (February 2008): 494-499. Full Text
  - Olenchock, SA, Karmpaliotis, D, Gibson, WJ, Murphy, SA, Southard, MC, Ciaglo, L, Buros, J, Mack, MJ, Alexander, JH, Harrington, RA, Califf, RM, Kouchoukos, NT, Ferguson, TB, and Gibson, CM. "Impact of saphenous vein graft radiographic markers on clinical events and angiographic parameters." The Annals of Thoracic Surgery 85, no. 2 (February 2008): 520-524. Full Text
  - Harrington, RA, Alexander, JH, Hochman, JS, Reynolds, HR, Dzavik, V, and Van De Werf, FJ. "Tilarginine in patients with acute myocardial infarction and cardiogenic shock - In reply [7]." Journal of the American Medical Association 298, no. 9 (September 5, 2007): 972-973. (Letter) Full Text
  - Cohen, M, Bhatt, DL, Alexander, JH, Montalescot, G, Bode, C, Henry, T, Tamby, J-F, Saaiman, J, Simek, S, De Swart, J, and SEPIA-PCI Trial Investigators, . "Randomized, double-blind, dose-ranging study of otamixaban, a novel, parenteral, short-acting direct factor Xa inhibitor, in percutaneous coronary intervention: the SEPIA-PCI trial." Circulation 115, no. 20 (May 22, 2007): 2642-2651. Full Text Link to Item
  - Dzavík, V, Cotter, G, Reynolds, HR, Alexander, JH, Ramanathan, K, Stebbins, AL, Hathaway, D, Farkouh, ME, Ohman, EM, Baran, DA, Prondzinsky, R, Panza, JA, Cantor, WJ, Vered, Z, Buller, CE, Kleiman, NS, Webb, JG, Holmes, DR, Parrillo, JE, Hazen, SL, Gross, SS, Harrington, RA, Hochman, JS, and SHould we inhibit nitric Oxide synthase in Cardiogenic shocK 2 (SHOCK-2) investigators, . "Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study." Eur Heart J 28, no. 9 (May 2007): 1109-1116. Full Text Link to Item
  - TRIUMPH Investigators, , Alexander, JH, Reynolds, HR, Stebbins, AL, Dzavik, V, Harrington, RA, Van de Werf, F, and Hochman, JS. "Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial." Jama 297, no. 15 (April 2007): 1657-1666. Full Text
  - Gheorghiade, M, Konstam, MA, Burnett, JC, Grinfeld, L, Maggioni, AP, Swedberg, K, Udelson, JE, Zannad, F, Cook, T, Ouyang, J, Zimmer, C, Orlandi, C, and Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan (EVEREST) Investigators, . "Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials." Jama 297, no. 12 (March 25, 2007): 1332-1343. Full Text
  - Goyal, A, Alexander, JH, Hafley, GE, Graham, SH, Mehta, RH, Mack, MJ, Wolf, RK, Cohn, LH, Kouchoukos, NT, Harrington, RA, Gennevois, D, Gibson, CM, Califf, RM, Ferguson, TB, Peterson, ED, and PREVENT IV Investigators, . "Outcomes associated with the use of secondary prevention medications after coronary artery bypass graft surgery." The Annals of Thoracic Surgery 83, no. 3 (March 2007): 993-1001. Full Text
  - Mahaffey, KW, Roe, MT, Kilaru, R, Alexander, JH, Van de Werf, F, Califf, RM, Simoons, ML, Topol, EJ, and Harrington, RA. "Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials." European Heart Journal 28, no. 4 (February 2007): 425-432. Full Text
  - Dyke, CK, Steinhubl, SR, Kleiman, NS, Cannon, RO, Aberle, LG, Lin, M, Myles, SK, Melloni, C, Harrington, RA, Alexander, JH, Becker, RC, and Rusconi, CP. "First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity." Circulation 114, no. 23 (December 2006): 2490-2497. Full Text
  - Madsen, LH, Christensen, G, Lund, T, Serebruany, VL, Granger, CB, Hoen, I, Grieg, Z, Alexander, JH, Jaffe, AS, Van Eyk, JE, and Atar, D. "Time course of degradation of cardiac troponin I in patients with acute ST-elevation myocardial infarction: the ASSENT-2 troponin substudy." Circulation Research 99, no. 10 (November 2006): 1141-1147. Full Text
  - Alexander, JH, and Harrington, RA. "Advances in antithrombotic therapy in acute myocardial infarction: the ExTRACT-TIMI 25 and OASIS-6 Trials." Current Cardiology Reports 8, no. 4 (July 2006): 279-281. Full Text
  - Alexander, JH, Harrington, RA, Ferguson, TB, Peterson, ED, Gibson, CM, and Kouchoukos, NT. "In reply [4]." Journal of the American Medical Association 295, no. 13 (April 5, 2006): 1514-1515. (Letter) Full Text
  - Becker, RC, Alexander, JH, Dyke, C, Huang, Y, Saint-Jacques, H, Hasselblad, V, Harrington, RA, Bovill, EG, and XaNADU-1B Investigators, . "Effect of the novel direct factor Xa inhibitor DX-9065a on thrombin generation and inhibition among patients with stable atherosclerotic coronary artery disease." Thrombosis Research 117, no. 4 (January 2006): 439-446. Full Text
  - Galla, JM, Mahaffey, KW, Sapp, SK, Alexander, JH, Roe, MT, Ohman, EM, Granger, CB, Armstrong, PW, Harrington, RA, White, HD, Simoons, ML, Newby, LK, Califf, RM, and Topol, EJ. "Elevated creatine kinase-MB with normal creatine kinase predicts worse outcomes in patients with acute coronary syndromes: results from 4 large clinical trials." American Heart Journal 151, no. 1 (January 2006): 16-24. Full Text
  - Alexander, JH, Hafley, G, Harrington, RA, Peterson, ED, Ferguson, TB, Lorenz, TJ, Goyal, A, Gibson, M, Mack, MJ, Gennevois, D, Califf, RM, Kouchoukos, NT, and PREVENT IV Investigators, . "Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial." Jama 294, no. 19 (November 2005): 2446-2454. Full Text
  - Halabi, AR, Alexander, JH, Shaw, LK, Lorenz, TJ, Liao, L, Kong, DF, Milano, CA, Harrington, RA, and Smith, PK. "Relation of early saphenous vein graft failure to outcomes following coronary artery bypass surgery." The American Journal of Cardiology 96, no. 9 (November 2005): 1254-1259. Full Text
  - Alexander, JH, Ferguson, TB, Joseph, DM, Mack, MJ, Wolf, RK, Gibson, CM, Gennevois, D, Lorenz, TJ, Harrington, RA, Peterson, ED, Lee, KL, Califf, RM, Kouchoukos, NT, and PREVENT IV Investigators, . "The PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) trial: study rationale, design, and baseline patient characteristics." American Heart Journal 150, no. 4 (October 2005): 643-649. Full Text
  - Mahaffey, KW, Roe, MT, Kilaru, R, French, JK, Alexander, JH, Berdan, LG, Van De Werf, F, Simoons, ML, Weaver, WD, White, HD, Lincoff, AM, Kleiman, NS, Topol, EJ, and Harrington, RA. "Characterization of myocardial infarction as an end point in two large trials of acute coronary syndromes." Am J Cardiol 95, no. 12 (June 15, 2005): 1404-1408. Full Text Link to Item
  - Mehta, RH, Califf, RM, Garg, J, Pieper, KS, Alexander, JH, Moliterno, DJ, Van de Werf, F, Ohman, EM, White, HD, Topol, EJ, and Granger, CB. "Association of height with outcomes in patients with acute myocardial infarction receiving reperfusion therapy." The American Journal of Cardiology 95, no. 11 (June 2005): 1371-1375. Full Text
  - Mehta, RH, Alexander, JH, Van de Werf, F, Armstrong, PW, Pieper, KS, Garg, J, Califf, RM, and Granger, CB. "Relationship of incorrect dosing of fibrinolytic therapy and clinical outcomes." Jama 293, no. 14 (April 2005): 1746-1750. Full Text
  - Meine, TJ, Al-Khatib, SM, Alexander, JH, Granger, CB, White, HD, Kilaru, R, Williams, K, Ohman, EM, Topol, E, and Califf, RM. "Incidence, predictors, and outcomes of high-degree atrioventricular block complicating acute myocardial infarction treated with thrombolytic therapy." American Heart Journal 149, no. 4 (April 2005): 670-674. Full Text
  - Alexander, JH, Yang, H, Becker, RC, Kodama, K, Goodman, S, Dyke, CK, Kleiman, NS, Hochman, JS, Berger, PB, Cohen, EA, Lincoff, AM, Burton, JR, Bovill, EG, Kawai, C, Armstrong, PW, Harrington, RA, and XaNADU-ACS INVESTIGATORS, . "First experience with direct, selective factor Xa inhibition in patients with non-ST-elevation acute coronary syndromes: results of the XaNADU-ACS Trial." J Thromb Haemost 3, no. 3 (March 2005): 439-447. Full Text Link to Item
  - Alexander, JH, and Singh, KP. "Inhibition of Factor Xa : a potential target for the development of new anticoagulants." American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions 5, no. 5 (January 2005): 279-290. (Review) Full Text
  - Borges-Neto, S, Shaw, LK, Tuttle, RH, Alexander, JH, Smith, WT, Chambless, M, Coleman, RE, Harrington, RA, and Califf, RM. "Incremental prognostic power of single-photon emission computed tomographic myocardial perfusion imaging in patients with known or suspected coronary artery disease." The American Journal of Cardiology 95, no. 2 (January 2005): 182-188. Full Text
  - Becker, RC, Alexander, J, Dyke, CK, and Harrington, RA. "Development of DX-9065a, a novel direct factor Xa antagonist, in cardiovascular disease." Thrombosis and Haemostasis 92, no. 6 (December 2004): 1182-1193. (Review) Full Text
  - Becker, RC, Alexander, JH, Li, Y, Robertson, T, Kunitada, S, Spencer, FA, Yang, H, and Harrington, RA. "Vascular endothelial tissue factor pathway inhibitor kinetics in culture following exposure to DX-9065a--a selective and direct factor Xa inhibitor." J Thromb Thrombolysis 18, no. 3 (December 2004): 193-197. Full Text Link to Item
  - Weston, P, Alexander, JH, Patel, MR, Maynard, C, Crawford, L, and Wagner, GS. "Hand-held echocardiographic examination of patients with symptoms of acute coronary syndromes in the emergency department: the 30-day outcome associated with normal left ventricular wall motion." Am Heart J 148, no. 6 (December 2004): 1096-1101. Full Text Link to Item
  - Bethel, MA, Alexander, J, Lane, J, Barkauskas, C, and Feinglos, MN. "Diabetes on a cardiovascular ward: adherence to current recommendations." South Med J 97, no. 11 (November 2004): 1031-1037. Full Text Link to Item
  - Curtis, JP, Alexander, JH, Huang, Y, Wallentin, L, Verheugt, FWA, Armstrong, PW, Krumholz, HM, Van de Werf, F, Danays, T, Cheeks, M, Granger, CB, and ASSENT-2 and ASSENT-3 Investigators, . "Efficacy and safety of two unfractionated heparin dosing strategies with tenecteplase in acute myocardial infarction (results from Assessment of the Safety and Efficacy of a New Thrombolytic Regimens 2 and 3)." The American Journal of Cardiology 94, no. 3 (August 2004): 279-283. Full Text
  - Sinnaeve, PR, Alexander, JH, Bogaerts, K, Belmans, A, Wallentin, L, Armstrong, P, Adgey, JAA, Tendera, M, Diaz, R, Soares-Piegas, L, Vahanian, A, Granger, CB, and Van De Werf, FJ. "Efficacy of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: one-year follow-up results of the Assessment of the Safety of a New Thrombolytic-3 (ASSENT-3) randomized trial in acute myocardial infarction." American Heart Journal 147, no. 6 (June 2004): 993-998. Full Text
  - Waters, RE, Singh, KP, Roe, MT, Lotfi, M, Sketch, MH, Mahaffey, KW, Newby, LK, Alexander, JH, Harrington, RA, Califf, RM, and Granger, CB. "Rationale and strategies for implementing community-based transfer protocols for primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction." Journal of the American College of Cardiology 43, no. 12 (June 2004): 2153-2159. (Review) Full Text
  - Alexander, JH, Peterson, ED, Chen, AY, Harding, TM, Adams, DB, and Kisslo, JA. "Feasibility of point-of-care echocardiography by internal medicine house staff." American Heart Journal 147, no. 3 (March 2004): 476-481. Full Text
  - Alexander, JH, Dyke, CK, Yang, H, Becker, RC, Hasselblad, V, Zillman, LA, Kleiman, NS, Hochman, JS, Berger, PB, Cohen, EA, Lincoff, AM, Saint-Jacques, H, Chetcuti, S, Burton, JR, Buergler, JM, Spence, FP, Shimoto, Y, Robertson, TL, Kunitada, S, Bovill, EG, Armstrong, PW, Harrington, RA, and XaNADU-PCI PILOT Investigators, . "Initial experience with factor-Xa inhibition in percutaneous coronary intervention: the XaNADU-PCI Pilot." J Thromb Haemost 2, no. 2 (February 2004): 234-241. Link to Item
  - Alexander, JH. "Clinical trials in Japan and the United States." American Heart Journal 147, no. 2 (February 2004): 200-201. Full Text
  - Roe, MT, Mahaffey, KW, Kilaru, R, Alexander, JH, Akkerhuis, KM, Simoons, ML, Harrington, RA, Tardiff, BE, Granger, CB, Ohman, EM, Moliterno, DJ, Lincoff, AM, Armstrong, PW, Van de Werf, F, Califf, RM, and Topol, EJ. "Creatine kinase-MB elevation after percutaneous coronary intervention predicts adverse outcomes in patients with acute coronary syndromes." European Heart Journal 25, no. 4 (February 2004): 313-321. Full Text
  - Becker, RC, Alexander, J, Li, YF, Bovill, E, Spencer, FA, Robertson, TL, Kunitada, S, Dyke, CK, and Harrington, RA. "Combined coagulation phase-directed factor Xa inhibition with heparin compounds and DX-9065a - A direct and selective antagonist [1]." Thrombosis and Haemostasis 92, no. 6 (2004): 1229-1231.
  - Rebeiz, AG, Roe, MT, Alexander, JH, Mahaffey, KW, Granger, CB, Peterson, ED, Califf, RM, and Harrington, RA. "Integrating antithrombin and antiplatelet therapies with early invasive management for non-ST-segment elevation acute coronary syndromes." The American Journal of Medicine 116, no. 2 (January 2004): 119-129. (Review) Full Text
  - Alexander, JH, Harrington, RA, Bhapkar, M, Mahaffey, KW, Lincoff, AM, Ohman, EM, Klootwijk, P, Pahlm, O, Henden, B, Deckers, JW, Simoons, ML, Califf, RM, and Wagner, GS. "Prognostic importance of new small Q waves following non-ST-elevation acute coronary syndromes." The American Journal of Medicine 115, no. 8 (December 2003): 613-619. Full Text
  - Alexander, JH, and Patel, MR. "Screening for structural heart disease: time to stop listening and start looking." Am Heart J 146, no. 4 (October 2003): 570-571. Full Text Link to Item
  - Sinnaeve, P, Alexander, J, Belmans, A, Bogaerts, K, Langer, A, Diaz, R, Ardissino, D, Vahanian, A, Pehrsson, K, Armstrong, P, Van de Werf, F, and ASSENT-2 Investigators, . "One-year follow-up of the ASSENT-2 trial: a double-blind, randomized comparison of single-bolus tenecteplase and front-loaded alteplase in 16,949 patients with ST-elevation acute myocardial infarction." American Heart Journal 146, no. 1 (July 2003): 27-32. Full Text
  - Serebruany, VL, Malinin, AI, Callahan, KP, Binbrek, A, Van De Werf, F, Alexander, JH, Granger, CB, Gurbel, PA, and Assessment of the Safety and Efficacy of a New Thrombolytic Agent platelet substudy, . "Effect of tenecteplase versus alteplase on platelets during the first 3 hours of treatment for acute myocardial infarction: the Assessment of the Safety and Efficacy of a New Thrombolytic Agent (ASSENT-2) platelet substudy." American Heart Journal 145, no. 4 (April 2003): 636-642. Full Text
  - Akkerhuis, KM, Alexander, JH, Tardiff, BE, Boersma, E, Harrington, RA, Lincoff, AM, and Simoons, ML. "Minor myocardial damage and prognosis: are spontaneous and percutaneous coronary intervention-related events different?." Circulation 105, no. 5 (February 2002): 554-556. Full Text
  - Angeja, BG, Alexander, JH, Chin, R, Li, X, Barron, HV, Armstrong, PW, Granger, CB, Van de Werf, F, and Gibson, CM. "Safety of the weight-adjusted dosing regimen of tenecteplase in the ASSENT-Trial." The American Journal of Cardiology 88, no. 11 (December 2001): 1240-1245. Full Text
  - Callahan, KP, Malinin, AI, Gurbel, PA, Alexander, JH, Granger, CB, Atar, D, and Serebruany, VL. "Platelets and thrombolysis: Cooperation or contrariety?." Heartdrug 1, no. 5 (December 1, 2001): 281-290. (Review) Full Text
  - Daniels, SR. "Short-term trials and long-term effects." Science (New York, N.Y.) 293, no. 5539 (September 2001): 2392-2394. (Letter) Full Text
  - Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 Investigators, . "Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction." Lancet (London, England) 358, no. 9282 (August 2001): 605-613. Full Text
  - Al-Khatib, SM, Califf, RM, Hasselblad, V, Alexander, JH, McCrory, DC, and Sugarman, J. "Medecine: Placebo-controls in short-term clinical trials of hypertension." Science 292, no. 5524 (June 15, 2001). Full Text
  - Al-Khatib, SM, Califf, RM, Hasselblad, V, Alexander, JH, McCrory, DC, and Sugarman, J. "Medicine. Placebo-controls in short-term clinical trials of hypertension." Science (New York, N.Y.) 292, no. 5524 (June 2001): 2013-2015. (Review) Full Text
  - Callahan, KP, Malinin, AI, Gurbel, PA, Alexander, JH, Granger, CB, and Serebruany, VL. "Platelet function and fibrinolytic agents: two sides of a coin?." Cardiology 95, no. 2 (January 2001): 55-60. Full Text
  - Alexander, JH, Sparapani, RA, Mahaffey, KW, Deckers, JW, Newby, LK, Ohman, EM, Corbalán, R, Chierchia, SL, Boland, JB, Simoons, ML, Califf, RM, Topol, EJ, and Harrington, RA. "Association between minor elevations of creatine kinase-MB level and mortality in patients with acute coronary syndromes without ST-segment elevation." Journal of the American Medical Association 283, no. 3 (2000): 347-353.
  - McGuire, DK, Hudson, MP, East, MA, Dyke, CK, Cantor, WJ, Battle, J, Bahit, MC, Al-Khatib, SM, and Alexander, JH. "Highlights from the American Heart Association 72nd Scientific Sessions: November 6 to 10, 1999." American Heart Journal 139, no. 2 (January 1, 2000): 359-370. Full Text
  - Patel, M, Han, SS, Vaux, K, Saalfeld, J, and Alexander, JH. "A protocol of early spiral computed tomography for the detection of stones in patients with renal colic has reduced the time to diagnosis and overall management costs." Aust N Z J Surg 70, no. 1 (January 2000): 39-42. Link to Item
  - Alexander, JH, Al-Khatib, S, Cantor, W, Greenbaum, AB, Hudson, MP, Kong, DF, and Shah, M. "Highlights from the American College of Cardiology 48th Annual Scientific Sessions: March 7 to 10, 1999." Am Heart J 138, no. 1 Pt 1 (July 1999): 175-190. Link to Item
  - Pertusi, RM, Godwin, KS, House, JK, Knebl, JA, Alexander, JH, Rubin, BR, and Forman, MD. "Gastropathy induced by nonsteroidal anti-inflammatory drugs: prescribing patterns among geriatric practitioners." J Am Osteopath Assoc 99, no. 6 (June 1999): 305-310. Link to Item
  - Alexander, JH, Granger, CB, Sadowski, Z, Aylward, PE, White, HD, Thompson, TD, Califf, RM, and Topol, EJ. "Prophylactic lidocaine use in acute myocardial infarction: incidence and outcomes from two international trials. The GUSTO-I and GUSTO-IIb Investigators." American Heart Journal 137, no. 5 (May 1999): 799-805. Full Text
  - Eachempati, SR, Young, C, Alexander, J, Cirisano, FD, Rodriguez, GC, and Reed, RL. "The clinical use of an esophageal Doppler monitor for hemodynamic monitoring in sepsis." J Clin Monit Comput 15, no. 3-4 (May 1999): 223-225. Link to Item
  - Sadowski, ZP, Alexander, JH, Skrabucha, B, Dyduszynski, A, Kuch, J, Nartowicz, E, Swiatecka, G, Kong, DF, and Granger, CB. "Multicenter randomized trial and a systematic overview of lidocaine in acute myocardial infarction." Am Heart J 137, no. 5 (May 1999): 792-798. Link to Item
  - Alexander, JH, Harrington, RA, Tuttle, RH, Berdan, LG, Lincoff, AM, Deckers, JW, Simoons, ML, Guerci, A, Hochman, JS, Wilcox, RG, Kitt, MM, Eisenberg, PR, Califf, RM, Topol, EJ, Karsh, K, Ruzyllo, W, Stepinska, J, Widimsky, P, Boland, JB, and Armstrong, PW. "Prior aspirin use predicts worse outcomes in patients with non-ST- elevation acute coronary syndromes." American Journal of Cardiology 83, no. 8 (April 15, 1999): 1147-1151. Full Text
  - Alexander, JH, Harrington, RA, Tuttle, RH, Berdan, LG, Lincoff, AM, Deckers, JW, Simoons, ML, Guerci, A, Hochman, JS, Wilcox, RG, Kitt, MM, Eisenberg, PR, Califf, RM, Topol, EJ, Karsh, K, Ruzyllo, W, Stepinska, J, Widimsky, P, Boland, JB, and Armstrong, PW. "Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes. PURSUIT Investigators. Platelet IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy." The American Journal of Cardiology 83, no. 8 (April 1999): 1147-1151. Full Text
  - Alexander, JH, Kong, DF, and Cantor, WJ. "Highlights from the 71st American Heart Association Scientific Sessions: November 8 to 11, 1998." Am Heart J 137, no. 3 (March 1999): 555-574. Link to Item
  - Alexander, JH, Al-Khatib, S, Cantor, W, Greenbaum, AB, Hudson, MP, Kong, DF, and Shah, M. "Highlights from the American College of Cardiology 48th Annual Scientific Sessions: March 7 to 10, 1999." American Heart Journal 138, no. 1 I (January 1, 1999): 175-190. Full Text
  - Alexander, JH, Granger, CB, Sadowski, Z, Aylward, PE, White, HD, Thompson, TD, Califf, RM, and Topol, EJ. "Prophylactic lidocaine use in acute myocardial infarction: Incidence and outcomes from two international trials." American Heart Journal 137, no. 5 (January 1, 1999): 799-805. Full Text
  - "Combining thrombolysis with the platelet glycoprotein IIb/IIIa inhibitor lamifiban: results of the Platelet Aggregation Receptor Antagonist Dose Investigation and Reperfusion Gain in Myocardial Infarction (PARADIGM) trial." Journal of the American College of Cardiology 32, no. 7 (December 1998): 2003-2010.
  - Alexander, JH, and Harrington, RA. "Recent antiplatelet drug trials in the acute coronary syndromes. Clinical interpretation of PRISM, PRISM-PLUS, PARAGON A and PURSUIT." Drugs 56, no. 6 (December 1998): 965-976. (Review) Full Text
  - Alexander, JH, Greenbaum, AB, Hudson, MP, Kong, DF, Miller, JM, Tung, CY, and Whellan, DJ. "Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998." Am Heart J 136, no. 1 (July 1998): 176-179. Link to Item
  - Alexander, JH, Greenbaum, AB, Hudson, MP, Kong, DF, Miller, JM, Tung, CY, and Whellan, DJ. "Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998." Am Heart J 135, no. 6 Pt 1 (June 1998): 1099-1114. Link to Item
  - Alexander, JH, Alexander, K, Kong, DF, Tung, CY, and Whellan, D. "Session highlights from the American Heart Association Scientific Sessions: November 9-12, 1997." Am Heart J 135, no. 1 (January 1998): 157-180. Link to Item
  - Alexander, JH, and Harrington, RA. "Antiplatelet and antithrombin therapies in the acute coronary syndromes." Current Opinion in Cardiology 12, no. 4 (July 1997): 427-437. (Review)
  - Alexander, JH, and Harrington, RA. "Adjunctive Antiplatelet Therapy in Acute Myocardial Infarction: The Road to Improved Infarct-Related Artery Patency." J Thromb Thrombolysis 4, no. 3/4 (1997): 353-355. Link to Item
  - Alexander, JH, and Harrington, RA. "Adjunctive antiplatelet therapy in acute myocardial infarction: The road to improved infarct-related artery patency." Journal of Thrombosis and Thrombolysis 4, no. 3-4 (1997): 353-355. Full Text
- Other Articles
  - Castleberry, AW, Williams, JB, Daneshmand, MA, Honeycutt, E, Shaw, LK, Samad, Z, Lopes, RD, Alexander, JH, Mathew, JP, Velazquez, EJ, Milano, CA, and Smith, PK. "Response to letter regarding article, "surgical revascularization is associated with maximal survival in patients with ischemic mitral regurgitation: a 20-year experience"." Circulation 131, no. 11 (March 2015): e378-e379. (Letter) Full Text
- Conference Papers
  - Melloni, C, Dunning, A, Granger, CB, Thomas, L, Khouri, MG, Garcia, DA, Hylek, EM, Hanna, M, Wallentin, L, Gersh, BJ, Douglas, PS, Alexander, JH, and Lopes, RD. "Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial." December 2017. Full Text
  - Avezum, A, Lopes, RD, Schulte, PJ, Lanas, F, Gersh, BJ, Hanna, M, Pais, P, Erol, C, Diaz, R, Bahit, MC, Bartunek, J, De Caterina, R, Goto, S, Ruzyllo, W, Zhu, J, Granger, CB, and Alexander, JH. "Apixaban in Comparison With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: Findings From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial." August 2015. Full Text
  - Hijazi, Z, Wallentin, L, Siegbahn, A, Andersson, U, Alexander, JH, Atar, D, Gersh, BJ, Hanna, M, Harjola, VP, Horowitz, JD, Husted, S, Hylek, EM, Lopes, RD, McMurray, JJV, Granger, CB, and ARISTOTLE Investigators, . "High-sensitivity troponin T and risk stratification in patients with atrial fibrillation during treatment with apixaban or warfarin." January 2014. Full Text

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