John Hunter Peel Alexander

John Hunter Peel Alexander
Professor of Medicine

John H. Alexander, MD, MHS is a cardiologist and Professor of Medicine in the Department of Medicine, Division of Cardiology at Duke University School of Medicine, as well as the Vice Chief, Clinical Research in the Division of Cardiology. He is the Director of Cardiovascular Research at the Duke Clinical Research Institute where he oversees a large group of clinical research faculty and a broad portfolio of cardiovascular clinical trials and observational clinical research programs. He is a member of the American Society of Clinical Investigation.

Dr. Alexander’s clinical interests are in acute and general cardiovascular disease, valvular heart disease, and echocardiology. His research is focused on the translation of novel therapeutic concepts into clinical data through clinical trials, specifically on the therapeutics of acute coronary syndromes, chronic coronary artery disease, and cardiac surgery and on novel methodological approaches to clinical trials. He was on the Executive Committee of the ARISTOTLE trial of apixaban in patients with atrial fibrillation and was the Principal Investigator of the APPRAISE-2 trial of apixaban in patients with acute coronary syndromes.

Dr. Alexander has published extensively and has served as the principal investigator of numerous multicenter clinical trials. He currently serves as the co-chair of the Clinical Trial Transformation Initiative (CTTI).

Current Appointments & Affiliations

Professor of Medicine, Medicine, Cardiology, Medicine 2014
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 1996

Contact Information

200 Morris Street, Durham, NC 27701
Duke Box 17969, Durham, NC 27715
john.h.alexander@duke.edu (919) 668-8955
DCRI Profile
Department of Medicine (Cardiology) Profile

Background
Education, Training, & Certifications
- Fellow in Cardiology, Medicine, Duke University 1996 - 2000
- Medical Resident, Medicine, Children's Hospital, Boston 1993 - 1996
- M.D., University of Pennsylvania 1993
Previous Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2010 - 2014
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2006 - 2010
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2000 - 2006
Recognition
In the News
- MAR 10, 2023 Duke Health News
  
  Can’t Take Statins? There’s Another Choice for Lowering Cholesterol
- MAR 20, 2017 Duke Health News
  
  Drug Could Reduce Serious Complication in Cardiac Bypass Patients
Expertise
Subject Headings
Global Scholarship
- Expertise
  - United States of America (Country)
- Research
  - United States of America (Country)
Research
Selected Grants
- Stimulating Access to Research in Residency (StARR) - NHLBI awarded by National Institutes of Health 2018 - 2028
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program awarded by University of North Carolina - Chapel Hill 2016 - 2026
- OCEANIC Site Budget 2023 - 2025
- Increasing the Quality and Efficiency of Clinical Trials (U18) awarded by Food and Drug Administration 2014 - 2024
- Postdoctoral Training in Cardiovascular Clinical Research awarded by National Institutes of Health 2003 - 2024
- CSL112_STEMI 2017 - 2023
- Myocardial Ischemia and Transfusion (MINT) Steering Committee 2016 - 2023
- ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment with Alirocumab 2018 - 2022
- ClotChip 2020 - 2022
- Core Clinical Centers for the CTSN awarded by National Institutes of Health 2007 - 2018
- Genetics Myocardial Adverse Outcomes/Graft Failure-CABG (Gene-Magic) awarded by National Institutes of Health 2004 - 2011
External Relationships
- AbbVie Pharmaceuticals
- Antev
- Artivion
- Atricure
- Bayer
- Pfizer Inc.
- Portola Pharmaceuticals, Inc.
- Veralox therapeutics
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Hijazi, Ziad, Johan Lindbäck, Jonas Oldgren, Alexander P. Benz, John H. Alexander, Stuart J. Connolly, John W. Eikelboom, et al. “Individual net clinical outcome with oral anticoagulation in atrial fibrillation using the ABC-AF risk scores.” Am Heart J 261 (July 2023): 55–63. https://doi.org/10.1016/j.ahj.2023.03.012.
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  - Rong, Lisa Q., Antonino Di Franco, Mohamed Rahouma, Arnaldo Dimagli, June Chan, Alexandra J. Lopes, Jiwon Kim, et al. “Postoperative pericardial effusion, pericardiotomy, and atrial fibrillation: An explanatory analysis of the PALACS trial.” Am Heart J 260 (June 2023): 113–23. https://doi.org/10.1016/j.ahj.2023.03.001.
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  - Alexander, John H. “Benefits of Bempedoic Acid - Clearer Now.” N Engl J Med 388, no. 15 (April 13, 2023): 1425–26. https://doi.org/10.1056/NEJMe2301490.
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  - Chatterjee, Subhasis, Niv Ad, Vinay Badhwar, A Marc Gillinov, John H. Alexander, and Marc R. Moon. “Anticoagulation for atrial fibrillation after cardiac surgery: Do guidelines reflect the evidence?” J Thorac Cardiovasc Surg, April 8, 2023. https://doi.org/10.1016/j.jtcvs.2023.03.026.
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  - Chu, Michael W. A., Marc Ruel, Allen Graeve, Marc W. Gerdisch, Ralph J. Damiano, Robert L. Smith, William Brent Keeling, et al. “Low-Dose vs Standard Warfarin After Mechanical Mitral Valve Replacement: A Randomized Trial.” Ann Thorac Surg 115, no. 4 (April 2023): 929–38. https://doi.org/10.1016/j.athoracsur.2022.12.031.
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  - Milling, Truman J., Saskia Middeldorp, Lizhen Xu, Bruce Koch, Andrew Demchuk, John W. Eikelboom, Peter Verhamme, et al. “Final Study Report of Andexanet Alfa for Major Bleeding With Factor Xa Inhibitors.” Circulation 147, no. 13 (March 28, 2023): 1026–38. https://doi.org/10.1161/CIRCULATIONAHA.121.057844.
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  - Carson, Jeffrey L., Maria Mori Brooks, Bernard R. Chaitman, John H. Alexander, Shaun G. Goodman, Marnie Bertolet, J Dawn Abbott, et al. “Rationale and design for the myocardial ischemia and transfusion (MINT) randomized clinical trial.” Am Heart J 257 (March 2023): 120–29. https://doi.org/10.1016/j.ahj.2022.11.015.
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  - Montalescot, Gilles, John H. Alexander, Angel Cequier-Fillat, Scott D. Solomon, Alban Redheuil, Martin Hudec, Johanne Silvain, et al. “Firibastat Versus Ramipril After Acute Mechanical Reperfusion of Anterior Myocardial Infarction: A Phase 2 Study.” Am J Cardiovasc Drugs 23, no. 2 (March 2023): 207–17. https://doi.org/10.1007/s40256-023-00567-8.
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  - Harrington, Josephine, Jonathan P. Piccini, John H. Alexander, Christopher B. Granger, and Manesh R. Patel. “Clinical Evaluation of Factor XIa Inhibitor Drugs: JACC Review Topic of the Week.” J Am Coll Cardiol 81, no. 8 (February 28, 2023): 771–79. https://doi.org/10.1016/j.jacc.2022.11.057.
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  - Gaudino, Mario, John Alexander, Umberto Benedetto, Andreas Boening, Arnaldo Dimagli, Stephen Fremes, Joanna Chikwe, et al. “Omnia munda mundis ('to the pure, all things are pure').” Eur J Cardiothorac Surg 63, no. 2 (February 3, 2023). https://doi.org/10.1093/ejcts/ezad021.
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  - Hijazi, Ziad, Alexander P. Benz, Johan Lindbäck, John H. Alexander, Stuart J. Connolly, John W. Eikelboom, Christopher B. Granger, et al. “Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation.” Eur Heart J 44, no. 3 (January 14, 2023): 208–18. https://doi.org/10.1093/eurheartj/ehac632.
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  - Goldstein, Daniel J., Helena L. Chang, Michael J. Mack, Pierre Voisine, James S. Gammie, Mary E. Marks, Alexander Iribarne, et al. “Intimal hyperplasia, saphenous vein graft disease, and clinical outcomes: Insights from the CTSN VEST randomized trial.” J Thorac Cardiovasc Surg, October 30, 2022. https://doi.org/10.1016/j.jtcvs.2022.10.034.
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  - Rao, Sunil V., Bodo Kirsch, Deepak L. Bhatt, Andrzej Budaj, Rosa Coppolecchia, John Eikelboom, Stefan K. James, et al. “A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction.” Circulation 146, no. 16 (October 18, 2022): 1196–1206. https://doi.org/10.1161/CIRCULATIONAHA.122.061612.
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  - Al-Khatib, Sana M., Daniel M. Wojdyla, Christopher B. Granger, Lars Wallentin, David A. Garcia, Ziad Hijazi, Claes Held, et al. “Duration of Anticoagulation Interruption Before Invasive Procedures and Outcomes in Patients With Atrial Fibrillation: Insights From the ARISTOTLE Trial.” Circulation 146, no. 12 (September 20, 2022): 958–60. https://doi.org/10.1161/CIRCULATIONAHA.122.059438.
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  - Attar, Rubina, Angie Wu, Daniel Wojdyla, Svend Eggert Jensen, Pontus Andell, Kenneth W. Mahaffey, Matthew T. Roe, et al. “Outcomes After Acute Coronary Syndrome in Patients With Diabetes Mellitus and Peripheral Artery Disease (from the TRACER, TRILOGY-ACS, APPRAISE-2, and PLATO Clinical Trials).” Am J Cardiol 178 (September 1, 2022): 11–17. https://doi.org/10.1016/j.amjcard.2022.04.062.
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  - Aulin, Julia, Ziad Hijazi, Johan Lindbäck, John H. Alexander, Bernard J. Gersh, Christopher B. Granger, Michael Hanna, et al. “Biomarkers and heart failure events in patients with atrial fibrillation in the ARISTOTLE trial evaluated by a multi-state model.” Am Heart J 251 (September 2022): 13–24. https://doi.org/10.1016/j.ahj.2022.03.009.
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  - Caruba, Thibaut, Anaïs Charles-Nelson, John H. Alexander, Rajendra H. Mehta, Matthias Heringlake, Wolfgang Toller, Amelie Yavchitz, Brigitte Sabatier, Gilles Chatellier, and Bernard Cholley. “Prophylactic levosimendan in patients with low ejection fraction undergoing coronary artery bypass grafting: A pooled analysis of two multicentre randomised controlled trials.” Anaesth Crit Care Pain Med 41, no. 4 (August 2022): 101107. https://doi.org/10.1016/j.accpm.2022.101107.
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  - Goldstein, Daniel J., John D. Puskas, John H. Alexander, Helena L. Chang, James S. Gammie, Mary E. Marks, Alexander Iribarne, et al. “External Support for Saphenous Vein Grafts in Coronary Artery Bypass Surgery: A Randomized Clinical Trial.” Jama Cardiol 7, no. 8 (August 1, 2022): 808–16. https://doi.org/10.1001/jamacardio.2022.1437.
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  - Pol, Tymon, Ziad Hijazi, Johan Lindbäck, Jonas Oldgren, John H. Alexander, Stuart J. Connolly, John W. Eikelboom, et al. “Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation.” Cardiovasc Res 118, no. 9 (July 20, 2022): 2112–23. https://doi.org/10.1093/cvr/cvab262.
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  - Bahit, M Cecilia, Amit N. Vora, Zhuokai Li, Daniel M. Wojdyla, Laine Thomas, Shaun G. Goodman, Ronald Aronson, et al. “Apixaban or Warfarin and Aspirin or Placebo After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Patients With Atrial Fibrillation and Prior Stroke: A Post Hoc Analysis From the AUGUSTUS Trial.” Jama Cardiol 7, no. 7 (July 1, 2022): 682–89. https://doi.org/10.1001/jamacardio.2022.1166.
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  - Macedo, Ariane Vieira Scarlatelli, Pedro Gabriel Melo de Barros E Silva, Thiago Ceccatto de Paula, Renata Junqueira Moll-Bernardes, Tiago Mendonça Dos Santos, Lilian Mazza, Andre Feldman, et al. “Discontinuing vs continuing ACEIs and ARBs in hospitalized patients with COVID-19 according to disease severity: Insights from the BRACE CORONA trial.” Am Heart J 249 (July 2022): 86–97. https://doi.org/10.1016/j.ahj.2022.04.001.
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  - Gaudino, Mario, Katia Audisio, Antonino Di Franco, John H. Alexander, Paul Kurlansky, Andreas Boening, Joanna Chikwe, et al. “Radial artery versus saphenous vein versus right internal thoracic artery for coronary artery bypass grafting.” Eur J Cardiothorac Surg 62, no. 1 (June 15, 2022). https://doi.org/10.1093/ejcts/ezac345.
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  - Verma, Sanam, Sarah Rathwell, Stephen Fremes, Yinggan Zheng, Rajendra Mehta, Renato D. Lopes, John H. Alexander, Shaun G. Goodman, Sean van Diepen, and Sean van LEVO-CTS investigators. “Associated factors and clinical outcomes in mechanical circulatory support use in patients undergoing high risk on-pump cardiac surgery: Insights from the LEVO-CTS trial.” Am Heart J 248 (June 2022): 35–41. https://doi.org/10.1016/j.ahj.2022.02.013.
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  - De Caterina, Raffaele, Giuseppe Patti, Johan Westerbergh, John Horowitz, Justin A. Ezekowitz, Basil S. Lewis, Renato D. Lopes, et al. “Heterogeneity of diabetes as a risk factor for major adverse cardiovascular events in anticoagulated patients with atrial fibrillation: an analysis of the ARISTOTLE trial.” Eur Heart J Cardiovasc Pharmacother 8, no. 3 (May 5, 2022): 227–35. https://doi.org/10.1093/ehjcvp/pvaa140.
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  - Bagiella, Emilia, John D. Puskas, Alan J. Moskowitz, Annetine C. Gelijns, John H. Alexander, Jagat Narula, Peter K. Smith, et al. “Rationale and design of a randomized trial evaluating an external support device for saphenous vein coronary grafts.” Am Heart J 246 (April 2022): 12–20. https://doi.org/10.1016/j.ahj.2021.12.009.
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  - Alexander, John H. “Equipoise in Clinical Trials: Enough Uncertainty in Whose Opinion?” Circulation 145, no. 13 (March 29, 2022): 943–45. https://doi.org/10.1161/CIRCULATIONAHA.121.057201.
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  - Harskamp, Ralf E., Alexander C. Fanaroff, Renato D. Lopes, Daniel M. Wojdyla, Shaun G. Goodman, Laine E. Thomas, Ronald Aronson, et al. “Antithrombotic Therapy in Patients With Atrial Fibrillation After Acute Coronary Syndromes or Percutaneous Intervention.” J Am Coll Cardiol 79, no. 5 (February 8, 2022): 417–27. https://doi.org/10.1016/j.jacc.2021.11.035.
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  - Welsh, Robert C., Payam Dehghani, Renato Lopes, Daniel M. Wojdyla, Ronald Aronson, Christopher B. Granger, Stephan Windecker, et al. “Impact of prior oral anticoagulant use and outcomes on patients from secondary analysis in the AUGUSTUS trial.” Open Heart 9, no. 1 (February 2022). https://doi.org/10.1136/openhrt-2021-001892.
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  - Carnicelli, Anthony P., Hwanhee Hong, Stuart J. Connolly, John Eikelboom, Robert P. Giugliano, David A. Morrow, Manesh R. Patel, et al. “Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex.” Circulation 145, no. 4 (January 25, 2022): 242–55. https://doi.org/10.1161/CIRCULATIONAHA.121.056355.
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  - Attelind, Sofia, Pär Hallberg, Mia Wadelius, Anna-Karin Hamberg, Agneta Siegbahn, Christopher B. Granger, Renato D. Lopes, John H. Alexander, Lars Wallentin, and Niclas Eriksson. “Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events.” Front Genet 13 (2022): 982955. https://doi.org/10.3389/fgene.2022.982955.
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  - Gaudino, Mario, Antonino Di Franco, John H. Alexander, Faisal Bakaeen, Natalia Egorova, Paul Kurlansky, Andreas Boening, et al. “Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data.” Eur Heart J 43, no. 1 (December 28, 2021): 18–28. https://doi.org/10.1093/eurheartj/ehab504.
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  - Fudim, Marat, Daniel M. Wojdyla, John H. Alexander, Shaun G. Goodman, Roxana Mehran, Stephan Windecker, Ronald Aronson, et al. “Efficacy and Safety of Antithrombotic Therapy in Patients With Atrial Fibrillation, Recent Acute Coronary Syndrome, or Percutaneous Coronary Intervention and a History of Heart Failure: Insights From the AUGUSTUS Trial.” J Am Heart Assoc 10, no. 24 (December 21, 2021): e023143. https://doi.org/10.1161/JAHA.121.023143.
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  - Gelijns, Annetine C., Alan J. Moskowitz, Patrick T. O’Gara, Gennaro Giustino, Michael J. Mack, Donna M. Mancini, Emilia Bagiella, et al. “Transcatheter mitral valve repair for functional mitral regurgitation: Evaluating the evidence.” J Thorac Cardiovasc Surg 162, no. 5 (November 2021): 1504–11. https://doi.org/10.1016/j.jtcvs.2020.02.132.
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  - Siegbahn, Agneta, Johan Lindbäck, Ziad Hijazi, Mikael Åberg, John H. Alexander, John W. Eikelboom, Renato D. Lopes, et al. “Multiplex protein screening of biomarkers associated with major bleeding in patients with atrial fibrillation treated with oral anticoagulation.” J Thromb Haemost 19, no. 11 (November 2021): 2726–37. https://doi.org/10.1111/jth.15498.
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  - Lopes, Renato D., Celestia S. Higano, Susan F. Slovin, Adam J. Nelson, Robert Bigelow, Per S. Sørensen, Chiara Melloni, et al. “Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial.” Circulation 144, no. 16 (October 19, 2021): 1295–1307. https://doi.org/10.1161/CIRCULATIONAHA.121.056810.
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  - Lopes, Renato D., Pedro Gabriel Melo de Barros E Silva, Remo H. M. Furtado, John H. Alexander, and Otavio Berwanger. “Age-adjusted D-dimer cutoffs to guide anticoagulation in COVID-19 - Authors' reply.” Lancet 398, no. 10308 (October 9, 2021): 1304. https://doi.org/10.1016/S0140-6736(21)01909-7.
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  - Wanner, C., M. E. Cooper, O. E. Johansen, R. Toto, J. Rosenstock, D. K. McGuire, S. E. Kahn, et al. “Erratum to: Effect of linagliptin versus placebo on cardiovascular and kidney outcomes in nephroticrange proteinuria and type 2 diabetes (t2d): the carmelina randomised controlled trial (Clinical Kidney Journal (sfaa225) DOI: 10.1093/ckj/sfaa225).” Clinical Kidney Journal 14, no. 9 (September 1, 2021): 2136. https://doi.org/10.1093/ckj/sfab104.
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  - Schwartz, Gregory G., Michael Szarek, Vera A. Bittner, Rafael Diaz, Shaun G. Goodman, J Wouter Jukema, Ulf Landmesser, et al. “Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol.” J Am Coll Cardiol 78, no. 5 (August 3, 2021): 421–33. https://doi.org/10.1016/j.jacc.2021.04.102.
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  - Lopes, Renato D., Pedro Gabriel Melo de Barros E Silva, Remo H. M. Furtado, Ariane Vieira Scarlatelli Macedo, Eduardo Ramacciotti, Lucas Petri Damini, Bruna Bronhara, et al. “Randomized clinical trial to evaluate a routine full anticoagulation Strategy in Patients with Coronavirus Infection (SARS-CoV2) admitted to hospital: Rationale and design of the ACTION (AntiCoagulaTlon cOroNavirus)-Coalition IV trial.” Am Heart J 238 (August 2021): 1–11. https://doi.org/10.1016/j.ahj.2021.04.005.
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  - Goyal, Akash, Tony Schibler, Brooke Alhanti, Karen L. Hannan, Christopher B. Granger, Michael A. Blazing, Renato D. Lopes, et al. “Assessment of North American Clinical Research Site Performance During the Start-up of Large Cardiovascular Clinical Trials.” Jama Netw Open 4, no. 7 (July 1, 2021): e2117963. https://doi.org/10.1001/jamanetworkopen.2021.17963.
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  - Lopes, Renato D., Pedro Gabriel Melo de Barros E Silva, Remo H. M. Furtado, Ariane Vieira Scarlatelli Macedo, Bruna Bronhara, Lucas Petri Damiani, Lilian Mazza Barbosa, et al. “Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial.” Lancet 397, no. 10291 (June 12, 2021): 2253–63. https://doi.org/10.1016/S0140-6736(21)01203-4.
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  - Carnicelli, Anthony P., Sana M. Al-Khatib, Denis Xavier, Frederik Dalgaard, Peter D. Merrill, Daniel M. Wojdyla, Basil S. Lewis, et al. “Premature permanent discontinuation of apixaban or warfarin in patients with atrial fibrillation.” Heart 107, no. 9 (May 2021): 713–20. https://doi.org/10.1136/heartjnl-2020-317229.
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  - Gaudino, Mario, Antonino Di Franco, Deepak L. Bhatt, John H. Alexander, Antonio Abbate, Lorenzo Azzalini, Sigrid Sandner, et al. “The association between coronary graft patency and clinical status in patients with coronary artery disease.” Eur Heart J 42, no. 14 (April 7, 2021): 1433–41. https://doi.org/10.1093/eurheartj/ehab096.
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  - Hijazi, Ziad, John H. Alexander, Zhuokai Li, Daniel M. Wojdyla, Roxana Mehran, Christopher B. Granger, Alexander Parkhomenko, et al. “Apixaban or Vitamin K Antagonists and Aspirin or Placebo According to Kidney Function in Patients With Atrial Fibrillation After Acute Coronary Syndrome or Percutaneous Coronary Intervention: Insights From the AUGUSTUS Trial.” Circulation 143, no. 12 (March 23, 2021): 1215–23. https://doi.org/10.1161/CIRCULATIONAHA.120.051020.
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  - Carnicelli, Anthony P., Hwanhee Hong, Robert P. Giugliano, Stuart J. Connolly, John Eikelboom, Manesh R. Patel, Lars Wallentin, et al. “Individual Patient Data from the Pivotal Randomized Controlled Trials of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation (COMBINE AF): Design and Rationale: From the COMBINE AF (A Collaboration between Multiple institutions to Better Investigate Non-vitamin K antagonist oral anticoagulant use in Atrial Fibrillation) Investigators.” Am Heart J 233 (March 2021): 48–58. https://doi.org/10.1016/j.ahj.2020.12.002.
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  - Al-Khatib, Sana M., Hillary Mulder, Daniel Wojdyla, Renato D. Lopes, Lars Wallentin, John H. Alexander, Ziad Hijazi, Shinya Goto, and Christopher B. Granger. “Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Left Ventricular Hypertrophy: Insights From the ARISTOTLE Trial.” Circ Arrhythm Electrophysiol 14, no. 3 (March 2021): e009614. https://doi.org/10.1161/CIRCEP.120.009614.
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  - Al-Khatib, Sana M., Hillary Mulder, Daniel Wojdyla, Renato D. Lopes, Lars Wallentin, John H. Alexander, Ziad Hijazi, Shinya Goto, and Christopher B. Granger. “Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Left Ventricular Hypertrophy.” Circulation: Arrhythmia and Electrophysiology 14, no. 3 (March 2021). https://doi.org/10.1161/circep.120.009614.
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  - Pol, Tymon, Ziad Hijazi, Johan Lindbäck, John H. Alexander, M Cecilia Bahit, Raffaele De Caterina, J. W. Eikelboom, et al. “Evaluation of the prognostic value of GDF-15, ABC-AF-bleeding score and ABC-AF-death score in patients with atrial fibrillation across different geographical areas.” Open Heart 8, no. 1 (March 2021). https://doi.org/10.1136/openhrt-2020-001471.
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  - Bertrand, Philippe B., Jessica R. Overbey, Xin Zeng, Robert A. Levine, Gorav Ailawadi, Michael A. Acker, Peter K. Smith, et al. “Progression of Tricuspid Regurgitation After Surgery for Ischemic Mitral Regurgitation.” J Am Coll Cardiol 77, no. 6 (February 16, 2021): 713–24. https://doi.org/10.1016/j.jacc.2020.11.066.
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  - Lopes, Renato D., Amit N. Vora, and John H. Alexander. “Antithrombotic Strategies in Patients With Atrial Fibrillation and Percutaneous Coronary Intervention-Reply.” Jama Cardiol 6, no. 2 (February 1, 2021): 241. https://doi.org/10.1001/jamacardio.2020.4759.
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  - Lopes, Renato D., Ariane V. S. Macedo, Pedro G. M. de Barros E Silva, Renata J. Moll-Bernardes, Tiago M. Dos Santos, Lilian Mazza, André Feldman, et al. “Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial.” Jama 325, no. 3 (January 19, 2021): 254–64. https://doi.org/10.1001/jama.2020.25864.
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  - Alexander, John H. “Preventing Atrial Fibrillation After Cardiac Surgery: What Matters Most.” J Am Coll Cardiol 77, no. 1 (January 5, 2021): 68–70. https://doi.org/10.1016/j.jacc.2020.10.050.
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  - Gibson, C Michael, John J. P. Kastelein, Adam T. Phillips, Philip E. Aylward, Megan K. Yee, Michal Tendera, Stephen J. Nicholls, et al. “Rationale and design of ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II): A phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of CSL112 in subjects after acute myocardial infarction.” Am Heart J 231 (January 2021): 121–27. https://doi.org/10.1016/j.ahj.2020.10.052.
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  - Jawitz, Oliver K., Amanda S. Stebbins, Vignesh Raman, Brooke Alhanti, Sean van Diepen, Matthias Heringlake, Stephen Fremes, et al. “Association between levosimendan, postoperative AKI, and mortality in cardiac surgery: Insights from the LEVO-CTS trial.” Am Heart J 231 (January 2021): 18–24. https://doi.org/10.1016/j.ahj.2020.10.066.
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  - Wanner, Christoph, Mark E. Cooper, Odd Erik Johansen, Robert Toto, Julio Rosenstock, Darren K. McGuire, Steven E. Kahn, et al. “Effect of linagliptin versus placebo on cardiovascular and kidney outcomes in nephrotic-range proteinuria and type 2 diabetes: the CARMELINA randomized controlled trial.” Clin Kidney J 14, no. 1 (January 2021): 226–36. https://doi.org/10.1093/ckj/sfaa225.
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  - Hijazi, Ziad, Lars Wallentin, Johan Lindbäck, John H. Alexander, Stuart J. Connolly, John W. Eikelboom, Michael D. Ezekowitz, et al. “Screening of Multiple Biomarkers Associated With Ischemic Stroke in Atrial Fibrillation.” J Am Heart Assoc 9, no. 24 (December 15, 2020): e018984. https://doi.org/10.1161/JAHA.120.018984.
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  - Alexander, J. H., R. A. Sparapani, K. W. Mahaffey, J. W. Deckers, L. K. Newby, E. M. Ohman, R. Corbalán, et al. “Association between minor elevations of creatine kinase-MB level and mortality in patients with acute coronary syndromes without ST-segment elevation. PURSUIT Steering Committee. Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy.” Jama 283, no. 3 (January 19, 2000): 347–53. https://doi.org/10.1001/jama.283.3.347.
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  - McGuire, D. K., M. P. Hudson, M. A. East, C. K. Dyke, W. J. Cantor, J. Battle, M. C. Bahit, S. M. Al-Khatib, and J. H. Alexander. “Highlights from the American Heart Association 72nd Scientific Sessions: November 6 to 10, 1999.” American Heart Journal 139, no. 2 (January 1, 2000): 359–70. https://doi.org/10.1016/S0002-8703(00)90247-3.
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  - Patel, M., S. S. Han, K. Vaux, J. Saalfeld, and J. H. Alexander. “A protocol of early spiral computed tomography for the detection of stones in patients with renal colic has reduced the time to diagnosis and overall management costs.” Aust N Z J Surg 70, no. 1 (January 2000): 39–42. https://doi.org/10.1046/j.1440-1622.2000.01740.x.
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  - Alexander, J. H., S. Al-Khatib, W. Cantor, A. B. Greenbaum, M. P. Hudson, D. F. Kong, and M. Shah. “Highlights from the American College of Cardiology 48th Annual Scientific Sessions: March 7 to 10, 1999.” Am Heart J 138, no. 1 Pt 1 (July 1999): 175–90. https://doi.org/10.1016/s0002-8703(99)90000-5.
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  - Pertusi, R. M., K. S. Godwin, J. K. House, J. A. Knebl, J. H. Alexander, B. R. Rubin, and M. D. Forman. “Gastropathy induced by nonsteroidal anti-inflammatory drugs: prescribing patterns among geriatric practitioners.” J Am Osteopath Assoc 99, no. 6 (June 1999): 305–10. https://doi.org/10.7556/jaoa.1999.99.6.305.
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  - Sadowski, Z. P., J. H. Alexander, B. Skrabucha, A. Dyduszynski, J. Kuch, E. Nartowicz, G. Swiatecka, D. F. Kong, and C. B. Granger. “Multicenter randomized trial and a systematic overview of lidocaine in acute myocardial infarction.” Am Heart J 137, no. 5 (May 1999): 792–98. https://doi.org/10.1016/s0002-8703(99)70401-1.
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  - Alexander, J. H., C. B. Granger, Z. Sadowski, P. E. Aylward, H. D. White, T. D. Thompson, R. M. Califf, and E. J. Topol. “Prophylactic lidocaine use in acute myocardial infarction: incidence and outcomes from two international trials. The GUSTO-I and GUSTO-IIb Investigators.” Am Heart J 137, no. 5 (May 1999): 799–805. https://doi.org/10.1016/s0002-8703(99)70402-3.
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  - Eachempati, S. R., C. Young, J. Alexander, F. D. Cirisano, G. C. Rodriguez, and R. L. Reed. “The clinical use of an esophageal Doppler monitor for hemodynamic monitoring in sepsis.” J Clin Monit Comput 15, no. 3–4 (May 1999): 223–25. https://doi.org/10.1023/a:1009963124127.
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  - Alexander, J. H., R. A. Harrington, R. H. Tuttle, L. G. Berdan, A. M. Lincoff, J. W. Deckers, M. L. Simoons, et al. “Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes. PURSUIT Investigators. Platelet IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy.” Am J Cardiol 83, no. 8 (April 15, 1999): 1147–51. https://doi.org/10.1016/s0002-9149(99)00049-1.
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  - Alexander, J. H., D. F. Kong, and W. J. Cantor. “Highlights from the 71st American Heart Association Scientific Sessions: November 8 to 11, 1998.” Am Heart J 137, no. 3 (March 1999): 555–74. https://doi.org/10.1016/s0002-8703(99)70506-5.
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  - Alexander, J. H., and R. A. Harrington. “Recent antiplatelet drug trials in the acute coronary syndromes. Clinical interpretation of PRISM, PRISM-PLUS, PARAGON A and PURSUIT.” Drugs 56, no. 6 (December 1998): 965–76. https://doi.org/10.2165/00003495-199856060-00002.
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  - “Combining thrombolysis with the platelet glycoprotein IIb/IIIa inhibitor lamifiban: results of the Platelet Aggregation Receptor Antagonist Dose Investigation and Reperfusion Gain in Myocardial Infarction (PARADIGM) trial.” J Am Coll Cardiol 32, no. 7 (December 1998): 2003–10. https://doi.org/10.1016/s0735-1097(98)00474-4.
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  - Alexander, J. H., A. B. Greenbaum, M. P. Hudson, D. F. Kong, J. M. Miller, C. Y. Tung, and D. J. Whellan. “Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998.” Am Heart J 136, no. 1 (July 1998): 176–79. https://doi.org/10.1016/s0002-8703(98)70199-1.
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  - Alexander, J. H., A. B. Greenbaum, M. P. Hudson, D. F. Kong, J. M. Miller, C. Y. Tung, and D. J. Whellan. “Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998.” Am Heart J 135, no. 6 Pt 1 (June 1998): 1099–1114. https://doi.org/10.1016/s0002-8703(98)70079-1.
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  - Alexander, J. H., K. Alexander, D. F. Kong, C. Y. Tung, and D. Whellan. “Session highlights from the American Heart Association Scientific Sessions: November 9-12, 1997.” Am Heart J 135, no. 1 (January 1998): 157–80. https://doi.org/10.1016/s0002-8703(98)70357-6.
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  - Alexander, J. H., and R. A. Harrington. “Antiplatelet and antithrombin therapies in the acute coronary syndromes.” Curr Opin Cardiol 12, no. 4 (July 1997): 427–37.
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  - Alexander, J. H., and R. A. Harrington. “Adjunctive Antiplatelet Therapy in Acute Myocardial Infarction: The Road to Improved Infarct-Related Artery Patency.” J Thromb Thrombolysis 4, no. 3/4 (1997): 353–55. https://doi.org/10.1023/a:1008845315933.
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- Other Articles
  - Castleberry, Anthony W., Judson B. Williams, Mani A. Daneshmand, Emily Honeycutt, Linda K. Shaw, Zainab Samad, Renato D. Lopes, et al. “Response to letter regarding article, "surgical revascularization is associated with maximal survival in patients with ischemic mitral regurgitation: a 20-year experience".” Circulation, March 17, 2015. https://doi.org/10.1161/CIRCULATIONAHA.114.013125.
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- Conference Papers
  - Marquis-Gravel, Guillaume, Laurie-Anne Boivin-Proulx, Zhen Huang, Steven L. Zelenkofske, A Michael Lincoff, Roxana Mehran, P Gabriel Steg, Christoph Bode, John H. Alexander, and Thomas J. Povsic. “Femoral Vascular Closure Devices and Bleeding, Hemostasis, and Ambulation Following Percutaneous Coronary Intervention.” In J Am Heart Assoc, 12:e025666, 2023. https://doi.org/10.1161/JAHA.122.025666.
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  - Melloni, Chiara, Allison Dunning, Christopher B. Granger, Laine Thomas, Michel G. Khouri, David A. Garcia, Elaine M. Hylek, et al. “Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial.” In Am J Med, 130:1440-1448.e1, 2017. https://doi.org/10.1016/j.amjmed.2017.06.026.
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  - Avezum, Alvaro, Renato D. Lopes, Phillip J. Schulte, Fernando Lanas, Bernard J. Gersh, Michael Hanna, Prem Pais, et al. “Apixaban in Comparison With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: Findings From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial.” In Circulation, 132:624–32, 2015. https://doi.org/10.1161/CIRCULATIONAHA.114.014807.
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  - Hijazi, Ziad, Lars Wallentin, Agneta Siegbahn, Ulrika Andersson, John H. Alexander, Dan Atar, Bernard J. Gersh, et al. “High-sensitivity troponin T and risk stratification in patients with atrial fibrillation during treatment with apixaban or warfarin.” In J Am Coll Cardiol, 63:52–61, 2014. https://doi.org/10.1016/j.jacc.2013.07.093.
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- Preprints
  - Jhand, Aravdeep S., Waiel Abusnina, Hyo Jung Tak, Arslan Ahmed, Mahmoud Ismayl, S Elissa Altin, Matthew W. Sherwood, et al. “Impact of Anemia on Outcomes and Resource Utilization in Patients with Myocardial Infarction: A National Database Analysis.” Cold Spring Harbor Laboratory, March 3, 2023. https://doi.org/10.1101/2023.02.28.23286603.
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