John Norman Norton

Journal Article J Am Assoc Lab Anim Sci · March 1, 2024 Vibration is inherent in research animal facilities due to the mechanical systems and practices required for animal care and use. Ample evidence indicates that vibration can change behavior and physiology in multiple species, potentially altering the resul ... Full text Link to item Cite

Sound and Vibration as Research Variables in Terrestrial Vertebrate Models.

Journal Article ILAR J · October 19, 2020 Sound and vibration have been shown to alter animal behavior and induce physiological changes as well as to cause effects at the cellular and molecular level. For these reasons, both environmental factors have a considerable potential to alter research out ... Full text Link to item Cite

Managing Research Animal Specimens and Laboratory Safety.

Journal Article ILAR J · December 31, 2018 The procedures necessary to perform testing in a veterinary diagnostic laboratory have inherent associated risks to personnel in regard to exposure to infectious agents. In research institutions animals can be experimentally infected, acquire naturally occ ... Full text Link to item Cite

Foreword and Introduction to This Issue on Contemporary Safety Topics in Animal Research.

Journal Article ILAR J · December 31, 2018 Institutions with animal care and use programs are obligated to provide for the health and well-being of the animals, but are equally obligated to provide for safety of individuals associated with the program. The topics in this issue of the ILAR Journal, ... Full text Link to item Cite

Vibration-induced Behavioral Responses and Response Threshold in Female C57BL/6 Mice.

Journal Article J Am Assoc Lab Anim Sci · September 1, 2018 Despite documented adverse effects, limits for rodent exposure to vibration in the laboratory animal facility have not been established. This study used female C57BL/6 mice to determine the frequencies of vibration at which mice were most sensitive to beha ... Full text Link to item Cite

Vibration in mice: A review of comparative effects and use in translational research.

Journal Article Animal Model Exp Med · June 2018 Sound pressure waves surround individuals in everyday life and are perceived by animals and humans primarily through sound or vibration. When sound pressure waves traverse through a solid medium, vibration will result. Vibration has long been considered an ... Full text Link to item Cite

Assessing the satisfaction and burden within an academic animal care and use program.

Journal Article FASEB J · September 2017 Although animal research requires adherence to various regulations and standards, the manner in which compliance is maintained and the degree of additional constraints varies between institutions. Regulatory burden, particularly if institutionally imposed, ... Full text Link to item Cite

Environmental Factors: Macroenvironment versus Microenvironment

Chapter · January 1, 2017 Animals used in research, teaching, and testing are complex living creatures that respond to environmental parameters. Whether living in a tightly controlled internal environment or an outdoor environment subject to weather changes, animals, through their ... Full text Cite

Future Directions and Challenges

Chapter · January 1, 2017 The latter part of the twentieth century and beginning of the twenty-first century represents an age of scientific discovery, knowledge application, globalization, and social awareness that are unlike any other periods in the history of the world. The last ... Full text Cite

Management of Animal Care and Use Programs in Research, Education, and Testing: SECOND EDITION

Book · January 1, 2017 AAP Prose Award Finalist 2018/19 Management of Animal Care and Use Programs in Research, Education, and Testing, Second Edition is the extensively expanded revision of the popular Management of Laboratory Animal Care and Use Programs book published earlier ... Full text Cite

Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats.

Journal Article Invest New Drugs · April 2016 D2C7-(scdsFv)-PE38KDEL (D2C7-IT) is a novel immunotoxin that reacts with wild-type epidermal growth factor receptor (EGFRwt) and mutant EGFRvIII proteins overexpressed in glioblastomas. This study assessed the toxicity of intracerebral administration of D2 ... Full text Link to item Cite

Vibrating Frequency Thresholds in Mice and Rats: Implications for the Effects of Vibrations on Animal Health.

Journal Article Ann Biomed Eng · August 2015 Vibrations in research facilities can cause complex animal behavioral and physiological responses that can affect animal health and research outcomes. The goal of this study was to determine the range of frequency values, where animals are unable to attenu ... Full text Link to item Cite

Characteristics of Vibration that Alter Cardiovascular Parameters in Mice.

Journal Article J Am Assoc Lab Anim Sci · July 2015 We hypothesized that short-term exposure of mice to vibration within a frequency range thought to be near the resonant frequency range of mouse tissue and at an acceleration of 0 to 1 m/s(2) would alter heart rate (HR) and mean arterial pressure (MAP). We ... Link to item Cite

The cost of self-imposed regulatory burden in animal research.

Journal Article FASEB J · August 2014 U.S. federal regulations and standards governing the care and use of research animals enacted in the mid- to late 1980s, while having positive effects on the welfare and quality of the animals, have resulted in dramatic increases in overall research costs. ... Full text Link to item Cite

A sample Postapproval monitoring program in academia

Journal Article ILAR Journal · September 11, 2012 The primary goal of an animal care and use program (ACUP) should be to ensure animal well-being while fostering progressive science. Both the Animal Welfare Act (and associated regulations) and the Public Health Service (PHS) Policy require the institution ... Cite

Diseases and Veterinary Care

Journal Article · January 1, 2012 This chapter describes the diseases prevalence in chinchillas, which are usually related to the pet trade. Diseases in chinchillas that are housed within well-managed research facilities are less. The most abnormal health conditions in chinchillas are due ... Full text Cite

Comparative vibration levels perceived among species in a laboratory animal facility.

Journal Article J Am Assoc Lab Anim Sci · September 2011 The current study was performed to determine the vibration levels that were generated in cages on a ventilated rack by common construction equipment in frequency ranges likely to be perceived by humans, rats, and mice. Vibration generated by the ventilated ... Link to item Cite

Vibration Inside of a Mouse Cage Caused by Construction Equipment

Conference JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE · September 1, 2011 Link to item Cite

Noise in a laboratory animal facility from the human and mouse perspectives.

Journal Article J Am Assoc Lab Anim Sci · September 2010 The current study was performed to understand the level of sound produced by ventilated racks, animal transfer stations, and construction equipment that mice in ventilated cages hear relative to what humans would hear in the same environment. Although the ... Link to item Cite

Evaluation of Common Husbandry Equipment Sound Levels Perceived by Mice and Humans

Conference JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE · September 1, 2010 Link to item Cite

A Novel Training Approach for Ensuring Compliance with Personal Protective Equipment Doffing Procedures in ABSL3 Vivaria

Conference JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE · September 1, 2010 Link to item Cite

Evaluation of Noise from Common Construction Implements in the Mouse Environment

Conference JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE · September 1, 2010 Link to item Cite

The planning, design and construction process

Journal Article · December 1, 2009 This chapter describes the design process from conceptual design through all phases of engineering and construction of new facilities. The chapter also describes various design issues and potential pitfalls. The major activities in the design of an animal ... Full text Cite

Biosecurity Lockout System to Influence Human Trafficking: Ingress Control as a Component of the Prevention of Rodent Infectious Agent Transmission

Conference JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE · September 1, 2008 Link to item Cite

A sample postapproval monitoring program in academia.

Journal Article ILAR J · 2008 The primary goal of an animal care and use program (ACUP) should be to ensure animal well-being while fostering progressive science. Both the Animal Welfare Act (and associated regulations) and the Public Health Service (PHS) Policy require the institution ... Full text Link to item Cite

Ocular melanoma in a Long Evans rat.

Journal Article Contemp Top Lab Anim Sci · January 2004 During a long-term study, a rat exposed to half-amplitude band pass fluorescent blue light (434 to 475 nm) and receiving a calcium channel blocker developed an ocular mass. By visual examination, a presumptive diagnosis of ocular melanoma was made. Subsequ ... Link to item Cite

Ocular biocompatibility testing of intraocular lenses: a 1 year study in pseudophakic rabbit eyes.

Journal Article J Cataract Refract Surg · November 1999 PURPOSE: To evaluate the appropriate duration for conducting ocular biocompatibility studies with an intraocular lens (IOL) in the pseudophakic rabbit model. SETTING: Alcon Laboratories, Inc., Fort Worth, Texas, USA. METHODS: A single-piece biconvex poly(m ... Full text Link to item Cite

Characterization of the effects of tebufelone on hepatic cytochromes P450 in the beagle dog.

Journal Article Drug Metab Dispos · May 1996 Tebufelone (1-[3,5-bis(1,1-dimethylethyl)-4-hydroxy-phenyl]-hex-5-yne-1-one) is an investigational ditertiary butylphenol nonsteroidal anti-inflammatory drug. The purpose of the present study was to assess the effects of tebufelone on hepatocyte ultrastruc ... Link to item Cite

In vitro oral mucosa irritation testing with human cell cultures

Journal Article Toxicology in Vitro · January 1, 1995 Cell cultures are a potentially useful model to predict in vivo oral mucosa irritation. To this end, oral mucosa organ equivalent cultures (OMOEC) and skin equivalent cultures (SEC), both derived from human tissue, were evaluated for their responsiveness t ... Full text Cite

Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: analysis of common signal transduction pathways.

Journal Article Endocrinology · January 1994 In the testis the mesenchymally derived peritubular cells produce a paracrine factor, PModS, that mediates mesenchymal-epithelial interactions and modulates Sertoli cell functions essential for the process of spermatogenesis. PModS has a more dramatic effe ... Full text Link to item Cite

Regulation of Sertoli cell differentiation by the testicular paracrine factor PModS: potential role of immediate-early genes.

Journal Article Mol Endocrinol · December 1992 Testicular peritubular cells produce a paracrine factor, PModS, under androgen control that modulates Sertoli cell functions that are essential for the process of spermatogenesis. PModS has a more dramatic effect on Sertoli cell differentiated functions in ... Full text Link to item Cite

Total RNA isolation by a rapid centrifugation method.

Journal Article Am Biotechnol Lab · February 1992 Link to item Cite

Cell-cell interactions and the regulation of testis function.

Journal Article Ann N Y Acad Sci · 1991 Regulatory interactions have been shown to occur between all the testicular cell types considered. The paracrine factors mediating these interactions generally influence either cellular growth or differentiation. The regulation of cellular growth is essent ... Full text Link to item Cite

Regulation of Sertoli cell function and differentiation through the actions of a testicular paracrine factor P-Mod-S.

Journal Article Endocrinology · June 1989 The current study was designed to investigate the actions of the testicular paracrine factor P-Mod-S on Sertoli cell function and differentiation. Transferrin production by Sertoli cells was stimulated by P-Mod-S to a greater extent than any individual reg ... Full text Link to item Cite