Overview
Jonathan P. Piccini, MD, MHS, FACC, FAHA, FHRS is a clinical cardiac electrophysiologist and Professor of Medicine and Population Health at Duke University Hospital and the Duke Clinical Research Institute. He is the Director of the Cardiac Electrophysiology section at the Duke Heart Center. His focus is on the care of patients with atrial fibrillation and complex arrhythmias, with particular emphasis on catheter ablation, pacing, and lead extraction. His research interests include the development and evaluation of innovative cardiovascular interventions for the treatment of heart rhythm disorders. He serves on the Board of Trustees of the Heart Rhythm Society, is an Associate Editor at JACC: Clinical Electrophysiology, and is an elected member of the American Society for Clinical Investigation. Dr. Piccini has more than 600 publications in the field of heart rhythm medicine and has been the recipient of several teaching and mentorship awards.
Current Appointments & Affiliations
Recent Publications
Pulsed Field Ablation for the Interventional Treatment of Atrial Fibrillation. A Scientific Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), the Latin American Heart Rhythm Society (LAHRS) and the Canadian Heart Rhythm Society (CHRS).
Journal Article Europace · April 12, 2026 Pulsed field ablation has emerged as a novel non-thermal treatment modality with a distinct safety profile for the interventional treatment of atrial fibrillation. By inducing irreversible electroporation, pulsed field ablation achieves myocardial ablation ... Full text Link to item CitePatient Care Pathways and Outcomes Following Newly Diagnosed Atrial Fibrillation.
Journal Article J Am Heart Assoc · March 31, 2026 BACKGROUND: Care pathways for patients with atrial fibrillation (AF) are poorly understood and may influence the likelihood of guideline concordant oral anticoagulation or antiarrhythmic drug therapy and associated outcomes. METHODS: Adult patients in the ... Full text Link to item CiteLeft atrial appendage occlusion and concomitant catheter ablation procedures.
Journal Article Heart Rhythm · March 10, 2026 BACKGROUND: The safety and effectiveness of concomitant catheter ablation at the time of left atrial appendage (LAA) occlusion (LAAO) are not well characterized. OBJECTIVE: This study aimed to describe the safety and effectiveness of LAAO during concomitan ... Full text Link to item CiteRecent Grants
A randomized, placebo-controlled, participant-and investigator-blinded study to evaluate the efficacy in reducing atrial fibrillation burden (AFB) as well as the safety, tolerability, and pharmacokinetics of oral PKN605 in participants
Clinical TrialPrincipal Investigator · Awarded by Novartis Pharmaceuticals Corporation · 2025 - 2029Duke Lead Extraction Course
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by Philips Image Guided Therapy Corporation · 2024 - 2027Safety and Effectiveness Evaluation of the THERMOCOOL SMARTTOUCH¿ SF Catheter with the TRUPULSE¿ Generator for treatment of drug refractory symptomatic Paroxysmal Atrial Fibrillation (PAF)
Clinical TrialPrincipal Investigator · Awarded by Biosense Webster Inc · 2024 - 2027View All Grants