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Jonathan Paul Piccini Sr.

Professor of Medicine
Medicine, Cardiology
Duke Box 31115, Durham, NC 27710
Dept of Medicine, Durham, NC 27710

Overview


Jonathan P. Piccini, MD, MHS, FACC, FAHA, FHRS is a clinical cardiac electrophysiologist and Professor of Medicine and Population Health at Duke University Hospital and the Duke Clinical Research Institute. He is the Director of the Cardiac Electrophysiology section at the Duke Heart Center. His focus is on the care of patients with atrial fibrillation and complex arrhythmias, with particular emphasis on catheter ablation, pacing, and lead extraction. His research interests include the development and evaluation of innovative cardiovascular interventions for the treatment of heart rhythm disorders. He serves on the Board of Trustees of the Heart Rhythm Society, is an Associate Editor at JACC: Clinical Electrophysiology, and is an elected member of the American Society for Clinical Investigation. Dr. Piccini has more than 600 publications in the field of heart rhythm medicine and has been the recipient of several teaching and mentorship awards.

Current Appointments & Affiliations


Professor of Medicine · 2022 - Present Medicine, Cardiology, Medicine
Director, Cardiac Electrophysiology Section · 2019 - Present Medicine, Cardiology, Medicine
Professor in Population Health Sciences · 2022 - Present Population Health Sciences, Basic Science Departments
Member in the Duke Clinical Research Institute · 2010 - Present Duke Clinical Research Institute, Institutes and Centers

In the News


Published November 17, 2017
Botulinum Toxin for Atrial Fibrillation? Maybe, But More Study is Needed
Published March 29, 2016
Wearable defibrillator may help some heart patients

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Recent Publications


Factor XI inhibitors for the prevention and treatment of venous and arterial thromboembolism.

Journal Article Nat Rev Cardiol · November 2025 Therapeutic anticoagulation is essential to prevent and treat venous and arterial thromboembolism. The available agents target coagulation factors involved in thrombus formation but are associated with an increased risk of bleeding. Factor XI plays a minor ... Full text Link to item Cite

Microbubble and thermal profile of an eight-spline pulsed field ablation system in a pre-clinical model.

Journal Article J Interv Card Electrophysiol · October 16, 2025 BACKGROUND: Pulsed field ablation (PFA) has become a clinically accepted energy modality for catheter ablation of atrial fibrillation. As PFA catheters improve and evolve, iatrogenic cerebral events remain an important consideration when evaluating the saf ... Full text Link to item Cite
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Recent Grants


Duke Lead Extraction Course

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by Philips Image Guided Therapy Corporation · 2024 - 2027

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Education, Training & Certifications


Duke University · 2009 M.H.S.
Northwestern University, Feinberg School of Medicine · 2002 M.D.