Overview
Jonathan P. Piccini, MD, MHS, FACC, FAHA, FHRS is a clinical cardiac electrophysiologist and Professor of Medicine and Population Health at Duke University Hospital and the Duke Clinical Research Institute. He is the Director of the Cardiac Electrophysiology section at the Duke Heart Center. His focus is on the care of patients with atrial fibrillation and complex arrhythmias, with particular emphasis on catheter ablation, pacing, and lead extraction. His research interests include the development and evaluation of innovative cardiovascular interventions for the treatment of heart rhythm disorders. He serves on the Board of Trustees of the Heart Rhythm Society, is an Associate Editor at JACC: Clinical Electrophysiology, and is an elected member of the American Society for Clinical Investigation. Dr. Piccini has more than 600 publications in the field of heart rhythm medicine and has been the recipient of several teaching and mentorship awards.
Current Appointments & Affiliations
Recent Publications
Factor XI inhibitors for the prevention and treatment of venous and arterial thromboembolism.
Journal Article Nat Rev Cardiol · November 2025 Therapeutic anticoagulation is essential to prevent and treat venous and arterial thromboembolism. The available agents target coagulation factors involved in thrombus formation but are associated with an increased risk of bleeding. Factor XI plays a minor ... Full text Link to item CiteMicrobubble and thermal profile of an eight-spline pulsed field ablation system in a pre-clinical model.
Journal Article J Interv Card Electrophysiol · October 16, 2025 BACKGROUND: Pulsed field ablation (PFA) has become a clinically accepted energy modality for catheter ablation of atrial fibrillation. As PFA catheters improve and evolve, iatrogenic cerebral events remain an important consideration when evaluating the saf ... Full text Link to item CiteResponse by Fauchier et al to Letter Regarding Article, "Incidence, Prevalence, and Trends in Mortality and Stroke Among Medicare Beneficiaries With Atrial Fibrillation: 2013 to 2019".
Journal Article Circ Cardiovasc Qual Outcomes · October 9, 2025 Full text Link to item CiteRecent Grants
Duke Lead Extraction Course
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by Philips Image Guided Therapy Corporation · 2024 - 2027Safety and Effectiveness Evaluation of the THERMOCOOL SMARTTOUCH¿ SF Catheter with the TRUPULSE¿ Generator for treatment of drug refractory symptomatic Paroxysmal Atrial Fibrillation (PAF)
Clinical TrialPrincipal Investigator · Awarded by Biosense Webster Inc · 2024 - 2027CRD 1074 FlexPulse - Safety and effectiveness of the TactiFlex SE Catheter and Volt Pulsed Field Ablation (PFA) Generator in subjects with paroxysmal atrial fibrillation
Clinical TrialPrincipal Investigator · Awarded by St. Jude Medical Business Services Inc. · 2024 - 2026View All Grants