Overview
Jonathan P. Piccini, MD, MHS, FACC, FAHA, FHRS is a clinical cardiac electrophysiologist and Professor of Medicine and Population Health at Duke University Hospital and the Duke Clinical Research Institute. He is the Director of the Cardiac Electrophysiology section at the Duke Heart Center. His focus is on the care of patients with atrial fibrillation and complex arrhythmias, with particular emphasis on catheter ablation, pacing, and lead extraction. His research interests include the development and evaluation of innovative cardiovascular interventions for the treatment of heart rhythm disorders. He serves on the Board of Trustees of the Heart Rhythm Society, is an Associate Editor at JACC: Clinical Electrophysiology, and is an elected member of the American Society for Clinical Investigation. Dr. Piccini has more than 600 publications in the field of heart rhythm medicine and has been the recipient of several teaching and mentorship awards.
Current Appointments & Affiliations
Recent Publications
Atrial fibrillation ablation in heart failure with preserved ejection fraction: Who might be a "responder" and a "non-responder"?
Journal Article Heart Rhythm · January 2026 Full text Link to item CiteManagement of atrial fibrillation in patients with heart failure with preserved ejection fraction.
Journal Article Heart Fail Rev · December 2025 Atrial fibrillation (AF) and heart failure with a preserved ejection fraction (HFpEF) frequently co-exist and are associated with high cardiovascular morbidity and mortality. The management of AF in HFpEF requires a multifaceted and integrated approach tha ... Full text Link to item CiteResponse by Rogovoy et al to Letter Regarding Article, "Incidence, Prevalence, and Trends in Mortality and Stroke Among Medicare Beneficiaries With Atrial Fibrillation: 2013 to 2019".
Journal Article Circ Cardiovasc Qual Outcomes · December 2025 Full text Link to item CiteRecent Grants
Duke Lead Extraction Course
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by Philips Image Guided Therapy Corporation · 2024 - 2027Safety and Effectiveness Evaluation of the THERMOCOOL SMARTTOUCH¿ SF Catheter with the TRUPULSE¿ Generator for treatment of drug refractory symptomatic Paroxysmal Atrial Fibrillation (PAF)
Clinical TrialPrincipal Investigator · Awarded by Biosense Webster Inc · 2024 - 2027CRD 1074 FlexPulse - Safety and effectiveness of the TactiFlex SE Catheter and Volt Pulsed Field Ablation (PFA) Generator in subjects with paroxysmal atrial fibrillation
Clinical TrialPrincipal Investigator · Awarded by St. Jude Medical Business Services Inc. · 2024 - 2026View All Grants