Journal ArticleNeurobiol Aging · October 2018
The link between age-related cellular changes within brain regions and larger scale neuronal ensemble dynamics critical for cognition has not been fully elucidated. The present study measured neuron activity within medial prefrontal cortex (PFC), perirhina ...
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Journal ArticleFrontiers in Systems Neuroscience · June 30, 2017
Age-related memory deficits correlate with dysfunction in the CA3 subregion of the hippocampus, which includes both hyperactivity and overly rigid activity patterns. While changes in intrinsic membrane currents and interneuron alterations are involved in t ...
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Journal ArticleNeurobiol Learn Mem · January 2017
The ability to use information from the physical world to update behavioral strategies is critical for survival across species. The prefrontal cortex (PFC) supports behavioral flexibility; however, exactly how this brain structure interacts with sensory as ...
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Journal ArticleBehav Neurosci · October 2015
Age-associated cognitive decline can reduce an individual's quality of life. As no single neurobiological deficit can account for the wide spectrum of behavioral impairments observed in old age, it is critical to develop an understanding of how interaction ...
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