Overview
Infectious diseases remain one of the leading causes of morbidity and mortality in the United States and worldwide. The Coers lab seeks to understand fundamental aspects of the immune response to microbes as well as the corresponding immune evasion strategies evolved by human pathogens to undermine immunity and establish infections. Defining human immunity and microbial counter-immunity pathways on a molecular level will provide roadmaps for the rational design of novel antimicrobial therapies and improved vaccine strategies against human pathogens such as the enteric bacterial pathogen Shigella or the sexually transmitted bacterial pathogen Chlamydia.
In addition to making major inroads in the fields of immunity, inflammation and microbial pathogenesis, our second, but equally important goal, is to train the next generation of scientists in an environment that prioritizes excellence, research integrity, learning opportunities, and teamwork. We strive to create an environment of mutual respect, openness, collegiality, integrity and, last but not least, fun, which promotes and awards curiosity and fosters collaborations.
Current Appointments & Affiliations
Recent Publications
The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation.
Journal Article Elife · November 28, 2025 A central signal that marshals host defense against many infections is the lymphocyte-derived cytokine interferon-gamma (IFNγ). The IFNγ receptor is expressed on most human cells, and its activation leads to the expression of antimicrobial proteins that ex ... Full text Link to item CiteThe Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation.
Journal Article bioRxiv · July 30, 2025 A central signal that marshals host defense against many infections is the lymphocyte-derived cytokine interferon-gamma (IFNγ). The IFNγ receptor is expressed on most human cells, and its activation leads to the expression of antimicrobial proteins that ex ... Full text Link to item CiteGuanylate-Binding Proteins Promote Host Defense Against Leishmania major by Balancing iNOS/Arg-1 in Myeloid Cells.
Journal Article bioRxiv · June 30, 2025 Cutaneous leishmaniasis (CL) is a debilitating neglected tropical disease characterized by lesions that can range from self-healing to permanent disfigurations. A predominant Th1 response, which stimulates IFN-γ production, is crucial for parasite control ... Full text Link to item CiteRecent Grants
Innate immune defenses against a cytosolic capsule
ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2030Interferon-inducible cell-intrinsic host defense against Chlamydia trachomatis
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2028Interferon-inducible cell-autonomous immunity to cytosolic bacterial pathogens
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2028View All Grants