Jorn Coers
Associate Professor in Molecular Genetics and Microbiology
Bacterial infections remain one of the leading causes of morbidity and mortality worldwide. The Coers lab seeks to understand fundamental aspects of the innate immune response to bacterial pathogens as well as the corresponding immune evasion strategies evolved by human pathogens undermining immunity in order to establish infections. Defining innate immunity and microbial counter-immunity pathways on a molecular level will provide roadmaps for the rational design of novel antimicrobial therapies and improved vaccine strategies against pathogens such as the enteric pathogen Shigella or the sexually transmitted pathogen Chlamydia.
In addition to making major inroads in the fields of innate immunity, inflammation and bacterial pathogenesis, our second, but equally important goal, is to train the next generation of scientists in an environment that prioritizes excellence, research integrity, teamwork and inclusiveness. We strive to create an environment of mutual respect, openness, collegiality, integrity and, last but not least, fun, which promotes and awards curiosity and fosters collaborations. We strongly believe that diversity promotes excellence.
Current Appointments & Affiliations
- Associate Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2018
- Associate Professor of Immunology, Immunology, Basic Science Departments 2019
- Associate Professor, Cell Biology, Basic Science Departments 2022
Contact Information
- Background
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Education, Training, & Certifications
- Ph.D., University of Basel (Switzerland) 2004
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Previous Appointments & Affiliations
- Assistant Professor of Immunology, Immunology, Basic Science Departments 2010 - 2019
- Assistant Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2010 - 2018
- Recognition
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In the News
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NOV 9, 2022 -
SEP 8, 2022 -
JUN 30, 2016 -
JUN 30, 2016 Duke Today -
SEP 28, 2015 -
SEP 28, 2015 Duke Today
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Awards & Honors
- Investigator in the Pathogenesis of Infectious Disease . Burroughs Wellcome Fund . 2016
- ICAAC Young Investigator Awards. American Society for Microbiology. 2011
- SERCEB Career Development Award. NIAID. 2011
- Jane E. Raulston Award . Chlamydia Basic Research Society . 2009
- Charles A. King trust postdoctoral fellowsh. Health Resources in Action. 2007
- Research
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Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Basic Immunology Training Program awarded by National Institutes of Health 2020 - 2025
- IRGM proteins as regulators of inflammation awarded by National Institutes of Health 2020 - 2025
- Interferon-inducible cell-intrinsic host defense against Chlamydia trachomatis awarded by National Institutes of Health 2019 - 2024
- Human GBPs in cell-autonomous immunity to intracellular bacterial pathogens awarded by National Institutes of Health 2019 - 2023
- Genetic analysis of mechanisms of chlamydial immune evasion awarded by Indiana University 2012 - 2023
- Defining human interferon-stimulated genes with novel functions in host defense to Chlamydia infections awarded by National Institutes of Health 2020 - 2023
- Host-mediated lysis of cytoplasmic pathogens awarded by Burroughs Wellcome Fund 2016 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Interspecies chimera libraries to define host specific adaptations by Chlamydia awarded by University of Washington 2020 - 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Human GBPs in cell-autonomous immunity to intracellular bacterial pathogens awarded by National Institutes of Health 2018 - 2019
- Interferon-driven ubiquitin response targets Chlamydia inclusions in human cells awarded by National Institutes of Health 2017 - 2019
- Innate immune recognition of pathogen-containing vacuoles by GBPs awarded by National Institutes of Health 2016 - 2018
- Targeting of Interferon-induced host proteins to Legionella-containing vacuoles awarded by National Institutes of Health 2012 - 2015
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External Relationships
- FEMS federation european microbiological societies editor in chief for FEMS Pathogens and Disease
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Wilburn, Kaley M., Rachel K. Meade, Emma M. Heckenberg, Jacob Dockterman, Jörn Coers, Christopher M. Sassetti, Andrew J. Olive, and Clare M. Smith. “Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice.” Infect Immun, January 11, 2023, e0051022. https://doi.org/10.1128/iai.00510-22.Full Text Link to Item
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Walsh, Stephen C., Jeffrey R. Reitano, Mary S. Dickinson, Miriam Kutsch, Dulcemaria Hernandez, Alyson B. Barnes, Benjamin H. Schott, et al. “The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction.” Cell Host Microbe 30, no. 12 (December 14, 2022): 1671-1684.e9. https://doi.org/10.1016/j.chom.2022.08.008.Full Text Link to Item
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Saelens, Joseph W., Mollie I. Sweeney, Gopinath Viswanathan, Ana María Xet-Mull, Kristen L. Jurcic Smith, Dana M. Sisk, Daniel D. Hu, et al. “An ancestral mycobacterial effector promotes dissemination of infection.” Cell 185, no. 24 (November 23, 2022): 4507-4525.e18. https://doi.org/10.1016/j.cell.2022.10.019.Full Text Link to Item
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Hernandez, Dulcemaria, Stephen Walsh, Luz Saavedra Sanchez, Mary S. Dickinson, and Jörn Coers. “Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous Vacuoles.” Mbio 13, no. 5 (October 26, 2022): e0188822. https://doi.org/10.1128/mbio.01888-22.Full Text Link to Item
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Dockterman, Jacob, and Jörn Coers. “How did we get here? Insights into mechanisms of immunity-related GTPase targeting to intracellular pathogens.” Curr Opin Microbiol 69 (October 2022): 102189. https://doi.org/10.1016/j.mib.2022.102189.Full Text Link to Item
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Maciag, Karolina, Raktima Raychowdhury, Karen Smith, Alexis M. Schneider, Jörn Coers, Maxwell R. Mumbach, Schraga Schwartz, and Nir Hacohen. “IRF3 inhibits IFN-γ-mediated restriction of intracellular pathogens in macrophages independently of IFNAR.” J Leukoc Biol 112, no. 2 (August 2022): 257–71. https://doi.org/10.1002/JLB.3A0218-069RR.Full Text Link to Item
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Moretti, Julien, Baosen Jia, Zachary Hutchins, Soumit Roy, Hilary Yip, Jiahui Wu, Meimei Shan, Samie R. Jaffrey, Jörn Coers, and J Magarian Blander. “Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome.” Nat Immunol 23, no. 5 (May 2022): 705–17. https://doi.org/10.1038/s41590-022-01192-4.Full Text Link to Item
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Dickinson, Mary S., and Jörn Coers. “SNX10 and caspase-5 sort out endosomal LPS for a gut-wrenching Slug-fest.” Embo J 40, no. 24 (December 15, 2021): e110128. https://doi.org/10.15252/embj.2021110128.Full Text Link to Item
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Coers, Jörn, Hayley J. Newton, and Jason A. Carlyon. “Can't live outside you: a thematic issue on obligate intracellular bacterial pathogens.” Pathog Dis 79, no. 9 (December 9, 2021). https://doi.org/10.1093/femspd/ftab054.Full Text Link to Item
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Dockterman, Jacob, Brian E. Fee, Gregory A. Taylor, and Jörn Coers. “Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii.” Infect Immun 89, no. 11 (October 15, 2021): e0020221. https://doi.org/10.1128/IAI.00202-21.Full Text Link to Item
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Kutsch, Miriam, and Jörn Coers. “Human guanylate binding proteins: nanomachines orchestrating host defense.” Febs J 288, no. 20 (October 2021): 5826–49. https://doi.org/10.1111/febs.15662.Full Text Link to Item
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Kutsch, Miriam, Coral González-Prieto, Cammie F. Lesser, and Jörn Coers. “The GBP1 microcapsule interferes with IcsA-dependent septin cage assembly around Shigella flexneri.” Pathog Dis 79, no. 5 (April 24, 2021). https://doi.org/10.1093/femspd/ftab023.Full Text Link to Item
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Dockterman, Jacob, and Jörn Coers. “Immunopathogenesis of genital Chlamydia infection: insights from mouse models.” Pathog Dis 79, no. 4 (March 31, 2021). https://doi.org/10.1093/femspd/ftab012.Full Text Link to Item
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Finethy, Ryan, Jacob Dockterman, Miriam Kutsch, Nichole Orench-Rivera, Graham D. Wallace, Anthony S. Piro, Sarah Luoma, et al. “Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock.” Embo Rep 21, no. 11 (November 5, 2020): e50830. https://doi.org/10.15252/embr.202050830.Full Text Link to Item
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Haldar, Arun Kumar, Utsav Nigam, Masahiro Yamamoto, Jörn Coers, and Neena Goyal. “Guanylate Binding Proteins Restrict Leishmania donovani Growth in Nonphagocytic Cells Independent of Parasitophorous Vacuolar Targeting.” Mbio 11, no. 4 (July 28, 2020). https://doi.org/10.1128/mBio.01464-20.Full Text Link to Item
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Kutsch, Miriam, Linda Sistemich, Cammie F. Lesser, Marcia B. Goldberg, Christian Herrmann, and Jörn Coers. “Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions.” Embo J 39, no. 13 (July 1, 2020): e104926. https://doi.org/10.15252/embj.2020104926.Full Text Link to Item
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Kohler, Kristin M., Miriam Kutsch, Anthony S. Piro, Graham D. Wallace, Jörn Coers, and Matthew F. Barber. “A Rapidly Evolving Polybasic Motif Modulates Bacterial Detection by Guanylate Binding Proteins.” Mbio 11, no. 3 (May 19, 2020). https://doi.org/10.1128/mBio.00340-20.Full Text Link to Item
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Finethy, Ryan, Jacob Dockterman, Miriam Kutsch, Nichole Orench-Rivera, Graham Wallace, Anthony Piro, Sarah Luoma, et al. “Dynamin-related Irgm proteins modulate LPS-induced caspase-4 activation and septic shock,” 2020. https://doi.org/10.1101/2020.03.18.997460.Full Text Open Access Copy
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Price, Jordan V., Daniel Russo, Daisy X. Ji, Roberto A. Chavez, Lucian DiPeso, Angus Yiu-Fai Lee, Jörn Coers, and Russell E. Vance. “IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila.” Mbio 10, no. 6 (November 12, 2019). https://doi.org/10.1128/mBio.02629-19.Full Text Link to Item
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Giebel, Amanda M., Shuai Hu, Krithika Rajaram, Ryan Finethy, Evelyn Toh, Julie A. Brothwell, Sandra G. Morrison, et al. “Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture.” Mbio 10, no. 2 (April 9, 2019). https://doi.org/10.1128/mBio.00385-19.Full Text Open Access Copy Link to Item
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Huston, Wilhelmina M., Jörn Coers, and Alfredo Garzino-Demo. “Fresh faces and new approaches at Pathogens and Disease.” Pathog Dis 77, no. 1 (February 1, 2019). https://doi.org/10.1093/femspd/ftz010.Full Text Link to Item
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Clough, Barbara, Ryan Finethy, Rabia T. Khan, Daniel Fisch, Sarah Jordan, Harshil Patel, Jörn Coers, and Eva-Maria Frickel. “C57BL/6 and 129 inbred mouse strains differ in Gbp2 and Gbp2b expression in response to inflammatory stimuli in vivo.” Wellcome Open Res 4 (2019): 124. https://doi.org/10.12688/wellcomeopenres.15329.1.Full Text Link to Item
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Ajayi, Teminioluwa A., Cynthia L. Innes, Sara A. Grimm, Prashant Rai, Ryan Finethy, Jörn Coers, Xuting Wang, et al. “Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues.” Am J Physiol Gastrointest Liver Physiol 316, no. 1 (January 1, 2019): G95–105. https://doi.org/10.1152/ajpgi.00196.2018.Full Text Link to Item
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Kohler, Kristin, Miriam Kutsch, Anthony Piro, Graham Wallace, Jörn Coers, and Matthew Barber. “A rapidly evolving polybasic motif modulates bacterial detection by guanylate binding proteins,” 2019. https://doi.org/10.1101/689554.Full Text
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Price, Jordan, Daniel Russo, Daisy Ji, Roberto Chavez, Lucian DiPeso, Angus Yiu-Fai Lee, Jörn Coers, and Russell Vance. “IRG1 and iNOS act redundantly with other interferon gamma-induced factors to restrict intracellular replication ofLegionella pneumophila,” 2019. https://doi.org/10.1101/731182.Full Text
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Coers, Jörn, Hailey M. Brown, Seungmin Hwang, and Gregory A. Taylor. “Partners in anti-crime: how interferon-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense.” Curr Opin Immunol 54 (October 2018): 93–101. https://doi.org/10.1016/j.coi.2018.06.008.Full Text Link to Item
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Liu, Beiyun C., Joseph Sarhan, Alexander Panda, Hayley I. Muendlein, Vladimir Ilyukha, Jörn Coers, Masahiro Yamamoto, Ralph R. Isberg, and Alexander Poltorak. “Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses.” Cell Rep 24, no. 1 (July 3, 2018): 155-168.e5. https://doi.org/10.1016/j.celrep.2018.06.012.Full Text Link to Item
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Piro, Anthony S., Dulcemaria Hernandez, Sarah Luoma, Eric M. Feeley, Ryan Finethy, Azeb Yirga, Eva M. Frickel, Cammie F. Lesser, and Jörn Coers. “Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility.” Mbio 8, no. 6 (December 12, 2017). https://doi.org/10.1128/mBio.01979-17.Full Text Link to Item
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Coers, Jörn. “Sweet host revenge: Galectins and GBPs join forces at broken membranes.” Cell Microbiol 19, no. 12 (December 2017). https://doi.org/10.1111/cmi.12793.Full Text Link to Item
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Finethy, Ryan, Sarah Luoma, Nichole Orench-Rivera, Eric M. Feeley, Arun K. Haldar, Masahiro Yamamoto, Thirumala-Devi Kanneganti, Meta J. Kuehn, and Jörn Coers. “Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins.” Mbio 8, no. 5 (October 3, 2017). https://doi.org/10.1128/mBio.01188-17.Full Text Open Access Copy Link to Item
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Zwack, Erin E., Eric M. Feeley, Amanda R. Burton, Baofeng Hu, Masahiro Yamamoto, Thirumala-Devi Kanneganti, James B. Bliska, Jörn Coers, and Igor E. Brodsky. “Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components.” Infect Immun 85, no. 10 (October 2017). https://doi.org/10.1128/IAI.00778-16.Full Text Link to Item
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Biering, Scott B., Jayoung Choi, Rachel A. Halstrom, Hailey M. Brown, Wandy L. Beatty, Sanghyun Lee, Broc T. McCune, et al. “Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases.” Cell Host Microbe 22, no. 1 (July 12, 2017): 74-85.e7. https://doi.org/10.1016/j.chom.2017.06.005.Full Text Link to Item
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Schmidt, Elyse A., Brian E. Fee, Stanley C. Henry, Amanda G. Nichols, Mari L. Shinohara, Jeffrey C. Rathmell, Nancie J. MacIver, et al. “Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages.” J Biol Chem 292, no. 11 (March 17, 2017): 4651–62. https://doi.org/10.1074/jbc.M116.770735.Full Text Link to Item
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Feeley, Eric M., Danielle M. Pilla-Moffett, Erin E. Zwack, Anthony S. Piro, Ryan Finethy, Joseph P. Kolb, Jennifer Martinez, Igor E. Brodsky, and Jörn Coers. “Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems.” Proc Natl Acad Sci U S A 114, no. 9 (February 28, 2017): E1698–1706. https://doi.org/10.1073/pnas.1615771114.Full Text Link to Item
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Piro, Anthony, Dulcemaria Hernandez, Sarah Luoma, Eric Feeley, Ryan Finethy, Azeb Yirga, Eva Frickel, Cammie Lesser, and Jörn Coers. “Detection of cytosolicShigella flexnerivia a C-terminal triple-arginine motif of GBP1 inhibits actin-based motility,” 2017. https://doi.org/10.1101/212175.Full Text
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Sixt, Barbara S., Robert J. Bastidas, Ryan Finethy, Ryan M. Baxter, Victoria K. Carpenter, Guido Kroemer, Jörn Coers, and Raphael H. Valdivia. “The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs.” Cell Host & Microbe 21, no. 1 (January 2017): 113–21. https://doi.org/10.1016/j.chom.2016.12.002.Full Text
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Haldar, Arun K., Anthony S. Piro, Ryan Finethy, Scott T. Espenschied, Hannah E. Brown, Amanda M. Giebel, Eva-Maria Frickel, David E. Nelson, and Jörn Coers. “Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells.” Mbio 7, no. 6 (December 13, 2016). https://doi.org/10.1128/mBio.01417-16.Full Text Link to Item
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Finethy, Ryan, and Jörn Coers. “Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis.” Fems Microbiol Rev 40, no. 6 (November 1, 2016): 875–93. https://doi.org/10.1093/femsre/fuw027.Full Text Link to Item
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Pensinger, Daniel A., Kyle M. Boldon, Grischa Y. Chen, William J. B. Vincent, Kyle Sherman, Meng Xiong, Adam J. Schaenzer, et al. “The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence.” Plos Pathog 12, no. 11 (November 2016): e1006001. https://doi.org/10.1371/journal.ppat.1006001.Full Text Link to Item
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Pilla-Moffett, Danielle, Matthew F. Barber, Gregory A. Taylor, and Jörn Coers. “Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease.” J Mol Biol 428, no. 17 (August 28, 2016): 3495–3513. https://doi.org/10.1016/j.jmb.2016.04.032.Full Text Link to Item
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Johnston, Ashleigh C., Anthony Piro, Barbara Clough, Malvin Siew, Sebastian Virreira Winter, Jörn Coers, and Eva-Maria Frickel. “Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii.” Cell Microbiol 18, no. 8 (August 2016): 1056–64. https://doi.org/10.1111/cmi.12579.Full Text Link to Item
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Finethy, Ryan, and Jörn Coers. “Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis.” Fems Microbiol Rev, July 29, 2016. https://doi.org/10.1093/femsre/fuw027.Full Text Link to Item
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“Erratum.” Autophagy 12, no. 2 (2016): 443. https://doi.org/10.1080/15548627.2016.1147886.Full Text Link to Item
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Finethy, Ryan, Ine Jorgensen, Arun K. Haldar, Marcel R. de Zoete, Till Strowig, Richard A. Flavell, Masahiro Yamamoto, Uma M. Nagarajan, Edward A. Miao, and Jörn Coers. “Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.” Infect Immun 83, no. 12 (December 2015): 4740–49. https://doi.org/10.1128/IAI.00856-15.Full Text Link to Item
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Aachoui, Youssef, Yuji Kajiwara, Irina A. Leaf, Dat Mao, Jenny P-Y Ting, Jörn Coers, Alan Aderem, Joseph D. Buxbaum, and Edward A. Miao. “Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.” Cell Host Microbe 18, no. 3 (September 9, 2015): 320–32. https://doi.org/10.1016/j.chom.2015.07.016.Full Text Link to Item
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Coers, Jörn, and Arun K. Haldar. “Ubiquitination of pathogen-containing vacuoles promotes host defense to Chlamydia trachomatis and Toxoplasma gondii.” Commun Integr Biol 8, no. 6 (2015): e1115163. https://doi.org/10.1080/19420889.2015.1115163.Full Text Link to Item
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Pilla, Danielle M., Jon A. Hagar, Arun K. Haldar, Ashley K. Mason, Daniel Degrandi, Klaus Pfeffer, Robert K. Ernst, Masahiro Yamamoto, Edward A. Miao, and Jörn Coers. “Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.” Proc Natl Acad Sci U S A 111, no. 16 (April 22, 2014): 6046–51. https://doi.org/10.1073/pnas.1321700111.Full Text Link to Item
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Furuse, Yuki, Ryan Finethy, Hector A. Saka, Ana M. Xet-Mull, Dana M. Sisk, Kristen L Jurcic Smith, Sunhee Lee, et al. “Search for microRNAs expressed by intracellular bacterial pathogens in infected mammalian cells.” Plos One 9, no. 9 (2014): e106434. https://doi.org/10.1371/journal.pone.0106434.Full Text Open Access Copy Link to Item
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Haldar, Arun K., Anthony S. Piro, Danielle M. Pilla, Masahiro Yamamoto, and Jörn Coers. “The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.” Plos One 9, no. 1 (2014): e86684. https://doi.org/10.1371/journal.pone.0086684.Full Text Link to Item
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Coers, Jörn. “Self and non-self discrimination of intracellular membranes by the innate immune system.” Plos Pathog 9, no. 9 (September 2013): e1003538. https://doi.org/10.1371/journal.ppat.1003538.Full Text Link to Item
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Traver, M. K., S. C. Henry, V. Cantillana, T. Oliver, J. P. Hunn, J. C. Howard, S. Beer, K. Pfeffer, J. Coers, and G. A. Taylor. “Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.” J Biol Chem 288, no. 16 (April 19, 2013): 11504. https://doi.org/10.1074/jbc.A111.251967.Full Text Link to Item
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Haldar, Arun K., Hector A. Saka, Anthony S. Piro, Joe Dan Dunn, Stanley C. Henry, Gregory A. Taylor, Eva M. Frickel, Raphael H. Valdivia, and Jörn Coers. “IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins.” Plos Pathog 9, no. 6 (2013): e1003414. https://doi.org/10.1371/journal.ppat.1003414.Full Text Link to Item
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Traver, Maria K., Stanley C. Henry, Viviana Cantillana, Tim Oliver, Julia P. Hunn, Jonathan C. Howard, Sandra Beer, Klaus Pfeffer, Jörn Coers, and Gregory A. Taylor. “Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.” J Biol Chem 286, no. 35 (September 2, 2011): 30471–80. https://doi.org/10.1074/jbc.M111.251967.Full Text Link to Item
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Coers, Jörn, Dave C. Gondek, Andrew J. Olive, Amy Rohlfing, Gregory A. Taylor, and Michael N. Starnbach. “Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections.” Plos Pathog 7, no. 6 (June 2011): e1001346. https://doi.org/10.1371/journal.ppat.1001346.Full Text Link to Item
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Khaminets, Aliaksandr, Julia P. Hunn, Stephanie Könen-Waisman, Yang O. Zhao, Daniela Preukschat, Jörn Coers, Jon P. Boyle, et al. “Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.” Cell Microbiol 12, no. 7 (July 2010): 939–61. https://doi.org/10.1111/j.1462-5822.2010.01443.x.Full Text Link to Item
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Coers, Jörn, Michael N. Starnbach, and Jonathan C. Howard. “Modeling infectious disease in mice: co-adaptation and the role of host-specific IFNgamma responses.” Plos Pathog 5, no. 5 (May 2009): e1000333. https://doi.org/10.1371/journal.ppat.1000333.Full Text Link to Item
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Henry, Stanley C., Xiaoju G. Daniell, Ashley R. Burroughs, Maanasa Indaram, David N. Howell, Jörn Coers, Michael N. Starnbach, et al. “Balance of Irgm protein activities determines IFN-gamma-induced host defense.” J Leukoc Biol 85, no. 5 (May 2009): 877–85. https://doi.org/10.1189/jlb.1008599.Full Text Link to Item
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Tiedt, Ralph, Jörn Coers, Sandra Ziegler, Adrian Wiestner, Hui Hao-Shen, Caroline Bornmann, Johannes Schenkel, et al. “Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes.” Blood 113, no. 8 (February 19, 2009): 1768–77. https://doi.org/10.1182/blood-2008-03-146084.Full Text Link to Item
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Coers, Jörn, Isaac Bernstein-Hanley, David Grotsky, Iana Parvanova, Jonathan C. Howard, Gregory A. Taylor, William F. Dietrich, and Michael N. Starnbach. “Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10.” J Immunol 180, no. 9 (May 1, 2008): 6237–45. https://doi.org/10.4049/jimmunol.180.9.6237.Full Text Link to Item
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Coers, Jörn, Russell E. Vance, Mary F. Fontana, and William F. Dietrich. “Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways.” Cell Microbiol 9, no. 10 (October 2007): 2344–57. https://doi.org/10.1111/j.1462-5822.2007.00963.x.Full Text Link to Item
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Bernstein-Hanley, Isaac, Jörn Coers, Zarine R. Balsara, Gregory A. Taylor, Michael N. Starnbach, and William F. Dietrich. “The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice.” Proc Natl Acad Sci U S A 103, no. 38 (September 19, 2006): 14092–97. https://doi.org/10.1073/pnas.0603338103.Full Text Link to Item
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Bernstein-Hanley, I., Z. R. Balsara, W. Ulmer, J. Coers, M. N. Starnbach, and W. F. Dietrich. “Genetic analysis of susceptibility to Chlamydia trachomatis in mouse.” Genes Immun 7, no. 2 (March 2006): 122–29. https://doi.org/10.1038/sj.gene.6364285.Full Text Link to Item
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Coers, Jörn, Christina Ranft, and Radek C. Skoda. “A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation.” J Biol Chem 279, no. 35 (August 27, 2004): 36397–404. https://doi.org/10.1074/jbc.M401386200.Full Text Link to Item
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Kralovics, Robert, Andreas S. Buser, Soon-Siong Teo, Jorn Coers, Andre Tichelli, Anthonie P. C. van der Maas, and Radek C. Skoda. “Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders.” Blood 102, no. 5 (September 1, 2003): 1869–71. https://doi.org/10.1182/blood-2003-03-0744.Full Text Link to Item
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Coers, J., J. C. Kagan, M. Matthews, H. Nagai, D. M. Zuckman, and C. R. Roy. “Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth.” Mol Microbiol 38, no. 4 (November 2000): 719–36. https://doi.org/10.1046/j.1365-2958.2000.02176.x.Full Text Link to Item
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Roy, C. R., and J. Coers. “Exploitation of macrophages as a replication niche by Legionella pneumophila: response.” Trends Microbiol 8, no. 2 (February 2000): 49–50. https://doi.org/10.1016/s0966-842x(99)01673-x.Full Text Link to Item
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Coers, J., C. Monahan, and C. R. Roy. “Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth.” Nat Cell Biol 1, no. 7 (November 1999): 451–53. https://doi.org/10.1038/15687.Full Text Link to Item
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Other Articles
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Klionsky, Daniel J., Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).” Autophagy, 2016. https://doi.org/10.1080/15548627.2015.1100356.Full Text Link to Item
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Conference Papers
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Maciag, K., R. Raychowdhury, K. Smith, A. M. Schneider, J. Coers, M. R. Mumbach, S. Schwartz, and N. Hacohen. “IRF3 inhibits IFN-γ-mediated restriction of intracellular pathogens in macrophages independently of IFNAR.” In Journal of Leukocyte Biology, 112:257–71, 2022. https://doi.org/10.1002/JLB.3A0218-069RR.Full Text
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Feeley, E. M., D. Pilla-Moffett, A. Piro, R. Finethy, and J. Coers. “GALECTIN 3 FACILITATES RECRUITMENT OF THE GUANYLATE BINDING PROTEINS TO THE PATHOGEN CONTAINING VACUOLE.” In Cytokine, 87:87–87. ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2016.Link to Item
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Finethy, R., A. Piro, A. Haldar, G. Taylor, and J. Coers. “IMMUNITY RELATED GTPASES CONTROL CASPASE-11 ACTIVITY TO PROTECT AGAINST SEPTIC SHOCK.” In Cytokine, 87:122–122. ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2016.Link to Item
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Coers, Jörn. “ID: 260.” In Cytokine, 76:112–112. Elsevier BV, 2015. https://doi.org/10.1016/j.cyto.2015.08.256.Full Text
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Haldar, Arun K., Clémence Foltz, Ryan Finethy, Anthony S. Piro, Eric M. Feeley, Danielle M. Pilla-Moffett, Masaki Komatsu, Eva-Maria Frickel, and Jörn Coers. “Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins.” In Proc Natl Acad Sci U S A, 112:E5628–37, 2015. https://doi.org/10.1073/pnas.1515966112.Full Text Link to Item
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Coers, Joern, Isaac Berstein-Hanley, Zarine R. Balsara, Michael N. Starnbach, and William F. Dietrich. “Intracellular host defense to Chlamydia trachomatis infections is mediated by IFNgamma-inducible p47 (IRG) GTPases in mice.” In Journal of Immunology, 176:S108–S108. AMER ASSOC IMMUNOLOGISTS, 2006.Link to Item
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Coers, J., C. Ranft, S. Ziegler, and R. Skoda. “Inhibitory effect of a truncated form of c-MPL on TPO-dependent cell survival and proliferation.” In Experimental Hematology, 31:79–79. ELSEVIER SCIENCE INC, 2003.Link to Item
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Preprints
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Wilburn, Kaley M., Rachel K. Meade, Emma M. Heckenberg, Jacob Dockterman, Jörn Coers, Christopher M. Sassetti, Andrew J. Olive, and Clare M. Smith. “Differential requirement for IRGM proteins during tuberculosis infection in mice.” Cold Spring Harbor Laboratory, November 9, 2022. https://doi.org/10.1101/2022.11.09.515519.Full Text
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- Teaching & Mentoring
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Recent Courses
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