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Jorn Coers

Alter Geller Distinguished Professor for Research in Immunology
Molecular Genetics and Microbiology

Overview


Infectious diseases remain one of the leading causes of morbidity and mortality in the United States and worldwide. The Coers lab seeks to understand fundamental aspects of the immune response to microbes as well as the corresponding immune evasion strategies evolved by human pathogens to undermine immunity and establish infections. Defining human immunity and microbial counter-immunity pathways on a molecular level will provide roadmaps for the rational design of novel antimicrobial therapies and improved vaccine strategies against human pathogens such as the enteric bacterial pathogen Shigella or the sexually transmitted bacterial pathogen Chlamydia.

In addition to making major inroads in the fields of immunity, inflammation and microbial pathogenesis, our second, but equally important goal, is to train the next generation of scientists in an environment that prioritizes excellence, research integrity, learning opportunities, and teamwork. We strive to create an environment of mutual respect, openness, collegiality, integrity and, last but not least, fun, which promotes and awards curiosity and fosters collaborations.

Current Duke Appointments & Affiliations


Alter Geller Distinguished Professor for Research in Immunology · 2026 - Present Molecular Genetics and Microbiology, Basic Science Departments
Professor in Molecular Genetics and Microbiology · 2024 - Present Molecular Genetics and Microbiology, Basic Science Departments
Professor of Integrative Immunobiology · 2024 - Present Integrative Immunobiology, Basic Science Departments
Professor in Cell Biology · 2024 - Present Cell Biology, Basic Science Departments
Professor in Pathology · 2026 - Present Pathology, Clinical Science Departments

Recent News Items


Published March 25, 2026
Duke Honors 38 Distinguished Professors in 2026
Published February 3, 2025
Celebrating Duke’s New Full Professors
Published November 9, 2022
Mysterious Outbreak of Bone-Eating TB Resembled an Ancestral Form

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Recent Scholarly Works


Toxoplasma gondii GRA66 prevents premature egress driven by the host phospholipase RARRES3, independently of RNF213.

Journal article bioRxiv · September 13, 2026 UNLABELLED: Toxoplasma gondii replicates inside a host-derived parasitophorous vacuole (PV), and interferon-gamma (IFNγ) induces host restriction factors that target this compartment. Previous CRISPR screens identified the dense granule protein GRA66 and t ... Full text Link to item Cite

RNF213-dependent lytic destruction of Chlamydia-containing vacuoles activates host cell death pathways.

Journal article Proc Natl Acad Sci U S A · September 2026 The cytokine gamma-interferon promotes antimicrobial cell-autonomous immunity by inducing hundreds of interferon-stimulated genes (ISGs). Among these ISGs is the ubiquitin E3 ligase RNF213 which protects host cells from a wide range of intracellular pathog ... Full text Link to item Cite

Intracellular pathogen targeting by IL32 elicits cell-autonomous immunity.

Journal article bioRxiv · July 25, 2026 Interferon-γ safeguards humans against intracellular pathogens, yet how most interferon-stimulated genes protect host cells, and how human-adapted pathogens evade these defenses is unclear 1,2 . Here, we discover a potent immune surveillance and effector c ... Full text Link to item Cite
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Recent Grants


Genetics and Genomics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2026 - 2031

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2026 - 2031

Innate immune defenses against a cytosolic capsule

ResearchCo Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2020 - 2030

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Education


University of Basel (Switzerland) · 2004 Ph.D.