Overview
Bacterial infections remain one of the leading causes of morbidity and mortality worldwide. The Coers lab seeks to understand fundamental aspects of the innate immune response to bacterial pathogens as well as the corresponding immune evasion strategies evolved by human pathogens undermining immunity in order to establish infections. Defining innate immunity and microbial counter-immunity pathways on a molecular level will provide roadmaps for the rational design of novel antimicrobial therapies and improved vaccine strategies against pathogens such as the enteric pathogen Shigella or the sexually transmitted pathogen Chlamydia.
In addition to making major inroads in the fields of innate immunity, inflammation and bacterial pathogenesis, our second, but equally important goal, is to train the next generation of scientists in an environment that prioritizes excellence, research integrity, teamwork and inclusiveness. We strive to create an environment of mutual respect, openness, collegiality, integrity and, last but not least, fun, which promotes and awards curiosity and fosters collaborations. We strongly believe that diversity promotes excellence.
Current Appointments & Affiliations
Recent Publications
Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen Burkholderia thailandensis.
Journal Article bioRxiv · March 28, 2025 Several human pathogens exploit the kinetic forces generated by polymerizing actin to power their intracellular motility. Human cell-autonomous immune responses activated by the cytokine interferon-gamma (IFNγ) interfere with such microbial actin-based mot ... Full text Link to item CiteType I interferon signaling and peroxisomal dysfunction contribute to enhanced inflammatory cytokine production in IRGM1-deficient macrophages.
Journal Article J Biol Chem · November 2024 The human IRGM gene has been linked to inflammatory diseases including sepsis and Crohn's disease. Decreased expression of human IRGM, or the mouse orthologues Irgm1 and Irgm2, leads to increased production of a number of inflammatory chemokines and cytoki ... Full text Link to item CiteThe Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation.
Journal Article bioRxiv · September 5, 2024 A central signal that marshals host defense against many infections is the lymphocyte-derived cytokine interferon-gamma (IFNγ). The IFNγ receptor is expressed on most human cells and its activation leads to the expression of antimicrobial proteins that exe ... Full text Link to item CiteRecent Grants
Interferon-inducible cell-intrinsic host defense against Chlamydia trachomatis
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2028Interferon-inducible cell-autonomous immunity to cytosolic bacterial pathogens
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2028Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027View All Grants