Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Basel 2004
• 

  Duke Appointment History

  • Assistant Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2010 - 2018
• Recognition
• 

  In the News

  • JUN 30, 2016

    BWF Gives 5-Year Award to Jörn Coers

  • SEP 28, 2015

    Molecular ‘Kiss Of Death’ Flags Pathogens For Destruction
• 

  Awards & Honors

  • ICAAC Young Investigator Awards. American Society for Microbiology. 2011
• Research
• 

  Selected Grants

  • Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
  • Host-mediated lysis of cytoplasmic pathogens awarded by Burroughs Wellcome Fund 2016 - 2021
  • Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • Basic Immunology Training Program awarded by National Institutes of Health 2014 - 2019
  • Interferon-driven ubiquitin response targets Chlamydia inclusions in human cells awarded by National Institutes of Health 2017 - 2019
  • IRGM-driven host responses to Chlamydia trachomatis infections awarded by National Institutes of Health 2013 - 2019
  • Innate immune recognition of bacterial secretion systems by GBPs awarded by National Institutes of Health 2016 - 2018
  • Targeting of Interferon-induced host proteins to Legionella-containing vacuoles awarded by National Institutes of Health 2012 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Conference Papers

    • Feeley, EM, Pilla-Moffett, D, Piro, A, Finethy, R, and Coers, J. "GALECTIN 3 FACILITATES RECRUITMENT OF THE GUANYLATE BINDING PROTEINS TO THE PATHOGEN CONTAINING VACUOLE." November 2016.  Link to Item
    • Finethy, R, Piro, A, Haldar, A, Taylor, G, and Coers, J. "IMMUNITY RELATED GTPASES CONTROL CASPASE-11 ACTIVITY TO PROTECT AGAINST SEPTIC SHOCK." November 2016.  Link to Item
    • Coers, J. "Ubiquitination of pathogen-containing vacuoles triggers host defense by IFN-inducible GBPs." November 2015.  Full Text  Link to Item
    • Haldar, AK, Foltz, C, Finethy, R, Piro, AS, Feeley, EM, Pilla-Moffett, DM, Komatsu, M, Frickel, E-M, and Coers, J. "Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins." October 2015.  Full Text
    • Coers, J, Berstein-Hanley, I, Balsara, ZR, Starnbach, MN, and Dietrich, WF. "Intracellular host defense to Chlamydia trachomatis infections is mediated by IFNgamma-inducible p47 (IRG) GTPases in mice." April 1, 2006.  Link to Item
    • Coers, J, Ranft, C, Ziegler, S, and Skoda, R. "Inhibitory effect of a truncated form of c-MPL on TPO-dependent cell survival and proliferation." July 2003.  Link to Item

  • Journal Articles

    • Piro, AS, Hernandez, D, Luoma, S, Feeley, EM, Finethy, R, Yirga, A, Frickel, EM, Lesser, CF, and Coers, J. "Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility." mBio 8, no. 6 (December 12, 2017).  Full Text
    • Coers, J. "Sweet host revenge: Galectins and GBPs join forces at broken membranes." Cellular microbiology 19, no. 12 (December 2017). (Review)  Full Text
    • Finethy, R, Luoma, S, Orench-Rivera, N, Feeley, EM, Haldar, AK, Yamamoto, M, Kanneganti, T-D, Kuehn, MJ, and Coers, J. "Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins." mBio 8, no. 5 (October 3, 2017).  Full Text  Open Access Copy
    • Zwack, EE, Feeley, EM, Burton, AR, Hu, B, Yamamoto, M, Kanneganti, T-D, Bliska, JB, Coers, J, and Brodsky, IE. "Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components." Infection and immunity 85, no. 10 (October 2017).  Full Text
    • Biering, SB, Choi, J, Halstrom, RA, Brown, HM, Beatty, WL, Lee, S, McCune, BT, Dominici, E, Williams, LE, Orchard, RC, Wilen, CB, Yamamoto, M, Coers, J, Taylor, GA, and Hwang, S. "Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases." Cell host & microbe 22, no. 1 (July 2017): 74-85.e7.  Full Text
    • Schmidt, EA, Fee, BE, Henry, SC, Nichols, AG, Shinohara, ML, Rathmell, JC, MacIver, NJ, Coers, J, Ilkayeva, OR, Koves, TR, and Taylor, GA. "Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages." The Journal of biological chemistry 292, no. 11 (March 2017): 4651-4662.  Full Text
    • Feeley, EM, Pilla-Moffett, DM, Zwack, EE, Piro, AS, Finethy, R, Kolb, JP, Martinez, J, Brodsky, IE, and Coers, J. "Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems." Proceedings of the National Academy of Sciences of the United States of America 114, no. 9 (February 13, 2017): E1698-E1706.  Full Text
    • Sixt, BS, Bastidas, RJ, Finethy, R, Baxter, RM, Carpenter, VK, Kroemer, G, Coers, J, and Valdivia, RH. "The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs." Cell host & microbe 21, no. 1 (January 2017): 113-121.  Full Text
    • Haldar, AK, Piro, AS, Finethy, R, Espenschied, ST, Brown, HE, Giebel, AM, Frickel, E-M, Nelson, DE, and Coers, J. "Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells." mBio 7, no. 6 (December 13, 2016).  Full Text
    • Pensinger, DA, Boldon, KM, Chen, GY, Vincent, WJB, Sherman, K, Xiong, M, Schaenzer, AJ, Forster, ER, Coers, J, Striker, R, and Sauer, J-D. "The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence." PLoS pathogens 12, no. 11 (November 2, 2016): e1006001-.  Full Text
    • Finethy, R, and Coers, J. "Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis." FEMS microbiology reviews 40, no. 6 (November 2016): 875-893. (Review)  Full Text
    • Johnston, AC, Piro, A, Clough, B, Siew, M, Virreira Winter, S, Coers, J, and Frickel, E-M. "Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii." Cellular microbiology 18, no. 8 (August 2016): 1056-1064.  Full Text
    • Pilla-Moffett, D, Barber, MF, Taylor, GA, and Coers, J. "Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease." Journal of molecular biology 428, no. 17 (August 2016): 3495-3513. (Review)  Full Text
    • Finethy, R, and Coers, J. "Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis." FEMS microbiology reviews (July 29, 2016). (Review)
    • "Erratum." Autophagy 12, no. 2 (February 2016): 443-443.  Full Text
    • Finethy, R, Jorgensen, I, Haldar, AK, de Zoete, MR, Strowig, T, Flavell, RA, Yamamoto, M, Nagarajan, UM, Miao, EA, and Coers, J. "Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages." Infection and immunity 83, no. 12 (December 2015): 4740-4749.  Full Text
    • Coers, J, and Haldar, AK. "Ubiquitination of pathogen-containing vacuoles promotes host defense to Chlamydia trachomatis and Toxoplasma gondii." Communicative & integrative biology 8, no. 6 (November 2015): e1115163-. (addendum)  Full Text
    • Aachoui, Y, Kajiwara, Y, Leaf, IA, Mao, D, Ting, JP-Y, Coers, J, Aderem, A, Buxbaum, JD, and Miao, EA. "Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium." Cell host & microbe 18, no. 3 (September 2015): 320-332.  Full Text
    • Pilla, DM, Hagar, JA, Haldar, AK, Mason, AK, Degrandi, D, Pfeffer, K, Ernst, RK, Yamamoto, M, Miao, EA, and Coers, J. "Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS." Proceedings of the National Academy of Sciences of the United States of America 111, no. 16 (April 8, 2014): 6046-6051.  Full Text
    • Haldar, AK, Piro, AS, Pilla, DM, Yamamoto, M, and Coers, J. "The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance." PloS one 9, no. 1 (January 17, 2014): e86684-.  Full Text
    • Furuse, Y, Finethy, R, Saka, HA, Xet-Mull, AM, Sisk, DM, Smith, KLJ, Lee, S, Coers, J, Valdivia, RH, Tobin, DM, and Cullen, BR. "Search for microRNAs expressed by intracellular bacterial pathogens in infected mammalian cells." PloS one 9, no. 9 (January 2014): e106434-.  Full Text  Open Access Copy
    • Coers, J. "Self and non-self discrimination of intracellular membranes by the innate immune system." PLoS Pathog 9, no. 9 (September 2013): e1003538-.  Full Text  Link to Item
    • Traver, MK, Henry, SC, Cantillana, V, Oliver, T, Hunn, JP, Howard, JC, Beer, S, Pfeffer, K, Coers, J, and Taylor, GA. "Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy." J Biol Chem 288, no. 16 (April 19, 2013): 11504-.  Full Text  Link to Item
    • Haldar, AK, Saka, HA, Piro, AS, Dunn, JD, Henry, SC, Taylor, GA, Frickel, EM, Valdivia, RH, and Coers, J. "IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins." PLoS Pathog 9, no. 6 (2013): e1003414-.  Full Text  Link to Item
    • Traver, MK, Henry, SC, Cantillana, V, Oliver, T, Hunn, JP, Howard, JC, Beer, S, Pfeffer, K, Coers, J, and Taylor, GA. "Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy." J Biol Chem 286, no. 35 (September 2, 2011): 30471-30480.  Full Text  Link to Item
    • Coers, J, Gondek, DC, Olive, AJ, Rohlfing, A, Taylor, GA, and Starnbach, MN. "Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections." PLoS Pathog 7, no. 6 (June 2011): e1001346-.  Full Text  Link to Item
    • Khaminets, A, Hunn, JP, Könen-Waisman, S, Zhao, YO, Preukschat, D, Coers, J, Boyle, JP, Ong, Y-C, Boothroyd, JC, Reichmann, G, and Howard, JC. "Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole." Cell Microbiol 12, no. 7 (July 2010): 939-961.  Full Text  Link to Item
    • Coers, J, Starnbach, MN, and Howard, JC. "Modeling infectious disease in mice: co-adaptation and the role of host-specific IFNgamma responses." PLoS Pathog 5, no. 5 (May 2009): e1000333-.  Full Text  Link to Item
    • Henry, SC, Daniell, XG, Burroughs, AR, Indaram, M, Howell, DN, Coers, J, Starnbach, MN, Hunn, JP, Howard, JC, Feng, CG, Sher, A, and Taylor, GA. "Balance of Irgm protein activities determines IFN-gamma-induced host defense." J Leukoc Biol 85, no. 5 (May 2009): 877-885.  Full Text  Link to Item
    • Tiedt, R, Coers, J, Ziegler, S, Wiestner, A, Hao-Shen, H, Bornmann, C, Schenkel, J, Karakhanova, S, de Sauvage, FJ, Jackson, CW, and Skoda, RC. "Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes." Blood 113, no. 8 (February 19, 2009): 1768-1777.  Full Text  Link to Item
    • Coers, J, Bernstein-Hanley, I, Grotsky, D, Parvanova, I, Howard, JC, Taylor, GA, Dietrich, WF, and Starnbach, MN. "Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10." J Immunol 180, no. 9 (May 1, 2008): 6237-6245.  Link to Item
    • Coers, J, Vance, RE, Fontana, MF, and Dietrich, WF. "Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways." Cell Microbiol 9, no. 10 (October 2007): 2344-2357.  Full Text  Link to Item
    • Bernstein-Hanley, I, Coers, J, Balsara, ZR, Taylor, GA, Starnbach, MN, and Dietrich, WF. "The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice." Proc Natl Acad Sci U S A 103, no. 38 (September 19, 2006): 14092-14097.  Full Text  Link to Item
    • Bernstein-Hanley, I, Balsara, ZR, Ulmer, W, Coers, J, Starnbach, MN, and Dietrich, WF. "Genetic analysis of susceptibility to Chlamydia trachomatis in mouse." Genes Immun 7, no. 2 (March 2006): 122-129.  Full Text  Link to Item
    • Coers, J, Ranft, C, and Skoda, RC. "A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation." J Biol Chem 279, no. 35 (August 27, 2004): 36397-36404.  Full Text  Link to Item
    • Kralovics, R, Buser, AS, Teo, S-S, Coers, J, Tichelli, A, van der Maas, APC, and Skoda, RC. "Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders." Blood 102, no. 5 (September 1, 2003): 1869-1871.  Full Text  Link to Item
    • Coers, J, Kagan, JC, Matthews, M, Nagai, H, Zuckman, DM, and Roy, CR. "Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth." Mol Microbiol 38, no. 4 (November 2000): 719-736.  Link to Item
    • Roy, CR, and Coers, J. "Exploitation of macrophages as a replication niche by Legionella pneumophila: response." Trends Microbiol 8, no. 2 (February 2000): 49-50.  Link to Item
    • Coers, J, Monahan, C, and Roy, CR. "Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth." Nat Cell Biol 1, no. 7 (November 1999): 451-453.  Full Text  Link to Item

  • Other Articles

    • Klionsky, DJ, Abdelmohsen, K, Abe, A, Abedin, MJ, Abeliovich, H, Acevedo Arozena, A, Adachi, H, Adams, CM, Adams, PD, Adeli, K, Adhihetty, PJ, Adler, SG, Agam, G, Agarwal, R, Aghi, MK, Agnello, M, Agostinis, P, Aguilar, PV, Aguirre-Ghiso, J, Airoldi, EM, Ait-Si-Ali, S, Akematsu, T, Akporiaye, ET, Al-Rubeai, M, Albaiceta, GM, Albanese, C, Albani, D, Albert, ML, Aldudo, J, Algül, H, Alirezaei, M, Alloza, I, Almasan, A, Almonte-Beceril, M, Alnemri, ES, Alonso, C, Altan-Bonnet, N, and Altieri, DC et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)." Autophagy 12, no. 1 (January 2016): 1-222.  Full Text
• Teaching & Mentoring
• 

  Recent Courses

  • MGM 293: Research Independent Study I 2018
  • MGM 593: Research Independent Study 2018
  • MGM 703: Advanced Topics in Infection Biology 2016

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