Overview
Infectious diseases remain one of the leading causes of morbidity and mortality in the United States and worldwide. The Coers lab seeks to understand fundamental aspects of the immune response to microbes as well as the corresponding immune evasion strategies evolved by human pathogens to undermine immunity and establish infections. Defining human immunity and microbial counter-immunity pathways on a molecular level will provide roadmaps for the rational design of novel antimicrobial therapies and improved vaccine strategies against human pathogens such as the enteric bacterial pathogen Shigella or the sexually transmitted bacterial pathogen Chlamydia.
In addition to making major inroads in the fields of immunity, inflammation and microbial pathogenesis, our second, but equally important goal, is to train the next generation of scientists in an environment that prioritizes excellence, research integrity, learning opportunities, and teamwork. We strive to create an environment of mutual respect, openness, collegiality, integrity and, last but not least, fun, which promotes and awards curiosity and fosters collaborations.
Current Duke Appointments & Affiliations
Recent Scholarly Works
Toxoplasma gondii GRA66 prevents premature egress driven by the host phospholipase RARRES3, independently of RNF213.
Journal article bioRxiv · September 13, 2026 UNLABELLED: Toxoplasma gondii replicates inside a host-derived parasitophorous vacuole (PV), and interferon-gamma (IFNγ) induces host restriction factors that target this compartment. Previous CRISPR screens identified the dense granule protein GRA66 and t ... Full text Link to item CiteRNF213-dependent lytic destruction of Chlamydia-containing vacuoles activates host cell death pathways.
Journal article Proc Natl Acad Sci U S A · September 2026 The cytokine gamma-interferon promotes antimicrobial cell-autonomous immunity by inducing hundreds of interferon-stimulated genes (ISGs). Among these ISGs is the ubiquitin E3 ligase RNF213 which protects host cells from a wide range of intracellular pathog ... Full text Link to item CiteIntracellular pathogen targeting by IL32 elicits cell-autonomous immunity.
Journal article bioRxiv · July 25, 2026 Interferon-γ safeguards humans against intracellular pathogens, yet how most interferon-stimulated genes protect host cells, and how human-adapted pathogens evade these defenses is unclear 1,2 . Here, we discover a potent immune surveillance and effector c ... Full text Link to item CiteRecent Grants
Genetics and Genomics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2026 - 2031Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2026 - 2031Innate immune defenses against a cytosolic capsule
ResearchCo Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2020 - 2030View All Grants