Joseph Yuan-Chieh Lo
Professor of Radiology
My lab focuses on the diagnosis and treatment of breast cancer using advanced imaging techniques. There are 2 main projects: radiomics and breast modeling.
First, radiomics is an interdisciplinary field combining computer vision, machine learning, and informatics. We develop computer vision algorithms to detect suspicious mammographic lesions. We also created predictive models that use machine learning and statistical analysis in order to classify mammograms. In ongoing studies funded by NIH, DOD, and several other organizations, we are addressing the clinically significant challenge of over-diagnosis of DCIS. By exploring the relationship between imaging findings and genomic markers, we seek to predict which cases of DCIS are likely to be indolent vs. aggressive, thus providing women with more personalized risk assessment to inform their treatment decisions.
Second, we are designing new virtual breast models that are based on actual patient data. These models go far beyond conventional phantoms in portraying realistic breast anatomy. Furthermore, we can transform these virtual models into physical form using the latest 3D printing technology. Such physical phantoms can be scanned on actual mammography and digital breast tomosynthesis systems, allowing us to assess image quality in new ways that are not only quantitative but also clinically relevant. We continue to refine the realism of these physical phantoms, and seek to develop new procedures for quality control, system evaluation, and the long term goal of virtual clinical trials.
First, radiomics is an interdisciplinary field combining computer vision, machine learning, and informatics. We develop computer vision algorithms to detect suspicious mammographic lesions. We also created predictive models that use machine learning and statistical analysis in order to classify mammograms. In ongoing studies funded by NIH, DOD, and several other organizations, we are addressing the clinically significant challenge of over-diagnosis of DCIS. By exploring the relationship between imaging findings and genomic markers, we seek to predict which cases of DCIS are likely to be indolent vs. aggressive, thus providing women with more personalized risk assessment to inform their treatment decisions.
Second, we are designing new virtual breast models that are based on actual patient data. These models go far beyond conventional phantoms in portraying realistic breast anatomy. Furthermore, we can transform these virtual models into physical form using the latest 3D printing technology. Such physical phantoms can be scanned on actual mammography and digital breast tomosynthesis systems, allowing us to assess image quality in new ways that are not only quantitative but also clinically relevant. We continue to refine the realism of these physical phantoms, and seek to develop new procedures for quality control, system evaluation, and the long term goal of virtual clinical trials.
Current Appointments & Affiliations
- Professor of Radiology, Radiology, Clinical Science Departments 2014
- Professor in the Department of Electrical and Computer Engineering, Electrical and Computer Engineering, Pratt School of Engineering 2014
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1993
Contact Information
- 2424 Erwin Road, Suite 302, Ravin Advanced Imaging Labs, Durham, NC 27705
- Ravin Advanced Imaging Labs, 2424 Erwin Road, Suite 302, Durham, NC 27705
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joseph.lo@duke.edu
(919) 684-7763
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Google Scholar
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Home Page
- Background
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Education, Training, & Certifications
- Research Associate, Radiology, Duke University 1993 - 1995
- Research Assistant, Biomedical Engineering & Radiology, Duke University 1988 - 1993
- Ph.D., Duke University 1993
- Teaching Assistant, Biomedical Engineering, Duke University 1988 - 1990
- B.S.E.E., Duke University 1988
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Duke Appointment History
- Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2014 - 2017
- Professor in the Department of Electrical and Computer Engineering, Electrical and Computer Engineering, Pratt School of Engineering 2014 - 2016
- Associate Research Professor in the Department of Electrical and Computer Engineering, Electrical and Computer Engineering, Pratt School of Engineering 2011 - 2015
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2005 - 2014
- Associate Professor in the Department of Radiology, Radiology, Clinical Science Departments 2009 - 2014
- Assistant Professor in Radiology, Radiology, Clinical Science Departments 2006 - 2009
- Assistant Research Professor in Radiology, Radiology, Clinical Science Departments 1995 - 2006
- Assistant Research Professor in Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 1997 - 2005
- Expertise
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Subject Headings
- Breast Diseases
- Breast Neoplasms
- Clinical Trials as Topic
- Computer Simulation
- Contrast Media
- Decision Making, Computer-Assisted
- Decision Support Systems, Clinical
- Decision Support Techniques
- Education
- Evaluation Studies as Topic
- Image Processing, Computer-Assisted
- Imaging, Three-Dimensional
- Machine learning
- Mammography
- Models, Psychological
- Models, Structural
- Pattern Recognition, Automated
- ROC Curve
- Radiographic Image Interpretation, Computer-Assisted
- Radiology
- Signal-To-Noise Ratio
- Technology Assessment, Biomedical
- Tomosynthesis
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Global Scholarship
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Expertise
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- Research
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Selected Grants
- Breast Cancer Detection Consortium awarded by National Institutes of Health 2016 - 2021
- Genomic Diversity and the Microenvironment as Drivers of Progression in DCIS awarded by Department of Defense 2014 - 2020
- Machine learning and collaborative filtering tools for personalized education in digital breast tomosynthesis awarded by National Institutes of Health 2016 - 2020
- 3D Printing of Anatomically Realistic Phantoms for Optimization of Imaging Algorithms awarded by National Institutes of Health 2018 - 2020
- Training in Medical Imaging awarded by National Institutes of Health 2003 - 2019
- Molecular and Radiologic Predictors of Invasion in a DCIS Active Surveillance Cohort awarded by Breast Cancer Research Foundation 2016 - 2018
- (PQC3) Genomic Diversity and Microenvironment as Drivers of Metastasis in DCIS awarded by National Institutes of Health 2014 - 2018
- Improved education in digital breast tomosynthesis using machine learning and computer vision tools awarded by Radiological Society of North America 2014 - 2016
- (PQA5) 'Dose and Mechanisms of Exercise in Breast Cancer Prevention' awarded by National Institutes of Health 2013 - 2014
- 3D Digital Breast Phantoms For Multimodality Research awarded by National Institutes of Health 2010 - 2014
- Cross-disciplinary Training in Medical Physics awarded by National Institutes of Health 2007 - 2013
- Information-Theoretic Based CAD in Mammography awarded by National Institutes of Health 2003 - 2011
- Tomosynthesis for Improved Breast Cancer Detection awarded by National Institutes of Health 2006 - 2011
- Accurate Models for Predicting Radiation-Induced Injury awarded by National Institutes of Health 2006 - 2011
- Reducing Benign Breast Biopsies with Computer Modeling awarded by National Institutes of Health 2003 - 2008
- Predicting Breast Cancer With Ultrasound and Mammography awarded by National Institutes of Health 2002 - 2005
- Improved Diagnosis of Breast Microcalcification Clusters awarded by National Institutes of Health 2001 - 2004
- Computer-Aided Diagnosis Of Breast Cancer Invasion awarded by National Institutes of Health 1998 - 2003
- Computer Aid for the Decision to Biopsy Breast Lesions awarded by US Army Medical Research 1999 - 2002
- Computer Aid for the Decision to Biopsy Breast Lesions awarded by National Institutes of Health 1999 - 2001
- Publications & Artistic Works
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Selected Publications
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Book Sections
- Robinson, MD, Farsiu, S, Lo, JY, and Toth, CA. "Efficient restoration and enhancement of super-resolved X-ray images." 629-632. 2008. Full Text
- Jesneck, JL, Mukherjee, S, Nolte, LW, Lokshin, AE, Marks, JR, and Lo, J. "Decision fusion of circulating markers for breast cancer detection in premenopausal women." 1434-1438. 2007. Full Text
- Land, WH, McKee, DW, Anderson, FR, Masters, T, Lo, JY, Embrechts, M, and Heine, J. "Using computational intelligence for computer-aided diagnosis of screen-film mammograms." In Recent Advances in Breast Imaging, Mammography, and Computer-Aided Diagnosis of Breast Cancer, 315-375. April 10, 2006. Full Text
- Lo, JY, Bilska-Wolak, AO, Baker, JA, Tourassi, GD, Floyd, CE, and Markey, MK. "Computer-aided diagnosis in breast imaging: Where do we go after detection?." In Recent Advances in Breast Imaging, Mammography, and Computer-Aided Diagnosis of Breast Cancer, 871-900. April 10, 2006. Full Text
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Conference Papers
- Lo, JY, Grimm, LJ, Mazurowski, MA, Baker, JA, Marks, JR, King, LM, Maley, CC, Hwang, E-SS, and Shi, B. "Prediction of occult invasive disease in ductal carcinoma in situ using deep learning features." February 2018. Link to Item
- Hou, R, Shi, B, Grimm, LJ, Mazurowski, MA, Marks, JR, King, LM, Maley, CC, Hwang, ES, and Lo, JY. "Improving classification with forced labeling of other related classes: application to prediction of upstaged ductal carcinoma in situ using mammographic features." SPIE, 2018.
- Shi, B, Hou, R, Mazurowski, MA, Grimm, LJ, Ren, Y, Marks, JR, King, LM, Maley, CC, Hwang, ES, and Lo, JY. "Learning better deep features for the prediction of occult invasive disease in ductal carcinoma in situ through transfer learning." SPIE, 2018.
- Chen, X, Gong, X, Graff, CG, Santana, M, Sturgeon, GM, Sauer, TJ, Zeng, R, Glick, SJ, and Lo, JY. "High-resolution, anthropomorphic, computational breast phantom: Fusion of rule-based structures with patient-based anatomy." January 1, 2017. Full Text
- Ikejimba, LC, Graff, CG, Rosenthal, S, Badal, A, Ghammraoui, B, Lo, JY, and Glick, SJ. "A physical breast phantom for 2D and 3D x-ray imaging made through inkjet printing." January 1, 2017. Full Text
- Reinhold, J, Wen, G, Lo, JY, and Markey, MK. "Lesion detectability in stereoscopically viewed digital breast tomosynthesis projection images: A model observer study with anthropomorphic computational breast phantoms." January 1, 2017. Full Text
- Sauer, TJ, Graff, CG, Zeng, R, Santana, M, Sturgeon, GM, Bosmans, H, Glick, SJ, Chen, XC, Segars, WP, and Lo, JY. "Detectability of artificial lesions in anthropomorphic virtual breast phantoms of variable glandular fraction." January 1, 2017. Full Text
- Shi, B, Grimm, LJ, Mazurowski, MA, Marks, JR, King, LM, Maley, CC, Hwang, ES, and Lo, JY. "Prediction of occult invasive disease in ductal carcinoma in situ using computer-extracted mammographic features." January 1, 2017. Full Text
- Shi, B, Grimm, LJ, Mazurowski, MA, Marks, JR, King, LM, Maley, CC, Hwang, ES, and Lo, JY. "Can upstaging of ductal carcinoma in situ be predicted at biopsy by histologic and mammographic features?." January 1, 2017. Full Text
- Zhao, A, Santana, M, Samei, E, and Lo, J. "Comparison of effects of dose on image quality in digital breast tomosynthesis across multiple vendors." January 1, 2017. Full Text
- Zhao, C, Solomon, J, Sturgeon, GM, Gehm, ME, Catenacci, M, Wiley, BJ, Samei, E, and Lo, JY. "Third generation anthropomorphic physical phantom for mammography and DBT: Incorporating voxelized 3D printing and uniform chest wall QC region." January 1, 2017. Full Text
- Ikejimba, L, Glick, SJ, Samei, E, and Lo, JY. "Comparison of model and human observer performance in FFDM, DBT, and synthetic mammography." January 1, 2016. Full Text
- Makeev, A, Ikejimba, L, Lo, JY, and Glick, SJ. "Investigation of optimal parameters for penalized maximum-likelihood reconstruction applied to iodinated contrast-enhanced breast CT." January 1, 2016. Full Text
- Sikaria, D, Musinsky, S, Sturgeon, GM, Solomon, J, Diao, A, Gehm, ME, Samei, E, Glick, SJ, and Lo, JY. "Second generation anthropomorphic physical phantom for mammography and DBT: Incorporating voxelized 3D printing and inkjet printing of iodinated lesion inserts." January 1, 2016. Full Text
- Solomon, J, Ba, A, Diao, A, Lo, J, Bier, E, Bochud, F, Gehm, M, and Samei, E. "Design, fabrication, and implementation of voxel-based 3D printed textured phantoms for task-based image quality assessment in CT." January 1, 2016. Full Text
- Sturgeon, GM, Tward, DJ, Ketcha, M, Ratnanather, JT, Miller, MI, Park, S, Segars, WP, and Lo, JY. "Eigenbreasts for statistical breast phantoms." January 1, 2016. Full Text
- Wang, M, Zhang, J, Grimm, LJ, Ghate, SV, Walsh, R, Johnson, KS, Lo, JY, and Mazurowski, MA. "Identification of error making patterns in lesion detection on digital breast tomosynthesis using computer-extracted image features." January 1, 2016. Full Text
- Grimm, LJ, Zhang, J, Johnson, KS, Lo, JY, and Mazurowski, MA. "Incorporating breast tomosynthesis into radiology residency: Does trainee experience in breast imaging translate into improved performance with this new modality?." January 1, 2015. Full Text
- Ikejimba, L, Chen, Y, Oberhofer, N, Kiarashi, N, Lo, JY, and Samei, E. "A quantitative metrology for performance characterization of breast tomosynthesis systems based on an anthropomorphic phantom." January 1, 2015. Full Text
- Kiarashi, N, Nolte, LW, Lo, JY, Segars, WP, Ghate, SV, and Samei, E. "The impact of breast structure on lesion detection in breast tomosynthesis." January 1, 2015. Full Text
- Mahadevan, R, Ikejimba, LC, Lin, Y, Samei, E, and Lo, JY. "A task-based comparison of two reconstruction algorithms for digital breast tomosynthesis." January 1, 2014. Full Text
- Mazurowski, MA, Zhang, J, Lo, JY, Kuzmiak, CM, Ghate, SV, and Yoon, S. "Modeling resident error-making patterns in detection of mammographic masses using computer-extracted image features: Preliminary experiments." January 1, 2014. Full Text
- Nolte, A, Kiarashi, N, Samei, E, Segars, WP, and Lo, JY. "A second generation of physical anthropomorphic 3D breast phantoms based on human subject data." January 1, 2014. Full Text
- Segars, WP, Veress, AI, Wells, JR, Sturgeon, GM, Kiarashi, N, Lo, JY, Samei, E, and Dobbins, JT. "Population of 100 realistic, patient-based computerized breast phantoms for multi-modality imaging research." January 1, 2014. Full Text
- Kiarashi, N, Sturgeon, GM, Nolte, LW, Lo, JY, III, JTD, Segars, WP, and Samei, E. "Development of matched virtual and physical breast phantoms based on patient data." 2013. Full Text
- Chanyavanich, V, Lo, J, and Das, S. "SU-E-T-572: A Plan Quality Metric for Evaluating Knowledge-Based Treatment Plans." United States. June 2012. Full Text Link to Item
- Dick, D, Das, S, and Lo, J. "WE-G-BRCD-06: Knowledge-Based Intensity Modulated Radiotherapy (IMRT) Treatment Planning for Prostate Cancer." United States. June 2012. Full Text Link to Item
- Ikejimba, L, Kiarashi, N, Lin, Y, Chen, B, Ghate, SV, Zerhouni, M, Samei, E, and Lo, JY. "Task-based strategy for optimized contrast enhanced breast imaging: Analysis of six imaging techniques for mammography and tomosynthesis." 2012. Full Text
- Kiarashi, N, Lin, Y, Segars, WP, Ghate, SV, Ikejimba, L, Chen, B, Lo, JY, Iii, JTD, Nolte, LW, and Samei, E. "Development of a dynamic 4D anthropomorphic breast phantom for contrast-based breast imaging." 2012. Full Text
- Lin, Y, Ghate, S, Lo, J, and Samei, E. "3D biopsy for tomosynthesis: Simulation of prior information based reconstruction for dose and artifact reduction." 2012. Full Text
- Chanyavanich, V, Das, S, and Lo, J. "SU-E-T-851: An Inter-Institutional Comparison of Knowledge-Based IMRT Treatment Planning for Prostate Cancer." June 2011. Full Text
- Shafer, CM, Seewaldt, VL, and Lo, JY. "Segmentation of adipose and glandular tissue for breast tomosynthesis imaging using a 3D hidden-Markov model trained on breast MRIs." 2011. Full Text
- Chanyavanich, V, Freeman, M, Das, S, and Lo, J. "SU-GG-T-134: Knowledge-Based IMRT Treatment Planning for Prostate Cancer." June 2010. Full Text
- Freeman, MS, Chanyavanich, V, Das, SK, and Lo, JY. "SU-GG-T-131: A Linear Metric of Knowledge-Based IMRT Treatment Plan Quality for the Prostate." June 2010. Full Text
- Lo, J, Baydush, A, Karim, E, and Mendonca, S. "WE-A-201B-04: Reducing Dose in Breast Tomosynthesis Using Bayesian Image Estimation." June 2010. Full Text
- Mehtaji, D, Shafer, C, Chen, B, and Lo, J. "SU-GG-I-154: Evaluation of Quantitative Potential of Breast Tomosynthesis Using a Voxelized Anthropomorphic Breast Phantom." June 2010. Full Text
- Mazurowski, MA, Lo, JY, and Tourassi, GD. "User modeling for improved computer-aided training in radiology: Initial experience." 2010. Full Text
- Shafer, C, Lo, J, and Samei, E. "MO-FF-A4-01: Evaluation of Background Trend Correction Technique in Breast Tomosynthesis Quantitation." June 2009. Full Text
- Chawla, AS, Samei, E, and Lo, JY. "Optimized lesion detection in breast tomosynthesis." 2009. Full Text
- Li, CM, Segars, WP, Lo, JY, Veress, AI, Boone, JM, and III, JTD. "Computerized 3D breast phantom with enhanced High-Resolution detail." 2009. Full Text
- Lo, J. "TU-D-342-02: What Every Medical Physicist Should Know About Breast Tomosynthesis." June 2008. Full Text
- Chawla, AS, Samei, E, Lo, JY, and Mertelmeier, T. "Multi-projection correlation imaging as a new diagnostic tool for improved breast cancer detection." 2008. Full Text
- Chawla, AS, Samei, E, Saunders, RS, Lo, JY, and Singh, S. "Optimized acquisition scheme for multi-projection correlation imaging of breast cancer." 2008. Full Text
- Li, CM, Segars, WP, Lo, JY, Veress, AI, Boone, JM, and III, JTD. "Three-dimensional computer generated breast phantom based on empirical data." 2008. Full Text
- Robinson, MD, Farsiu, S, Lo, JY, Toth, CA, and IEEE, . "Efficient Restoration and Enhancement of Super-resolved X-ray Images." 2008. Link to Item
- Shafer, CM, Samei, E, Mertelmeier, T, Saunders, RS, Zerhouni, M, and Lo, JY. "Assessment of low energies and slice depth in the quantification of breast tomosynthesis." 2008. Full Text
- Shafer, CM, Samei, E, Saunders, RS, Zerhouni, M, and Lo, JY. "Toward quantification of breast tomosynthesis imaging." 2008. Full Text
- Singh, S, Tourassi, GD, Chawla, AS, Saunders, RS, Samei, E, and Lo, JY. "Computer aided detection of breast masses in tomosynthesis reconstructed volumes using information-theoretic similarity measures." 2008. Full Text
- Singh, S, Tourassi, GD, and Lo, JY. "Effect of similarity metrics and ROI sizes in featureless computer aided detection of breast masses in tomosynthesis." 2008. Full Text
- Tourassi, GD, Sharma, AC, Singh, S, Saunders, RS, Lo, JY, Samei, E, and Harrawood, BP. "Knowledge transfer across breast cancer screening modalities: A pilot study using an information-theoretic CADe system for mass detection." 2008. Full Text
- Xia, JQ, and Lo, JY. "Mass detectability in dedicated breast CT: A simulation study with the application of volume noise removal." 2008. Full Text
- Lo, JY, Singh, S, III, DJT, and Samei, E. "New developments in digital breast tomosynthesis." June 2007. Full Text Link to Item
- Williams, M, Raghunathan, P, Seibert, JA, Kwan, A, Lo, J, Samei, E, Ranger, N, Fajardo, L, McGruder, A, Maxwell, S, Maidment, A, Yaffe, M, Bloomquist, A, and Mawdsley, G. "Optimizing mammography image quality and dose: X-ray spectrum and exposure parameter selection." June 2007. Full Text Link to Item
- Chen, Y, Lo, JY, Ranger, NT, Samei, E, and III, JTD. "Methodology of NEQ (f) analysis for optimization and comparison of digital breast tomosynthesis acquisition techniques and reconstruction algorithms." 2007. Full Text
- Jerebko, A, Quan, Y, Merlet, N, Ratner, E, Singh, S, Lo, JY, and Krishnan, A. "Feasibility study of breast tomosynthesis CAD system." 2007. Full Text
- Johnson, JP, Lo, J, Mertelmeier, T, Nafziger, JS, Timberg, P, and Samei, E. "Visual image quality metrics for optimization of breast tomosynthesis acquisition technique." 2007. Full Text
- Jr, RSS, Samei, E, Majdi-Nasab, N, and Lo, JY. "Initial human subject results for breast Bi-plane correlation imaging technique." 2007. Full Text
- Xia, JQ, Tourassi, GD, Lo, JY, and Jr, CEF. "On the development of a Gaussian noise model for scatter compensation." 2007. Full Text
- Chen, Y, Lo, J, Baker, J, and Dobbins, J. "SU-FF-I-21: Two-Dimensional Shift-And-Add (SAA) Algorithm for Digital Breast Tomosynthesis Reconstruction." June 2006. Full Text
- Hong, AS, Baker, JA, Lo, JY, Nicholas, JL, and Soo, MS. "Computer-aided classification of breast masses using mammogram, ultrasound, and clinical inputs." 2004. Link to Item
- Baydush, AH, Catarious, DM, Lo, JY, Abbey, CK, and Floyd, CE. "Computer-aided detection of lung nodules in chest radiographs using sub-region Hotelling observers." November 2001. Link to Item
- Land, WH, Masters, T, Lo, JY, McKee, DW, and Anderson, FR. "New results in breast cancer classification obtained from an evolutionary computation/adaptive boosting hybrid using mammogram and history data." January 1, 2001. Full Text
- LO, JY, BAYDUSH, AH, BAKER, JA, KORNGUTH, PJ, and FLOYD, CE. "COMPUTER-AIDED DIAGNOSIS OF BREAST MASS MALIGNANCY WITH AUTOMATED FEATURE-EXTRACTION AND ARTIFICIAL NEURAL NETWORKS." November 1995. Link to Item
- FLOYD, CE, YUN, AJ, LO, JY, TOURASSI, G, SULLIVAN, DC, KORNGUTH, PJ, and SOC, INTNN. "PREDICTION OF BREAST-CANCER MALIGNANCY FOR DIFFICULT CASES USING AN ARTIFICIAL NEURAL-NETWORK." 1994. Link to Item
- FLOYD, CE, BOWSHER, JE, MUNLEY, MT, TOURASSI, GD, GARG, S, BAYDUSH, AH, LO, JY, COLEMAN, RE, and IEEE, . "ARTIFICIAL NEURAL NETWORKS FOR SPECT IMAGE-RECONSTRUCTION WITH OPTIMIZED WEIGHTED BACKPROJECTION." 1991. Full Text Link to Item
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Journal Articles
- Shi, B, Grimm, LJ, Mazurowski, MA, Baker, JA, Marks, JR, King, LM, Maley, CC, Hwang, ES, and Lo, JY. "Prediction of Occult Invasive Disease in Ductal Carcinoma in Situ Using Deep Learning Features." Journal of the American College of Radiology : JACR 15, no. 3 Pt B (March 2018): 527-534. Full Text
- Wen, G, Chang, H-C, Reinhold, J, Lo, JY, and Markey, MK. "Virtual assessment of stereoscopic viewing of digital breast tomosynthesis projection images." Journal of medical imaging (Bellingham, Wash.) 5, no. 1 (January 17, 2018): 015501-. Full Text
- Sturgeon, GM, Park, S, Segars, WP, and Lo, JY. "Synthetic breast phantoms from patient based eigenbreasts." Medical physics 44, no. 12 (December 2017): 6270-6279. Full Text
- Shi, B, Grimm, LJ, Mazurowski, MA, Baker, JA, Marks, JR, King, LM, Maley, CC, Hwang, ES, and Lo, JY. "Can Occult Invasive Disease in Ductal Carcinoma In Situ Be Predicted Using Computer-extracted Mammographic Features?." Academic radiology 24, no. 9 (September 2017): 1139-1147. Full Text
- Ikejimba, LC, Graff, CG, Rosenthal, S, Badal, A, Ghammraoui, B, Lo, JY, and Glick, SJ. "A novel physical anthropomorphic breast phantom for 2D and 3D x-ray imaging." Medical physics 44, no. 2 (February 2017): 407-416. Full Text
- Ikejimba, LC, Glick, SJ, Choudhury, KR, Samei, E, and Lo, JY. "Assessing task performance in FFDM, DBT, and synthetic mammography using uniform and anthropomorphic physical phantoms." Medical physics 43, no. 10 (October 2016): 5593-. Full Text
- Wang, M, Zhang, J, Grimm, LJ, Ghate, SV, Walsh, R, Johnson, KS, Lo, JY, and Mazurowski, MA. "Predicting false negative errors in digital breast tomosynthesis among radiology trainees using a computer vision-based approach." Expert Systems with Applications 56 (September 2016): 1-8. Full Text
- Kiarashi, N, Nolte, LW, Lo, JY, Segars, WP, Ghate, SV, Solomon, JB, and Samei, E. "Impact of breast structure on lesion detection in breast tomosynthesis, a simulation study." Journal of Medical Imaging 3, no. 3 (July 2016): 035504-. Full Text
- Sturgeon, GM, Kiarashi, N, Lo, JY, Samei, E, and Segars, WP. "Finite-element modeling of compression and gravity on a population of breast phantoms for multimodality imaging simulation." Medical physics 43, no. 5 (May 2016): 2207-. Full Text
- Ikejimba, L, Lo, JY, Chen, Y, Oberhofer, N, Kiarashi, N, and Samei, E. "A quantitative metrology for performance characterization of five breast tomosynthesis systems based on an anthropomorphic phantom." Medical physics 43, no. 4 (April 2016): 1627-. Full Text
- Grimm, LJ, Zhang, J, Lo, JY, Johnson, KS, Ghate, SV, Walsh, R, and Mazurowski, MA. "Radiology Trainee Performance in Digital Breast Tomosynthesis: Relationship Between Difficulty and Error-Making Patterns." Journal of the American College of Radiology : JACR 13, no. 2 (February 2016): 198-202. Full Text
- Erickson, DW, Wells, JR, Sturgeon, GM, Samei, E, Dobbins, JT, Segars, WP, and Lo, JY. "Population of 224 realistic human subject-based computational breast phantoms." Medical physics 43, no. 1 (January 2016): 23-. Full Text
- Schmidt, M, Lo, JY, Grzetic, S, Lutzky, C, Brizel, DM, and Das, SK. "Semiautomated head-and-neck IMRT planning using dose warping and scaling to robustly adapt plans in a knowledge database containing potentially suboptimal plans." Medical physics 42, no. 8 (August 2015): 4428-4434. Full Text
- Kiarashi, N, Nolte, AC, Sturgeon, GM, Segars, WP, Ghate, SV, Nolte, LW, Samei, E, and Lo, JY. "Development of realistic physical breast phantoms matched to virtual breast phantoms based on human subject data." Medical physics 42, no. 7 (July 2015): 4116-4126. Full Text
- Zhang, J, Grimm, LJ, Lo, JY, Johnson, KS, Ghate, SV, Walsh, R, and Mazurowski, MA. "Does Breast Imaging Experience During Residency Translate Into Improved Initial Performance in Digital Breast Tomosynthesis?." Journal of the American College of Radiology : JACR 12, no. 7 (July 2015): 728-732. Full Text
- Sechopoulos, I, Sabol, JM, Berglund, J, Bolch, WE, Brateman, L, Christodoulou, E, Flynn, M, Geiser, W, Goodsitt, M, Jones, AK, Lo, JY, Maidment, ADA, Nishino, K, Nosratieh, A, Ren, B, Segars, WP, and Von Tiedemann, M. "Radiation dosimetry in digital breast tomosynthesis: report of AAPM Tomosynthesis Subcommittee Task Group 223." Medical physics 41, no. 9 (September 2014): 091501-. Full Text
- Zhang, J, Lo, JY, Kuzmiak, CM, Ghate, SV, Yoon, SC, and Mazurowski, MA. "Using computer-extracted image features for modeling of error-making patterns in detection of mammographic masses among radiology residents." Medical physics 41, no. 9 (September 2014): 091907-. Full Text
- Kiarashi, N, Lo, JY, Lin, Y, Ikejimba, LC, Ghate, SV, Nolte, LW, Dobbins, JT, Segars, WP, and Samei, E. "Development and application of a suite of 4-D virtual breast phantoms for optimization and evaluation of breast imaging systems." IEEE transactions on medical imaging 33, no. 7 (July 2014): 1401-1409. Full Text
- Ikejimba, LC, Kiarashi, N, Ghate, SV, Samei, E, and Lo, JY. "Task-based strategy for optimized contrast enhanced breast imaging: Analysis of six imaging techniques for mammography and tomosynthesis." Medical Physics 41, no. 6Part1 (May 20, 2014): 061908-061908. Full Text
- Good, D, Lo, J, Lee, WR, Wu, QJ, Yin, F-F, and Das, SK. "A knowledge-based approach to improving and homogenizing intensity modulated radiation therapy planning quality among treatment centers: an example application to prostate cancer planning." Int J Radiat Oncol Biol Phys 87, no. 1 (September 1, 2013): 176-181. Full Text Link to Item
- Chung, H, Ikejimba, L, Kiarashi, N, Samei, E, Hoernig, M, and Lo, JY. "Estimating breast density with dual energy mammography: A simple model based on calibration phantoms." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 8668 (2013). Full Text
- Good, D, Lo, J, Lee, WR, Wu, QJ, Yin, F-F, and Das, SK. "A knowledge-based approach to improving and homogenizing intensity modulated radiation therapy planning quality among treatment centers: An example application to prostate cancer planning." International Journal of Radiation Oncology Biology Physics 87, no. 1 (2013): 176-181. Full Text
- Huo, Z, Summers, RM, Paquerault, S, Lo, J, Hoffmeister, J, III, SGA, Freedman, MT, Lin, J, Lo, S-CB, Petrick, N, Sahiner, B, Fryd, D, Yoshida, H, and Chan, H-P. "Quality assurance and training procedures for computer-aided detection and diagnosis systems in clinical use." Medical Physics 40, no. 7 (2013). Full Text
- Kiarashi, N, Ghate, SV, Lo, JY, Nolte, LW, and Samei, E. "Application of a dynamic 4D anthropomorphic breast phantom in contrast-based imaging system optimization: Dual-energy or temporal subtraction?." Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 7361 LNCS (2012): 658-665. Full Text
- Baker, JA, and Lo, JY. "Breast tomosynthesis: state-of-the-art and review of the literature." Acad Radiol 18, no. 10 (October 2011): 1298-1310. (Review) Full Text Link to Item
- Mazurowski, MA, Lo, JY, Harrawood, BP, and Tourassi, GD. "Mutual information-based template matching scheme for detection of breast masses: from mammography to digital breast tomosynthesis." J Biomed Inform 44, no. 5 (October 2011): 815-823. Full Text Link to Item
- Chanyavanich, V, Das, SK, Lee, WR, and Lo, JY. "Knowledge-based IMRT treatment planning for prostate cancer." Med Phys 38, no. 5 (May 2011): 2515-2522. Full Text Link to Item
- Webb, LJ, Samei, E, Lo, JY, Baker, JA, Ghate, SV, Kim, C, Soo, MS, and Walsh, R. "Comparative performance of multiview stereoscopic and mammographic display modalities for breast lesion detection." Med Phys 38, no. 4 (April 2011): 1972-1980. Full Text Link to Item
- Shafer, CM, Seewaldt, VL, and Lo, JY. "Validation of a 3D hidden-Markov model for breast tissue segmentation and density estimation from MR and tomosynthesis images." Proceedings of the 2011 Biomedical Sciences and Engineering Conference: Image Informatics and Analytics in Biomedicine, BSEC 2011 (2011). Full Text
- Singh, S, Maxwell, J, Baker, JA, Nicholas, JL, and Lo, JY. "Computer-aided classification of breast masses: performance and interobserver variability of expert radiologists versus residents." Radiology 258, no. 1 (January 2011): 73-80. Full Text Link to Item
- Robinson, MD, Toth, CA, Lo, JY, and Farsiu, S. "Efficient fourier-wavelet super-resolution." IEEE Trans Image Process 19, no. 10 (October 2010): 2669-2681. Full Text Link to Item
- Ranger, NT, Lo, JY, and Samei, E. "A technique optimization protocol and the potential for dose reduction in digital mammography." Med Phys 37, no. 3 (March 2010): 962-969. Full Text Link to Item
- Shafer, CM, Samei, E, and Lo, JY. "The quantitative potential for breast tomosynthesis imaging." Med Phys 37, no. 3 (March 2010): 1004-1016. Full Text Link to Item
- Chawla, AS, Lo, JY, Baker, JA, and Samei, E. "Optimized image acquisition for breast tomosynthesis in projection and reconstruction space." Med Phys 36, no. 11 (November 2009): 4859-4869. Full Text Link to Item
- Saunders, RS, Samei, E, Lo, JY, and Baker, JA. "Can compression be reduced for breast tomosynthesis? Monte carlo study on mass and microcalcification conspicuity in tomosynthesis." Radiology 251, no. 3 (June 2009): 673-682. Full Text Link to Item
- Jesneck, JL, Mukherjee, S, Yurkovetsky, Z, Clyde, M, Marks, JR, Lokshin, AE, and Lo, JY. "Do serum biomarkers really measure breast cancer? (Published online)." BMC Cancer 9 (May 28, 2009): 164-. Full Text Link to Item
- Chawla, AS, Saunders, RS, Singh, S, Lo, JY, and Samei, E. "Towards optimized acquisition scheme for multiprojection correlation imaging of breast cancer." Acad Radiol 16, no. 4 (April 2009): 456-463. Full Text Link to Item
- Singh, S, Tourassi, GD, Baker, JA, Samei, E, and Lo, JY. "Automated breast mass detection in 3D reconstructed tomosynthesis volumes: a featureless approach." Med Phys 35, no. 8 (August 2008): 3626-3636. Full Text Link to Item
- Williams, MB, Raghunathan, P, More, MJ, Seibert, JA, Kwan, A, Lo, JY, Samei, E, Ranger, NT, Fajardo, LL, McGruder, A, McGruder, SM, Maidment, ADA, Yaffe, MJ, Bloomquist, A, and Mawdsley, GE. "Optimization of exposure parameters in full field digital mammography." Med Phys 35, no. 6 (June 2008): 2414-2423. Full Text Link to Item
- Floyd, CE, Kapadia, AJ, Bender, JE, Sharma, AC, Xia, JQ, Harrawood, BP, Tourassi, GD, Lo, JY, Crowell, AS, Kiser, MR, and Howell, CR. "Neutron-stimulated emission computed tomography of a multi-element phantom." Phys Med Biol 53, no. 9 (May 7, 2008): 2313-2326. Full Text Link to Item
- Xia, JQ, Lo, JY, Yang, K, Floyd, CE, and Boone, JM. "Dedicated breast computed tomography: volume image denoising via a partial-diffusion equation based technique." Med Phys 35, no. 5 (May 2008): 1950-1958. Full Text Link to Item
- Chawla, AS, Samei, E, Saunders, RS, Lo, JY, and Baker, JA. "A mathematical model platform for optimizing a multiprojection breast imaging system." Med Phys 35, no. 4 (April 2008): 1337-1345. Full Text Link to Item
- Mazurowski, MA, Habas, PA, Zurada, JM, Lo, JY, Baker, JA, and Tourassi, GD. "Training neural network classifiers for medical decision making: the effects of imbalanced datasets on classification performance." Neural Netw 21, no. 2-3 (March 2008): 427-436. Full Text Link to Item
- Karellas, A, Lo, JY, and Orton, CG. "Point/Counterpoint. Cone beam x-ray CT will be superior to digital x-ray tomosynthesis in imaging the breast and delineating cancer." Med Phys 35, no. 2 (February 2008): 409-411. Full Text Link to Item
- Karellas, A, Lo, JY, and Orton, CG. "Cone beam x-ray CT will be superior to digital x-ray tomosynthesis in imaging the breast and delineating cancer." MEDICAL PHYSICS 35, no. 2 (February 2008): 409-411. Full Text Link to Item
- Chen, Y, Lo, JY, and Dobbins, JT. "Impulse response and Modulation Transfer Function analysis for Shift-And-Add and Back Projection image reconstruction algorithms in Digital Breast Tomosynthesis (DBT)." Int J Funct Inform Personal Med 1, no. 2 (2008): 189-204. Full Text Link to Item
- Karellas, A, Lo, JY, and Orton, CG. "Cone beam x-ray CT will be superior to digital x-ray tomosynthesis in imaging the breast and delineating cancer." Medical Physics 35, no. 2 (2008): 409-411. Full Text
- Shafer, CM, Samei, E, Saunders, RS, Zerhouni, M, and Lo, JY. "Toward quantification of breast tomosynthesis imaging." MEDICAL IMAGING 2008: PHYSICS OF MEDICAL IMAGING, PTS 1-3 6913 (2008). Full Text Link to Item
- Chen, Y, Lo, JY, and Dobbins, JT. "Importance of point-by-point back projection correction for isocentric motion in digital breast tomosynthesis: relevance to morphology of structures such as microcalcifications." Med Phys 34, no. 10 (October 2007): 3885-3892. Full Text Link to Item
- Jesneck, JL, Lo, JY, and Baker, JA. "Breast mass lesions: computer-aided diagnosis models with mammographic and sonographic descriptors." Radiology 244, no. 2 (August 2007): 390-398. Full Text Link to Item
- Tourassi, GD, Harrawood, B, Singh, S, and Lo, JY. "Information-theoretic CAD system in mammography: entropy-based indexing for computational efficiency and robust performance." Med Phys 34, no. 8 (August 2007): 3193-3204. Full Text Link to Item
- Baydush, AH, Catarious, DM, Lo, JY, and Floyd, CE. "Incorporation of a Laguerre-Gauss channelized Hotelling observer for false-positive reduction in a mammographic mass CAD system." J Digit Imaging 20, no. 2 (June 2007): 196-202. Full Text Link to Item
- Samei, E, Stebbins, SA, Dobbins, JT, McAdams, HP, and Lo, JY. "Multiprojection correlation imaging for improved detection of pulmonary nodules." AJR Am J Roentgenol 188, no. 5 (May 2007): 1239-1245. Full Text Link to Item
- Chen, Y, Lo, JY, and III, JTD. "A comparison between traditional shift-and-add (SAA) and point-by-point back projection (BP) - Relevance to morphology of microcalcifications for isocentric motion in Digital Breast tomosynthesis (DBT)." Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE (2007): 563-569. Full Text
- Jr, CEF, Sharma, AC, Bender, JE, Kapadia, AJ, Xia, JQ, Harrawood, BP, Tourassi, GD, Lo, JY, Kiser, MR, Crowell, AS, Pedroni, RS, Macri, RA, Tajima, S, and Howell, CR. "Neutron stimulated emission computed tomography: Background corrections." Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 254, no. 2 (2007): 329-336. Full Text
- Singh, S, Tourassi, GD, and Lo, JY. "Breast mass detection in tomosynthesis projection images using information-theoretic similarity measures." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6514, no. PART 1 (2007). Full Text
- Singh, S, Tourassi, GD, and Lo, JY. "Breast mass detection in tomosynthesis projection images using information-theoretic similarity measures." MEDICAL IMAGING 2007: COMPUTER-AIDED DIAGNOSIS, PTS 1 AND 2 6514 (2007). Full Text Link to Item
- Tourassi, GD, Harrawood, B, Singh, S, Lo, JY, and Floyd, CE. "Evaluation of information-theoretic similarity measures for content-based retrieval and detection of masses in mammograms." Med Phys 34, no. 1 (January 2007): 140-150. Full Text Link to Item
- Jesneck, JL, Nolte, LW, Baker, JA, Floyd, CE, and Lo, JY. "Optimized approach to decision fusion of heterogeneous data for breast cancer diagnosis." Med Phys 33, no. 8 (August 2006): 2945-2954. Full Text Link to Item
- Floyd, CE, Bender, JE, Sharma, AC, Kapadia, A, Xia, J, Harrawood, B, Tourassi, GD, Lo, JY, Crowell, A, and Howell, C. "Introduction to neutron stimulated emission computed tomography." Phys Med Biol 51, no. 14 (July 21, 2006): 3375-3390. Full Text Link to Item
- Chen, Y, Lo, JY, Baker, JA, and III, JTD. "Gaussian frequency blending algorithm with Matrix Inversion Tomosynthesis (MITS) and Filtered Back Projection (FBP) for better digital breast tomosynthesis reconstruction." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6142 I (2006). Full Text
- Chen, Y, Lo, JY, and III, JTD. "Noise power spectrum analysis for several digital breast tomosynthesis reconstruction algorithms." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6142 III (2006). Full Text
- Jesneck, JL, Nolte, LW, Baker, JA, and Lo, JY. "The effect of data set size on computer-aided diagnosis of breast cancer: Comparing decision fusion to a linear discriminant." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6146 (2006). Full Text
- Jr, CEF, Bender, JE, Harrawood, B, Sharma, AC, Kapadia, A, Tourassi, GD, Lo, JY, and Howell, C. "Breast cancer diagnosis using neutron stimulated emission computed tomography: Dose and count requirements." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6142 II (2006). Full Text
- Sharma, A, Floyd, C, Harrawood, B, Tourassi, G, Kapadia, A, Bender, J, Lo, J, and Howell, C. "Rotating slat collimator design for high-energy near-field imaging." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6142 I (2006). Full Text
- Singh, S, Baydush, A, Harrawood, B, and Lo, J. "Mass detection in mammographic ROIs using Watson filters." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6146 (2006). Full Text
- Williams, MB, Raghunathan, P, Seibert, A, Kwan, A, Lo, J, Samei, E, Fajardo, L, Maidment, ADA, Yaffe, M, and Bloomquist, A. "Beam optimization for digital mammography - II." Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 4046 LNCS (2006): 273-280.
- Bilska-Wolak, AO, Floyd, CE, Lo, JY, and Baker, JA. "Computer aid for decision to biopsy breast masses on mammography: validation on new cases." Acad Radiol 12, no. 6 (June 2005): 671-680. Full Text Link to Item
- Samei, E, Lo, JY, Yoshizumi, TT, Jesneck, JL, Dobbins, JT, Floyd, CE, McAdams, HP, and Ravin, CE. "Comparative scatter and dose performance of slot-scan and full-field digital chest radiography systems." Radiology 235, no. 3 (June 2005): 940-949. Full Text Link to Item
- Baker, JA, Rosen, EL, Crockett, MM, and Lo, JY. "Accuracy of segmentation of a commercial computer-aided detection system for mammography." Radiology 235, no. 2 (May 2005): 385-390. Full Text Link to Item
- Saunders, RS, Samei, E, Jesneck, JL, and Lo, JY. "Physical characterization of a prototype selenium-based full field digital mammography detector." Med Phys 32, no. 2 (February 2005): 588-599. Full Text Link to Item
- Bissonnette, M, Hansroul, M, Masson, E, Savard, S, Cadieux, S, Warmoes, P, Gravel, D, Agopyan, J, Polischuk, B, Haerer, W, Mertelmeier, T, Lo, JY, Chen, Y, III, JTD, Jesneck, JL, and Singh, S. "Digital breast tomosynthesis using an amorphous selenium flat panel detector." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 5745, no. I (2005): 529-540. Full Text
- Chen, Y, Lo, JY, and III, JTD. "Impulse response analysis for several digital tomosynthesis mammography reconstruction algorithms." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 5745, no. I (2005): 541-549. Full Text
- Jesneck, JL, Saunders, RS, Samei, E, Xia, JQ, and Lo, JY. "Detector evaluation of a prototype amorphous selenium-based full field digital mammography system." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 5745, no. I (2005): 478-485. Full Text
- Markey, MK, and Lo, JY. "Issues in assessing multi-institutional performance of BI-RADS-based CAD systems." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 5747, no. II (2005): 858-865. Full Text
- Samei, E, Dobbins, JT, Lo, JY, and Tornai, MP. "A framework for optimising the radiographic technique in digital X-ray imaging." Radiat Prot Dosimetry 114, no. 1-3 (2005): 220-229. Full Text Link to Item
- Xia, JQ, Lo, JY, and Jr, CEF. "Characterization of scatter radiation of a breast phantom on siemens prototype FFDM with and without an anti-scatter grid." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 5745, no. II (2005): 1096-1102. Full Text
- Baker, JA, Lo, JY, Delong, DM, and Floyd, CE. "Computer-aided detection in screening mammography: variability in cues." Radiology 233, no. 2 (November 2004): 411-417. Full Text Link to Item
- Samei, E, Saunders, RS, Lo, JY, Dobbins, JT, Jesneck, JL, Floyd, CE, and Ravin, CE. "Fundamental imaging characteristics of a slot-scan digital chest radiographic system." Med Phys 31, no. 9 (September 2004): 2687-2698. Full Text Link to Item
- Fischer, EA, Lo, JY, and Markey, MK. "Bayesian networks of BI-RADS™ descriptors for breast lesion Classification." Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 26 IV (2004): 3031-3034.
- Jr, WHL, McKee, DW, Anderson, FR, and Lo, JY. "Breast cancer classification improvements using a new kernel function with evolutionary-programming-configured support vector machines." Proceedings of SPIE - The International Society for Optical Engineering 5370 II (2004): 880-887. Full Text
- Jr, WHL, Wong, L, McKee, D, Masters, T, Anderson, F, Raturi, A, and Lo, JY. "New results in computer aided diagnosis (CAD) of breast cancer using a recently developed SVM/GRNN oracle hybrid." Proceedings of SPIE - The International Society for Optical Engineering 5370 II (2004): 777-784. Full Text
- Baker, JA, Rosen, EL, Lo, JY, Gimenez, EI, Walsh, R, and Soo, MS. "Computer-aided detection (CAD) in screening mammography: sensitivity of commercial CAD systems for detecting architectural distortion." AJR Am J Roentgenol 181, no. 4 (October 2003): 1083-1088. Full Text Link to Item
- Bilska-Wolak, AO, Floyd, CE, Nolte, LW, and Lo, JY. "Application of likelihood ratio to classification of mammographic masses; performance comparison to case-based reasoning." Med Phys 30, no. 5 (May 2003): 949-958. Full Text Link to Item
- Markey, MK, Lo, JY, Tourassi, GD, and Floyd, CE. "Self-organizing map for cluster analysis of a breast cancer database." Artif Intell Med 27, no. 2 (February 2003): 113-127. Link to Item
- Bilska-Wolak, AO, Jr, CEF, and Lo, JY. "Prediction of breast biopsy outcome using a likelihood ratio classifier and biopsy cases from two medical centers." Proceedings of SPIE - The International Society for Optical Engineering 5032 III (2003): 1386-1391. Full Text
- Jr, WHL, McKee, D, Velazquez, R, Wong, L, Lo, JY, and Anderson, F. "Application of support vector machines to breast cancer screening using mammogram and clinical history data." Proceedings of SPIE - The International Society for Optical Engineering 5032 I (2003): 546-556. Full Text
- Jr, WHL, McKee, DW, Lo, JY, and Anderson, FR. "Improving the predictive value of mammography using a specialized evolutionary programming hybrid and fitness functions." Proceedings of SPIE - The International Society for Optical Engineering 5032 II (2003): 898-907. Full Text
- Lo, JY, Gavrielides, M, Markey, MK, and Jesneck, JL. "Computer-aided classification of breast microcalcification clusters: Merging of features from image processing and radiologists." Proceedings of SPIE - The International Society for Optical Engineering 5032 II (2003): 882-889. Full Text
- Tourassi, GD, Lo, JY, and Markey, MK. "Validation of a constraint satisfaction neural network for breast cancer diagnosis: New results from 1,030 cases." Proceedings of SPIE - The International Society for Optical Engineering 5032 I (2003): 207-214. Full Text
- Markey, MK, Lo, JY, and Floyd, CE. "Differences between computer-aided diagnosis of breast masses and that of calcifications." Radiology 223, no. 2 (May 2002): 489-493. Full Text Link to Item
- Gavrielides, MA, Lo, JY, and Floyd, CE. "Parameter optimization of a computer-aided diagnosis scheme for the segmentation of microcalcification clusters in mammograms." Med Phys 29, no. 4 (April 2002): 475-483. Full Text Link to Item
- Keogan, MT, Lo, JY, Freed, KS, Raptopoulos, V, Blake, S, Kamel, IR, Weisinger, K, Rosen, MP, and Nelson, RC. "Outcome analysis of patients with acute pancreatitis by using an artificial neural network." Acad Radiol 9, no. 4 (April 2002): 410-419. Link to Item
- Markey, MK, Lo, JY, Vargas-Voracek, R, Tourassi, GD, and Floyd, CE. "Perceptron error surface analysis: a case study in breast cancer diagnosis." Comput Biol Med 32, no. 2 (March 2002): 99-109. Link to Item
- Lo, JY, Markey, MK, Baker, JA, and Floyd, CE. "Cross-institutional evaluation of BI-RADS predictive model for mammographic diagnosis of breast cancer." AJR Am J Roentgenol 178, no. 2 (February 2002): 457-463. Full Text Link to Item
- Jr, WHL, Akanda, A, Lo, JY, Anderson, F, and Bryden, M. "Application of support vector machines to breast cancer screening using mammogram and history data." Proceedings of SPIE - The International Society for Optical Engineering 4684 I (2002): 636-642. Full Text
- Jr, WHL, Lo, JY, and Velázquez, R. "Using evolutionary programming to configure support vector machines for the diagnosis of breast cancer." Intelligent Engineering Systems Through Artificial Neural Networks 12 (2002): 249-254.
- Jr, WHL, McKee, DW, Lo, JY, and Anderson, F. "Improving mammogram screening using a bank of support vector machines (SVMs)." Intelligent Engineering Systems Through Artificial Neural Networks 12 (2002): 779-784.
- Land, WH, Bryden, M, Lo, JY, McKee, DW, and Anderson, FR. "Performance tradeoff between evolutionary computation (EC)/adaptive boosting (AB) hybrid and support vector machine breast cancer classification paradigms." Proceedings of the 2002 Congress on Evolutionary Computation, CEC 2002 1 (January 1, 2002): 187-192. Full Text
- Markey, MK, Lo, JY, Tourassi, GD, and Jr, CEF. "Cluster analysis of BI-RADS™ descriptions of biopsy-proven breast lesions." Proceedings of SPIE - The International Society for Optical Engineering 4684 I (2002): 363-370. Full Text
- Baydush, AH, Catarious, DM, Lo, JY, Abbey, CK, and Floyd, CE. "Computerized classification of suspicious regions in chest radiographs using subregion Hotelling observers." Med Phys 28, no. 12 (December 2001): 2403-2409. Full Text Link to Item
- Tourassi, GD, Markey, MK, Lo, JY, and Floyd, CE. "A neural network approach to breast cancer diagnosis as a constraint satisfaction problem." Med Phys 28, no. 5 (May 2001): 804-811. Full Text Link to Item
- Jr, LWH, Masters, T, Lo, JY, and McKee, DW. "Application of adaptive boosting to EP-derived multi-layer feedforward neural networks (MLFN) to improve benign/malignant breast cancer classification." Proceedings of SPIE - The International Society for Optical Engineering 4322, no. 3 (2001): 1717-1724. Full Text
- Jr, LWH, Masters, T, Lo, JY, and McKee, DW. "Application of evolutionary computation and neural network hybrids for breast cancer classification using mammogram and history data." Proceedings of the IEEE Conference on Evolutionary Computation, ICEC 2 (2001): 1147-1154.
- Floyd, CE, Lo, JY, and Tourassi, GD. "Case-based reasoning computer algorithm that uses mammographic findings for breast biopsy decisions." AJR Am J Roentgenol 175, no. 5 (November 2000): 1347-1352. Full Text Link to Item
- Gavrielides, MA, Lo, JY, Vargas-Voracek, R, and Floyd, CE. "Segmentation of suspicious clustered microcalcifications in mammograms." Med Phys 27, no. 1 (January 2000): 13-22. Full Text Link to Item
- Jr, WHL, Masters, T, and Lo, JY. "Application of a GRNN ORACLE to the intelligent combination of several breast cancer benign/malignant predictive paradigms." Proceedings of SPIE - The International Society for Optical Engineering 3979 (2000): I/--.
- Jr, WL, Masters, T, and Lo, J. "Application of a new Evolutionary Programming/Adaptive Boosting hybrid to breast cancer diagnosis." Proceedings of the IEEE Conference on Evolutionary Computation, ICEC 2 (2000): 1436-1442.
- Land, WH, Jr, MT, and Lo, JY. "Application of a GRNN oracle to the intelligent combination of several breast cancer benign/malignant predictive paradigms." Proc. SPIE - Int. Soc. Opt. Eng. (USA) 3979 (2000): 77-85. (Academic Article)
- Lo, JY, Land, WH, and Morrison, CT. "Evolutionary programming technique for reducing complexity of artificial neural networks for breast cancer diagnosis." MEDICAL IMAGING 2000: IMAGE PROCESSING, PTS 1 AND 2 3979 (2000): 153-158. Full Text Link to Item
- Lo, JY, Land, WH, and Morrison, CT. "Evolutionary programming technique for reducing complexity of artificial neural networks for breast cancer diagnosis." Proceedings of SPIE - The International Society for Optical Engineering 3979 (2000): I/--.
- Tourassi, GD, Floyd, CE, and Lo, JY. "Use of a constraint satisfaction neural network for breast cancer diagnosis and dynamic scenarios simulation." MEDICAL IMAGING 2000: IMAGE PROCESSING, PTS 1 AND 2 3979 (2000): 46-54. Full Text Link to Item
- Tourassi, GD, Jr, CEF, and Lo, JY. "Use of a constraint satisfaction neural network for breast cancer diagnosis and dynamic scenarios simulation." Proceedings of SPIE - The International Society for Optical Engineering 3979 (2000): I/--.
- Munley, MT, Lo, JY, Sibley, GS, Bentel, GC, Anscher, MS, and Marks, LB. "A neural network to predict symptomatic lung injury." Phys Med Biol 44, no. 9 (September 1999): 2241-2249. Link to Item
- Floyd, CE, Lo, JY, and Baker, JA. "Prediction of breast biopsy outcomes from mammographic findings." COMPUTER-AIDED DIAGNOSIS IN MEDICAL IMAGING 1182 (1999): 193-200. Link to Item
- Jr, CEF, Lo, JY, and Tourassi, GD. "Case-based reasoning as a computer aid to diagnosis." Proceedings of SPIE - The International Society for Optical Engineering 3661, no. I (1999): 486-489.
- Jr, WHL, Masters, T, Morrison, CT, and Lo, JY. "Application of a GRNN oracle to the intelligent combination of several breast cancer benign/malignant predictive paradigms." Intelligent Engineering Systems Through Artificial Neural Networks 9 (1999): 803-808.
- Lo, JY, Baker, JA, Kornguth, PJ, and Floyd, CE. "Effect of patient history data on the prediction of breast cancer from mammographic findings with artificial neural networks." Acad Radiol 6, no. 1 (January 1999): 10-15. Link to Item
- Lo, JY, Land, WH, and Morrison, CT. "Application of evolutionary programming and probabilistic neural networks to breast cancer diagnosis." Proceedings of the International Joint Conference on Neural Networks 5 (1999): 3712-3716.
- Lo, JY, and Floyd, CE. "Application of artificial neural networks for diagnosis of breast cancer." Proceedings of the 1999 Congress on Evolutionary Computation, CEC 1999 3 (January 1, 1999): 1755-1759. Full Text
- Lo, JY, and Floyd, CE. "Computer-aided diagnosis of breast cancer." COMPUTER-AIDED DIAGNOSIS IN MEDICAL IMAGING 1182 (1999): 221-225. Link to Item
- Tourassi, GD, Jr, CEF, and Lo, JY. "Constraint Satisfaction Neural Network for medical diagnosis." Proceedings of the International Joint Conference on Neural Networks 5 (1999): 3632-3635.
- Freed, KS, Lo, JY, Baker, JA, Floyd, CE, Low, VH, Seabourn, JT, and Nelson, RC. "Predictive model for the diagnosis of intraabdominal abscess." Acad Radiol 5, no. 7 (July 1998): 473-479. Link to Item
- Sakamoto, H, Lo, JYD, and Nishida, T. "QoS middleware for Internet multimedia streaming." NEC Tech. J. (Japan) 51, no. 8 (1998): 35-40. (Academic Article)
- Lo, JY, Baker, JA, Kornguth, PJ, Iglehart, JD, and Floyd, CE. "Predicting breast cancer invasion with artificial neural networks on the basis of mammographic features." Radiology 203, no. 1 (April 1997): 159-163. Full Text Link to Item
- Lo, JY, and Jr, CEF. "Self-organizing maps for analyzing mammographic findings." IEEE International Conference on Neural Networks - Conference Proceedings 4 (1997): 2472-2474.
- Floyd, CE, Patz, EF, Lo, JY, Vittitoe, NF, and Stambaugh, LE. "Diffuse nodular lung disease on chest radiographs: a pilot study of characterization by fractal dimension." AJR Am J Roentgenol 167, no. 5 (November 1996): 1185-1187. Full Text Link to Item
- Baker, JA, Kornguth, PJ, Lo, JY, and Floyd, CE. "Artificial neural network: improving the quality of breast biopsy recommendations." Radiology 198, no. 1 (January 1996): 131-135. Full Text Link to Item
- Jr, FCE, Lo, JY, Tourassi, GD, Baker, JA, Vitittoe, NF, and Vargas-Vorack, R. "Computer aided diagnosis in thoracic and mammographic radiology." Med. Imaging Technol. (Japan) 14, no. 6 (1996): 629-634. (Academic Article)
- Lo, JY, Kim, J, Baker, JA, and Jr, CEF. "Computer-aided diagnosis of mammography using an artificial neural network: Predicting the invasiveness of breast cancers from image features." Proceedings of SPIE - The International Society for Optical Engineering 2710 (1996): 725-732. Full Text
- Lo, JY, Baker, JA, Kornguth, PJ, and Floyd, CE. "Computer-aided diagnosis of breast cancer: artificial neural network approach for optimized merging of mammographic features." Acad Radiol 2, no. 10 (October 1995): 841-850. Link to Item
- Baker, JA, Kornguth, PJ, Lo, JY, Williford, ME, and Floyd, CE. "Breast cancer: prediction with artificial neural network based on BI-RADS standardized lexicon." Radiology 196, no. 3 (September 1995): 817-822. Full Text Link to Item
- LO, JY, GRISSON, AT, FLOYD, CE, and KORNGUTH, PJ. "COMPUTER-AIDED DIAGNOSIS OF MAMMOGRAMS USING AN ARTIFICIAL NEURAL NETWORK - MERGING OF STANDARDIZED INPUT FEATURES FROM THE ACR LEXICON." MEDICAL IMAGING 1995: IMAGE PROCESSING 2434 (1995): 571-578. Full Text Link to Item
- Mun, SK, Freedman, MT, Wu, YC, Lo, BS, Jr, CEF, Lo, JY, Chan, H-P, Helvie, MA, Petrick, N, Sahiner, B, Wei, D, Chakraborty, DP, Clarke, LP, Kallergi, M, Clark, B, and Kim, Y. "Academic consortium for the evaluation of computer-aided diagnosis (CADx) in mammography." Proceedings of SPIE - The International Society for Optical Engineering 2431 (1995): 442-446.
- Floyd, CE, Lo, JY, Yun, AJ, Sullivan, DC, and Kornguth, PJ. "Prediction of breast cancer malignancy using an artificial neural network." Cancer 74, no. 11 (December 1, 1994): 2944-2948. Link to Item
- Floyd, CE, Baydush, AH, Lo, JY, Bowsher, JE, and Ravin, CE. "Bayesian restoration of chest radiographs. Scatter compensation with improved signal-to-noise ratio." Invest Radiol 29, no. 10 (October 1994): 904-910. Link to Item
- Lo, JY, Floyd, CE, Baker, JA, and Ravin, CE. "Scatter compensation in digital chest radiography using the posterior beam stop technique." Med Phys 21, no. 3 (March 1994): 435-443. Full Text Link to Item
- LO, JY, BAYDUSH, AH, and FLOYD, CE. "SPATIALLY VARYING SCATTER COMPENSATION FOR CHEST RADIOGRAPHS USING A HYBRID MADALINE ARTIFICIAL NEURAL-NETWORK." IMAGE PROCESSING 2167 (1994): 601-611. Full Text Link to Item
- Baker, JA, Floyd, CE, Lo, JY, and Ravin, CE. "Observer evaluation of scatter subtraction for digital portable chest radiographs." Invest Radiol 28, no. 8 (August 1993): 667-670. Link to Item
- Jordan, LK, Floyd, CE, Lo, JY, and Ravin, CE. "Measurement of scatter fractions in erect posteroanterior and lateral chest radiography." Radiology 188, no. 1 (July 1993): 215-218. Full Text Link to Item
- Lo, JY, Floyd, CE, Baker, JA, and Ravin, CE. "An artificial neural network for estimating scatter exposures in portable chest radiography." Med Phys 20, no. 4 (July 1993): 965-973. Full Text Link to Item
- Floyd, CE, Baydush, AH, Lo, JY, Bowsher, JE, and Ravin, CE. "Scatter compensation for digital chest radiography using maximum likelihood expectation maximization." Invest Radiol 28, no. 5 (May 1993): 427-433. Link to Item
- BAYDUSH, AH, FLOYD, CE, LO, JY, BOWSHER, JE, and RAVIN, CE. "SCATTER REDUCTION IN PORTABLE DIGITAL CHEST RADIOGRAPHY WITH BAYESIAN IMAGE ESTIMATION." RADIOLOGY 185 (November 1992): 305-305. Link to Item
- LO, JY, FLOYD, CE, BOWSHER, JE, and RAVIN, CE. "SPATIALLY VARYING SCATTER ESTIMATION IN PORTABLE CHEST RADIOGRAPHY WITH AN ARTIFICIAL NEURAL NETWORK." RADIOLOGY 185 (November 1992): 300-300. Link to Item
- Floyd, CE, Baker, JA, Lo, JY, and Ravin, CE. "Measurement of scatter fractions in clinical bedside radiography." Radiology 183, no. 3 (June 1992): 857-861. Full Text Link to Item
- Floyd, CE, Baker, JA, Lo, JY, and Ravin, CE. "Posterior beam-stop method for scatter fraction measurement in digital radiography." Invest Radiol 27, no. 2 (February 1992): 119-123. Link to Item
- Floyd, CE, Lo, JY, Chotas, HG, and Ravin, CE. "Quantitative scatter measurement in digital radiography using a photostimulable phosphor imaging system." Med Phys 18, no. 3 (May 1991): 408-413. Full Text Link to Item
- Chotas, HG, Floyd, CE, Dobbins, JT, Lo, JY, and Ravin, CE. "Scatter fractions in AMBER imaging." Radiology 177, no. 3 (December 1990): 879-880. Full Text Link to Item
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Other Articles
- Robinson, MD, Farsiu, S, Lo, JY, Milanfar, P, and Toth, CA. "Efficient registration of aliased x-ray images." Conference Record - Asilomar Conference on Signals, Systems and Computers (2007): 215-219. Full Text
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- Teaching & Mentoring
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Recent Courses
- BME 394: Projects in Biomedical Engineering (GE) 2018
- BME 494: Projects in Biomedical Engineering (GE) 2018
- RROMP 301B: RADIOLOGY, RADIATION ONCOLOGY & MEDICAL PHYSICS 2018
- BME 493: Projects in Biomedical Engineering (GE) 2017
- MEDPHY 791: Independent Study in Medical Physics 2017
- EGR 393: Research Projects in Engineering 2016
- MEDPHY 751: Seminars in Medical Physics 2016
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Advising & Mentoring
- I have had the pleasure of serving as research advisor to over 40 students, including undergraduates, MS, PhD, and MD students. My lab is always open to students from all levels who want to learn more about medicine, engineering, and medical physics.
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