Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Texas Tech University Health Sciences Center, School of Medicine 2009
  • Ph.D., University of Kansas 2001
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Radiology, Radiology, Cardiothoracic Imaging, Radiology 2015 - 2020
  • Clinical Associate in the Department of Radiology, Radiology, Cardiothoracic Imaging, Radiology 2014 - 2015
• Research
• 

  Selected Grants

  • Xenon MRI in Pulmonary Hypertension awarded by National Institutes of Health 2021 - 2025
  • Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary Fibrosis awarded by National Institutes of Health 2015 - 2025
  • Oxidative Stress and Regional Airway Remodeling and Fibrosis in Obese Asthma awarded by National Institutes of Health 2020 - 2024
  • Automated acute pulmonary embolism assessment from CT awarded by Minnesota HealthSolutions 2022 - 2023
  • Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI awarded by National Institutes of Health 2011 - 2022
  • Pilot Study to Determine Health Effects of e-cigarette in Healthy Young Adults. awarded by University of Virginia - Charlottesville 2020 - 2022
  • Utilization of HP 129XE for Diagnosis in Pulmonary Fibrosis awarded by Radiological Society of North America 2018 - 2021
  • Non-invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129Xe MRI awarded by National Institutes of Health 2016 - 2020
• 

  External Relationships

  • Bard Peripheral Vascular, Inc.
  • Boehringer Ingleheim
  • Coreline
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Prabhu, Neel K., Megan K. Wong, Jacob A. Klapper, John C. Haney, Maciej A. Mazurowski, Joseph G. Mammarappallil, and Matthew G. Hartwig. “Computed Tomography Volumetrics for Size Matching in Lung Transplantation for Restrictive Disease.” Ann Thorac Surg, April 7, 2023. https://doi.org/10.1016/j.athoracsur.2023.03.033.
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    • O’Sullivan-Murphy, Bryan, Bastiaan Driehuys, and Joseph Mammarappallil. “MR Imaging for the Evaluation of Diffuse Lung Disease: Where Are We?” Radiol Clin North Am 60, no. 6 (November 2022): 1021–32. https://doi.org/10.1016/j.rcl.2022.06.007.
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    • Huang, Brian, John Sollee, Yong-Heng Luo, Ashwin Reddy, Zhusi Zhong, Jing Wu, Joseph Mammarappallil, et al. “Prediction of lung malignancy progression and survival with machine learning based on pre-treatment FDG-PET/CT.” Ebiomedicine 82 (August 2022): 104127. https://doi.org/10.1016/j.ebiom.2022.104127.
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    • Mummy, David G., Elianna A. Bier, Ziyi Wang, Jennifer Korzekwinski, Lake Morrison, Christina Barkauskas, H Page McAdams, Robert M. Tighe, Bastiaan Driehuys, and Joseph G. Mammarappallil. “Hyperpolarized 129Xe MRI and Spectroscopy of Gas-Exchange Abnormalities in Nonspecific Interstitial Pneumonia.” Radiology 301, no. 1 (October 2021): 211–20. https://doi.org/10.1148/radiol.2021204149.
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    • Wildman-Tobriner, Benjamin, Lawrence Ngo, Joseph G. Mammarappallil, Brandon Konkel, Jacob M. Johnson, and Mustafa R. Bashir. “Missed Incidental Pulmonary Embolism: Harnessing Artificial Intelligence to Assess Prevalence and Improve Quality Improvement Opportunities.” J Am Coll Radiol 18, no. 7 (July 2021): 992–99. https://doi.org/10.1016/j.jacr.2021.01.014.
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    • Wang, Ziyi, Leith Rankine, Elianna A. Bier, David Mummy, Junlan Lu, Alex Church, Robert M. Tighe, et al. “Using hyperpolarized 129Xe gas-exchange MRI to model the regional airspace, membrane, and capillary contributions to diffusing capacity.” J Appl Physiol (1985) 130, no. 5 (May 1, 2021): 1398–1409. https://doi.org/10.1152/japplphysiol.00702.2020.
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    • Gallo, Christopher J. R., Joseph G. Mammarappallil, David Y. Johnson, Hamid Chalian, James Ronald, Mustafa R. Bashir, and Charles Y. Kim. “Ferumoxytol-enhanced MR Venography of the Central Veins of the Thorax for the Evaluation of Stenosis and Occlusion in Patients with Renal Impairment.” Radiol Cardiothorac Imaging 2, no. 6 (December 2020): e200339. https://doi.org/10.1148/ryct.2020200339.
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    • He, Mu, Ziyi Wang, Leith Rankine, Sheng Luo, John Nouls, Rohan Virgincar, Joseph Mammarappallil, and Bastiaan Driehuys. “Generalized Linear Binning to Compare Hyperpolarized 129Xe Ventilation Maps Derived from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI.” Acad Radiol 27, no. 8 (August 2020): e193–203. https://doi.org/10.1016/j.acra.2019.10.016.
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    • Handran, Chauncy B., Lynne M. Hurwitz Koweek, and Joseph G. Mammarappallil. “Case 274: Cardiac Echinococcus.” Radiology 294, no. 2 (February 2020): 478–81. https://doi.org/10.1148/radiol.2019171881.
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    • Mammarappallil, Joseph G., Scott Shofer, Martha S. Carraway, Jesse Tucker, Samantha Womack, Maureen Ainslie, and H Cecil Charles. “Utilization of 19F MRI for Identification of Iraq-Afghanistan War Lung Injury.” Mil Med 185, no. Suppl 1 (January 7, 2020): 50–56. https://doi.org/10.1093/milmed/usz284.
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    • Rankine, Leith J., Ziyi Wang, Jennifer M. Wang, Mu He, H Page McAdams, Joseph Mammarappallil, Craig R. Rackley, Bastiaan Driehuys, and Robert M. Tighe. “129Xenon Gas Exchange Magnetic Resonance Imaging as a Potential Prognostic Marker for Progression of Idiopathic Pulmonary Fibrosis.” Ann Am Thorac Soc 17, no. 1 (January 2020): 121–25. https://doi.org/10.1513/AnnalsATS.201905-413RL.
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    • Wang, Ziyi, Elianna A. Bier, Aparna Swaminathan, Kishan Parikh, John Nouls, Mu He, Joseph G. Mammarappallil, Sheng Luo, Bastiaan Driehuys, and Sudarshan Rajagopal. “Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures.” Eur Respir J 54, no. 6 (December 2019). https://doi.org/10.1183/13993003.00831-2019.
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    • Handran, Chauncy B., Lynne M. Hurwitz Koweek, and Joseph G. Mammarappallil. “Case 274.” Radiology 293, no. 1 (October 2019): 232–34. https://doi.org/10.1148/radiol.2019171769.
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    • Mammarappallil, Joseph G., Leith Rankine, Jim M. Wild, and Bastiaan Driehuys. “New Developments in Imaging Idiopathic Pulmonary Fibrosis With Hyperpolarized Xenon Magnetic Resonance Imaging.” J Thorac Imaging 34, no. 2 (March 2019): 136–50. https://doi.org/10.1097/RTI.0000000000000392.
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    • Bier, Elianna A., Scott H. Robertson, Geoffry M. Schrank, Craig Rackley, Joseph G. Mammarappallil, Sudarshan Rajagopal, H Page McAdams, and Bastiaan Driehuys. “A protocol for quantifying cardiogenic oscillations in dynamic 129 Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis.” Nmr Biomed 32, no. 1 (January 2019): e4029. https://doi.org/10.1002/nbm.4029.
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    • Chalian, Hamid, Pegah Khoshpouri, Arya M. Iranmanesh, Joseph G. Mammarappallil, and Shervin Assari. “Lung cancer screening patient-provider discussion: Where do we stand and what are the associated factors?” Sage Open Med 7 (2019): 2050312119854265. https://doi.org/10.1177/2050312119854265.
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    • Patel, Bhavik N., Louis Rosenberg, Gregg Willcox, David Baltaxe, Mimi Lyons, Jeremy Irvin, Pranav Rajpurkar, et al. “Human-machine partnership with artificial intelligence for chest radiograph diagnosis.” Npj Digit Med 2 (2019): 111. https://doi.org/10.1038/s41746-019-0189-7.
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    • Patel, Bhavik N., Louis Rosenberg, Gregg Willcox, David Baltaxe, Mimi Lyons, Jeremy Irvin, Pranav Rajpurkar, et al. “Erratum: Author Correction: Human-machine partnership with artificial intelligence for chest radiograph diagnosis.” Npj Digit Med 2 (2019): 129. https://doi.org/10.1038/s41746-019-0198-6.
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    • Wang, Ziyi, Mu He, Elianna Bier, Leith Rankine, Geoffry Schrank, Sudarshan Rajagopal, Yuh-Chin Huang, et al. “Hyperpolarized 129 Xe gas transfer MRI: the transition from 1.5T to 3T.” Magn Reson Med 80, no. 6 (December 2018): 2374–83. https://doi.org/10.1002/mrm.27377.
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    • Artzner, Christoph, Melissa Daubert, Wendy Ehieli, David Kong, Joseph Mammarappallil, Konstantin Nikolaou, Daniel T. Boll, and Lynne Koweek. “Impact of computed tomography (CT)-derived fractional flow reserve on reader confidence for interpretation of coronary CT angiography.” Eur J Radiol 108 (November 2018): 242–48. https://doi.org/10.1016/j.ejrad.2018.09.035.
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    • Carney, John M., Joseph G. Mammarappallil, Thomas A. Sporn, and Elizabeth N. Pavlisko. “Dendriform pulmonary ossification leading to bilateral lung transplant: a case report.” Virchows Arch 473, no. 3 (September 2018): 379–83. https://doi.org/10.1007/s00428-018-2412-3.
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    • Kleeman, Lindsay T., Daniel Goltz, Thorsten M. Seyler, Joseph G. Mammarappallil, David E. Attarian, Samuel S. Wellman, and Michael P. Bolognesi. “Association Between Pseudotumor Formation and Patient Factors in Metal-on-Metal Total Hip Arthroplasty Population.” J Arthroplasty 33, no. 7S (July 2018): S259–64. https://doi.org/10.1016/j.arth.2018.03.039.
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    • Zapol, Warren M., H Cecil Charles, Andrew R. Martin, Rui C. Sá, Binglan Yu, Fumito Ichinose, Neil MacIntyre, et al. “Pulmonary Delivery of Therapeutic and Diagnostic Gases.” J Aerosol Med Pulm Drug Deliv 31, no. 2 (April 2018): 78–87. https://doi.org/10.1089/jamp.2017.1431.
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    • Griffin, Andrew, Ann Marie Navar, Lawrence Crawford, Joseph Mammarappallil, and Lynne Hurwitz Koweek. “A case of spontaneous coronary artery dissection diagnosed by coronary computed tomography angiography.” J Cardiovasc Comput Tomogr 12, no. 1 (2018): 88–89. https://doi.org/10.1016/j.jcct.2017.09.005.
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    • Mammarappallil, Joseph G., Thorsten M. Seyler, Leon Lenchik, Scott D. Wuertzer, and Johannes F. Plate. “Impact of Fluoroscopically Guided Bone Biopsy on Antibiotic Management of Osteomyelitis in the Lower Extremity.” J Surg Orthop Adv 27, no. 4 (2018): 277–80.
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    • Tailor, Tina D., Joseph G. Mammarappallil, and Jared D. Christensen. “Altered Nulling of Myocardium and Blood Pool.” J Thorac Imaging 32, no. 1 (January 2017): W1–2. https://doi.org/10.1097/RTI.0000000000000234.
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    • Dahhan, Talal, Shiv S. Kaushik, Mu He, Joseph G. Mammarappallil, Victor F. Tapson, Holman P. McAdams, Thomas A. Sporn, Bastiaan Driehuys, and Sudarshan Rajagopal. “Abnormalities in hyperpolarized (129)Xe magnetic resonance imaging and spectroscopy in two patients with pulmonary vascular disease.” Pulm Circ 6, no. 1 (March 2016): 126–31. https://doi.org/10.1086/685110.
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    • Mammarappallil, Joseph G., Kevin D. Hiatt, William Vincent, and Michael A. Bettmann. “How accurate is the label "allergic to iodinated contrast agents"?” Acta Radiol 57, no. 1 (January 2016): 47–50. https://doi.org/10.1177/0284185114568049.
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    • Mammarappallil, Joseph G., Sarah A. Anderson, Kerry A. Danelson, Joel A. Stitzel, and Caroline Chiles. “Estimation of Pleural Fluid Volumes on Chest Radiography Using Computed Tomography Volumetric Analysis: An Update of the Visual Prediction Rule.” J Thorac Imaging 30, no. 5 (September 2015): 336–39. https://doi.org/10.1097/RTI.0000000000000147.
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    • Mammarappallil, Joseph G., Kevin D. Hiatt, Qiqing Ge, and Hollins P. Clark. “Computed tomography fluoroscopy versus conventional computed tomography guidance for biopsy of intrathoracic lesions: a retrospective review of 1143 consecutive procedures.” J Thorac Imaging 29, no. 6 (November 2014): 340–43. https://doi.org/10.1097/RTI.0000000000000109.
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    • Anderson, S. A., K. A. Danelson, J. G. Mammarappallil, C. Chiles, and J. D. Stitzel. “A semiautomatic method of quantifying pleural effusions using computed tomography scans.” Biomedical Sciences Instrumentation 49 (January 1, 2013): 13–19.
    • Anderson, Sarah A., Kerry A. Danelson, Joseph G. Mammarappallil, Caroline Chiles, and Joel D. Stitzel. “Semiautomatic method of quantifying pleural effusions using computed tomography scans - biomed 2013.” Biomed Sci Instrum 49 (2013): 13–19.
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    • Gupta, P., J. G. Mammarappallil, C. Chiles, and D. W. Entrikin. “CT Angiography of the Aorta and Aortic Diseases.” Current Cardiovascular Imaging Reports 5, no. 5 (October 1, 2012): 337–51. https://doi.org/10.1007/s12410-012-9156-2.
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    • Frezza, Eldo E., Joseph G. Mammarappallil, Chance Witt, Cai Wei, and Mitchell S. Wachtel. “Value of routine postoperative gastrographin contrast swallow studies after laparoscopic gastric banding.” Arch Surg 144, no. 8 (August 2009): 766–69. https://doi.org/10.1001/archsurg.2009.138.
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    • Mammarappallil, J. G., and E. A. Elsinghorst. “Epithelial cell adherence mediated by the enterotoxigenic Escherichia coli tia protein.” Infect Immun 68, no. 12 (December 2000): 6595–6601. https://doi.org/10.1128/IAI.68.12.6595-6601.2000.
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  • Conference Papers

    • Bier, Elianna A., Fawaz Alenezi, Junlan Lu, Ziyi Wang, Joseph G. Mammarappallil, Bryan O’Sullivan-Murphy, Alaattin Erkanli, Bastiaan Driehuys, and Sudarshan Rajagopal. “Noninvasive diagnosis of pulmonary hypertension with hyperpolarised 129Xe magnetic resonance imaging and spectroscopy.” In Erj Open Res, Vol. 8, 2022. https://doi.org/10.1183/23120541.00035-2022.
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