Scholars@Duke

• Research
• 

  Selected Grants

  • Parsons UNC Interinstitutional Agreement awarded by University of North Carolina - Chapel Hill 2021 - 2022
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Dao, Tina H., Ramzi Alsallaq, Joshua B. Parsons, Jose Ferrolino, Randall T. Hayden, Jeffrey E. Rubnitz, Iftekhar M. Rafiqullah, et al. “Vancomycin Heteroresistance and Clinical Outcomes in Bloodstream Infections Caused by Coagulase-Negative Staphylococci.” Antimicrobial Agents and Chemotherapy 64, no. 11 (October 20, 2020). https://doi.org/10.1128/aac.00944-20.
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    • Parsons, Joshua B., Matthew W. Frank, Marc J. Eleveld, Joost Schalkwijk, Tyler C. Broussard, Marien I. de Jonge, and Charles O. Rock. “A thioesterase bypasses the requirement for exogenous fatty acids in the plsX deletion of Streptococcus pneumoniae.” Molecular Microbiology 96, no. 1 (April 2015): 28–41. https://doi.org/10.1111/mmi.12916.
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    • Parsons, Joshua B., Jiangwei Yao, Matthew W. Frank, and Charles O. Rock. “FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus.” Antimicrobial Agents and Chemotherapy 59, no. 2 (February 2015): 849–58. https://doi.org/10.1128/aac.04179-14.
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    • Parsons, Joshua B., Tyler C. Broussard, Jeffrey L. Bose, Jason W. Rosch, Pamela Jackson, Chitra Subramanian, and Charles O. Rock. “Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus.” Proceedings of the National Academy of Sciences of the United States of America 111, no. 29 (July 7, 2014): 10532–37. https://doi.org/10.1073/pnas.1408797111.
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    • Zheng, Zhong, Joshua B. Parsons, Rajendra Tangallapally, Weixing Zhang, Charles O. Rock, and Richard E. Lee. “Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening.” Bioorganic & Medicinal Chemistry Letters 24, no. 11 (June 2014): 2585–88. https://doi.org/10.1016/j.bmcl.2014.03.033.
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    • Parsons, Joshua B., Matthew W. Frank, Pamela Jackson, Chitra Subramanian, and Charles O. Rock. “Incorporation of extracellular fatty acids by a fatty acid kinase-dependent pathway in Staphylococcus aureus.” Molecular Microbiology 92, no. 2 (April 2014): 234–45. https://doi.org/10.1111/mmi.12556.
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    • Parsons, Joshua B., Jiangwei Yao, Pamela Jackson, Matthew Frank, and Charles O. Rock. “Phosphatidylglycerol homeostasis in glycerol-phosphate auxotrophs of Staphylococcus aureus.” Bmc Microbiology 13 (November 16, 2013): 260. https://doi.org/10.1186/1471-2180-13-260.
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    • Parsons, Joshua B., Matthew W. Frank, Jason W. Rosch, and Charles O. Rock. “Staphylococcus aureus fatty acid auxotrophs do not proliferate in mice.” Antimicrobial Agents and Chemotherapy 57, no. 11 (November 2013): 5729–32. https://doi.org/10.1128/aac.01038-13.
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    • Parsons, Joshua B., and Charles O. Rock. “Bacterial lipids: metabolism and membrane homeostasis.” Progress in Lipid Research 52, no. 3 (July 2013): 249–76. https://doi.org/10.1016/j.plipres.2013.02.002.
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    • Parsons, Joshua B., Maciej Kukula, Pamela Jackson, Mark Pulse, Jerry W. Simecka, David Valtierra, William J. Weiss, Nachum Kaplan, and Charles O. Rock. “Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252.” Antimicrobial Agents and Chemotherapy 57, no. 5 (May 2013): 2182–90. https://doi.org/10.1128/aac.02307-12.
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    • Parsons, Joshua B., Jiangwei Yao, Matthew W. Frank, Pamela Jackson, and Charles O. Rock. “Membrane disruption by antimicrobial fatty acids releases low-molecular-weight proteins from Staphylococcus aureus.” Journal of Bacteriology 194, no. 19 (October 2012): 5294–5304. https://doi.org/10.1128/jb.00743-12.
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    • Parsons, Joshua B., and Charles O. Rock. “Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?” Current Opinion in Microbiology 14, no. 5 (October 2011): 544–49. https://doi.org/10.1016/j.mib.2011.07.029.
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    • Parsons, Joshua B., Matthew W. Frank, Chitra Subramanian, Panatda Saenkham, and Charles O. Rock. “Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors.” Proceedings of the National Academy of Sciences of the United States of America 108, no. 37 (September 2011): 15378–83. https://doi.org/10.1073/pnas.1109208108.
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    • Parsons, Joshua B., Andrew D. Lawrence, Kirsty J. McLean, Andrew W. Munro, Stephen E. J. Rigby, and Martin J. Warren. “Characterisation of PduS, the pdu metabolosome corrin reductase, and evidence of substructural organisation within the bacterial microcompartment.” Plos One 5, no. 11 (November 16, 2010): e14009. https://doi.org/10.1371/journal.pone.0014009.
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    • Parsons, Joshua B., Stefanie Frank, David Bhella, Mingzhi Liang, Michael B. Prentice, Daniel P. Mulvihill, and Martin J. Warren. “Synthesis of empty bacterial microcompartments, directed organelle protein incorporation, and evidence of filament-associated organelle movement.” Molecular Cell 38, no. 2 (April 2010): 305–15. https://doi.org/10.1016/j.molcel.2010.04.008.
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    • Heldt, Dana, Stefanie Frank, Arefeh Seyedarabi, Dimitrios Ladikis, Joshua B. Parsons, Martin J. Warren, and Richard W. Pickersgill. “Structure of a trimeric bacterial microcompartment shell protein, EtuB, associated with ethanol utilization in Clostridium kluyveri.” The Biochemical Journal 423, no. 2 (September 25, 2009): 199–207. https://doi.org/10.1042/bj20090780.
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    • Sriramulu, Dinesh Diraviam, Mingzhi Liang, Diana Hernandez-Romero, Evelyne Raux-Deery, Heinrich Lünsdorf, Joshua B. Parsons, Martin J. Warren, and Michael B. Prentice. “Lactobacillus reuteri DSM 20016 produces cobalamin-dependent diol dehydratase in metabolosomes and metabolizes 1,2-propanediol by disproportionation.” Journal of Bacteriology 190, no. 13 (July 2008): 4559–67. https://doi.org/10.1128/jb.01535-07.
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    • Parsons, Joshua B., Sriramulu D. Dinesh, Evelyne Deery, Helen K. Leech, Amanda A. Brindley, Dana Heldt, Steffanie Frank, et al. “Biochemical and structural insights into bacterial organelle form and biogenesis.” The Journal of Biological Chemistry 283, no. 21 (May 2008): 14366–75. https://doi.org/10.1074/jbc.m709214200.
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