Scholars@Duke
Joshua James Siglin

Joshua James Siglin

Assistant Professor of Radiation Oncology
Radiation Oncology

Selected Publications

Comprehensive review of implications of COVID-19 on clinical outcomes of cancer patients and management of solid tumors during the pandemic.

Journal Article Cancer Med · December 2020 Coronavirus disease-2019 (COVID-19) has emerged as a novel infection which has spread rapidly across the globe and currently presents a grave threat to the health of vulnerable patient populations like those with malignancy, elderly, and immunocompromised. ... Full text Link to item Cite

Bevacizumab and re-irradiation for recurrent high grade gliomas: does sequence matter?

Journal Article J Neurooncol · December 2018 PURPOSE/OBJECTIVES: We report the outcomes of the largest cohort to date of patients receiving both bevacizumab (BEV) and fractionated stereotactic radiotherapy (FSRT) for progressive or recurrent high grade glioma (HGG). Furthermore, the sequence of these ... Full text Link to item Cite

Re-resection for recurrent high-grade glioma in the setting of re-irradiation: more is not always better.

Journal Article J Neurooncol · September 2015 The optimal treatment for patients with recurrent high grade glioma (HGG) remains controversial. Available therapies include surgery, re-irradiation, alternating electric fields or systemic therapy. Here we investigate whether re-resection will improve sur ... Full text Link to item Cite

Active Breathing Coordinator reduces radiation dose to the heart and preserves local control in patients with left breast cancer: report of a prospective trial.

Journal Article Pract Radiat Oncol · 2015 PURPOSE: Incidental radiation dose to the heart and lung during breast radiation therapy (RT) has been associated with an increased risk of cardiopulmonary morbidity. We conducted a prospective trial to determine if RT with the Active Breathing Coordinator ... Full text Link to item Cite

Optimizing patient positioning for intensity modulated radiation therapy in hippocampal-sparing whole brain radiation therapy.

Journal Article Pract Radiat Oncol · 2014 PURPOSE: Sparing the hippocampus during whole brain radiation therapy (WBRT) offers potential neurocognitive benefits. However, previously reported intensity modulated radiation therapy (IMRT) plans use multiple noncoplanar beams for treatment delivery. An ... Full text Link to item Cite

Evaluating changes in radiation treatment volumes from post-operative to same-day planning MRI in High-grade gliomas.

Journal Article Radiat Oncol · December 21, 2012 BACKGROUND: Adjuvant radiation therapy (RT) with temozolomide (TMZ) is standard of care for high grade gliomas (HGG) patients. RT is commonly started 3 to 5 weeks after surgery. The deformation of the tumor bed and brain from surgery to RT is poorly studie ... Full text Link to item Cite

Stereotactic radiotherapy for trigeminal schwannomas.

Journal Article Neurosurgery · August 2012 BACKGROUND: Data on radiotherapy for trigeminal schwannomas (TSs) and comparison of stereotactic radiosurgery (SRS) with fractionated stereotactic radiotherapy (FSRT) are limited. OBJECTIVE: We present a large retrospective review of our institutional expe ... Full text Link to item Cite

Weight gain, metabolic syndrome, and breast cancer recurrence: are dietary recommendations supported by the data?

Journal Article Int J Breast Cancer · 2012 Metabolic syndrome, which can include weight gain and central obesity, elevated serum insulin and glucose, and insulin resistance, has been strongly associated with breast cancer recurrence and worse outcomes after treatment. Epidemiologic and prospective ... Full text Link to item Cite