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Joshua M Wilson

Assistant Professor of Radiology
Radiology
2424 Erwin Road, Suite 302, DUMC 2731 - Rai Labs, Durham 27710
2424 Erwin Road, Suite 302, Durham 27705

Selected Publications


Medical Physics Leadership Academy Journal Club (Leadership Club) program: Two-year review in building a community of leaders.

Journal Article Journal of applied clinical medical physics · November 2023 The American Association of Physicists in Medicine began the Medical Physics Leadership Academy Journal Club in the fall of 2020. The initiative was launched to provide a forum for medical physicists to learn about leadership topics using published materia ... Full text Cite

Evaluation of the impact of a novel denoising algorithm on image quality in dual-energy abdominal CT of obese patients.

Journal Article Eur Radiol · October 2023 OBJECTIVES: Evaluate a novel algorithm for noise reduction in obese patients using dual-source dual-energy (DE) CT imaging. METHODS: Seventy-nine patients with contrast-enhanced abdominal imaging (54 women; age: 58 ± 14 years; BMI: 39 ± 5 kg/m2, range: 35- ... Full text Open Access Link to item Cite

Patient-Informed Organ Dose Estimation in Clinical CT: Implementation and Effective Dose Assessment in 1048 Clinical Patients.

Journal Article AJR Am J Roentgenol · March 2021 OBJECTIVE. The purpose of this study is to comprehensively implement a patient-informed organ dose monitoring framework for clinical CT and compare the effective dose (ED) according to the patient-informed organ dose with ED according to the dose-length pr ... Full text Open Access Link to item Cite

Technical Note: Validation of TG 233 phantom methodology to characterize noise and dose in patient CT data.

Journal Article Med Phys · April 2020 PURPOSE: Phantoms are useful tools in diagnostic CT, but practical limitations reduce phantoms to being only a limited patient surrogate. Furthermore, a phantom with a single cross sectional area cannot be used to evaluate scanner performance in modern CT ... Full text Open Access Link to item Cite

Organ doses from CT localizer radiographs: Development, validation, and application of a Monte Carlo estimation technique.

Journal Article Med Phys · November 2019 PURPOSE: The purpose of this study was to simulate and validate organ doses from different computed tomography (CT) localizer radiograph geometries using Monte Carlo methods for a population of patients. METHODS: A Monte Carlo method was developed to estim ... Full text Open Access Link to item Cite

Expanding the Concept of Diagnostic Reference Levels to Noise and Dose Reference Levels in CT.

Journal Article AJR Am J Roentgenol · October 2019 OBJECTIVE. Diagnostic reference levels were developed as guidance for radiation dose in medical imaging and, by inference, diagnostic quality. The objective of this work was to expand the concept of diagnostic reference levels to explicitly include noise o ... Full text Open Access Link to item Cite

Automated quality control assessment of clinical chest images.

Journal Article Med Phys · October 2018 PURPOSE: The purpose of this study was to determine whether a proposed suite of objective image quality metrics for digital chest radiographs is useful for monitoring image quality in a clinical setting unique from the one where the metrics were developed. ... Full text Link to item Cite

Image noise and dose performance across a clinical population: Patient size adaptation as a metric of CT performance.

Journal Article Med Phys · June 2017 PURPOSE: Modern CT systems adjust X-ray flux accommodating for patient size to achieve certain image noise values. The effectiveness of this adaptation is an important aspect of CT performance and should ideally be characterized in the context of real pati ... Full text Open Access Link to item Cite

Variability in Radiation Dose From Repeat Identical CT Examinations: Longitudinal Analysis of 2851 Patients Undergoing 12,635 Thoracoabdominal CT Scans in an Academic Health System.

Journal Article AJR Am J Roentgenol · June 2017 OBJECTIVE: The purpose of this study was to conduct longitudinal analyses of radiation dose data from adult patients undergoing clinically indicated, repeat identical thoracoabdominal CT examinations. MATERIALS AND METHODS: Radiation dose data were electro ... Full text Link to item Cite

Adaptability index: quantifying CT tube current modulation performance from dose and quality informatics

Journal Article Proc. SPIE 10132, Medical Imaging 2017: Physics of Medical Imaging, 101322N (March 9, 2017) · March 9, 2017 The balance between risk and benefit in modern CT scanners is governed by the automatic adaptation mechanisms that adjust x-ray flux for accommodating patient size to achieve certain image noise values. The effectiveness of this adaptation is an important ... Full text Open Access Link to item Cite

SU-F-I-48: Variability in CT Scanning Over-Range Across Clinical Operation.

Conference Med Phys · June 2016 PURPOSE: Inconsistency in the scan range for a given protocol can be a source of variability in patient dose. The purpose of this study was to determine the variability in the over-scan length in clinical CT operation for chest and abdominopelvic (A&P) pro ... Full text Link to item Cite

Virtual Monochromatic Images from Dual-Energy Multidetector CT: Variance in CT Numbers from the Same Lesion between Single-Source Projection-based and Dual-Source Image-based Implementations.

Journal Article Radiology · April 2016 PURPOSE: To determine the variance in virtual monochromatic computed tomography (CT) numbers from the same lesion, comparing the two clinically available dual-energy multidetector CT hardware implementations (single-source projection-based and dual-source ... Full text Link to item Cite

Effects of automatic tube potential selection on radiation dose index, image quality, and lesion detectability in pediatric abdominopelvic CT and CTA: a phantom study.

Journal Article Eur Radiol · January 2016 OBJECTIVES: To assess the effect of automatic tube potential selection (ATPS) on radiation dose, image quality, and lesion detectability in paediatric abdominopelvic CT and CT angiography (CTA). METHODS: A paediatric modular phantom with contrast inserts w ... Full text Link to item Cite

Characteristic image quality of a third generation dual-source MDCT scanner: Noise, resolution, and detectability.

Journal Article Med Phys · August 2015 PURPOSE: The purpose of this work was to assess the inherent image quality characteristics of a new multidetector computed tomography system in terms of noise, resolution, and detectability index as a function of image acquisition and reconstruction for a ... Full text Link to item Cite

Implementation of the ACR Dose Index Registry.

Journal Article J Am Coll Radiol · March 2015 Full text Link to item Cite

Dual-energy MDCT in hypervascular liver tumors: effect of body size on selection of the optimal monochromatic energy level.

Journal Article AJR Am J Roentgenol · December 2014 OBJECTIVE: The purpose of this article is to investigate the effect of body size on the selection of optimal monochromatic energy level for maximizing the conspicuity of hypervascular liver tumors during late hepatic arterial phase using dual-energy MDCT. ... Full text Link to item Cite

Medical Physics Leadership Academy Journal Club (Leadership Club) program: Two-year review in building a community of leaders.

Journal Article Journal of applied clinical medical physics · November 2023 The American Association of Physicists in Medicine began the Medical Physics Leadership Academy Journal Club in the fall of 2020. The initiative was launched to provide a forum for medical physicists to learn about leadership topics using published materia ... Full text Cite

Evaluation of the impact of a novel denoising algorithm on image quality in dual-energy abdominal CT of obese patients.

Journal Article Eur Radiol · October 2023 OBJECTIVES: Evaluate a novel algorithm for noise reduction in obese patients using dual-source dual-energy (DE) CT imaging. METHODS: Seventy-nine patients with contrast-enhanced abdominal imaging (54 women; age: 58 ± 14 years; BMI: 39 ± 5 kg/m2, range: 35- ... Full text Open Access Link to item Cite

Patient-Informed Organ Dose Estimation in Clinical CT: Implementation and Effective Dose Assessment in 1048 Clinical Patients.

Journal Article AJR Am J Roentgenol · March 2021 OBJECTIVE. The purpose of this study is to comprehensively implement a patient-informed organ dose monitoring framework for clinical CT and compare the effective dose (ED) according to the patient-informed organ dose with ED according to the dose-length pr ... Full text Open Access Link to item Cite

Technical Note: Validation of TG 233 phantom methodology to characterize noise and dose in patient CT data.

Journal Article Med Phys · April 2020 PURPOSE: Phantoms are useful tools in diagnostic CT, but practical limitations reduce phantoms to being only a limited patient surrogate. Furthermore, a phantom with a single cross sectional area cannot be used to evaluate scanner performance in modern CT ... Full text Open Access Link to item Cite

Organ doses from CT localizer radiographs: Development, validation, and application of a Monte Carlo estimation technique.

Journal Article Med Phys · November 2019 PURPOSE: The purpose of this study was to simulate and validate organ doses from different computed tomography (CT) localizer radiograph geometries using Monte Carlo methods for a population of patients. METHODS: A Monte Carlo method was developed to estim ... Full text Open Access Link to item Cite

Expanding the Concept of Diagnostic Reference Levels to Noise and Dose Reference Levels in CT.

Journal Article AJR Am J Roentgenol · October 2019 OBJECTIVE. Diagnostic reference levels were developed as guidance for radiation dose in medical imaging and, by inference, diagnostic quality. The objective of this work was to expand the concept of diagnostic reference levels to explicitly include noise o ... Full text Open Access Link to item Cite

Automated quality control assessment of clinical chest images.

Journal Article Med Phys · October 2018 PURPOSE: The purpose of this study was to determine whether a proposed suite of objective image quality metrics for digital chest radiographs is useful for monitoring image quality in a clinical setting unique from the one where the metrics were developed. ... Full text Link to item Cite

Image noise and dose performance across a clinical population: Patient size adaptation as a metric of CT performance.

Journal Article Med Phys · June 2017 PURPOSE: Modern CT systems adjust X-ray flux accommodating for patient size to achieve certain image noise values. The effectiveness of this adaptation is an important aspect of CT performance and should ideally be characterized in the context of real pati ... Full text Open Access Link to item Cite

Variability in Radiation Dose From Repeat Identical CT Examinations: Longitudinal Analysis of 2851 Patients Undergoing 12,635 Thoracoabdominal CT Scans in an Academic Health System.

Journal Article AJR Am J Roentgenol · June 2017 OBJECTIVE: The purpose of this study was to conduct longitudinal analyses of radiation dose data from adult patients undergoing clinically indicated, repeat identical thoracoabdominal CT examinations. MATERIALS AND METHODS: Radiation dose data were electro ... Full text Link to item Cite

Adaptability index: quantifying CT tube current modulation performance from dose and quality informatics

Journal Article Proc. SPIE 10132, Medical Imaging 2017: Physics of Medical Imaging, 101322N (March 9, 2017) · March 9, 2017 The balance between risk and benefit in modern CT scanners is governed by the automatic adaptation mechanisms that adjust x-ray flux for accommodating patient size to achieve certain image noise values. The effectiveness of this adaptation is an important ... Full text Open Access Link to item Cite

SU-F-I-48: Variability in CT Scanning Over-Range Across Clinical Operation.

Conference Med Phys · June 2016 PURPOSE: Inconsistency in the scan range for a given protocol can be a source of variability in patient dose. The purpose of this study was to determine the variability in the over-scan length in clinical CT operation for chest and abdominopelvic (A&P) pro ... Full text Link to item Cite

Virtual Monochromatic Images from Dual-Energy Multidetector CT: Variance in CT Numbers from the Same Lesion between Single-Source Projection-based and Dual-Source Image-based Implementations.

Journal Article Radiology · April 2016 PURPOSE: To determine the variance in virtual monochromatic computed tomography (CT) numbers from the same lesion, comparing the two clinically available dual-energy multidetector CT hardware implementations (single-source projection-based and dual-source ... Full text Link to item Cite

Effects of automatic tube potential selection on radiation dose index, image quality, and lesion detectability in pediatric abdominopelvic CT and CTA: a phantom study.

Journal Article Eur Radiol · January 2016 OBJECTIVES: To assess the effect of automatic tube potential selection (ATPS) on radiation dose, image quality, and lesion detectability in paediatric abdominopelvic CT and CT angiography (CTA). METHODS: A paediatric modular phantom with contrast inserts w ... Full text Link to item Cite

Characteristic image quality of a third generation dual-source MDCT scanner: Noise, resolution, and detectability.

Journal Article Med Phys · August 2015 PURPOSE: The purpose of this work was to assess the inherent image quality characteristics of a new multidetector computed tomography system in terms of noise, resolution, and detectability index as a function of image acquisition and reconstruction for a ... Full text Link to item Cite

Implementation of the ACR Dose Index Registry.

Journal Article J Am Coll Radiol · March 2015 Full text Link to item Cite

Dual-energy MDCT in hypervascular liver tumors: effect of body size on selection of the optimal monochromatic energy level.

Journal Article AJR Am J Roentgenol · December 2014 OBJECTIVE: The purpose of this article is to investigate the effect of body size on the selection of optimal monochromatic energy level for maximizing the conspicuity of hypervascular liver tumors during late hepatic arterial phase using dual-energy MDCT. ... Full text Link to item Cite

Dual-energy multi-detector row CT with virtual monochromatic imaging for improving patient-to-patient uniformity of aortic enhancement during CT angiography: an in vitro and in vivo study.

Journal Article Radiology · September 2014 PURPOSE: To determine whether virtual monochromatic imaging from a dual-energy acquisition can improve patient-to-patient uniformity of aortic enhancement during multi-detector row computed tomographic (CT) angiography. MATERIALS AND METHODS: This retrospe ... Full text Link to item Cite

Impact of dual-energy multi-detector row CT with virtual monochromatic imaging on renal cyst pseudoenhancement: in vitro and in vivo study.

Journal Article Radiology · September 2014 PURPOSE: To investigate whether dual-energy multi-detector row computed tomography (CT) with virtual monochromatic imaging can overcome renal cyst pseudoenhancement in a phantom experiment and a clinical study. MATERIALS AND METHODS: This retrospective sin ... Full text Link to item Cite

Assessment of volumetric noise and resolution performance for linear and nonlinear CT reconstruction methods.

Journal Article Med Phys · July 2014 PURPOSE: For nonlinear iterative image reconstructions (IR), the computed tomography (CT) noise and resolution properties can depend on the specific imaging conditions, such as lesion contrast and image noise level. Therefore, it is imperative to develop a ... Full text Link to item Cite

WE-D-18A-02: Performance Evaluation of Automatic Exposure Control (AEC) Across 12 Clinical CT Systems.

Journal Article Med Phys · June 2014 PURPOSE: Automatic exposure control (AEC) is not typically evaluated or monitored in CT quality assurance programs. The purpose of this study was to develop/evaluate a new AEC testing platform for the clinical physics program at our institution, and charac ... Full text Link to item Cite

SU-E-I-94: Automated Image Quality Assessment of Radiographic Systems Using An Anthropomorphic Phantom.

Conference Med Phys · June 2014 PURPOSE: In a large, academic medical center, consistent radiographic imaging performance is difficult to routinely monitor and maintain, especially for a fleet consisting of multiple vendors, models, software versions, and numerous imaging protocols. Thus ... Full text Link to item Cite

PET lesion quantitation noise estimates from sub-scan images

Conference JOURNAL OF NUCLEAR MEDICINE · May 1, 2014 Link to item Cite

Prospective optimization of CT under tube current modulation: II. image quality

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 Despite the significant clinical benefits of computed tomography (CT) in providing diagnostic information for a broad range of diseases, concerns have been raised regarding the potential cancer risk induced by CT radiation exposure. In that regard, optimiz ... Full text Cite

A refined methodology for modeling volume quantification performance in CT

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 The utility of CT lung nodule volume quantification technique depends on the precision of the quantification. To enable the evaluation of quantification precision, we previously developed a mathematical model that related precision to image resolution and ... Full text Cite

PET lesion quantitation noise estimates from sub-scan images

Journal Article Society of Nuclear Medicine Annual Meeting Abstracts · 2014 Cite

A methodology for image quality evaluation of advanced CT systems.

Journal Article Med Phys · March 2013 PURPOSE: This work involved the development of a phantom-based method to quantify the performance of tube current modulation and iterative reconstruction in modern computed tomography (CT) systems. The quantification included resolution, HU accuracy, noise ... Full text Link to item Cite

Sodium fluoride PET/CT of metastatic disease burden: Preliminary results of reproducibility measurements

Journal Article Society of Nuclear Medicine Annual Meeting Abstracts · 2013 Cite

Phantom and simulation study to determine image noise levels for a CT-based simulation platform of NaF PET uptake

Journal Article Society of Nuclear Medicine Annual Meeting Abstracts · 2013 Cite

TOF-PET Small-Lesion Image Quality Measured Over a Range of Phantom Sizes

Journal Article Nuclear Science, IEEE Transactions on · 2013 Cite

Investigation of four phantoms for PET normalization

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2012 Normalization in Positron Emission Tomography (PET) is essential to correct for sensitivity variation across detector elements and produce uniform images. Currently, the standard normalization protocol for General Electric (GE) systems requires a 20 minute ... Full text Cite

Target localization using scanner-acquired SPECT data.

Journal Article J Appl Clin Med Phys · May 10, 2012 Target localization using single photon emission computed tomography (SPECT) and planar imaging is being investigated for guiding radiation therapy delivery. Previous studies on SPECT-based localization have used computer-simulated or hybrid images with si ... Full text Open Access Link to item Cite

Target localization using scanner-acquired SPECT data

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2012 Target localization using single photon emission computed tomography (SPECT) and planar imaging is being investigated for guiding radiation therapy delivery. Previous studies on SPECT-based localization have used computer-simulated or hybrid images with si ... Full text Cite

Variable-time positron emission tomography leg protocol to equalize noise for positron emission tomography/computed tomography acquisitions.

Journal Article Nucl Med Commun · September 2011 OBJECTIVES: Positron emission tomography protocols conventionally use a constant scan time per bed position (BP). It may be optimal to spend more time scanning some body sections, particularly the more attenuating sections. The relatively consistent taperi ... Full text Link to item Cite

Development of a fillable, tapered PET/CT phantom

Journal Article Nuclear Science, IEEE Transactions on · 2011 Cite

A systematic review of the factors affecting accuracy of SUV measurements.

Journal Article AJR Am J Roentgenol · August 2010 OBJECTIVE: There is growing interest in using PET/CT for evaluating early response to therapy in cancer treatment. Although widely available and convenient to use, standardized uptake value (SUV) measurements can be influenced by a variety of biologic and ... Full text Link to item Cite

Impact of Image Reconstruction Parameters on Standard Uptake Value in FDG-PET

Conference AMERICAN JOURNAL OF ROENTGENOLOGY · May 1, 2010 Link to item Cite

A phantom study of regularized image reconstruction in PET

Journal Article Nuclear Science Symposium Conference Record (NSS/MIC), 2010 IEEE · 2010 Cite

Attenuation artifacts and time-of-flight PET

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2009 Attenuation artifacts in PET are seen when attenuation correction (AC) is not performed and when AC is performed but is based on an incorrect attenuation map. PET attenuation artifacts are generally more profound than the straightforward differences in pho ... Full text Cite

Comparing small lesion PET image quality with count statistics over a range of body sizes

Journal Article Society of Nuclear Medicine Annual Meeting Abstracts · 2009 Cite

Image quality evaluation on a new time-of-flight PET

Journal Article Society of Nuclear Medicine Annual Meeting Abstracts · 2009 Cite

TOF-PET small-lesion image quality measured over a range of phantom sizes

Journal Article Nuclear Science Symposium Conference Record (NSS/MIC), 2009 IEEE · 2009 Cite

Development of a fillable, tapered PET/CT phantom

Conference 2008 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (2008 NSS/MIC), VOLS 1-9 · January 1, 2009 Link to item Cite

Development of a fillable, tapered PET/CT phantom

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2008 PET system performance and image quality are degraded as body size increases; as size increases so do scatter fractions, random fractions, and attenuation. Based on simulated and acquired data, a fillable, tapering phantom is being developed to measure PET ... Full text Cite

Multisphere phantom and analysis algorithm for PET image quality assessment.

Journal Article Phys Med Biol · June 21, 2008 PET image quality measurements of lesion detectability frequently use a small, radioactive sphere in a larger phantom. The typical analysis of a small single sphere in background has several shortcomings as a measure for detectability and quantitation: the ... Full text Link to item Cite

Limiting iterations vs. post smoothing for noise control in PET

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2007 We have performed physical phantom and simulation study with PET to compare the effects of limiting iterations and post-smoothing. The phantom was designed to mimic small hot lesions typical in FDG PET. The phantom was a body-sized 25 L phantom. Eight 1 cm ... Full text Cite

Development of a phantom to simulate a wide range of body sizes

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2007 X-ray image quality is highly dependent on object size. Diagnostic image quality can be maintained while controlling dose to a patient with tube current modulation schemes. For PET attenuation correction, much lower requirements are placed on CT image qual ... Full text Cite

Performance of random event correction methods in iterative image reconstruction

Journal Article Society of Nuclear Medicine Annual Meeting Abstracts · 2007 Cite

Development of a PET protocol to equalize noise for PET/CT leg acquisitions

Journal Article Nuclear Science Symposium Conference Record, 2007. NSS’07. IEEE · 2007 Cite

Image quality vs. NEC in 2D and 3D PET

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2005 To investigate the relationship between NEC and image quality in 2D and 3D PET, while simultaneously optimizing 3D low energy threshold (LET), we have performed a series of phantom measurements. The phantom consisted of 46 1 cm fillable hollow spheres on a ... Full text Cite