Overview
Current Appointments & Affiliations
James B. Duke Distinguished Professor of Biochemistry
·
1992 - Present
Biochemistry,
Basic Science Departments
Professor of Biochemistry
·
1991 - Present
Biochemistry,
Basic Science Departments
Recent Publications
Cis-nonProline peptides: Genuine occurrences and their functional roles.
Journal Article Protein Sci · June 2025 While cis peptides preceding proline can occur about 5% of the time, cis peptides preceding any other residue ("cis-nonPro" peptides) are an extremely rare feature in protein structures, of considerable importance for two opposite reasons. On one hand, the ... Full text Link to item CiteRNAprecis: Prediction of full-detail RNA conformation from the experimentally best-observed sparse parameters.
Preprint · March 5, 2025 Full text Link to item CiteOutcomes of the EMDataResource cryo-EM Ligand Modeling Challenge.
Journal Article Nat Methods · July 2024 The EMDataResource Ligand Model Challenge aimed to assess the reliability and reproducibility of modeling ligands bound to protein and protein-nucleic acid complexes in cryogenic electron microscopy (cryo-EM) maps determined at near-atomic (1.9-2.5 Å) reso ... Full text Link to item CiteRecent Grants
PHENIX: New methods for automation in macromolecular crystallography
ResearchPrincipal Investigator · Awarded by Ernest Orlando Lawrence Berkeley National Laboratory · 2006 - 2023Extending MolProbity Diagnosis & Healing Methods to Empower Better CryoEM & Xray Models at 2.5-4A Resolution, plus Versioned, Redeposited "GEMS" for Important Individual Structures
ResearchInvestigator · Awarded by National Institutes of Health · 2019 - 2023Bioinformatics and Computational Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2021View All Grants
Recent Artistic Works
Ribbon drawing of triose phosphate isomerase 3D protein structure
Drawing January 1, 1981 on Wikimedia Commons
View All Artistic Works
Education, Training & Certifications
Harvard University ·
1966
M.A.