Overview
Current Appointments & Affiliations
James B. Duke Distinguished Professor of Biochemistry
·
1992 - Present
Biochemistry,
Basic Science Departments
Professor of Biochemistry
·
1991 - Present
Biochemistry,
Basic Science Departments
Recent Publications
New targets and procedures for validating the valence geometry of nucleic acid structures.
Journal Article Nucleic Acids Res · January 5, 2026 A Working Group consisting of the co-authors of this paper was established in 2020 to re-evaluate the standard valence geometry used for the validation of nucleic acid structure models in the Protein Data Bank (PDB). This Working Group re-examined the depe ... Full text Link to item CiteCategorizing prediction modes within low-pLDDT regions of AlphaFold2 structures: near-predictive, pseudostructure and barbed wire.
Journal Article Acta Crystallogr D Struct Biol · October 1, 2025 AlphaFold2 protein structure predictions are widely available for structural biology uses. These predictions, especially for eukaryotic proteins, frequently contain extensive regions predicted below the pLDDT = 70 level, the rule-of-thumb cutoff for high c ... Full text Link to item CiteCategorizing prediction modes within low-pLDDT regions of AlphaFold2 structures.
Preprint · June 7, 2025 Full text Link to item CiteRecent Grants
Reimplementing the MolProbity website to be maintained by Phenix & modifying code for Phenix cctbx
ResearchPrincipal Investigator · Awarded by Ernest Orlando Lawrence Berkeley National Laboratory · 2025 - 2026PHENIX: New methods for automation in macromolecular crystallography
ResearchPrincipal Investigator · Awarded by Ernest Orlando Lawrence Berkeley National Laboratory · 2006 - 2023Extending MolProbity Diagnosis & Healing Methods to Empower Better CryoEM & Xray Models at 2.5-4A Resolution, plus Versioned, Redeposited "GEMS" for Important Individual Structures
ResearchInvestigator · Awarded by National Institutes of Health · 2019 - 2023View All Grants
Recent Artistic Works
Ribbon drawing of triose phosphate isomerase 3D protein structure
Drawing January 1, 1981 on Wikimedia Commons
View All Artistic Works
Education, Training & Certifications
Harvard University ·
1966
M.A.