Overview
Current Appointments & Affiliations
James B. Duke Distinguished Professor of Biochemistry
·
1992 - Present
Biochemistry,
Basic Science Departments
Professor of Biochemistry
·
1991 - Present
Biochemistry,
Basic Science Departments
Recent Publications
Categorizing prediction modes within low-pLDDT regions of AlphaFold2 structures: near-predictive, pseudostructure and barbed wire.
Journal Article Acta Crystallogr D Struct Biol · October 1, 2025 AlphaFold2 protein structure predictions are widely available for structural biology uses. These predictions, especially for eukaryotic proteins, frequently contain extensive regions predicted below the pLDDT = 70 level, the rule-of-thumb cutoff for high c ... Full text Link to item CiteCategorizing prediction modes within low-pLDDT regions of AlphaFold2 structures.
Preprint · June 7, 2025 Full text Link to item CiteCis-nonProline peptides: Genuine occurrences and their functional roles.
Journal Article Protein Sci · June 2025 While cis peptides preceding proline can occur about 5% of the time, cis peptides preceding any other residue ("cis-nonPro" peptides) are an extremely rare feature in protein structures, of considerable importance for two opposite reasons. On one hand, the ... Full text Link to item CiteRecent Grants
Reimplementing the MolProbity website to be maintained by Phenix & modifying code for Phenix cctbx
ResearchPrincipal Investigator · Awarded by Ernest Orlando Lawrence Berkeley National Laboratory · 2025 - 2026PHENIX: New methods for automation in macromolecular crystallography
ResearchPrincipal Investigator · Awarded by Ernest Orlando Lawrence Berkeley National Laboratory · 2006 - 2023Extending MolProbity Diagnosis & Healing Methods to Empower Better CryoEM & Xray Models at 2.5-4A Resolution, plus Versioned, Redeposited "GEMS" for Important Individual Structures
ResearchInvestigator · Awarded by National Institutes of Health · 2019 - 2023View All Grants
Recent Artistic Works
Ribbon drawing of triose phosphate isomerase 3D protein structure
Drawing January 1, 1981 on Wikimedia Commons
View All Artistic Works
Education, Training & Certifications
Harvard University ·
1966
M.A.