Judith Mae Kramer | Scholars@Duke

Judith Mae Kramer
Professor Emeritus of Medicine

· Studying methods to facilitate the uptake of evidence-based treatment recommendations.
· Optimizing the use of drugs, devices, and biological products in clinical practice.
· Studying methods of risk management for therapeutic products

Current Appointments & Affiliations

Professor Emeritus of Medicine, Medicine, General Internal Medicine, Medicine 2014
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 1997

Contact Information

2400 Pratt St, Durham, NC 27705
Box 3850 Med Ctr, Durham, NC 27710
judith.kramer@duke.edu

Background
Education, Training, & Certifications
- M.D., University of North Carolina - Chapel Hill 1977
- M.S., University of North Carolina - Chapel Hill 1972
- B.S., University of North Carolina - Chapel Hill 1970
Duke Appointment History
- Professor of Medicine, Medicine, General Internal Medicine, Medicine 2012 - 2014
- Associate Professor of Medicine, Medicine, General Internal Medicine, Medicine 2011 - 2012
- Associate Professor of Medicine, Medicine, General Internal Medicine, Medicine 2006 - 2011
- Assistant Clinical Professor of Medicine, Medicine, General Internal Medicine, Medicine 1998 - 2006
- Instructor, Temporary in the Department of Medicine, Medicine, General Internal Medicine, Medicine 1997 - 1998
Recognition
In the News
- MAY 27, 2016 The Washington Post
  
  FDA approves new way to treat opioid addiction -- under the skin
- JAN 14, 2016 USA Today
  
  Dr. Judith Kramer comments: Panel recommends FDA approve implant to treat opiate addiction
Research
Selected Grants
- CTTI U19 awarded by Food and Drug Administration 2009 - 2015
- Duke Cardiovascular CERTs awarded by Agency for Healthcare Research and Quality 2007 - 2012
- Barriers to Optimal Cardiovascular Medication Use in Diabetes and Renal Disease awarded by National Institutes of Health 2006 - 2011
- DCRI Research Center for CERTs awarded by Agency for Healthcare Research and Quality 1999 - 2008
- CBER Study of Adverse Effects in use of TNF Inhibitors awarded by Food and Drug Administration 2004 - 2007
- Managing the Risks of Therapeutic Products awarded by Agency for Healthcare Research and Quality 2003 - 2004
- Managing the Risks of Therapeutic Products, January 12-14, 2003. awarded by Agency for Healthcare Research and Quality 2002 - 2003
- Coordinating Center for CERTs awarded by National Institutes of Health 2002 - 2003
- DCRI CERT for Cardiovascular Therapies awarded by National Institutes of Health 1999 - 2002
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Sethi, Sundeep S., Judith M. Kramer, Suzanne Gagnon, Greg Nadzan, and José M. Vega. “Industry Practices for Expedited Reporting to Investigators Conducting Research Under an IND.” Ther Innov Regul Sci 48, no. 6 (November 2014): 741–48. https://doi.org/10.1177/2168479014532260.
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  - Kramer, Judith M., David Vock, Howard E. Greenberg, Cheri Janning, Lynda Szczech, Miklos Salgo, Suzanne Gagnon, and Susan Ellenberg. “Investigators' Experience With Expedited Safety Reports Prior to the FDA's Final IND Safety Reporting Rule.” Ther Innov Regul Sci 48, no. 4 (July 2014): 413–19. https://doi.org/10.1177/2168479013520160.
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  - Archdeacon, Patrick, Cheryl Grandinetti, José M. Vega, David Balderson, and Judith M. Kramer. “Optimizing Expedited Safety Reporting for Drugs and Biologics Subject to an Investigational New Drug Application.” Ther Innov Regul Sci 48, no. 2 (March 2014): 200–207. https://doi.org/10.1177/2168479013509382.
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  - Alexander, Karen P., David F. Kong, Aijing Z. Starr, Judith Kramer, Karen Chiswell, Asba Tasneem, and Robert M. Califf. “Portfolio of clinical research in adult cardiovascular disease as reflected in ClinicalTrials.gov.” J Am Heart Assoc 2, no. 5 (September 26, 2013): e000009. https://doi.org/10.1161/JAHA.113.000009.
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  - Check, Devon K., Kevin P. Weinfurt, Carrie B. Dombeck, Judith M. Kramer, and Kathryn E. Flynn. “Use of central institutional review boards for multicenter clinical trials in the United States: a review of the literature.” Clin Trials 10, no. 4 (August 2013): 560–67. https://doi.org/10.1177/1740774513484393.
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  - Flynn, Kathryn E., Judith M. Kramer, Carrie B. Dombeck, and Kevin P. Weinfurt. “Participants' perspectives on safety monitoring in clinical trials.” Clin Trials 10, no. 4 (August 2013): 552–59. https://doi.org/10.1177/1740774513484394.
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  - Flynn, Kathryn E., Cynthia L. Hahn, Judith M. Kramer, Devon K. Check, Carrie B. Dombeck, Soo Bang, Jane Perlmutter, Felix A. Khin-Maung-Gyi, and Kevin P. Weinfurt. “Using central IRBs for multicenter clinical trials in the United States.” Plos One 8, no. 1 (2013): e54999. https://doi.org/10.1371/journal.pone.0054999.
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  - Velentgas, Priscilla, Anthony A. Amato, Rhonda L. Bohn, K Arnold Chan, Thomas Cochrane, Donnie P. Funch, Inna Dashevsky, et al. “Risk of Guillain-Barré syndrome after meningococcal conjugate vaccination.” Pharmacoepidemiol Drug Saf 21, no. 12 (December 2012): 1350–58. https://doi.org/10.1002/pds.3321.
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  - Landray, M. J., C. Grandinetti, J. M. Kramer, B. W. Morrison, L. Ball, and R. E. Sherman. “Clinical Trials: Rethinking How We Ensure Quality.” Drug Information Journal 46, no. 6 (November 1, 2012): 657–60. https://doi.org/10.1177/0092861512464372.
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  - Califf, Robert M., Deborah A. Zarin, Judith M. Kramer, Rachel E. Sherman, Laura H. Aberle, and Asba Tasneem. “Characteristics of clinical trials registered in ClinicalTrials.gov, 2007-2010.” Jama 307, no. 17 (May 2, 2012): 1838–47. https://doi.org/10.1001/jama.2012.3424.
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  - Calvert, Sara Bristol, Judith M. Kramer, Kevin J. Anstrom, Lisa A. Kaltenbach, Judith A. Stafford, and Nancy M. Allen LaPointe. “Patient-focused intervention to improve long-term adherence to evidence-based medications: a randomized trial.” Am Heart J 163, no. 4 (April 2012): 657-65.e1. https://doi.org/10.1016/j.ahj.2012.01.019.
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  - Kramer, J. M., P. B. Smith, and R. M. Califf. “Impediments to clinical research in the United States.” Clin Pharmacol Ther 91, no. 3 (March 2012): 535–41. https://doi.org/10.1038/clpt.2011.341.
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  - Morrison, Briggs W., Chrissy J. Cochran, Jennifer Giangrande White, Joan Harley, Cynthia F. Kleppinger, An Liu, Jules T. Mitchel, et al. “Monitoring the quality of conduct of clinical trials: a survey of current practices.” Clin Trials 8, no. 3 (June 2011): 342–49. https://doi.org/10.1177/1740774511402703.
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  - Luce, Bryan R., Judith M. Kramer, Steven N. Goodman, Jason T. Connor, Sean Tunis, Danielle Whicher, and J Sanford Schwartz. “Rethinking randomized clinical trials for comparative effectiveness research: the need for transformational change.” Ann Intern Med 151, no. 3 (August 4, 2009): 206–9. https://doi.org/10.7326/0003-4819-151-3-200908040-00126.
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  - Kramer, J. M. “The author replies.” New England Journal of Medicine 361, no. 2 (July 9, 2009): 209. https://doi.org/10.1056/NEJMc096182.
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  - Kramer, Judith M. “Long-Acting Beta-Agonists in Asthma REPLY.” New England Journal of Medicine 361, no. 2 (July 9, 2009): 209–209.
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  - Kramer, J. M., L. H. Curtis, C. S. Dupree, A. F. Hernandez, M. Massing, and K. J. Anstrom. “Eligibility criteria for β-blockade might have to be taken into account - Reply.” Archives of Internal Medicine 169, no. 11 (June 8, 2009): 1078.
  - Allen LaPointe, Nancy M., Yi Zhou, Judith A. Stafford, Adrian F. Hernandez, Judith M. Kramer, and Kevin J. Anstrom. “Association between mortality and persistent use of beta blockers and angiotensin-converting enzyme inhibitors in patients with left ventricular systolic dysfunction and coronary artery disease.” Am J Cardiol 103, no. 11 (June 1, 2009): 1518–24. https://doi.org/10.1016/j.amjcard.2009.01.363.
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  - Kramer, Judith M. “Balancing the benefits and risks of inhaled long-acting beta-agonists--the influence of values.” N Engl J Med 360, no. 16 (April 16, 2009): 1592–95. https://doi.org/10.1056/NEJMp0810561.
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  - Tricoci, Pierluigi, Joseph M. Allen, Judith M. Kramer, Robert M. Califf, and Sidney C. Smith. “Scientific evidence underlying the ACC/AHA clinical practice guidelines.” Jama 301, no. 8 (February 25, 2009): 831–41. https://doi.org/10.1001/jama.2009.205.
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  - Curtis, Lesley H., Melissa A. Greiner, Bradley G. Hammill, Judith M. Kramer, David J. Whellan, Kevin A. Schulman, and Adrian F. Hernandez. “Early and long-term outcomes of heart failure in elderly persons, 2001-2005.” Arch Intern Med 168, no. 22 (December 8, 2008): 2481–88. https://doi.org/10.1001/archinte.168.22.2481.
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  - Kramer, Judith M., Lesley H. Curtis, Carla S. Dupree, David Pelter, Adrian Hernandez, Mark Massing, and Kevin J. Anstrom. “Comparative effectiveness of beta-blockers in elderly patients with heart failure.” Arch Intern Med 168, no. 22 (December 8, 2008): 2422–28. https://doi.org/10.1001/archinternmed.2008.511.
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  - Velentgas, Priscilla, Rhonda L. Bohn, Jeffrey S. Brown, K Arnold Chan, Patricia Gladowski, Crystal N. Holick, Judith M. Kramer, et al. “A distributed research network model for post-marketing safety studies: the Meningococcal Vaccine Study.” Pharmacoepidemiol Drug Saf 17, no. 12 (December 2008): 1226–34. https://doi.org/10.1002/pds.1675.
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  - Anstrom, Kevin J., David F. Kong, Linda K. Shaw, Robert M. Califf, Judith M. Kramer, Eric D. Peterson, Sunil V. Rao, et al. “Long-term clinical outcomes following coronary stenting.” Arch Intern Med 168, no. 15 (August 11, 2008): 1647–55. https://doi.org/10.1001/archinte.168.15.1647.
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  - Califf, Robert M., and Judith M. Kramer. “The balance of benefit and safety of rosiglitazone: important lessons for our system of drug development and postmarketing assessment.” Pharmacoepidemiol Drug Saf 17, no. 8 (August 2008): 782–86. https://doi.org/10.1002/pds.1617.
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  - Rao, Sunil V., Robert M. Califf, Judith M. Kramer, Eric D. Peterson, Thomas P. Gross, Carl J. Pepine, David O. Williams, et al. “Postmarket evaluation of breakthrough technologies.” Am Heart J 156, no. 2 (August 2008): 201–8. https://doi.org/10.1016/j.ahj.2008.01.036.
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  - Smith, David H., Judith M. Kramer, Nancy Perrin, Richard Platt, Douglas W. Roblin, Kimberly Lane, Michael Goodman, Winnie W. Nelson, Xiuhai Yang, and Stephen B. Soumerai. “A randomized trial of direct-to-patient communication to enhance adherence to beta-blocker therapy following myocardial infarction.” Arch Intern Med 168, no. 5 (March 10, 2008): 477–83. https://doi.org/10.1001/archinternmed.2007.132.
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  - Curtis, J. R., J. M. Kramer, C. Martin, K. G. Saag, N. Patkar, D. Shatin, M. Burgess, A. Xie, and M. M. Braun. “Heart failure among younger rheumatoid arthritis and Crohn's patients exposed to TNF-alpha antagonists.” Rheumatology (Oxford) 46, no. 11 (November 2007): 1688–93. https://doi.org/10.1093/rheumatology/kem212.
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  - Curtis, Lesley H., Bradley G. Hammill, Eric L. Eisenstein, Judith M. Kramer, and Kevin J. Anstrom. “Using inverse probability-weighted estimators in comparative effectiveness analyses with observational databases.” Med Care 45, no. 10 Supl 2 (October 2007): S103–7. https://doi.org/10.1097/MLR.0b013e31806518ac.
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  - Curtis, J. R., C. Martin, K. G. Saag, N. M. Patkar, J. Kramer, D. Shatin, J. Allison, and M. M. Braun. “Confirmation of administrative claims-identified opportunistic infections and other serious potential adverse events associated with tumor necrosis factor alpha antagonists and disease-modifying antirheumatic drugs.” Arthritis Rheum 57, no. 2 (March 15, 2007): 343–46. https://doi.org/10.1002/art.22544.
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  - Eisenstein, Eric L., Kevin J. Anstrom, David F. Kong, Linda K. Shaw, Robert H. Tuttle, Daniel B. Mark, Judith M. Kramer, et al. “Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation.” Jama 297, no. 2 (January 10, 2007): 159–68. https://doi.org/10.1001/jama.297.2.joc60179.
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  - Curtis, L. H., B. G. Hammill, E. L. Eisenstein, J. M. Kramer, and K. J. Anstrom. “Using inverse probability-weighted estimators in comparative effectiveness analyses with observational databases.” Medical Care 45, no. 10 SUPPL. 2 (January 1, 2007). https://doi.org/10.1097/mlr.0b013e31806518ac.
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  - Kramer, Judith M., Bradley Hammill, Kevin J. Anstrom, Donald Fetterolf, Richard Snyder, John P. Charde, Barbara S. Hoffman, Nancy Allen LaPointe, and Eric Peterson. “National evaluation of adherence to beta-blocker therapy for 1 year after acute myocardial infarction in patients with commercial health insurance.” Am Heart J 152, no. 3 (September 2006): 454.e1-454.e8. https://doi.org/10.1016/j.ahj.2006.02.030.
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  - Newby, L. K., N. M. Allen-LaPointe, A. Y. Chen, J. M. Kramer, B. G. Hammill, E. R. DeLong, L. H. Muhlbaier, and R. M. Califf. “Response to letter regarding article, "Long-term adherence to evidence-based secondary prevention therapies in coronary artery disease" [2].” Circulation 114, no. 6 (August 1, 2006). https://doi.org/10.1161/CIRCULATIONAHA.106.627521.
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  - Allen LaPointe, Nancy M., Lesley H. Curtis, K Arnold Chan, Judith M. Kramer, Jennifer Elston Lafata, Jerry H. Gurwitz, Marsha A. Raebel, and Richard Platt. “Frequency of high-risk use of QT-prolonging medications.” Pharmacoepidemiol Drug Saf 15, no. 6 (June 2006): 361–68. https://doi.org/10.1002/pds.1155.
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  - Allen LaPointe, N. M., E. R. DeLong, A. Chen, B. G. Hammill, L. H. Muhlbaier, R. M. Califf, and J. M. Kramer. “Multifaceted intervention to promote β-blocker use in heart failure.” American Heart Journal 151, no. 5 (May 1, 2006): 999–1005. https://doi.org/10.1016/j.ahj.2005.10.011.
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  - LaPointe, Nancy M Allen, Elizabeth R. DeLong, Anita Chen, Bradley G. Hammill, Lawrence H. Muhlbaier, Robert M. Califf, and Judith M. Kramer. “Multifaceted intervention to promote beta-blocker use in heart failure.” Am Heart J 151, no. 5 (May 2006): 992–98. https://doi.org/10.1016/j.ahj.2005.06.038.
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  - Ridley, David B., Judith M. Kramer, Hugh H. Tilson, Henry G. Grabowski, and Kevin A. Schulman. “Spending on postapproval drug safety.” Health Aff (Millwood) 25, no. 2 (March 2006): 429–36. https://doi.org/10.1377/hlthaff.25.2.429.
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  - Newby, L Kristin, Nancy M Allen LaPointe, Anita Y. Chen, Judith M. Kramer, Bradley G. Hammill, Elizabeth R. DeLong, Lawrence H. Muhlbaier, and Robert M. Califf. “Long-term adherence to evidence-based secondary prevention therapies in coronary artery disease.” Circulation 113, no. 2 (January 17, 2006): 203–12. https://doi.org/10.1161/CIRCULATIONAHA.105.505636.
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  - LaPointe, N. M. A., and J. M. Kramer. “Authors' reply.” American Heart Journal 152, no. 4 (2006): e45. https://doi.org/10.1016/j.ahj.2006.07.006.
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  - Ridley, D. B., and J. M. Kramer. “Postapproval drug safety: The authors respond [8].” Health Affairs 25, no. 4 (January 1, 2006): 1187–88. https://doi.org/10.1377/hlthaff.25.4.1184-a.
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  - Ridley, David B., and Judith M. Kramer. “Postapproval drug safety: The authors respond.” Health Affairs 25, no. 4 (2006): 1187–88. https://doi.org/10.1377/hlthaff.25.4.1187.
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  - Kramer, Judith M. “Managing the risks of therapeutic products: proceedings of a workshop.” Pharmacoepidemiol Drug Saf 14, no. 9 (September 2005): 619–28. https://doi.org/10.1002/pds.1060.
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  - Al-Khatib, Sana M., Nancy M. Allen LaPointe, Judith M. Kramer, Anita Y. Chen, Bradley G. Hammill, Liz Delong, and Robert M. Califf. “A survey of health care practitioners' knowledge of the QT interval.” J Gen Intern Med 20, no. 5 (May 2005): 392–96. https://doi.org/10.1111/j.1525-1497.2005.0101.x.
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  - O’Shea, J Conor, Judith M. Kramer, Robert M. Califf, and Eric D. Peterson. “Part I: Identifying holes in the safety net.” Am Heart J 147, no. 6 (June 2004): 977–84. https://doi.org/10.1016/j.ahj.2004.03.001.
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  - Peterson, Eric D., John W. Hirshfeld, T Bruce Ferguson, Judith M. Kramer, Robert M. Califf, and Larry G. Kessler. “Part II: Sealing holes in the safety net.” Am Heart J 147, no. 6 (June 2004): 985–90. https://doi.org/10.1016/j.ahj.2004.03.002.
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  - Kramer, Judith M., L Kristin Newby, Wei Ching Chang, R John Simes, Frans Van de Werf, Christopher B. Granger, Kerry L. Lee, et al. “International variation in the use of evidence-based medicines for acute coronary syndromes.” Eur Heart J 24, no. 23 (December 2003): 2133–41. https://doi.org/10.1016/j.ehj.2003.09.018.
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  - Newby, L Kristin, Manjushri V. Bhapkar, Harvey D. White, David J. Moliterno, Nancy M Allen LaPointe, David E. Kandzari, Freek W. A. Verheugt, et al. “Aspirin use post-acute coronary syndromes: intolerance, bleeding and discontinuation.” J Thromb Thrombolysis 16, no. 3 (December 2003): 119–28. https://doi.org/10.1023/B:THRO.0000024050.78728.35.
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  - Allen LaPointe, Nancy M., Anita Chen, Bradley Hammill, Elizabeth DeLong, Judith M. Kramer, and Robert M. Califf. “Evaluation of the dofetilide risk-management program.” Am Heart J 146, no. 5 (November 2003): 894–901. https://doi.org/10.1016/S0002-8703(03)00409-5.
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  - LaPointe, Nancy M Allen, Carol A. Pamer, and Judith M. Kramer. “New antiarrhythmic agents for atrial fibrillation and atrial flutter: United States drug market response as an indicator of acceptance.” Pharmacotherapy 23, no. 10 (October 2003): 1316–21. https://doi.org/10.1592/phco.23.12.1316.32703.
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  - Krantz, Mori J., Bridget A. Martell, Julia H. Arnsten, and Marc N. Gourevitch. “Medications that prolong the QT interval.” Jama 290, no. 8 (August 27, 2003): 1025. https://doi.org/10.1001/jama.290.8.1025-a.
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  - Kwon, Hyon J., Timothy R. Coté, Michael S. Cuffe, Judith M. Kramer, and M Miles Braun. “Case reports of heart failure after therapy with a tumor necrosis factor antagonist.” Ann Intern Med 138, no. 10 (May 20, 2003): 807–11. https://doi.org/10.7326/0003-4819-138-10-200305200-00008.
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  - Al-Khatib, Sana M., Nancy M Allen LaPointe, Judith M. Kramer, and Robert M. Califf. “What clinicians should know about the QT interval.” Jama 289, no. 16 (April 23, 2003): 2120–27. https://doi.org/10.1001/jama.289.16.2120.
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  - LaPointe, Nancy M Allen, Sana M. Al-Khatib, Judith M. Kramer, and Robert M. Califf. “Knowledge deficits related to the QT interval could affect patient safety.” Ann Noninvasive Electrocardiol 8, no. 2 (April 2003): 157–60. https://doi.org/10.1046/j.1542-474x.2003.08211.x.
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  - Al-Khatib, Sana M., Nancy M Allen LaPointe, Lesley H. Curtis, Judith M. Kramer, Joslyn Swann, Peter Honig, and Robert M. Califf. “Outpatient prescribing of antiarrhythmic drugs from 1995 to 2000.” Am J Cardiol 91, no. 1 (January 1, 2003): 91–94. https://doi.org/10.1016/s0002-9149(02)03008-4.
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  - Cantor, Warren J., Julie M. Miller, Anne S. Hellkamp, Judith M. Kramer, Eric D. Peterson, Vic Hasselblad, James P. Zidar, L Kristin Newby, and E Magnus Ohman. “Role of target vessel size and body surface area on outcomes after percutaneous coronary interventions in women.” Am Heart J 144, no. 2 (August 2002): 297–302. https://doi.org/10.1067/mhj.2002.123318.
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  - LaPointe, Nancy M Allen, Judith M. Kramer, Kevin P. Weinfurt, and Robert M. Califf. “Practitioner acceptance of the dofetilide risk-management program.” Pharmacotherapy 22, no. 8 (August 2002): 1041–46. https://doi.org/10.1592/phco.22.12.1041.33611.
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  - Shah, Monica R., Vic Hasselblad, Sandra S. Stinnett, Judith M. Kramer, Steven Grossman, Mihai Gheorghiade, Kirkwood F. Adams, Karl Swedberg, Robert M. Califf, and Christopher M. O’Connor. “Dissociation between hemodynamic changes and symptom improvement in patients with advanced congestive heart failure.” Eur J Heart Fail 4, no. 3 (June 2002): 297–304. https://doi.org/10.1016/s1388-9842(01)00202-1.
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  - Allen LaPointe, Nancy M., Judith M. Kramer, Elizabeth R. DeLong, Truls Ostbye, Bradley G. Hammill, Lawrence H. Muhlbaier, Charles B. McCants, Anita Chen, and Robert M. Califf. “Patient-reported frequency of taking aspirin in a population with coronary artery disease.” Am J Cardiol 89, no. 9 (May 1, 2002): 1042–46. https://doi.org/10.1016/s0002-9149(02)02272-5.
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  - Califf, Robert M., Elizabeth R. DeLong, Truls Ostbye, Lawrence H. Muhlbaier, Anita Chen, Nancy Allen LaPointe, Bradley G. Hammill, Charles B. McCants, and Judith M. Kramer. “Underuse of aspirin in a referral population with documented coronary artery disease.” Am J Cardiol 89, no. 6 (March 15, 2002): 653–61. https://doi.org/10.1016/s0002-9149(01)02335-9.
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  - Kramer, J. M., L. A. Bosco, and R. M. Califf. “Centers for Education and Research on Therapeutics (CERTs).” Drug Information Journal 36, no. 3 (2002): 717–23.
  - Peterson, E. D., A. J. Lansky, J. Kramer, K. Anstrom, M. J. Lanzilotta, and M. J. National Cardiovascular Network Clinical Investigators. “Effect of gender on the outcomes of contemporary percutaneous coronary intervention.” Am J Cardiol 88, no. 4 (August 15, 2001): 359–64. https://doi.org/10.1016/s0002-9149(01)01679-4.
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  - Califf, R. M., and J. M. Kramer. “What have we learned from the calcium channel blocker controversy?” Circulation 97, no. 16 (April 28, 1998): 1529–31. https://doi.org/10.1161/01.cir.97.16.1529.
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  - Kase, C. S., M. S. Pessin, J. A. Zivin, G. J. del Zoppo, A. J. Furlan, J. W. Buckley, R. G. Snipes, and J. K. LittleJohn. “Intracranial hemorrhage after coronary thrombolysis with tissue plasminogen activator.” Am J Med 92, no. 4 (April 1992): 384–90. https://doi.org/10.1016/0002-9343(92)90268-g.
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  - LittleJohn, J. K. “Package insert: view of a rural town practitioner.” Drug Inf J 21, no. 1 (1987): 63–65. https://doi.org/10.1177/009286158702100111.
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- Conference Papers
  - Curtis, J. R., K. G. Saag, C. Martin, N. Patkar, D. Shatin, J. M. Kramer, and M. M. Braun. “Validation of claims-identified serious adverse events in rheumatoid arthritis and Crohn's disease patients.” In Arthritis and Rheumatism, 52:4085–4085. WILEY-LISS, 2005.
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  - Kramer, J. M., A. Y. Chen, B. G. Hammill, E. R. DeLong, N. A. LaPointe, L. H. Muhlbaier, C. B. McCants, and R. M. Califf. “Time trends and factors associated with outpatient beta-blocker use in patients with heart failure or left ventricular dysfunction.” In Circulation, 109:E265–E265. LIPPINCOTT WILLIAMS & WILKINS, 2004.
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  - Kramer, J. M., D. Fetterolf, J. P. Charde, R. Snyder, B. Hammill, E. DeLong, B. S. Hoffman, R. L. Arrington, N. A. LaPointe, and E. D. Peterson. “National evaluation of adherence to beta-blocker therapy for one year after acute myocardial infarction in patients with commercial health insurance.” In Circulation, 109:E289–E289. LIPPINCOTT WILLIAMS & WILKINS, 2004.
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  - Newby, L. K., N. M. A. LaPointe, J. M. Kramer, A. Chen, B. G. Hammil, L. H. Muhlbaier, E. R. DeLong, and R. M. Califf. “Long-term adherence to evidence-based secondary prevention in coronary artery disease.” In Circulation, 109:E231–E231. LIPPINCOTT WILLIAMS & WILKINS, 2004.
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  - LaPointe, N. M. A., J. M. Kramer, E. R. DeLong, L. H. Muhlbaier, A. Chen, B. G. Hammill, C. B. McCants, and R. M. Califf. “A randomized controlled trial of Internet-based academic detailing in heart failure: Failure to engage or change.” In Journal of the American College of Cardiology, 43:424A-424A. ELSEVIER SCIENCE INC, 2004.
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