Julia Antoinette Messina

Julia Antoinette Messina
Assistant Professor of Medicine

I am a Transplant Infectious Diseases Physician who specializes in the care of immunocompromised patients including solid organ and bone marrow transplant recipients and patients with HIV. My research interest is in the role of the gut microbiome in the propagation of invasive bacterial infections in patients with hematologic malignancies.

Current Appointments & Affiliations

Assistant Professor of Medicine, Medicine, Infectious Diseases, Medicine 2019

Contact Information

Hanes House Room 150, Box DUMC 102359, Durham, NC 27710
julia.messina@duke.edu (919) 684-2660
Dukehealth.org Profile

Background
Education, Training, & Certifications
- Infectious Disease Certification, American Board of Internal Medicine 2018
- Infectious Diseases Fellowship, Medicine, Duke University School of Medicine 2013 - 2018
- M.H.S., Duke University School of Medicine 2018
- Internal Medicine Residency, Virginia Commonwealth University School of Medicine 2010 - 2013
- M.D., Virginia Commonwealth University School of Medicine 2010
Medical Licensure
- 2018-01198. North Carolina. 2019
Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2018 - 2019
Recognition
In the News
- NOV 8, 2014 Duke Fuqua
  
  Students Innovate on Ebola
Expertise
Subject Headings
Global Scholarship
- Research
  - United States of America (Country)
Research
Fellowships, Supported Research, & Other Grants
- T32 Transplant Infectious Diseases Training Program awarded by NIH/NIAID 2015 - 2018
- Antibacterial Resistance Leadership Group awarded by NIH/NIAID 2014 - 2015
- Duke Clinical Research Institute Fellowship awarded by Duke University 2014 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Messina, Julia A., Cameron R. Wolfe, Marion Hemmersbach-Miller, Carmelo Milano, Jamie L. Todd, John Reynolds, Barbara D. Alexander, Wiley A. Schell, Christina A. Cuomo, and John R. Perfect. “Genomic characterization of recurrent mold infections in thoracic transplant recipients..” Transplant Infectious Disease : An Official Journal of the Transplantation Society 20, no. 5 (October 2018). https://doi.org/10.1111/tid.12935.
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  - Messina, Julia A., Rohita Sinha, Kimberly Starr, Mehreen Arshad, Barbara D. Alexander, Nelson J. Chao, and Anthony D. Sung. “Clinical and Genomic Characterization of Recurrent Enterococcal Bloodstream Infection in Patients With Acute Leukemia..” Open Forum Infectious Diseases 5, no. 6 (June 2018). https://doi.org/10.1093/ofid/ofy107.
    Full Text Open Access Copy
  - Freischlag, Kyle William, Julia Messina, Brian Ezekian, Michael S. Mulvihill, Andrew Barbas, Carl Berg, Debra Sudan, John Reynolds, Matthew Hartwig, and Stuart Knechtle. “Single-Center Long-Term Analysis of Combined Liver-Lung Transplant Outcomes..” Transplantation Direct 4, no. 5 (May 2018). https://doi.org/10.1097/TXD.0000000000000785.
    Full Text Open Access Copy
  - Hemmersbach-Miller, Marion, Carl L. Berg, Julia A. Messina, and Cameron R. Wolfe. “Transplant Drug Interactions and a Word of Caution for the HIV Provider. A Case Report..” Open Forum Infectious Diseases 5, no. 4 (April 5, 2018). https://doi.org/10.1093/ofid/ofy070.
    Full Text Open Access Copy
  - DeFilipp, Zachariah, Jonathan U. Peled, Shuli Li, Jasmin Mahabamunuge, Zeina Dagher, Ann E. Slingerland, Candice Del Rio, et al. “Third-party fecal microbiota transplantation following allo-HCT reconstitutes microbiome diversity..” Blood Advances 2, no. 7 (April 2018): 745–53. https://doi.org/10.1182/bloodadvances.2018017731.
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  - Pericàs, J. M., J. A. Messina, C. Garcia-de-la-Mària, L. Park, B. K. Sharma-Kuinkel, F. Marco, D. Wray, et al. “Influence of vancomycin minimum inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus left-sided infective endocarditis treated with antistaphylococcal β-lactam antibiotics: a prospective cohort study by the International Collaboration on Endocarditis..” Clinical Microbiology and Infection : The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 23, no. 8 (August 2017): 544–49. https://doi.org/10.1016/j.cmi.2017.01.017.
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  - Jackson, W., C. P. Hornik, J. A. Messina, K. Guglielmo, A. Watwe, G. Delancy, A. Valdez, et al. “In-hospital outcomes of premature infants with severe bronchopulmonary dysplasia..” Journal of Perinatology : Official Journal of the California Perinatal Association 37, no. 7 (July 2017): 853–56. https://doi.org/10.1038/jp.2017.49.
    Full Text Open Access Copy
  - Tie, Guodong, Jinglian Yan, Lyne Khair, Julia A. Messina, April Deng, Joonsoo Kang, Thomas Fazzio, and Louis M. Messina. “Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells..” Cancer Research 77, no. 9 (May 2017): 2351–62. https://doi.org/10.1158/0008-5472.CAN-16-1916.
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  - Parente, V., R. H. Clark, L. Ku, C. Fennell, M. Johnson, E. Morris, A. Romaine, et al. “Risk factors for group B streptococcal disease in neonates of mothers with negative antenatal testing..” J Perinatol 37, no. 2 (February 2017): 157–61. https://doi.org/10.1038/jp.2016.201.
    Full Text Link to Item
  - Messina, Julia A., Eileen K. Maziarz, Andrej Spec, Dimitrios P. Kontoyiannis, and John R. Perfect. “Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib..” Open Forum Infectious Diseases 4, no. 1 (January 2017). https://doi.org/10.1093/ofid/ofw261.
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  - Messina, Julia A., Eric Cober, Sandra S. Richter, Federico Perez, Robert A. Salata, Robert C. Kalayjian, Richard R. Watkins, et al. “Hospital Readmissions in Patients With Carbapenem-Resistant Klebsiella pneumoniae..” Infection Control and Hospital Epidemiology 37, no. 3 (March 2016): 281–88. https://doi.org/10.1017/ice.2015.298.
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  - Qi, Robert, Hwang-Soo Joo, Batu Sharma-Kuinkel, Nicholas R. Berlon, Lawrence Park, Chih-Lung Fu, Julia A. Messina, et al. “Increased in vitro phenol-soluble modulin production is associated with soft tissue infection source in clinical isolates of methicillin-susceptible Staphylococcus aureus..” The Journal of Infection 72, no. 3 (March 2016): 302–8. https://doi.org/10.1016/j.jinf.2015.11.002.
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  - Messina, Julia A., Joshua T. Thaden, Batu K. Sharma-Kuinkel, and Vance G. Fowler. “Impact of Bacterial and Human Genetic Variation on Staphylococcus aureus Infections..” Plos Pathogens 12, no. 1 (January 14, 2016). https://doi.org/10.1371/journal.ppat.1005330.
    Full Text Open Access Copy
  - Thaden, Joshua T., Jessica E. Ericson, Heather Cross, Stephen P. Bergin, Julia A. Messina, Vance G. Fowler, Daniel K. Benjamin, et al. “Survival Benefit of Empirical Therapy for Staphylococcus aureus Bloodstream Infections in Infants..” The Pediatric Infectious Disease Journal 34, no. 11 (November 2015): 1175–79. https://doi.org/10.1097/INF.0000000000000850.
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  - Berlon, Nicholas R., Robert Qi, Batu K. Sharma-Kuinkel, Hwang-Soo Joo, Lawrence P. Park, Dennis George, Joshua T. Thaden, et al. “Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins..” The Journal of Infection 71, no. 4 (October 2015): 447–57. https://doi.org/10.1016/j.jinf.2015.06.005.
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  - Bergin, Stephen P., Joshua T. Thaden, Jessica E. Ericson, Heather Cross, Julia Messina, Reese H. Clark, Vance G. Fowler, et al. “Neonatal Escherichia coli Bloodstream Infections: Clinical Outcomes and Impact of Initial Antibiotic Therapy..” The Pediatric Infectious Disease Journal 34, no. 9 (September 2015): 933–36. https://doi.org/10.1097/INF.0000000000000769.
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  - Messina, Julia A., Vance G. Fowler, and G Ralph Corey. “Oritavancin for acute bacterial skin and skin structure infections..” Expert Opinion on Pharmacotherapy 16, no. 7 (May 2015): 1091–98. https://doi.org/10.1517/14656566.2015.1026256.
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  - Sharma-Kuinkel, Batu K., Yuling Wu, David E. Tabor, Hoyin Mok, Bret R. Sellman, Amy Jenkins, Li Yu, et al. “Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia..” Journal of Clinical Microbiology 53, no. 1 (January 2015): 227–36. https://doi.org/10.1128/JCM.02023-14.
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  - Tie, Guodong, Jinglian Yan, Julia A. Messina, Robert L. Raffai, and Louis M. Messina. “Inhibition of p38 Mitogen-Activated Protein Kinase Enhances the Apoptosis Induced by Oxidized Low-Density Lipoprotein in Endothelial Progenitor Cells..” Journal of Vascular Research 52, no. 6 (January 2015): 361–71. https://doi.org/10.1159/000443889.
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  - Tie, Guodong, Katharine E. Messina, Jinglian Yan, Julia A. Messina, and Louis M. Messina. “Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells..” Journal of the American Heart Association 3, no. 1 (January 27, 2014). https://doi.org/10.1161/JAHA.113.000241.
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  - Tie, Guodong, Jinglian Yan, Yagai Yang, Brian D. Park, Julia A. Messina, Robert L. Raffai, Philip T. Nowicki, and Louis M. Messina. “Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway..” Journal of Vascular Research 47, no. 6 (January 2010): 519–30. https://doi.org/10.1159/000313879.
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  - Matthay, Katherine K., Gregory Yanik, Julia Messina, Alekist Quach, John Huberty, Su-Chun Cheng, Janet Veatch, et al. “Phase II study on the effect of disease sites, age, and prior therapy on response to iodine-131-metaiodobenzylguanidine therapy in refractory neuroblastoma..” Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 25, no. 9 (March 2007): 1054–60. https://doi.org/10.1200/jco.2006.09.3484.
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  - Messina, Julia A., Su-Chun Cheng, Benjamin L. Franc, Martin Charron, Barry Shulkin, Bao To, John M. Maris, Gregory Yanik, Randall A. Hawkins, and Katherine K. Matthay. “Evaluation of semi-quantitative scoring system for metaiodobenzylguanidine (mIBG) scans in patients with relapsed neuroblastoma..” Pediatric Blood & Cancer 47, no. 7 (December 2006): 865–74. https://doi.org/10.1002/pbc.20777.
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  - DuBois, Steven G., Julia Messina, John M. Maris, John Huberty, David V. Glidden, Janet Veatch, Martin Charron, Randall Hawkins, and Katherine K. Matthay. “Hematologic toxicity of high-dose iodine-131-metaiodobenzylguanidine therapy for advanced neuroblastoma..” Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 22, no. 12 (June 2004): 2452–60. https://doi.org/10.1200/jco.2004.08.058.
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Teaching & Mentoring
Teaching Activities
- Duke's Summer Training in Academic Research (Duke's STAR) Program; Mentor, 2015-2017

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Education, Training, & Certifications

Medical Licensure

Duke Appointment History

In the News

Subject Headings

Global Scholarship

Research

Fellowships, Supported Research, & Other Grants

Selected Publications

Academic Articles

Teaching Activities