Jun Ren | Scholars@Duke

Jun Ren
Visiting Scholar in the Comprehensive Cancer Center

Jun Ren MD, PhD joined Duke University as faculty from 2008. He has actively worked with Professor Kim Lyerly to create the global cancer programs featured on education and research on cancer immunotherapy and cancer vaccinewith Capital University Cancer Center，Beijing, China. They have been keeping pursuing to set up the win-to-win platform thought overcoming these differences and difficulties between US and China since 2008. He and Kim Lyerly secured the transitional research for cancer immunotherapy and achieved clinical research success and expand the global academic prospectives of Duke University.

Current Appointments & Affiliations

Visiting Scholar in the Comprehensive Cancer Center, Duke Cancer Institute, Institutes and Centers 2008

Contact Information

571 Research Drive Room 433, Box 2606, Durham, NC 27710
Box 2606 Med Ctr, Durham, NC 27710
jun.ren@duke.edu (919) 684-6408

Expertise
Global Scholarship
- Research
  - United States of America (Country)
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Song, Q, Ren, J, Yu, J, Wang, X, Zhou, X, and Lyerly, HK. "Abstract 3417: Peripheral CD8+CD28-suppressive T lymphocytes act as a prognosticator among breast cancer patients with adoptive T-cell immunotherapy." July 15, 2016. Full Text
  - Yu, J, Dong, N, Yan, Y, Shao, B, Di, L, Song, G, Che, L, Jia, J, Jiang, H, Liang, X, Zhu, Y, Wang, C, Zahng, J, Zhu, B, Zhou, X, Wang, X, Yang, H, Ren, J, and Lyerly, HK. "Abstract 5298: Two distinctive single nucleotide polymorphisms determine liver metastases responses to docetaxel plus thiotepa for metastatic breast cancer patients." April 15, 2013. Full Text
- Journal Articles
  - Zhou, X, Qiao, G, Wang, X, Song, Q, Morse, MA, Hobeika, A, Gwin, WR, Ren, J, and Lyerly, HK. "CYP1A1 genetic polymorphism is a promising predictor to improve chemotherapy effects in patients with metastatic breast cancer treated with docetaxel plus thiotepa vs. docetaxel plus capecitabine." Cancer chemotherapy and pharmacology 81, no. 2 (February 2018): 365-372. Full Text
  - Song, Q, Ren, J, Zhou, X, Wang, X, Song, G, Hobeika, A, Yuan, Y, and Lyerly, HK. "Circulating CD8+CD28- suppressor T cells tied to poorer prognosis among metastatic breast cancer patients receiving adoptive T-cell therapy: A cohort study." Cytotherapy 20, no. 1 (January 2018): 126-133. Full Text
  - Jiang, N, Qiao, G, Wang, X, Morse, MA, Gwin, WR, Zhou, L, Song, Y, Zhao, Y, Chen, F, Zhou, X, Huang, L, Hobeika, A, Yi, X, Xia, X, Guan, Y, Song, J, Ren, J, and Lyerly, HK. "Dendritic Cell/Cytokine-Induced Killer Cell Immunotherapy Combined with S-1 in Patients with Advanced Pancreatic Cancer: A Prospective Study." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 23, no. 17 (September 2017): 5066-5073. Full Text
  - Zhang, Y, Liu, Y, Ye, Y, Shen, D, Zhang, H, Huang, H, Li, S, Wang, S, and Ren, J. "Quantitative proteome analysis of colorectal cancer-related differential proteins." Journal of cancer research and clinical oncology 143, no. 2 (February 2017): 233-241. Full Text
  - Ren, J, Gwin, WR, Zhou, X, Wang, X, Huang, H, Jiang, N, Zhou, L, Agarwal, P, Hobeika, A, Crosby, E, Hartman, ZC, Morse, MA, H Eng, K, and Lyerly, HK. "Adaptive T cell responses induced by oncolytic Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor therapy expanded by dendritic cell and cytokine-induced killer cell adoptive therapy." Oncoimmunology 6, no. 4 (January 2017): e1264563-null. Full Text
  - Zhou, L, Zhao, L-C, Jiang, N, Wang, X-L, Zhou, X-N, Luo, X-L, and Ren, J. "MicroRNA miR-590-5p inhibits breast cancer cell stemness and metastasis by targeting SOX2." European review for medical and pharmacological sciences 21, no. 1 (January 2017): 87-94.
  - Wang, X, Ren, J, Zhang, J, Yan, Y, Jiang, N, Yu, J, Di, L, Song, G, Che, L, Jia, J, Zhou, X, Yang, H, and Lyerly, HK. "Prospective study of cyclophosphamide, thiotepa, carboplatin combined with adoptive DC-CIK followed by metronomic cyclophosphamide therapy as salvage treatment for triple negative metastatic breast cancers patients (aged <45)." Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 18, no. 1 (January 2016): 82-87. Full Text
  - Song, Q-K, Ren, J, Zhou, X-N, Wang, X-L, Song, G-H, Di, L-J, Yu, J, Hobeika, A, Morse, MA, Yuan, Y-H, Yang, H-B, and Lyerly, HK. "The prognostic value of peripheral CD4+CD25+ T lymphocytes among early stage and triple negative breast cancer patients receiving dendritic cells-cytokine induced killer cells infusion." Oncotarget 6, no. 38 (December 2015): 41350-41359. Full Text
  - Song, Q, Zhou, X, Yu, J, Dong, N, Wang, X, Yang, H, Ren, J, and Lyerly, HK. "The prognostic values of CYP2B6 genetic polymorphisms and metastatic sites for advanced breast cancer patients treated with docetaxel and thiotepa." Scientific reports 5 (November 25, 2015): 16775-. Full Text
  - Zhou, X, Wang, X, Song, Q, Yang, H, Zhu, X, Yu, J, Song, G, Di, L, Ren, J, Shao, H, and Lyerly, HK. "Transformation of alkylating regimen of thiotepa into tepa determines the disease progression through GSTP1 gene polymorphism for metastatic breast cancer patients receiving thiotepa containing salvage chemotherapy." International journal of clinical pharmacology and therapeutics 53, no. 11 (November 2015): 914-922. Full Text
  - Song, Q-K, Wang, X-L, Zhou, X-N, Yang, H-B, Li, Y-C, Wu, J-P, Ren, J, and Lyerly, HK. "Breast Cancer Challenges and Screening in China: Lessons From Current Registry Data and Population Screening Studies." The oncologist 20, no. 7 (July 2015): 773-779. Full Text
  - Lyerly, HK, Fawzy, MR, Aziz, Z, Nair, R, Pramesh, CS, Parmar, V, Parikh, PM, Jamal, R, Irumnaz, A, Ren, J, Stockler, MR, and Abernethy, AP. "Regional variation in identified cancer care needs of early-career oncologists in China, India, and Pakistan." The oncologist 20, no. 5 (May 2015): 532-538. Full Text
  - Song, Q, Zhao, L, Li, J, and Ren, J. "Fruit Consumption Reduces the Risk of Esophageal Cancer in Yanting, People’s Republic of China." Asia Pacific Journal of Public Health 27, no. 4 (May 2015): 469-475. Full Text
  - Lu, M, Zhou, L, Zheng, X, Quan, Y, Wang, X, Zhou, X, and Ren, J. "A novel molecular marker of breast cancer stem cells identified by cell-SELEX method." Cancer Biomarkers 15, no. 2 (January 10, 2015): 163-170. Full Text
  - Huang, HY, Chen, A, Wang, T, Wang, MN, Ning, XK, He, MF, Hu, YZ, Yuan, L, Li, SC, Wang, QW, Liu, H, Chen, ZL, Ren, J, and Sun, Q. "Detecting cell-in-cell structures in human tumor samples by E-cadherin/CD68/CD45 triple staining." Oncotarget 6 (2015): 20278-20287.
  - Zhao, Y-J, Jiang, N, Song, Q-K, Wu, J-P, Song, Y-G, Zhang, H-M, Chen, F, Zhou, L, Wang, X-L, Zhou, X-N, Yang, H-B, Ren, J, and Lyerly, HK. "Continuous DC-CIK infusions restore CD8+ cellular immunity, physical activity and improve clinical efficacy in advanced cancer patients unresponsive to conventional treatments." Asian Pacific journal of cancer prevention : APJCP 16, no. 6 (January 2015): 2419-2423.
  - Song, Q, Christiani, D, XiaorongWang, E, and Ren, J. "The Global Contribution of Outdoor Air Pollution to the Incidence, Prevalence, Mortality and Hospital Admission for Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis." International Journal of Environmental Research and Public Health 11, no. 11 (November 2014): 11822-11832. Full Text
  - Cha, N, Liu, W, Yang, N, Xie, S, Gao, Y, Chen, X, Wang, X, and Ren, J. "Oncogenicity of LHX4 in colorectal cancer through Wnt/β-catenin/TCF4 cascade." Tumor Biology 35, no. 10 (October 2014): 10319-10324. Full Text
  - Jiang, N, Zhu, X, Zhang, H, Wang, X, Zhou, X, Gu, J, Chen, B, and Ren, J. "The relationship between methylenetetrahydrofolate reductase polymorphism and hematological malignancy." Clinical laboratory 60, no. 5 (January 2014): 767-774.
  - Zhu, XS, Yu, HJ, He, BX, Zhou, XN, Jiang, N, Zhang, HM, Wang, XL, and Ren, J. "Mouse Flk-1(+) Sca-1(-) Mesenchymal Stem Cells: Functional Plasticity In Vitro and Immunoregulation In Vivo." Transplantation 97 (2014): 509-517. Full Text
  - Ren, J, Di, L, Song, G, Yu, J, Jia, J, Zhu, Y, Yan, Y, Jiang, H, Liang, X, Che, L, Zhang, J, Wan, F, Wang, X, Zhou, X, and Lyerly, HK. "Selections of appropriate regimen of high-dose chemotherapy combined with adoptive cellular therapy with dendritic and cytokine-induced killer cells improved progression-free and overall survival in patients with metastatic breast cancer: reargument of such contentious therapeutic preferences." Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 15, no. 10 (October 2013): 780-788. Full Text
  - Song, G, Wang, X, Jia, J, Yuan, Y, Wan, F, Zhou, X, Yang, H, Ren, J, Gu, J, and Lyerly, HK. "Elevated level of peripheral CD8(+)CD28(-) T lymphocytes are an independent predictor of progression-free survival in patients with metastatic breast cancer during the course of chemotherapy." Cancer Immunology, Immunotherapy : Cii 62, no. 6 (June 2013): 1123-1130. Full Text
  - Liang, X, Zhang, J, Zhu, Y, Lu, Y, Zhou, X, Wang, Z, Yu, J, Yan, Y, Di, L, Che, L, Jiang, H, Shao, B, Wang, X, Yang, H, Lyerly, HK, and Ren, J. "Specific genetic polymorphisms of IL10-592 AA and IL10-819 TT genotypes lead to the key role for inducing docetaxel-induced liver injury in breast cancer patients." Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 15, no. 4 (April 2013): 331-334. Full Text
  - Xishan, Z, Xinna, Z, baoxin, H, and Jun, R. "Impaired immunomodulatory function of chronic myeloid leukemia cancer stem cells and the possible mechanism involved in it." Cancer Immunology, Immunotherapy 62, no. 4 (April 2013): 689-703. Full Text
  - Quan, Y, Yan, Y, Wang, X, Fu, Q, Wang, W, Wu, J, Yang, G, Ren, J, and Wang, Y. "Impact of cell dissociation on identification of breast cancer stem cells." Cancer Biomarkers 12, no. 3 (March 7, 2013): 125-133. Full Text
  - Zhu, X, He, B, Zhou, X, and Ren, J. "Effects of transplanted bone-marrow-derived mesenchymal stem cells in animal models of acute hepatitis." Cell and Tissue Research 351, no. 3 (March 2013): 477-486. Full Text
  - Sun, H, Jia, J, Wang, X, Ma, B, Di, L, Song, G, and Ren, J. "CD44+/CD24- breast cancer cells isolated from MCF-7 cultures exhibit enhanced angiogenic properties." Clin Transl Oncol 15, no. 1 (January 2013): 46-54. Full Text Link to Item
  - Xishan, Z, Baoxin, H, Xinna, Z, and Jun, R. "Comparison of the effects of human adipose and bone marrow mesenchymal stem cells on T lymphocytes." Cell Biology International 37, no. 1 (January 2013): 11-18. Full Text
  - Che, L, Yuan, Y-H, Jia, J, and Ren, J. "Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients." Chinese Journal of Cancer Research 24, no. 4 (December 2012): 323-331. Full Text
  - Ma, B, Jiang, H, Jia, J, Di, L, Song, G, Yu, J, Zhu, Y, Lu, Z, Wang, X, Zhou, X, and Ren, J. "Murine bone marrow stromal cells pulsed with homologous tumor-derived exosomes inhibit proliferation of liver cancer cells." CLINICAL & TRANSLATIONAL ONCOLOGY 14, no. 10 (October 2012): 764-773. Full Text Link to Item
  - Di, L, Zhu, Y, Jia, J, Yu, J, Song, G, Zhang, J, Che, L, Yang, H, Han, Y, Ma, B, Zhang, C, Yuan, Y, You, M, Wan, F, Wang, X, Zhou, X, and Ren, J. "Clinical safety of induced CTL infusion through recombinant adeno-associated virus-transfected dendritic cell vaccination in Chinese cancer patients." Clinical and Translational Oncology 14, no. 9 (September 2012): 675-681. Full Text
  - Cao, B, Jia, J, Ma, L, Di, L, Song, G, Yuan, Y, Ma, B, Zhu, Y, Yu, J, Wang, X, Zhou, X, Lyerly, HK, and Ren, J. "Recombinant human endostatin could eliminate the pro-angiogenesis priority of SP cells sorted from non-small cell lung cancer cells." Clin Transl Oncol 14, no. 8 (August 2012): 575-585. Full Text Link to Item
  - Song, G, Ren, J, Stojadinovic, A, Chen, W, Sahab, Z, Fu, SW, and Man, Y-G. "Conjunction of tumor cells with lymphocytes: Implications for tumor invasion and metastasis." Cancer Epidemiology 36, no. 4 (August 2012): 354-363. Full Text
  - Wang, Z, Liang, X, Yu, J, Zheng, X, Zhu, Y, Yan, Y, Dong, N, Di, L, Song, G, Zhou, X, Wang, X, Yang, H, Ren, J, and Lyerly, HK. "Non-genetic risk factors and predicting efficacy for docetaxel--drug-induced liver injury among metastatic breast cancer patients." J Gastroenterol Hepatol 27, no. 8 (August 2012): 1348-1352. Full Text Link to Item
  - Dong, N, Yu, J, Wang, C, Zheng, X, Wang, Z, Di, L, Song, G, Zhu, B, Che, L, Jia, J, Jiang, H, Zhou, X, Wang, X, and Ren, J. "Pharmacogenetic assessment of clinical outcome in patients with metastatic breast cancer treated with docetaxel plus capecitabine." Journal of Cancer Research and Clinical Oncology 138, no. 7 (July 2012): 1197-1203. Full Text
  - Lin, X-L, Wang, X-L, Ma, B, Jia, J, Yan, Y, Di, L-J, Yuan, Y-H, Wan, F-L, Lu, Y-L, Liang, X, Shen, T, and Ren, J. "HER2-specific T lymphocytes kill both trastuzumab-resistant and trastuzumab-sensitive breast cell lines in vitro." Chinese Journal of Cancer Research 24, no. 2 (June 2012): 143-150. Full Text
  - Yu, J, Ren, J, Di, L-J, Song, G-H, Zhu, Y-L, Zhang, J, Liang, X, Che, L, Jiang, H-F, Jia, J, and Zhang, C-R. "Mobilization of peripheral blood stem cells using regimen combining docetaxel with granulocyte colony-stimulating factor in breast cancer patients." Chinese Journal of Cancer Research 23, no. 1 (March 2011): 49-53. Full Text
  - Song, G-H, Ren, J, Di, L, Yu, J, Zhang, J, Shao, B, Jia, J, and Sun, W. "Decrease of peripheral blood CD8+/CD28-suppressor T cell followed by dentritic cells immunomodulation among metastatic breast cancer patients." Chinese Journal of Cancer Research 22, no. 4 (December 2010): 310-315. Full Text
  - Zhu, B-D, Li, X-L, Liu, Y, Chang, J, Liu, Y, Zhang, D-D, Wang, Q, Ren, J, and Cui, C-P. "Involvement of Hepatopoietin Cn in the development of human hepatocellular carcinoma." Clinical & Experimental Metastasis 27, no. 8 (December 2010): 571-580. Full Text
  - Cheng, J-P, Yan, Y, Wang, X-Y, Lu, Y-L, Yuan, Y-H, Wang, X-L, Jia, J, and Ren, J. "Circulating tumor cells in metastatic breast cancer: Monitoring response to chemotherapy and predicting progression-free survival." Chinese Journal of Cancer Research 22, no. 3 (September 2010): 201-210. Full Text
  - Song, G-H, Ren, J, Zhang, L-J, Di, L-J, Yuan, Y-H, Yu, J, and Jia, J. "Low correspondence of EGFR mutations in tumor tissue and paired serum of non-small-cell lung cancer patients." Chinese Journal of Cancer Research 22, no. 1 (March 2010): 27-31. Full Text
  - Zhang, L, Ren, J, Pan, K, Ma, J, Li, J, Shen, L, Zhang, X, Li, J, Fan, D, Gail, M, and You, W. "Detection of gastric carcinoma-associated MG7-Ag by serum immuno-PCR assay in a high-risk Chinese population, with implication for screening." International Journal of Cancer 126, no. 2 (January 15, 2010): 469-473. Full Text
  - Ren, J, Jia, J, Zhang, H, Zhang, L, Ma, B, Jiang, H, Di, L, Song, G, and Yu, J. "Dendritic cells pulsed with α-fetoprotein and mutant P53 fused gene induce bi-targeted cytotoxic T lymphocyte response against hepatic carcinoma." Cancer Science 99, no. 7 (July 2008): 1420-1426. Full Text
  - Zhang, X, Yashiro, M, Ohira, M, Ren, J, and Hirakawa, K. "Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma." Cancer science 97, no. 9 (September 2006): 938-944. Full Text
  - Yang, J-Y, Cao, D-Y, Liu, W-C, Zhang, H-M, Teng, Z-H, and Ren, J. "Dendritic cell generated from CD34+ hematopoietic progenitors can be transfected with adenovirus containing gene of HBsAg and induce antigen-specific cytotoxic T cell responses." Cellular Immunology 240, no. 1 (March 2006): 14-21. Full Text
  - Zhang, H-M, Zhang, L-W, Ren, J, Fan, L, Si, X-M, and Liu, W-C. "Induction of α-fetoprotein-specific CD4- and CD8-mediated T-cell response using RNA-transfected dendritic cells." Cellular Immunology 239, no. 2 (February 2006): 144-150. Full Text
  - Zhang, H-M, Zhang, L-W, Liu, W-C, Cheng, J, Si, X-M, and Ren, J. "Comparative analysis of DC fused with tumor cells or transfected with tumor total RNA as potential cancer vaccines against hepatocellular carcinoma." Cytotherapy 8, no. 6 (2006): 580-588. Full Text
  - Zhang, XT, Yashiro, M, Ren, J, and Hirakawa, K. "Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines." Oncology Reports 16 (2006): 563-568.
  - Zhang, L, Zhang, H, Liu, W, Wang, H, Jia, J, Si, X, and Ren, J. "Specific antihepatocellular carcinoma T cells generated by dendritic cells pulsed with hepatocellular carcinoma cell line HepG2 total RNA." Cellular Immunology 238, no. 1 (November 2005): 61-66. Full Text
  - Fan, L, Liu, WC, Zhang, YJ, Ren, J, Pan, BR, Liu, DH, Chen, Y, and Yu, ZC. "Oral Xeloda plus bi-platinu two-way combined chemotherapy in treatment of advanced gastrointestinal malignancies." World Journal of Gastroenterology 11 (2005): 4300-4304.
  - Huang, XF, Wang, CM, Pan, BR, Dai, XW, Fang, L, Yang, JJ, Yu, H, and Ren, J. "Pathological characteristics of gastric leiomyoblastoma." World Journal of Gastroenterology 10 (2004): 3182-3184.
  - Wan, Y, Xu, YY, Jiang, JH, Kong, FS, Xue, FB, Bai, YX, Pan, BR, Ren, J, and Fan, DM. "Chinese literature associated with diagnosis of Helicobacter pylori." World Journal of Gastroenterology 10 (2004): 231-233.
  - Wang, HD, Ren, J, and Zhang, L. "CDH1 germline mutation in hereditary gastric carcinoma." World Journal of Gastroenterology 10 (2004): 3088-3093.
  - Zhang, LW, Ren, J, Zhang, L, Zhang, HM, Jin, B, Pan, BR, Si, XM, Zhang, YJ, Wang, ZH, Pan, YL, and Festein, SM. "Construction and expression of recombined human AFP eukaryotic expression vector." World Journal of Gastroenterology 9 (2003): 1465-1468.
  - REN, J, GE, L, LI, Y, BAI, J, LIU, WC, and SI, XM. "Detection of Circulating CEA Molecules in Human Sera and Leukopheresis of Peripheral Blood Stem Cells with E. coli Expressed Bispecific CEAScFv-Streptavidin Fusion Protein-Based Immuno-PCR Technique." Annals of the New York Academy of Sciences 945, no. 1 (September 2001): 116-118. Full Text
  - Ren, J, Liu, WC, Ge, L, Fan, DM, and Yong, X. "Detection of circulating gastric cancer associated antigen MG7-Ag in human sera with McAb and bispecific ScFv-streptavidin fusion protein-based immuno-PCR technique." Clinical Chemistry 47 (2001): 366-366.
  - Xue, FB, Xu, YY, Wan, Y, Pan, BR, Ren, J, and Fan, DM. "Association of H-pylori infection with gastric carcinoma: a Meta analysis." World Journal of Gastroenterology 7 (2001): 801-804.
  - Ren, J, Chen, Z, Zhou, SJ, Zhang, XY, Pan, BR, and Fan, DM. "Detection of circulating gastric carcinoma-associated antigen MG7-Ag in human sera using an established single determinant immuno-polymerase chain reaction technique." Cancer 88 (2000): 280-285.

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Global Scholarship

Research

Selected Publications

Conference Papers

Journal Articles